Absence of HTLV-I DNA sequences in cutaneous T-cell lymphoma/mycosis fungoides. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Absence of HTLV-I DNA sequences in cutaneous T-cell lymphoma/mycosis fungoides.

Acta Morphol Hung. 1992;40(1-4):249-55. Unique Identifier : AIDSLINE MED/95149755
Lapis P; Freeman J; Bitter MA; Golitz LE; Department of Pathology and Dermatology, University of Colorado; Health Sciences Center, Denver.

Abstract: Recently, the presence of deleted forms of the HTLV-I provirus was described in 6 out of 6 cases of CTCL. We investigated whether the presence of these viral genomes could be verified in 20 patients with CTCL using the polymerase chain reaction (PCR) and Southern blot analysis. Only one of the 20 cases showed a band corresponding to the pX region of HTLV-I. These data indicate that in the majority of CTCL cases, sequences closely related to HTLV-I are not present, or their copy number is below the limit of detection employed in this study.
Keywords: Base Sequence Blotting, Southern DNA, Viral/*ANALYSIS/GENETICS Human HTLV-I/GENETICS/*ISOLATION & PURIF Lymphoma, T-Cell, Cutaneous/*VIROLOGY Molecular Sequence Data Mycosis Fungoides/*VIROLOGY Polymerase Chain Reaction Support, Non-U.S. Gov't JOURNAL ARTICLEKWDbasesequenceblotting,southerndna,viral/KWDanalysis/geneticshumanhtlv-i/genetics/KWDisolation&puriflymphoma,t-cell,cutaneous/KWDvirologymolecularsequencedatamycosisfungoides/KWDvirologypolymerasechainreactionsupport,non-uKWDsKWDgov'tjournalarticle
950530
M9551013

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