AZT + 3TC: early results promising. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

AZT + 3TC: early results promising. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Common Factor. 1995 Apr;(no 10):16. Unique Identifier : AIDSLINE AIDS/95700369
Colvin R; Haas G

Abstract: The results of recent trials testing the combination of AZT and 3TC were reported at the AIDS Conferences in Glasgow, Scotland in November, and Washington, DC in February. Two sets of nearly parallel studies were conducted in Europe and the U.S.; each had one study of AZT-naive persons and one of AZT-experienced persons. The trials monitored changes in blood markers (CD4 counts and viral load) but not clinical progression. The combination of AZT and 3TC had a greater effect than either drug alone or any other combination previously tested, but, it is not known if these effects will result in improved clinical outcomes. Clinical trials are beginning now to determine if AZT and 3TC can delay symptoms and death.

Keywords: Clinical Trials CD4 Lymphocyte Count Drug Therapy, Combination Human Zalcitabine/ANALOGS & DERIVATIVES/ADMINISTRATION & DOSAGE/ *THERAPEUTIC USE Zidovudine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE NEWSLETTER ARTICLE

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M95B0897

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