Pediatrics clinical trial drops AZT-alone arm. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Pediatrics clinical trial drops AZT-alone arm. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Common Factor. 1995 Apr;(no 10):17. Unique Identifier : AIDSLINE AIDS/95700370
Haas GJ

Abstract: A clinical trial (ACTG 152), involving 839 symptomatic children, aged 3 months to 18 years, was modified to discontinue the AZT monotherapy arm after a review board found that children on the AZT-only arm had significantly worse symptom-free survival time. The Data and Safety Monitoring Board (DSMB) advised similarly-designed trials to eliminate any AZT-alone arm. Until the complete data is released, the effect of the broad range of ages on the results will remain unclear. Developing an individual treatment plan for each person is important because different children will react in different ways in terms of treatment benefits and toxicities. The complete results of ACTG 152, and their implications, will be forthcoming towards year's end.
Keywords: Adolescence Child Child, Preschool Didanosine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE Drug Therapy, Combination Human Infant Treatment Failure Zidovudine/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE NEWSLETTER ARTICLE RANDOMIZED CONTROLLED TRIAL CLINICAL TRIAL

KWDadolescencechildchild,preschooldidanosine/administration&dosage/KWDtherapeuticusedrugtherapy,combinationhumaninfanttreatmentfailurezidovudine/administration&dosage/KWDtherapeuticusenewsletterarticlerandomizedcontrolledtrialclinicaltrial
951130
M95B0896

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