1995

The:immunization of infants and children. Version 3.0. [computer file].: Orlando, FL : Computerized Educational Systems, c1994 1 computer disk : col. ; 3 1/2 in. + 1 guide (1 v., various foliations) Unique Identifier : AIDSLINE AV/9501002; Lerner H; (Producer) Based on recently released recommendations of the American Academy of Pediatrics, this program contains an updated immunization schedule and content on the new combined vaccines. Discussion of how to handle the immunization of children who are HIV positive can also be found in this update.
Newsletter. No. 1 (May 1989)-: Nairobi, Kenya : NARESA, [1989- v. : ill Unique Identifier : AIDSLINE CAT/9438020
[Objectif SIDA : l'homeopathie a l'assaut du mal du siecle.]: Bruxelles : Didier Hatier, c1989 173 p (Collection Grands documents) Unique Identifier : AIDSLINE CAT/9407157; Jenaer M
AIDS : more convincingly a stress-induced physiological disorder than a purely viral disease.: Falls Church, VA : Foundation for the Simple in Medicine, [1989] 19 p. : ill (Journal, science in medicine simplified ; special issue) Unique Identifier : AIDSLINE CAT/9423744
Adolescents and AIDS : stopping the time bomb.: Denver, Colo. : National Conference of State Legislatures, [1990] 11 p. : ill (State legislative report ; vol. 15, no. 12) Unique Identifier : AIDSLINE CAT/9409445; Yondorf B
Protecting health care workers from HIV infection.: Denver, Colo. : National Conference of State Legislatures, [1990] 9 p (State legislative report ; vol. 15, no. 11) Unique Identifier : AIDSLINE CAT/9409444; Wright B
Women, AIDS, and public health policies : a National Women's Health Network report.: Washington, D.C. : The Network, 1990 1 v. (unpaged) Unique Identifier : AIDSLINE CAT/9409443
Co-operation agreement between the European Economic Community and the Republic of Finland in the field of medical and health research, Brussels, 21 May 1990 : presented to Parliament by the Secretary of State for Foreign and Commonwealth Affairs by Command of Her Majesty.: London : H.M.S.O., [1990] 7 p (European Communities ; no. 79) Unique Identifier : AIDSLINE CAT/9404858
Diagnosis and management of parasitic diseases in AIDS.: [Geneva] : World Health Organization, [1990] 18 p Unique Identifier : AIDSLINE CAT/9504933; Mott KE
[L':impact du SIDA sur la situation economique, sociale, et psychologique de la famille et de l'enfant au Rwanda : etude.]: Ruhengeri : Republique rwandaise, Ministere de la sante, [1991] vii, 107 p. : ill Unique Identifier : AIDSLINE CAT/9436040; Kabeja T
AIDS, a Christian response.: Balaka, Malawi : Printed by Montfort Missionaries, [1991] 80 p. : ill Unique Identifier : AIDSLINE CAT/9436889; Cullen T
[Compte rendu du Forum Les Femmes et le SIDA, les enjeux.]: Quebec : Gouvernement du Quebec, Ministere de la sante et des services sociaux, Centre quebecois de coordination sur le sida, [1991] xiv, 107 p Unique Identifier : AIDSLINE CAT/9406564
Directory of current HIV/AIDS research in Canada, 1988-1991.: Montreal : Centre for AIDS Studies, Dept. of Community Health, Montreal General Hospital, c1991 ix, 189, 191 p. : port Unique Identifier : AIDSLINE CAT/9404632; Hankins C; Daley M
[La:face cachee du SIDA : synthese.]: Bergerac : Thierry Bernardin, [1992 or 1993] 57 p. : ill Unique Identifier : AIDSLINE CAT/9418181; Bernardin T
The:Sanford guide to HIV/AIDS therapy.: Dallas, Texas : Antimicrobial Therapy, Inc., v Unique Identifier : AIDSLINE CAT/9439733; Sanford JP
The:acquired immune deficiency syndrome (AIDS) : 20 June 1983-28 December 1987.: [Gaborone] : University of Botswana, [1992] 139 p (Press cuttings ; no. 6) Unique Identifier : AIDSLINE CAT/9500407; Kwafo-Akoto KO; Monageng SB; Morupisi L; (Botswana)
[Entwicklung und Prufung von Adjuvantien fur HIV Impfstoffe.]: [Frankfurt am Main] : VAS, c1992 190 p. : ill Unique Identifier : AIDSLINE CAT/9441892; Stieneker F
[La:Infeccio pel virus de la immunodeficiencia humana (VIH) en el medi sanitari.] 1a ed.: Barcelona : Generalitat de Catalunya, Dept. de Sanitat i Seguretat Social, 1992 80 p Unique Identifier : AIDSLINE CAT/9409130
[Strategie quebecoise de lutte contre le sida et de prevention des maladies transmissibles sexuellement. Phase 3, plan d'action 1992-1995.]: [Quebec] : Gouvernement du Quebec, Ministere de la sante et des services sociaux, Centre quebecois de coordination sur le sida, [1992?] 31 p Unique Identifier : AIDSLINE CAT/9433893
[SIV-Zeitung : offizielles Verbandsorgan des Schweizerischen Invalidenverbandes.]: Olten : Schweizerischer Invalidenverband, v. : ill., ports Unique Identifier : AIDSLINE CAT/9424720
AIDS and your response : proceedings, 11-14 November 1992, Eskon [i.e. Eskom] Conference & Exhibition Centre, Midrand, South Africa.: Ansty, Coventry, U.K. : Institute of World Concerns, c1992 vi, 226 p. : ill Unique Identifier : AIDSLINE CAT/9442307
[Der:Einfluss von Ersatzdrogenprogrammen auf die Drogensucht unter besonderer Berucksichtigung von Beschaffungskriminalitat, Beschaffungsprostitution, und HIV-Infektionsrate von i.v. Drogenabhangigen.]: Frankfurt am Main ; New York : Peter Lang, c1993 213 p (Europaische Hochschulschriften. Reihe 2, Rechtswissenschaft, ISSN 0531-7312 ; Bd. 1442) Unique Identifier : AIDSLINE CAT/9437184; Weymann S
[Informe de la Cirujana General al pueblo de los Estados Unidos sobre la infeccion por el VIH y el SIDA.]: General [Washington, D.C.] : U.S. Public Health Service, [1993?] 27 p. : ill., port Unique Identifier : AIDSLINE CAT/9443071
NARESA monograph. No. 1-: Nairobi, Kenya : NARESA, 1993- v Unique Identifier : AIDSLINE CAT/9501763
AIDS/STD barriers, benefits and risks : leakage of condoms and medical gloves : causes, incidence, and prevention : OSHA's standard for protection of workers against bloodborne pathogens.: Owings Mills, Md. : Noble House, c1993 iv, 96 p. : ill Unique Identifier : AIDSLINE CAT/9441249; Riordan JJ
HIV and AIDS in India : an update for action.: Bangalore : Indian Society of Health Administrators (ISHA), c1993 71 p Unique Identifier : AIDSLINE CAT/9503808; Sahni A
HIV/AIDS group counselling theory and practice.: Nairobi : NARESA, [1993] ii, 62 p. : ill (NARESA monograph ; no. 1) Unique Identifier : AIDSLINE CAT/9439452; Balmer DH
Safety in numbers : safer sex and gay men.: London : Cassell, 1993 xiv, 288 p Unique Identifier : AIDSLINE CAT/9502406; King E
The:cure for HIV and AIDS.: San Diego, CA : ProMotion Pub., [c1993] xiv, 433 p. : ill Unique Identifier : AIDSLINE CAT/9504628; Clark HR
Report of a meeting on HIV infection in leprosy : Geneva, 1-2 May 1993.: [Geneva] : Word Health Organization, c1993 15 p Unique Identifier : AIDSLINE CAT/9504937
AIDS : foundations for the future.: London ; Bristol, PA : Taylor & Francis, 1994 vii, 217 p. : ill (Social aspects of AIDS) Unique Identifier : AIDSLINE CAT/9443315; Aggleton P; Davies P; Hart G
Directory of HIV clinical trials in Canada.: Vancouver, B.C. : Canadian HIV Trials Network, 1994 53 p Unique Identifier : AIDSLINE CAT/9502235
[Etica y SIDA : trabajos premiados en las Jornadas de Etica Medica, setiembre 1993.]: [Buenos Aires?] : Sociedad de Etica en Medicina (AMA), [1994] x, 87 p Unique Identifier : AIDSLINE CAT/9443351
My own country : a doctor's story of a town and its people in the age of AIDS.: New York : Simon & Schuster, c1994 347 p Unique Identifier : AIDSLINE CAT/9437890; Verghese A
[El:VIH en los adultos.]: Rockville, MD : U.S. Dept. of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, [1994] 17 p. : ill (Guia de practica clinica ; no. 7. Guia de informacion) Unique Identifier : AIDSLINE CAT/9436048
The:cure of AIDS.: Rio de Janeiro : Relume Dumara, c1994 47, 47 p Unique Identifier : AIDSLINE CAT/9441068; Souza Hd
Essays on AIDS : an introduction to the influence of a virus on politics.: Miami : J.H. Boykin, c1994 iv, 73 p Unique Identifier : AIDSLINE CAT/9501726; Boykin JH
Global AIDS policy.: Westport, Conn. : Bergin & Garvey, 1994 x, 250 p. : ill Unique Identifier : AIDSLINE CAT/9501700; Feldman DA
The:HIV/AIDS and tuberculosis epidemics : implications for TB control.: [Geneva] : World Health Organization, [1994] 13 p. : ill Unique Identifier : AIDSLINE CAT/9500079
HIV/AIDS work group on health care access issues for Hispanic Americans.: Americans [Rockville, Md.] : U.S. Dept. of Health & Human Service, Public Health Service, Health Resources and Services Administration, Bureau of Health Services [i.e. Resources] Development, [1994] 32 p (DHHS publication ; no. HRSA RD-SP-93-8) Unique Identifier : AIDSLINE CAT/9441265
HIV infection in pregnancy. 1st ed.: Cheshire : Books for Midwives Press, 1994 77 p. : ill (Midwifery practice guides ; 1) Unique Identifier : AIDSLINE CAT/9443344; Shepherd CM
Knowledge, attitudes, beliefs, and behaviors (KABB) surveys : valuable tools in HIV prevention.: Washington, DC : United States Conference of Mayors, c1994 11 p (Technical assistance reports ; vol. 11, no.5 (Dec. 1994)) Unique Identifier : AIDSLINE CAT/9502834
The:second plague of Europe : AIDS prevention and sexual transmission among men in Western Europe.: New York : Haworth Press, c1994 xiv, 123 p. : ill (Haworth gay and lesbian studies) Unique Identifier : AIDSLINE CAT/9500446; Pollak M
Aids and pregnancy : reactions to problems of HIV-positive pregnant women and their children in Chiang Mai (Thailand).: Amsterdam : VU University Press, 1994 118 p Unique Identifier : AIDSLINE CAT/9500293; Batterink C
AIDS and the new orphans : coping with death.: Westport, Conn. : Auburn House, 1994 viii, 158 p Unique Identifier : AIDSLINE CAT/9500068; Dane BO; Levine C
[Des virus et des hommes.]: Paris : O. Jacob, c1994 315 p (Sciences) Unique Identifier : AIDSLINE CAT/9443233; Montagnier L
Determining the unit cost of services : a guide for estimating the cost of services funded by the Ryan White Care Act of 1990.: [Rockville, Md.?] : U.S. Dept. of Health & Human Services, Public Health Service, Health Resources and Services Administration ; Washington, DC : For sale by the U.S. G.P.O., Supt. of Docs., [1994?] 36 p. : ill Unique Identifier : AIDSLINE CAT/9441267
Last served? : gendering the HIV pandemic.: London ; Bristol, PA : Taylor & Francis, 1994 vi, 163 p (Social aspects of AIDS) Unique Identifier : AIDSLINE CAT/9443322; Patton C
Medical management of HIV infection.: Glenview, Ill. : Physicians & Scientists Pub. Co., c1994 vii, 250 p Unique Identifier : AIDSLINE CAT/9500756; Bartlett JG
AIDS : setting a feminist agenda.: London ; Bristol, PA : Taylor & Francis, 1994 ix, 208 p (Feminist perspectives on the past and present) Unique Identifier : AIDSLINE CAT/9443317; Doyal L; Naidoo J; Wilton T
AIDS--today, tomorrow : an introduction to the HIV epidemic in America. 2nd ed.: Atlantic Highlands, N.J. : Humanities Press, 1994 xii, 263 p. : ill Unique Identifier : AIDSLINE CAT/9442624; Walker RS
Last songs : AIDS and the music therapist. 2nd ed.: Toronto : Music Therapy Services of Metropolitan Toronto, c1994 ix, 38 p Unique Identifier : AIDSLINE CAT/9440091; Rykov M
Report : meeting of national AIDS programme managers.: Pacific Manila, Philippines : Printed and distributed by World Health Organization, Regional Office for the Western Pacific, [1994] 24 p (Report series ; no. RS/94/GE/05(GUM)) Unique Identifier : AIDSLINE CAT/9441028
The:Johns Hopkins Hospital guide to medical care of patients with HIV infection. 5th ed.: Baltimore : Williams & Wilkins, c1995 x, 143 p. : ill Unique Identifier : AIDSLINE CAT/9504384; Bartlett JG
HIV/AIDS primary care handbook. [1995]-: Norwalk, Conn. : Appleton & Lange, c1995- v Unique Identifier : AIDSLINE CAT/9501434
Ryan White CARE Act : access to services by minorities, women, and substance abusers : report to the Chairman, Committee on Labor and Human Resources, and the Honorable Hank Brown, U.S. Senate.: Washington, D.C. : The Office, [1995] 25 p. : ill Unique Identifier : AIDSLINE CAT/9504947
The:DNA provirus : Howard Temin's scientific legacy.: Washington, D.C. : ASM Press, c1995 xxxii, 324 p. : ill, ports Unique Identifier : AIDSLINE CAT/9505412; Temin HM; Cooper GM; Temin RG; Sugden B
The role of radiation therapy in acquired immunodeficiency syndrome (AIDS) (Meeting abstract).: International Congress of Radiation Oncology 1993. June 21-25, 1993, Kyoto, Japan, p. 405, 1993.. Unique Identifier : AIDSLINE ICDB/95606181; Cordon P; Porkola J; Frank E; Dept. of Rad. Oncology, Century City Hosp., Los Angeles, CA; The Department of Radiation Oncology at Century City Hospital, an AIDS referral center, has retrospectively analyzed the radiation treatment results of over 200 patients with AIDS. Radiation therapy was used in the management of Kaposi s sarcoma and AIDS-related lymphomas. Kaposi s sarcoma skin lesions are often cosme
Seventeenth Annual Cancer Symposium, October 25-27, 1993, San Diego, CA.: Seventeenth Annual Cancer Symposium, October 25-27, 1993, San Diego, CA, Scripps Memorial Hospitals, La Jolla, CA 242 p., 1993.. Unique Identifier : AIDSLINE ICDB/95606687; Anonymous; No affiliation; This book is comprised of five sections covering some of the major areas of clinical oncologic research and the major issues involved. The first section on breast cancer brings together contributions on breast cancer in young women and controversies in primary radiation therapy (Barbara Fowble), issues in systemic the
Human T cells transformed in vitro by human T-cell leukemia virus (Meeting abstract).: 2nd International Conference on Gene Regulation/Oncogenesis/AIDS, September 23-30, 1993, Loutraki, Greece, p. 34, 1993.. Unique Identifier : AIDSLINE ICDB/95606697; Taresis S; Parks W; Parks E; Persaud D; Munoz J; New York University School of Medicine, New York, NY; To study early events associated with HTLV-1/2 infection and transformation it is necessary to isolate clonal populations of HTLV-exposed lymphocytes early after infection. Peripheral blood mononuclear cells (PBMNCs) were prestimulated prior to coculture with irradiated HTLV-1 positive C91/PL cells. PBMNCs (10(4)/well
[Human papillomavirus dermatopathology: in situ hybridization of types 6/11, 16/18 and 31/33/51]: Diss Abstr Int [C]; 55(2):528 1994. Unique Identifier : AIDSLINE ICDB/95607096; Andreu Navarro FJ; Universitat Autonoma de Barcelona, Spain; We performed an in situ hybridization study with biotinylated DNA probes to assess the participation of HPV 6/11, 16/18 and 31/33/51 in various skin disorders. Specific objectives: (1) Evaluation of the different clinical patterns of condyloma acuminatum in AIDS and non-AIDS patients in relation to HPV infection. (2)
The fluorine atom as a probe for drug monitoring. Chemical synthesis of fluorinated drugs and in vivo studies in animal tumor models.: Diss Abstr Int [B]; 54(12):6150 1994. Unique Identifier : AIDSLINE ICDB/95607170; Parti SC; Univ. of Southern California; Nuclear medicine imaging technology and nuclear magnetic resonance spectroscopy are two unique methodologies that can be utilized for the detection and analysis of compounds containing the fluorine atom. While the magnetic resonance technology using the naturally occurring fluorine (19F) allows the identification of t
Human T-lymphotropic virus type I-mediated lymphocyte immortalization: viral replication and lymphoproliferation.: Diss Abstr Int [B]; 55(2):289 1994. Unique Identifier : AIDSLINE ICDB/95607438; Kimata JT; Washington Univ.; Infection of T-cells by human T-lymphotropic virus type I (HTLV-I) is associated with aberrant immune activation. The activation state may play a central role in the development of adult T-cell leukemia/lymphoma and tropical spastic paraparesis/HTLV-I associated myelopathy. Therefore, understanding how HTLV-I deregula
Structure and biological activity of isolates from Anogeissus acuminata.: Diss Abstr Int [B]; 54(12):6218 1994. Unique Identifier : AIDSLINE ICDB/95607141; Rimando AM; Univ. of Illinois at Chicago, Health Sciences Center; Phytochemical work on Anogeissus acuminata [(Roxb ex DC) Guill and Perr var lanceolata Wall ex CB Clarke] (Combretaceae) led to the isolation of three new and four known compounds. The new compounds were identified as 2-(2 ,4 -dihydroxybenzyl)-3-(3 ,4 methylenedioxybenzyl)-1,3-butadiene, which was given the common na
Enumeration of T-cells subsets in patients with HIV infection. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Clin Care. 1995 Jan;7(1):1-3. Unique Identifier : AIDSLINE AIDS/95700010; Rabson A; Quantitation of CD4+ lymphocytes is important in the staging and monitoring of patients infected with HIV. Throughout the course of the disease, the total T cell levels remain fairly constant despite a fall in CD4+ cell count, due to a concomitant rise in CD8+ cells. Therefore, the ratio of CD4+ to CD8+ cells is an ad
FDA approves d4T as alternative to AZT, ddI, or ddC. Food and Drug Administration. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Clin Care. 1995 Jan;7(1):4, 10. Unique Identifier : AIDSLINE AIDS/95700011; Friedland G; Stavudine , 2 ,3 -didehydro-3 deoxy thymidine ( d4T ) has been approved by the Food and Drug Administration and is the fourth commercially available drug in the nucleoside analog reverse
Information for patients about intravenous lines. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Clin Care. 1995 Jan;7(1):5-6. Unique Identifier : AIDSLINE AIDS/95700012; Some medications must be administered intravenously because they can be given in more effective doses, and/or without side effects. Temporary intravenous (IV) lines are tubes inserted into the arm through a needle, where they can remain from a few days to several weeks. Permanent IV lines, either port- or Hickman-type
What the new Congress has in store for AIDS funding. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Physicians Assoc AIDS Care. 1995 Jan;2(1):6-8. Unique Identifier : AIDSLINE AIDS/95700081; Cimons M; Clinicians, activists, and people with AIDS are nervous about what Republican lawmakers may do to medical and social programs, particularly the Ryan White Care Act, HIV prevention and education programs of the Centers for Disease Control and Prevention, and Medicaid. They worry that funding for these programs may be e
PAAC presses for nutrition reimbursement for Federal employees. Physicians Association for AIDS Care. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Physicians Assoc AIDS Care. 1995 Jan;2(1):9. Unique Identifier : AIDSLINE AIDS/95700082; Gordon Nary, executive director of the Physicians Association for AIDS Care (PAAC), joined representatives from the American Dietetic Association, the Academy of Family Physicians, the Nutrition Screening Initiative, and the National Alliance for Infusion Therapy to meet with Senator Thomas Harkin (D-Iowa) about the i
HIV-associated malnutrition. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Physicians Assoc AIDS Care. 1995 Jan;2(1):12-5. Unique Identifier : AIDSLINE AIDS/95700083; Kotler DP; Columbia University, Medical Center, College of Physicians and; Surgeons, New York, NY 10032.; The author reviews the role of malnutrition in HIV infection. He hypothesizes that malnutrition contributes to complications encountered by an HIV-infected person and malnutrition problems are independent of the degree of immune depletion. Healthcare professionals have placed little emphasis on nutritional education.
AIDS-associated anorexia. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Physicians Assoc AIDS Care. 1995 Jan;2(1):19-22. Unique Identifier : AIDSLINE AIDS/95700084; Beal J; Flynn N; University of California Davis, Medical Center, Internal Medicine; Department, Division of General Medicine, AIDS and Related; Disorders Clinic, Sacramento, CA 95817.; The pathogenesis of AIDS-associated anorexia involves any one or a combination of several factors, including malnutrition and nutrient abnormalities, gastrointestinal dysfunction, metabolic dysfunctions, neuropsychiatric disturbances, economic and sociocultural factors, and anorexigenic medications. Appropriate manage
Recent results with Megace. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Physicians Assoc AIDS Care. 1995 Jan;2(1):22-3. Unique Identifier : AIDSLINE AIDS/95700085; Flynn N; University of California Davis, Medical Center, Internal Medicine; Department, Division of General Medicine, AIDS and Related; Disorders Clinic, Sacramento, CA 95817.; HIV-related weight loss can be broken into four categories: 1) episodic weight loss accompanying acute infections or malignancies; 2) intermittent anorexia; 3) the late, accelerated weight loss phase associated with a 10 -20 percent loss of body weight; and 4) the terminal phase of HIV disease in which weight loss has
Update on vitamins, minerals, and the carotenoids. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Physicians Assoc AIDS Care. 1995 Jan;2(1):24-9. Unique Identifier : AIDSLINE AIDS/95700086; Coodley G; Oregon Health Sciences University, Division of Infectious; Diseases, HIV / AIDS Program, AIDS Education and Training Center,; Portland, OR 97201.; Various vitamins and minerals play roles in HIV infection. There is evidence that a number of HIV+ patients suffer from deficiencies in vitamins B12, B6, A, and D; folate, zinc and selenium; and carotenoids such as beta-carotene, betacryptoxanthin, and lutein. Vitamin B12 deficiency can result in
Pharmacologic agents used for nutritional disorders of HIV/AIDS. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Physicians Assoc AIDS Care. 1995 Jan;2(1):30-2. Unique Identifier : AIDSLINE AIDS/95700087; Rosen GH; University of Maryland, School of Medicine, College Park, MD; 20742.; Weight loss in the HIV patient appears to result from the interplay of poor nutritional intake, altered metabolism, and malabsorption. Rapid weight loss, defined as greater than 4 kg in four months or less, is associated with non-gastrointestinal secondary infection; and slower weight loss is typically associated with
Kaposi's sarcoma: possible Foscarnet treatment? Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Jan 20;(No 215):4-5. Unique Identifier : AIDSLINE AIDS/95700105; James JS; Foscarnet (Foscavir), an antiviral used to treat CMV ( cytomegalovirus ) infection, is also used to treat acyclovir-resistant herpes simplex and all other herpesviruses. Foscarnet, an expensive treatment, has serious side effec
1995 outlook: research strategy. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Jan 20;(No 215):5-7. Unique Identifier : AIDSLINE AIDS/95700106; James JS; There are more opportunities for progress toward improvement in AIDS/HIV treatment. The tools for research are better; there are safe, rapid, low-cost, high-quality treatment trials; and there are more cases of improvement in people with HIV or AIDS. However, no one knows how long the improvements will last. Success s
Protease inhibitors: where are they now? Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Issues. 1995 Jan;9(1):1-7. Unique Identifier : AIDSLINE AIDS/95700108; Gold D; Loftus R; Protease inhibitors block HIV by binding with its protease enzyme and it is hoped that they will be more potent and less toxic than nucleoside analogs. The companies Hoffmann-La Roche , Merck, Abbott, Searle ,
Underground protease inhibitor. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Issues. 1995 Jan;9(1):2. Unique Identifier : AIDSLINE AIDS/95700109; Financiers have invested $100,000 in production laboratories to produce an underground version of the Merck protease inhibitor (L-524). Buyers clubs considering producing L-524 will have to consider the high prices and ways to ration the limited supply. The problems of synthesizing L-524 are complex. Merck, by not cre
Virus sidesteps convergent therapy. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Issues. 1995 Jan;9(1):6. Unique Identifier : AIDSLINE AIDS/95700110; The ambiguous results from ACTG 241, a federally funded clinical trial, may mark the end for the convergent combination therapy . The study enrolled volunteers with CD4 counts between 50 and 350 who had received at least six months of nucleoside analog therapy. They wer
Hydroxyurea, a potential new anti-HIV agent. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Issues. 1995 Jan;9(1):7-9. Unique Identifier : AIDSLINE AIDS/95700116; Torres G; Published evidence from the U.S. and Europe supports the effect of the anticancer drug hydroxyurea against HIV-1, and its potential synergistic effect with ddl. Approved as an oral chemotherapeutic agent for leukemia and other cancers, hydroxyurea acts as a radical free quencher, inhibiting the cellular enzyme ribonuc
Human trial for gene therapy. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Issues. 1995 Jan;9(1):9. Unique Identifier : AIDSLINE AIDS/95700117; Chang HE; Scientists will undertake the first clinical study using gene therapy against HIV by giving cells the gene for a double ribozyme, which cleaves HIV s genetic RNA material at two distinct sites. The double ribozyme has exhibited more potent anti-HIV effects in cell cultures than the single ribozyme, the U5 hairpin, use
Human growth hormone available for AIDS wasting. [news] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Issues. 1995 Jan;9(1):9-11. Unique Identifier : AIDSLINE AIDS/95700118; Gilden D; The Food and Drug Administration has approved a treatment IND allowing Serono Laboratories to distribute its experimental version of human growth hormone (HGH) to people with AIDS-related wasting syndrome. To receive HGH, a person with AIDS must have lost 10 percent of normal body weight without apparent cause, and mu
Oral ganciclovir approved. [news] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Issues. 1995 Jan;9(1):10. Unique Identifier : AIDSLINE AIDS/95700119; Gold D; The Food and Drug Administration has approved oral ganciclovir (Cytovene) as a maintenance therapy for cytomegalovirus ( CMV ) infections of the retina. As an alternative to the intravenous form of the drug, oral ganciclovir wo
Uncharitable donations? [news] Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Issues. 1995 Jan;9(1):10. Unique Identifier : AIDSLINE AIDS/95700120; Gold D; PIMED, a French health care advocacy group, has reported that donations of unused prescription drugs can often cause more harm than good. Donated medications are often expired, substandard, or useless, and are usually unaccompanied by prescribing information in a locally-understood language. According to the
KS: a new drug and, maybe, a new bug. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: Treat Issues. 1995 Jan;9(1):11-12. Unique Identifier : AIDSLINE AIDS/95700121; Gilden D; A clinical trial of DOX-SL, involving 500 patients at 45 sites around the country, will be open to people with Kaposi s sarcoma (KS) who have failed or are intolerant to systemic combination chemotherapy involving at least 2 drugs, not including alpha interferon. DOX-SL is a special long-lasting version of the standar
Cytovene capsules approved. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: J Physicians Assoc AIDS Care. 1995 Jan;2(1):15. Unique Identifier : AIDSLINE AIDS/95700122; Cytovene (ganciclovir) capsules were approved by the Food and Drug Administration ( FDA ) on December 22, 1994 as an alternative to the intravenous formulation for maintenance therapy of CMV retinitis in patients with HIV disease.
Hyperamylasemia and facial swelling in an HIV-infected man. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Clin Care. 1995 Jan;7(1):7, 9. Unique Identifier : AIDSLINE AIDS/95700013; Zuger A; A 35-year old HIV-infected man who has been on AZT and TMP-SMX for five years with CD4 cell counts fluctuating between 150/mm3 and 200/mm3 for the last three years is presented in this case history. Because of elevated serum amylase, he was advised no
New information on HIV rapid turnover--what does it mean? Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.: AIDS Treat News. 1995 Jan 20;(No 215):1-4. Unique Identifier : AIDSLINE AIDS/95700104; James JS; The results of small, rapid clinical trials, reported in January in newspapers and journals, have led to the discovery that the turnover of new virus in the body is far more rapid than previously believed. The findings suggest that the immune system might have the ability to recover if HIV reproduction could be stoppe
HIV-infection in the autopsy material (Hamburg 1984-1989).: Acta Morphol Hung. 1992;40(1-4):103-11. Unique Identifier : AIDSLINE MED/95149743; Koops E; Lieske K; Puschel K; Janssen W; Institute of Forensic Medicine, University of Hamburg, Germany.; 77 HIV-positive corpses were autopsied at the Institute of Forensic Medicine in Hamburg (in cooperation with the Bernhard-Nocht Institute) from August 1984 until September 31st, 1989. In the clinical autopsies (29 cases) the patients had always shown manifest AIDS symptoms, while 90% of the HIV-infected forensic autop
Absence of HTLV-I DNA sequences in cutaneous T-cell lymphoma/mycosis fungoides.: Acta Morphol Hung. 1992;40(1-4):249-55. Unique Identifier : AIDSLINE MED/95149755; Lapis P; Freeman J; Bitter MA; Golitz LE; Department of Pathology and Dermatology, University of Colorado; Health Sciences Center, Denver.; Recently, the presence of deleted forms of the HTLV-I provirus was described in 6 out of 6 cases of CTCL. We investigated whether the presence of these viral genomes could be verified in 20 patients with CTCL using the polymerase chain reaction (PCR) and Southern blot analysis. Only one of the 20 cases showed a band c
Intrinsic activity of human immunodeficiency virus type 1 protease heterologous fusion proteins in mammalian cells.: DNA Cell Biol. 1995 Jan;14(1):15-23. Unique Identifier : AIDSLINE MED/95134352; Arrigo SJ; Haines JK; Huffman KM; Department of Microbiology and Immunology, Medical University of; South Carolina, Charleston 29425-2230.; We have generated various mammalian expression constructs that produce fusion proteins of human immunodeficiency virus type 1 (HIV-1) protease (PR) with the HIV-1 Nef protein. The expression of these proteins is inducible by the HIV-1 Tat protein. High-level expression of proteolytically active PR was produced from PR
Isolation and identification of Encephalitozoon hellem from an Italian AIDS patient with disseminated microsporidiosis.: APMIS. 1994 Nov;102(11):817-27. Unique Identifier : AIDSLINE GENBANK/L19070; Scaglia M; Sacchi L; Gatti S; Bernuzzi AM; Polver P de P; Piacentini I; Concia E; Croppo GP; da Silva AJ; Pieniazek NJ; et al; Laboratory of Clinical Parasitology, Pavia University-IRCCS San; Matteo, Italy.; Microsporidia are primitive mitochondria-lacking spore-forming eukaryotic protozoa that infect a wide variety of animals and also humans. Of the five genera (Encephalitozoon, Enterocytozoon, Septata, Nosema and Pleistophora) that cause infections in humans, Enterocytozoon bieneusi, Septata intestinalis, and Encephalit
Effects of dideoxyinosine and dideoxycytidine on the intracellular phosphorylation of zidovudine in human mononuclear cells.: Br J Clin Pharmacol. 1994 Oct;38(4):323-8. Unique Identifier : AIDSLINE MED/95134619; Veal GJ; Wild MJ; Barry MG; Back DJ; Department of Pharmacology and Therapeutics, University of; Liverpool.; 1. Zidovudine (3 -azido-2 ,3 -dideoxythymidine; AZT ; ZDV) is a dideoxynucleoside analogue active against human immunodeficiency virus (HIV). We are currently investigating the intracellular metabolism of ZDV to its putative active triphosphate form (Z
World AIDS day. Fighting for families.: Nurs Stand. 1994 Nov 30-Dec 6;9(10):24-5. Unique Identifier : AIDSLINE MED/95134636; Alderman C
Increased levels of soluble CD8 and CD4 in patients with infectious mononucleosis.: Br J Haematol. 1995 Jan;89(1):47-54. Unique Identifier : AIDSLINE MED/95134680; Yoneyama A; Nakahara K; Higashihara M; Kurokawa K; First Department of Internal Medicine, Faculty of Medicine,; University of Tokyo, Japan.; Plasma levels of soluble CD8 (sCD8) and soluble CD4 (sCD4) in 44 patients with infectious mononucleosis (IM) were studied. A marked increase in sCD8 (22366 +/- 2702 U/ml; control: 219 +/- 10 U/ml; P
Young gay men and HIV: running the risk? [published erratum appears in AIDS Care 1995;7(1):108]: AIDS Care. 1994;6(4):371-8. Unique Identifier : AIDSLINE MED/95134772; Ridge DT; Plummer DC; Minichiello V; Sexual Health Research Group, School of Behavioural Health; Sciences, La Trobe University, Bundoora, Victoria, Australia.; HIV research often depicts adolescents and youth as having unique qualities which predispose them to sexual risk. Yet, the evidence points to unsafe sexual behaviour as not being socially uniform. At a time when the idea of risk groups for HIV is being subjected to increasing public scrutiny, researchers also o
Identifying helpful and unhelpful behaviours of loved ones: the PWA's perspective.: AIDS Care. 1994;6(4):379-92. Unique Identifier : AIDSLINE MED/95134773; Hays RB; Magee RH; Chauncey S; Center for AIDS Prevention Studies, University of California, San; Francisco 94105.; Twenty-five gay men with AIDS were interviewed about their social support networks and asked to describe specific interpersonal exchanges with network members which they perceived to be helpful and unhelpful. Content-analysis of responses revealed 12 main categories of helpful behaviours (providing encouragement, compo
Individual differences associated with high-risk sexual behaviour: implications for intervention programmes.: AIDS Care. 1994;6(4):393-7. Unique Identifier : AIDSLINE MED/95134774; Seal DW; Agostinelli G; Psychology Department, University of New Mexico, Albuquerque.; Simpson & Gangestad s (1991) sociosexual orientation inventory measures people s willingness to engage in uncommitted sexual relations. People with unrestricted sociosexual orientations report more casual sex encounters, and multiple and concurrent sexual partners, factors known to increase the risk for exposure to
When patients first suspect and find out they are infected with the human immunodeficiency virus: implications for prevention [published erratum appears in AIDS Care 1995;7(1):107]: AIDS Care. 1994;6(4):399-405. Unique Identifier : AIDSLINE MED/95134775; Wenger NS; Kusseling FS; Beck K; Shapiro MF; Department of Medicine, University of California, Los Angeles; 90024-1736.; To evaluate how individuals infected with the human immunodeficiency virus (HIV) became aware of their infection, when they first suspected they were infected with HIV and factors associated with suspecting HIV infection, we surveyed 227 patients at an urban outpatient HIV clinic. Though nearly all patients acknowledg
The Mental Adjustment to HIV scale: measurement and dimensions of response to AIDS/HIV disease.: AIDS Care. 1994;6(4):407-11. Unique Identifier : AIDSLINE MED/95134776; Ross MW; Hunter CE; Condon J; Collins P; Begley K; Center for Health Promotion Research and Development, School of; Public Health, University of Texas, Houston 77225.; Attitudes of people with HIV disease towards HIV have seldom been measured. However, a well-established scale to measure attitudes toward cancer in those with the disease, the 38-item Mental Adjustment to Cancer (MAC) scale was modified to assess adjustment to HIV disease. We administered the scale to 107 Australian m
Changes in public knowledge and attitudes to HIV/AIDS in Wales, 1987 to 1992.: AIDS Care. 1994;6(4):413-21. Unique Identifier : AIDSLINE MED/95134777; Roberts C; Blakey V; Smith C; Health Promotion Wales, Cardiff, UK.; This paper presents information on changes in public knowledge and attitudes to HIV/AIDS in Wales between 1987 and 1992. The results indicate that throughout this period the majority of adults in Wales were aware of the high risk of infection from sexual intercourse and sharing needles with, and coming into contact wi
'We just want to be a normal family...'. Paediatric HIV/AIDS services at an inner-London teaching hospital.: AIDS Care. 1994;6(4):423-33. Unique Identifier : AIDSLINE MED/95134778; Barrett G; Victor CR; Department of Public Health, Kensington & Chelsea and Westminster; Commissioning Agency, London, UK.; The nature of the HIV epidemic in the UK is changing with the increasing number of infected women and children. This recent onset means that there are few data about the specific problems of HIV in families. This study examines current issues in service provision to HIV infected children and their families at an inner
Perceived risk of becoming infected with HIV by donating blood and changes in reported blood donation practice among the Scottish general public 1989-1992.: AIDS Care. 1994;6(4):435-42. Unique Identifier : AIDSLINE MED/95134779; Robertson BJ; McQueen DV; Research Unit in Health and Behavioural Change, University of; Edinburgh, Scotland, UK.; A total of 17,537 respondents aged 18-60 and resident in Edinburgh and Glasgow were interviewed between January 1989 and May 1992 as part of a large scale continuous monitoring survey of lifestyles and health. A computer assisted telephone interview (CATI) system was used. Respondents were chosen randomly from househo
HIV-1 infection at two public psychiatric hospitals in New York City.: AIDS Care. 1994;6(4):443-52. Unique Identifier : AIDSLINE MED/95134780; Cournos F; Horwath E; Guido JR; McKinnon K; Hopkins N; Washington Heights Community Service Research Office, New York; State Psychiatric Institute, NY 10032.; Seroprevalence for HIV-1 was anonymously evaluated between November 1989 and July 1991 among severely mentally ill patients at two public psychiatric hospitals in New York City. The study population consisted of new admissions and long-stay patients aged 18-59. Of 1116 eligible patients, usable samples were obtained f
A method for determining rates of sexual activity in schoolchildren.: AIDS Care. 1994;6(4):453-7. Unique Identifier : AIDSLINE MED/95134781; Tripp JH; Mellanby AR; Phelps FA; Curtis HA; Crichton NJ; Department of Child Health, Postgraduate Medical School,; University of Exeter, UK.; This report details a novel methodology for determining rates of sexual activity in schoolchildren. The method has been found to be acceptable to schools, parents and students, it receives a high level of co-operation, a low (1%) parental withdrawal, and a low number (3%) of inadequate responses. A marked advantage of
STD knowledge and behaviours among clients of female sex workers in Bali, Indonesia.: AIDS Care. 1994;6(4):459-75. Unique Identifier : AIDSLINE MED/95134782; Fajans P; Wirawan DN; Ford K; School of Public Health, University of Michigan 48109-2029.; This study investigated knowledge, beliefs, and practices related to STDs and AIDS among clients of low price sex workers in Bali, Indonesia . These men are at high risk of STD and HIV transmission. They have poor knowledge of the basic concepts of STD and HIV transmission and pr
World Health Organization Global AIDS Statistics.: AIDS Care. 1994;6(4):490-4. Unique Identifier : AIDSLINE MED/95134783
Transfer of an anti-HIV-1 ribozyme gene into primary human lymphocytes.: Hum Gene Ther. 1994 Sep;5(9):1115-20. Unique Identifier : AIDSLINE MED/95134789; Leavitt MC; Yu M; Yamada O; Kraus G; Looney D; Poeschla E; Wong-Staal F; Department of Medicine, University of California, San Diego, La; Jolla 92093-0665.; We reported previously that human CD4+ T cell lines stably expressing a hairpin ribozyme targeted to the human immunodeficiency virus type 1 (HIV-1) U5 leader sequence were resistant to challenge with diverse HIV-1 viral clones and clinical isolates (Yamada et al., 1994). To simulate more closely the in vivo infection
Small noncleaved cell lymphoma and leukemia in adults. A retrospective study of 65 adults treated with the LMB pediatric protocols.: Blood. 1995 Feb 1;85(3):664-74. Unique Identifier : AIDSLINE MED/95134897; Soussain C; Patte C; Ostronoff M; Delmer A; Rigal-Huguet F; Cambier N; Leprise PY; Francois S; Cony-Makhoul P; Harousseau JL; et al; Institut Gustave Roussy, Villejuif, France.; In France , more than 80% of children with Burkitt s lymphoma or Burkitt s leukemia (ALL3) are now cured with the LMB (B-cell non-Hodgkin s lymphoma and B-ALL) protocols of the Societe Francaise d Oncologie Pediatrique, but so far, poor results h
International Symposium on HIV Infection in Children. Valencia, Spain.: Acta Paediatr Suppl. 1994 Aug;400:1-110. Unique Identifier : AIDSLINE MED/95135005
The global HIV pandemic.: Acta Paediatr Suppl. 1994 Aug;400:1-4. Unique Identifier : AIDSLINE MED/95135006; Stoneburner RL; Sato P; Burton A; Mertens T; Global Programme on AIDS, World Health Organization, Geneva,; Switzerland.; The paper reviews the distribution, transmission patterns, and likely impacts of the HIV pandemic at the beginning of 1993. As of early 1993, a cumulative total of 611,589 cases of AIDS were reported to the World Health Organization (WHO); however, because of less than complete diagnos
Mass media and HIV epidemia in the United States.: Acta Paediatr Suppl. 1994 Aug;400:102-3. Unique Identifier : AIDSLINE MED/95135007; Squires S
The role of UNESCO in school-based education for the prevention of AIDS.: Acta Paediatr Suppl. 1994 Aug;400:104-5. Unique Identifier : AIDSLINE MED/95135008; Bahri S; Isaksson A; Barthes AM; Saldari L; Westlund G; UNESCO, Section of Preventive Education, Paris, France.
Maternal and pediatric AIDS in the United States: the current situation and future research directions.: Acta Paediatr Suppl. 1994 Aug;400:106-10. Unique Identifier : AIDSLINE MED/95135009; Blank A; Mofenson LM; Willoughby A; Yaffe SJ; National Institute of Child Health and Human Development,; National Institutes of Health, Bethesda 20892.; The epidemic of HIV infection and disease in women, adolescents and children represents a complexly intertwined biological and social challenge to health care workers and researchers alike. When considering various issues in confronting this epidemic, women must be viewed as individuals important in their own right, a
Epidemiology of HIV infection in children in Italy. The Italian Register for HIV Infection in Children.: Acta Paediatr Suppl. 1994 Aug;400:15-8. Unique Identifier : AIDSLINE MED/95135010; As of April 1992, 2337 children born to HIV-1-positive mothers were recorded by our multicentre study. Another 131 children were infected by contaminated blood products, while in 5 cases the risk factor remained unknown, as their personal history was lacking. The number of perinatally exposed children increased expone
Epidemiological and serological studies in HIV-infected Ethiopian immigrants to Israel.: Acta Paediatr Suppl. 1994 Aug;400:19-21. Unique Identifier : AIDSLINE MED/95135011; Pollack S; Ben-Porath E; Fuad B; Raz R; Etzioni A; Department of Clinical Immunology, Rambam Medical Center, Bruce; Rappaport Faculty of Medicine, Technion-Israel Institute of; Technology, Haifa.; In the last 10 years, Ethiopian Jews have immigrated to Israel in large numbers. Up to 1990 they came directly from their remote villages in northern Ethiopia and no HIV infection was detected in the several thousands that came. In contrast, 1.74% of approximately 14,000 new immigr
Prevention program of HIV infection in Ethiopian new immigrants to Israel.: Acta Paediatr Suppl. 1994 Aug;400:22-4. Unique Identifier : AIDSLINE MED/95135012; Etzioni A; Pollack S; Ben-Ishai Z; Department of Pediatrics, Rambam Medical Center, Bruce Rappaport; Faculty of Medicine, Technion-Israel Institute of Technology,; Haifa.; In 1991, more than 15,000 Ethiopian Jews immigrated to Israel after spending more than a year in Addis Ababa. They came from remote villages and had had no contact with modern medicine for centuries. About 2% of these new immigrants were found to be HIV positive. Their completely d
Mother-to-child HIV-1 transmission: quantitative assessment of viral burden as a diagnostic tool and prognostic parameter in HIV-1-infected children.: Acta Paediatr Suppl. 1994 Aug;400:25-8. Unique Identifier : AIDSLINE MED/95135013; De Rossi A; Ometto L; Zanotto C; Salvatori F; Masiero S; Mammano F; Chieco-Bianchi L; Institute of Oncology, University of Padua, Italy.; Polymerase chain reaction was performed in 251 infants born to HIV-1-seropositive mothers to diagnose HIV-1 infection. Assay specificity was invariably > 95%, regardless of age at testing, while sensitivity ranged from 15% in neonates (within 48 h of birth) to > 95% in infants over 1 month of age. Evaluation of viral
Application of the polymerase chain reaction for the detection of HIV in specimens from newborn screening programs.: Acta Paediatr Suppl. 1994 Aug;400:29-30. Unique Identifier : AIDSLINE MED/95135014; Comeau AM; Theobald Smith Research Institute, Inc., State Laboratory; Institute, Jamaica Plain, MA.; The use of the polymerase chain reaction (PCR) permits detection of HIV proviral DNA in the universally collected dried blood spot specimens of newborn screening programs. Detection of HIV proviral DNA among the annual cohorts of seropositive specimens from ongoing anonymous newborn HIV seroprevalence studies can prov
Autoimmune phenomena in children with human immunodeficiency virus infection and acquired immunodeficiency syndrome.: Acta Paediatr Suppl. 1994 Aug;400:31-4. Unique Identifier : AIDSLINE MED/95135015; Rodriguez-Mahou M; Lopez-Longo J; Lapointe N; Carreno L; Grau R; Gurbindo D; Fernandez-Cruz E; Department of Immunology, Hospital General Universitario Gregorio; Maranon, Madrid, Spain.; We have studied sera from 44 children with Human Immunodeficiency Virus infection and Acquired Immunodeficiency Syndrome using immunoblotting, radioimmunoassay, enzymoimmunoassay and indirect immunofluorescence. We have detected a low incidence of antinuclear (2.9%), anti-reticulin (2.9%) and anti-smooth muscle (14.7%
Evolution of immunological abnormalities in HIV infection by vertical transmission.: Acta Paediatr Suppl. 1994 Aug;400:35-8. Unique Identifier : AIDSLINE MED/95135016; Espanol T; Caragol I; Bertran JM; Immunology Unit, C.S. Valle Hebron, Barcelona, Spain.; Forty-four children infected through vertical transmission, from a total of 146 born to HIV-positive mothers, were studied. Immunological data were analysed and compared with those of the noninfected children. Two transmission patterns emerge from the clinical and immunological characteristics: (i) infants infected du
HIV mass screening of infants and mothers: historical, technical, and practical issues.: Acta Paediatr Suppl. 1994 Aug;400:39-42. Unique Identifier : AIDSLINE MED/95135017; Grady GF; Theobald Smith Research Institute, State Laboratory Institute,; Jamaica Plain, MA.; Screening groups of anonymous infants for HIV antibody, as an index of maternal infection rates, has been a widely used seroepidemiological method since being introduced in 1986 in Massachusetts (USA). One shortcoming has been the applicability only to parturient women, thus necessitating corrections for fertility rat
Vertical transmission of HIV infection.: Acta Paediatr Suppl. 1994 Aug;400:43-5. Unique Identifier : AIDSLINE MED/95135018; Newell ML; Peckham C; Department of Paediatric Epidemiology, Institute of Child Health,; London, UK.; Transmission of HIV infection from mother to child may occur before, during or after delivery. Estimates of the rate of vertical transmission range from 15-20% in Europe to 25-35% in Africa. Mother-to-child transmission is associated with progression of disease in the mother, severe prematurity and breastfeeding. The
The opportunistic and bacterial infections associated with pediatric human immunodeficiency virus disease.: Acta Paediatr Suppl. 1994 Aug;400:46-50. Unique Identifier : AIDSLINE MED/95135019; Nicholas SW; Department of Pediatrics, College of Physicians and Surgeons of; Columbia University, New York City.; Opportunistic and bacterial infections remain the leading causes of death of Human Immunodeficiency Virus-infected children, despite recent advances in the diagnosis of HIV infection during early infancy; antiretroviral therapies; advances in the treatment of some infections; an improved understanding of the cellular
Epidemiology of pediatric human immunodeficiency virus infection in the United States.: Acta Paediatr Suppl. 1994 Aug;400:5-7. Unique Identifier : AIDSLINE MED/95135020; Rogers MF; Caldwell MB; Gwinn ML; Simonds RJ; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, GA.; Human Immunodeficiency Virus (HIV) infection is a growing problem for children worldwide. As of 31 December 1992, 4249 children with Acquired Immunodeficiency Syndrome (AIDS) under 13 years of age had been reported to the US Centers for Disease Control and Prevention (CDC). HIV is transmitted to children predominantly
Human immunodeficiency virus type 1 infection and breast milk. The Italian Register for HIV Infection in Children.: Acta Paediatr Suppl. 1994 Aug;400:51-8. Unique Identifier : AIDSLINE MED/95135021; Major questions are whether mothers infected with the Human Immunodeficiency Virus type 1 (HIV-1) transmit the virus through breast milk and the magnitude of the additional transmission risk. The demonstration of a dose-response effect is an epidemiological method to demonstrate causality. Thus, a study was carried ou
Pediatric HIV infection: neurologic and neuropsychologic findings.: Acta Paediatr Suppl. 1994 Aug;400:59-62. Unique Identifier : AIDSLINE MED/95135022; Fowler MG; Vaccine Trials and Epidemiology Branch, NIAID, NIH, Bethesda.; Neurologic and neuropsychologic findings are early and important prognostic indicators of symptomatic HIV disease among infants and young children. The most common presentations include progressive encephalopathy, loss of motor milestones, and corticospinal tract abnormalities. It is hypothesized that, in some instanc
Antiretroviral therapy for children.: Acta Paediatr Suppl. 1994 Aug;400:63-9. Unique Identifier : AIDSLINE MED/95135023; Krasinski K; Department of Pediatrics, New York University Medical Center, New; York.; Advances in the development of antiviral drugs have been rapid and dramatic. Since the recognition of HIV-1 as the cause of AIDS in 1984, and improved understanding of retroviral replication and pathogenesis, three antiviral drugs, Zidovudine, Didanosine, and Zalcitabine, have been developed to the point of routine us
The use of antibiotics in the treatment and prevention of infection in HIV-infected children.: Acta Paediatr Suppl. 1994 Aug;400:70-2. Unique Identifier : AIDSLINE MED/95135024; Ruga E; Giaquinto C; Cozzani S; Giacomelli A; Pagliaro A; Mazza A; De Manzini A; Laverda AM; D'Elia R; Department of Paediatrics, University of Padua, Italy.; Children with HIV infection have an unusual susceptibility to bacterial infection, related to several immune abnormalities. Selection of initial antibiotic therapy must be individualized in these children. Patients with community-acquired disease are most likely to have infection by polysaccharide-encapsulated bacteri
HIV vaccine development and clinical trials.: Acta Paediatr Suppl. 1994 Aug;400:73-7. Unique Identifier : AIDSLINE MED/95135025; Hoff R; McNamara J; Fowler M; McCauley M; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, MD.; The magnitude of HIV pandemic has made the development of HIV vaccines an urgent biomedical research priority. Although the biologic problems in designing a vaccine for a chronic viral infection like HIV are formidable, there has been encouraging progress. More than a dozen first generation prophylactic HIV vaccine ca
Longitudinal follow-up studies.: Acta Paediatr Suppl. 1994 Aug;400:78-80. Unique Identifier : AIDSLINE MED/95135026; Peckham C; Newell ML; Department of Paediatric Epidemiology, Institute of Child Health,; London, UK.; A longitudinal study should be undertaken only when there is a clear reason to justify this and a reasonable chance of achieving the objectives. A multidisciplinary approach is often required, and continuity of staff and long-term collaboration with colleagues are important for their success. A longitudinal approach i
Epidemiology of HIV infection in children in Europe.: Acta Paediatr Suppl. 1994 Aug;400:8-14. Unique Identifier : AIDSLINE MED/95135027; Canosa CA; Children's Hospital La Fe, Valencia, Spain.; In Europe the Human Immunodeficiency Virus (HIV) epidemic in children is an important public health problem. Reliable epidemiological information varies widely among countries, and there is no standard method to document the pandemia. By September 1992, a total of 81,849 AIDS cases were identified.
