Loss of naive T cells may play major role in weakened immune response. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Loss of naive T cells may play major role in weakened immune response. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

J Int Assoc Physicians AIDS Care. 1995 Mar;1(2):32. Unique Identifier : AIDSLINE AIDS/95700335
Prescott LM

Abstract: New evidence suggests that HIV weakens the patient's immune system not by devastating the body's CD4+ cells, but by destroying naive T cells. In people with AIDS, naive T cell and (adult) memory cell ratio become skewed, with about eighty percent of the T cells being memory T cells. Naive T cell loss reduces the patient's ability to respond to new dangers, thus explaining the AIDS patient's susceptibility to opportunistic disease. A longitudinal study is needed to establish the role of naive T cells in HIV-positive persons and the impact of HIV infection on these cells. Dr. Mario Roederer of Stanford University School of Medicine states that treatment options must include treatment that restores the immune system, and that strategies must take into account a patient's naive T-cell count.
Keywords: Acquired Immunodeficiency Syndrome/BLOOD/*IMMUNOLOGY Adult Child CD4-CD8 Ratio Human HIV Infections/BLOOD/*IMMUNOLOGY Immunologic Memory *Lymphocyte Depletion Prospective Studies Retrospective Studies T-Lymphocytes/*CYTOLOGY/IMMUNOLOGY NEWSLETTER ARTICLE

KWDacquiredimmunodeficiencysyndrome/blood/KWDimmunologyadultchildcd4-cd8ratiohumanhivinfections/blood/KWDimmunologyimmunologicmemoryKWDlymphocytedepletionprospectivestudiesretrospectivestudiest-lymphocytes/KWDcytology/immunologynewsletterarticle
951130
M95B0920

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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