Topotecan now available for HIV, PML research. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Topotecan now available for HIV, PML research. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

AIDS Treat News. 1995 Apr 7;(no 220):4. Unique Identifier : AIDSLINE AIDS/95700342

Abstract: Topotecan has shown a strong anti-HIV effect, however, SmithKline Beecham is not interested in developing it for AIDS because of its toxicity. Research is now being conducted to learn whether the toxicity and anti-HIV effect can be separated. Prospective researchers must file pre-clinical or clinical plans for SmithKline Beecham approval and must sign an agreement that they will not file for a use patent on the drug. Researchers can obtain more information by calling Sharyn Arnold at (215)751-7074 or fax at (215)751-7655.
Keywords: Antineoplastic Agents/ADVERSE EFFECTS/*THERAPEUTIC USE Camptothecin/ANALOGS & DERIVATIVES/ADVERSE EFFECTS/*THERAPEUTIC USE Human HIV Infections/COMPLICATIONS/*DRUG THERAPY Leukoencephalopathy, Progressive Multifocal/COMPLICATIONS/*DRUG THERAPY NEWSLETTER ARTICLE

KWDantineoplasticagents/adverseeffects/KWDtherapeuticusecamptothecin/analogs&derivatives/adverseeffects/KWDtherapeuticusehumanhivinfections/complications/KWDdrugtherapyleukoencephalopathy,progressivemultifocal/complications/KWDdrugtherapynewsletterarticle
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