Behavioral risks for HIV in adolescents.: Acta Paediatr Suppl. 1994 Aug;400:81-7. Unique Identifier : AIDSLINE MED/95135028; Moss N; Demographic and Behavioral Sciences Branch, National Institute of; Child Health and Human Development, Bethesda, MD 20892.; A psychosocial perspective on adolescent risk behavior is used to highlight aspects of psychological development and social environment that are relevant to sexual activity and substance use. Differences in behavior are also related to factors such as age and gender that have biological, developmental, and demographic
Adolescents and HIV infection: a clinician's perspective.: Acta Paediatr Suppl. 1994 Aug;400:88-94. Unique Identifier : AIDSLINE MED/95135029; D'Angelo LJ; Children's National Medical Center, Washington, DC 20010.; Increasing concern in the United States has centered on HIV infection in adolescents. While less than 0.4% of all reported cases of AIDS are reported in adolescents 13-19 years of age, it is speculated that upwards of 20% of all AIDS cases have acquired their infection as teenagers. Mo
Policy, ethics, and reproductive choice: pregnancy and childbearing among HIV-infected women.: Acta Paediatr Suppl. 1994 Aug;400:95-8. Unique Identifier : AIDSLINE MED/95135030; Kass NE; Department of Health Policy and Management, Johns Hopkins School; of Public Health, Baltimore, MD 21205.; As the numbers of women infected with HIV continue to increase, there are more calls for women who are HIV-infected not to have children, or for policies to be created that limit or try to influence the reproductive choices of HIV-infected women. Although motivated by legitimate concerns, such potential policies may b
Paediatric AIDS: a new child abuse.: Acta Paediatr Suppl. 1994 Aug;400:99-101. Unique Identifier : AIDSLINE MED/95135031; Oletto S; Giaquinto C; Seefried M; Ruga E; Cozzani S; Mazza A; De Manzini A; D'Elia R; Zacchello F; Department of Paediatrics, University of Padua, Italy.; In relation to youth rights, a new view has been created in recent decades that is included in the fundamental law of the child: the recognition of the right to education and the chance to develop a mature personality capable of creativity and liberty. Because of HIV infection it is very important to pay particular at
Successful treatment of postherpetic neuralgia with oral ketamine.: Clin J Pain. 1994 Sep;10(3):240-2. Unique Identifier : AIDSLINE MED/95135041; Hoffmann V; Coppejans H; Vercauteren M; Adriaensen H; Department of Anesthesia, University Hospital of Antwerpen,; Edegem, Belgium.; OBJECTIVE: To demonstrate the possibilities of the use of oral ketamine in the treatment of postherpetic neuralgia. SETTING: A pain clinic in a university hospital. PATIENT: A patient with postherpetic neuralgia of the ophthalmic nerve. INTERVENTION: Subcutaneous and later oral ketamine after classical treatment had f
Research shows how HIV exhausts the body [news]: BMJ. 1995 Jan 21;310(6973):145. Unique Identifier : AIDSLINE MED/95135225; Connor S
WHO's special programmes: undermining from above.: BMJ. 1995 Jan 21;310(6973):178-82. Unique Identifier : AIDSLINE MED/95135246; Godlee F; Despite the World Health Organisation s spoken commitment to developing integrated primary health care, its most visible and successful activities are not integrated within countries; they are its disease specific intervention programmes, such as the Global Programme on AIDS and the programmes for the control of diarr
[Suspected gold-induced pneumonitis complicating polyarthritis in human immunodeficiency virus infection (letter)]: Rev Rhum Ed Fr. 1994;61(7-8):558-9. Unique Identifier : AIDSLINE MED/95135391; Leone J; Vallerand H; Pennaforte JL; Colmet-Daage JF; Etienne JC
The family in Thailand and drug demand reduction: problems of urban Thai society in transition.: Bull Narc. 1994;46(1):45-66. Unique Identifier : AIDSLINE MED/95135401; Spielmann S; Graduate Program in Criminology and Criminal Justice, Faculty of; Social Sciences and Humanities, Mahidol University, Bangkok.; Thailand is undergoing ever-accelerating socio-economic transformation which exercises tremendous strains on its basic social institution, the Thai family. The family has traditionally exercised firm control over its members, thus ensuring cohesion and conformity to social norms.
The Clinical Center Nursing Department at the National Institutes of Health (NIH) Bethesda, MD.: Nurs Spectr (Wash D C). 1994 Nov 14;4(23):7. Unique Identifier : AIDSLINE MED/95135618
HIV-induced stupor treated with ECT.: Convuls Ther. 1994 Sep;10(3):232-5. Unique Identifier : AIDSLINE MED/95135797; Kessing L; LaBianca JH; Bolwig TG; Department of Psychiatry, Rigshospitalet, University of; Copenhagen, Denmark.; A 27-year-old man positive for human immunodeficiency virus (HIV) presented with severe depressive stupor, peripheral neuropathy , and myelopathy. The onset of psychiatric symptoms, closely followed by neurological symptoms, without other possible somatic etiology sugg
Not everyone with AIDS gets timely health services.: Minor Nurse Newsl. 1994 Nov-Dec;1(6):1. Unique Identifier : AIDSLINE MED/95135968
L-2-oxothiazolidine-4-carboxylic acid (procysteine) inhibits expression of the human immunodeficiency virus and expression of the interleukin-2 receptor alpha chain.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):107-15. Unique Identifier : AIDSLINE MED/95135988; Lederman MM; Georges D; Dando S; Schmelzer R; Averill L; Goldberg D; Department of Medicine, Case Western Reserve University School of; Medicine, Cleveland, OH 44106-4984.; These studies were undertaken to examine the in vitro effects of the cysteine pro-drug L-2-oxothiazolidine-4-carboxylic acid (Procysteine) on human immunodeficiency virus expression. Procysteine inhibited HIV expression in human peripheral blood mononuclear cells as detected by measurement of supernatant core antigen.
Biological and genetic changes in ovine lentivirus strains following passage in isogeneic twin lambs.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):124-33. Unique Identifier : AIDSLINE MED/95135990; Woodward TM; Carlson JO; de la Concha-Bermejillo A; DeMartini JC; Department of Pathology, Colorado State University, College of; Veterinary Medicine and Biomedical Sciences, Fort Collins 80523.; Ovine lentivirus (OvLV) strains vary in cytopathogenicity, but the correlation, if any, between viral cytophenotypes and in vivo pathogenicity is poorly understood. To examine this issue and to evaluate changes in OvLV strains following passage in vivo, biological and genetic characteristics of OvLV isolates following
Toxicity of sulfonamide-reactive metabolites in HIV-infected, HTLV-infected, and noninfected cells.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):134-40. Unique Identifier : AIDSLINE MED/95135991; Rieder MJ; Krause R; Bird IA; Dekaban GA; J. P. Robarts Research Institute, Department of Paediatrics,; Western Ontario, London, Canada.; It has been suggested that the high rates of adverse reactions to sulfonamides among patients with AIDS may be related to an increased sensitivity to reactive drug metabolites among HIV-infected cells. To study this hypothesis, we investigated the toxicity of the hydroxylamine of sulfamethoxazole in HIV-infected and n
Combination therapy with recombinant human soluble CD4-immunoglobulin G and zidovudine in patients with HIV infection: a phase I study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):152-60. Unique Identifier : AIDSLINE MED/95135993; Meng TC; Fischl MA; Cheeseman SH; Spector SA; Resnick L; Boota A; Petrakis T; Wright B; Richman DD; University of California, San Diego.; To determine the effect of zidovudine (ZDV) on the pharmacokinetic disposition of recombinant soluble CD4 immunoglobulin G (rCD4-IgG) and to evaluate the safety and preliminary activity of concurrent administration of ZDV with rCD4-IgG, we undertook an open-label, dose-escalating, 12-week study. The regimens of intrav
The duration of breastfeeding by HIV-1-infected mothers in developing countries: balancing benefits and risks.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):176-81. Unique Identifier : AIDSLINE MED/95135995; Nagelkerke NJ; Moses S; Embree JE; Jenniskens F; Plummer FA; Department of Medical Microbiology, University of Nairobi, Kenya.; How best to advise mothers infected with human immunodeficiency virus type 1 (HIV-1) in developing countries regarding breastfeeding is an important issue that has generated considerable debate. Previous studies have addressed this problem by means of mathematical models, but without considering the issue of the durat
Predictive markers for mother-to-child transmission of HIV-1 in Dar es Salaam, Tanzania.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):182-7. Unique Identifier : AIDSLINE MED/95135996; Bredberg-Raden U; Urassa W; Urassa E; Lyamuya E; Msemo G; Kawo G; Kazimoto T; Massawe A; Grankvist O; Mbena E; et al; Department of Immunology, Swedish Institute for Infectious; Disease Control, Stockholm.; The aim of this study was to determine immunological factors associated with increased risk of mother-to-child transmission of HIV-1 that could be used as predictive markers in Tanzanian women. One hundred and thirty-eight HIV-1-seropositive and 117-seronegative mothers and their newborns were recruited at delivery an
Maternal factors associated with perinatal HIV-1 transmission: the French Cohort Study: 7 years of follow-up observation. The French Pediatric HIV Infection Study Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):188-94. Unique Identifier : AIDSLINE MED/95135997; Mayaux MJ; Blanche S; Rouzioux C; Le Chenadec J; Chambrin V; Firtion G; Allemon MC; Vilmer E; Vigneron NC; Tricoire J; et al; Hopital Kremlin Bicetre, France.; A nationwide, longitudinal study of infants born to human immunodeficiency virus-seropositive mothers has been under way in France since 1986. After 7 years of follow-up observations, we will update our assessment of the transmission rate in France and analyze, on a larger number o
Disseminated Mycobacterium avium infection among HIV-infected patients in Kenya.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):195-8. Unique Identifier : AIDSLINE MED/95135998; Gilks CF; Brindle RJ; Mwachari C; Batchelor B; Bwayo J; Kimari J; Arbeit RD; von Reyn CF; Clinical Research Centre, Kenya Medical Research Institute,; Nairobi.; Previous studies from Africa have been unable to identify disseminated Mycobacterium avium complex (MAC) infection in patients with advanced human immunodeficiency virus (HIV) infection. We performed mycobacterial blood cultures and CD4 counts on 48 symptomatic adults with advanced HIV infection admitted to the hospit
Vitamin A deficiency in non-vitamin-supplemented patients with AIDS: a cross-sectional study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):199-203. Unique Identifier : AIDSLINE MED/95135999; Karter DL; Karter AJ; Yarrish R; Patterson C; Kass PH; Nord J; Kislak JW; Infectious Disease Section, St. Vincent's Hospital, New York; City, New York 10011.; The prevalence of vitamin A deficiency and its association with dietary retinol intake in patients with AIDS was assessed in a cross-sectional study. Sixty eligible patients with AIDS provided serum samples that were analyzed for retinol content. Exclusion criteria included current use of vitamin supplements (57% of t
Illness stage, concurrent medications, and other correlates of low testosterone in men with HIV illness.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):204-7. Unique Identifier : AIDSLINE MED/95136000; Wagner G; Rabkin JG; Rabkin R; New York State Psychiatric Institute, College of Physicians and; Surgeons, Columbia University, New York 10032.; Our objective was to assess whether illness stage, markers of illness progression, and use of medications believed to lower testosterone are associated with low serum testosterone in HIV+ men. Data were available for 234 HIV+ men screened for eligibility for a study of testosterone replacement therapy and/or an antide
HIV prevalence and sexual behavior in a cohort of New York City gay men (aged 18-24).: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):208-11. Unique Identifier : AIDSLINE MED/95136001; Dean L; Meyer I; Columbia University, School of Public Health, Sociomedical; Sciences Division, New York, New York 10032.; An ethnically diverse cohort (n = 174) of New York City gay men (aged 18-24) was studied to determine human immunodeficiency virus (HIV) prevalence and to document sexual behavior patterns. Blood tests of 87 men showed an HIV prevalence of 9%, but only 3% of the previously tested men (n = 77) reported knowledge of a p
Increased tumor necrosis factor-alpha serum levels in patients with HIV wasting syndrome and euthyroid sick syndrome [letter; comment]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):212-4. Unique Identifier : AIDSLINE MED/95136002; Belec L; Meillet D; Gresenguet G; Gherardi RK
Association of HIV and STDs in Haiti: implications for blood banks and HIV vaccine trials [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):214. Unique Identifier : AIDSLINE MED/95136003; Mellon RL; Liautaud B; Pape JW; Johnson WD Jr
Rising HIV-1 prevalence in STD clinic attenders in Jamaica; traumatic sex and genital ulcers as risk factors [letter; comment]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Feb 1;8(2):214-6. Unique Identifier : AIDSLINE MED/95136004; Low NM; Hawkes SJ
HIV care: a changing health care system.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S1-3. Unique Identifier : AIDSLINE MED/95136005; Kahn JO; Smith MD; University of California, San Francisco.
HIV and Managed Care, Henry J. Kaiser Foundation Forum. Menlo Park, California, March 3-4, 1994.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S1-89. Unique Identifier : AIDSLINE MED/95136006
HIV disease and managed care: an overview.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S11-22. Unique Identifier : AIDSLINE MED/95136007; Aseltyne WJ; Cloutier M; Smith MD; Legal Services Division, California Pacific Medical Center, San; Francisco 94115.
The impact of physician financial incentives on high-risk populations in managed care.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S23-30. Unique Identifier : AIDSLINE MED/95136008; Hillman AL; Center for Health Policy, Leonard Davis Institute of Health; Economics, University of Pennsylvania, Philadelphia 19104.; The challenge of managed care is to design a system in which rules and incentives together create a system of checks and balances that ensure both efficient and high-quality care. Incentives need to be administered so that physicians--both primary care providers and specialists--are not forced to choose between person
Quality of care and HIV infection: theory and practice.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S31-44. Unique Identifier : AIDSLINE MED/95136009; Wilson IB; Primary Care Outcomes Research Institute, New England Medical; Center, Boston, MA 02111.; The first section of this article provides a brief, conceptually oriented overview of the state of the art in quality assessment. The second section examines what we know about quality assessment in HIV disease. The third section attempts to synthesize this information and make some practical recommendations. These re
Welcoming presentation to the Henry J. Kaiser Family Foundation Forum on AIDS and Managed Care.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S4-6. Unique Identifier : AIDSLINE MED/95136010; Lawrence DM; Kaiser Foundation Health Plan, Inc./Kaiser Foundation Hospitals,; Oakland, CA.
Developing quality review criteria from standards of care for HIV disease: a framework.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S45-52. Unique Identifier : AIDSLINE MED/95136011; Bozzette SA; Asch S; Health Sciences Program, RAND, Santa Monica, CA 90407-2138.
HIV risk adjustment: issues and proposed approaches.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S53-66. Unique Identifier : AIDSLINE MED/95136012; Kahn JG; Luft H; Smith MD; Institute for Health Policy Studies, University of California,; San Francisco 94109.
AIDS, risk adjustment, and health care financing in New York State.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S67-73. Unique Identifier : AIDSLINE MED/95136013; Padgug RA; Empire Blue Cross and Blue Shield, New York, NY 10027.
Managed care, AIDS, and the politics of risk.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S7-10. Unique Identifier : AIDSLINE MED/95136014; Westmoreland T; U.S. House of Representatives, Subcommittee on Health and; Environment, Washington, DC.
HIV care: a capitated alternative.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S74-9. Unique Identifier : AIDSLINE MED/95136015; Knowlton DL; Knowlton and Associates, Pennington, NJ.; Given sufficient and participatory planning, a cluster of excellence for HIV/AIDS could be designed that could yield benefits to payers, providers, and patients. Such a cluster of excellence would be at risk for all care provided to an enrollment population made up of PWAs and would be globally capitated based upon th
Consumer protections for people living with HIV within systems of managed care.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S80-4. Unique Identifier : AIDSLINE MED/95136016; Schietinger H; Levi J; AIDS Action Foundation, Washington, DC 20009.
HIV and managed care: implications for academic medicine.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995;8 Suppl 1:S85-9. Unique Identifier : AIDSLINE MED/95136017; Makadon HJ; Aseltyne WJ; Harvard Medical School, Boston, MA.
[Cutaneous immune system]: C R Seances Soc Biol Fil. 1994;188(3):207-21. Unique Identifier : AIDSLINE MED/95136104; Schmitt D; INSERM Unite 346, Clinique Dermatologique, Hopital; Edouard-Herriot, Lyon, France.; The skin is not only a physico-mechanical barrier between the environment and the body, but it also functions as an immune organ. The immunological function of epidermis is principally linked to the presence in this tissue of a distinct subpopulation of dendritic cells: the Langerhans cells (LC). LC constitute 2-4% of
[Psychoimmunology and AIDS: a review of the literature]: Can J Psychiatry. 1994 Oct;39(8):404-9. Unique Identifier : AIDSLINE MED/95136200; Montagne G; Lalonde R; Brouillette MJ; Centre hospitalier Pierre Boucher, Longueil, Quebec.; In recent years, several studies have been carried out concerning the effect of psychosocial factors on the course of infection due to the human immunodeficiency virus (HIV). After summarizing the current status of general knowledge in the field of psychoimmunology, this article reviews the results of studies conducte
Human microsporidial infections.: Clin Microbiol Rev. 1994 Oct;7(4):426-61. Unique Identifier : AIDSLINE MED/95136203; Weber R; Bryan RT; Schwartz DA; Owen RL; Department of Medicine, University Hospital, Zurich, Switzerland.; Microsporidia are obligate intracellular spore-forming protozoal parasites belonging to the phylum Microspora. Their host range is extensive, including most invertebrates and all classes of vertebrates. More than 100 microsporidial genera and almost 1,000 species have now been identified. Five genera (Enterocytozoon s
Bronchoscopic diagnosis of pneumonia.: Clin Microbiol Rev. 1994 Oct;7(4):533-58. Unique Identifier : AIDSLINE MED/95136207; Baselski VS; Wunderink RG; Department of Pathology, University of Tennessee, Memphis 38163.; Lower respiratory tract infections are characterized by significant morbidity and mortality but also by a relative inability to establish a specific etiologic agent on clinical grounds alone. With the recognized shortcomings of expectorated or aspirated secretions toward establishing an etiologic diagnosis, clinicians
Sexual behaviour and HIV knowledge among adolescent boys in Zimbabwe.: Cent Afr J Med. 1994 Sep;40(9):245-50. Unique Identifier : AIDSLINE MED/95136325; Campbell B; Mbizvo MT; Department of Obstetrics and Gynaecology, University of Zimbabwe; Medical School, Avondale.; A study on sexual behaviour and knowledge of HIV risk was undertaken amongst 511 male students in Zimbabwe . The study was conducted amongst pupils aged 11 to 19 years drawn from urban and rural secondary schools using a self-administered questionnaire. Thirty seven pc of the stud
[Correlation between bronchoalveolar lavage fluid angiotensin converting enzyme levels and T cell subsets in patients with sarcoidosis]: Chung Hua Chieh Ho Ho Hu Hsi Tsa Chih. 1994 Aug;17(4):235-7, 255-6. Unique Identifier : AIDSLINE MED/95136404; Li ZH; Li YL; Hou XM; Respiratory Diseases Institute China Medical University,; Shenyang.; BALF ACE levels were assayed in patients with sarcoidosis, and their correlation with lymphocyte percentage and TH/Ts ratio in BALF were analysed. The results showed a positive correlation (r = 0.4453, P
Sulfadiazine/N4-acetylsulfadiazine crystalluria in a patient with the acquired immune deficiency syndrome (AIDS) [letter]: Clin Chim Acta. 1994 Oct 31;230(2):221-4. Unique Identifier : AIDSLINE MED/95136492; Potter JL; Kofron WG; Department of Pathology, Children's Hospital Medical Center of; Akron, OH 44308.
Immunologic disturbances and levels of parathyroid hormone in uremic patients in replacement dialysis therapy.: Clin Nephrol. 1994 Oct;42(4):246-50. Unique Identifier : AIDSLINE MED/95136540; Angelini D; Carlini A; Mazzotta L; Mei E; Grassi R; Giusti R; Neri M; Fiorini I; Antonelli A; Department of Nephrology, Hospital of Lucca, Italy.; We studied the changes in cellular immunity in patients in replacement dialysis therapy (RDT) and examined the relationship between T-lymphocyte function and plasma levels of parathyroid hormone (PTH). In a preliminary study we found that increased plasma levels of PTH were associated with a decrease of T-lymphocytes
HIV risk factors for persons with serious mental illness.: Community Ment Health J. 1994 Dec;30(6):551-63. Unique Identifier : AIDSLINE MED/95136667; Knox MD; Boaz TL; Friedrich MA; Dow MG; Department of Community Mental Health, University of South; Florida's Florida Mental Health Institute, Tampa 33612-3899.; HIV risk factors were assessed among 120 persons in treatment for serious mental illness. Although subjects had good general knowledge regarding HIV, many engaged in high risk behaviors. Condom use was infrequent among those who had multiple sexual partners, and sharing needles was common for those who used i.v. drugs
Identifying the mental health needs of children living in families with AIDS or HIV infection.: Community Ment Health J. 1994 Dec;30(6):581-93. Unique Identifier : AIDSLINE MED/95136669; Roth J; Siegel R; Black S; Department of Child Psychiatry, St. Luke's/Roosevelt Hospital; Center, New York, New York.; The present article highlights the mental health needs of children living with loved ones who have AIDS or HIV infection. In addition the article describes an intervention program which is being developed to meet the needs of the children and their families. Children who live in families affected by AIDS and HIV infec
Review of the morphological variations in cutaneous cryptococcosis with a new case resembling varicella.: Cutis. 1994 Nov;54(5):343-7. Unique Identifier : AIDSLINE MED/95136691; Yantsos VA; Carney J; Greer DL; Department of Pathology, Tulane University School of Medicine,; New Orleans, Louisiana.; A 26-year-old black man with acquired immune deficiency syndrome and disseminated cryptococcosis presented with multiple small white vesiculopustular skin lesions on the face, trunk, and upper extremities mimicking varicella. To our knowledge, this is a novel presentation of cutaneous cryptococcal infection. A review
[Serum level of soluble interleukin-2 receptor and T-lymphocyte subpopulations in normal pregnancy]: Chung Hua Fu Chan Ko Tsa Chih. 1994 Sep;29(9):518-20, 572. Unique Identifier : AIDSLINE MED/95136754; Liu CL; Xu HY; Liu Y; Affiliated Hospital of Xuzhou Medical College, Jiangsu.; Serum soluble interleukin-2 receptor (sIL-2R) levels and T lymphocyte subpopulations were measured in 87 cases of normal pregnancy and 109 normal non-pregnant women as control group. It was found that sIL-2R level and CD8 T subpopulation increased as compared with control group (214,600 +/- 70,400 U/L vs 162,100 +/- 8
Pharmacokinetics of HIV protease inhibitor DMP 323 in rats and dogs.: Drug Metab Dispos. 1994 Sep-Oct;22(5):709-12. Unique Identifier : AIDSLINE MED/95136855; Grubb MF; Wong YN; Burcham DL; Saxton PL; Quon CY; Huang SM; Drug Metabolism and Pharmacokinetics Section, DuPont Merck; Pharmaceutical Company.; DMP 323 is a symmetrically substituted cyclic urea compound with demonstrated activity against human immunodeficiency virus (HIV) in vitro. DMP 323 has been measured in rat and dog plasma via liquid-liquid extraction and HPLC. The limit of quantitation is 10 ng/ml using 0.5 ml plasma. Following an intravenous dose of
[Pulmonary mucormycosis in an HIV-infected patient]: Dtsch Med Wochenschr. 1995 Jan 27;120(4):94-8. Unique Identifier : AIDSLINE MED/95136878; Harloff KJ; Stoehr A; Wasmuth R; Plettenberg A; Harten J; Medizinische Abteilung, Allgemeines Krankenhaus St. Georg,; Hamburg.; A 51-year-old man, known to have chronic-aggressive hepatitis B, HIV infection and exertional dyspnoea, was hospitalized because of acute physical deterioration, cough with whitish exudate and dyspnoea at rest. Despite a CD4/CD8 ratio of 0.16 no prophylactic measures against Pneumocystis carinii had been taken. On exa
Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis.: Dev Neurosci. 1993;15(6):417-22. Unique Identifier : AIDSLINE MED/95136893; Gelbard HA; Dzenko KA; DiLoreto D; del Cerro C; del Cerro M; Epstein LG; Department of Neurology, University of Rochester Medical Center,; N.Y. 14642.; Human immunodeficiency virus type 1 (HIV) infection of the central nervous system is characterized by neuronal loss in discrete areas of the central nervous system. We have previously demonstrated that HIV-infected monocytes in culture with astroglial cells produce high levels (> or = 200 pg/ml) of the cytokine tumor
In vivo model of HIV infection of the human brain.: Dev Neurosci. 1993;15(6):423-32. Unique Identifier : AIDSLINE MED/95136894; Achim CL; Miners DK; Burrola PG; Martin FC; Wiley CA; University of Pittsburgh Medical Center, Division of; Neuropathology, Pa.; Approximately one quarter of the AIDS patients have severe HIV encephalitis with diffuse neuronal damage that may be mediated by immune factors secreted by CNS macrophages. Based on an in vitro brain microsphere model, we developed an in vivo system in which human embryonic brain tissue survives for several months in
Clinical and immunological markers in Kenyan pulmonary tuberculosis patients with and without HIV-1.: East Afr Med J. 1994 Jun;71(6):373-5. Unique Identifier : AIDSLINE MED/95136904; Kivihya-Ndugga LE; Ochola JJ; Otieno G; Muthami LN; Gathua S; Diseases Research Unit, Kenya Medical Research Institute,; Nairobi.; Amongst newly diagnosed pulmonary tuberculosis patients, 44% were co-infected with human immunodeficiency virus (HIV). Pulmonary tuberculosis patients with HIV-1 presented more frequently with lymphadenopathy and diarrhoea than those without HIV-1. Peripheral blood CD4+ counts were significantly lower in patients with
Cryptosporidiosis among medical patients with the acquired immunodeficiency syndrome in Tikur Anbessa Teaching Hospital, Ethiopia.: East Afr Med J. 1994 Jun;71(6):376-8. Unique Identifier : AIDSLINE MED/95136905; Mengesha B; Department of Internal Medicine, Faculty of Medicine, Addis Ababa; University, Ethiopia.; Fresh stool specimens, collected at random from 63 medical in-patients with acquired immunodeficiency syndrome (AIDS), were studied prospectively for Cryptosporidium oocyst. The diagnosis of AIDS was made according to the clinical case definition of the Bangui criteria. These patients presented with profuse watery dia
Gut parasites in HIV-seropositive Zambian adults with diarrhoea.: East Afr Med J. 1994 Jun;71(6):379-83. Unique Identifier : AIDSLINE MED/95136906; Khumalo-Ngwenya B; Luo NP; Chintu C; Sunkutu R; Sakala-Kazembe F; Baboo KS; Mathewson J; Zumla A; Department of Parasitology, School of Medicine, University; Teaching, Hospital, Lusaka, Zambia.; We undertook a nine month study to define the frequency of parasitic infections in adults with diarrhoea presenting at the medical filter clinic and the Dermatovenereology clinic of the University Teaching Hospital in Lusaka, Zambia . A total of 287 patients with diarrhoea were enro
Clinical analysis of mortality in hospitalized Zambian children with sickle cell anaemia.: East Afr Med J. 1994 Jun;71(6):388-91. Unique Identifier : AIDSLINE MED/95136908; Athale UH; Chintu C; Department of Paediatrics Child Health, School of Medicine,; University of Zambia, Lusaka.; The hospital records of 62 Zambian children with sickle cell anaemia (SCA) who died during a 3 year period (January 1987 to December 1989) at the Paediatric Wing of the University Teaching Hospital, Lusaka, Zambia, were reviewed retrospectively. The SCA patients accounted for 2.92 percent of the total admissions and t
Novel mechanism and factor for regulation by HIV-1 Tat.: EMBO J. 1995 Jan 16;14(2):321-8. Unique Identifier : AIDSLINE MED/95137012; Zhou Q; Sharp PA; Center for Cancer Research, Massachusetts Institute of; Technology, Cambridge 02139.; Tat regulation of human immunodeficiency virus (HIV) transcription is unique because of its specificity for an RNA target, TAR, and its ability to increase the efficiency of elongation by polymerase. A reconstituted reaction that is Tat-specific and TAR-dependent for activation of HIV transcription has been used to id
Cleavage of recombinant and cell derived human immunodeficiency virus 1 (HIV-1) Nef protein by HIV-1 protease.: FEBS Lett. 1995 Jan 9;357(3):275-8. Unique Identifier : AIDSLINE MED/95137104; Gaedigk-Nitschko K; Schon A; Wachinger G; Erfle V; Kohleisen B; GSF-Forschungszentrum fur Umwelt und Gesundheit, Institut fur; Molekulare Virologie, Oberschleissheim, Germany.; Recombinant purified Nef protein of HIV-1, as well as Nef protein derived from extracts of permanently HIV-1 infected glioblastoma cells and monocytes, are specifically cleaved by the HIV-1 protease. Nef cleavage products in cellular extracts treated with protease showed identical molecular weights as those obtained b
Secondary structure in solution of two anti-HIV-1 hammerhead ribozymes as investigated by two-dimensional 1H 500 MHz NMR spectroscopy in water.: FEBS Lett. 1995 Jan 9;357(3):317-23. Unique Identifier : AIDSLINE MED/95137114; Sarma RH; Sarma MH; Rein R; Shibata M; Setlik RS; Ornstein RL; Kazim AL; Cairo A; Tomasi TB; Institute of Biomolecular Stereodynamics, State University of New; York at Albany 12222.; Two hammerhead chimeric RNA/DNA ribozymes (HRz) were synthesized in pure form. Both were 30 nucleotides long, and the sequences were such that they could be targeted to cleave the HIV-1 gag RNA. Named HRz-W and HRz-M, the former had its invariable core region conserved, the latter had a uridine in the invariable regio
[Inspection of surgical rubber gloves used during dental procedures]: Fogorv Sz. 1994 Dec;87(12):363-7. Unique Identifier : AIDSLINE MED/95137116; Berta I; Csakanyi R; Pecsi Orvostudomanyi Egyetem, Fogaszati es Szajsebeszeti; Klinika.; The resistance and durability of operating rubber gloves (PALMA) during different types of dental treatment were investigated. Six percent of the rubber gloves were found to be defective. One pair of gloves could be used 2.15 times on average. The vulnerability of the gloves increased after repeated sterilizations. Th
The Medical Center of Delaware. The HIV community program [letter]: Del Med J. 1994 Dec;66(12):693-4. Unique Identifier : AIDSLINE MED/95137158; Holloway WJ
The role of TNF-alpha in T-cell-mediated inflammation depends on the Th1/Th2 cytokine balance.: Immunology. 1994 Aug;82(4):591-5. Unique Identifier : AIDSLINE MED/95137621; Hernandez-Pando R; Rook GA; Department of Pathology, Instituto Nacional de la Nutricion; Salvador Zubiran, Mexico DF.; The role of tumour necrosis factor-alpha (TNF-alpha) in tuberculosis is paradoxical because although there is much evidence for a protective role, there is also evidence that it plays a part in the tissue damage that characterizes human disease. We have shown previously that TNF-alpha frequently induces necrosis when
Infiltration of CD4+ CD8+ T cells, and expression of ICAM-1, Ia antigens, IL-1 alpha and TNF-alpha in the skin lesion of BALB/c mice undergoing repeated infestations with nymphal Ixodes ricinus ticks.: Immunology. 1994 Aug;82(4):596-602. Unique Identifier : AIDSLINE MED/95137622; Mbow ML; Rutti B; Brossard M; Institute of Zoology, University of Neuchatel, Switzerland.; The skin cellular immune response of BALB/c mice was examined during three successive infestations with nymphal Ixodes ricinus ticks. An immunohistochemical analysis of skin cryostat sections 72 hr post-tick attachment revealed that CD4+ T cells outnumbered CD8+ T cells in all infestations. The CD4+:CD8+ T-cell ratio
Phenotypic and functional heterogeneity of murine intestinal intraepithelial lymphocytes defined by cell density: implications for route of differentiation and responsiveness to proliferation induction.: Immunology. 1994 Aug;82(4):611-6. Unique Identifier : AIDSLINE MED/95137624; Hamad M; Klein JR; Department of Biological Science, University of Tulsa, Oklahoma; 74104.; The phenotype and function of murine intestinal intraepithelial lymphocytes (IEL) was studied in a Percoll-fractionated preparation that consisted of low-density cells which migrated to the 40-50% Percoll interface (IEL-40), medium-density cells which migrated to the 50-55% interface (IEL-50), and high-density cells w
Locomotor phenotypes of unstimulated CD45RAhigh and CD45ROhigh CD4+ and CD8+ lymphocytes in three-dimensional collagen lattices.: Immunology. 1994 Aug;82(4):617-24. Unique Identifier : AIDSLINE MED/95137625; Friedl P; Noble PB; Shields ED; Zanker KS; Faculty of Dentistry, McGill University, Montreal, Quebec,; Canada.; The spontaneous locomotion of immunomagnetically isolated resting CD4+ and CD8+ lymphocytes in three-dimensional collagen gels was recorded by time-lapse videomicroscopy. Two-dimensional projections of the paths of randomly selected individual cells were digitized, plotted and quantitatively analysed. Among five diffe
CD4+ T cells are essential in overcoming experimental murine measles encephalitis.: Immunology. 1994 Oct;83(2):184-9. Unique Identifier : AIDSLINE MED/95137635; Finke D; Liebert UG; Institut fur Virologie und Immunbiologie, Universitat; Wurzburg, Germany.; Clinical observations and experimental animal models have stressed the importance of the cellular immune response in the recovery from measles virus infection. However, the relative contribution of different T-cell subsets to viral elimination is controversial. The aim of the present study was to define the components
Antibodies to human and non-human primate cellular and culture medium components in macaques vaccinated with the simian immunodeficiency virus.: Immunology. 1994 Oct;83(2):213-20. Unique Identifier : AIDSLINE MED/95137639; Bergmeier LA; Walker J; Tao L; Cranage M; Lehner T; Division of Immunology, United Medical and Dental School, Guy's; Hospital, London, UK.; Inactivated simian immunodeficiency virus (SIV) grown in a human T-cell line induces protection from infection by the virus in macaques. However, observations that immunization with uninfected human T cells or with SIV-1 prepared in human T cells can also induce protection, has raised the possibility that protective a
IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.: Immunology. 1994 Nov;83(3):329-32. Unique Identifier : AIDSLINE MED/95137658; Cohen SB; Katsikis PD; Feldmann M; Londei M; Kennedy Institute of Rheumatology, Sunley Division, Hammersmith,; London.; Interleukin-10 (IL-10) has various immunomodulatory actions depending on the target cell type. Some of these effects have been shown to be owing to its ability to down-regulate surface expression of markers, for example HLA-DR on macrophages and CD25 ( IL-2 receptor alp
Protection against tuberculosis by passive transfer with T-cell clones recognizing mycobacterial heat-shock protein 65.: Immunology. 1994 Nov;83(3):341-6. Unique Identifier : AIDSLINE MED/95137660; Silva CL; Silva MF; Pietro RC; Lowrie DB; Department of Parasitology, Microbiology and Immunology, School; of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil.; We have previously shown that mice vaccinated by injection with J774 macrophage-like tumour cells that expressed Mycobacterium leprae heat-shock protein (hsp) 65 as a transgene had acquired a remarkably high degree of protection against subsequent challenge with virulent M. tuberculosis. We show here that antigen-spec
A Th1 cell line (3E9.1) from resistant A/J mice inhibits induction of macrophage procoagulant activity in vitro and protects against MHV-3 mortality in vivo.: Immunology. 1994 Nov;83(3):353-61. Unique Identifier : AIDSLINE MED/95137662; Chung S; Gorczynski R; Cruz B; Fingerote R; Skamene E; Perlman S; Leibowitz J; Fung L; Flowers M; Levy G; University of Toronto, Canada.; Induction of immune coagulants has been implicated in the pathogenesis of murine hepatitis virus strain 3 (MHV-3)-induced fulminant hepatic necrosis. Previous work from our laboratory has shown that the induction of procoagulant activity (PCA) correlates with the resistance/susceptibility to disease in inbred and reco
Anti-IL-4 monoclonal antibody and IFN-gamma administration retards development of immune dysfunction and cytokine dysregulation during murine AIDS.: Immunology. 1994 Nov;83(3):384-9. Unique Identifier : AIDSLINE MED/95137666; Wang Y; Ardestani SK; Liang B; Beckham C; Watson RR; Department of Family and Community Medicine, University of; Arizona, Tucson 85724.; This study was designed to determine if administration of anti-interleukin-4 (IL-4) monoclonal antibody (mAb), interferon-gamma (IFN-gamma) and their combination after LP-BM5 retrovirus infection of female C57BL/6 mice would prevent retrovirus-induction of immunosuppression and cytokine dysregulation. Splenic natural
Role of IL-2 and IL-4 in exacerbations of murine antigen-induced arthritis.: Immunology. 1994 Nov;83(3):390-6. Unique Identifier : AIDSLINE MED/95137667; Jacobs MJ; van den Hoek AE; van Lent PL; van de Loo FA; van de Putte LB; van den Berg WB; Department of Rheumatology, University Hospital Nijmegen, The; Netherlands.; In this study the roles of different T-cell subsets, and produced cytokines, were investigated in an animal model for acute exacerbations. Flare-up reactions are inducible in the chronic phase of a smouldering antigen-induced inflammation by injection of a small amount of an antigen into a hyper-reactive knee joint. I
Targeting of pancreatic islets of severe combined immunodeficient mice by passive transfer of allogeneic spleen cells from non-obese diabetic mice.: Immunol Cell Biol. 1994 Oct;72(5):390-7. Unique Identifier : AIDSLINE MED/95137690; Reddy S; Liu W; Elliott RB; Department of Paediatrics, University of Auckland School of; Medicine, New Zealand.; The precise role of immune cells in beta cell killing and their manner of invasion of pancreatic islets in insulin-dependent diabetes mellitus (IDDM) are unclear. We have attempted to target pancreatic islets of severe-combined immunodeficient (SCID) mice with spleen cells from diabetic and non-diabetic female non-obe
An evaluation of drug injection behaviors and HIV infection. National AIDS Research Consortium.: Int J Addict. 1994 Oct;29(12):1499-518. Unique Identifier : AIDSLINE MED/95137726; Zhuo Z; Williams M; Bell D; Affiliated Systems Corporation, Houston, Texas 77027-6022.; This paper investigates domains of drug injection behavior and the association of derived factors to HIV serostatus. Two sets of data were randomly selected and matched from a national data set of over 40,000 drug injectors. One set was HIV seropositive and the other HIV seronegative heterosexual injectors. Samples we
Promiscuous and specific binding of HIV peptides to HLA-DR1 and DR103. Impact on T-cell repertoire of nonimmunized individuals.: Hum Immunol. 1994 Sep;41(1):56-60. Unique Identifier : AIDSLINE MED/95137782; Praud C; Jurcevic S; L'Faqihi FE; Guiraud M; de Preval C; Thomsen M; INSERM U395, Toulouse, France.; The binding of immunogenic peptides to DR molecules is influenced by residues that point into the peptide-binding groove. The T-cell response toward a peptide complexed to an MHC molecule depends on the presence of a sufficient number of T cells reactive with peptide-MHC complex on the surface of APCs. From 96 overlap
Acquired immunodeficiency syndrome and health care professionals.: J Assoc Physicians India. 1994 Jan;42(1):22-3. Unique Identifier : AIDSLINE MED/95137967; Menon V; Bharucha K; Dept of Obst & Gynaec., Medical College & Sassoon General; Hospital, Pune.; As health care professionals, we face a grave risk of acquiring HIV infection in the course of our work. But how many of us really know the precautions to be applied in the hospital set up in dealing with HIV infected patients? A knowledge, attitude and practice (KAP) study was conducted in Pune hospitals to assess th
PCP in a patient of AIDS in India [letter; comment]: J Assoc Physicians India. 1994 Jan;42(1):87. Unique Identifier : AIDSLINE MED/95137996; Bhatia RS; Sibia SS
Viral encephalitis: addendum [letter; comment]: J Assoc Physicians India. 1994 Jan;42(1):89-90. Unique Identifier : AIDSLINE MED/95138001; Gohel DR; Oza JJ; Bhil VJ
Local and global structural properties of the HIV-MN V3 loop.: J Biol Chem. 1995 Feb 3;270(5):2224-32. Unique Identifier : AIDSLINE MED/95138191; Catasti P; Fontenot JD; Bradbury EM; Gupta G; Theoretical Biology and Biophysics Group, Los Alamos National; Laboratory, New Mexico 87545.; Studies of the feasibility of a subunit vaccine to protect against human immunodeficiency virus (HIV) infection have principally focused on the third variable (V3) loop. The principal neutralizing determinant (PND) of HIV-1 is located inside the V3 loop of the surface envelope glycoprotein, gp120. However, progress to
A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro.: J Biol Chem. 1995 Feb 3;270(5):2274-83. Unique Identifier : AIDSLINE MED/95138199; Parada CA; Yoon JB; Roeder RG; Laboratory of Biochemistry and Molecular Biology, Rockefeller; University, New York, New York 10021.; The cellular factor, LBP-1, can repress HIV-1 transcription by preventing the binding of TFIID to the promoter. Here we have analyzed the effect of recombinant LBP-1 on HIV-1 transcription in vitro by using a pulse-chase assay. LBP-1 had no effect on initiation from a preformed preinitiation complex and elongation to
The global epidemic of human immunodeficiency virus infection: past reflections, future directions.: Holist Nurs Pract. 1995 Jan;9(2):18-29. Unique Identifier : AIDSLINE MED/95138218; McCann TV; The impact of the global epidemic of human immunodeficiency virus (HIV) infection in developed countries has been far reaching, but its impact in developing countries is much more devastating. The common underlying theme that helps explain HIV and acquired immunodeficiency syndrome (AIDS) is inequality. The resources
High false alarm rates on a vigilance task may indicate recreational drug use.: J Clin Exp Neuropsychol. 1994 Oct;16(5):713-22. Unique Identifier : AIDSLINE MED/95138234; Damos DL; Parker ES; Institute of Safety and Systems Management, University of; Southern California 90089-0021.; Neuropsychologists need more sensitive methods to detect and measure recreational drug use in both research and clinical settings. In a study comparing the sensitivity of information processing tasks and neuropsychological instruments to detect early HIV-related cognitive decrements, 18 of 129 subjects tested positive
Neuropsychological performance and CD4 levels in HIV-1 asymptomatic infection.: J Clin Exp Neuropsychol. 1994 Oct;16(5):777-83. Unique Identifier : AIDSLINE MED/95138241; Podraza AM; Bornstein RA; Whitacre CC; Para MF; Fass RJ; Rice RR Jr; Nasrallah HA; Maine Head Trauma Center Bangor.; The performance of 68 HIV-1 seropositive asymptomatic (HIV+) subjects stratified on CD4 levels were compared with 82 HIV-1 seronegative (HIV-) subjects on a battery of neuropsychological, mood state, and perceived health status measures. The neuropsychological test battery included measures of attention, reaction time
Costimulatory signals can selectively modulate cytokine production by subsets of CD4+ T cells.: J Immunol. 1995 Feb 15;154(4):1684-90. Unique Identifier : AIDSLINE MED/95138511; Shanafelt MC; Soderberg C; Allsup A; Adelman D; Peltz G; Lahesmaa R; Department of Leukocyte Biology, Syntex Research, Palo Alto, CA; 94303.; Analysis of experimental animal models and human clinical samples has indicated that the selective activation of CD4+ T cell subsets with distinct profiles of cytokine production plays an important role in the pathogenesis of human inflammatory and allergic diseases. The possibility that differential activation of cos
Superantigen-induced human CD4+ helper/killer T cell phenomenon. Selective induction of Th1 helper/killer T cells and application to tumor immunotherapy.: J Immunol. 1995 Feb 15;154(4):1777-85. Unique Identifier : AIDSLINE MED/95138521; Kuge S; Miura Y; Nakamura Y; Mitomi T; Habu S; Nishimura T; Department of Surgery, Tokai University School of Medicine,; Isehara, Japan.; Human CD4+ T cells activated with staphylococcal enterotoxin A (SEA) were fractionated by Percoll discontinuous density gradient centrifugation to enrich SEA-reactive CD4+ T cells. The SEA-reactive CD4+ T cells showed significant cytotoxicity, so-called superantigen-dependent cell-mediated cytotoxicity, against SEA-co
Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions.: J Immunol. 1995 Feb 15;154(4):1956-63. Unique Identifier : AIDSLINE MED/95138541; Ohmen JD; Hanifin JM; Nickoloff BJ; Rea TH; Wyzykowski R; Kim J; Jullien D; McHugh T; Nassif AS; Chan SC; et al; Division of Dermatology, University of California, School of; Medicine, Los Angeles 90024.; The skin lesions of patients with atopic dermatitis provide a model to study immunoregulation in human allergy. To determine the local cytokine pattern of cells present (both endogenous and recruited) at the site of disease, we extracted RNA from skin biopsy specimens from patients with atopic dermatitis, allergic con
T cell genetic background determines default T helper phenotype development in vitro.: J Exp Med. 1995 Feb 1;181(2):713-21. Unique Identifier : AIDSLINE MED/95138703; Hsieh CS; Macatonia SE; O'Garra A; Murphy KM; Department of Pathology, Washington University School of; Medicine, St. Louis, Missouri 63110.; A host s ability to resist certain pathogens such as Leishmania major can depend upon the phenotype of T helper (Th) subset that develops. Different murine genetic backgrounds are known to significantly alter the direction of Th subset development, although the cellular basis of this influence is poorly understood. To
Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris.: J Exp Med. 1995 Feb 1;181(2):769-74. Unique Identifier : AIDSLINE MED/95138709; Curry AJ; Else KJ; Jones F; Bancroft A; Grencis RK; Dunne DW; Department of Pathology, University of Cambridge, United Kingdom.; In murine models of Schistosoma mansoni infection, egg production is associated with a switch from T helper cell (Th)1- to Th2-type responses to both schistosome-specific and unrelated antigens. Polyparasitism is common in human populations within S. mansoni endemic areas. We have, therefore, examined whether coinfect
Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.: J Exp Med. 1995 Feb 1;181(2):775-9. Unique Identifier : AIDSLINE MED/95138710; van der Pouw Kraan TC; Boeije LC; Smeenk RJ; Wijdenes J; Aarden LA; Department of Autoimmune Diseases, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam.; During human immunodeficiency virus infection and allergic diseases, characterized by a dominant T helper (Th) 2 response, overproduction of prostaglandin E2 (PGE2) is observed. In this paper we studied the effect of PGE2 on interleukin (IL)-12 synthesis, because this cytokine has been described to be essential in ind
Cognitive event-related potentials and brain magnetic resonance imaging in HTLV-1 associated myelopathy (HAM).: J Neurol Sci. 1994 Oct;126(1):30-9. Unique Identifier : AIDSLINE MED/95138729; Fukushima T; Ikeda T; Uyama E; Uchino M; Okabe H; Ando M; First Department of Internal Medicine, Kumamoto University School; of Medicine, Japan.; Auditory and visual cognitive event-related potentials (ERPs) were investigated in 14 patients with HTLV-1 associated myelopathy (HAM) and in 36 normal controls. In the HAM patients, the latencies of P300 and N200 by the auditory tone method were significantly delayed, and N100 by the auditory click method was signifi
Intrathecal synthesis of interleukin-10 (IL-10) in viral and inflammatory diseases of the central nervous system.: J Neurol Sci. 1994 Oct;126(1):49-53. Unique Identifier : AIDSLINE MED/95138731; Gallo P; Sivieri S; Rinaldi L; Yan XB; Lolli F; De Rossi A; Tavolato B; Institute of Neurology, University of Padua School of Medicine,; Italy.; The intrathecal synthesis of interleukin 10 (IL-10) was investigated in 120 paired cerebrospinal fluid (CSF) and serum specimens from patients with various inflammatory and non-inflammatory diseases of the central nervous system (CNS). IL-10 was not demonstrated in the sera, but detectable levels were found in the CSF
Risk management and legal issues in home care: the utilization of nursing staff.: J Obstet Gynecol Neonatal Nurs. 1994 Oct;23(8):659-66. Unique Identifier : AIDSLINE MED/95138778; Brent NJ; A sound, integrated risk-management program in home health care can significantly reduce the potential for inclusion in lawsuits. Focusing on two clinical patient care situations (the pregnant woman receiving home uterine activity monitoring and the female patient with acquired immune deficiency syndrome), this articl
Programs for persons living with HIV disease [news]: J Okla State Med Assoc. 1994 Dec;87(12):561-2. Unique Identifier : AIDSLINE MED/95138798
Hemostatic disorders in feline immunodeficiency virus-seropositive cats.: J Vet Intern Med. 1994 Sep-Oct;8(5):355-62. Unique Identifier : AIDSLINE MED/95138904; Hart SW; Nolte I; Clinic of Small Animals, Hanover School of Veterinary Medicine,; Germany.; The hemostatic function of 40 feline immunodeficiency virus (FIV) seropositive and 8 FIV and feline leukemia virus (FeLV) seropositive cats was evaluated and compared with reference values from 30 clinically healthy cats. The FIV-positive cats were divided into 3 groups: group I included asymptomatic carriers; group I
HIV and psychoimmunology: evidence promising and forthcoming.: J R Soc Med. 1994 Nov;87(11):687-90. Unique Identifier : AIDSLINE MED/95138986; Miller D; Nott KH; Vedhara K; Department of Public Health, Medicine and Epidemiology,; University Hospital, Queen's Medical Centre, Nottingham, UK.
