[Human papillomavirus dermatopathology: in situ hybridization of types 6/11, 16/18 and 31/33/51] NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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[Human papillomavirus dermatopathology: in situ hybridization of types 6/11, 16/18 and 31/33/51]

Diss Abstr Int [C]; 55(2):528 1994. Unique Identifier : AIDSLINE ICDB/95607096
Andreu Navarro FJ; Universitat Autonoma de Barcelona, Spain

Abstract: We performed an in situ hybridization study with biotinylated DNA probes to assess the participation of HPV 6/11, 16/18 and 31/33/51 in various skin disorders. Specific objectives: (1) Evaluation of the different clinical patterns of condyloma acuminatum in AIDS and non-AIDS patients in relation to HPV infection. (2) Evaluation of the possible participation of HPV in extragenital Bowen disease. (3) Determination of the possible participation of HPV in bowenoid papulosis and prevalence of the HPV type involved. (4) Determination of the possible participation of HPV in squamous cell carcinoma of the penis and vulva and comparison with nongenital skin squamous cell carcinoma. (5) Determination of the possible participation of HPV in hairy leukoplakia. Results: (1) Positive HPV 6/11 in situ hybridization in 100% of cases of condyloma acuminatum in AIDS patients (presence of focal positivity for HPV 16/18 in 10% and for HPV 31/33/51 in 50%). (2) Positive HPV 6/11 in situ hybridization in 90% of condyloma acuminatum cases in non-immunosuppressed patients (absence of HPV 16/18 and 31/33/51 positivity in all cases). (3) Weaker positivity limited to the stratum corneum with immunohistochemistry in those cases studied as controls. (4) Positive in situ hybridization in 50% of cases of bowenoid papulosis (HPV 16/18 in all but one), with negative immunohistochemical results in 100% of cases. (5) Negative in situ hybridization and immunohistochemical results in all cases of extragenital Bowen's disease, genital and extragenital squamous cell carcinoma and hairy leukoplakia. Conclusions: (1) There is a pathogenic relationship of HPV with condyloma acuminatum, with no difference of the types involved in AIDS and non-AIDS patients. (2) There is no pathogenic relationship between HPV and extragenital Bowen's disease. (3) There is a relationship between bowenoid papulosis and HPV (essentially with type 16/18) and a low viral proliferative rate in these lesions, in agreement with the negative immunohistochemical results, (4) There is no pathogenic relationship between HPV and extragenital squamous cell carcinomas. (5) There is no relationship between HPV and massively infiltrating squamous cell carcinoma of the genital area (penis and vulva). (6) There is no pathogenic relationship between HPV and hairy leukoplakia. (7) In situ hybridization is a useful tool for the study and typification of HPV infections. (Abstract shortened by UMI.) (Full text NOT AVAILABLE FROM UNIVERSITY MICROFILMS INT'L.)
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS Bowen's Disease/*VIROLOGY Carcinoma, Squamous Cell/*VIROLOGY Condylomata Acuminata/COMPLICATIONS/*VIROLOGY Human Immunohistochemistry In Situ Hybridization Papillomavirus, Human/*GENETICS/PATHOGENICITY Penile Neoplasms/*VIROLOGY Tumor Virus Infections/COMPLICATIONS/VIROLOGY Vulvar Neoplasms/*VIROLOGY THESISKWDacquiredimmunodeficiencysyndrome/complicationsbowen'sdisease/KWDvirologycarcinoma,squamouscell/KWDvirologycondylomataacuminata/complications/KWDvirologyhumanimmunohistochemistryinsituhybridizationpapillomavirus,human/KWDgenetics/pathogenicitypenileneoplasms/KWDvirologytumorvirusinfections/complications/virologyvulvarneoplasms/KWDvirologythesis
950530
M9551042

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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