Neuro-cognitive disorders on the rise. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Neuro-cognitive disorders on the rise. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

GMHC Treat Issues. 1995 Mar;9(3):7-8. Unique Identifier : AIDSLINE AIDS/95700412
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Abstract: It has been determined that five AIDS-related brain and nervous system diseases (toxoplasmosis, cryptococcal meningitis, progressive multifocal leukoencephalopathy, central nervous system lymphoma, and sensory neuropathies) are becoming growing problems for people with AIDS. These diseases, while being the initial AIDS-defining condition in only 5 to 10 percent of the cases, were a secondary complication in 40 to 60 percent of the cases. The Multicenter AIDS Cohort Study found antiretroviral treatment did not reduce the incidence of HIV dementia, standing in contrast with other reports that have found the incidence of dementia falling in those treated with AZT, in particular. Results from a large post-mortem study presented at the American Academy of Neurology Annual Meeting in 1994 show that AZT treatment greatly reduces the risk of productive HIV infection of the brain and that early discontinuation of AZT leaves patients vulnerable to HIV encephalitis. The cause of HIV dementia remains unknown, but may occur through complex indirect pathways, which could involve cytokine and immunological deterioration.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS/DRUG THERAPY AIDS Dementia Complex/EPIDEMIOLOGY/ETIOLOGY Central Nervous System Neoplasms/COMPLICATIONS/EPIDEMIOLOGY Cohort Studies CD4 Lymphocyte Count Human Incidence Leukoencephalopathy, Progressive Multifocal/COMPLICATIONS/ EPIDEMIOLOGY Lymphoma/COMPLICATIONS/EPIDEMIOLOGY Meningitis, Cryptococcal/COMPLICATIONS/EPIDEMIOLOGY Nervous System Diseases/*COMPLICATIONS/EPIDEMIOLOGY Toxoplasmosis/COMPLICATIONS/EPIDEMIOLOGY Zidovudine/THERAPEUTIC USE NEWSLETTER ARTICLE

KWDacquiredimmunodeficiencysyndrome/
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M95B0881

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