Anti-human immunodeficiency virus and anti-hepatitis-B virus activities and toxicities of the enantiomers of 2'-deoxy-3'-oxa-4'-thiocytidine and their 5-fluoro analogues in vitro.: J Med Chem. 1995 Jan 6;38(1):1-4. Unique Identifier : AIDSLINE MED/95139015; Mansour TS; Jin H; Wang W; Hooker EU; Ashman C; Cammack N; Salomon H; Belmonte AR; Wainberg MA; BioChem Therapeutic Inc., Laval, Quebec, Canada.
Relative binding free energies of peptide inhibitors of HIV-1 protease: the influence of the active site protonation state.: J Med Chem. 1995 Jan 6;38(1):42-8. Unique Identifier : AIDSLINE MED/95139034; Chen X; Tropsha A; Laboratory for Molecular Modeling, School of Pharmacy, University; of North Carolina, Chapel Hill 27599.; Hydrogen bonding plays an important role in the stabilization of complexes between HIV-1 protease (HIV-1 PR) and its inhibitors. The adequate treatment of the protease active site protonation state is important for accurate molecular simulations of the protonation state is important for accurate molecular simulations
[Protozoan and helminthic infection]: Nippon Rinsho. 1994 Dec;Suppl 6:179-82. Unique Identifier : AIDSLINE MED/95139249; Shibuya T; Department of Parasitology, Teikyo University School of Medicine.
[A case of pulmonary tuberculosis with HIV infection--review of 5 cases in Japan]: Kekkaku. 1994 Nov;69(11):693-8. Unique Identifier : AIDSLINE MED/95139535; Koyama R; Nakanishi F; Katoh S; Hokkaido Prefecture Sapporo Kitano Hospital, Japan.; Recently we encountered a case of pulmonary tuberculosis with HIV infection. The patient was 54-years old male. His chief complaints were anemia, emaciation and severe diarrhea. He was admitted to our hospital on September 18, 1992. He had been diagnosed in another clinic as having pulmonary tuberculosis before the ad
[Studies on therapeutic efficacy of a new anti-tuberculous drug, benzoxazinorifamycin, against murine experimental mycobacterial infections: attempt at various regimens and protocols]: Kekkaku. 1994 Nov;69(11):703-10. Unique Identifier : AIDSLINE MED/95139536; Tomioka H; Saito H; Department of Microbiology and Immunology, Shimane Medical; University, Izumo, Japan.; Because of the recent AIDS endemic, there is a worldwide increase in intractable mycobacterial infections including extrapulmonary tuberculosis due to multidrug-resistant M. tuberculosis and disseminated M. avium complex (MAC) infections. Therefore, development of new anti-tuberculous drugs having an excellent antimyc
[New drugs against tuberculosis and nontuberculous mycobacterial infections: a review]: Kekkaku. 1994 Nov;69(11):711-7. Unique Identifier : AIDSLINE MED/95139537; Amitani R; Kuze F; Department of Infection and Inflammation, Kyoto University,; Japan.; The number of cases with tuberculosis is again increasing in many countries, and recently several nosocomial outbreaks of multidrug-resistant tuberculosis have occurred in the United States . The number of patients with disseminated Mycobacterium avium complex (MAC) infections in AIDS p
[Analysis of host defense mechanism against mycobacterial infection and its application to therapy with biological response modifiers]: Kekkaku. 1994 Nov;69(11):719-23. Unique Identifier : AIDSLINE MED/95139538; Kawakami K; First Department of Internal Medicine, Faculty of Medicine,; University of the Ryukyus, Okinawa, Japan.; Recently, tuberculosis have been increasing among the immunocompromised patients. In patients with acquired immunodeficiency syndrome (AIDS), multi-drug resistant mycobacteria are often detected, which make the therapy difficult. In these patients, chemotherapy alone is often insufficient and some treatment to augment
[Therapeutic efficacy of macrolide in pulmonary nontuberculous mycobacteriosis]: Kekkaku. 1994 Nov;69(11):725-32. Unique Identifier : AIDSLINE MED/95139539; Tomono K; Second Department of Internal Medicine, Nagasaki University; School of Medicine, Japan.; Clarithromycin (CAM) is semi-synthetic macrolide antimicrobial agent, differing from erythromycin by an O-methyl substitution at position 6 of the 14-membered lactate ring. CAM is one of the very few antimicrobial agents that show activity against that Mycobacterium avium complex (MAC) in vivo, in vitro, and in AIDS p
A vision of professional nursing in 2020.: Kans Nurse. 1994 Oct;69(9):9. Unique Identifier : AIDSLINE MED/95139545; Jeffreys M
Danish haemophiliacs court case nears conclusion [news]: Lancet. 1995 Feb 4;345(8945):313. Unique Identifier : AIDSLINE MED/95139690; Skovmand K
HIV in England and Wales [news]: Lancet. 1995 Feb 4;345(8945):313. Unique Identifier : AIDSLINE MED/95139691; Thompson C
HIV/AIDS policies in sports [letter; comment]: Med Sci Sports Exerc. 1994 Nov;26(11):1420-1. Unique Identifier : AIDSLINE MED/95139800; McGrew C
Restrictions on HIV-infected health care workers [letter] [see comments]: Med J Aust. 1995 Jan 16;162(2):109. Unique Identifier : AIDSLINE MED/95139857; Vlahakis EG; Brieger GM; MacGibbon AL
Update: AIDS among women--United States, 1994 [published erratum appears in MMWR Morb Mortal Wkly Rep 1995 Feb 24;44(7):135]: MMWR Morb Mortal Wkly Rep. 1995 Feb 10;44(5):81-4. Unique Identifier : AIDSLINE MED/95139930; In 1993, human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) was the fourth leading cause of death among women aged 25-44 years in the United States (1); in addition, the incidence of AIDS is increasing more rapidly among women than men (2). Women with AIDS rep
Neurologic complications of AIDS: new concepts and treatments.: Mt Sinai J Med. 1994 Nov;61(6):484-91. Unique Identifier : AIDSLINE MED/95140035; Simpson DM; Tagliati M; Ramcharitar S; Department of Neurology, Mount Sinai School of Medicine, New; York, NY.; As patients progress from seroconversion to progressive HIV-1 disease, a variety of neurologic disorders may occur. These include diseases of the central and peripheral nervous systems as well as primary muscle disorders. This presentation focuses on clinical, laboratory, and pathologic features of these disorders. Th
Scabies [letter]: N Engl J Med. 1995 Mar 2;332(9):611; discussion 612. Unique Identifier : AIDSLINE MED/95140081; Parish LC
Scabies [letter]: N Engl J Med. 1995 Mar 2;332(9):611-2. Unique Identifier : AIDSLINE MED/95140082; Clotet B; Sirera G; Ferrandiz C
Immunological and virological markers determining progression to AIDS.: Neth J Med. 1994 Dec;45(6):238-43. Unique Identifier : AIDSLINE MED/95140113; Schellekens PT; Koot M; Roos MT; Tersmette M; Miedema F; Department of Clinical Viro-Immunology, Central Laboratory of The; Netherlands Red Cross Blood Transfusion Service, Amsterdam.; Infection with the human immunodeficiency virus (HIV-1) results in a severe immunodeficiency characterized by a depletion of CD4+ T-helper cells. Furthermore it is well documented that in asymptomatic persons the number of CD4+ cells is also a good predictor of progression to AIDS. However, persons with similar CD4+ c
Routine vaccination in HIV-infected patients: a review.: Neth J Med. 1994 Dec;45(6):244-9. Unique Identifier : AIDSLINE MED/95140114; Borleffs JC; Schneider MM; Department of Internal Medicine, Utrecht University Hospital,; Netherlands.; This paper reviews the literature from 1988 to November 1993 on the effectiveness of routine vaccination of HIV-infected adults. Data on the clinical benefit of vaccination in this particular group of patients are not available. In general, HIV-infected patients have suboptimal immunological responses to vaccines. In
Nephrotoxic serum nephritis in nude rats: the role of cell-mediated immunity.: Nephron. 1994;68(3):360-5. Unique Identifier : AIDSLINE MED/95140137; Kuroda T; Kawasaki K; Oite T; Arakawa M; Shimizu F; Department of Immunology, Niigata University School of Medicine,; Japan.; The role of T cell-mediated immunity in the early phase of nephrotoxic serum nephritis (NTN) was examined by transfer of pan T, CD8-positive, and CD4-positive cells. The disease was induced by transferring rabbit gamma-globulin (RGG)-sensitized T cells to nude (rnu/rnu) rats pretreated with a subnephritogenic dose (a
AIDS in the workplace: an OH dilemma.: Occup Health (Lond). 1994 Dec;46(12):413-5. Unique Identifier : AIDSLINE MED/95140339; Pratt RJ
Another year older....: Occup Health (Lond). 1994 Dec;46(12):416-7. Unique Identifier : AIDSLINE MED/95140340; Goldman L
Oral hairy leukoplakia in nonimmunosuppressed patients. Report of four cases.: Oral Surg Oral Med Oral Pathol. 1994 Nov;78(5):599-602. Unique Identifier : AIDSLINE MED/95140351; Lozada-Nur F; Robinson J; Regezi JA; Department of Stomatology, University of California San; Francisco.; Hairy leukoplakia was first described in association with HIV infection. Today hairy leukoplakia has come to represent a sign of immunosuppression and not just of HIV infection. Although molecular mechanisms have not been fully elucidated, Epstein-Barr virus appears to play a significant role in its etiopathogenesis.
Facial and perioral molluscum contagiosum in patients with HIV infection. A report of eight cases.: Oral Surg Oral Med Oral Pathol. 1994 Nov;78(5):621-6. Unique Identifier : AIDSLINE MED/95140355; Ficarra G; Cortes S; Rubino I; Romagnoli P; Institute of Stomatology, University of Florence, Italy.; Facial and perioral molluscum contagiosum is a common and often disfiguring condition in patients with HIV infection. The purpose of this study was to report on the clinical aspects of eight HIV-positive patients with facial molluscum contagiosum. Also we describe the histopathologic and electron microscopic findings
HIV-1 antibody positive hepatitis B surface antigen serum in a dental school patient population.: Oral Surg Oral Med Oral Pathol. 1994 Nov;78(5):670-2. Unique Identifier : AIDSLINE MED/95140363; Cade JE; Boozer CH; Lancaster DM; Lundgren G; Department of Oral Diagnosis/Medicine/Radiology, Louisiana State; University School of Dentistry, New Orleans.; Testing for human immunodeficiency virus antibody (anti-HIV-1) in patients positive for hepatitis B surface antigen has never been performed in a dental school patient population. In this population there was a 2.8% positive reactivity for HIV-1 antibodies in subjects who were also positive for hepatitis B surface ant
Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis.: Oncogene. 1995 Jan 19;10(2):269-77. Unique Identifier : AIDSLINE MED/95140416; Chlichlia K; Moldenhauer G; Daniel PT; Busslinger M; Gazzolo L; Schirrmacher V; Khazaie K; Department of Tumor Immunology, German Cancer Research Center,; Heidelberg.; The tax protein of Human T-cell leukemia virus type 1 (HTLV-1) is important for the transforming properties of this virus in vitro and is considered to be responsible for the early stages of leukemogenesis in infected hosts. To address the early consequences of HTLV-1 tax function, we have constructed fusion proteins
A CNS-enriched factor that binds to NF-kappa B and is required for interaction with HIV-1 tat.: Oncogene. 1995 Jan 19;10(2):395-400. Unique Identifier : AIDSLINE MED/95140429; Taylor JP; Pomerantz RJ; Oakes JW; Khalili K; Amini S; Jefferson Institute of Molecular Medicine, Department of; Biochemistry and Molecular Biology, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107.; The Human Immunodeficiency Virus type 1 (HIV-1) Tat protein is a potent activator of transcription directed by the long terminal repeat (LTR), an essential step in the life-cycle of HIV-1. While interaction of Tat with an RNA element encoded by downstream LTR sequences (termed TAR) is commonly considered essential to
Treating HIV in Pennsylvania.: Pa Med. 1994 Dec;97(12):32-3. Unique Identifier : AIDSLINE MED/95140467; Hoepfer M
Federal funds expand HIV/AIDS services [news]: Pa Med. 1994 Dec;97(12):49. Unique Identifier : AIDSLINE MED/95140472
Immunization with irradiated Plasmodium berghei sporozoites induces IL-2 and IFN gamma but not IL-4.: Parasite Immunol. 1994 Sep;16(9):479-91. Unique Identifier : AIDSLINE MED/95140494; White KL; Jarboe DL; Krzych U; Department of Biology, Catholic University of America,; Washington, DC 20064.; Protective immunity against Plasmodium induced by immunization with irradiated sporozoites (SPZ) depends on both humoral and cellular responses. Although circumsporozoite protein (CSP)-specific cytolytic T lymphocyte responses have been established as an effector system, other cell types are required for protection. W
Parasitic gastroenteritis.: Pediatr Ann. 1994 Oct;23(10):556-60. Unique Identifier : AIDSLINE MED/95140504; La Via WV; B1P6; Arroyo Grande Pediatrics, CA 93420.; Parasitic causes of diarrhea are common in pediatric patients and have important public health implications. Therefore, diagnosis should be pursued vigorously in the appropriate clinical setting. Giardia and Cryptosporidium infections are the most common causes of disease in the United Sta
Gastrointestinal disease in immunocompromised children.: Pediatr Ann. 1994 Oct;23(10):562-9. Unique Identifier : AIDSLINE MED/95140505; Deveikis A; Pediatric Infectious Diseases, Long Beach Memorial Medical; Center, CA 90801-1428.
Condom availability for youth. Committee on Adolescence, American Academy of Pediatrics.: Pediatrics. 1995 Feb;95(2):281-5. Unique Identifier : AIDSLINE MED/95140552
Perinatal human immunodeficiency virus testing. Provisional Committee on Pediatric AIDS, American Academy of Pediatrics.: Pediatrics. 1995 Feb;95(2):303-7. Unique Identifier : AIDSLINE MED/95140557
In vivo decay kinetic parameters of hammerhead ribozymes.: Nucleic Acids Res. 1994 Dec 25;22(25):5571-5. Unique Identifier : AIDSLINE MED/95140617; Sioud M; Opstad A; Zhao JQ; Levitz R; Benham C; Drlica K; Institute of Immunology and Rheumatology, Rikshospitalet, Oslo,; Norway.; Ribozymes offer a potentially important way to inactivate intracellular RNA from almost any gene whose nucleotide sequence is known. Recently, we found that hammerhead ribozymes directed against mRNA of tumour necrosis factor alpha (TNF alpha) and its derivatives, preferentially bind to a cellular protein(s). To bette
Cloning and characterization of a c-myc intron binding protein (MIBP1).: Nucleic Acids Res. 1994 Dec 25;22(25):5679-85. Unique Identifier : AIDSLINE GENBANK/D37951; Makino R; Akiyama K; Yasuda J; Mashiyama S; Honda S; Sekiya T; Hayashi K; Oncogene Division, National Cancer Center Reseach Institute,; Tokyo, Japan.; The cDNA for a c-myc intron 1 binding protein 1 (MIBP1) in the rat was isolated from lambda gt11 and lambda ZAPII cDNA libraries. Sequencing of the cDNA clones revealed a long ORF which encoded a putative protein of 2437 amino acid residues. This protein has two widely separated zinc finger regions, each of which carr
Making sense of the use of blood and blood products.: Nurs Times. 1995 Jan 4-11;91(1):25-7. Unique Identifier : AIDSLINE MED/95140654; Dodsworth H; The administration of blood in hospital is a common procedure, but many health-care professionals have unanswered questions about blood products such as platelets. This paper looks at some of the considerations involved in the collection and use of blood and blood products.
Nursing abroad. Health drive.: Nurs Times. 1995 Jan 4-11;91(1):36-7. Unique Identifier : AIDSLINE MED/95140659; Cassidy J
HIV/AIDS. Maintaining confidentiality when tracing contacts.: Nurs Times. 1995 Jan 11-17;91(2):25-6. Unique Identifier : AIDSLINE MED/95140672; Mackereth P; Harrison T; The extent to which a patient who has HIV can rely on information relating to his or her status remaining confidential has been the subject of furious debate within and outside the nursing profession. This paper explores the issues, with particular reference to partner notification.
HIV/AIDS. Counselling drug users.: Nurs Times. 1995 Jan 11-17;91(2):26-8. Unique Identifier : AIDSLINE MED/95140673; Winship G; This paper examines the uptake of the HIV test in a busy London drug dependency unit and looks at some of the specialist aspects of HIV counselling with drug users. HIV pre-test counselling is an important health education opportunity. The current guidelines for HIV pre-test counselling with drug users suggest that pr
Synthesis of some new heterobicyclic compounds containing spiro-1,2,4-triazine moiety as potential anti-HIV and anticancer agents.: Pharmazie. 1994 Nov;49(11):811-4. Unique Identifier : AIDSLINE MED/95140786; Abdel-Rahman RM; Seada M; Fawzy M; el-Baz I; Department of Chemistry, Faculty of Education, Ain-Shams; University, Roxy, Cairo, Egypt.; A number of heterobicyclic compounds such as 1,3,5-thiazine, thiazolidinone, pyrimidine, pyrimidinedione, imidazole, quinazolinone and 1,2,4-triazinone derivatives have been sythesized by reaction of 1,6-dihydro-3(2H)-thioxo-6-spiro-(9 - fluorene)-1,2,4-triazin-5(4H)-one (1) with sulphur/nitrogen compounds in neutral
Tuberculosis, HIV co-epidemic to multiply sevenfold in Asia [news]: Public Health Rep. 1995 Jan-Feb;110(1):108-9. Unique Identifier : AIDSLINE MED/95140858
Nearly $28 million for AIDS care programs [news]: Public Health Rep. 1995 Jan-Feb;110(1):109. Unique Identifier : AIDSLINE MED/95140859
Clients without health insurance at publicly funded HIV counseling and testing sites: implications for early intervention.: Public Health Rep. 1995 Jan-Feb;110(1):47-52. Unique Identifier : AIDSLINE MED/95140866; Valdiserri RO; Gerber AR; Dillon BA; Campbell CH Jr; Centers for Disease Control and Prevention, National Center for; Prevention Services, Atlanta, GA 30333.; The characteristics of clients reporting no health insurance were compared with those reporting any health insurance at publicly funded human immunodeficiency virus (HIV) counseling and testing sites in the United States during 1992. Thirty of 65 funded health departments collect data
Pregnant nurse refuses to care for AIDS patient: termination. Case in point: Armstrong v. Flowers Hosp., Inc. 33 F. 3d 1308--AL (1994).: Regan Rep Nurs Law. 1994 Nov;35(6):2. Unique Identifier : AIDSLINE MED/95140890; Tammelleo AD
Nurse treating AIDS patient sues: Discovery Rule. Case in point: Casarez v. NME hospitals, Inc. 883 S.W. 2d 360--TX (1994).: Regan Rep Nurs Law. 1994 Nov;35(6):4. Unique Identifier : AIDSLINE MED/95140892; Tammelleo AD
[Prevention of cross contamination, patient to anesthesia apparatus to patient, using filters]: Rev Esp Anestesiol Reanim. 1994 Nov-Dec;41(6):322-7. Unique Identifier : AIDSLINE MED/95140922; Cochs J; Casals P; Villalonga R; Vences A; Irujo J; Suarez M; Servicio de Anestesiologia y Reanimacion, Ciudad Sanitaria y; Universitaria de Bellvitge, L'Hospitalet de Llobregat, Barcelona.; Concern for cross infections from patient to patient via apparatus is particularly relevant today. There are several ways to prevent patient contamination through anesthetic devices. Although there is no clinical evidence for using one alternative over another and each hospital establishes its own hygienic protocols,
Comparative study of single and nested PCR for the detection of proviral HIV2 DNA.: Res Virol. 1994 Sep-Oct;145(5):337-42. Unique Identifier : AIDSLINE MED/95140936; Loussert-Ajaka I; Simon F; Farfara I; Houhou N; Couto-Fernandez J; Dazza MC; Brun-Vezinet F; Laboratoire de Virologie, Hopital Bichat-Claude Bernard, Paris.; We have tested seven pairs of primers for the detection of HIV2 DNA by single PCR in positive cultures from 21 infected patients. Four of these primer pairs were then used in a comparative study of single and nested PCR for the detection of HIV2 in fresh lymphocytes from 33 patients infected by the virus. HIV2 DNA was
[A case from practice (314). HIV-A2. Persistent hepatitis B infection. Status following syphilis. 3rd trimester pregnancy]: Schweiz Rundsch Med Prax. 1995 Jan 3;84(1):22-5. Unique Identifier : AIDSLINE MED/95140964; Beltinger J; Medizinische Universitats-Poliklinik, Departement fur Innere; Medizin, Kantonsspital, Basel.
[Primary pulmonary hypertension in a HIV positive patient]: Rev Pneumol Clin. 1994;50(2):68-70. Unique Identifier : AIDSLINE MED/95140977; Zraik N; Herry I; Setbon O; Cadranel J; Centre de Pneumologie et de Reanimation Respiratoire, Hopital; Tenon, Paris.; Apparently primary pulmonary hypertension is rarely described in patients infected with the human immunodeficiency virus (HIV). We observed a case in a HIV seropositive patient with no known risk factor for pulmonary vascular disease. The characteristics of this new association are described.
[Gene therapy and ethics]: Schweiz Med Wochenschr. 1995 Jan 10;125(1-2):34-41. Unique Identifier : AIDSLINE MED/95141036; Muller H; Rehmann-Sutter C; Abteilung Medizinische Genetik, Universitatskinderklinik, Basel.; Gene therapy represents a new strategy to treat human disorders. It was originally conceived as a cure for severe monogenetic disorders. Since its conception, the spectrum of possible application for gene therapy has been to include the treatment of acquired diseases, such as various forms of cancer and some viral inf
[On the significance and insignificance of knowledge]: Schweiz Med Wochenschr. 1995 Jan 10;125(1-2):6-10. Unique Identifier : AIDSLINE MED/95141040; Koch MG
Reexamining AIDS research priorities [see comments]: Science. 1995 Feb 3;267(5198):633-6. Unique Identifier : AIDSLINE MED/95141066; Paul WE; Office of AIDS Research, National Institutes of Health, Bethesda,; MD 20892.
Rheumatic diseases in African blacks.: Semin Arthritis Rheum. 1994 Oct;24(2):139-53. Unique Identifier : AIDSLINE MED/95141084; Adebajo A; Davis P; Rheumatology Research Unit, Adenbrookes Hospital, Cambridge,; England.; Contrary to previous belief, there is increasing evidence that a broad spectrum of rheumatic diseases do affect African blacks. Although properly conducted epidemiological studies have yet to be performed, reports of population surveys from a variety of sub-Saharan African countries indicate that diseases such as rheu
Judgement on AIDS confidentiality not controversial, says MASA [news]: S Afr Med J. 1993 Nov;83(11):xvii. Unique Identifier : AIDSLINE MED/95141139
Bacillary angiomatosis. The first case reported in South Africa.: S Afr Med J. 1993 Nov;83(11):855-6. Unique Identifier : AIDSLINE MED/95141151; Levy GR; Nayler S; Department of Medicine, University of the Witwatersrand,; Johannesburg.; A 28-year-old white man, positive for HIV, who was admitted to hospital for pneumonia, had for 2 months had several fluctuating cutaneous purple nodules on his legs and abdomen. Cultures of two lesions were negative, but light and electron microscopy showed organisms characteristic of
Clinical guidelines for HIV/AIDS sufferers [news]: S Afr Med J. 1994 Oct;84(10):16. Unique Identifier : AIDSLINE MED/95141171
Latest research development in HIV/AIDS [news]: S Afr Med J. 1994 Oct;84(10):17, 20. Unique Identifier : AIDSLINE MED/95141172
[Doctors uncomfortable about AIDS patients [news]: S Afr Med J. 1994 Oct;84(10):20-1. Unique Identifier : AIDSLINE MED/95141173
HIV testing and informed consent--ethical considerations [see comments]: S Afr Med J. 1994 Oct;84(10):669-74. Unique Identifier : AIDSLINE MED/95141185; McLean GR; Jenkins T; Department of Philosophy, University of the Witwatersrand,; Johannesburg.; One of the authors (T.J.) was invited by the AIDS Advisory Group to form a widely representative committee to recommend ethical guidelines concerning the extent to which HIV testing should receive informed consent. This paper presents and argues for the recommended guidelines. The question is considered with regard to
Inappropriate use of rapid HIV antibody tests [letter; comment]: S Afr Med J. 1994 Oct;84(10):696-7. Unique Identifier : AIDSLINE MED/95141193; Miller N; van Rooyen J; Buck R
HIV testing in the insurance industry [letter; comment]: S Afr Med J. 1994 Oct;84(10):697-8. Unique Identifier : AIDSLINE MED/95141194; van der Merwe JA
Prevalence of vaginitis, syphilis and HIV infection in women in the Orange Free State.: S Afr Med J. 1994 Sep;84(9):602-5. Unique Identifier : AIDSLINE MED/95141213; Cronje HS; Joubert G; Muir A; Chapman RD; Divall P; Bam RH; Department of Obstetrics and Gynaecology, University of the; Orange Free State, Bloemfontein.; OBJECTIVE. To determine the prevalence of vaginitis, syphilis and HIV infection in women in the Orange Free State. METHOD. By cluster sampling, 120 rural (farm) and 120 urban (local authority) clusters, each containing 4 women, were selected. Women aged 18-49 years who were included in the study had a cervical smear t
CD8+ activated T lymphocytes produce an in vitro skin graft-versus-host reaction in an organotypic skin culture model.: Transplantation. 1995 Jan 15;59(1):69-78. Unique Identifier : AIDSLINE MED/95141370; Jakic-Razumovic J; Sale GE; Beauchamp MD; Storb R; Sandmaier BM; Program in Transplantation Biology, Fred Hutchinson Cancer; Research Center, Seattle, WA 98104.; We adapted organotypic skin cultures to the dog as a model for skin graft-versus-host reaction (GVHR) to explore the relative roles of T cells and cytokines. To produce GVHR, activated lymphocytes from bulk mixed leukocyte cultures (bMLC) from 2 dog leukocyte antigen-unrelated dogs were injected into organotypic skin
Survival of MHC-deficient mouse heterotopic cardiac allografts.: Transplantation. 1995 Jan 27;59(2):187-91. Unique Identifier : AIDSLINE MED/95141380; Campos L; Naji A; Deli BC; Kern JH; Kim JI; Barker CF; Markmann JF; Department of Surgery, Hospital of the University of; Pennsylvania, Philadelphia 19104.; The immunologic mechanisms involved in the destruction of murine cardiac allografts were evaluated using MHC-deficient mice. Specifically, we examined the survival of immediately vascularized heterotopic adult cardiac grafts deficient in MHC class I, MHC class II, or both MHC class I and II antigens following transpla
Phenotypic analysis of donor cells infiltrating the small intestinal epithelium and spleen during graft-versus-host disease.: Transplantation. 1995 Jan 27;59(2):268-73. Unique Identifier : AIDSLINE MED/95141394; Schattenfroh NC; Hoffman RA; McCarthy SA; Simmons RL; Department of Surgery, University of Pittsburgh, Pennsylvania; 15261.; One of the principal target organs during graft-versus-host disease (GvHD) is the intestinal epithelium, although the reasons for the preferential involvement of particular organs in this disease are not known. This study analyzed the subset distribution of donor and host lymphocytes in the small intestinal epithelium
[HTLV infections (editorial)]: Ugeskr Laeger. 1994 Dec 19;156(51):7661. Unique Identifier : AIDSLINE MED/95141480; Skinhoj P
[Human T-lymphotrophic virus type I and II--diagnosis and clinical presentation]: Ugeskr Laeger. 1994 Dec 19;156(51):7663-7. Unique Identifier : AIDSLINE MED/95141481; Christiansen CB; Virologisk afdeling, Statens Seruminstitut, Kobenhavn.; Human T-lymphotropic virus type 1, HTLV-I, was the first human oncogenic retrovirus to be isolated in 1978. HTLV-I has previously been called Human T-cell leukaemia virus or Human T-cell lymphoma virus type I. HTLV-I infection is endemic in southwestern Japan , the Caribbean basin, a
[A good HIV-vaccine is not enough]: Ugeskr Laeger. 1994 Dec 19;156(51):7703-4. Unique Identifier : AIDSLINE MED/95141492; Hansen J; Nielsen JO
Broadly reactive HIV-2 and SIVmac specific antibody-dependent cellular cytotoxicity in immunized and infected cynomolgus monkeys.: Vaccine. 1994 Oct;12(13):1203-8. Unique Identifier : AIDSLINE MED/95141682; von Gegerfelt A; Nilsson C; Putkonen P; Broliden K; Department of Virology, Karolinska Institute, Stockholm, Sweden.; Antibody-dependent cellular cytotoxicity (ADCC) was analysed in groups of cynomolgus monkeys that had been immunized with either HIV-2 (strains SBL6669 or SBL-K135) or SIVmac. HIV-2- and SIVmac-infected monkeys were also studied for ADCC. Sequential serum samples were collected from the animals, which were followed fo
Effect of a lipopeptidic formulation on macrophage activation and peptide presentation to T cells.: Vaccine. 1994 Oct;12(13):1209-14. Unique Identifier : AIDSLINE MED/95141683; Rouaix F; Gras-Masse H; Mazingue C; Diesis E; Ridel PR; Estaquier J; Capron A; Tartar A; Auriault C; Centre d'Immunologie des Maladies Transmissibles et Allergiques,; Unite mixte INSERM U167-CNRS 624, Lille, France.; We studied a 45-69 lipopeptide obtained by N-terminal modification with a N epsilon-palmitoyl lysine residue of the 45-69 peptide derived from the nef protein of HIV. T cells from animals immunized intraperitoneally with 45-69 lipopeptide proliferated in vitro in the presence of 45-69 peptide while no response was obt
Measles seroprevalence and vaccine response in HIV-infected adults.: Vaccine. 1994 Oct;12(13):1222-4. Unique Identifier : AIDSLINE MED/95141685; Wallace MR; Hooper DG; Graves SJ; Malone JL; Department of Internal Medicine (HIV Division), Naval Medical; Center, San Diego.; Measles in HIV-infected patients can be a severe, even fatal, illness. The prevalence of measles seropositivity in HIV-infected adults and the durability of these antibody levels are uncertain. A prospective survey of 210 HIV-infected adults found that 95% of the adults had demonstrable antibodies using a standard ELI
[Family planning in Latin America: development, costs, and future]: Adv Contracept. 1994 Jul;10 Suppl 1:19-31. Unique Identifier : AIDSLINE MED/95141837; Sanhueza H; IPPF/New York, NY 10010-6089.
Human immunodeficiency virus and the nervous system: some aspects of the molecular pathology.: Afr J Med Med Sci. 1993 Jun;22(2):1-3. Unique Identifier : AIDSLINE MED/95141859; Osuntokun BO; Department of Medicine, University of Ibadan, Nigeria.
HIV seropositivity in Nigerians with lymphoproliferative malignancies.: Afr J Med Med Sci. 1993 Dec;22(4):73-6. Unique Identifier : AIDSLINE MED/95141906; Okpala IE; Shokunbi WA; Saliu I; Akinboye DO; Essien EM; Department of Haematology, University College Hospital, Ibadan,; Nigeria.; One hundred and four Nigerians with lymphoproliferative malignancies were tested for antibodies to human immunodeficiency virus types 1 and 2 (HIV-1 and 2). All the patients with high grade lymphomas in this series were seronegative for HIV-1 and 2. Only 1 of the 104 patients had antibody to HIV-1 and none had antibod
Otorhinolaryngological aspects of HIV infections: personal experience.: Allergol Immunopathol (Madr). 1994 Sep-Oct;22(5):192-6. Unique Identifier : AIDSLINE MED/95141991; Zambetti G; Luce M; Ciofalo A; Leonardi M; Filiaci F; Department of Otorhinolaryngology, C.L.O., Rome University, La; Sapienza.; The involvement of the ENT sphere in HIV infections is fairly common, but the relative manifestations, though not to be considered atypical, are not pathognomonic. The present study has been set up for the otoiatric assessment of a group of HIV patients and the correlation of ENT symptoms with the various stages of th
Immunologic evaluation of 24 month course of sublingual immunotherapy.: Allergol Immunopathol (Madr). 1994 Sep-Oct;22(5):209-16. Unique Identifier : AIDSLINE MED/95141994; Tari MG; Mancino M; Madonna F; Buzzoni L; Parmiani S; Servizio Autonomo di Allergologia E Fisiopatologia Respiratoria,; Arienzo, Caserta, Italy.; 58 patients under 12 years of age, positive to mites (Dermatophagoides pteronyssinus and D. farinae) according to prick, in vitro specific IgE and challenge tests, suffering from asthma and rhinitis, have been randomly assigned on a double blind basis to receive per os either a biologically standardized extract of mit
Common neurologic complications of HIV-1 infection and AIDS.: Am Fam Physician. 1995 Feb 1;51(2):387-98. Unique Identifier : AIDSLINE MED/95142007; Newton HB; Ohio State University Hospitals, Columbus.; Complications of human immunodeficiency virus type 1 infection and acquired immunodeficiency syndrome may involve any level of the central or peripheral nervous system. Acute encephalitis, aseptic meningitis and acute demyelinating polyneuropathy may occur early in the course of HIV infection, while
Pathology and pathophysiology of primary pulmonary hypertension.: Am J Cardiol. 1995 Jan 19;75(3):51A-54A. Unique Identifier : AIDSLINE MED/95142027; Rubin LJ; Department of Medicine, University of Maryland School of; Medicine, Baltimore.; Primary pulmonary hypertension (PPH) is at present little understood. It is characterized by extensive remodeling of the pulmonary vasculature, with consequent deleterious hypertrophic changes in the right ventricle. Median survival is 2.6 years, although this varies with the severity of right heart failure. Although
Sexual transmission of human T-lymphotropic virus type I among female prostitutes and among patients with sexually transmitted diseases in Fukuoka, Kyushu, Japan [see comments]: Am J Epidemiol. 1995 Feb 15;141(4):305-11. Unique Identifier : AIDSLINE MED/95142082; Nakashima K; Kashiwagi S; Kajiyama W; Hirata M; Hayashi J; Noguchi A; Urabe K; Minami K; Maeda Y; Department of General Medicine, Kyushu University Hospital,; Fukuoka, Japan.; The authors investigated the prevalence of antibody to human T-lymphotropic virus type I (anti-HTLV-I) in 409 female prostitutes, 446 patients with an episode of sexually transmitted diseases, and 17,345 control blood donors. All subjects were Japanese and all studies were done in Fukuoka, Kyushu, Japan, in 1989. The
Comparison of rates of intracellular metabolism of zidovudine in human and primate peripheral blood mononuclear cells.: Antimicrob Agents Chemother. 1994 Oct;38(10):2398-403. Unique Identifier : AIDSLINE MED/95142584; Qian M; Chandrasena G; Ho RJ; Unadkat JD; Department of Pharmaceutics, School of Pharmacy, University of; Washington, Seattle 98195.; 3 -Azido-3 -deoxythymidine ( AZT ) is a drug of choice for the treatment of AIDS. On the basis of pharmacokinetic data, the nonhuman primate Macaca nemestrina has been shown to be a suitable animal model for use in the study of the disposition of AZT. H
Resistance of human immunodeficiency virus type 1 to acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidines.: Antimicrob Agents Chemother. 1994 Oct;38(10):2409-14. Unique Identifier : AIDSLINE MED/95142586; Nguyen MH; Schinazi RF; Shi C; Goudgaon NM; McKenna PM; Mellors JW; Department of Medicine, University of Pittsburgh School of; Medicine, Pennsylvania.; Acyclic 6-phenylselenenyl- and 6-phenylthiopyrimidine derivatives are potent and specific inhibitors of human immunodeficiency virus type 1 (HIV-1). The development of in vitro resistance to two derivatives, 5-ethyl-1-(ethoxymethyl)-(6-phenylthio)-uracil (E-EPU), was evaluated by serial passage of HIV-1 in increasing
Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation.: Antimicrob Agents Chemother. 1994 Oct;38(10):2430-9. Unique Identifier : AIDSLINE MED/95142590; Babe LM; Craik CS; Department of Pharmaceutical Chemistry, University of California,; San Francisco 94143-0446.; A stable cell line encoding the sequences of all the human immunodeficiency virus type 1 proteins, with the exception of the gp160 envelope glycoprotein, was derived from transfection of monkey COS-7 cells. This cell line, referred to as CH-1, produces active viral protease that correctly processes its natural substra
Azole resistance in oropharyngeal Candida albicans strains isolated from patients infected with human immunodeficiency virus.: Antimicrob Agents Chemother. 1994 Oct;38(10):2495-7. Unique Identifier : AIDSLINE MED/95142605; He X; Tiballi RN; Zarins LT; Bradley SF; Sangeorzan JA; Kauffman CA; Department of Internal Medicine, University of Michigan Medical; School, Ann Arbor.; For 212 oropharyngeal isolates of Candida albicans, the fluconazole MICs for 50 and 90% of strains tested were 0.5 and 16 micrograms/ml, respectively, and those of itraconazole were 0.05 and 0.2 micrograms/ml, respectively. Of 16 isolates for which fluconazole MICs were > 64 micrograms/ml, itraconazole MICs for 14 wer
Competitive inhibition of HIV-1 protease by biphenyl carboxylic acids.: Arch Biochem Biophys. 1995 Jan 10;316(1):523-8. Unique Identifier : AIDSLINE MED/95142674; Tummino PJ; Ferguson D; Jacobs CM; Tait B; Hupe L; Lunney E; Hupe D; Department of Biochemistry, Parke-Davis Pharmaceutical Research,; Division of Warner-Lambert Company, Ann Arbor, Michigan 48105.; A novel series of nonpeptidic compounds that contain a biphenyl carboxylic acid group have been shown to inhibit HIV-1 protease. The active compounds, most of which are highly soluble, have IC50 values in the range of 3.4-74 microM. The structure-inhibitory activity relationship demonstrates the necessity of the biphe
Myristoylation cannot functionally replace the isoprenylation of Rab5.: Arch Biochem Biophys. 1995 Jan 10;316(1):529-34. Unique Identifier : AIDSLINE MED/95142675; Li G; Barbieri MA; Stahl PD; Department of Cell Biology & Physiology, Washington University; School of Medicine, St. Louis, Missouri 63110.; C-terminal isoprenylation is necessary for the small GTPase Rab5 to associate with early endosomes and to exert its regulatory function in endocytosis. In this study, we tested whether Rab5 could retain its membrane association and biological function if the isoprenylation were replaced by another type of lipid modifi
Increasing number of AIDS cases, mostly caused by HIV-1 infection, in Dakar (Senegal).: Ann Soc Belg Med Trop. 1994 Sep;74(3):253-5. Unique Identifier : AIDSLINE MED/95142718; Sow PS; Faye MA; Diop BM; Diouf G; Colebunders R; Coll-Seck AM; Infectious Diseases Department, Fann Hospital, Dakar, Senegal.
[The autopsy findings in 51 cases of AIDS with cardiovascular damage]: Arch Inst Cardiol Mex. 1994 Sep-Oct;64(5):485-90. Unique Identifier : AIDSLINE MED/95142759; Rosales Guzman I; Rosales L; Zghaib A; IMSS, Instituto Nacional de Cardiologia Igancio Chavez, INCICH,; Tlalpan, Mexico, D.F.; We describe the cardiovascular abnormalities found at autopsy in patients with AIDS and a description of the opportunistic infections in these cases studied between January 1988 and August 1993. There were 51 cases with such diagnosis. Pericardial effusion appeared in 9, pleural effusion in 7, myocarditis in 5, 7 with
Into the future: HIV therapy advances. Introduction.: AIDS. 1994 Sep;8 Suppl 3:S1-2. Unique Identifier : AIDSLINE MED/95142946; Carosi G; Institute of Infectious and Tropical Diseases, University of; Brescia, Italy.
Into the future: HIV therapy advances. Satellite symposium to the 4th European Conference on Clinical Aspects of Treatment of HIV Infection. 16 March 1994. Proceedings.: AIDS. 1994 Sep;8 Suppl 3:S1-33. Unique Identifier : AIDSLINE MED/95142947
HIV therapy advances. Pediatric antiretroviral choices.: AIDS. 1994 Sep;8 Suppl 3:S15-8. Unique Identifier : AIDSLINE MED/95142948; Spector SA; Department of Pediatrics, University of California, San Diego, La; Jolla 92093-0672.; BACKGROUND: Zidovudine is the initial treatment of choice in HIV-infected children. Zalcitabine or didanosine may be used in children who do not respond adequately or who are intolerant of zidovudine. Several studies of the latter agents are reviewed. MONOTHERAPY STUDIES: Zalcitabine at 0.005 or 0.01 mg/kg three times
Interferons in HIV and related diseases.: AIDS. 1994 Sep;8 Suppl 3:S19-23. Unique Identifier : AIDSLINE MED/95142949; Lane HC; National Institutes of Allergy and Infectious Diseases, Bethesda,; Maryland 20892.; BACKGROUND: Since interferon-alpha has a very broad spectrum of activity it has been investigated in several clinical settings in the HIV-infected population. KAPOSI S SARCOMA: The rate of response to interferon-alpha is low in patients with low CD4 cell counts, but response rates of over 45% have been achieved in pat
HIV therapy advances. Update on a proteinase inhibitor.: AIDS. 1994 Sep;8 Suppl 3:S25-9. Unique Identifier : AIDSLINE MED/95142950; Vella S; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; HIV PROTEINASE INHIBITORS: The HIV proteinase enzyme has been identified as a potential target for antiretroviral therapy, as inhibition of this enzyme leads to the generation of immature, non-infectious virions. There are several proteinase inhibitors in development; the first to enter clinical trials was saquinavir.
