Virus sidesteps convergent therapy. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Virus sidesteps convergent therapy. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Treat Issues. 1995 Jan;9(1):6. Unique Identifier : AIDSLINE AIDS/95700110

Abstract: The ambiguous results from ACTG 241, a federally funded clinical trial, may mark the end for the convergent combination therapy. The study enrolled volunteers with CD4 counts between 50 and 350 who had received at least six months of nucleoside analog therapy. They were randomized to take either a combination of AZT, ddi and nevirapine or AZT/ddI therapy. Although convergent combination therapy initially made a difference, the final difference in HIV load was not statistically significant. A small difference in absolute CD4 counts (30 cells or so) did not affect the incidence of new symptoms or death. Those on convergent therapy fared worse in terms of disease progression and clinical endpoints.

Keywords: Antiviral Agents/THERAPEUTIC USE CD4 Lymphocyte Count/DRUG EFFECTS Didanosine/THERAPEUTIC USE Drug Therapy, Combination Human HIV Infections/BLOOD/*DRUG THERAPY Pyridines/THERAPEUTIC USE Zidovudine/THERAPEUTIC USE NEWSLETTER ARTICLE CLINICAL TRIAL
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