Second National Retrovirus conference: a further report. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Second National Retrovirus conference: a further report. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

GMHC Treat Issues. 1994 Mar;9(3):4-5, 7. Unique Identifier : AIDSLINE AIDS/95700410
Torres G

Abstract: It was reported at the 1995 Second National Retrovirus Conference that AIDS has now surpassed unintentional injury as the leading cause of death for male Americans between the ages of 25 to 44, and for women, AIDS is fourth behind unintentional injury. A study of multidrug resistant tuberculosis that showed improved survival rates as long as appropriate therapy began within four weeks of diagnosis was also presented. The current recommendation is to consider the PPD skin test positive in persons with HIV if the bump that appears is over five millimeters in diameter. A new ganciclovir implant study demonstrated the implant's effectiveness in preventing CMV disease progression with low rates of complications, suggesting implants should probably replace intravenous ganciclovir as maintenance therapy. Another study demonstrated the effectiveness of cidofovir as a treatment for CMV infection, indicating that cidofovir was appropriate as a salvage therapy for those failing ganciclovir and foscarnet. In vitro studies involving Taxol and Kaposi's sarcoma (KS) show partial responses (55 percent), and some disease stabilization (40 percent). Four of five patients with pulmonary KS responded with clearance of tumor lesions. The first randomized trial involving Loviride with zidovudine has shown a sustained increase in CD4 cells with headache, nausea, and diarrhea as the most common side effects. Preliminary assessments reveal a reduction in viral load using the combination as opposed to monotherapy. Additional Loviride combination trials are being planned in Europe.

Keywords: Acetamides/THERAPEUTIC USE Acetophenones/THERAPEUTIC USE *Acquired Immunodeficiency Syndrome Adult Antiviral Agents/THERAPEUTIC USE Cause of Death Cytomegalovirus Retinitis/COMPLICATIONS/DRUG THERAPY Cytosine/ANALOGS & DERIVATIVES/THERAPEUTIC USE Female Ganciclovir/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Human Male Organophosphorus Compounds/THERAPEUTIC USE Paclitaxel/THERAPEUTIC USE RNA-Directed DNA Polymerase/ANTAGONISTS & INHIB Sarcoma, Kaposi's/DRUG THERAPY/ETIOLOGY Tuberculosis/COMPLICATIONS NEWSLETTER ARTICLE

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