Treatment options in zidovudine intolerance or failure.: AIDS. 1994 Sep;8 Suppl 3:S3-7. Unique Identifier : AIDSLINE MED/95142951; Abrams DI; Terry Beirn Community Programs for Clinical Research on AIDS,; University of California, San Francisco.; AIM: To compare the efficacy and safety of didanosine and zalcitabine in patients who could not tolerate zidovudine or who had failed to respond adequately. PATIENTS AND METHODS: A multicentre, randomly allocated, open-label clinical trial was set up with 230 patients treated with didanosine and 237 treated with zalci
Future treatment strategies in HIV infection.: AIDS. 1994 Sep;8 Suppl 3:S31-3. Unique Identifier : AIDSLINE MED/95142952; Dormont J; Department of Internal Medicine, Antoine Beclere Hospital,; Clamart, France.; EFFECTIVENESS OF EARLY TREATMENT WITH ZIDOVUDINE: In terms of progression to AIDS-related complex, AIDS or death, clinical trials have not yet shown any long-term benefit for early compared with deferred treatment with zidovudine. The Concorde trial showed a short-term benefit, as did two of the AIDS Clinical Trials G
HIV therapy advances. Early antiretroviral therapy.: AIDS. 1994 Sep;8 Suppl 3:S9-14. Unique Identifier : AIDSLINE MED/95142953; Cooper DA; National Centre in HIV Epidemiology and Clinical Research,; Faculty of Medicine, University of New South Wales, St Vincent's; Hospital Medical Centre, Sydney, Australia.; AIM: To review evidence suggesting that antiretroviral therapy should be initiated at an early stage in HIV infection. METHOD: Review of published data. CONCLUSIONS: There are arguments both for and against early antiretroviral therapy. Although the reasons against are undoubtedly valid, evidence of greater efficacy,
Head and neck lymphomas associated with human immunodeficiency virus infection.: Arch Otolaryngol Head Neck Surg. 1995 Feb;121(2):210-8. Unique Identifier : AIDSLINE MED/95142968; Carbone A; Vaccher E; Barzan L; Gloghini A; Volpe R; De Re V; Boiocchi M; Monfardini S; Tirelli U; Division of Pathology, Istituto Nazionale di Ricovero e Cura a; Carattere Scientifico, Aviano.; OBJECTIVE: To focus on clinicopathologic data of non-Hodgkin s lymphomas (NHLs) of the head and neck area (with lymph nodal or extranodal localization) arising in patients with immunodeficiency virus (HIV) infection. PATIENTS: Among 73 evaluable patients for presenting symptoms, of a total of 82 with HIV-related NHLs
Effect of pH and nonphysiological salt concentrations on human immunodeficiency virus-1 protease dimerization.: Biochem Cell Biol. 1994 May-Jun;72(5-6):175-81. Unique Identifier : AIDSLINE MED/95142975; Tyagi SC; Simon SR; Carter CA; Department of Medicine, University of Missouri, Columbia 65212.; Human immunodeficiency virus-1 (HIV-1) protease is catalytically active as a dimer of identical subunits that associate through noncovalent interactions. To investigate the forces stabilizing HIV-1 protease in its active form, we have studied the effects of pH and salts on structure and function of the enzyme. Enzymat
Hybrid PCR sequencing: sequencing of PCR products using a universal primer.: Biotechniques. 1994 Nov;17(5):896-901. Unique Identifier : AIDSLINE MED/95143023; Berg ES; Olaisen B; Department of Virology, National Institute of Public Health,; Oslo, Norway.; We describe a general method for making template DNA for sequencing of PCR products. The procedure may be particularly useful for PCR products where minimal sequence information is known or as an alternative to primer walking when sequencing long PCR products. A cassette containing the hybridization site for the M13 s
Differential reactivities of antibodies to HIV and HTLV-I in sera of suspected AIDS and ARC patients.: West Afr J Med. 1994 Jul-Sep;13(3):150-1. Unique Identifier : AIDSLINE MED/95143176; Aidoo M; Nishiwaki O; Akari H; Brandful JA; Ampofo W; Hayami M; Ayisi NK; Noguchi Memorial Institute for Medical Research, University of; Ghana, Legon.; Sera collection from 255 clinically diagnosed AIDS and ARC patients were analyzed for antibodies to HIV and HTLV-I by Western blot and particle agglutination methods respectively. Antibodies to HIV were detected in 37.3% of the sera collected as compared to 5.5% for HTLV-I. Most (95%) of the HIV positive sera had dual
Comparative analysis of HIV-1 and HIV-2 indeterminate western blot patterns.: West Afr J Med. 1994 Jul-Sep;13(3):164-7. Unique Identifier : AIDSLINE MED/95143180; Ayisi NK; Aidoo M; Virology Unit, Noguchi Memorial Institute for Medical Research,; University of Ghana, Legon.; A comparison of HIV-1 and HIV-2 indeterminate Western blot patterns of Ghanaian sera collected between 1989 and 1990 was made. Antibodies to group specific antigen (GAG) gene products were most frequently detected both HIV-1 and HIV-2 indeterminate sera. HIV-2 GAG gene product p26 was shown to be a non-specific indica
Women, sex, and HIV [editorial; comment]: Epidemiology. 1994 Nov;5(6):565-7. Unique Identifier : AIDSLINE MED/95143316; Zierler S
The efficiency of male-to-female and female-to-male sexual transmission of the human immunodeficiency virus: a study of 730 stable couples. Italian Study Group on HIV Heterosexual Transmission [see comments]: Epidemiology. 1994 Nov;5(6):570-5. Unique Identifier : AIDSLINE MED/95143318; Nicolosi A; Correa Leite ML; Musicco M; Arici C; Gavazzeni G; Lazzarin A; Department of Epidemiology and Medical Informatics, National; Research Council, Milan, Italy.; To compare the efficiency of male-to-female and female-to-male sexual transmission of human immunodeficiency virus (HIV), we studied 524 female partners of HIV-infected men and 206 male partners of HIV-infected women in 16 Italian clinical centers. All of the partners had had a sexual relationship with the index case
HIV revisited: preventing the spread of blood-borne viruses among injecting drug users [editorial]: Aust J Public Health. 1994 Sep;18(3):239-41. Unique Identifier : AIDSLINE MED/95143329; Wodak A; Crofts N
Knowledge and practice of sexual safety in Melbourne gay men in the nineties.: Aust J Public Health. 1994 Sep;18(3):319-25. Unique Identifier : AIDSLINE MED/95143345; Ridge DT; Plummer DC; Minichiello V; School of Behavioural Health Sciences, La Trobe University,; Melbourne.; Despite the impact of education programs, the ability of gay men to sustain sexual safety still comes under public scrutiny. A self-administered questionnaire was distributed in 1990 to a convenience sample of 284 gay-identified Melbourne men recruited from gay groups, health clinics, gay pubs and nightclubs, sex-on-p
Longitudinal predictors of burnout in HIV/AIDS health professionals.: Aust J Public Health. 1994 Sep;18(3):334-6. Unique Identifier : AIDSLINE MED/95143348; Bennett L; Kelaher M; Department of Behavioural and Social Sciences in Nursing,; University of Sydney, NSW.; This study examined causes of burnout in doctors, nurses and social workers caring for patients in HIV/AIDS units. There were 84 participants at Time 1 (1990) and 134 at Time 2 (1991). The results focus on the longitudinal subsample of 32 who participated in the study at both times. Path analysis was used to explore r
Correlation of antiphospholipid antibodies and protein S deficiency with thrombosis in HIV-infected men.: Blood Coagul Fibrinolysis. 1994 Aug;5(4):455-62. Unique Identifier : AIDSLINE MED/95143382; Hassell KL; Kressin DC; Neumann A; Ellison R; Marlar RA; Department of Medicine, Denver VA Medical Center, CO 80220.; Antiphospholipid antibodies (aPL) and free protein S (PSF) deficiency have been associated with clinical thrombosis. Previous reports described a high prevalence of these abnormalities in HIV-infected individuals, but suggested there was little associated clinical thrombosis. A cohort of 74 HIV-infected men were studi
Empiric antituberculosis treatment: benefits for earlier diagnosis and treatment of tuberculosis.: Tuber Lung Dis. 1994 Oct;75(5):334-40. Unique Identifier : AIDSLINE MED/95143518; Anglaret X; Saba J; Perronne C; Lacassin F; Longuet P; Leport C; Vilde JL; Service des Maladies Infectieuses et Tropicales, Hopital; Bichat-Claude Bernard, Paris, France.; SETTING: Tuberculosis may be diagnosed too late, especially in HIV-infected patients, with consequences on bacillus transmission and survival. Empiric antibuberculosis treatment (EATT) may be started before diagnosis of tuberculosis is confirmed. As rifampicin is a broad spectrum antibiotic, EATT including rifampicin
Quantitation of mycobacteria in blood specimens from patients with AIDS.: Tuber Lung Dis. 1994 Oct;75(5):386-90. Unique Identifier : AIDSLINE MED/95143527; Sanchez T; Vanderkolk J; Seay S; Heifets L; National Jewish Center for Immunology and Respiratory Medicine,; Denver, Colorado 80206.; OBJECTIVE: To determine the effect of a delay in processing blood specimens, that may occur by mailing them to a specialized laboratory, on the quantitation of the number of mycobacteria. DESIGN: Simulated blood specimens in sodium polyanetholium sulfonate (SPS)-containing vacutainers were spiked with Mycobacterium av
Tuberculosis as a cause of false-positive results in HIV screening EIA tests [letter]: Tuber Lung Dis. 1994 Oct;75(5):394-5. Unique Identifier : AIDSLINE MED/95143529; Werneck-Barroso E; Kritski AL; Vieira MA; Carvalho CE; Carvalho AC; Ferraz CM; Ferreira JA
Tuberculosis is the main pulmonary complication of AIDS in Tunisia [letter]: Tuber Lung Dis. 1994 Oct;75(5):397-8. Unique Identifier : AIDSLINE MED/95143532; Beji M; Louzir B; Tiouiri H; Khrouf M; Zribi A; Daghfous J
Worsening of liver function with fluconazole and review of azole antifungal hepatotoxicity.: Ann Pharmacother. 1994 Oct;28(10):1177-81. Unique Identifier : AIDSLINE MED/95143711; Gearhart MO; Department of Pharmacy, Good Samaritan Hospital, Dayton, OH; 45406.; OBJECTIVE: To report a case of fluconazole worsening of liver dysfunction. CASE SUMMARY: A patient with hepatitis experienced worsening of her liver function when treated with fluconazole for a Candida infection in her urine. Elevations in aspartate aminotransferase, alanine aminotransferase, and total bilirubin conce
Public health care policies for drug addicts in Amsterdam.: Acta Paediatr Suppl. 1994 Nov;404:72-4. Unique Identifier : AIDSLINE MED/95143782; van Brussel GH; Recognizing that drug addiction is a chronic health problem for which, in the majority of cases, no curative, effective treatment exists, Amsterdam developed a coherent system of public health measures. Data on the course of the local drug epidemic, including medical complications such as AIDS, tuberculosis and mortal
Idiopathic CD4+ T lymphocytopenia: a review and current perspective.: Transfus Med Rev. 1994 Oct;8(4):223-31. Unique Identifier : AIDSLINE MED/95143810; Heredia A; Hewlett IK; Soriano V; Epstein JS; Center for Biologics Evaluation and Research, Food and Drug; Administration, Rockville, MD 20852-1448.
Mortality after blood transfusion.: Transfus Med Rev. 1994 Oct;8(4):267-80. Unique Identifier : AIDSLINE MED/95143814; Vamvakas EC; Taswell HF; Department of Laboratory Medicine and Pathology, Mayo Clinic,; Rochester, MN.
Growth impairment, IGF I hyposecretion and thyroid dysfunction in children with perinatal HIV-1 infection.: Acta Paediatr. 1994 Oct;83(10):1029-34. Unique Identifier : AIDSLINE MED/95143841; Matarazzo P; Palomba E; Lala R; Ciuti E; Altare F; de Sanctis L; Tovo PA; Department of Paediatric Endocrinology, Regina Margherita; Children's Hospital, Turin, Italy.; We evaluated the growth pattern, bone age, insulin-like growth factor I (IGF I) secretion and thyroid function in 24 perinatally infected children: 9 asymptomatic or paucisymptomatic (group 1) and 15 with a more advanced disease state and treated with zidovudine (group 2). Statural and ponderal growth were compared wi
Ferritin levels in pediatric HIV-1 infection.: Acta Paediatr. 1994 Oct;83(10):1035-7. Unique Identifier : AIDSLINE MED/95143842; Ellaurie M; Rubinstein A; George Washington University School of Medicine, Washington, DC.; Ferritin is an acute phase protein which is often elevated in acute and chronic inflammation, as well as in neoplastic disease. In adults with human immunodeficiency virus (HIV) infection, elevated serum ferritin levels indicate advanced or progressive disease. In the present study, ferritin levels were evaluated in 8
Cerebrospinal fluid analysis in HIV-1-infected children: immunological and virological findings before and after AZT therapy.: Acta Paediatr. 1994 Oct;83(10):1038-42. Unique Identifier : AIDSLINE MED/95143843; Laverda AM; Gallo P; De Rossi A; Sivieri S; Cogo P; Pagliaro A; Chieco-Bianchi L; Tavolato B; Department of Paediatrics, University of Padua School of; Medicine, Padova, Italy.; Immunological and viral studies were conducted on cerebrospinal fluid from 31 HIV-1-infected children, of whom 23 were neurologically asymptomatic and 8 had progressive encephalopathy. After AZT treatment, a second cerebrospinal fluid specimen was obt
[Effects of Tripterygiitotorum in the treatment of insulin dependent diabetes mellitus with islet transplantation]: Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 Aug;14(8):451-3. Unique Identifier : AIDSLINE MED/95143895; Zhang XZ; Li S; Wu XZ; Division of Endocrinology, Ganquan Hospital, Shanghai Railway; Medical College.; The therapeutical efficacy of islet transplantation in treating insulin-dependent diabetes mellitus (IDDM) patients is marked for a short time and the long-term efficacy is unsatisfactory. So 30 IDDM patients given tripterygiitotorum (T II) were compared with 24 IDDM patients without using any immunosuppressive agents
Opiates: are there under-utilized and unexplored areas of prevention?: Addiction. 1994 Nov;89(11):1511-6. Unique Identifier : AIDSLINE MED/95144016; Strang J; National Addiction Centre, London, UK.; This paper explores the varied and potentially conflicting goals of preventive measures as applied to opiate use. These goals relate both to the overall extent of opiate use and the amount of harm arising from this drug use. Prevention involves the control both of the supply side and the demand for opiates. Particular
Opiate treatments.: Addiction. 1994 Nov;89(11):1551-8. Unique Identifier : AIDSLINE MED/95144022; Johns A; Division of Addictive Behaviour, St George's Hospital Medical; School, London, UK.; One of the greatest of challenges facing medicine is to devise effective and appropriate treatments for opiate problems. Such treatments are based on principles derived from the disciplines of pharmacology and psychology, but are also shaped by social issues and even by the views of practitioners. There are many misco
Clinical features of HIV infection in drug users of Manipur.: Natl Med J India. 1994 Nov-Dec;7(6):267-9. Unique Identifier : AIDSLINE MED/95144029; Panda S; Kamei G; Pamei M; Sarkar S; Sarkar K; Singh ND; Deb BC; Indian Council of Medical Research Unit for Research on AIDS,; North Eastern States of India, Salt Lake City, Calcutta, West; Bengal.; BACKGROUND. The human immunodeficiency virus was first detected in young intravenous drug users in Manipur in 1989 and it quickly reached a high prevalence in this group. Diagnostic facilities are scarce and it is thus important to suspect the presence of the infection by its clinical features. METHODS. We did a cross
AIDS, public health and the panic reaction (Part II).: Natl Med J India. 1994 Nov-Dec;7(6):288-91. Unique Identifier : AIDSLINE MED/95144034; Priya R; Jawaharlal Nehru University, New Delhi, India.
Studies on thermophile products. IX. Isofatty acid-containing phosphatidylglycerol that enhances the induction of concanavalin A-activated suppressor T cells.: Biol Pharm Bull. 1994 Sep;17(9):1171-5. Unique Identifier : AIDSLINE MED/95144089; Kohama Y; Semba T; Tanaka K; Tone H; Tanaka S; Itoh S; Mimura T; Faculty of Pharmaceutical Sciences, Osaka University, Japan.; A new enhancer of the induction of concanavalin A (Con A)-activated suppressor T (Ts) cells has been demonstrated in the ethanolysate of Bacillus stearothermophilus UBT8038. It was purified by successive silica gel column chromatographies and identified as phosphatidylglycerol with C14:0-C18:0 isofatty acids (Fr. 7-C)
Rhodococcus equi infection in HIV-positive patients: report of 5 cases and literature overview.: Monaldi Arch Chest Dis. 1994 Dec;49(5):380-8. Unique Identifier : AIDSLINE MED/95144128; Fiaccadori F; Elia GF; Calzetti C; Degli Antoni A; Magnani G; Cattedra di Malattie Infettive, Universita di Parma, Italia.; The importance of Rhodococcus equi infection, an uncommon human pathogen that almost exclusively affects immunocompromised hosts, has greatly increased following the advent of acquired immune deficiency syndrome (AIDS) epidemics. Until the present time, 38 cases of R. equi infection have been described in human immuno
Mycobacterial infections in AIDS: an overview of epidemiology, clinical manifestations, therapy and prophylaxis.: Monaldi Arch Chest Dis. 1994 Dec;49(5):432-8. Unique Identifier : AIDSLINE MED/95144138; Moroni M; Gori A; Rusconi S; Franzetti F; Antinori S; Clinic of Infectious Diseases, L. Sacco Hospital, University of; Milan, Italy.; One of the most frequent complications of AIDS is Mycobacterial infections. The incidence of tuberculosis has dramatically increased in all countries as a result of the HIV epidemic. Lately, it has been found that the natural history of new Mycobacterium tuberculosis infection is accelerated by HIV disease. In a wide
Establishment and characteristics of an interleukin-2-dependent STLV-1-producing lymphoid cell line, SPH-7(T), obtained from Papio hamadryas with malignant lymphoma [letter]: In Vitro Cell Dev Biol Anim. 1994 Oct;30A(10):637-9. Unique Identifier : AIDSLINE MED/95144368; Agrba V; Timanovskaya V; Kakubava V; Indzhiia L; Araviashvili D; Chikobava M; Lapin B
The negative tuberculin test: tuberculin, HIV, and anergy panels [letter; comment]: Am J Respir Crit Care Med. 1995 Feb;151(2 Pt 1):580. Unique Identifier : AIDSLINE MED/95144437; Friedman L; Dvorak HF
Differential expression of integrins alpha 6 and alpha 4 determines pathways in human peripheral CD4+ T cell differentiation.: Cell Adhes Commun. 1994 Oct;2(5):403-15. Unique Identifier : AIDSLINE MED/95144469; Schweighoffer T; Luce GE; Tanaka Y; Shaw S; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.; Integrins mediate leukocyte adhesion to vascular endothelium and thereby influence leukocyte recirculation. We have explored expression by peripheral blood T cells of beta 1 and beta 7 integrins, particularly alpha 4 beta 1 (VLA-4, CD49d), alpha 4 beta 7 (LPAM-1) and alpha 6 beta 1 (VLA-6, CD49f). Integrin expression
[Traumatic emergencies and AIDS]: Cah Anesthesiol. 1994;42(4):471-4. Unique Identifier : AIDSLINE MED/95144568; Abgrall J; Martin J; Granier H; Service de Medecine interne, Hopital d'Instruction des Armees; Clermont-Tonnerre, Brest Naval.; At the reception of traumatic casualties, the medical staff is exposed to a contact with blood and thus to the risk of H.I.V. contamination. The hollow needle used for taking blood simple or doing intravascular injections is the most dangerous instrument, especially in the period next to medical care. The prevention o
[Acute allograft glomerulopathy and its etiology]: Chung Hua I Hsueh Tsa Chih. 1994 Oct;74(10):615-7, 647. Unique Identifier : AIDSLINE MED/95144592; Liao LM; Shi BY; Li SL; Department of Urology, Beijing 309th Hospital.; Acute allograft glomerulopathy (AAG) is a distinctive glomerular lesion of renal allografts. Its clinical signs and symptoms, pathology and etiology were studied. The frequency of AAG was 57.6% in renal transplant recipients. The clinical signs and symptoms included urinary protein, cast, WBC and RBC, etc. The patholo
Human immunodeficiency virus protein gp120 interferes with beta-adrenergic receptor-mediated protein phosphorylation in cultured rat cortical astrocytes.: Cell Mol Neurobiol. 1994 Apr;14(2):159-73. Unique Identifier : AIDSLINE MED/95144734; Bernardo A; Patrizio M; Levi G; Petrucci TC; Laboratory of Cell Biology, Istituto Superiore di Sanita, Roma,; Italy.; 1. We have previously shown that acute exposure to the HIV coat protein gp120 interferes with the beta-adrenergic regulation of astroglial and microglial cells (Levi et al., 1993). In particular, exposure to 100 pM gp120 for 30 min depressed the phosphorylation of vimentin and glial fibrillary acidic protein (GFAP) in
Staphylococcal enterotoxin B modulates V beta 8+ TcR-associated T-cell memory against conventional antigen.: Cell Immunol. 1995 Jan;160(1):58-64. Unique Identifier : AIDSLINE MED/95144750; Bell SJ; Buxser SE; Section of Allergy/Immunology, East Carolina University School of; Medicine, Greenville, North Carolina 27858.; Primary in vivo challenge with the superantigen staphylococcal enterotoxin B (SEB) induces polyclonal proliferation of an unusually large proportion of circulating T-cells that bear the V beta 8-T-cell receptor (TcR) domain. Early and vigorous proliferation of V beta 8+ T-cells precedes their selective deletion, leavi
Changes of adhesion molecule (LFA-1, ICAM-1) expression on memory T cells activated with cytomegalovirus antigen.: Cell Immunol. 1995 Jan;160(1):8-13. Unique Identifier : AIDSLINE MED/95144754; Ito M; Watanabe M; Kamiya H; Sakurai M; Department of Pediatrics, Mie University School of Medicine,; Japan.; The expression of adhesion molecules (LFA-1, ICAM-1, CD29) on T cells activated with cytomegalovirus ( CMV ) antigen was investigated by three-color flow cytometry analysis. Peripheral blood mononuclear cells (PBMC) from CMV-se
Bone scintigraphy as a prognostic factor in patients with adult T-cell leukemia-lymphoma.: Clin Nucl Med. 1994 Nov;19(11):992-5. Unique Identifier : AIDSLINE MED/95144869; Hoshi H; Nagamachi S; Jinnouchi S; Ohnishi T; Shigemi F; Watanabe K; Department of Radiology, Miyazaki Medical College, Japan.; Bone scintigraphy in 26 patients with adult T-cell leukemia-lymphoma (ATLL) was evaluated. Abnormally high accumulations were observed in 7 of 26 patients (skull, 5; vertebra, 1; rib, 6; bony pelvis, 1; scapula, 2; lower extremities, 1). Serum calcium levels were significantly elevated in patients with abnormally high
Outcome of intensive care in patients with HIV infection.: Chest. 1995 Feb;107(2):506-10. Unique Identifier : AIDSLINE MED/95145063; De Palo VA; Millstein BH; Mayo PH; Salzman SH; Rosen MJ; Division of Pulmonary and Critical Care Medicine, Beth Israel; Medical Center, Albert Einstein College of Medicine, New York.; OBJECTIVES: To examine ICU admission rates and diagnoses of patients with HIV infection and to determine the outcomes of different critical illnesses. DESIGN: Consecutive enrollment of patients admitted to the ICU with confirmed HIV infection or an AIDS-defining diagnosis. SETTING: Medical ICU of an urban teaching hos
Fever, multiple pulmonary nodules, and ulcerated skin lesions in a patient with AIDS.: Chest. 1995 Feb;107(2):553-5. Unique Identifier : AIDSLINE MED/95145071; Jain NK; Lie TH; Respiratory Diseases Section, VAMC, Bay Pines, Florida.
What causes CD4+ T-lymphocytopenia? [letter; comment]: Chest. 1995 Feb;107(2):589-92. Unique Identifier : AIDSLINE MED/95145092; Gettler JF
[An immunohistochemical study of cornea and adjacent bulbar conjunctiva in Mooren's ulcer]: Chung Hua Yen Ko Tsa Chih. 1994 May;30(3):218-20. Unique Identifier : AIDSLINE MED/95145292; Wang Z; Chen JQ; Zheng HL; Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical; Sciences, Guangzhou.; The specimens of the corneal lesions and their adjacent bulbar conjunctivas taken from 14 cases with Mooren s ulcers were studied by immunohistochemical techniques to investigate the expression of HLA-DR antigen and the subgroups of lymphocytes. It is discovered that there is an aberrant expression of HLA-DR antigen i
[Prognosis of vertically infected children with HIV]: Dtsch Med Wochenschr. 1995 Feb 3;120(5):160-1. Unique Identifier : AIDSLINE MED/95145325; Bunikowski R; Grosch-Worner I; Kinderklinik und Poliklinik, Universitatsklinikum Rudolf; Virchow, Berlin.
Relationship between fluconazole sensitivity of Candida albicans isolates from HIV positive patients and serotype, adherence and CD4+ lymphocyte count.: Eur J Clin Microbiol Infect Dis. 1994 Sep;13(9):711-6. Unique Identifier : AIDSLINE MED/95145465; Imbert-Bernard C; Valentin A; Reynes J; Mallie M; Bastide JM; Laboratoire de Parasitologie-Immunologie, Faculte de Pharmacie,; Montpellier, France.; The sensitivity of fluconazole, serotype and adherence to buccal epithelial cells of 46 Candida albicans isolates was studied in vitro. Strains were isolated from 18 HIV-positive patients with variable CD4+ lymphocyte counts who were receiving long-term fluconazole therapy. Results showed that sensitivity to fluconazo
Clearance of Sendai virus by CD8+ T cells requires direct targeting to virus-infected epithelium.: Eur J Immunol. 1995 Jan;25(1):111-6. Unique Identifier : AIDSLINE MED/95145512; Hou S; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, TN 38105.; Minimal numbers of CD8+ T cells are found in bronchoalveolar lavage (BAL) populations recovered from Sendai virus-infected mice that are homozygous (-/-) for a beta 2-microglobulin (beta 2-m) gene disruption. The prevalence of the CD8+ set was substantially increased in the pneumonic lungs of 8-12-week radiation chime
T helper subset involvement in two high antibody responder lines of mice (Biozzi mice): HI (susceptible) and HII (resistant) to collagen-induced arthritis.: Eur J Immunol. 1995 Jan;25(1):132-6. Unique Identifier : AIDSLINE MED/95145516; De Franco M; Gille-Perramant MF; Mevel JC; Couderc J; Laboratoire d'Immunogenetique, Institut Curie, Paris, France.; CD4+ T helper cells play a critical role in the chronicity of collagen-induced arthritis (CIA) in mice. The present results focus on the involvement of Th1 and Th2 subsets at the initial stage of the experimental disease in two lines of mice selected for high antibody production: HI that is susceptible, and HII that i
CD4 T cells inhibit in vivo the CD8-mediated immune response against murine colon carcinoma cells transduced with interleukin-12 genes.: Eur J Immunol. 1995 Jan;25(1):137-46. Unique Identifier : AIDSLINE MED/95145517; Martinotti A; Stoppacciaro A; Vagliani M; Melani C; Spreafico F; Wysocka M; Parmiani G; Trinchieri G; Colombo MP; Division of Experimental Oncology D, Istituto Nationale per lo; Studio e la Cura dei Tumori, Milano, Italy.; Retroviral-mediated cytokine gene transfer into tumor cells is a highly effective way of inducing tumor inhibition and immunity. We analyzed the tumorigenicity of C-26 murine colon carcinoma cells transduced with genes encoding the two subunits of murine interleukin-12 (IL-12) in a polycistronic retroviral vector and
Insertion of a short human immunodeficiency virus (HIV)-2 gp36 sequence into an HIV-1 p24 recombinant protein results in a polypeptide with potent and TCRBV-restricted T cell triggering activity.: Eur J Immunol. 1995 Jan;25(1):218-25. Unique Identifier : AIDSLINE MED/95145530; Imberti L; Sottini A; Quiros Roldan E; Albertini A; Mattioli S; Prati E; Primi D; III Laboratorio Analisi, Spedali Civili, Brescia, Italy.; In the present work we investigate whether artificial alterations of the structure of an inactive retrovirus-encoded protein could transform it in a superantigen. As a model system we used a recombinant human immunodeficiency virus (HIV)-1 p24 protein and two of its variants in which a short peptide corresponding to s
Effect of anti-V3 antibodies on cell-free and cell-to-cell human immunodeficiency virus transmission.: Eur J Immunol. 1995 Jan;25(1):226-31. Unique Identifier : AIDSLINE MED/95145531; Pantaleo G; Demarest JF; Vaccarezza M; Graziosi C; Bansal GP; Koenig S; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.; The present study was undertaken to compare the effects of a type-specific (HIV-1 MN) anti-V3 antibody on in vitro human immunodeficiency virus (HIV) infection of peripheral blood mononuclear cells in systems of cell-free versus cell-to-cell transmission of virus. Anti-V3 antibody completely prevented HIV-1 infection
Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E2 critically depends on interleukin-2.: Eur J Immunol. 1995 Jan;25(1):59-63. Unique Identifier : AIDSLINE MED/95145553; Hilkens CM; Vermeulen H; van Neerven RJ; Snijdewint FG; Wierenga EA; Kapsenberg ML; Department of Cell Biology and Histology, University of; Amsterdam, The Netherlands.; Prostaglandin E2 (PGE2) favors T helper type 2 (Th2)-like cytokine secretion profiles in murine and human CD4+ T cells by inhibiting the production of the Th1-associated cytokines interleukin-2 ( IL-2 ) and interferon-gamma (IFN-gamma) and up-regulating the production of
Mobility of Scottish injecting drug users and risk of HIV infection.: Eur J Epidemiol. 1994 Aug;10(4):387-92. Unique Identifier : AIDSLINE MED/95145649; Goldberg DJ; Frischer M; Taylor A; Green ST; McKeganey N; Bloor M; Reid D; Cossar J; Scottish Centre for Infection and Environmental Health, Glasgow,; UK.; Nine hundred and nineteen injecting drug users (IDUs) were interviewed in Glasgow, Scotland during 1990 and 1991, as part of a wider study of HIV risk behaviour, about their injecting and sexual behaviour outside the city in the previous two years. Forty-five percent of respondents injected outside Glasgow, 6% shared
Steady HIV prevalence among pregnant women in Marseille, France [letter]: Eur J Epidemiol. 1994 Aug;10(4):443-4. Unique Identifier : AIDSLINE MED/95145658; Tamalet C; Vignoli C; Blanc B; Gamerre M; de Boisse P; Leclaire M; de Micco P
Depression, HIV dementia, delirium, posttraumatic stress disorder (or all of the above) [clinical conference]: Gen Hosp Psychiatry. 1994 Nov;16(6):426-34. Unique Identifier : AIDSLINE MED/95145907; Freedman JB; O'Dowd MA; Wyszynski B; Torres JR; McKegney FP; Department of Psychiatry, Montefiore Medical Center/Albert; Einstein College of Medicine, Bronx, New York.; A 29-year-old single Puerto Rican woman with AIDS was admitted to the Medical Service for pneumonia, seen by the Psychiatric Consultation Service, an eventually transferred to the Inpatient Psychiatric Unit with several possible psychiatric diagnoses including major depression, HIV dem
Safety of plasma derivatives.: Haemostasis. 1994 Sep-Oct;24(5):311-23. Unique Identifier : AIDSLINE MED/95145974; Ingerslev J; Department of Clinical Immunology, University Hospital,; Aarhus/Skejby, Denmark.; In clinical treatment practice of substitution therapy involving a plasma component, numerous aspects related to recipient s safety are relevant to the physician. Since viral contaminants may be present in the donor blood, safety begins in the institution collecting raw plasma where donors are inquired about any unusu
[AIDS-related dementia]: Harefuah. 1994 Nov 1;127(9):293-5, 360. Unique Identifier : AIDSLINE MED/95145982; Ganem R; Auslaender L; Weiner P; Medical Dept. A, Hillel Yaffe Medical Center, Hadera.; Dementia is a common process in which there is gradual decrease in mental function due to disease of either cortical or subcortical structures. The numerous causes of dementia can be divided into those in which dementia is the primary manifestation, as in Alzheimer s disease, or se
Human immunodeficiency virus infection as risk factor for mother-to-child hepatitis C virus transmission; persistence of anti-hepatitis C virus in children is associated with the mother's anti-hepatitis C virus immunoblotting pattern.: Hepatology. 1995 Feb;21(2):328-32. Unique Identifier : AIDSLINE MED/95146032; Manzini P; Saracco G; Cerchier A; Riva C; Musso A; Ricotti E; Palomba E; Scolfaro C; Verme G; Bonino F; et al; Department of Gastroenterology, Molinette Hospital, Torino,; Italy.; To determine the rate of vertical transmission of hepatitis C virus (HCV), we prospectively studied 45 babies born to anti-HCV-positive women with or without concomitant infection with the human immunodeficiency virus (HIV). We performed a second-generation recombinant immunoblotting assay, alanine transaminase (ALT)
Parvovirus B19 infection in HIV-1 infected patients with anemia.: Infection. 1994 Sep-Oct;22(5):356-8. Unique Identifier : AIDSLINE MED/95146180; Gyllensten K; Sonnerborg A; Jorup-Ronstrom C; Halvarsson M; Yun Z; Dept. of Infectious Diseases, Huddinge Hospital, Sweden.; Serum samples were analysed for IgM and IgG antibodies to parvovirus by ELISA and for parvovirus B19 DNA by polymerase chain reaction (PCR) in 69 HIV-1 infected Swedish patients with anemia and in 37 HIV-1 infected subjects without anemia. In 5/69 anemic patients, parvovirus B19 DNA was detected despite the lack of Ig
A retrospective study of Nocardia infections associated with the acquired immune deficiency syndrome (AIDS) [letter]: Infection. 1994 Sep-Oct;22(5):362-4. Unique Identifier : AIDSLINE MED/95146183; Long PF
Toxic epidermal necrolysis in a patient suffering from acquired immune deficiency syndrome [letter]: Infection. 1994 Sep-Oct;22(5):365. Unique Identifier : AIDSLINE MED/95146184; Alfandari S; Beuscart C; Delaporte E; Senneville E; Mouton Y
Prevalence of HIV infection among hemodialysis patients in Turkey [letter]: Infection. 1994 Sep-Oct;22(5):366. Unique Identifier : AIDSLINE MED/95146185; Arik N; Akpolat T; Gunaydin M; Utas C; Suleymanlar G
Treatment of severe infections caused by penicillin-resistant pneumococci. Role of third generation cephalosporins.: Infection. 1994;22 Suppl 3:S161-6. Unique Identifier : AIDSLINE MED/95146190; Rubinstein E; Rubinovitch B; Infectious Diseases Unit, Chaim Sheba Medical Center,; Tel-Hashomer, Israel.; Penicillin resistance occurred soon after the discovery of penicillin, first in the test tube and subsequently in patients. The prevalence of invasive pneumococcal disease has been estimated to be as high as 15-18/100,000 in the elderly population and even higher in AIDS patients, children and the very old. While prev
Effects of a traditional Chinese herbal medicine, Kanzo-bushi-to, on the resistance of thermally injured mice infected with herpes simplex virus type 1.: Int J Immunopharmacol. 1994 Oct;16(10):855-63. Unique Identifier : AIDSLINE MED/95146223; Matsuo R; Ball MA; Kobayashi M; Herndon DN; Pollard RB; Suzuki F; Department of Internal Medicine, University of Texas Medical; Branch, Galveston 77555-0882.; The protective effect of Kanzo-bushi-to (TJS-038) was investigated on the opportunistic infection of herpes simplex virus type 1 (HSV) in thermally injured mice (TI-Mice). We have previously reported that TI-Mice were approximately 100 times more susceptible to HSV infection than normal mice (N-Mice) and that CD8+ sup
Neuroleptic malignant syndrome in an AIDS patient: clinical and pathological findings.: Ital J Neurol Sci. 1994 Sep;15(6):293-5. Unique Identifier : AIDSLINE MED/95146316; Gabellini AS; Pezzoli A; De Massis P; Casadei G; Grillo A; Sacquegna T; Servizio di Neurologia, Ospedale Maggiore, Bologna.; Neuroleptic malignant syndrome (NMS) has been recently described following therapy with non strictly neuroleptic drugs that alter dopaminergic function, such as sulpiride and metoclopramide, and might occur more easily in patients with functional or organic brain disorders. We observed an AIDS patient who suffered fro
The transtheoretical model of change and HIV prevention: a review.: Health Educ Q. 1994 Winter;21(4):471-86. Unique Identifier : AIDSLINE MED/95146351; Prochaska JO; Redding CA; Harlow LL; Rossi JS; Velicer WF; Department of Psychology, University of Rhode Island, Kingston.; The transtheoretical model of health behavior change is described and supporting empirical work is presented that reviews the central constructs of the model: the stages of change, processes of change, decisional balance, confidence, and temptation. Model-based applications to a broad range of problem behaviors are su
Using the health belief model to predict safer sex intentions of incarcerated youth.: Health Educ Q. 1994 Winter;21(4):487-97. Unique Identifier : AIDSLINE MED/95146352; Lux KM; Petosa R; Department of Health Promotion and Education, Ohio State; University, Columbus 43210.; The purpose of this study was to test constructs of an enhanced version of the health belief model (HBM) in predicting juvenile delinquents safer sex intentions. An accessible sample (n = 452) of incarcerated youth between the ages of 13-18 years from a midwestern state were subjects. HBM constructs were measured wit
Health education interventions among Native Americans: a review and analysis.: Health Educ Q. 1994 Winter;21(4):521-38. Unique Identifier : AIDSLINE MED/95146354; LeMaster PL; Connell CM; Department of Health Behavior and Health Education, University of; Michigan, Ann Arbor 48109-2029.; Relatively few health education interventions directed at preventive health behaviors and management of chronic illness among Native Americans have been reported in the literature. This article provides a selective review of health education interventions among Native Americans that address the prevention and manageme
Can the impossible profession help the impossible patient--is Freud relevant in the south Bronx?: J Am Acad Psychoanal. 1994 Fall;22(3):415-31; discussion 443-8. Unique Identifier : AIDSLINE MED/95146403; Travin S; Bluestone H; Bronx-Lebanon Hospital Center, Department of Psychiatry, NY; 10456.
The crucial and difficult role of the psychotherapist in the treatment of the HIV-positive patient.: J Am Acad Psychoanal. 1994 Fall;22(3):505-18. Unique Identifier : AIDSLINE MED/95146408; Schaffner B; William Alanson White Institute.
Transmission of the hepatitis-C virus by tissue transplantation.: J Bone Joint Surg Am. 1995 Feb;77(2):214-24. Unique Identifier : AIDSLINE MED/95146514; Conrad EU; Gretch DR; Obermeyer KR; Moogk MS; Sayers M; Wilson JJ; Strong DM; Northwest Tissue Center/Puget Sound Blood Center, Seattle,; Washington.; The hepatitis-C virus has been the most prevalent cause of chronic hepatitis in both blood and organ recipients. The introduction of a second-generation immunoassay for antibodies to the hepatitis-C virus (HCV 2.0) provided the opportunity to determine if the hepatitis-C virus can be transmitted through tissue transpl
Condom use relative to knowledge of sexually transmitted disease prevention, method of birth control, and past or present infection.: J Community Health. 1994 Dec;19(6):395-407. Unique Identifier : AIDSLINE MED/95146653; Fleisher JM; Senie RT; Minkoff H; Jaccard J; SUNY Health Science Center at Brooklyn, Department of Preventive; Medicine & Community Health, Brooklyn 11203.; The purpose of this study was to assess knowledge regarding STD spread and prevention, and to assess motivational and behavioral factors that influence the use of condoms to prevent STD acquisition among inner-city women at high risk for STD infection. In addition, the effect of past and/or current STD infection on a
AIDS in Thailand: a medical student's perspective.: J Community Health. 1994 Dec;19(6):417-31. Unique Identifier : AIDSLINE MED/95146655; Chow DC; Department of Medicine/Pediatrics, Bridgeport Hospital,; Connecticut 06610.; Acquired Immunodeficiency Syndrome (AIDS) has become the biggest problem facing the health profession of Thailand today. The Ministry of Public Health reports that there are 400,000 individuals in Thailand already infected with the Human Immunodeficiency Virus (HIV) and is predic
Institutional environments and organizational responses to AIDS.: J Health Soc Behav. 1994 Dec;35(4):349-69. Unique Identifier : AIDSLINE MED/95146739; Dill A; Department of Sociology, Brown University, Providence, RI 02912.; Drawing from theory on institutionalized organizational environments, this paper analyzes the actions of community-based service programs providing care for people with AIDS. The focus is on the interorganizational relations developed by the lead agencies in demonstration projects attempting to coordinate services in
HIV screening for healthcare providers: can we provide sense and sensibility without pride or prejudice? [editorial]: Infect Control Hosp Epidemiol. 1994 Oct;15(10):631-4. Unique Identifier : AIDSLINE MED/95146742; Henderson DK
HIV screening of surgeons and dentists: a cost-effectiveness analysis.: Infect Control Hosp Epidemiol. 1994 Oct;15(10):635-45. Unique Identifier : AIDSLINE MED/95146743; Sell RL; Jovell AJ; Siegel JE; Department of Health Policy and Management, Harvard School of; Public Health, Boston, MA.; OBJECTIVE: To assess the cost-effectiveness of human immunodeficiency virus (HIV) screening strategies of surgeons and dentists. DESIGN: We constructed a model to project costs and HIV transmissions prevented over 15 years for four screening scenarios: 1) one-time voluntary screening, 2) one-time mandatory screening,
Clinical practice and the perceived importance of identifying high risk patients.: J Hosp Infect. 1994 Oct;28(2):127-36. Unique Identifier : AIDSLINE MED/95146755; Cockcroft A; Elford J; Department of Occupational Health, Royal Free Hospital and School; of Medicine, London, UK.; The Royal Free NHS Trust is implementing a Universal Precautions policy for blood and body fluids. Anticipating the introduction of this policy, a questionnaire was sent to a sample of staff and students who work with patients or clinical specimens. The questionnaire covered: views about identifying high risk patien
Inactivation of human immunodeficiency virus type 1 by alcohols.: J Hosp Infect. 1994 Oct;28(2):137-48. Unique Identifier : AIDSLINE MED/95146756; van Bueren J; Larkin DP; Simpson RA; Laboratory of Hospital Infection, Central Public Health; Laboratory, London, UK.; Alcohols are commonly used as disinfectants for skin, surfaces and immersion of some medical instruments. Measurements of the activity of alcohols against human immunodeficiency virus type 1 (HIV-1) must take account of the compatibility of neutralizers used to stop the disinfectant reaction, and of toxicity to the ce
Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.: J Infect Dis. 1995 Feb;171(2):273-80. Unique Identifier : AIDSLINE MED/95146771; Secchiero P; Carrigan DR; Asano Y; Benedetti L; Crowley RW; Komaroff AL; Gallo RC; Lusso P; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.; A sensitive and specific polymerase chain reaction method for the detection of human herpesvirus 6 (HHV-6) DNA in serum or plasma has been developed. In total, 157 human serum or plasma samples were studied. HHV-6 DNA was detected in 6 (85.7%) of 7 children with exanthem subitum, 3 (23.1%) of 13 bone marrow transplant
Human immunodeficiency virus type 1 quantitative cell microculture as a measure of antiviral efficacy in a multicenter clinical trial.: J Infect Dis. 1995 Feb;171(2):305-11. Unique Identifier : AIDSLINE MED/95146775; Fiscus SA; DeGruttola V; Gupta P; Katzenstein DA; Meyer WA 3rd; LoFaro ML; Katzman M; Ragni MV; Reichelderfer PS; Coombs RW; Department of Microbiology and Immunology, University of North; Carolina, Chapel Hill.; A quantitative cell microculture assay (QMC) was used to measure the human immunodeficiency virus type 1 (HIV-1) peripheral blood mononuclear cell (PBMC)-associated titer in 109 subjects rolled in an open-label phase I/II study of didanosine monotherapy or combination ther
Association between anti-CD4 antibodies and a decline in CD4+ lymphocytes in human immunodeficiency virus type 1 seroconverters.: J Infect Dis. 1995 Feb;171(2):312-9. Unique Identifier : AIDSLINE MED/95146776; Keay S; Wecksler W; Wasserman SS; Margolick J; Farzadegan H; University of Maryland School of Medicine (Division of Infectious; Diseases), Johns Hopkins School of Hygiene and Public Health,; Baltimore, MD.; Serum specimens (n = 161) from 31 persons before and after human immunodeficiency virus type 1 (HIV-1) seroconversion were tested for anti-CD4 antibodies. These antibodies were detected by both ELISA and Western blot in 55% (17/31) of subjects when HIV-1 seroconversion was detected and in 26% (8/31) from sera obtained
Macrophages from human immunodeficiency virus-positive persons are defective in host defense against Histoplasma capsulatum.: J Infect Dis. 1995 Feb;171(2):320-7. Unique Identifier : AIDSLINE MED/95146777; Chaturvedi S; Frame P; Newman SL; Department of Internal Medicine, University of Cincinnati College; of Medicine, Ohio.; The phagocytic and fungistatic activity of monocyte-derived macrophages from human immunodeficiency virus (HIV)-positive persons against Histoplasma capsulatum yeasts was determined. Macrophages from HIV-positive patients were profoundly deficient in their capacity to recognize and bind H. capsulatum, but ingestion of
Human cytomegalovirus DNA is present in CD45+ cells in semen from human immunodeficiency virus-infected patients.: J Infect Dis. 1995 Feb;171(2):432-6. Unique Identifier : AIDSLINE MED/95146794; Rasmussen L; Morris S; Hamed K; Merigan TC; Center for AIDS Research, Stanford Univresity School of Medicine,; California 94305.; Human cytomegalovirus ( CMV ) DNA was detected and quantitated in both blood and semen cells from human immunodeficiency virus (HIV)-infected men with 100-800 CD4 cell counts/mm3. None of the 35 patients studied had demonstrabl
Immunization of chimpanzees with recombinant gp160, but not infection with human immunodeficiency virus type 1, induces envelope-specific Th1 memory cells.: J Infect Dis. 1995 Feb;171(2):437-40. Unique Identifier : AIDSLINE MED/95146795; Mannhalter JW; Fischer MB; Wolf HM; Kupcu Z; Barrett N; Dorner F; Eder G; Eibl MM; Immuno AG, Vienna, Austria.; The human immunodeficiency virus (HIV) type 1 envelope protein (recombinant [r] gp160)-induced T cell lymphokine release pattern of chimpanzees immunized with HIVIIIB rpg160 tested and compared with rpg160-induced lymphokine releases of T cells from unimmunized, HIV-1-infected chimpanzees. The results showed that infe
Sexually transmitted diseases and human immunodeficiency virus control in Malawi: a field study of genital ulcer disease.: J Infect Dis. 1995 Feb;171(2):451-5. Unique Identifier : AIDSLINE MED/95146799; Behets FM; Liomba G; Lule G; Dallabetta G; Hoffman IF; Hamilton HA; Moeng S; Cohen MS; Department of Medicine, University of North Carolina, Chapel Hill; 27599.; Men with genital ulcer disease (GUD) attending a clinic in Malawi were evaluated and treated with one of five drug regimens. Haemophilus ducreyi was isolated from 204 (26.2%) of 778 patients. Of 677 men, 198 (29.2%) had treponemes detected in ulcer material by direct immunofluoresc
Infection with human immunodeficiency virus type 1 among leprosy patients in Zaire [letter; comment]: J Infect Dis. 1995 Feb;171(2):502-4. Unique Identifier : AIDSLINE MED/95146813; Lucas SB; Fine PE; Sterne JA; Ponnighaus JM; Turner AC; De Cock KM; Zuckerman M
Human immunodeficiency virus type 1-infected patients with no disease progression display high-avidity antibody production to autologous V3 sequences [letter] [see comments]: J Infect Dis. 1995 Feb;171(2):509-11. Unique Identifier : AIDSLINE MED/95146817; Brostrom C; Sonnerberg A; Sallberg M
Human microsporidiosis in African AIDS patients with chronic diarrhea [letter]: J Infect Dis. 1995 Feb;171(2):515-6. Unique Identifier : AIDSLINE MED/95146821; Drobniewski F; Kelly P; Carew A; Ngwenya B; Luo N; Pankhurst C; Farthing M
Management of HIV infected pregnant women in Chonburi Hospital.: J Med Assoc Thai. 1994 Apr;77(4):213-9. Unique Identifier : AIDSLINE MED/95146914; Pinchun P; Department of Obstetrics & Gynecology, Chonburi Hospital,; Thailand.; This study on birth control methods used, and HIV infection protection of the HIV infected pregnant women in the obstetrics-gynecology department of Chonburi Hospital from 1 January 1990 to 31 December 1993 revealed that there were 27 HIV infected women with less than 24 weeks gestational age, using birth control meth
Cell-mediated transmission of human T cell lymphotropic virus type I to human malignant trophoblastic cells results in long-term persistent infection.: J Gen Virol. 1995 Jan;76 ( Pt 1):167-73. Unique Identifier : AIDSLINE MED/95146946; Liu X; Zachar V; Norskov-Lauritsen N; Aboagye-Mathiesen G; Zdravkovic M; Mosborg-Petersen P; Dalsgaard AM; Hager H; Ebbesen P; Department of Virus and Cancer, Danish Cancer Society, Aarhus.; We investigated permissiveness of the malignantly transformed trophoblast (choriocarcinoma) cell lines JAR, BeWo and JEG-3 to the human T cell lymphotropic virus type I (HTLV-I). After co-culture with the productively infected cell line MT-2 the choriocarcinoma cell lines were analysed for infection over a period of t
Differences in human immunodeficiency virus type 1 V3 sequences from patients with and without AIDS dementia complex.: J Gen Virol. 1995 Jan;76 ( Pt 1):175-80. Unique Identifier : AIDSLINE +; Kuiken CL; Goudsmit J; Weiller GF; Armstrong JS; Hartman S; Portegies P; Dekker J; Cornelissen M; Department of Virology, Academic Medical Centre, Amsterdam, The; Netherlands.; Paired serum and cerebrospinal fluid (CSF) samples from 10 AIDS patients with and 10 without AIDS dementia complex (ADC) were studied, in an attempt to uncover ADC-associated variation in V3 sequences. Sequences were obtained from four of the patients with and eight of those withou
Sequence of host-range determinants in the env gene of a full-length, infectious proviral clone of exogenous avian leukosis virus HPRS-103 confirms that it represents a new subgroup (designated J).: J Gen Virol. 1995 Jan;76 ( Pt 1):181-7. Unique Identifier : AIDSLINE GENBANK/Z36973; Bai J; Howes K; Payne LN; Skinner MA; Department of Molecular Biology, Institute for Animal Health,; Compton, Nr Newbury, Berks, UK.; A genomic DNA library was constructed, in a bacteriophage lambda vector, from line 0 chick embryo fibroblasts (CEFs) infected with HPRS-103, an exogenous avian leukosis virus (ALV; envelope subgroup J) recently isolated from meat-type chickens. The library was screened at high stringency using a full length RAV-1 (sub
A 2',5'-oligoadenylate analogue inhibits murine hepatitis virus strain 3 (MHV-3) replication in vitro but does not reduce MHV-3-related mortality or induction of procoagulant activity in susceptible mice.: J Gen Virol. 1995 Feb;76 ( Pt 2):373-80. Unique Identifier : AIDSLINE MED/95146978; Fingerote RJ; Cruz BM; Gorczynski RM; Fung LS; Hubbell HR; Suhadolnik RJ; Levy GA; Toronto General Hospital, Ontario, Canada.; Exposure of inbred mice to murine hepatitis virus strain 3 (MHV-3) causes a strain dependent spectrum of disease symptoms which correlates with induction of procoagulant activity (PCA) by macrophages. Previous studies have demonstrated a role for interferons in resistance to MHV-3 infection. These cytokines have both
CD30 (Ki-1)-positive anaplastic large-cell lymphomas in 13 patients with and 27 patients without human immunodeficiency virus infection: the first comparative clinicopathologic study from a single institution that also includes 80 patients with other human immunodeficiency virus-related systemic lymphomas.: J Clin Oncol. 1995 Feb;13(2):373-80. Unique Identifier : AIDSLINE MED/95147021; Tirelli U; Vaccher E; Zagonel V; Talamini R; Bernardi D; Tavio M; Gloghini A; Merola MC; Monfardini S; Carbone A; Division of Medical Oncology and AIDS, Cancer Center, Aviano,; Italy.; PURPOSE: CD30 (Ki-1)-positive anaplastic large-cell lymphoma (Ki-1 ALCL) rarely has been described in patients with human immunodeficiency virus (HIV) infection. The purpose of this study was to characterize further the clinicopathologic features of Ki-1 ALCL in patients with HIV infection and, for the first time, to
Phase I trial of escalating doses of interleukin-1 beta in combination with a fixed dose of interleukin-2.: J Clin Oncol. 1995 Feb;13(2):482-9. Unique Identifier : AIDSLINE MED/95147037; Triozzi PL; Kim JA; Martin EW; Young DC; Benzies T; Villasmil PM; Ohio State University Comprehensive Cancer Center, Columbus.; PURPOSE: Interleukin-1 (IL-1) and IL-2 have synergistic antitumor and myelostimulatory activities. We investigated the clinical and biologic effects of IL-1/IL-2 therapy. PATIENTS AND METHODS: Twenty patients with metastatic cancer, divided into five cohorts, were trea
Ethical issues near the end of life: a physician's perspective on caring for persons with AIDS.: J Palliat Care. 1994 Autumn;10(3):117-21. Unique Identifier : AIDSLINE MED/95147077; Kuhl DR; Palliative Care Program, St. Paul's Hospital, Vancouver, British; Columbia, Canada.
High-risk behaviors for HIV: a comparison between crack-abusing and opioid-abusing African-American women.: J Psychoactive Drugs. 1994 Jul-Sep;26(3):233-41. Unique Identifier : AIDSLINE MED/95147096; Cohen E; Navaline H; Metzger D; University of Pennsylvania/Veterans Administration Medical; Center, Center for Studies of Addiction, Philadelphia 19104.; High rates of unprotected sexual behaviors and the exchange of sex for crack have been reported among female crack cocaine users. This subpopulation of drug users is at significant risk for contracting and transmitting HIV and AIDS. To date, there has been no research comparing crack- and opioid-abusing women, particu
Injection drug users in the Midwest: an epidemiologic comparison of drug use patterns in four Ohio cities.: J Psychoactive Drugs. 1994 Jul-Sep;26(3):265-75. Unique Identifier : AIDSLINE MED/95147100; Siegal HA; Carlson RG; Wang J; Falck RS; Stephens RC; Nelson ED; Wright State University, School of Medicine, Substance Abuse; Intervention Programs, Dayton, Ohio 45401.; Variations in the drug use patterns of injection drug users (IDUs) can have important implications for public health efforts aimed at reducing drug abuse and the transmission of the human immunodeficiency virus. This article describes and compares the characteristics of IDUs living in four Ohio cities and compares Afr
Common themes in a group for female i.v. drug users who are HIV positive.: J Psychoactive Drugs. 1994 Jul-Sep;26(3):289-93. Unique Identifier : AIDSLINE MED/95147103; Hardesty L; Greif GL; Chase-Brexton Clinic, Baltimore, Maryland.
Loss of detectable antibody to hepatitis B surface antigen in immunized patients with hemophilia but without human immunodeficiency virus infection.: J Pediatr. 1995 Feb;126(2):269-71. Unique Identifier : AIDSLINE MED/95147123; Maris JM; Butler RB; Cohen AR; Division of Hematology, Children's Hospital of Philadelphia, PA; 19104.; We investigated the loss of detectable antibody directed against the hepatitis B surface antigen after immunization with hepatitis B vaccine in 55 patients who were seronegative for the human immunodeficiency virus and had hemophilia. Twenty percent of patients lost detectable antibody at a mean of 4.6 years after com
Congenital cytomegalovirus infection as a result of nonprimary cytomegalovirus disease in a mother with acquired immunodeficiency syndrome.: J Pediatr. 1995 Feb;126(2):293-5. Unique Identifier : AIDSLINE MED/95147127; Schwebke K; Henry K; Balfour HH Jr; Olson D; Crane RT; Jordan MC; Department of Medicine, St. Paul-Ramsey Medical Center, MN 55101.; A pregnant woman with acquired immunodeficiency syndrome had nonprimary cytomegalovirus ( CMV ) viremia and died of complications from Pneumocystis carinii pneumonia and CMV sinusitis and pneumonitis. A boy was delivered by ces
Efficacy of oral amphotericin B in AIDS patients with thrush clinically resistant to fluconazole.: J Med Vet Mycol. 1994;32(5):389-93. Unique Identifier : AIDSLINE MED/95147151; Dewsnup DH; Stevens DA; Department of Medicine, Santa Clara Valley Medical Center, San; Jose, California 95128-2699.; Reports of thrush clinically refractory to azoles in AIDS patients are increasing with the more widespread use of these agents. We studied our own oral preparation of amphotericin B in the treatment of two AIDS patients who developed oral thrush due to Candida glabrata after pr
Systemic fungal infections in Thailand.: J Med Vet Mycol. 1994;32(5):395-9. Unique Identifier : AIDSLINE MED/95147152; Imwidthaya P; Department of Microbiology, Siriaj Hospital, Mahidol University,; Bangkok, Thailand.; Between January 1988 and December 1993, 254 cases of systemic mycoses were recorded in Thailand . Between 1988 and 1991, the common mycoses were aspergillosis, candidosis and cryptococcosis. In 1992, cryptococcosis increased to 30 cases with 27 being AIDS related. In 1993, cryptoc
Frequencies of MMPI-168 code types among asymptomatic and symptomatic HIV-1 seropositive gay men.: J Pers Assess. 1994 Dec;63(3):574-8. Unique Identifier : AIDSLINE MED/95147187; Moore LH; van Gorp WG; Hinkin CH; Holston SG; Weisman JD; Satz P; Department of Veterans Affairs Medical Center, West Los Angeles,; CA.; Welsh codes of Minnesota Multiphasic Personality Inventory-168 (MMPI-168) profiles were calculated for 151 HIV-1 seropositive gay men and 27 gay seronegative controls. Although 99% of seropositives profiles were clinically elevated, the profile configurations among subjects were varied. These data document the presen
From the Food and Drug Administration.: JAMA. 1995 Feb 22;273(8):613. Unique Identifier : AIDSLINE MED/95147315; Nightingale SL; Office of Health Affairs, Rockville, MD 20857.
[Two cases of invasive pulmonary aspergillosis in non-immunocompromised hosts]: Nippon Kyobu Shikkan Gakkai Zasshi. 1994 Oct;32(10):1032-7. Unique Identifier : AIDSLINE MED/95147370; Sugimura S; Yoshida K; Oba H; Hashiguchi K; Nakajima M; Moriya O; Okimoto N; Niki Y; Soejima R; Department of Medicine, Kawasaki Medical School, Japan.; Invasive pulmonary aspergillosis generally occurs in immunocompromised hosts such as patients with leukemia, and other malignancies, who are receiving anti-cancer chemotherapy. In this report, two non-immunocompromised patients who developed invasive pulmonary aspergillosis are presented. Case 1: A 63-year-old man com
Subcutaneous immunoglobulin replacement in patients with primary antibody deficiencies: safety and costs [see comments]: Lancet. 1995 Feb 11;345(8946):365-9. Unique Identifier : AIDSLINE MED/95147593; Gardulf A; Andersen V; Bjorkander J; Ericson D; Froland SS; Gustafson R; Hammarstrom L; Jacobsen MB; Jonsson E; Moller G; et al; Department of Clinical Immunology, Karolinska Institute, Huddinge; University Hospital, Sweden.; Immunoglobulins (IgG) as replacement therapy in primary antibody deficiencies can be given as intramuscular injections, or as intravenous or subcutaneous infusions. Our aims were to obtain information on the frequency of adverse systemic reactions during subcutaneous therapy, the occurrence and intensity of tissue rea
Cautious optimism over new anti-HIV agents [news]: Lancet. 1995 Feb 11;345(8946):377-8. Unique Identifier : AIDSLINE MED/95147596; Montaner JS; O'Shaughnessy M
HIV testing in prison [letter; comment]: Lancet. 1995 Feb 11;345(8946):390. Unique Identifier : AIDSLINE MED/95147618; Flanigan TP
Efficacy of lamivudine on replication of hepatitis B virus in HIV-infected patients [letter]: Lancet. 1995 Feb 11;345(8946):396-7. Unique Identifier : AIDSLINE MED/95147629; Benhamou Y; Dohin E; Lunel-Fabiani F; Poynard T; Huraux JM; Katlama C; Opolon P; Gentilini M
Informed consent: information about the physician.: Med Law. 1994;13(5-6):467-72. Unique Identifier : AIDSLINE MED/95147658; Slovenko R; Wayne State University Law School, Detroit, MI.; Does the doctrine of informed consent require disclosure about the physician? Recent developments indicate that the doctrine requires information not only about the treatment but also about the physician. There is also modification in the requirement of proof of a causal nexus between the lack of informed consent an
Hepatitis delta virus in intravenous drug users in Kuala Lumpur.: Med J Malaysia. 1994 Sep;49(3):212-6. Unique Identifier : AIDSLINE MED/95147749; Duraisamy G; Zuridah H; Ariffin Y; Kek CS; Blood Services Centre, Hospital Kuala Lumpur.; The hepatitis delta virus (HDV) is an RNA containing virus that requires hepatitis B virus (HBV) to supply the envelope proteins. HDV only infect man in the presence of HBV, either as a coinfection or as superinfection in HBV carriers. In the presence of hepatitis B infection, the HDV may cause more severe liver damag
The gag proteins of human immunodeficiency virus type 1: mechanisms of virus assembly and possibilities for interference.: Med Microbiol Immunol (Berl). 1994 Sep;183(4):177-94. Unique Identifier : AIDSLINE MED/95147803; Modrow S; Kattenbeck B; von Poblotzki A; Niedrig M; Wagner R; Wolf H; Institut fur Medizinische Mikrobiologie und Hygiene der; Universitat Regensburg, Germany.
Trends in sexual risk behavior among high school students--United States, 1990, 1991, and 1993.: MMWR Morb Mortal Wkly Rep. 1995 Feb 24;44(7):124-5, 131-2. Unique Identifier : AIDSLINE MED/95147838; Since the early 1980s, adolescents in the United States have experienced high rates of unintended pregnancies (1) and sexually transmitted diseases (STDs) (2), including HIV infection (3). Since 1990, CDC s Youth Risk Behavior Surveillance System has enabled measurement of priority hea
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 7-1995. A 58-year-old man with common variable immunodeficiency, splenomegaly, and hemolytic anemia [clinical conference] [see comments]: N Engl J Med. 1995 Mar 9;332(10):663-71. Unique Identifier : AIDSLINE MED/95147938
[HIV infection in the Rijnmond area, 1985-1993: more transmission via heterosexual contact and drug use, and more female patients]: Ned Tijdschr Geneeskd. 1995 Jan 28;139(4):188-92. Unique Identifier : AIDSLINE MED/95148013; van der Ende ME; Gyssens IC; de Marie S; Afd. Inwendige Geneeskunde II, Academisch Ziekenhuis; Rotterdam-Dijkzigt, Rotterdam.; OBJECTIVE. To evaluate the characteristics of HIV infected patients in the Rijnmond region during 1985-1993. DESIGN. Descriptive. SETTING. University Hospital Rotterdam-Dijkzigt (AZR). METHOD. Data of medical records of all HIV infected patients in AZR were prospectively collected from 1988 on and retrospectively for
[Thymostimulin in clinical practice]: Orv Hetil. 1994 Dec 25;135(52):2871-5. Unique Identifier : AIDSLINE MED/95148202; Lengyel G; Feher J; Semmelweis Orvostudomanyi Egyetem, II. Belklinika, Budapest.; In insufficient function of bone marrow thymostimulin has an important role in the proliferation of haemopoetic cells, take part in the regeneration of lymphocytes, as well as in the normalisation processes of T lymphocytes. Its advantageous effect has been demonstrated in different viral infections, thus in herpes si
Mutational hot spots within the carboxy terminal region of the LMP1 oncogene of Epstein-Barr virus are frequent in lymphoproliferative disorders.: Oncogene. 1995 Feb 2;10(3):523-8. Unique Identifier : AIDSLINE MED/95148223; Knecht H; Bachmann E; Brousset P; Rothenberger S; Einsele H; Lestou VS; Delsol G; Bachmann F; Ambros PF; Odermatt BF; Department of Internal Medicine, CHUV University Hospital,; Lausanne, Switzerland.; We have recently identified in Epstein-Barr virus (EBV) positive Hodgkin s disease (HD) a variant of the latent membrane protein 1 (LMP1) oncogene characterized by four point mutations and a 30 base pair deletion. These findings led us to test whether such mutants were also present in other lymphoproliferative disorde
High failure rate of dapsone and pentamidine as Pneumocystis carinii pneumonia prophylaxis in human immunodeficiency virus-infected children.: Pediatr Infect Dis J. 1994 Nov;13(11):1004-6. Unique Identifier : AIDSLINE MED/95148265; Nachman SA; Mueller BU; Mirochnick M; Pizzo PA; Department of Pediatrics, HSC SUNY Stony Brook 11794-8111.
Tuberculosis in human immunodeficiency virus-exposed or -infected United States children.: Pediatr Infect Dis J. 1994 Nov;13(11):963-8. Unique Identifier : AIDSLINE MED/95148296; Gutman LT; Moye J; Zimmer B; Tian C; Department of Pediatrics, Duke University Medical Center, Durham,; NC 27710.; This study was designed to provide a preliminary assessment of the occurrence of tuberculosis exposure, infection and disease within a national sample of infants and children with human immunodeficiency virus (HIV) exposure or infection, and to determine the prevalence of Mycobacterium tuberculosis isolates resistant
Prevention of HIV and STD infections.: Prev Med. 1994 Sep;23(5):655-60. Unique Identifier : AIDSLINE MED/95148493; Chesney MA; Center for AIDS Prevention Studies, School of Medicine,; University of California at San Francisco 94105.; The objective of this paper is to identify the key research questions that need to be addressed in order to improve our prevention efforts in the areas of HIV and other STDs. First, the dimension of the problem posed by HIV and other STDs will be summarized. Second, evidence of an epidemiologic synergy between HIV and
[Pneumocystis carinii pneumonia with recurrent pneumothorax and pleuritis]: Pneumologie. 1994 Dec;48(12):837-40. Unique Identifier : AIDSLINE MED/95148517; Theegarten D; Philippou S; Zaboura G; Abteilung fur Pathologie, Ruhr-Universitat Bochum.; A report on three HIV-positive patients with recurrent pneumothorax in pneumocystis carinii pneumonia on whom partial parietal pleurectomy and in two cases also a wedge-shaped pulmonary resection were performed. Histology revealed granulomatous necrotising pneumonia involving the visceral pleura, and a partly honeycom
Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1.: Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):826-30. Unique Identifier : AIDSLINE MED/95148630; Weissman D; Li Y; Ananworanich J; Zhou LJ; Adelsberger J; Tedder TF; Baseler M; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.; Conflicting data have been reported with regard to the infectability, dysfunction, and depletion of dendritic cells (DCs) in human immunodeficiency virus (HIV) disease. These discrepancies could potentially be explained by the existence of multiple subsets of cells with dendritic morphology in peripheral blood. The is
Death from inside out: an overview.: Philos Trans R Soc Lond B Biol Sci. 1994 Aug 30;345(1313):237-41. Unique Identifier : AIDSLINE MED/95148691; Wyllie AH; Department of Pathology, University Medical School, Edinburgh,; U.K.; Although a type of cell death strategically suited to participating in developmental processes has been well known for nearly thirty years, it is only in the recent past that the extraordinary ubiquity of such death has been appreciated. Apoptosis, a term first employed to describe such death defined in structural ter
Psychosocial self-prognosis in relation to mortality and morbidity in hemophiliacs with HIV infection.: Psychother Psychosom. 1994;62(3-4):185-92. Unique Identifier : AIDSLINE MED/95148843; Blomkvist V; Theorell T; Jonsson H; Schulman S; Berntorp E; Stiegendal L; National Institute of Psychosocial Factors and Health, Stockholm,; Sweden.; HIV-infected hemophiliacs participated in a psychosocial prognosis study. The Coping Wheel was filled out 1-2 years after the subjects had been told that they were HIV-infected and between 1 and 7 years after they had become infected. The number of significant signs of disease as well as mortality were recorded during
[Differences in the cellular response of the immune system in patients with Paget's disease of bone after elcatonin and etidronate administration]: Rev Clin Esp. 1994 Nov;194(11):970-3. Unique Identifier : AIDSLINE MED/95148941; Rapado A; Lopez Gavilanes E; Palomino P; Yague M; de la Piedra C; Diaz Curiel M; Ortiz F; Servicio de Medicina Interna (Unidad Metabolica), Fundacion; Jimenez Diaz y Universidad Autonoma, Madrid.; A cellular immunological defect is present in patients with Paget s disease of the bone. Low counts of CD4, high counts of CD8, and a low CD4/CD8 ratio were observed in 58 patients compared with controls. These findings were not correlated with the metabolic activity of the disease. After therapy with Elcatonine an im
Proceedings of the Conference Quantitative Methods for Studying AIDS. Blaubeuren, Germany, 14-18 June 1993.: Stat Med. 1994 Oct 15-30;13(19-20):1899-2187. Unique Identifier : AIDSLINE MED/95148990
Studies of AIDS and HIV surveillance. Screening tests: can we get more by doing less?: Stat Med. 1994 Oct 15-30;13(19-20):1905-19. Unique Identifier : AIDSLINE MED/95148991; Tu XM; Litvak E; Pagano M; Department of Mathematics and Statistics, University of; Pittsburgh, PA 15240.; Estimating the prevalence of the human immunodeficiency virus (HIV) in a group is challenging; this is especially so when the prevalence is small. One reason is that the presence of measurement errors resulting from the limited precision of tests makes estimation, using traditional methods, impossible in some screenin
Seasonal and other short-term influences on United States AIDS incidence.: Stat Med. 1994 Oct 15-30;13(19-20):1921-31. Unique Identifier : AIDSLINE MED/95148992; Bacchetti P; Department of Epidemiology and Biostatistics, University of; California, San Francisco 94143-0840.; This paper models monthly AIDS diagnosis counts in terms of smooth secular trend, calendar month effects, and the number of workdays per month. A parameterization of month effects allows separation of true seasonal effects from a linear trend over the calendar year and an arbitrary June effect. There is strong evidenc
Prediction and validation in the public health modelling of HIV/AIDS.: Stat Med. 1994 Oct 15-30;13(19-20):1933-43. Unique Identifier : AIDSLINE MED/95148993; Bailey NT; Mathematical models are an integral part of long-range scientific research and are broadly equivalent to the hypotheses to be tested. Validation consists: (1) in checking whether theoretical expectations are sufficiently close to observed values; and (2) in showing that theoretical constructions that pass the first te
Dependent HIV incidences in back-projection of AIDS incidence data.: Stat Med. 1994 Oct 15-30;13(19-20):1945-58. Unique Identifier : AIDSLINE MED/95148994; Becker NG; Chao X; Department of Statistics, La Trobe University, Bundoora VIC,; Australia.; Techniques for reconstructing plausible HIV incidence curves from AIDS incidence data are called methods of back-projection, or back-calculation. Approaches to back-projection tend to make the simplifying assumption that the quarterly HIV incidences are independent, which is not even approximately true. Here we invest
Using time of first positive HIV test and other auxiliary data in back-projection of AIDS incidence.: Stat Med. 1994 Oct 15-30;13(19-20):1959-74. Unique Identifier : AIDSLINE MED/95148995; Marschner IC; Department of Biostatistics, Harvard School of Public Health,; Boston, MA 02115.; Estimation of HIV incidence by the method of back-projection typically uses data on the time of diagnosis of AIDS cases, together with known information about the incubation distribution of AIDS. This paper discusses back-projection using auxiliary data on AIDS cases, particularly the time of first positive HIV test.
Backcalculation models of age-specific HIV incidence rates.: Stat Med. 1994 Oct 15-30;13(19-20):1975-90. Unique Identifier : AIDSLINE MED/95148996; Rosenberg PS; National Cancer Institute, Epidemiologic Methods Section,; Rockville, Maryland 20892.; This paper extends the use of backcalculation to estimate past incidence of HIV infection in different age groups from age-specific counts of AIDS incidence. The approach is flexible and allows the distribution of age at HIV infection to change over time. In this new approach, the incubation distributions used to back
Back-projection of German AIDS data using information on dates of tests.: Stat Med. 1994 Oct 15-30;13(19-20):1991-2008. Unique Identifier : AIDSLINE MED/95148997; Dietz K; Seydel J; Schwartlander B; Department of Medical Biometry, Eberhard-Karls-University,; Tubingen, Germany.; The paper presents an application of back-projection methods to the reported AIDS data which are collected by the AIDS Center in the Federal Office of Health, Berlin. The analysis is based on all data reported up to 31 December 1992. The data are broken down by major risk groups. Correction for reporting delays takes
Incorporating HIV test data into forecasts of the AIDS epidemic in Scotland.: Stat Med. 1994 Oct 15-30;13(19-20):2009-20. Unique Identifier : AIDSLINE MED/95148998; Raab GM; Fielding KL; Allardice G; MRC Biostatistics Initiative for HIV and AIDS in Scotland,; Edinburgh, U.K.; For AIDS cases in Scotland the date of HIV antibody positive diagnosis (HIV test date) is recorded on the AIDS case reports. Data are also available on the total numbers of individuals with HIV positive test reports in Scottish laboratories in each year since testing became available. These data are incorporated into
The effect of covariates on the induction time of AIDS using improved imputation of exact seroconversion times.: Stat Med. 1994 Oct 15-30;13(19-20):2021-30. Unique Identifier : AIDSLINE MED/95148999; Gauvreau K; Degruttola V; Pagano M; Bellocco R; Harvard School of Public Health, Department of Biostatistics,; Boston, Massachusetts 02115.; This paper explores the effects of covariates such as age, gender, chronological time of seroconversion, and mode of virus transmission on the interval between HIV seroconversion and the development of AIDS. For many cohorts which are available to provide information about such effects, both the time of seroconversion
Distribution of the latency period for perinatally acquired AIDS.: Stat Med. 1994 Oct 15-30;13(19-20):2031-42. Unique Identifier : AIDSLINE MED/95149000; Mawhinney S; Pagano M; Department of Biostatistics, Harvard School of Public Health,; Boston, MA 02115.; In the United States , over 86 per cent of paediatric cases of acquired immunodeficiency syndrome (AIDS) were infected through maternal or perinatal transmission and current estimates suggest that approximately 6000 children are born to infected women each year. In industrialized countr
Non-parametric analysis of transfusion-related HIV and AIDS incidence data.: Stat Med. 1994 Oct 15-30;13(19-20):2043-58. Unique Identifier : AIDSLINE MED/95149001; Motika M; Becker NG; Wylie B; Learmont J; Kaldor J; Department of Statistics, La Trobe University, Bundoora VIC,; Australia.; The method for making non-parametric inferences about the probability distribution of the incubation period for AIDS from transfusion-related AIDS data is extended to include data on individuals who have tested positive for HIV but do not have AIDS at the time of analysis. The method is illustrated with data on indivi
Marker values at the time of an AIDS diagnosis.: Stat Med. 1994 Oct 15-30;13(19-20):2059-66. Unique Identifier : AIDSLINE MED/95149002; Taylor JM; Kim DK; Department of Biostatistics, University of California, Los; Angeles 90024-1772.; In this paper statistical methods are proposed to estimate the distribution of a CD4 T-cell number at the time of a clinical AIDS endpoint from serial measurements of CD4 T-cell values in a cohort study. The statistical formulation of the problem is that of survival analysis with interval censored data, but in which t
A model for AIDS pathogenesis.: Stat Med. 1994 Oct 15-30;13(19-20):2067-79. Unique Identifier : AIDSLINE MED/95149003; Schenzle D; Department of Medical Biometry, University of Tubingen, Germany.; The idea is put forward and analysed numerically, that within an infected person HIV evolves to increase its reproductivity within the population of CD4+ cells. A mathematical model predicts initial viremia and CD4+ cell drop after HIV infection and thereafter a slow progressive decline in the number of CD4+ cells, al
Non-parametric estimation and doubly-censored data: general ideas and applications to AIDS.: Stat Med. 1994 Oct 15-30;13(19-20):2081-95. Unique Identifier : AIDSLINE MED/95149004; Jewell NP; Division of Biostatistics, University of California, Berkeley; 94720.; In many epidemiologic studies of human immunodeficiency virus (HIV) disease, interest focuses on the distribution of the length of the interval of time between two events. In many such cases, statistical estimation of properties of this distribution is complicated by the fact that observation of the times of both even
Modelling the female-to-male per-act HIV transmission probability in an emerging epidemic in Asia.: Stat Med. 1994 Oct 15-30;13(19-20):2097-106. Unique Identifier : AIDSLINE MED/95149005; Satten GA; Mastro TD; Longini IM Jr; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, GA 30333.; The per-sexual-act probability of transmission of the human immunodeficiency virus type 1 (HIV) from an infected person to a susceptible sex partner can be determined from a simple model if the number of contacts each study participant has with infected partners is known. The unusual epidemiologic situation in the eme
Considerations in choice of a clinical endpoint for AIDS clinical trials. Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA).: Stat Med. 1994 Oct 15-30;13(19-20):2107-25. Unique Identifier : AIDSLINE MED/95149006; Neaton JD; Wentworth DN; Rhame F; Hogan C; Abrams DI; Deyton L; Division of Biostatistics, School of Public Health, University of; Minnesota, Minneapolis 55414.; In most clinical trials of antiretroviral therapy for patients infected with HIV, the major outcome variable has been the combined clinical endpoint of any new or recurrent AIDS defining event. We review features of combined endpoints and use data from the Terry Beirn Community Programs for Clinical Research on AIDS (
The effectiveness of interventions on incubation of AIDS as measured by secular increases within a population.: Stat Med. 1994 Oct 15-30;13(19-20):2127-39. Unique Identifier : AIDSLINE MED/95149007; Hoover DR; Munoz A; He Y; Taylor JM; Kingsley L; Chmiel JS; Saah A; Department of Epidemiology, Johns Hopkins School of Public; Health, Baltimore, MD 21205.; Methods are developed to estimate and test for the impact of intervention use on a population s survival function (time to AIDS). Each participant s history is divided into J + 1 components: omega 0 occurring before the intervention is available and omega 1 to omega J occurring later, as the intervention becomes succe
Assessing drug compliance using longitudinal marker data, with application to AIDS.: Stat Med. 1994 Oct 15-30;13(19-20):2141-53. Unique Identifier : AIDSLINE MED/95149008; Kim HM; Lagakos SW; Department of Biostatistics, Harvard School of Public Health,; Boston, MA 02115.; The assessment of non-compliance to a study medication is an important issue in the evaluation of clinical trials of self-administered drugs. Traditional methods for evaluating the compliance of subjects include self-reported questionnaires and pharmacologic assays of drug levels in randomly-drawn blood samples, but e
Some statistical issues in HIV vaccine trials.: Stat Med. 1994 Oct 15-30;13(19-20):2155-77. Unique Identifier : AIDSLINE MED/95149009; Rida WN; Lawrence DN; Biostatistics Research Branch, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892.; Efficacy trials of prophylactic HIV vaccines will be among the most difficult clinical trials ever attempted. Not only will there be challenges with the recruitment and retention of high-risk uninfected individuals, there will be many statistical challenges to the design, conduct, analysis, and interpretation of these
A method for evaluating needle exchange programmes.: Stat Med. 1994 Oct 15-30;13(19-20):2179-87. Unique Identifier : AIDSLINE MED/95149010; Kaplan EH; Yale School of Management, New Haven, Connecticut.; This paper details a statistical method for evaluating needle exchange programmes. The approach relies only on needle exchange operations data and the results of HIV tests conducted on needles. We develop statistical models describing the needle infection process and how needle exchange interrupts this process. The me
[Upper influx distension in a patient with HIV; unusual localization of an HIV-associated lymphoma]: Schweiz Rundsch Med Prax. 1995 Jan 17;84(3):76-81. Unique Identifier : AIDSLINE MED/95149024; Beltinger J; Schonenberger R; Departement Innere Medizin, Universitatskliniken, Kantonsspital; Basel.; A 33 year old patient was admitted to the hospital because of deteriorated general condition, upper abdominal pain and progressive dyspnea. He had a positive HIV-serology associated with i.v. drug abuse. The CDC classification on admission was B1. There was no history of opportunistic infections, the patient had refus
A profile of HIV-risk behaviours among travellers--a population based study of Danes visiting Greenland.: Scand J Soc Med. 1994 Sep;22(3):204-8. Unique Identifier : AIDSLINE MED/95149073; Melbye M; Biggar RJ; Epidemiology Research Unit, State Serum Institute, Copenhagen,; Denmark.; The population of Greenland has behavioural characteristics that indicate a high risk of HIV spread once HIV is introduced into the population. Much depends, however, on the degree of exposure from visitors, particularly in an initi
Cigarette smoking and drinking of alcohol are not associated with rapid progression to acquired immunodeficiency syndrome among homosexual men in Norway.: Scand J Soc Med. 1994 Sep;22(3):209-12. Unique Identifier : AIDSLINE MED/95149074; Eskild A; Petersen G; Department of Epidemiology, National Institute of Public Health,; Oslo, Norway.; In order to study the influence of cigarette smoking and drinking of alcohol on the progression to acquired immunodeficiency syndrome (AIDS), eighty HIV infected homosexual men were included in a prospective study from the date of diagnosed HIV seropositivity. Two men were lost to follow-up. The mean follow-up time wa
Firm behavior in the U.S. market for factor VIII: a need for policy?: Soc Sci Med. 1994 Dec;39(12):1591-603. Unique Identifier : AIDSLINE MED/95149158; Nauenberg E; Sullivan SD; Department of Social and Administrative Health Sciences,; University of California, Berkeley 94720.; In this paper, we historically examine the market for Factor VIII concentrate, a collection of blood products used in the treatment of hemophilia A. With the introduction of HIV-1 into the U.S. blood supply, a majority of American hemophiliacs became infected with the virus. In response to contamination, the pharmaceu
Sexual behaviour in Kenya: implications for sexually transmitted disease transmission and control.: Soc Sci Med. 1994 Dec;39(12):1649-56. Unique Identifier : AIDSLINE MED/95149164; Moses S; Muia E; Bradley JE; Nagelkerke NJ; Ngugi EN; Njeru EK; Eldridge G; Olenja J; Wotton K; Plummer FA; et al; Department of Community Health, University of Nairobi, Kenya.; Sexual behaviour in Kenya in relation to STD transmission was investigated with a view to forming a basis for the more rational design of STD/HIV control interventions. Questionnaires were administered to a sample of 762 men and women attending eight health facilities in two urban c
[When can tuberculosis be eradicated in Denmark?]: Ugeskr Laeger. 1995 Jan 16;157(3):273-9. Unique Identifier : AIDSLINE MED/95149379; Kok-Jensen A; Lungeklinikken/afdeling P., Bispebjerg Hospital, Kobenhavn.; Eradication is here defined as a tuberculosis (tbc.) incidence below one case of contagious tbc. per million per year and a Mycobacterium tuberculosis (Mt) infection prevalence of 1% or lower and declining. The situation is evaluated separately for Danes and foreigners. Late cases of tbc due to Mt infection more than
[Progressive multifocal leukoencephalopathy]: Ugeskr Laeger. 1995 Jan 16;157(3):284-8. Unique Identifier : AIDSLINE MED/95149381; Hansen NJ; Madsen C; Stenager E; Neuromedicinsk afdeling N, Odense Universitetshospital.; Progressive multifocal leucoencephalopathy (PML) is a rarely occurring demyelinating disease of the central nervous system caused by a neurotropic papovavirus named JC virus (JCV). The most frequently affected areas are the cerebral hemispheres, especially the parieto-occipital region, followed by the cerebellum and b
Cytologic appearance of Rhodococcus equi in bronchoalveolar lavage specimens. A case report.: Acta Cytol. 1995 Jan-Feb;39(1):111-3. Unique Identifier : AIDSLINE MED/95149611; Lachman MF; Department of Anatomic Pathology, Yale University School of; Medicine, New Haven, Connecticut 06510.; Immunocompromised patients are at risk of developing infections caused by Rhodococcus equi, a gram-positive bacillus that can cause pneumonia in patients with acquired immunodeficiency syndrome. To the author s knowledge this is the first report describing the cytologic features of the infection in a patient who had a
Fine needle aspiration cytology of mycobacterial spindle cell pseudotumor. A case report.: Acta Cytol. 1995 Jan-Feb;39(1):125-8. Unique Identifier : AIDSLINE MED/95149614; Corkill M; Stephens J; Bitter M; Department of Pathology, University of Colorado Health Sciences; Center, Denver.; We report a case of mycobacterial spindle cell pseudotumor (MSP) in a lymph node from an acquired immunodeficiency syndrome patient diagnosed by fine needle aspiration (FNA). The FNA cytology was characterized by spindle cell proliferation without the typical foamy histiocytes usually seen in mycobacterial infections
Diagnosis of progressive multifocal leukoencephalopathy by stereotactic brain biopsy utilizing immunohistochemistry and the polymerase chain reaction.: Acta Cytol. 1995 Jan-Feb;39(1):35-44. Unique Identifier : AIDSLINE MED/95149621; Silver SA; Arthur RR; Erozan YS; Sherman ME; McArthur JC; Uematsu S; Department of Pathology, Johns Hopkins Medical Institutions,; Baltimore, Maryland.; This report describes the diagnosis of progressive multifocal leukoencephalopathy (PML) in nine patients using cytopathologic and histopathologic examination of computed tomographically guided stereotactic brain biopsies in combination with immunostaining for SV-40-related antigen and the polymerase chain reaction (PC
Phenotypic analysis of cerebrospinal fluid cells over the course of Lyme meningoradiculitis.: Acta Cytol. 1995 Jan-Feb;39(1):73-5. Unique Identifier : AIDSLINE MED/95149627; Sindern E; Malin JP; Department of Neurology, Ruhr University, Kliniken Bergmannsheil,; Bochum, Germany.; Cytologic cerebrospinal fluid abnormalities that most distinctly point to the diagnosis of Lyme meningoradiculitis are pronounced mononuclear pleocytosis composed mainly of T lymphocytes, large amounts of plasma cells and IgM-positive B cells. In this study, repeat examinations revealed decreasing cell numbers and alm
Parkinson's disease and immunological abnormalities: increase of HLA-DR expression on monocytes in cerebrospinal fluid and of CD45RO+ T cells in peripheral blood.: Acta Neurol Scand. 1994 Sep;90(3):160-6. Unique Identifier : AIDSLINE MED/95149672; Fiszer U; Mix E; Fredrikson S; Kostulas V; Link H; Institute of Psychiatry and Neurology, Warsaw, Poland.; The etiology of Parkinson s disease is mainly unknown. Immune abnormalities have been described, but the cause of such abnormalities has not been resolved. We examined by two-colour flow cytometry HLA-DR antigen expression on monocytes from cerebrospinal fluid (CSF) and blood and, moreover, lymphocyte subpopulations (
Persistent enhancement after treatment for cerebral toxoplasmosis in patients with AIDS: predictive value for subsequent recurrence.: AJNR Am J Neuroradiol. 1994 Oct;15(9):1773-8. Unique Identifier : AIDSLINE MED/95149874; Laissy JP; Soyer P; Parlier C; Lariven S; Benmelha Z; Servois V; Casalino E; Bouvet E; Sibert A; Vachon F; et al; Department of Radiology, Hopital Bichat, Paris, France.; PURPOSE: To determine the predictive imaging (CT and/or MR) features of brain toxoplasmosis recurrences in acquired immunodeficiency syndrome. METHODS: The imaging studies of patients with brain toxoplasmosis were retrospectively reviewed. Forty-three patients with significant decrease or disappearance of brain lesion
Lung cancer in patients with human immunodeficiency virus infection.: Am J Clin Oncol. 1995 Feb;18(1):59-66. Unique Identifier : AIDSLINE MED/95149909; Flores MR; Sridhar KS; Thurer RJ; Saldana M; Raub WA Jr; Klimas NG; Department of Medicine, Sylvester Comprehensive Cancer Center,; University of Miami School of Medicine, FL 33101.; This retrospective study determined the clinical course of lung cancer in patients with human immunodeficiency virus (HIV) infection. A total of 23 patients with HIV infection archived as lung cancer were studied: 16 were identified from about 1,000 lung cancer patients entered in the tumor registry and medical record
Multidisciplinary HIV Conference to offer latest information in management of HIV-positive dental patients [news]: Am J Orthod Dentofacial Orthop. 1995 Feb;107(2):16A. Unique Identifier : AIDSLINE MED/95149924
CMV gastric ulcer as the presenting manifestation of AIDS.: Am J Gastroenterol. 1995 Feb;90(2):319-21. Unique Identifier : AIDSLINE MED/95149963; Vachon GC; Brown BS; Kim C; Chessin LN; Department of Medicine, Genesee Hospital, Rochester, New York.
Adult T-cell leukemia/lymphoma with two distinct clones in the peripheral blood and lymph node.: Am J Hematol. 1995 Feb;48(2):116-9. Unique Identifier : AIDSLINE MED/95149976; Shibata K; Shimamoto Y; Suga K; Watanabe M; Kikuchi M; Yamaguchi M; Department of Internal Medicine, Saga Medical School, Japan.; A case of adult T-cell leukemia/lymphoma (ATL) with two different clones in the peripheral blood and lymph nodes is reported here. When cellular DNA from the lymph node was digested with EcoRI, one band larger than 9 Kb was detected. Digestion of the cellular DNA with PstI resulted in one clear band in addition to thr
Treatment of AIDS-associated Kaposi's sarcoma with oral tretinoin.: Am J Hosp Pharm. 1994 Oct 1;51(19):2417-9. Unique Identifier : AIDSLINE MED/95150064; Bonhomme L; Fredj G; Ecstein E; Maurisson G; Farabos C; Misset JL; Jasmin C; Paul Brousse Hospital, Villejuif, France.
Cytomegalovirus esophagitis in AIDS: a prospective evaluation of clinical response to ganciclovir therapy, relapse rate, and long-term outcome.: Am J Med. 1995 Feb;98(2):169-76. Unique Identifier : AIDSLINE MED/95150089; Wilcox CM; Straub RF; Schwartz DA; Department of Medicine, Emory University School of Medicine,; Atlanta, Georgia 30303.; PURPOSE: Although cytomegalovirus ( CMV ) esophagitis is an important complication of acquired immunodeficiency syndrome, there has been little study specifically addressing the response to currently available antiviral therapy
The tolerance for zidovudine plus thrice weekly or daily trimethoprim-sulfamethoxazole with and without leucovorin for primary prophylaxis in advanced HIV disease. California Collaborative Treatment Group.: Am J Med. 1995 Feb;98(2):177-82. Unique Identifier : AIDSLINE MED/95150090; Bozzette SA; Forthal D; Sattler FR; Kemper C; Richman DD; Tilles JG; Leedom J; McCutchan JA; Department of Medicine, University of California San Diego, La; Jolla.; PURPOSE: Trimethoprim-sulfamethoxazole (TMP/SMX) is the preferred agent for prophylaxis of Pneumocystis carinii pneumonia (PCP) in patients with HIV infection, but frequent adverse events limit its usefulness. Intermittent dosing and supplementation with leucovorin have been tried in attempts to improve tolerance. We
Saliva test gets FDA approval.: Am J Nurs. 1995 Feb;95(2):12. Unique Identifier : AIDSLINE MED/95150151
Kristine Gebbie [interview by Marietta Lee]: Am J Nurs. 1995 Feb;95(2):34-7. Unique Identifier : AIDSLINE MED/95150157; Gebbie K
Invasive fetal monitoring and human immunodeficiency virus transmission [letter; comment]: Am J Obstet Gynecol. 1995 Jan;172(1 Pt 1):243-4. Unique Identifier : AIDSLINE MED/95150211; Spence MR; Harwell T
Correlates of attitudes concerning human immunodeficiency virus and acquired immunodeficiency syndrome among hospital workers.: Am J Infect Control. 1994 Oct;22(5):293-9. Unique Identifier : AIDSLINE MED/95150301; Gershon RR; Curbow B; Kelen G; Celantano D; Lears K; Vlahov D; Department of Environmental Health Sciences, School of Hygiene; and Public Health, Johns Hopkins University, Baltimore, MD 21205.; BACKGROUND: Correlates of attitudes related to HIV and AIDS for both clinical and nonclinical support hospital workers have not been well described. METHODS: A cross-sectional study was conducted among employees of an acute care, inner-city hospital to assess attitudes related to HIV and AIDS. RESULTS: A 51% response
Analysis of needlestick injuries to health care workers providing home care.: Am J Infect Control. 1994 Oct;22(5):300-6. Unique Identifier : AIDSLINE MED/95150302; Backinger CL; Koustenis GH; Division of Professional Practices, Food and Drug Administration,; Rockville, MD 20857.; BACKGROUND: This research analyzed needlestick injuries sustained by employees working in the home health environment to determine to what extent existing infection control policies and procedures in home health care are effective in reducing the risk of transmission of blood-borne infections. METHODS: In June and Jul
AIDS-related dementia and calcium homeostasis.: Ann N Y Acad Sci. 1994 Dec 15;747:205-24. Unique Identifier : AIDSLINE MED/95150339; Lipton SA; Department of Neurology, Children's Hospital, Boston,; Massachusetts.; Approximately a third of adults and half of children with acquired immunodeficiency syndrome (AIDS) eventually suffer from neurological manifestations, including dysfunction of cognition, movement, and sensation. Among the various pathologies reported in the brain of patients with AIDS is neuronal injury and loss. A p
Intestinal microsporidiosis. Report of five cases.: Ann Clin Lab Sci. 1994 Nov-Dec;24(6):521-32. Unique Identifier : AIDSLINE MED/95150449; Sun T; Kaplan MH; Teichberg S; Weissman G; Smilari T; Urmacher C; Department of Laboratories, Medicine and Pediatrics, North Shore; University Hospital, Cornell University Medical College,; Manhasset, NY 11030.; Five cases of intestinal microsporidiosis are reported, including one case of a heterosexual female acquired immunodeficiency syndrome (AIDS) patient, three homosexual males, and one bisexual male AIDS patients with detailed description of their clinical course. These
What is the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis? [editorial; comment]: Ann Neurol. 1995 Feb;37(2):143-5. Unique Identifier : AIDSLINE MED/95150532; Hollsberg P; Hafler DA
Detection of human T-lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by in situ hybridization [see comments]: Ann Neurol. 1995 Feb;37(2):167-75. Unique Identifier : AIDSLINE MED/95150535; Lehky TJ; Fox CH; Koenig S; Levin MC; Flerlage N; Izumo S; Sato E; Raine CS; Osame M; Jacobson S; Neuroimmunology Branch, National Institute of Neurological; Diseases and Stroke, National Institutes of Health, Bethesda, MD; 20892.; Autopsy specimens from 3 patients with human T-lymphotropic virus (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) were examined for the presence of HTLV-I in the central nervous system (CNS). In situ hybridization using an HTLV-I tax RNA probe detected cells containing HTLV-I RNA in spinal cord a
Inhibition of retrovirus-induced syncytium formation by photoproducts of a brominated 1,8-naphthalimide compound.: Antiviral Res. 1994 Oct;25(2):133-46. Unique Identifier : AIDSLINE MED/95150556; Chanh TC; Lewis DE; Judy MM; Sogandares-Bernal F; Michalek GR; Utecht RE; Skiles H; Chang SC; Matthews JL; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, TX 78228.; A major disadvantage of conventional phototherapy is the requirement for the in situ delivery of stimulating photoenergy subsequent to the binding of photochemicals to target malignant cells, or virus-infected cells, or viruses. This drawback has resulted in considerable limitation in the use of photochemicals in phot
Synthesis and antiviral activity of new carbonylphosphonate 2',3'-dideoxy-3'-thiacytidine conjugates.: Antiviral Res. 1994 Oct;25(2):161-8. Unique Identifier : AIDSLINE MED/95150558; Charvet AS; Turin F; Faury P; Hantz O; Camplo M; Mourier N; Berthillon P; Graciet JC; Chermann JC; Trepo C; et al; Laboratoire de Chimie Biomoleculaire, Faculte des Sciences de; Luminy, Marseille, France.; The synthesis of new potential PFA-BCH-189 conjugate analogues is described and their molecular structure clearly identified through NMR and mass spectra techniques. The anti-HIV-1 activity was determined according to the inhibition of syncytium formation in MT-4 cells, while the anti-HBV activity was determined in in
The prevention of cell adhesion and the cell-to-cell spread of HIV-1 in vitro by the alpha-glucosidase 1 inhibitor, 6-O-butanoyl castanospermine (MDL 28574).: Antiviral Res. 1994 Oct;25(2):169-75. Unique Identifier : AIDSLINE MED/95150559; Bridges CG; Brennan TM; Taylor DL; McPherson M; Tyms AS; Marion Merrell Dow Research Institute Laboratory, MRC; Collaborative Centre, London, UK.; The intercellular adhesion molecule (ICAM-1, CD54) and its counter receptor, the integrin leukocyte function associated antigen 1 (LFA-1, CD11a/CD18), have important roles in the immune response. These include guiding leukocytes to sites of inflammation (Issekutz and Issekutz, 1992), enhancement of antigen presentatio
9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system.: Antiviral Res. 1994 Oct;25(2):81-9. Unique Identifier : AIDSLINE MED/95150560; Villani N; Calio R; Balestra E; Balzarini J; De Clercq E; Fabrizi E; Perno CF; Del Gobbo V; Department of Experimental Medicine and Biochemical Sciences,; University of Rome, Tor Vergata, Italy.; PMEA (9-(2-phosphonylmethoxyethyl)adenine) is a potent inhibitor of DNA viruses and retroviruses able to enhance natural immune functions such as natural killer cell activity and interferon production. The results reported in this paper show that the treatment with PMEA significatively decreased the mortality of mice
Clinical and epidemiologic features of infection with Mycobacterium genavense. Swiss HIV Cohort Study [see comments]: Arch Intern Med. 1995 Feb 27;155(4):400-4. Unique Identifier : AIDSLINE MED/95150747; Pechere M; Opravil M; Wald A; Chave JP; Bessesen M; Sievers A; Hein R; von Overbeck J; Clark RA; Tortoli E; et al; Division of Infectious Diseases, Hopital Cantonal Universitaire,; Geneva, Switzerland.; OBJECTIVES: To characterize clinical and epidemiologic features of infections with Mycobacterium genavense. DESIGN: Case series and case-control studies. Patients with M genavense were compared with two control groups: CD4 controls were matched on the basis of CD4 counts, and Mycobacterium avium-intracellulare complex
Screening for human immunodeficiency virus antibody in urine.: Arch Pathol Lab Med. 1995 Feb;119(2):139-41. Unique Identifier : AIDSLINE MED/95150785; Berrios DC; Avins AL; Haynes-Sanstad K; Eversley R; Woods WJ; Center for AIDS Prevention Studies, San Francisco, CA 94105.; OBJECTIVE--To determine the diagnostic accuracy of an investigational test for human immunodeficiency virus (HIV) envelope antibodies in urine. DESIGN--Matched blood and urine specimens were tested for HIV by two independent laboratories, both of which were blinded to all results at the other site. Duplicate positive
Plasma cobalamin levels affect information processing speed in a longitudinal study of HIV-1 disease.: Arch Neurol. 1995 Feb;52(2):195-8. Unique Identifier : AIDSLINE MED/95150861; Shor-Posner G; Morgan R; Wilkie F; Eisdorfer C; Baum MK; Department of Epidemiology, University of Miami (Fla) School of; Medicine.; OBJECTIVE: To determine whether information processing speed is influenced by change in plasma cobalamin status in human immunodeficiency virus type 1 disease. DESIGN: A longitudinal study, using autoregression, to evaluate the relationship between plasma cobalamin status and change in information processing speed ass
HIV drug mislabelled [letter; comment]: Aust Fam Physician. 1994 Dec;23(12):2374. Unique Identifier : AIDSLINE MED/95150881; Hill P
The safety of modern contraceptives.: Aust N Z J Obstet Gynaecol. 1994 Jun;34(3):305-12. Unique Identifier : AIDSLINE MED/95150939; Rosenfield A; Broholm C; Columbia School of Public Health, Columbia Presbyterian Medical; Center, New York City.
Contraceptives of the future in the light of HIV infection.: Aust N Z J Obstet Gynaecol. 1994 Jun;34(3):330-2. Unique Identifier : AIDSLINE MED/95150943; Short RV; Department of Physiology, Monash University, Clayton, Victoria.; The AIDS and sexually transmissible disease pandemics have helped to focus the world s attention on the need for good protection against transmission of infections during sexual intercourse. Most of the highly effective modern contraceptives provide only limited protection against STD transmission, although recent pro
Identification of a substrate site for transglutaminases on the human protein synthesis initiation factor 5A.: Biochem J. 1995 Feb 1;305 ( Pt 3):725-8. Unique Identifier : AIDSLINE MED/95151003; Beninati S; Nicolini L; Jakus J; Passeggio A; Abbruzzese A; Department of Biology, II University of Rome Tor Vergata, Italy.; Protein synthesis initiation factor 5A (eIF-5A) from human erythrocytes was found to be a substrate for both plasma transglutaminase (Factor XIIIa) and guinea pig liver transglutaminase (GPLTG). When purified eIF-5A was incubated with GPLTG or Factor XIIIa in the presence of succinylated beta-casein, a covalent comple
Lack of correlation between phenotype activation markers of CD8 lymphocytes and cytotoxic T lymphocyte (CTL) function in HIV-1 infection: evidence for rescue with rIL-2.: Viral Immunol. 1994;7(2):81-95. Unique Identifier : AIDSLINE MED/95151138; Chia WK; Nisbet-Brown E; Li X; Salit I; Joshi S; Read SE; Department of Microbiology, University of Toronto, Ontario,; Canada.; CTL activity against HIV-1 antigens expressed on HLA-A-matched EBV-transformed B target cells was detected in 33% (6/18) of freshly isolated PBMC (FPBMC) from patients in the early stages of HIV-1 infection (CDCII). No CTL activity was detected in FPMBC in patients with AIDS (CDCIV). However, the presence of CTL activ
The Th1-Th2 hypothesis of HIV infection: new insights.: Immunol Today. 1994 Dec;15(12):575-81. Unique Identifier : AIDSLINE MED/95151146; Clerici M; Shearer GM; Cattedra di Immunologia, Universita degli Studi, Milano, Italy.; In their earlier, much quoted, viewpoint article, Mario Clerici and Gene Shearer examined the role of T helper 1 (Th1)- and Th2-type responses in immune dysregulation associated with human immunodeficiency virus (HIV) infection. In this article, they consider the complications of a Th1-Th2 model raised by the nomencla
Clinically significant drug interactions with antituberculosis agents.: Drug Saf. 1994 Oct;11(4):242-51. Unique Identifier : AIDSLINE MED/95151177; Grange JM; Winstanley PA; Davies PD; Department of Microbiology, National Heart and Lung Institute,; London, England.; Standard short-course regimens for tuberculosis are used worldwide with very few problems. Unfortunately, the emergence of multiple drug-resistant tuberculosis in many parts of the world is leading to a diversification of drug regimens and to the use of drugs that are more toxic per se and more likely to interact with
Effect of low dose radiation on intracellular calcium and protein kinase C in lymphocytes.: Biomed Environ Sci. 1994 Sep;7(3):284-91. Unique Identifier : AIDSLINE MED/95151191; Liu SZ; Su X; Han ZB; Zhang YC; Qi J; MPH Radiobiology Research Unit, Norman Bethune University of; Medical Sciences, Changchun, China.; It is first reported in the present paper that whole-body irradiation (WBI) with low dose X-rays could increase intracellular calcium ions ([Ca2+]i) and stimulate protein kinase C (PKC) activity of mouse lymphocytes. Following WBI of male Kunming mice with 75 mGy X-rays at a dose rate of 12.5 mGy/min the mobilization
How effective are risk-reduction interventions targeting injecting drug users? [editorial]: AIDS. 1994 Nov;8(11):1515-24. Unique Identifier : AIDSLINE MED/95151227; Booth RE; Watters JK
Cloning and biological characterization of human single-chain Fv fragments that mediate neutralization of HIV-1.: AIDS. 1994 Nov;8(11):1525-32. Unique Identifier : AIDSLINE MED/95151228; Srikantan V; Wang B; Satre MA; Ugen KE; Dang K; Scales F; Godillot AP; Williams WV; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania School of Medicine, Philadelphia 19104.; OBJECTIVE: To develop recombinant single-chain Fv fragments against HIV-1 gp120. METHODS: A panel of human monoclonal antibody Fv fragments were generated against the HIV-1 gp120 by affinity selection from an antibody library expressed on the surface of filamentous phage. The library was prepared from peripheral blood
Viro-immunological studies in acute HIV-1 infection.: AIDS. 1994 Nov;8(11):1533-8. Unique Identifier : AIDSLINE MED/95151229; Roos MT; de Leeuw NA; Claessen FA; Huisman HG; Kootstra NA; Meyaard L; Schellekens PT; Schuitemaker H; Miedema F; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam.; OBJECTIVE: To monitor a patient who presented with symptomatic HIV-1 infection for virological and immunological parameters in relation to the clinical course. METHODS: Virological studies included determination of frequency of productively HIV-1-infected peripheral blood mononuclear cells (PBMC) and viral RNA load in
Antiviral efficacy, intracellular uptake and pharmacokinetics of free and liposome-encapsulated 2',3'-dideoxyinosine.: AIDS. 1994 Nov;8(11):1545-53. Unique Identifier : AIDSLINE MED/95151231; Desormeaux A; Harvie P; Perron S; Makabi-Panzu B; Beauchamp D; Tremblay M; Poulin L; Bergeron MG; Laboratoire et Service d'Infectiologie, Centre Hospitalier de; l'Universite Laval, Quebec, Canada.; OBJECTIVE: To evaluate the effect of liposome encapsulation on the in vitro antiviral efficacy, intracellular uptake and in vivo pharmacokinetics of 2 ,3 -dideoxyinosine (ddl). METHODS: The accumulation of free and liposome-encapsulated ddl was determined in murine monocyte-macrophage RAW 264.7 cells and human premono
Octreotide therapy of large-volume refractory AIDS-associated diarrhea: a randomized controlled trial.: AIDS. 1994 Nov;8(11):1563-7. Unique Identifier : AIDSLINE MED/95151233; Garcia Compean D; Ramos Jimenez J; Guzman de la Garza F; Saenz C; Maldonado H; Barragan RF; Michel H; Department of Internal Medicine, University Hospital, Faculty of; Medicine, Autonomous University of Nuevo Leon, Monterrey, Mexico.; OBJECTIVE: To compare the effect of octreotide (a long-acting somatostatin analog) to that of antidiarrheal therapy plus placebo on large-volume refractory AIDS-associated diarrhea. DESIGN: A randomized controlled trial. SETTING: Referral-based clinic and hospital in a tertiary care center. PATIENTS: Twenty male patie
Cytokine gene expression in HIV-infected intestinal mucosa.: AIDS. 1994 Nov;8(11):1569-75. Unique Identifier : AIDSLINE MED/95151234; McGowan I; Radford-Smith G; Jewell DP; Department of Gastroenterology, Radcliffe Infirmary, Oxford, UK.; OBJECTIVE: Cytokine dysregulation has been implicated in AIDS pathogenesis and the gastrointestinal tract, containing approximately 40% of the body s lymphoid tissue, is likely to act both as a reservoir of viral infection and a site for immune dysregulation. In this study evidence of cytokine dysregulation in intesti
Predictors of disease progression in HIV-infected homosexual men with CD4+ cells < 200 x 10(6)/l but free of AIDS-defining clinical disease.: AIDS. 1994 Nov;8(11):1577-83. Unique Identifier : AIDSLINE MED/95151235; Keet IP; Krol A; Koot M; Roos MT; de Wolf F; Miedema F; Coutinho RA; Municipal Health Service, Department of Public Health and; Environment, Amsterdam, The Netherlands.; OBJECTIVE: To study progression of HIV infection in individuals who are free of AIDS-defining clinical disease with CD4+ cell counts
Incident HIV-1 infection in a cohort of young women in Butare, Rwanda.: AIDS. 1994 Nov;8(11):1585-91. Unique Identifier : AIDSLINE MED/95151236; Bulterys M; Chao A; Habimana P; Dushimimana A; Nawrocki P; Saah A; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, Maryland.; OBJECTIVE: To determine the incidence of HIV-1 infection and associated risk factors among young, seronegative, and sexually active women in a mixed rural and urban population in southern Rwanda . DESIGN: A prospective cohort study. METHODS: Between October 1991 and April 1993, we c
HIV infection among homeless adults and runaway youth, United States, 1989-1992. Field Services Branch.: AIDS. 1994 Nov;8(11):1593-8. Unique Identifier : AIDSLINE MED/95151237; Allen DM; Lehman JS; Green TA; Lindegren ML; Onorato IM; Forrester W; HIV Seroepidemiology Branch, Centers for Disease Control and; Prevention, Atlanta, GA 30333.; OBJECTIVES: Homeless persons have an increased risk of HIV infection because of a high prevalence of HIV-related risk behaviors. These include drug use, sexual contact with persons at risk for HIV infection, and the exchange of sex for drugs. The objectives of this investigation were to describe HIV seroprevalence rat
HIV testing in Switzerland.: AIDS. 1994 Nov;8(11):1599-603. Unique Identifier : AIDSLINE MED/95151238; Jeannin A; Dubois-Arber F; Paccaud F; University Institute of Social and Preventive Medicine, Lausanne,; Switzerland.; OBJECTIVES: To obtain information about the prevalence of, reasons for, and adequacy of HIV testing in the general population in Switzerland in 1992. DESIGN: Telephone survey (n = 2800). RESULTS: Some 47% of the sample underwent one HIV test performed through blood donation (2
Gonorrhea as a risk factor for HIV acquisition [see comments]: AIDS. 1994 Nov;8(11):1605-8. Unique Identifier : AIDSLINE MED/95151239; Weir SS; Feldblum PJ; Roddy RE; Zekeng L; Family Health International, Research Triangle Park, NC 27709.; OBJECTIVE: The role of gonorrhea in facilitating acquisition of HIV infection has only recently been studied. A previous nested case-control analysis in a cohort of female sex workers in Zaire found a strong association between HIV seroconversion and prior gonorrheal infection. Th
Estimating the number of HIV transmissions through reused syringes and needles in the Mbeya Region, Tanzania.: AIDS. 1994 Nov;8(11):1609-15. Unique Identifier : AIDSLINE MED/95151240; Hoelscher M; Riedner G; Hemed Y; Wagner HU; Korte R; von Sonnenburg F; Department of Infectious Diseases and Tropical Medicine,; University of Munich, Germany.; OBJECTIVE: HIV infection attributable to medical injections is suspected to be low, although case-control studies have not provided definite results. This study aims to determine the number of HIV infections caused by the reuse of syringes and needles in the Mbeya Region, Tanzania
HIV-2-infected patients survive longer than HIV-1-infected patients.: AIDS. 1994 Nov;8(11):1617-20. Unique Identifier : AIDSLINE MED/95151241; Whittle H; Morris J; Todd J; Corrah T; Sabally S; Bangali J; Ngom PT; Rolfe M; Wilkins A; Medical Research Council Laboratories, Banjul, The Gambia, West; Africa.; OBJECTIVE: To compare survival of patients infected with HIV-1 and HIV-2. DESIGN: Longitudinal follow-up of 175 HIV-1- and 294 HIV-2-infected patients identified in, or referred to a hospital in The Gambia . METHODS: Survival analysis methods were used and the death rate ratios for
CD4+ T-lymphocytopenia in HIV-infected patients receiving interferon therapy for chronic hepatitis C. HIV-Hepatitis Spanish Study Group [letter]: AIDS. 1994 Nov;8(11):1621-2. Unique Identifier : AIDSLINE MED/95151242; Soriano V; Bravo R; Samaniego JG; Gonzalez J; Odriozola PM; Arroyo E; Vicario JL; Castro A; Colmenero M; Carballo E; et al
HIV-1MN recombinant gp120 vaccine serum, which fails to neutralize primary isolates of HIV-1, does not antagonize neutralization by antibodies from infected individuals [letter]: AIDS. 1994 Nov;8(11):1622-3. Unique Identifier : AIDSLINE MED/95151243; Wrin T; Nunberg JH
Early detection of HIV-1 in men from Kenya using a synthetic peptide and a p24 antigen enzyme-linked immunosorbent assay [letter]: AIDS. 1994 Nov;8(11):1625-6. Unique Identifier : AIDSLINE MED/95151245; Tyndall MW; Gomez AM; Maitha G; Ndinya-Achola JO; MacLean I; Plummer FA; Rosenthal KL
Prevalence of HIV-1 subtype O infection in Cameroon: preliminary results [letter]: AIDS. 1994 Nov;8(11):1626-8. Unique Identifier : AIDSLINE MED/95151246; Zekeng L; Gurtler L; Afane Ze E; Sam-Abbenyi A; Mbouni-Essomba G; Mpoudi-Ngolle E; Monny-Lobe M; Tapka JB; Kaptue L
Sensitivity of screening kits for anti-HIV-1 subtype O antibodies [letter]: AIDS. 1994 Nov;8(11):1628-9. Unique Identifier : AIDSLINE MED/95151247; Simon F; Ly TD; Baillou-Beaufils A; Fauveau V; De Saint-Martin J; Loussert-Ajaka I; Chaix ML; Saragosti S; Courouce AM; Ingrand D; et al
Accuracy of exposure assessment in prospective studies of risk factors for HIV infection among intravenous drug users [letter; comment]: AIDS. 1994 Nov;8(11):1629-30. Unique Identifier : AIDSLINE MED/95151248; Nicolosi A
Reconstruction of subregional diffusion of HIV infection among injecting drug users in Southeast Asia: implications for early intervention [letter]: AIDS. 1994 Nov;8(11):1630-2. Unique Identifier : AIDSLINE MED/95151249; Stimson GV
Marked impact of the expanded AIDS case definition in Spain [letter]: AIDS. 1994 Nov;8(11):1632-3. Unique Identifier : AIDSLINE MED/95151250; Castilla J; Gutierrez A; Sanchez MF
Use of doxycycline in the management of a patient with toxoplasmic encephalitis [letter]: AIDS. 1994 Nov;8(11):1633-4. Unique Identifier : AIDSLINE MED/95151251; Indorf AS; Pegram PS
Statistics from the Centers for Disease Control and Prevention.: AIDS. 1994 Nov;8(11):1635-7. Unique Identifier : AIDSLINE MED/95151252
Notes from the ninth international conference on AIDS [news]: Asepsis. 1994 1st Quarter;16(1):22. Unique Identifier : AIDSLINE MED/95151311; Klimek JJ
Multiple metachronous skin squamous cell carcinomas and epidermodysplasia verruciformis in the head region: a human papilloma virus-associated disease.: Eur Arch Otorhinolaryngol. 1994;251(6):342-6. Unique Identifier : AIDSLINE MED/95151323; Weber BP; Fierlbeck G; Kempf HG; Department of Otorhinolaryngology, Medizinische Hochschule; Hannover, Germany.; Data from a young adult man with epidermodysplasia verruciformis (EV) and multiple metachronous spinaliomas in the head and neck region are presented. Diagnosis of this rare, human papilloma virus (HPV)-associated disease was based on: (1) Typical skin lesions, including viral warts, verruca plana-type lesions and pit
Absence of HIV-1 DNA in cartilage from HIV-positive patients.: Eur Arch Otorhinolaryngol. 1994;251(6):347-9. Unique Identifier : AIDSLINE MED/95151324; Bujia J; Zietz C; Randolph P; Wilmes E; Gurtler L; Department of Otorhinolaryngology, Klinikum Grosshadern, Munich,; Germany.; Human immunodeficiency virus (HIV) infections are mainly transferred by blood, semen or organ transplantations. Since allogenic transplants have an established place in reconstructive surgery, the possibility of transferring HIV with such transplants has been a subject of much concern. Postmortem cartilage samples wer
Use of preventive interventions by persons infected with type-1 human immunodeficiency virus (HIV-1). The Pulmonary Complications of HIV Study Group.: Am J Prev Med. 1994 Sep-Oct;10(5):259-66. Unique Identifier : AIDSLINE MED/95151347; Glassroth J; Jordan M; Wallace JM; Kvale PA; Follmann DA; Rosen MJ; Reichman LB; Mossar M; Hopewell PC; Division of Pulmonary Medicine, Northwestern University Medical; School, Chicago, IL.; Measures aimed at preventing complications and slowing progression of type-1 human immunodeficiency virus (HIV-1) can potentially reduce morbidity. Although little is known about the use of such measures, such data are critical for program planning. This study was performed to quantify the frequency and patterns of us
Tenth anniversary perspectives on AIDS. Host-HTLV type I interaction at the molecular level.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1193-7. Unique Identifier : AIDSLINE MED/95151355; Yoshida M; Department of Cellular and Molecular Biology, Institute of; Medical Science, University of Tokyo, Japan.
Interleukin 10 blocks HIV replication in macrophages by inhibiting the autocrine loop of tumor necrosis factor alpha and interleukin 6 induction of virus.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1199-206. Unique Identifier : AIDSLINE MED/95151356; Weissman D; Poli G; Fauci AS; Laboratory of Immunoregulation, National Institutes of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892.; Human interleukin 10 is a pleiotropic cytokine capable of suppressing cytokine production from macrophages and T cells; in addition, it exerts complex regulatory effects on CD8+ T cells, natural killer cells, vascular endothelial cells, and B lymphocytes. Levels of IL-10 are elevated in HIV-infected individuals, sugge
Stimulation of HIV type 1 gene expression and induction of NF-kappa B (p50/p65)-binding activity in tumor necrosis factor alpha-treated human fetal glial cells.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1207-11. Unique Identifier : AIDSLINE MED/95151357; Atwood WJ; Tornatore CS; Traub R; Conant K; Drew PD; Major EO; Laboratory of Molecular Medicine and Neuroscience, National; Institute of Neurological Disorders and Stroke, Bethesda,; Maryland 20892.; In vitro, HIV-1 infection of human fetal glial cells initiates a noncytopathic, productive infection that results in a long-term persistence during which the viral genome remains latent. The cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) reactivate HIV-1 gene expression in these c
Association of alterations in NF-kappa B moieties with HIV type 1 proviral latency in certain monocytic cells.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1213-9. Unique Identifier : AIDSLINE MED/95151358; Oakes JW; Bagasra O; Duan L; Pomerantz RJ; Department of Medicine, Dorrance H. Hamilton Laboratories,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania 19104.; Human immunodeficiency virus type 1 (HIV-1) replication is controlled by a complex array of virally encoded and cellular proteins. A wide spectrum of levels of HIV-1 expression have been demonstrated in various cells, both in cell culture and in vivo. Molecular mechanisms leading to restricted HIV-1 replication may di
HIV type 1 induction of interleukin 1 and 6 production by human thymic cells.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1221-9. Unique Identifier : AIDSLINE MED/95151359; Sandborg CI; Imfeld KL; Zaldivar F Jr; Berman MA; Department of Medicine, University of California at Irvine 92717.; In vitro and in vivo studies have demonstrated that HIV can infect thymocytes at different maturational stages and lead to changes in the thymic microenvironment. To determine the effect of HIV on thymic stromal cells and the production of cytokines important in thymocyte development, three types of adherent thymic cu
Fusogenic activity of amino-terminal region of HIV type 1 Nef protein.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1231-40. Unique Identifier : AIDSLINE MED/95151360; Curtain CC; Separovic F; Rivett D; Kirkpatrick A; Waring AJ; Gordon LM; Azad AA; Biomolecular Research Institute, Parkville, Victoria, Australia.; We have studied two isoforms of Nef, Nef-27 and Nef-25, which were produced in E. coli. Nef-25 lacked the first 18 N-terminal residues of Nef-27 and both were nonmyristylated. Nef-27 fuses small unilamellar dipalmitoyl phosphatidylcholine vesicles (SUVs), as indicated by enhanced light scattering of SUVs and lipid mix
Viral DNA burden and decline in percentage of CD4-positive cells in the lymphoid compartment of SIV-infected macaques.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1269-77. Unique Identifier : AIDSLINE MED/95151364; Rosenberg YJ; Lewis MG; Leon EC; Cafaro A; Eddy GA; Greenhouse JJ; Henry M. Jackson Foundation Laboratories, Rockville, Maryland; 20850.; The decline in CD4+ cells and increased viral DNA and RNA burden in the blood of human immunodeficiency virus (HIV)-infected individuals have been used as closely related correlates of disease progression. However, little is known about levels of total or unintegrated viral DNA in lymphoid tissue of HIV-infected patie
An animal model for antilentiviral therapy: effect of zidovudine on viral load during acute infection after exposure of macaques to simian immunodeficiency virus.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1279-87. Unique Identifier : AIDSLINE MED/95151365; Le Grand R; Clayette P; Noack O; Vaslin B; Theodoro F; Michel G; Roques P; Dormont D; Laboratoire de Neuropathologie Experimentale et Neurovirologie,; Centre de Recherches du Service de Sante des Armees,; Fontenay-aux-Roses, France.; We analyzed the kinetics of the virological and immunological events that occurred in four AZT-treated cynomolgus macaques during the acute infection that followed their exposure to the simian immunodeficiency virus (SIVmac251) grown on monkey PBMCs in a cell-free stock solution. These events included changes in the C
Isolation of simian immunodeficiency viruses from two sooty mangabeys in Cote d'Ivoire: virological and genetic characterization and relationship to other HIV type 2 and SIVsm/mac strains.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1289-94. Unique Identifier : AIDSLINE GENBANK/X78511; Peeters M; Janssens W; Fransen K; Brandful J; Heyndrickx L; Koffi K; Delaporte E; Piot P; Gershy-Damet GM; van der Groen G; Department of Infection and Immunity, Institute of Tropical; Medicine, Antwerp, Belgium.; OBJECTIVE: To search for the presence of SIV in sooty mangabeys and other monkey species in Cote d Ivoire , West Africa, and to compare viral isolates with HIV-2 strains from the same region. METHODS: Forty-three captive housed monkeys (28 African green monkeys, 6 sooty mangabe
Fine analysis of humoral antibody response to envelope glycoprotein of SIV in infected and vaccinated macaques.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1295-304. Unique Identifier : AIDSLINE MED/95151367; Silvera P; Flanagan B; Kent K; Rud E; Powell C; Corcoran T; Bruck C; Thiriart C; Haigwood NL; Stott EJ; National Institute for Biological Standards and Control, Potters; Bar, Hertfordshire, United Kingdom.; To characterize the serological response to SIV envelope, induced by vaccination with different envelope immunogens or by SIV infection, plasma samples from 11 cynomolgus macaques infected with simian immunodeficiency virus (SIV) and from 16 macaques vaccinated with three different recombinant envelope proteins were a
Mechanisms of HIV/SIV mucosal transmission.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1305-12. Unique Identifier : AIDSLINE MED/95151368; Milman G; Sharma O; Division of AIDS, National Institute of Allergy and Infectious; Disease, National Institutes of Health, Bethesda, Maryland 20892.; The Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID), organized a Workshop on HIV/SIV Pathogenesis and Mucosal Transmission on March 14-17, 1994, attended by over 300 participants. The purpose of the workshop was to foster research in the areas of HIV pathogenesis, mucosal transm
Long terminal repeat sequence analysis of HTLV type I molecular variants identified in four north African patients.: AIDS Res Hum Retroviruses. 1994 Oct;10(10):1313-5. Unique Identifier : AIDSLINE GENBANK/U12807; Gasmi M; Farouqi B; d'Incan M; Desgranges C; INSERM U271, Lyon, France.
[Immune evaluations in cancer patients after colorectal resection]: G Chir. 1994 Oct;15(10):429-32. Unique Identifier : AIDSLINE MED/95151476; Losacco T; De Leo G; Punzo C; Pellegrino NM; Neri V; D'Eredita G; Di Ciaula G; Pitzalis MV; Istituto di Semeiotica Chirurgica, Universita degli Studi di; Bari.; The authors report a protocol of immunomodulation and monitoring of the intestinal function in coloresected patients using fermented milk (yoghurt). Intestinal immunity was evaluated with respect to CD4+ cells armed with secretory intestine-derived IgA, and to CD8+ cells armed with IgG aiming to an additional effect i
Infectious syphilis.: Semin Dermatol. 1994 Dec;13(4):234-42. Unique Identifier : AIDSLINE MED/95151524; Sanchez MR; Department of Dermatology, New York University Medical Center,; New York 10016.; Optimistic predictions about the extinction of syphilis have proven to be premature. During the beginning of the decade, the reported numbers of infectious syphilis cases were the highest in 40 years. Despite numerous publications about syphilis, the disease continues to challenge clinicians with its protean cutaneous
Management of genital herpes infection.: Semin Dermatol. 1994 Dec;13(4):248-55. Unique Identifier : AIDSLINE MED/95151526; Lavoie SR; Kaplowitz LG; Division of Infectious Diseases, Medical College of; Virginia/Virginia Commonwealth University, Richmond 23298-0049.; Genital herpes infections are a major source of morbidity. These infections are responsible for significant health problems, including direct physical discomfort associated with outbreaks, potential complications such as neonatal transmission, and the often devastating psychological effects of a chronic illness. In ad
The 1993 sexually transmitted disease treatment guidelines.: Semin Dermatol. 1994 Dec;13(4):269-74. Unique Identifier : AIDSLINE MED/95151529; Buntin DM; Department of Medicine (Dermatology), Vanderbilt University; Medical Center, Nashville, TN.; This article will review the 1993 STD Treatment Guidelines of particular importance to dermatologic clinical practice. Topics include STD/HIV prevention, management of sexual partners, STD in persons with HIV co-infection, genital ulcer disease (GUD) including syphilis, herpes simplex virus (HSV) infection, lymphogran
Cutaneous clues to HIV infection: diagnosis and treatment.: Semin Dermatol. 1994 Dec;13(4):275-85. Unique Identifier : AIDSLINE MED/95151530; Cockerell CJ; Division of Dermatopathology, University of Texas Southwestern; Medical Center, Dallas 75235-7200.; The skin is one of the most important organs involved in patients with HIV infection. Because it is the one most readily evaluated by inspection, it is essential that clinicians be expert in the recognition of skin disorders that herald the presence of HIV disease or a change in the immune status of one already known
The politics of acquired immune deficiency syndrome/human immunodeficiency virus.: Semin Dermatol. 1994 Dec;13(4):286-90. Unique Identifier : AIDSLINE MED/95151531; Felman YM; State University of New York, Health Sciences Center, Brooklyn.; The political process is a decisive factor in determining how governmental funds are allocated for control of all diseases especially one as highly politicized as AIDS/HIV. This article discusses how this process works and how various community groups such as homosexual men, women, African-Americans, and the elderly a
Detection of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in donor eyes using polymerase chain reaction.: Br J Ophthalmol. 1994 Nov;78(11):859-62. Unique Identifier : AIDSLINE MED/95151706; Shimazaki J; Tsubota K; Sawa M; Kinoshita S; Ohkura T; Honda M; Department of Ophthalmology, Tokyo Dental College, Chiba, Japan.; Detection of human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) in donor eyes was performed. DNAs were extracted from the uvea, and they were amplified using the polymerase chain reaction (PCR). Amplified viral DNAs were detected with liquid hybridisation and chemiluminescent assa
Complete inactivation of target mRNA by biotinylated antisense oligodeoxynucleotide-avidin conjugates.: Bioconjug Chem. 1994 Sep-Oct;5(5):406-10. Unique Identifier : AIDSLINE MED/95151809; Boado RJ; Pardridge WM; Department of Medicine, UCLA School of Medicine 90024.; Biotinylation of phosphodiester oligodeoxynucleotides (PO-ODN) allows for conjugation to avidin-based transcellular delivery systems. In addition, biotinylation of PO-ODN at the 3 -terminus provides complete protection against serum 3 -exonuclease degradation. The present study was undertaken to determine if antisense
Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a.: Hum Gene Ther. 1994 Oct;5(10):1217-29. Unique Identifier : AIDSLINE MED/95151837; Engelhardt JF; Litzky L; Wilson JM; Institute for Human Gene Therapy, University of Pennsylvania; Medical Center, Philadelphia 19104-4268.; Recombinant adenoviruses have tremendous potential for gene therapy of cystic fibrosis (CF) lung disease. First-generation recombinant viruses, rendered replication defective by deleting E1, have been associated with high-level recombinant gene expression in airway epithelial cells when administered directly to the lu
Gynaecological disorders and human immunodeficiency virus infection [editorial]: Int J STD AIDS. 1994 Nov-Dec;5(6):383-6. Unique Identifier : AIDSLINE MED/95151858; Shah PN; Kell PD; Barton SE; It is increasingly apparent that the differences in the prevalence and severity of various gynaecological conditions are a function of immunosuppression and differences in behavioural factors, rather than a direct effect of HIV itself. Women infected with HIV will present with their gynaecological disorders initially
Quality of care in genitourinary medicine [editorial]: Int J STD AIDS. 1994 Nov-Dec;5(6):387-9. Unique Identifier : AIDSLINE MED/95151859; de Ruiter A; Bingham JS
Problems with non-gonococcal urethritis [editorial]: Int J STD AIDS. 1994 Nov-Dec;5(6):390-9. Unique Identifier : AIDSLINE MED/95151860; Shahmanesh M
Why do antenatal attenders decide to have the HIV antibody test? [see comments]: Int J STD AIDS. 1994 Nov-Dec;5(6):400-4. Unique Identifier : AIDSLINE MED/95151861; Meadows J; Catalan J; Psychological Medicine Unit, Charing Cross and Westminster; Medical School, Chelsea.; The aim of the study was to investigate factors influencing the parturient woman s decision to accept or decline the HIV antibody test in the antenatal clinic. Eighty-eight women attending an antenatal clinic, in a central London hospital, for an appointment at 28-32 weeks of pregnancy were given a structured face to
Bacterial vaginosis in a district genitourinary medicine department: significance of vaginal microbiology and anaerobes.: Int J STD AIDS. 1994 Nov-Dec;5(6):405-8. Unique Identifier : AIDSLINE MED/95151862; Saidi SA; Mandal D; Curless E; Department of Genito-urinary Medicine, Bolton General Hospital,; Lancs, UK.; The aim of this study was to correlate the significance of vaginal microbiology, in particular its anaerobic component, to the presence of bacterial vaginosis (BV), and to review the clinical criteria used in the diagnosis of this condition. Ninety-two female patients who received routine STD screening were studied. A
A preliminary evaluation of a prototype western blot confirmatory test kit for syphilis.: Int J STD AIDS. 1994 Nov-Dec;5(6):409-14. Unique Identifier : AIDSLINE MED/95151863; Young H; Walker PJ; Merry D; Mifsud A; Department of Medical Microbiology, Edinburgh University Medical; School, Scotland.; A prototype Western blot kit was evaluated as a confirmatory test for syphilis using 131 sera characterized by other serological tests for syphilis. There were 114 treponemal sera (including 94 cases of early syphilis, 83 of which were untreated) and 17 non-treponemal problem sera (11 gave false positive reactions on
High cumulative incidence of genital herpes amongst HIV-1 seropositive heterosexuals in south London.: Int J STD AIDS. 1994 Nov-Dec;5(6):415-8. Unique Identifier : AIDSLINE MED/95151864; O'Farrell N; Tovey SJ; Lloyd Clinic, Guy's Hospital, London, UK.; The cumulative incidence of sexually transmitted diseases (STD) in a cohort of 51 (35 female, 16 male) HIV-1 seropositive STD clinic attenders who had acquired HIV-1 infection via heterosexual transmission was investigated through a retrospective review of the case notes. The women were followed up for a mean 11.6 mon
A comparison of AIDS-defining events and subsequent CDC stage IV events in IDUs and gay men.: Int J STD AIDS. 1994 Nov-Dec;5(6):419-23. Unique Identifier : AIDSLINE MED/95151865; Ross JD; Brettle R; Zhu C; Haydon G; Elton RA; Dept. of Genitourinary Medicine, Edinburgh Royal Infirmary, UK.; The two major risk groups for acquisition of HIV in the UK are gay men and IDUs. Individuals from these risk groups vary in a number of respects in their life-style, which have the potential to affect the course of their HIV disease. This study compares gay men and IDUs from the Lothian Region of Scotland with respect
Prevalence and incidence of syphilis and its association with HIV-1 infection in a population-based study in the Kagera region of Tanzania.: Int J STD AIDS. 1994 Nov-Dec;5(6):424-31. Unique Identifier : AIDSLINE MED/95151866; Killewo JZ; Sandstrom A; Bredberg Raden U; Mhalu FS; Biberfeld G; Wall S; Department of Epidemiology and Biostatistics, Muhimbili; University College of Health Sciences, Dar es Salaam, Tanzania.; Population-based prevalence and incidence studies on HIV-1 infection were started in the Kagera region of Tanzania in 1987. The prevalence and incidence of infection with Treponema pallidum was studied to enable development of better strategies for STD control. Serological diagno
Screening for tuberculosis in an east London HIV clinic.: Int J STD AIDS. 1994 Nov-Dec;5(6):432-5. Unique Identifier : AIDSLINE MED/95151867; Theodore CM; Forster GE; Goh BT; Barnes N; Hughes D; Department of Genitourinary Medicine, Royal London Hospital, UK.; A prospective study was carried out to assess the value of routine skin tuberculin testing and chest radiography in HIV seropositive patients, attending the Genitourinary Medicine (GUM) clinic between July 1991-May 1992. 144 consecutive HIV seropositive patients had tuberculin Tine tests and chest radiographs performe
Concomitant HIV and mycobacterial infection in Ireland, 1987-92.: Int J STD AIDS. 1994 Nov-Dec;5(6):436-41. Unique Identifier : AIDSLINE MED/95151868; Mundy LM; Lynch MM; Crowley BD; Kelly G; Desmond NM; Mulcahy FM; Department of Genitourinary Medicine, St James's Hospital,; Dublin, Ireland.; A six-year retrospective review of concomitant HIV and mycobacterial infection in the Republic of Ireland is presented. A total of 42 culture proven mycobacterial infections were seen in 40 different HIV-infected patients. There wer
Screening for cervical abnormalities in women with anogenital warts in an STD clinic: an inappropriate use of colposcopy.: Int J STD AIDS. 1994 Nov-Dec;5(6):442-4. Unique Identifier : AIDSLINE MED/95151869; Coker R; Desmond N; Tomlinson D; Bretherton K; Byrne M; Department of Genitourinary Medicine, Patrick Clements Clinic,; Central Middlesex Hospital, London, UK.; An audit of the use of colposcopy in women with anogenital warts was performed. Fifty women attending a clinic for sexually transmitted diseases in a District General Hospital with anogenital warts were examined by cervical cytology and colposcopy for cervical infection by human papillomavirus (HPV) or epithelial abno
Sentinel surveillance of HIV-1 infection in Tamilnadu, India.: Int J STD AIDS. 1994 Nov-Dec;5(6):445-6. Unique Identifier : AIDSLINE MED/95151870; Solomon S; Anuradha S; Ganapathy M; Jagadeeswari; AIDS Research Cell, Madras Medical College, India.; The objective was to determine the time trends in the prevalence of HIV infection and to evaluate appropriate preventive intervention in different population groups. Sentinel surveillance of HIV-1 infection by anonymous unlinked technique was carried out in Tamilnadu from December 1989 to March 1993. The sentinel popu
Transmission of trichuriasis in a sexual setting?: Int J STD AIDS. 1994 Nov-Dec;5(6):447-9. Unique Identifier : AIDSLINE MED/95151871; Melville RL; Department of Sexual Health, Whipps Cross Hospital, Leytonstone,; London, UK.
Feedback on the Tenth International Conference on AIDS/International Conference on STD (7-11 August 1994).: Int J STD AIDS. 1994 Nov-Dec;5(6):450-5. Unique Identifier : AIDSLINE MED/95151872; Patel R; Radcliffe KW; Rogstad KE; Southampton University Hospitals Trust, UK.
Communication with general practitioners by hospital-based HIV units [letter]: Int J STD AIDS. 1994 Nov-Dec;5(6):458-9. Unique Identifier : AIDSLINE MED/95151873; Guthrie B; Stinton F; Barton S; Nelson M
[Admission to a ward for terminal care as a status passage]: Pflege. 1994 Dec;7(4):272-9. Unique Identifier : AIDSLINE MED/95151952; Spirig R; In the last few years clinics exclusively for patients suffering from AIDS have been developed in Switzerland , specialising in terminal care. The institution in which the research here reported was carried out, admitted drug-dependent patients with AIDS. Admission to the unit,
A pharmacokinetic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs [published erratum appears in Biopharm Drug Dispos 1995 Mar;16(2):ii]: Biopharm Drug Dispos. 1994 Oct;15(7):535-44. Unique Identifier : AIDSLINE MED/95151981; Wong YN; Burcham DL; Saxton PL; Erickson-Viitanen S; Grubb MF; Quon CY; Huang SM; Drug Metabolism and Pharmacokinetics Section, DuPont Merck; Pharmaceutical Company, Newark, DE 19714.; The pharmacokinetics of a series of novel cyclic, non-peptide inhibitors of HIV protease were studied in rats or dogs after intravenous and oral administration. Six symmetrically substituted cyclic urea compounds (XK234, XM311, XM320, XM321, XM323, and XM412), which effectively inhibited HIV virus replication, with IC
Plasma pharmacokinetics and urinary and biliary excretion of a new potent tripeptide HIV-1 protease inhibitor, KNI-272, in rats after intravenous administration.: Biopharm Drug Dispos. 1994 Oct;15(7):617-26. Unique Identifier : AIDSLINE MED/95151988; Kiriyama A; Fujita K; Takemura S; Kuramoto H; Kiso Y; Takada K; Department of Pharmaceutics and Pharmacokinetics, Kyoto; Pharmaceutical University, Japan.; The pharmacokinetic (PK) characteristics of KNI-272, a potent and selective HIV-1 protease inhibitor, were evaluated in rats after intravenous (IV) administration. The effect of dose on KNI-272 plasma kinetics, and the urinary and biliary elimination kinetics of KNI-272, were examined. After IV administration of 10.0
Ultrastructural correlation between follicular dendritic cells and the frequency of virus-like particles during the lymph nodes reaction of SIV/HIV 2 infected cynomolgus monkeys.: Rom J Morphol Embryol. 1993 Jul-Dec;39(3-4):99-105. Unique Identifier : AIDSLINE MED/95152040; Mandache E; Biberfeld P; V. Babes Institute, Bucharest, Romania.; Lymph nodes from 18 SIV/HIV2 infected monkeys developing a severe AIDS-like disease were studied by electron microscopy. The lesions were correlated with the histopathologic staining and the anti-SIVp28 immunostaining. The investigation of follicular dendritic cells (FDC) and associated retroviral particles was focuse
Marrow accessory cell infection and alterations in hematopoiesis accompany severe neutropenia during experimental acute infection with feline immunodeficiency virus.: Blood. 1995 Feb 15;85(4):941-51. Unique Identifier : AIDSLINE MED/95152072; Linenberger ML; Beebe AM; Pedersen NC; Abkowitz JL; Dandekar S; Department of Medicine, University of Washington Seattle 98195.; Severe neutropenia and bone marrow (BM) morphologic abnormalities occur during experimentally induced primary infection with feline immunodeficiency virus (FIV), a lentivirus biologically similar to human immunodeficiency virus (HIV). To further characterize the mechanisms involved in this acute infection model of len
Rifabutin: a review with emphasis on its role in the prevention of disseminated Mycobacterium avium complex infection.: Ann Pharmacother. 1994 Nov;28(11):1250-4. Unique Identifier : AIDSLINE MED/95152108; Maddix DS; Tallian KB; Mead PS; Pharmacy Service (119), VA Medical Center, San Francisco, CA; 94121.; OBJECTIVE: To discuss the mechanism of action, in vitro and in vivo activity, pharmacokinetics, clinical trials, adverse effects, drug interactions, and dosage guidelines of rifabutin. DATA SOURCES: Pertinent literature published between 1982 and 1993 was identified via a MEDLINE search. Published proceedings of selec
New macrolide antibiotics: usefulness in infections caused by mycobacteria other than Mycobacterium tuberculosis.: Ann Pharmacother. 1994 Nov;28(11):1255-63. Unique Identifier : AIDSLINE MED/95152109; Rapp RP; McCraney SA; Goodman NL; Shaddick DJ; Division of Pharmacy Practice and Science, College of Pharmacy,; University of Kentucky, Chandler Medical Center, Lexington 40536.; OBJECTIVE: To compare the pharmacology, in vitro activity, and clinical use of the new macrolide antibiotics, azithromycin and clarithromycin, in the treatment of infections caused by mycobacteria other than Mycobacterium tuberculosis. DATA IDENTIFICATION: An English-language literature search using MEDLINE (1987-1994
Amphotericin B for visceral leishmaniasis resistant to pentavalent antimonial drugs in AIDS [letter]: Ann Pharmacother. 1994 Nov;28(11):1305. Unique Identifier : AIDSLINE MED/95152120; Rodilla F; Magraner J; Aznar J; Orovitg F; Alcacer F; Colomina J; Ferriols F
Postpartum exacerbation of HTLV-I associated myelopathy/tropical spastic paraparesis followed by an episode of painless thyroiditis.: Intern Med. 1994 Nov;33(11):703-5. Unique Identifier : AIDSLINE MED/95152156; Mizokami T; Okamura K; Sato K; Kuroda T; Itoyama Y; Fujishima M; Second Department of Internal Medicine, Faculty of Medicine,; Kyushu University, Fukuoka.; A 28-year-old woman noticed a progressive gait disturbance after her first delivery. At the age of 32, the gait disturbance improved during her second pregnancy, but became worse after delivery and eventually resulted in a scissoring gait. At the age of 34, she became transiently thyrotoxic and was diagnosed as having
T cell abnormalities in mixed connective tissue disease complicated with Klinefelter's syndrome.: Intern Med. 1994 Nov;33(11):714-7. Unique Identifier : AIDSLINE MED/95152159; Ishihara K; Yoshimura M; Nakao H; Kanakura Y; Kanayama Y; Matsuzawa Y; Second Department of Internal Medicine, Osaka University Medical; School, Suita.; We report a 28-year-old Japanese with Klinefelter s syndrome who developed mixed connective disease (MCTD) and Sjogren syndrome. Previously being well, he presented with Raynaud s phenomenon, dry eye, fever and polyarthralgia. Clinical examinations revealed anti-nRNP autoantibody, leukopenia and lung fibrosis. Then he
[Anticardiolipin antibodies in vascular occlusions of the eye]: Ophthalmologe. 1994 Dec;91(6):768-71. Unique Identifier : AIDSLINE MED/95152201; Bertram B; Haase G; Remky A; Reim M; Augenklinik, RWTH Aachen.; Elevated levels of anticardiolipin antibodies (ACA) have recently been found to be associated with occlusive diseases such as myocardial or cerebral infarction or venous thrombosis. In a prospective study anticardiolipin antibodies (both IgG and IgM) were measured by ELISA in 140 patients with acute vascular occlusion
[Changes in the immune status in patients with basal cell carcinoma of the eyelids of various TNM stages]: Ophthalmologe. 1994 Dec;91(6):820-3. Unique Identifier : AIDSLINE MED/95152210; Sivkova N; Grigorov L; Kreissig I; Universitats-Augenklinik, Medizinische Universitat Plovdiv.; Various lymphocyte populations/subpopulations--Leu-4+ (CD3+), Leu-2+ (CD8+), CD4+/CD8+ ratio, Leu-14+ (CD22+), Leu-M5+ and HLA-DR+--were studied in 104 patients with basal cell carcinoma (BCC) of the eyelid in different TNM stages by Coulter EPICS flow cytometry preoperatively. For comparison, an age-matched control g
Reduction in replication of the human immunodeficiency virus type 1 in human T cell lines by polymerase III-driven transcription of chimeric tRNA-antisense RNA genes.: Antisense Res Dev. 1994 Fall;4(3):165-72. Unique Identifier : AIDSLINE MED/95152262; Junker U; Rittner K; Homann M; Bevec D; Bohnlein E; Sczakiel G; VIRCC-LSGT, Wien, Austria.; Inhibition of human immunodeficiency virus type 1 (HIV-1) replication was demonstrated by using tat- and rev-directed antisense oligoribonucleotides 68 and 69 nucleotides in length. In this study, human T-lymphoid cells were transduced with a murine amphotropic retroviral vector containing a polymerase III-driven chim
Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey.: Antisense Res Dev. 1994 Fall;4(3):201-6. Unique Identifier : AIDSLINE MED/95152265; Galbraith WM; Hobson WC; Giclas PC; Schechter PJ; Agrawal S; APD Company, Arlington, Virginia 22209.; Rapid intravenous infusion of GEM 91, a 25-mer phosphorothioate oligonucleotide complementary to the gag site of HIV, in the monkey produces transient decreases in peripheral total WBC and neutrophil counts, hemoconcentration, and a brief increase followed by a prolonged decrease in arterial blood pressure. These chan
Intracellular susceptibility to ribozymes in a tethered substrate-ribozyme provirus model is not predicted by secondary structures of human immunodeficiency virus type 1 RNAs in vitro.: Antisense Res Dev. 1994 Fall;4(3):217-21. Unique Identifier : AIDSLINE MED/95152268; Dropulic B; Jeang KT; Molecular Virology Section, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892.; We have assessed the sensitivity of different sites in HIV-1 genomic RNA to ribozymes. Ribozymes targeted to sequences in U5, Pol, Env, RRE, or R were positioned into nef of an infectious HIV-1 provirus. When these proviral DNAs were introduced into HeLa CD4+ cells, recombinant viruses that contain ribozymes tethered
Antibiotic drug allergy in children.: Curr Opin Pediatr. 1994 Dec;6(6):656-60. Unique Identifier : AIDSLINE MED/95152641; Anderson JA; Henry Ford Hospital, Department of Pediatrics, Detroit, MI; 48202-2689.; Cutaneous reactions to penicillin-type antibiotics are usually caused by IgE-mediated reactions directed toward the beta-lactam ring (in penicillin, ampicillin-amoxicillin, and cephalosporins). These allergic reactions may be reliably diagnosed (96% to 99% of the time) with a battery of skin tests derived from penicil
Office laboratory procedures, economics of practice, patient and parent education, and urinary tract infection.: Curr Opin Pediatr. 1994 Dec;6(6):717-28. Unique Identifier : AIDSLINE MED/95152652; Ey JL; Aldous MB; Duncan B; Williams RL; University of Arizona College of Medicine, Department of; Pediatrics, Tucson 85724.; This review highlights recent advances in four major areas that are relevant to office practice: office laboratory procedures, economics of practice, adolescent risk-taking behavior in terms of sexually transmitted diseases, and urinary tract infections. Who should be screened for diseases and where these screening te
[Cancer and AIDS. Promoting communication]: Infirm Que. 1995 Jan-Feb;2(3):28-9. Unique Identifier : AIDSLINE MED/95152663; Tremblay N
Creativity and caring, hand and hearts....: Aust Nurs J. 1994 Jul;2(1):22-5. Unique Identifier : AIDSLINE MED/95152822; Fabb L
Responses of lymphocytes to Epstein-Barr virus in patients with primary immunodeficiencies.: J Investig Allergol Clin Immunol. 1994 Jul-Aug;4(4):182-4. Unique Identifier : AIDSLINE MED/95152872; Kondo N; Inoue R; Orii T; Department of Pediatrics, Gifu University School of Medicine,; Japan.; Several reports have demonstrated that the responses of B-cells to Epstein-Barr virus (EBV) are variable in common variable immunodeficiency (CVID). In this study in patients with selected primary immunodeficiencies, i.e., Bloom s syndrome, Wiskott-Aldrich syndrome or IgA deficiency, the responses of peripheral blood
Emergency abdominal operations in the patient with acquired immunodeficiency syndrome.: J Am Coll Surg. 1995 Feb;180(2):205-9. Unique Identifier : AIDSLINE MED/95152897; Bizer LS; Pettorino R; Ashikari A; Department of Surgery, Montefiore Medical Center, Bronx, NY.; BACKGROUND: We have previously shown high morbidity and mortality rates in patients with acquired immunodeficiency syndrome (AIDS) who require emergency abdominal operations. In a larger series of patients, we have investigated the reasons for these findings and have hypothesized that they are primarily the result of
[Sexuality at the hospital]: Soins Form Pedagog Encadr. 1994 TRIMESTER 4;(12):15-7. Unique Identifier : AIDSLINE MED/95152922; Guimelchain-Bonnet M
We're staying in the kitchen! [editorial]: Revolution. 1994 Summer;4(2):6-7. Unique Identifier : AIDSLINE MED/95152946; Vonfrolio LG; Swirsky J
Cardiovascular complications of AIDS.: Heart Dis Stroke. 1994 Nov-Dec;3(6):388-94. Unique Identifier : AIDSLINE MED/95153006; Ferguson DW; Volpp BD; Cardiovascular Disease Division, National Naval Medical Center,; Bethesda, MD 20889-5600.
[Leishmaniasis and AIDS]: Sante. 1994 Nov-Dec;4(6):442. Unique Identifier : AIDSLINE MED/95153040; Robert F
Drug resistance in viruses.: Trends Microbiol. 1994 Oct;2(10):401-7. Unique Identifier : AIDSLINE MED/95153053; Richman DD; University of California San Diego, Dept of Pathology, La Jolla; 92093-0679.; The mechanisms of action of antiviral drugs and of drug resistance are known in remarkable detail, partly because X-ray crystallographic structures are known for many target viral proteins. Resistance usually involves amino acid substitutions in the target protein that prevent drug binding or prevent an enzyme from ac
Cytokine receptor alterations during HIV infection in the human central nervous system.: Brain Res. 1994 Nov 7;663(1):1-6. Unique Identifier : AIDSLINE MED/95153314; Masliah E; Ge N; Achim CL; Wiley CA; University of California, San Diego, Department of Neurosciences,; La Jolla 92093-0624.; Cytokines are potent factors mediating interactions between the immune and nervous systems. Cytokines released by macrophages/microglia, the predominant immune cell within the brain, have been proposed to modulate neuronal survival and death. In human immunodeficiency virus-encephalitis (HIVE), cytokines could modulat
The right to know and the right to privacy: confidentiality, HIV and health care professionals.: Nurs Ethics. 1994 Jun;1(2):111-5. Unique Identifier : AIDSLINE MED/95153360; Dickenson D
HIV and AIDS: the nursing response and some ethical challenges.: Nurs Ethics. 1994 Dec;1(4):224-32. Unique Identifier : AIDSLINE MED/95153373; McHaffie HE; AIDS has challenged many concepts and practices within nursing. Because of the serious implications attending a positive diagnosis, and because patients with AIDS have become articulate and well informed, familiar principles have been exposed to renewed scrutiny. Anomalies and dilemmas have been revealed. Results from
Information needs of health care professionals in an AIDS outpatient clinic as determined by chart review [see comments]: J Am Med Inform Assoc. 1994 Sep-Oct;1(5):395-403. Unique Identifier : AIDSLINE MED/95153427; Giuse NB; Huber JT; Giuse DA; Brown CW Jr; Bankowitz RA; Hunt S; University of Pittsburgh, PA.; OBJECTIVE: To examine the information needs of health care professionals in HIV-related clinical encounters, and to determine the suitability of existing information sources to address those needs. SETTING: HIV outpatient clinic. PARTICIPANTS: Seven health care professionals with diverse training and patient care invo
Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.: Cancer Lett. 1995 Jan 6;88(1):37-40. Unique Identifier : AIDSLINE MED/95153645; Ward NE; Gravitt KR; O'Brian CA; Department of Cell Biology, University of Texas M.D. Anderson; Cancer Center, Houston 77030.; This report describes the inhibition of protein kinase C (PKC) by a synthetic peptide corresponding to a viral sequence expressed in mammalian cells. The peptide corresponds to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (gp41), and it inhibits Ca(2+)- a
Inhibition of AIDS-Kaposi's sarcoma cell proliferation following retinoic acid receptor activation.: Cancer Res. 1995 Feb 15;55(4):823-9. Unique Identifier : AIDSLINE MED/95153673; Guo WX; Gill PS; Antakly T; Department of Pathology, University of Montreal, Quebec, Canada.; Retinoids, a group of natural and synthetic vitamin A analogues the receptors of which belong to the superfamily of steroid receptors, can exert profound effects on growth and/or differentiation of embryonic and neoplastic cells. Kaposi s sarcoma (KS), previously a rare multicentric neoplasm, has become epidemic with
Vitamin, trace element and peroxide status in HIV seropositive patients: asymptomatic patients present a severe beta-carotene deficiency.: Clin Chim Acta. 1994 Oct 14;230(1):35-42. Unique Identifier : AIDSLINE MED/95153878; Sappey C; Leclercq P; Coudray C; Faure P; Micoud M; Favier A; Groupe de Recherche et d'etude sur les Pathologies Oxydatives; (GREPO), Faculte de Medecine et de Pharmacie, La Tronche,; France.; We have investigated whether nutritional status and peroxidation process are associated with the degree of development of HIV infection. This was done by measuring the status of vitamins (E, A and beta-carotene), of antioxidant trace elements (zinc, selenium) and lipid peroxide levels (lipid hydroperoxides and thiobar
The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures.: Clin Exp Immunol. 1995 Feb;99(2):160-7. Unique Identifier : AIDSLINE MED/95153896; McHugh SM; Rifkin IR; Deighton J; Wilson AB; Lachmann PJ; Lockwood CM; Ewan PW; Molecular Immunopathology Unit, MRC Centre, Cambridge, UK.; Thalidomide is an effective immunomodulatory drug in man, but its mechanism of action remains unclear. We hypothesized that, in addition to its reported inhibitory effects on production of monocyte-derived tumour necrosis factor-alpha (TNF-alpha), thalidomide might be effective at the level of Th immunoregulation. In
The affinity of IgG antibodies to gag p24 and p17 in HIV-1-infected patients correlates with disease progression.: Clin Exp Immunol. 1995 Feb;99(2):175-81. Unique Identifier : AIDSLINE MED/95153898; Chargelegue D; Stanley CM; O'Toole CM; Colvin BT; Steward MW; London Hospital Medical College, UK.; The affinity of anti-gag antibody was studied for up to 9 years (1984-1993) in sera from 15 HIV-1+ patients with haemophilia. On the basis of their 1993 clinical status patients were divided into two groups: (i) patients who remained asymptomatic (n = 9); and (ii) those who progressed to AIDS between late 1987 and 199
Comparison of activation marker and TCR V beta gene product expression by CD4+ and CD8+ T cells in peripheral blood and lymph nodes from HIV-infected patients.: Clin Exp Immunol. 1995 Feb;99(2):182-8. Unique Identifier : AIDSLINE MED/95153899; Ramzaoui S; Jouen-Beades F; Michot F; Borsa-Lebas F; Humbert G; Tron F; Service de Chirurgie Digestive, CHU Charles Nicolle, Rouen,; France.; Since lymphoid organs constitute the site of active and progressive HIV disease, analysis of their lymphocytes may provide more accurate information on T cell abnormalities than that obtained from studying peripheral blood lymphocytes. The objective of this study was to compare the expressions of activation markers an
Efficacy of HIV-specific and 'antibody-independent' mechanisms for complement activation by HIV-infected cells.: Clin Exp Immunol. 1995 Feb;99(2):189-95. Unique Identifier : AIDSLINE MED/95153900; Saarloos MN; Lint TF; Spear GT; Department of Immunology/Microbiology, Rush Medical School,; Chicago, IL 60612.; Previous studies in this laboratory have shown that efficient activation of complement (C) on HIV isolates and HIV-infected cells requires the binding of specific anti-HIV antibodies, while other investigators have observed antibody-independent C activation. In an attempt to clarify these disparate findings, we inve
Low serum levels of dehydroepiandrosterone may cause deficient IL-2 production by lymphocytes in patients with systemic lupus erythematosus (SLE).: Clin Exp Immunol. 1995 Feb;99(2):251-5. Unique Identifier : AIDSLINE MED/95153910; Suzuki T; Suzuki N; Engleman EG; Mizushima Y; Sakane T; Department of Immunology, St. Marianna University School of; Medicine, Kanagawa, Japan.; The principal cause of IL-2 deficiency, a common feature of both murine lupus and human SLE, remains obscure. Recent studies of our own as well as others have shown that dehydroepiandrosterone (DHEA), an intermediate compound in testosterone synthesis, significantly up
Telangiectases in human immunodeficiency virus-positive patients.: Cutis. 1994 Feb;53(2):79-80. Unique Identifier : AIDSLINE MED/95154019; MacFarlane DF; Gregory N; College of Physicians and Surgeons, Columbia University,; Department of Dermatology, New York, New York 10032.; Telangiectases have been noted as a cutaneous manifestation of the acquired immunodeficiency syndrome and are characteristically distributed across the upper chest in a crescentic pattern between the clavicles. We describe the observation of diffuse upper body telangiectasia in a forty-seven-year-old, human immunodefi
Excessive growth of eyelashes in patients with acquired immunodeficiency syndrome.: Cutis. 1994 Feb;53(2):83-4. Unique Identifier : AIDSLINE MED/95154021; Baccard M; Morel P; Service de Dermatologie, Hopital Saint-Louis, Paris, France.; We report a new case of excessive growth of eyelashes in a patient seropositive for human immunodeficiency virus 1. The exact mechanism of this hypertrichosis is still unknown. Although this sign seems to occur late in the human immunodeficiency virus infection, we believe early recognition of this manifestation could
Cutaneous cryptococcosis with molluscum contagiosum coinfection in a patient with acquired immunodeficiency syndrome.: Cutis. 1994 Feb;53(2):88-90. Unique Identifier : AIDSLINE MED/95154023; Sulica RL; Kelly J; Berberian BJ; Glaun R; Division of Dermatology, Georgetown University Medical Center,; Washington, DC 20007.; We report the first patient with acquired immunodeficiency syndrome in whom molluscum contagiosum and Cryptococcus neoformans were documented in the same cutaneous lesion. While cases of the co-occurrence of two pathologic entities in patients with acquired immunodeficiency syndrome have been reported, namely
[Risk of infection caused by homologous blood transfusion]: Chirurg. 1994 Dec;65(12):1071-4. Unique Identifier : AIDSLINE MED/95154031; Kuhnl P; Loliger C; Laufs R; Abteilung fur Transfusionsmedizin, Transplantationsimmunologie,; Chirurgische Universitatsklinik Hamburg.; Compared with other nosocomial infections, transfusion-associated infectious risks are of minor relevance in the Federal Republic of Germany today. The actual spectrum of measures for an optimal degree of safety of blood components comprises a careful donor selection, highly sensi
[Preoperative autologous blood donation and disposition. Possibilities and prerequisites]: Chirurg. 1994 Dec;65(12):1075-9. Unique Identifier : AIDSLINE MED/95154032; Mempel W; Lehr L; Transfusionszentrum, Medizinische Klinik III,; Ludwig-Maximilians-Universitat, Munchen, Klinikum Grosshadern.; Preoperative blood deposit can help to avoid the risks of homologous blood transfusions. However, it is necessary that prerequisites concerning medicine standard, organisation, technical questions and administrative aspects have to be fulfilled.
HIV infection and cocaine use in methadone maintained and untreated intravenous drug users.: Drug Alcohol Depend. 1994 Oct;36(2):109-13. Unique Identifier : AIDSLINE MED/95154177; Meandzija B; O'Connor PG; Fitzgerald B; Rounsaville BJ; Kosten TR; Department of Psychiatry, Yale University School of Medicine, New; Haven, CT 06511.; In a survey of 424 intravenous drug users (IVDUs) of whom 107 were currently enrolled in a methadone maintenance program (MMP), we assessed risk behaviors for Human Immunodeficiency Virus (HIV) transmission and conducted HIV testing. We found that African Americans were over-represented in the HIV infected group and u
Suspected determinants of enrollment into detoxification and methadone maintenance treatment among injecting drug users.: Drug Alcohol Depend. 1994 Oct;36(2):129-38. Unique Identifier : AIDSLINE MED/95154180; Schutz CG; Rapiti E; Vlahov D; Anthony JC; National Institute on Drug Abuse/Intramural Research Program,; Etiology Branch, Baltimore, MD 21224.; Our primary aim in this study has been to evaluate selected conditions thought to influence the entry of injecting drug users (IDU) into detoxification and methadone maintenance programs, making use of a prospective study design to strengthen a cross-sectional investigation of these conditions. To begin our investigat
Anabolic steroid users identified by needle and syringe exchange contact.: Drug Alcohol Depend. 1994 Oct;36(2):153-5. Unique Identifier : AIDSLINE MED/95154183; Morrison CL; Maryland Centre, Liverpool, UK.; The increasing prevalence in the extent of misuse of anabolic-androgenic steroids has been well recognised in the United States and more recently in Great Britain. The injecting misuse of steroids carries with it considerable risks in relation to liver damage, lipid metabolism disturba
[Detection of antibodies against the virus of enzootic bovine leukosis in serum and milk samples using an immunoblot]: DTW Dtsch Tierarztl Wochenschr. 1994 Oct;101(10):402-5. Unique Identifier : AIDSLINE MED/95154202; Bunger I; Khalaf H; Cripe C; Rimpler M; Staatlichen Veterinaruntersuchungsamt Hannover.; A method for detection of antibodies against the enzootic bovine leukemia virus in single serum and milk samples, as well as in pooled milk samples, is described. After the electrophoretical separation of the antigen proteins with SDS-PAGE, a transfer onto an immobilizing membrane is done, followed by immunodetection
The epidemiology of the acquired immunodeficiency syndrome in the 1990s.: Emerg Med Clin North Am. 1995 Feb;13(1):1-25. Unique Identifier : AIDSLINE MED/95154212; Quinn TC; Division of Infectious Diseases, Johns Hopkins University School; of Medicine.; Since the recognition of AIDS in 1981, it has become a global pandemic afflicting more than 6 million people worldwide. To date, more than 22 million people are infected with HIV-1, the cause of AIDS, and more than 40 million people may be infected with HIV by the year 2000. In the United
Noninfectious manifestations of human immunodeficiency virus infection.: Emerg Med Clin North Am. 1995 Feb;13(1):105-31. Unique Identifier : AIDSLINE MED/95154213; Galetto G; Morrow CT; Department of Emergency Medicine, Johns Hopkins Bayview Medical; Center, Baltimore, Maryland.; Infection with HIV is associated with an array of noninfectious conditions of which the emergency physician should be aware. The knowledge of these complications and their differentiation from microbial conditions also common with HIV is essential in treating such patients in the emergency department. These complicati
Adverse reactions to therapy for HIV infection.: Emerg Med Clin North Am. 1995 Feb;13(1):133-46. Unique Identifier : AIDSLINE MED/95154214; Barditch-Crovo P; Chaisson RE; Johns Hopkins University School of Medicine, Baltimore, Maryland.; Although chronic drug therapy with antiretroviral agents and chemoprophylaxis has led to longer survival without disease, high rates of adverse reactions to agents used to treat HIV infection have been reported. The incidence of adverse drug reactions in patients with HIV infection varies with the type of drug therapy
HIV infections in children.: Emerg Med Clin North Am. 1995 Feb;13(1):147-62. Unique Identifier : AIDSLINE MED/95154215; Walker AR; Division of General Pediatrics and Adolescent Medicine, Johns; Hopkins University School of Medicine, Baltimore, Maryland.; HIV infection in infants and children who acquire it early in life is quite different from HIV infection in adults. The immune deficiency that results occurs in an immunologically naive organism, resulting in a larger role for common pathogens in causing severe infections. The immune deficiency is superimposed on age-
Psychiatric issues and emergencies in HIV infection.: Emerg Med Clin North Am. 1995 Feb;13(1):163-77. Unique Identifier : AIDSLINE MED/95154216; Lyketsos CG; Fishman M; Treisman G; AIDS Psychiatry Service, Johns Hopkins Hospital, Baltimore,; Maryland.; Emergency departments are frequently the entry point for patients infected with HIV. Psychiatric conditions may be the initial predominant presentation or an important concomitant factor. Because of the complexities of HIV infection, the serious medical nature of its associated psychiatric complications, the frequent
Tuberculosis in the HIV-infected patient.: Emerg Med Clin North Am. 1995 Feb;13(1):179-98. Unique Identifier : AIDSLINE MED/95154217; Waxman S; Gang M; Goldfrank L; Department of Emergency Medicine, Bellevue Hospital Center, New; York, New York.; After decades of decline, tuberculosis has emerged as a global health challenge. In the setting of HIV immunocompromise, TB occurs frequently, early, and often atypically. New infections can take an accelerated course. The usual tests for diagnosing Mycobacterium tuberculosis infection are less sensitive when CD4+ cou
Risks for exposures to and infection with HIV among health care providers in the emergency department.: Emerg Med Clin North Am. 1995 Feb;13(1):199-211. Unique Identifier : AIDSLINE MED/95154218; Henderson DK; Warren Grant Magnuson Clinical Center, National Institutes of; Health, Bethesda, Maryland.; This article reviews the information available that is relevant to the risk of occupational infection with HIV, attempts to frame this evidence in perspective for emergency health care providers, and underscores the strategies that have been shown to be effective in reducing these risks.
HIV and AIDS. Legal and ethical issues in the emergency department.: Emerg Med Clin North Am. 1995 Feb;13(1):213-23. Unique Identifier : AIDSLINE MED/95154219; Derse AR; Center for the Study of Bioethics, Medical College of Wisconsin,; Milwaukee.; The treatment of individuals infected with HIV in the emergency department presents difficult and unique medical, social, legal, and ethical issues. These issues include: (1) informed consent for testing for HIV status, (2) mandatory testing of patients for HIV, (3) confidentiality of patients infected with HIV, (4) t
Biology of HIV-1 and treatment strategies.: Emerg Med Clin North Am. 1995 Feb;13(1):27-42. Unique Identifier : AIDSLINE MED/95154220; Terwilliger EF; Department of Medicine, Harvard Medical School, Boston,; Massachusetts.; Effective vaccines and treatments for HIV-1, the retrovirus responsible for AIDS, continue to be elusive. Many of the obstacles to more effective intervention can be traced to special properties of the virus itself. Although great progress has been made in our understanding of the biology of the virus, important gaps
HIV testing.: Emerg Med Clin North Am. 1995 Feb;13(1):43-59. Unique Identifier : AIDSLINE MED/95154221; Hansen KN; Emergency Department, Suburban Hospital, Bethesda, Maryland.; Testing for HIV infection is not generally required for the appropriate treatment of medical emergencies. Current standard HIV tests rely on the detection of antibodies to the HIV virus and are among the most sensitive and specific tests used in medicine. Standard HIV tests can be unreliable for detecting infection in
Presentations and emergency department evaluation of HIV infection.: Emerg Med Clin North Am. 1995 Feb;13(1):61-71. Unique Identifier : AIDSLINE MED/95154222; Marco CA; Department of Emergency Medicine, Johns Hopkins University School; of Medicine, Baltimore, Maryland.; Patients with HIV infection may present with a wide variety of symptomatology, both related and unrelated to HIV infection. Evaluation should be conducted in an orderly fashion and should focus on the involved system, with particular attention to ruling out treatable infection, malignancy, or other HIV-related disease
Infectious complications of HIV disease.: Emerg Med Clin North Am. 1995 Feb;13(1):73-104. Unique Identifier : AIDSLINE MED/95154223; Gallant JE; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland.; HIV disease is associated with a wide variety of infections caused by bacteria, viruses, parasites, and fungi. Although some infections occur only in patients with very low CD4 cell counts, others require only mild to moderate immunosuppression. This article discusses the opportunistic infections associated with HIV d
Mathematical modelling of immunotherapy in HIV infection.: Folia Biol (Praha). 1994;40(4):193-9. Unique Identifier : AIDSLINE MED/95154536; Dolezal J; Hraba T; Institute of Information Theory and Automation, Academy of; Sciences of the Czech Republic, Praha.; The effect of active or passive immunotherapy on HIV infection was simulated using a mathematical model of CD4+ lymphocyte depletion. Permanently effective active immunotherapy increased CD4+ lymphocyte counts to a steady-state level depending on the intensity of the therapy. Active HIV immunization effective for one
Effects of surgical trauma of laparoscopic vs. open cholecystectomy.: Hepatogastroenterology. 1994 Oct;41(5):471-6. Unique Identifier : AIDSLINE MED/95154790; Dionigi R; Dominioni L; Benevento A; Giudice G; Cuffari S; Bordone N; Caravati F; Carcano G; Gennari R; Department of Surgery, Clinica Chirurgica, University of Pavia,; Italy.; The effects of surgical trauma resulting from laparoscopic cholecystectomy and open cholecystectomy, were compared by assessing the postoperative acute phase alterations of selected plasma proteins, hormones and lymphocyte subpopulations in fifty-seven patients prior to elective cholecystectomy. Patients were prospect
Absence of HTLV-I infection in some Indian populations.: Indian J Med Res. 1994 Oct;100:160-2. Unique Identifier : AIDSLINE MED/95154909; Roy M; Das MK; Ishida T; Das SK; Dey B; Banerjee S; Majumder PP; Indian Statistical Institute, Calcutta.; A total of 946 adults belonging to ten population groups of Uttar Pradesh and West Bengal were screened for HTLV-I using a gelatin particle agglutination test. The percentage of seroreactive cases varied from 0 to 5.8 per cent. The overall prevalence of seroreactivity was 2 per cent. Of the 19 seroreactive cases, 15 w
Modifying the process of treatment to meet the threat of AIDS.: Int J Addict. 1994 Nov;29(13):1739-52. Unique Identifier : AIDSLINE MED/95154945; Brown BS; Needle RH; Department of Psychology, University of North Carolina at; Wilmington 28403-3297.; Treatment for drug users is unlikely to receive sufficient resources to expand to the level of treatment need. Moreover, there is indication that a substantial minority of injection drug users have never initiated needed treatment in spite of long histories of injecting drugs. Given the potential for that population t
The progressive outer retinal necrosis syndrome.: Int Ophthalmol. 1994;18(3):163-5. Unique Identifier : AIDSLINE MED/95154969; Holland GN; UCLA School of Medicine, Jules Stein Eye Institute 90024-7003.; The progressive outer retinal necrosis (PORN) syndrome is a recently described clinical variant of necrotizing herpetic retinopathy in patients with the acquired immunodeficiency syndrome (AIDS). It is caused by varicellazoster virus infection of the retina. Its course and clinical features distinguish it from the acu
Cocaine blunts human CD4+ cell activation.: Immunopharmacology. 1994 Nov-Dec;28(3):233-40. Unique Identifier : AIDSLINE MED/95155012; Chiappelli F; Frost P; Manfrini E; Lee P; Pham L; Garcia C; Daley S; Kung M; Villanueva P; Laboratory of Human Oral and Molecular Immunology, Diagnostic; Sciences, UCLA School of Dentistry.; Cocaine is reported to be immunotoxic. The biochemical mechanisms responsible for the immunopharmacological outcomes of cocaine in vivo and in vitro remain, however, to be fully elucidated. Our experimental data confirm that exposure of normal human T cells to micromolar concentrations of cocaine modulates T-cell resp
Rhodococcus equi: fatal pneumonia in a patient without AIDS.: Heart Lung. 1994 Nov-Dec;23(6):519-20. Unique Identifier : AIDSLINE MED/95155026; Walsh RD; Cunha BA; Infectious Disease Division, Winthrop-University Hospital,; Mineola, NY 11530.; Rhodococcus equi infections are being recognized with greater frequency in immunocompromised patients and the population infected with the human immunodeficiency virus (HIV). R. equi usually causes a progressive pneumonia that may or may not cavitate and is relatively refractory to antibiotic therapy. We report a case
Educating health care professionals in human immunodeficiency virus disease and policies: an ongoing challenge.: Heart Lung. 1994 Nov-Dec;23(6):521-3. Unique Identifier : AIDSLINE MED/95155027; Lachat MF; Georgetown University, School of Nursing, Washington, D.C. 20007.
Synergistic antimetastatic effects of lentinan and interleukin 2 with pre- and post-operative treatments.: Jpn J Cancer Res. 1994 Dec;85(12):1288-97. Unique Identifier : AIDSLINE MED/95155164; Hamuro J; Takatsuki F; Suga T; Kikuchi T; Suzuki M; Central Research Laboratories, Ajinomoto Co., Inc., Kawasaki.; The antimetastatic activity of a combination of lentinan and interleukin 2 ( IL-2 ) was evaluated against spontaneously metastatic 3-methylcholanthrene-induced DBA/2.MC.CS.T fibrosarcoma. Although pre-operative treatment with either IL-2 or lentinan alone exerted little
The clinical application of recombinant erythropoietin in the HIV-infected patient.: Hematol Oncol Clin North Am. 1994 Oct;8(5):945-59. Unique Identifier : AIDSLINE MED/95155192; Glaspy JA; Chap L; Department of Medicine, University of California, Los Angeles; School of Medicine.; Patients with HIV infection frequently develop clinically significant anemia, either as a manifestation of the HIV or as a result of therapy with medications such as zidovudine. Therapy with recombinant human erythropoietin can increase hemoglobin levels in these patients, decreasing transfusion requirements and impro
Nephrotic syndrome in a HIV seropositive patient.: J Assoc Physicians India. 1994 Jun;42(6):500. Unique Identifier : AIDSLINE MED/95155231; Singh NP; Pillai D; Kar C; Sridharan M; Das AK
Characterization of the human spuma retrovirus integrase by site-directed mutagenesis, by complementation analysis, and by swapping the zinc finger domain of HIV-1.: J Biol Chem. 1995 Feb 17;270(7):2957-66. Unique Identifier : AIDSLINE MED/95155376; Pahl A; Flugel RM; Abteilung Retrovirale Genexpression, Deutsches; Krebsforschungszentrum, Heidelberg, Federal Republic of Germany.; The human spuma retrovirus or foamy virus integrase (HFV IN) is an enzymatically active protein consisting of domains similar to other retroviral integrases: an amino-terminal HH-CC finger, a centrally located region with the conserved D, D-35-E protein motif required for catalytic activity and oligomerization, and at
Differential transcriptional activation in vitro by NF-kappa B/Rel proteins.: J Biol Chem. 1995 Feb 17;270(7):3123-31. Unique Identifier : AIDSLINE MED/95155399; Lin R; Gewert D; Hiscott J; Terry Fox Molecular Oncology Group, Lady Davis Institute for; Medical Research, Jewish General Hospital, Montreal, Quebec,; Canada.; Distinct NF-kappa B subunit combinations contribute to the specificity of NF-kappa B-mediated transcriptional activation and to the induction of multiple cytokine genes including interferon-beta (IFN-beta). To evaluate the regulatory influence of different homo- and heterodimers, NF-kappa B subunits were analyzed for
Biochemical and genetic definition of the cellular protease required for HIV-1 gp160 processing.: J Biol Chem. 1995 Feb 17;270(7):3154-9. Unique Identifier : AIDSLINE MED/95155403; Franzusoff A; Volpe AM; Josse D; Pichuantes S; Wolf JR; Department of Cellular and Structural Biology, University of; Colorado Medical School, Denver 80262.; The surface glycoproteins of enveloped viruses bind to target cell receptors and trigger membrane fusion for infection. The human immunodeficiency virus 1 (HIV-1) envelope glycoprotein gp120 (CD4 binding protein) and gp41 (transmembrane fusion protein) are initially synthesized as a gp160 precursor. The intracellular
An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer.: J Biol Chem. 1995 Feb 17;270(7):3320-6. Unique Identifier : AIDSLINE MED/95155427; Ellison V; Gerton J; Vincent KA; Brown PO; Department of Biochemistry, Stanford University, California; 94305.; Integrase mediates integration of the retroviral genome into a host cell chromosome, an essential step in the viral life cycle. In vitro, a stable complex containing only purified human immunodeficiency virus (HIV) integrase and a model viral DNA substrate processively executes the 3 -end processing and DNA joining st
A ring-enhancing parietal lobe lesion in an HIV-positive man.: Hosp Pract (Off Ed). 1995 Feb 15;30(2):66-8. Unique Identifier : AIDSLINE MED/95155485; Fred HL; Dunn K; University of Texas Health Science Center at Houston.
Rapid screening for early detection of mother-to-child transmission of human immunodeficiency virus type 1.: J Clin Microbiol. 1994 Nov;32(11):2641-5. Unique Identifier : AIDSLINE MED/95155575; Cassol S; Butcher A; Kinard S; Spadoro J; Sy T; Lapointe N; Read S; Gomez P; Fauvel M; Major C; et al; British Columbia Centre for Excellence in HIV/AIDS, Saint Paul's; Hospital, Canada.; The testing of dried blood spots (DBSs) for the presence of human immunodeficiency type 1 (HIV-1) proviral DNA by PCR was first described in 1991. The technology has proven to be particularly valuable for resolving the infection status in HIV-1-indeterminate infants born to HIV-1-seropositive mothers. To broaden the a
Comparative quantitation of human cytomegalovirus DNA in blood leukocytes and plasma of transplant and AIDS patients.: J Clin Microbiol. 1994 Nov;32(11):2709-17. Unique Identifier : AIDSLINE MED/95155588; Gerna G; Furione M; Baldanti F; Sarasini A; Virus Laboratory, University of Pavia, Italy.; A new method for the quantitation of human cytomegalovirus (HCMV) DNA was used to determine the levels of viral DNA in parallel in 120 blood leukocyte (leukoDNAemia) and plasma (plasmaDNAemia) samples from 8 heart or heart-lung transplant patients and 17 AIDS patients with dissemin
Cryptosporidium antigen detection in human feces by reverse passive hemagglutination assay [see comments]: J Clin Microbiol. 1994 Nov;32(11):2755-9. Unique Identifier : AIDSLINE MED/95155595; Farrington M; Winters S; Walker C; Miller R; Rubenstein D; Clinical Microbiology and Public Health Laboratory, Addenbrooke's; NHS Trust, Cambridge, United Kingdom.; A reverse passive hemagglutination (RPH) assay was developed for Cryptosporidium oocyst antigen with an antioocyst monoclonal antibody (MAb; MAb-C1) coupled to stabilized sheep erythrocytes. RPH was compared with microscopy of auramine-phenol-stained smears of 56 oocyst-positive fecal samples, each of which was tested
Polyclonal and monoclonal antibody and PCR-amplified small-subunit rRNA identification of a microsporidian, Encephalitozoon hellem, isolated from an AIDS patient with disseminated infection.: J Clin Microbiol. 1994 Nov;32(11):2760-8. Unique Identifier : AIDSLINE GENBANK/L19070; Visvesvara GS; Leitch GJ; da Silva AJ; Croppo GP; Moura H; Wallace S; Slemenda SB; Schwartz DA; Moss D; Bryan RT; et al; Division of Parasitic Diseases, Centers for Disease Control and; Prevention, Atlanta, Georgia 30341-3724.; Microsporidia are primitive, spore-forming, mitochondria-lacking, eukaryotic protozoa that are obligate intracellular parasites. They are known to parasitize almost every group of animals including humans. Recently, microsporidia have increasingly been found to infect patients with AIDS. Five genera (Encephalitozoon,
Value of PCR for evaluating occurrence of parasitemia in immunocompromised patients with cerebral and extracerebral toxoplasmosis.: J Clin Microbiol. 1994 Nov;32(11):2813-9. Unique Identifier : AIDSLINE MED/95155603; Khalifa K el-S; Roth A; Roth B; Arasteh KN; Janitschke K; Fachgebiet fur Klinische Parasitologie, Robert Koch-Institute,; Berlin, Germany.; PCR was used to evaluate the occurrence of Toxoplasma gondii parasitemia by detection of the B1 gene in blood samples in two groups of immunosuppressed patients (148 subjects) suspected of having cerebral or extracerebral infection, respectively. Group I consisted of 52 patients with AIDS with suspected cerebral toxop
Detection of human immunodeficiency virus type 1 (HIV-1) in heel prick blood on filter paper from children born to HIV-1-seropositive mothers.: J Clin Microbiol. 1994 Nov;32(11):2858-60. Unique Identifier : AIDSLINE MED/95155616; Nyambi PN; Fransen K; De Beenhouwer H; Chomba EN; Temmerman M; Ndinya-Achola JO; Piot P; van der Groen G; Institute of Tropical Medicine, Antwerp, Belgium.; The human immunodeficiency virus type 1 (HIV-1) DNA PCR results of 94 dried blood spot (DBS) samples on filter paper and corresponding venous blood in EDTA obtained from infants born to HIV-1-seropositive mothers were compared. In addition, the results of HIV-1 DNA PCR on DBS and the HIV-1 RNA PCR from plasma of 70 pa
Serovars of Mycobacterium avium complex isolated from patients in Denmark.: J Clin Microbiol. 1994 Nov;32(11):2880-2. Unique Identifier : AIDSLINE MED/95155624; Askgaard DS; Giese SB; Thybo S; Lerche A; Bennedsen J; Mycobacteria Department, Statens Seruminstitut, Copenhagen,; Denmark.; Danish isolates of Mycobacterium avium complex were serotyped by the use of seroagglutination. The most prevalent serovars among patients with AIDS (n = 89) were 4 and 6, while among non-AIDS patients the most prevalent serovars were 1, 6, and 4, with no major differences between those in patients with pulmonary disea
A case of conversion from MT-2-positive to MT-2-negative phenotype [letter; comment]: J Clin Microbiol. 1994 Nov;32(11):2884-5. Unique Identifier : AIDSLINE MED/95155627; Ruiz L; Clotet B
Elevation of IgE in HIV-infected children and its correlation with the progression of disease.: J Allergy Clin Immunol. 1995 Feb;95(2):627-32. Unique Identifier : AIDSLINE MED/95155715; Vigano A; Principi N; Crupi L; Onorato J; Vincenzo ZG; Salvaggio A; Paediatric Department IV, University of Milan, L. Sacco Hospital,; Italy.; BACKGROUND: According to recent data, a switch from a TH1 to a TH2 pattern of cytokines might be a critical step in the progression of human immunodeficiency virus (HIV) infection. Previous studies have demonstrated a disturbance in IgE synthesis in HIV-infected adults. METHODS: Fifty-eight children infected verticall
Aspartame-induced hives [letter; comment]: J Allergy Clin Immunol. 1995 Feb;95(2):639-40. Unique Identifier : AIDSLINE MED/95155719; Kulczycki A Jr
[Immunodeficiency caused by retrovirus infections]: Nippon Naika Gakkai Zasshi. 1994 Nov 10;83(11):1996-9. Unique Identifier : AIDSLINE MED/95155861; Koyanagi Y
Functional deficiencies in two distinct interferon alpha-producing cell populations in peripheral blood mononuclear cells from human immunodeficiency virus seropositive patients.: J Leukoc Biol. 1995 Feb;57(2):214-20. Unique Identifier : AIDSLINE MED/95155887; Feldman SB; Milone MC; Kloser P; Fitzgerald-Bocarsly P; Graduate School of Biomedical Sciences, University of Medicine; and Dentistry of New Jersey, Newark.; Two populations of IFN-alpha producing cells (IPC) were examined to determine whether they are coordinately dysregulated in human immunodeficiency virus (HIV) disease. IFN-alpha produced in response to herpes simplex virus (HSV) and Sendai virus (SV) was measured and the frequencies of the IPC were obtained by ELISpot
Laboratory study of HIV-1 and HTLV-I/II coinfection.: J Med Virol. 1994 Oct;44(2):132-43. Unique Identifier : AIDSLINE MED/95156017; Beilke MA; Greenspan DL; Impey A; Thompson J; Didier PJ; Section of Infectious Diseases, Tulane University School of; Medicine, New Orleans, LA 70112.; A Retroviral Coinfection Clinic was established in 1991 at Charity Hospital Medical Center of Louisiana to study patients dually infected with human immunodeficiency virus (HIV) and human T lymphotropic virus (HTLV-I, HTLV-II). Eight patients were evaluated clinically, and by immunological and virological studies. Mul
Detection of cytomegalovirus-matrix protein (pp65) in leukocytes of HIV-infected patients with painful peripheral neuropathy.: J Med Virol. 1994 Oct;44(2):172-5. Unique Identifier : AIDSLINE MED/95156022; Mastroianni CM; Sebastiani G; Folgori F; Ajassa C; Vullo V; Volpi A; Institute of Infectious Diseases, La Sapienza University, Rome,; Italy.; Painful peripheral neuropathy (PPN) in HIV-infected patients has been increasingly associated with cytomegalovirus ( CMV ) infection at other sites. In the last few years, the
Evaluation of commercially available assays for antibodies to HIV-1 in serum obtained from South African patients infected with HIV-1 subtypes B, C, and D.: J Med Virol. 1994 Nov;44(3):223-8. Unique Identifier : AIDSLINE MED/95156031; Engelbrecht S; de Jager GJ; van Rensburg EJ; Department of Medical Virology, University of Stellenbosch and; Tygerberg Hospital, South Africa.; Between 1984 and 1990, virus was routinely isolated and serum collected from patients diagnosed at hospitals in the Western Cape as suffering from AIDS or AIDS-related conditions (ARC). From these, 17 virus strains were selected at random for sequencing and molecular characterisation of the env gene. The strains were
Novel naphthoquinones from Conospermum incurvum.: J Nat Prod. 1994 Nov;57(11):1511-6. Unique Identifier : AIDSLINE MED/95156071; Dai JR; Decosterd LA; Gustafson KR; Cardellina JH 2nd; Gray GN; Boyd MR; Laboratory of Drug Discovery Research and Development, National; Cancer Institute, Frederick, Maryland 21702-1201.; During the reisolation of the trimeric naphthoquinone derivative conocurvone [1] from an extract of the Australian shrub Conospermum incurvum, six monomeric naphthoquinones were isolated. These include three novel 1,4-naphthoquinone derivatives: 3-methyl-14,15-dihydro-15-hydroxyteretifolione B [3], 3-methyl-14,15-dihy
A neuropathological study of paraparetic rats injected with HTLV-I-producing T cells.: J Neurol Sci. 1994 Nov;126(2):101-8. Unique Identifier : AIDSLINE MED/95156083; Mizusawa H; Kushida S; Matsumura M; Tanaka H; Ami Y; Hori M; Kobayashi M; Uchida K; Yagami K; Yoshizawa T; et al; Department of Neurology, University of Tsukuba, Ibaraki-ken,; Japan.; In order to clarify the pathogenesis of HTLV-I-associated myelopathy or tropical spastic paraparesis (HAM/TSP), we injected HTLV-I-producing rabbit or human T cells intravenously into WKA and F344 rats. Infection was confirmed from increase in the anti-HTLV-I antibody titer and from the presence of HTLV-I proviral DNA
Prevention of HIV coat protein (gp120) toxicity in cortical cell cultures by riluzole.: J Neurol Sci. 1994 Nov;126(2):133-7. Unique Identifier : AIDSLINE MED/95156087; Sindou P; Couratier P; Esclaire F; Yardin C; Bousseau A; Hugon J; Unite de Neurobiologie Cellulaire, Faculte de Medecine,; Limoges, France.; Neurological complications observed in HIV-infected patients are very frequent. Neocortical lesions include reduced neuronal density due to neuronal degeneration. The HIV envelope protein gp120 has potent neurotoxic properties in cell cultures blocked either by NMDA antagonists or calcium channel antagonists. Moreover
Antiretroviral activity of furocoumarins plus UVA light detected by a replication-defective retrovirus.: J Photochem Photobiol B. 1994 Dec;26(3):241-7. Unique Identifier : AIDSLINE MED/95156188; Miolo G; Tomanin R; De Rossi A; Dall'Acqua F; Zacchello F; Scarpa M; Department of Pharmaceutical Sciences, University of Padova,; Italy.; The replication defective retrovirus, pXM5(N2), was used for an easy, safe and reproducible test for the screening of furocoumarins with antiretroviral activity. High titer viral supernatants have been photomodified by UVA light (20 kJ m-2) in the presence of different concentrations of two psolarens (8-methoxypsorale
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.: J Med Chem. 1995 Feb 3;38(3):443-52. Unique Identifier : AIDSLINE MED/95156420; Cushman M; Golebiewski WM; Pommier Y; Mazumder A; Reymen D; De Clercq E; Graham L; Rice WG; Department of Medicinal Chemistry and Pharmacognosy, School of; Pharmacy and Pharmacal Sciences, Purdue University, West; Lafayette, Indiana 47907.; Several new analogues of the novel anti-HIV agent cosalane have been synthesized and evaluated as inhibitors of HIV-1 integrase and protease, HIV-1 replication, HIV-1 and HIV-2 cytopathicity, HIV-1- and HIV-2-mediated syncytium formation, and cytopathicity of a variety of human pathogenic viruses. The congeners displa
Pimelautide or trimexautide as built-in adjuvants associated with an HIV-1-derived peptide: synthesis and in vivo induction of antibody and virus-specific cytotoxic T-lymphocyte-mediated response.: J Med Chem. 1995 Feb 3;38(3):459-65. Unique Identifier : AIDSLINE MED/95156422; Deprez B; Gras-Masse H; Martinon F; Gomard E; Levy JP; Tartar A; Faculte de Pharmacie, URA CNRS 1309, Institut Pasteur de Lille,; France.; Covalent association of lipopeptidic immunostimulants is known to improve the immunogenicity of short peptides. In this paper, we describe the synthesis of four analytically pure immunogens, prepared by two different strategies, in which a hexadecameric peptide (V3) derived from the principal neutralizing domain of HI
De novo design of enzyme inhibitors by Monte Carlo ligand generation.: J Med Chem. 1995 Feb 3;38(3):466-72. Unique Identifier : AIDSLINE MED/95156423; Gehlhaar DK; Moerder KE; Zichi D; Sherman CJ; Ogden RC; Freer ST; Agouron Pharmaceuticals, Inc., San Diego, California 92121.; A new computational method for the in situ generation of small molecules within the binding site of a protein is described. The method has been evaluated using two well-studied systems, dihydrofolate reductase and thymidylate synthase. The method has also been used to guide improvements to inhibitors of HIV-1 protease
Repetitive Alu elements form a cruciform structure that regulates the function of the human CD8 alpha T cell-specific enhancer.: J Mol Biol. 1995 Feb 10;246(1):63-73. Unique Identifier : AIDSLINE MED/95156490; Hanke JH; Hambor JE; Kavathas P; Department of Molecular Genetics and Protein Chemistry, Pfizer; Central Research, Groton, CT 06340.; We previously identified a T cell-specific enhancer in the last intron of the human CD8 alpha gene that is adjacent to a sequence element that significantly represses enhancer function. This negative regulatory region consists of a half-Alu sequence that has potential to base-pair with a downstream Alu element, which
Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins.: J Virol. 1995 Mar;69(3):1429-34. Unique Identifier : AIDSLINE MED/95156566; Hou S; Mo XY; Hyland L; Doherty PC; Department of Immunology, St. Jude Children's Research Hospital,; Memphis, Tennessee 38105.; The development of Sendai virus-specific cytotoxic T-lymphocyte (CTL) effectors and precursors (CTLp) has been compared for mice that are homozygous (-/-) for a disruption of the H-2I-Ab class II major histocompatibility complex glycoprotein and for normal (+/+) controls. The generation of CD8+ CTLp was not diminished
Temperature dependence of cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1.: J Virol. 1995 Mar;69(3):1462-72. Unique Identifier : AIDSLINE MED/95156570; Frey S; Marsh M; Gunther S; Pelchen-Matthews A; Stephens P; Ortlepp S; Stegmann T; Department of Biophysical Chemistry, Biozentrum of the University; of Basel, Switzerland.; We investigated cell-cell fusion induced by the envelope glycoprotein of human immunodeficiency virus type 1 strain IIIB expressed on the surface of CHO cells. These cells formed syncytia when incubated together with CD4-positive human lymphoblastoid SupT1 cells or HeLa-CD4 cells but not when incubated with CD4-negati
Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus.: J Virol. 1995 Mar;69(3):1500-9. Unique Identifier : AIDSLINE MED/95156575; McElhinny JA; MacMorran WS; Bren GD; Ten RM; Israel A; Paya CV; Department of Immunology, Mayo Clinic, Rochester, Minnesota; 55905.; The mechanisms regulating human immunodeficiency virus (HIV) persistence in human monocytes/macrophages are partially understood. Persistent HIV infection of U937 monocytic cells results in NF-kappa B activation. Whether virus-induced NF-kappa B activation is a mechanism that favors continuous viral replication in mac
The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation.: J Virol. 1995 Mar;69(3):1510-20. Unique Identifier : AIDSLINE MED/95156576; Bour S; Schubert U; Strebel K; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases.; We have recently demonstrated that coexpression of Vpu and CD4 in HeLa cells results in the degradation of CD4 in the endoplasmic reticulum. The sensitivity of CD4 to Vpu-mediated degradation is conferred by the presence of specific sequences located between amino acids 402 and 420 in the CD4 cytoplasmic domain. Using
Encapsidation of poliovirus replicons encoding the complete human immunodeficiency virus type 1 gag gene by using a complementation system which provides the P1 capsid protein in trans.: J Virol. 1995 Mar;69(3):1548-55. Unique Identifier : AIDSLINE MED/95156580; Porter DC; Ansardi DC; Morrow CD; Department of Microbiology, University of Alabama at Birmingham; 35294.; Poliovirus genomes which contain small regions of the human immunodeficiency virus type 1 (HIV-1) gag, pol, and env genes substituted in frame for the P1 capsid region replicate and express HIV-1 proteins as fusion proteins with the P1 capsid precursor protein upon transfection into cells (W. S. Choi, R. Pal-Ghosh, an
Reactivation of human immunodeficiency virus type 2 in macaques after simian immunodeficiency virus SIVmac superinfection.: J Virol. 1995 Mar;69(3):1564-74. Unique Identifier : AIDSLINE MED/95156582; Petry H; Dittmer U; Stahl-Hennig C; Coulibaly C; Makoschey B; Fuchs D; Wachter H; Tolle T; Morys-Wortmann C; Kaup FJ; et al; Department of Virology and Immunology, German Primate Centre,; Gottingen.; By superinfection of human immunodeficiency virus type 2 (HIV-2) strain HIV-2ben-infected macaques with simian immunodeficiency virus (SIV) strain SIVmac, we investigated the mutual influences of an apathogenic and a pathogenic virus in vivo. Four rhesus and two cynomolgus monkeys were infected with HIV-2ben in 1988 a
Use of a human immunodeficiency virus type 1 Rev mutant without nucleolar dysfunction as a candidate for potential AIDS therapy.: J Virol. 1995 Mar;69(3):1591-9. Unique Identifier : AIDSLINE MED/95156585; Furuta RA; Kubota S; Maki M; Miyazaki Y; Hattori T; Hatanaka M; Department of Molecular Virology, Kyoto University, Japan.; Applications of transdominant mutants of human immunodeficiency virus type 1 (HIV-1) regulatory proteins, especially Rev mutant, have been attempted for gene therapy against AIDS, because the Rev protein is essential for viral replication. We have previously reported that a mutant Rev protein (dRev) lacking its nucleo
Sanctuary growth of human immunodeficiency virus in the presence of 3'-azido-3'-deoxythymidine.: J Virol. 1995 Mar;69(3):1606-11. Unique Identifier : AIDSLINE MED/95156587; Medina DJ; Tung PP; Lerner-Tung MB; Nelson CJ; Mellors JW; Strair RK; Cancer Institute of New Jersey, Robert Wood Johnson School of; Medicine, University of Medicine and Dentistry of New Jersey,; Piscataway 08854.; Human immunodeficiency virus (HIV) resistance to the nonnucleoside reverse transcriptase inhibitors emerges very rapidly under selection in culture and in patients. In contrast, zidovudine (3 -azido-3 -deoxythymidine [ AZT ])-resistant HIV generally eme
Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor.: J Virol. 1995 Mar;69(3):1612-20. Unique Identifier : AIDSLINE MED/95156588; Herrmann CH; Rice AP; Division of Molecular Virology, Baylor College of Medicine,; Houston, Texas 77030-3498.; Efficient replication of human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) requires the virus transactivator proteins known as Tat. In order to understand the molecular mechanisms involved in Tat transactivation, it is essential to identify the cellular target(s) of the Tat activation domain. Using an in vi
Differential effects of human cytomegalovirus on integrated and unintegrated human immunodeficiency virus sequences.: J Virol. 1995 Mar;69(3):1645-51. Unique Identifier : AIDSLINE MED/95156592; Koval V; Jault FM; Pal PG; Moreno TN; Aiken C; Trono D; Spector SA; Spector DH; Department of Biology, University of California, San Diego, La; Jolla 92093-0116.; Human cytomegalovirus (HCMV) has been implicated as a potential cofactor in human immunodeficiency virus type 1 (HIV-1)-related disease. Previously, we reported that HCMV inhibits HIV-1 RNA and protein synthesis in cells productively infected with both viruses but, in transient ass
V3-independent determinants of macrophage tropism in a primary human immunodeficiency virus type 1 isolate.: J Virol. 1995 Mar;69(3):1755-61. Unique Identifier : AIDSLINE MED/95156606; Kim FM; Kolson DL; Balliet JW; Srinivasan A; Collman RG; Department of Medicine, University of Pennsylvania School of; Medicine, Philadelphia 19104-6076.; Human immunodeficiency virus type 1 isolates differ in their ability to productively infect macrophages, and several groups have mapped the genetic basis for macrophage tropism to regions of env that include the third hypervariable region (V3 loop). We recently described a primary isolate (89.6) which is highly macrop
The central globular domain of the nucleocapsid protein of human immunodeficiency virus type 1 is critical for virion structure and infectivity.: J Virol. 1995 Mar;69(3):1778-84. Unique Identifier : AIDSLINE MED/95156609; Ottmann M; Gabus C; Darlix JL; LaboRetro, Unite de Virologie Humaine, Ecole Normale; Superieure-Institut National de la Sante et de la Recherche; Medicale, Lyon, France.; The nucleocapsid protein NCp7 of human immunodeficiency virus type 1 (HIV-1) is a 72-amino-acid peptide containing two CCHC-type zinc fingers linked by a short basic sequence, 29RAPRKKG35, which is conserved in HIV-1 and simian immunodeficiency virus. The complete three-dimensional structure of NCp7 has been determine
Sequence-specific inhibition of gene expression by a novel antisense oligodeoxynucleotide phosphorothioate directed against a nonregulatory region of the human immunodeficiency virus type 1 genome.: J Virol. 1995 Mar;69(3):1794-801. Unique Identifier : AIDSLINE MED/95156611; Anazodo MI; Wainberg MA; Friesen AD; Wright JA; Manitoba Institute of Cell Biology, University of Manitoba,; Winnipeg, Canada.; Previous studies have demonstrated that oligodeoxynucleotide phosphorothioates complementary to human immunodeficiency virus type 1 (HIV-1) RNA are more nuclease resistant and are effective inhibitors of HIV-1 replication than their unmodified counterpart. In this study, antisense oligodeoxynucleotide sequences were e
Syncytium-inducing (SI) phenotype suppression at seroconversion after intramuscular inoculation of a non-syncytium-inducing/SI phenotypically mixed human immunodeficiency virus population.: J Virol. 1995 Mar;69(3):1810-8. Unique Identifier : AIDSLINE GENBANK/Z47540; Cornelissen M; Mulder-Kampinga G; Veenstra J; Zorgdrager F; Kuiken C; Hartman S; Dekker J; van der Hoek L; Sol C; Coutinho R; et al; Human Retrovirus Laboratory, Academic Medical Centre, Amsterdam,; The Netherlands.; Two distinct biological phenotypes of human immunodeficiency virus (HIV) have been described: the non-syncytium-inducing (NSI) phenotype, best characterized by the inability to infect MT-2 cells, and the syncytium-inducing (SI) phenotype, with the ability to infect MT-2 cells. The earliest virus population observed fo
Definition of a minimal activation domain in human T-cell leukemia virus type I Tax.: J Virol. 1995 Mar;69(3):1827-33. Unique Identifier : AIDSLINE MED/95156615; Semmes OJ; Jeang KT; Molecular Virology Section, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.; Fourteen mutants were used to delineate a minimal activation domain in the Tax protein of human T-cell leukemia virus type I. In an assay using a Gal4-Tax (GalTx) fusion protein and a responsive promoter containing Gal4 consensus binding sites, we found that activation was squelched by coexpression of wild-type Tax pr
Distinct regions in human T-cell lymphotropic virus type I tax mediate interactions with activator protein CREB and basal transcription factors.: J Virol. 1995 Mar;69(3):1834-41. Unique Identifier : AIDSLINE MED/95156616; Adya N; Giam CZ; Department of Medicine, Case Western Reserve University,; Cleveland, Ohio 44106.; Human T-cell lymphotropic virus type I (HTLV-I) transactivator Tax augments transcription from three (cyclic AMP response element (CRE)-containing 21-bp repeats in the viral long terminal repeat and several other cis regulatory elements, including the NF-kappa B binding sites and the serum response element. Tax does n
Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.: J Virol. 1995 Mar;69(3):1842-50. Unique Identifier : AIDSLINE MED/95156617; Greenway A; Azad A; McPhee D; AIDS Cellular Biology Unit, National Centre in HIV Virology; Research, Macfarlane Burnet Centre for Medical Research,; Fairfield, Victoria, Australia.; Human immunodeficiency virus type 1 (HIV-1) Nef protein causes the loss of cell surface CD4 and interleukin-2 ( IL-2 ) receptor (Tac) from peripheral blood mononuclear cells (PBMC) and CD4+ T-cell lines. As both CD4 and the IL-2 receptor play crucial roles in antigen-dri
Spontaneous reversion of human immunodeficiency virus type 1 neutralization-resistant variant HXB2thr582: in vitro selection against cytopathicity highlights gp120-gp41 interactive regions.: J Virol. 1995 Mar;69(3):1860-7. Unique Identifier : AIDSLINE MED/95156619; Stern TL; Reitz MS Jr; Robert-Guroff M; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892-4255.; Spontaneous revertants of the immune-selected variant HXB2thr582, which resists neutralization by certain conformationally dependent antibodies specific for the CD4-binding site on gp120 (such as F105), appeared after long-term culture in the absence of immune-selecting serum. Molecular analysis showed some of the vir
Human immunodeficiency virus type 1 cellular RNA load and splicing patterns predict disease progression in a longitudinally studied cohort.: J Virol. 1995 Mar;69(3):1868-77. Unique Identifier : AIDSLINE MED/95156620; Michael NL; Mo T; Merzouki A; O'Shaughnessy M; Oster C; Burke DS; Redfield RR; Birx DL; Cassol SA; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland.; We report the results of a longitudinal study of RNA splicing patterns in 31 early-stage human immunodeficiency virus disease patients with an average follow-up time of 3 years. Eighteen patients showed no evidence for disease progression, whereas 13 patients either showed a > or = 50% reduction in baseline CD4 count
Infection by retroviral vectors outside of their host range in the presence of replication-defective adenovirus.: J Virol. 1995 Mar;69(3):1887-94. Unique Identifier : AIDSLINE MED/95156622; Adams RM; Wang M; Steffen D; Ledley FD; Department of Cell Biology, Baylor College of Medicine, Houston,; Texas 77030.; Retrovirus infection is normally limited to cells within a specific host range which express a cognate receptor that is recognized by the product of the env gene. We describe retrovirus infection of cells outside of their normal host range when the infection is performed in the presence of a replication-defective aden
Virions released from cells transfected with a molecular clone of human T-cell leukemia virus type I give rise to primary and secondary infections of T cells.: J Virol. 1995 Mar;69(3):1907-12. Unique Identifier : AIDSLINE MED/95156625; Derse D; Mikovits J; Polianova M; Felber BK; Ruscetti F; Laboratory of Leukocyte Biology, National Cancer; Institute-Frederick Cancer Research and Development Center,; Maryland 21702-1201.; The ability of molecular clones of human T-cell leukemia virus type I (HTLV-I) to direct the synthesis of infectious virions has not previously been demonstrated. An HTLV-I provirus originating from an adult T-cell leukemia patient was cloned into a plasmid vector and is designated pCS-HTLV. This molecular clone was s
Genetically simpler bovine leukemia virus derivatives can replicate independently of Tax and Rex.: J Virol. 1995 Mar;69(3):1920-4. Unique Identifier : AIDSLINE MED/95156628; Boris-Lawrie K; Temin HM; McArdle Laboratory for Cancer Research, University of Wisconsin; Medical School, Madison.; Retrovirus genomes have a conserved modular organization that consists of trans-acting gag, pol, and env genes that function through cis-acting sequences to replicate the RNA genome to the DNA provirus. Genetically more complex retroviruses also encode regulatory genes and cis-acting sequences that are essential for t
Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency virus type 1 matrix.: J Virol. 1995 Mar;69(3):1984-9. Unique Identifier : AIDSLINE MED/95156639; Freed EO; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892-0460.; Incorporation of envelope glycoproteins into a budding retrovirus is an essential step in the formation of an infectious virus particle. By using site-directed mutagenesis, we identified specific amino acid residues in the matrix domain of the human immunodeficiency virus type 1 (HIV-1) Gag protein that are critical t
From the Centers for Disease Control and Prevention. Update: acquired immunodeficiency syndrome--United States, 1994.: JAMA. 1995 Mar 1;273(9):692. Unique Identifier : AIDSLINE MED/95156712
Human T-cell lymphotropic virus type I-associated adult T-cell leukemia. The Joseph Goldberger Clinical Investigator Lecture [clinical conference]: JAMA. 1995 Mar 1;273(9):735-7. Unique Identifier : AIDSLINE MED/95156734; Waldmann TA; Metabolism Branch, National Cancer Institutes, National; Institutes of Health, Bethesda, Md 20892.
Contribution of ED-1- and CD-8-positive cells to the development of crescentic-type anti-GBM nephritis in rats.: Nippon Jinzo Gakkai Shi. 1994 Nov;36(11):1228-39. Unique Identifier : AIDSLINE MED/95156857; Hattori T; Nagamatsu T; Ito M; Suzuki Y; Department of Pharmacology, Faculty of Pharmacy, Meijo; University, Nagoya, Japan.; The current studies were designed to identify which mononuclear leukocytes have an important role in the development of glomerular injury using rats with original-type (mild injury) and crescentic-type (severe injury) anti-glomerular basement membrane (GBM) nephritis. 1) Proteinuria was persistent in crescentic-type a
Acute renal failure in the setting of bone marrow transplantation.: Kidney Int. 1994 Nov;46(5):1443-58. Unique Identifier : AIDSLINE MED/95156911; Zager RA; Fred Hutchinson Cancer Research Center, University of Washington,; Seattle.
[Explosive themes--creative models]: Krankenpfl Soins Infirm. 1995 Jan;88(1):13-5. Unique Identifier : AIDSLINE MED/95156939; Bischofberger I
Gene therapy and immune restoration for HIV disease.: Lancet. 1995 Feb 18;345(8947):427-32. Unique Identifier : AIDSLINE MED/95157074; Bridges SH; Sarver N; Targeted Interventions Branch, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892-7620.
Exacerbation of peripheral neuropathy by lamivudine [letter]: Lancet. 1995 Feb 18;345(8947):460-1. Unique Identifier : AIDSLINE MED/95157105; Cupler EJ; Dalakas MC
Stability of dimeric retroviral proteases.: Methods Enzymol. 1994;241:104-27. Unique Identifier : AIDSLINE MED/95157306; Darke PL; Biological Chemistry Department, Merck Research Laboratories,; West Point, Pennsylvania 19486.; The determination of dimer stabilities for the retroviral proteases has proved more challenging than anticipated, but it is a tractable problem when careful attention is made to potential interferences. For investigations of retroviral proteases not yet characterized, the fundamentally rigorous sedimentation equilibri
Use of steady state kinetic methods to elucidate the kinetic and chemical mechanisms of retroviral proteases.: Methods Enzymol. 1994;241:127-56. Unique Identifier : AIDSLINE MED/95157307; Meek TD; Rodriguez EJ; Angeles TS; Department of Cardiovascular Biochemistry, Bristol-Myers Squibb; Pharmaceutical Research Institute, Princeton, New Jersey 08540.; Despite the current plethora of structural data of HIV-1 protease and the availability of potent inhibitors, whose structures are based in part on the presumed mechanism of action of this enzyme, our actual understanding of its chemical mechanism has been until now based largely on the precedents of the mammalian and
X-ray structures of retroviral proteases and their inhibitor-bound complexes.: Methods Enzymol. 1994;241:157-77. Unique Identifier : AIDSLINE MED/95157308; Ringe D; Rosenstiel Basic Medical Sciences Research Center, Brandeis; University, Waltham, Massachusetts 02254.
Genetic approaches designed to minimize cytotoxicity of retroviral protease.: Methods Enzymol. 1994;241:16-29. Unique Identifier : AIDSLINE MED/95157309; Rizzo CJ; Korant BD; Virus Laboratory, DuPont Merck Company, Glenolden, Pennsylvania; 19036.
Probing structure-function relationships in human immunodeficiency virus type 1 protease via molecular dynamics simulation.: Methods Enzymol. 1994;241:178-95. Unique Identifier : AIDSLINE MED/95157310; Harte WE Jr; Beveridge DL; Bristol-Myers Squibb, Pharmaceutical Research Institute,; Wallingford, Connecticut 06492.; This chapter has focused on the application of molecular dynamics computer simulations and related molecular modeling techniques to the study of HIV protease structure and structure-function relationships. The abundance of crystallographic data provides ample experimental quantities (average structures, temperature fa
Relationships of human immunodeficiency virus protease with eukaryotic aspartic proteases.: Methods Enzymol. 1994;241:195-224. Unique Identifier : AIDSLINE MED/95157311; Lin XL; Lin YZ; Tang J; Oklahoma Medical Research Foundation, Oklahoma City 73104.
Processing of retroviral Gag polyproteins: an in vitro approach.: Methods Enzymol. 1994;241:227-53. Unique Identifier : AIDSLINE MED/95157312; Carter C; Zybarth G; Stonybrook Health Sciences Center, Department of Microbiology,; State University of New York at Stonybrook 11794.
Subsite preferences of retroviral proteinases.: Methods Enzymol. 1994;241:254-78. Unique Identifier : AIDSLINE MED/95157313; Dunn BM; Gustchina A; Wlodawer A; Kay J; Department of Biochemistry and Molecular Biology, University of; Florida College of Medicine, Gainesville 32610.
Specificity of retroviral proteases: an analysis of viral and nonviral protein substrates.: Methods Enzymol. 1994;241:279-301. Unique Identifier : AIDSLINE MED/95157314; Tomasselli AG; Heinrikson RL; Biochemistry Unit, Upjohn Laboratories, Kalamazoo, Michigan; 49001.
Host strain selection for bacterial expression of toxic proteins.: Methods Enzymol. 1994;241:29-46. Unique Identifier : AIDSLINE MED/95157315; Chen E; Department of Biological Chemistry, Merck Research Laboratories,; West Point, Pennsylvania 19486.
Expression systems for retroviral proteases.: Methods Enzymol. 1994;241:3-16. Unique Identifier : AIDSLINE MED/95157316; Stebbins J; Debouck C; Department of Molecular Genetics, Smihkline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406.
Design of tight-binding human immunodeficiency virus type 1 protease inhibitors.: Methods Enzymol. 1994;241:311-34. Unique Identifier : AIDSLINE MED/95157318; Vacca JP; Department of Medical Chemistry, Merck Research Laboratories,; West Point, Pennsylvania 19486.
Design of symmetry-based, peptidomimetic inhibitors of human immunodeficiency virus protease.: Methods Enzymol. 1994;241:334-54. Unique Identifier : AIDSLINE MED/95157319; Kempf DJ; Pharmaceutical Products Division, Abott Laboratories, Abott Park,; Illinois 60064.
Advances in automated docking applied to human immunodeficiency virus type 1 protease.: Methods Enzymol. 1994;241:354-70. Unique Identifier : AIDSLINE MED/95157320; Miller MD; Sheridan RP; Kearsley SK; Underwood DJ; Department of Molecular Systems, Merck Research Laboratories,; West Point, Pennsylvania 19486.
Use of molecular dynamics and free energy perturbation calculations in anti-human immunodeficiency virus drug design.: Methods Enzymol. 1994;241:370-84. Unique Identifier : AIDSLINE MED/95157321; McCarrick MA; Kollman P; Department of Pharmaceutical Chemistry, School of Pharmacy,; University of California, San Francisco 94143.
Qualitative study of drug resistance in retroviral protease using structural modeling and site-directed mutagenesis.: Methods Enzymol. 1994;241:385-94. Unique Identifier : AIDSLINE MED/95157322; Culberson JC; Bush BL; Sardana VV; Department of Molecular Systems, Merck Research Laboratories,; West Point, Pennsylvania 19486.
Analysis of human immunodeficiency virus type 1 protease activity in eukaryotic and bacterial cells.: Methods Enzymol. 1994;241:58-69. Unique Identifier : AIDSLINE MED/95157324; Kaplan AH; Manchester M; Everitt L; Swanstrom R; Department of Medicine, UNC Lineberger Comprehensive Cancer; Center, University of North Carolina at Chapel Hill 27599.
Synthetic approaches to continuous assays of retroviral proteases.: Methods Enzymol. 1994;241:70-86. Unique Identifier : AIDSLINE MED/95157325; Krafft GA; Wang GT; Department of Structural Biology, Drug Design and Delivery,; Abbott Laboratories, Abbott Park, Illinois 60064.; This chapter has described a number of approaches for continuous assay of retroviral proteases using either chromogenic or fluorogenic synthetic substrates. The significant progress in this area has been catalyzed by the intense interest in HIV protease as a therapeutic target, but these versatile methods will be used
Identification, purification, and cell culture assays of retroviral proteases.: Methods Enzymol. 1994;241:89-104. Unique Identifier : AIDSLINE MED/95157326; von der Helm K; Seelmeier S; Kisselev A; Nitschko H; Max von Petenkofer-Institut fur Hygiene und Medizinische; Mikrobiologie der Ludwig-Maximilians-Universitat, Munchen,; Germany.
EEG diagnostic and predictive value on HIV infection in childhood.: Neurophysiol Clin. 1994 Nov;24(5):367-79. Unique Identifier : AIDSLINE MED/95157394; Vigliano P; Rigardetto R; Capizzi G; Arfelli P; Barbicinti I; Boffi P; Bonassi E; Cavallo P; Crosa P; Gandione M; et al; University of Turin, Cattedra di Neuropsichiatria Infantile,; Italy.; This prospective study evaluated the electroencephalographic (EEG) diagnostic and prognostic value in childhood HIV infection. It was carried out on 125 subjects and included all Piemonte s seropositive children. The EEG was repeated every three months during the first 15 months of life, and then, at least, annually i
[Pathogenesis, immunobiology and epidemiology of cryptococcosis]: Mycoses. 1994;37 Suppl 1:34-42. Unique Identifier : AIDSLINE MED/95157576; Muller J; Sektion Mykologie, Institut fur Medizinische Mikrobiologie und; Hygiene, Universitat Freiburg.; Cryptococcus neoformans is taken up by the human host via the respiratory tract. The polysaccharide capsule is regarded as the pathogenetic principle inhibiting phagocytosis of the fungus by cells of the unspecific host defense. Unspecific opsonization of Cr. n. by early phase proteins causes a rapid and successful el
[Correlation between resistance testing and typing of Candida albicans--isolates from AIDS patients and chronic recurrent oral candidiasis]: Mycoses. 1994;37 Suppl 1:60-3. Unique Identifier : AIDSLINE MED/95157580; Ruhnke M; Tennagen I; Engelmann E; Universitatsklinikum Rudolf Virchow/Charlottenburg, Medizinische; Klinik und Poliklinik, FU Berlin.; In patients with AIDS and recurrent oropharyngeal candidosis results of biotyping and serotyping were compared with antifungal susceptibility testing. Biotype B1 was found predominantly with 44.3% from 169 C. albicans isolates. Serotype A was seen in 150/169 C. albicans isolates. No close correlation between high MIC
[Fluconazole sensitivity of Candida strains in vitro in the microdilution test and agar diffusion test]: Mycoses. 1994;37 Suppl 1:64-70. Unique Identifier : AIDSLINE MED/95157581; Metzger S; Jager H; Hofmann H; Dermatologische Klinik und Poliklinik der Technischen; Universitat, Munchen.; The comparison of the in vitro-susceptibility of Candida isolates collected from the oral cavity of different groups of patients to fluconazole ist reported. The isolates of HIV-patients treated with fluconazole, HIV-patients and dermatological patients without fluconazole exposure were investigated. The in vitro-susc
A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection. NIAID AIDS Clinical Trials Group [see comments]: N Engl J Med. 1995 Mar 16;332(11):693-9. Unique Identifier : AIDSLINE MED/95157587; Bozzette SA; Finkelstein DM; Spector SA; Frame P; Powderly WG; He W; Phillips L; Craven D; van der Horst C; Feinberg J; University of California, San Diego, La Jolla.; BACKGROUND. We evaluated the effectiveness of three treatment strategies for the prevention of a first episode of Pneumocystis carinii pneumonia in patients infected with the human immunodeficiency virus (HIV). METHODS. In an open-label trial, 843 patients with HIV infection and fewer than 200 CD4+ cells per cubic mil
A randomized trial comparing fluconazole with clotrimazole troches for the prevention of fungal infections in patients with advanced human immunodeficiency virus infection. NIAID AIDS Clinical Trials Group [see comments]: N Engl J Med. 1995 Mar 16;332(11):700-5. Unique Identifier : AIDSLINE MED/95157588; Powderly WG; Finkelstein D; Feinberg J; Frame P; He W; van der Horst C; Koletar SL; Eyster ME; Carey J; Waskin H; et al; Washington University School of Medicine, St. Louis.; BACKGROUND. Cryptococcal meningitis and other serious fungal infections are common complications in patients infected with the human immunodeficiency virus (HIV). Fluconazole is effective for long-term suppression of many fungal infections, but its effectiveness as p
The cost effectiveness of preoperative autologous blood donations [see comments]: N Engl J Med. 1995 Mar 16;332(11):719-24. Unique Identifier : AIDSLINE MED/95157592; Etchason J; Petz L; Keeler E; Calhoun L; Kleinman S; Snider C; Fink A; Brook R; Division of General Internal Medicine, West Los Angeles Veterans; Affairs Medical Center, CA 90073.; BACKGROUND. Since the recognition that human immunodeficiency virus is transmissible by blood transfusion there has been increasing public and professional support for autologous blood donations before elective surgery. Autologous blood donation is, however, a more expensive process than the donation of allogeneic blo
Primary prophylaxis against opportunistic infections in patients with AIDS [editorial; comment]: N Engl J Med. 1995 Mar 16;332(11):739-40. Unique Identifier : AIDSLINE MED/95157595; Clumeck N
Autologous blood donation--can we bank on it? [editorial; comment]: N Engl J Med. 1995 Mar 16;332(11):740-2. Unique Identifier : AIDSLINE MED/95157596; Rutherford CJ; Kaplan HS
Prophylactic immune globulin in children with HIV disease [letter; comment]: N Engl J Med. 1995 Mar 16;332(11):750-2. Unique Identifier : AIDSLINE MED/95157604; Mofenson LM; Nugent R
France's blood scandal [editorial] [see comments]: Nature. 1995 Feb 16;373(6515):546. Unique Identifier : AIDSLINE MED/95157612
Blood transfusion chief is refused parole [news]: Nature. 1995 Feb 16;373(6515):550. Unique Identifier : AIDSLINE MED/95157614; Butler D
Meeting the challenge of HIV [letter; comment]: N C Med J. 1994 Dec;55(12):576. Unique Identifier : AIDSLINE MED/95157679; Kanof EP
[Clinical effectiveness of zidovudine]: Ned Tijdschr Geneeskd. 1995 Feb 4;139(5):211-3. Unique Identifier : AIDSLINE MED/95157698; Mulder JW; Slotervaartziekenhuis, afd. Interne Geneeskunde, Amsterdam.
Neurologic signs and symptoms in a cohort of homosexual men followed for 4.5 years.: Neurology. 1995 Feb;45(2):261-7. Unique Identifier : AIDSLINE MED/95157743; Marder K; Liu X; Stern Y; Dooneief G; Bell K; Schofield P; Sacktor N; Todak G; Friedman R; Ehrhardt A; et al; Department of Neurology, College of Physicians and Surgeons,; Columbia University, New York, NY.; We traced the development of neurologic impairment in 207 homosexual men (123 human immunodeficiency virus [HIV]-positive and 84 HIV-negative controls) over 4.5 years of follow-up. We applied generalized estimating equations to logistic regression analyses with repeated measures to examine the differences between HIV-
Cognitive performance after progression to AIDS: a longitudinal study from the Multicenter AIDS Cohort Study.: Neurology. 1995 Feb;45(2):267-75. Unique Identifier : AIDSLINE MED/95157744; Selnes OA; Galai N; Bacellar H; Miller EN; Becker JT; Wesch J; Van Gorp W; McArthur JC; Johns Hopkins University, Baltimore, MD.; OBJECTIVE: To describe changes in cognitive functioning before and after development of an acquired immune deficiency syndrome (AIDS)-defining illness or CD4+ lymphocyte count
Cataplexy associated with midbrain lesion.: Neurology. 1995 Feb;45(2):393-4. Unique Identifier : AIDSLINE MED/95157772; Fernandez JM; Sadaba F; Villaverde FJ; Alvaro LC; Cortina C; Neurology Service, Hospital de Basurto, Bilbao, Spain.
Dealing with H.I.V.-related pulmonary infections.: Nursing. 1994 Nov;24(11):60-4. Unique Identifier : AIDSLINE MED/95157931; Anastasi JK; Thomas F
Workers' compensation. Coverage for H.I.V.: Nursing. 1994 Sep;24(9):78. Unique Identifier : AIDSLINE MED/95157989
[Adherence of isolated Candida albicans strains from HIV+ infected patients to buccal epithelial cells: correlation with serotype, sensitivity to fluconazole and virulence]: Pathol Biol (Paris). 1994 Jun;42(6):567-73. Unique Identifier : AIDSLINE MED/95158093; Imbert-Bernard C; Valentin A; Reynes J; Mallie M; Bastide JM; Laboratoire de Parasitologie-Immunologie, UFR des Sciences; Pharmaceutiques, Faculte de Pharmacie, Montpellier, France.; During infection by human immunodeficiency virus (HIV), oral pseudomembranous candidiasis frequency is high. Adherence of Candida albicans to epithelial cells constitutes one of the first step in the setting up of candidiasis. Adherence ability of Candida albicans to buccal epithelial cells (BEC) is estimated for 83 i
[Transmission of hepatitis C virus from mother to infant]: Pathol Biol (Paris). 1994 Jun;42(6):593-601. Unique Identifier : AIDSLINE MED/95158097; Martin PH; Denis F; Departement de Bacteriologie-Virologie, CHU Dupuytren, Limoges,; France.; The transmission of hepatitis C virus (VHC) by percutaneous exposure to blood contamination is well documented but account for only 50 to 60% of hepatitis C cases. The transmission route for sporadic cases remains controversial and transmission by sexual contact and vertical transmission have been implicated. Antibodi
Increased soluble CD8 (sCD8) in human immunodeficiency virus 1-infected children in the first month and year of life.: Pediatr Infect Dis J. 1994 Oct;13(10):896-8. Unique Identifier : AIDSLINE MED/95158128; Gesner M; Di John D; Krasinski K; Borkowsky W; Department of Pediatrics, New York University Medical Center, NY; 10016.; The purpose of this study was to determine whether soluble CD8 (sCD8) in serum of perinatally human immunodeficiency virus 1 (HIV-1)-infected children during the first year of life differs from that of HIV-1-uninfected control children. Soluble CD8 concentrations in stored plasma and serum samples of children of HIV-1
A blueprint for care, treatment, and prevention of HIV/AIDS in children.: Pediatr Infect Dis J. 1994 Oct;13(10):920-3. Unique Identifier : AIDSLINE MED/95158131; Wilfert CM; Pizzo PA; Department of Pediatrics, Duke University Medical Center, Durham,; NC.
Impaired immunity to pneumococcal polysaccharide antigens in children with human immunodeficiency virus infection immunized with pneumococcal vaccine.: Pediatr Infect Dis J. 1994 Oct;13(10):933-4. Unique Identifier : AIDSLINE MED/95158135; Peters VB; Diamant EP; Hodes DS; Cimino CO; Department of Pediatrics, Mount Sinai School of Medicine, New; York, NY.
[Panorama of infections among refugees--the risk of epidemics from the East]: Nord Med. 1995;110(2):40-1, 47. Unique Identifier : AIDSLINE MED/95158145; Christenson B; Miljomedicinska enheten, Karolinska sjukhuset, Stockholm.; The article consists in an account of the numbers of reported cases of infectious diseases among approximately 10,000 refugees who came to the Stockholm area, primarily from the former Yugoslavia, Africa, Asia and Irak during the period 1992-1993. High prevalences were noted of hepatitis B and tuberculosis, and in cer
Thrombotic thrombocytopenic purpura as the cause of death in an HIV-positive child.: Pediatr Pathol. 1994 Nov-Dec;14(6):919-25. Unique Identifier : AIDSLINE MED/95158257; Jorda M; Rodriguez MM; Reik RA; University of Miami/Jackson Memorial Hospital, Department of; Pathology, Florida.; A case of fatal thrombotic thrombocytopenic purpura (TTP) in a pediatric patients with HIV infection is reported. The diagnosis was made at autopsy based on the presence of platelet microthrombi in multiple organs, including the cardiac conduction system. The disease presented atypically with hemorrhagic manifestation
Acanthamoeba-specific human T-cell clones isolated from healthy individuals.: Parasitol Res. 1994;80(7):549-53. Unique Identifier : AIDSLINE MED/95158365; Tanaka Y; Suguri S; Harada M; Hayabara T; Suzumori K; Ohta N; Department of Parasitology, Okayama University Medical School,; Japan.; T-cell responses to pathogenic free-living amoebae, Acanthamoeba sp., were analyzed in healthy Japanese individuals. Of 20 healthy subjects, 10 (50%) showed significant proliferative responses of peripheral blood mononuclear cells to the soluble amoebic antigens in vitro. The antigens used were not mitogenic, and no e
Gear future training to practitioners' needs. Attitudes towards intravenous drug users.: Prof Nurse. 1995 Jan;10(4):215-9. Unique Identifier : AIDSLINE MED/95158403; Carroll J; 1. There is no clear-cut relationship between staff knowledge and their attitudes to HIV and Aids. 2. Perceptions of service delivery to drug users are likely to be affected by respondents occupational backgrounds. 3. The effectiveness of service delivery is likely to be affected by situational constraints. 4. There
The relationship of infectious agents to inflammatory myositis.: Rheum Dis Clin North Am. 1994 Nov;20(4):995-1015. Unique Identifier : AIDSLINE MED/95158606; Ytterberg SR; Veterans Affairs Medical Center, Minneapolis, Minnesota.; Several infectious agents have been linked to chronic inflammatory myositis. The mechanisms proposed usually involve presumed persistent infection or induction of an autoimmune response following infection. Agents most often implicated are the enteroviruses (especially coxsackieviruses), echoviruses in patients with a
[Fatal visceral leishmaniasis associated with acquired immunodeficiency syndrome: report of a case with necropsy findings and immunohistochemical study]: Rev Soc Bras Med Trop. 1994 Oct-Dec;27(4):245-50. Unique Identifier : AIDSLINE MED/95158643; Ramos CC; Duarte MI; Ramos AM; Servico de Verificacao de Obitos do Estado do Rio Grande,; Natal.; A case of fatal visceral leishmaniasis associated with immunodeficiency syndrome in a 32 year-old male patient is reported. The protozoonosis was responsible for the patient s death. Visceral leishmaniasis showed itself in an atypical form, at necropsy, with an intense parasitation of the mononuclear phagocitic system
[Intestinal mycobacterial infections in AIDS. Clinical course and treatment of infections caused by Mycobacterium avium, Mycobacterium kansasii, Mycobacterium genavense]: Recenti Prog Med. 1994 Nov;85(11):526-36. Unique Identifier : AIDSLINE MED/95158661; Dionisio D; Tortoli E; Simonetti MT; di Lollo S; Meli M; Farese A; Fontana R; Sterrantino G; Leoncini F; U.O. Malattie Infettive, Ospedale di Careggi, Firenze.; Digestive apparatus is a common target of atypical mycobacteriosis in AIDS patients (at least 50% of patients with CD4+ lymphocytes
A direct, general approach based on isobolograms for assessing the joint action of drugs in pre-clinical experiments.: Stat Med. 1994 Nov 30;13(22):2289-309. Unique Identifier : AIDSLINE MED/95158741; Machado SG; Robinson GA; Division of Biometrics, Food and Drug Administration, Rockville,; MD 20857.; Pharmacologists and other biologists frequently use methods based on the interpretation of isobolograms to quantify the extent of synergy or antagonism between drugs used in combination in pre-clinical studies. Most methods have been unsatisfactory from a statistical viewpoint, many because they have relied solely on
Age-related reference ranges: significance tests for models and confidence intervals for centiles.: Stat Med. 1994 Nov 30;13(22):2359-67. Unique Identifier : AIDSLINE MED/95158746; Wade AM; Ades AE; Department of Epidemiology and Biostatistics, Institute of Child; Health, London, U.K.; A method of fitting age-related reference ranges using maximized likelihood is presented. The method is illustrated using CD4 counts of uninfected children born to HIV-1 infected women. The likelihood incorporates exponential functions to describe the Box-Cox transformation parameter that induces Normality and the mea
[Comparison between CSF samples from AIDS and non AIDS patients with neurocryptococcosis]: Rev Inst Med Trop Sao Paulo. 1994 May-Jun;36(3):225-30. Unique Identifier : AIDSLINE MED/95158763; dos Reis-Filho JB; Matas SL; Fischman O; Morales BC; Juliano Y; Setor de Liquido Cefalorraquiano-Escola Paulista de Medicina,; Sao Paulo/SP, Brasil.; Neurocryptococcosis was a rare nervous system infection. With the rising number of patients with AIDS it became a very frequent disease. This infection is supposed to infect patients with some kind of immunodeficiency and the CSF alterations often simulate tuberculous meningitis. The purpose of this research was to co
[Difficulties in diagnosing atypical primary HIV-1 infection: report of a case]: Rev Inst Med Trop Sao Paulo. 1994 May-Jun;36(3):287-92. Unique Identifier : AIDSLINE MED/95158772; Casseb JS; Caterino-de-Araujo A; Medico Infectologista, Instituto de Infectologia Emilio Ribas,; Sao Paulo, SP, Brasil.; Several cases of primary HIV-1 infection are not identified, either because the diagnosis is not suspected or because they test negative for HIV-1 antibody. This work presents an uncommon case of primary HIV-1 infection in an young parenteral drug abuser man, who presented symptoms of acute hepatitis. During the initi
HIV-seropositive rate and HIV test activity among STD clinic attendees in Bergen, Norway.: Scand J Infect Dis. 1994;26(5):511-6. Unique Identifier : AIDSLINE MED/95158825; Tveit KS; Nyfors A; Nilsen A; Department of Dermatology, Haukeland University Hospital, Bergen,; Norway.; We wanted to determine the HIV seropositive rate and to study the connection between previous HIV testing, acceptance of HIV testing and sexual behaviour among STD clinic patients in Bergen, Norway . Patients attending the STD clinic in 1986-93 requesting HIV testing were registered
Danish AIDS patients 1988-1993: a recent decline in Pneumocystis carinii pneumonia as AIDS-defining disease related to the period of known HIV positivity.: Scand J Infect Dis. 1994;26(5):517-22. Unique Identifier : AIDSLINE MED/95158826; Smith E; Orholm MK; Department of Epidemiology, Statens Seruminstitut, Copenhagen,; Denmark.; The frequency of PCP among adult Danish AIDS patients notified in 1988-93 was higher among patients tested HIV-positive less than 4 months prior to AIDS than among those known to be positive for > 1 year. Among the latter, the proportion with PCP decreased significantly over the period, from 45.3% in 1988 to 22.0% in
Markers of immune stimulation in the cerebrospinal fluid during HIV infection: a longitudinal study.: Scand J Infect Dis. 1994;26(5):523-33. Unique Identifier : AIDSLINE MED/95158827; Gisslen M; Chiodi F; Fuchs D; Norkrans G; Svennerholm B; Wachter H; Hagberg L; Department of Infectious Diseases, University of Goteborg,; Sweden.; Markers of immune stimulation were studied in 76 sequential cerebrospinal fluid (CSF) samples from 19 patients infected with HIV-1 without antiretroviral treatment during observation periods ranging from 22 months to 6 years. Eight of these patients were further followed with 14 CSF samples for 3-24 months of zidovudi
[Artists facing AIDS (news)]: Schweiz Monatsschr Zahnmed. 1995;105(1):137. Unique Identifier : AIDSLINE MED/95158853
[Necrotizing vasculitis of the tongue. A contribution to the differential diagnosis of ulcerative mucosal changes in HIV-infected patients]: Schweiz Monatsschr Zahnmed. 1995;105(1):54-62. Unique Identifier : AIDSLINE MED/95158857; Jurgensen O; Altermatt HJ; von Overbeck J; Berthold H; Klinik fur Oralchirurgie, Universitat Bern.
AIDS-associated Kaposi's sarcoma [letter; comment]: Science. 1995 Feb 24;267(5201):1078-9. Unique Identifier : AIDSLINE MED/95158862; Jones JL; Hanson DL; Chu SY; Ward JW; Jaffe HW
[Possibility for detecting HIV-1 in bone transplant by PCR using the HIV-1 microtiter plate assay]: Unfallchirurg. 1994 Dec;97(12):629-32. Unique Identifier : AIDSLINE MED/95158886; Roder W; Kruse M; Runkel M; Muller WE; Isemer FE; Abteilung fur Allgemein- und Unfallchirurgie, St.; Josefs-Hospital Wiesbaden.; It is known that HIV can be transmitted by allogenous bone transplantation. Hitherto neither chemical nor physical methods have existed to allow reliable disinfection and sterilization of bone specimens without reducing osteogenetic potency. Only demonstration or exclusion of the presence of HIV-1 in a bone specimen g
[Non-Hodgkin's lymphomas in patients with human immunodeficiency virus infections. Clinicopathologic characteristics, treatment response and prognosis in 40 patients]: Sangre (Barc). 1994 Dec;39(6):429-34. Unique Identifier : AIDSLINE MED/95158975; Ribera JM; Navarro JT; Oriol A; Raventos A; Sirera G; Flores A; Vaquero M; Milla F; Feliu E; Servicio de Hematologia, Hospital Universitari Germans Trias i; Pujol, Universidad Autonoma de Barcelona.; BASIS: Non-Hodgkin lymphoma (NHL) is one of the commonest neoplasms appearing in subjects infected by the human immunodeficiency virus (HIV). The purpose of this work was to analyse the clinical and laboratory characteristics, along with the clinical course, response to therapy and prognosis in a series of 40 patients
[Treatment response and long term survival of a patient seropositive for the human immunodeficiency virus with non-Hodgkin's lymphoma (letter)]: Sangre (Barc). 1994 Dec;39(6):496-7. Unique Identifier : AIDSLINE MED/95158984; Ribas A; Felip E; Giralt J; Garcia Bragado F
[Enteropathy induced by clofazimine (Lamprene) in AIDS (letter)]: Therapie. 1994 Sep-Oct;49(5):462-3. Unique Identifier : AIDSLINE MED/95159051; Mondain-Miton V; Chichmanian RM; Dellamonica P
[Desensitization in HIV seropositive patients with cotrimoxazole hypersensitivity. A series of 18 cases (letter)]: Therapie. 1994 Sep-Oct;49(5):463-5. Unique Identifier : AIDSLINE MED/95159052; Amedeo J; Chichmanian RM; Reboulot B; Vinti H; Rosenthal E; Pesce A; Cassuto JP
High versus ultra-high purity factor VIII concentrate therapy: prospective evaluation of immunological and clinical parameters in HIV seronegative and seropositive hemophiliacs.: Thromb Haemost. 1994 Sep;72(3):359-62. Unique Identifier : AIDSLINE MED/95159067; Varon D; Schulman S; Dardik R; Barzilai A; Bashari D; Martinowitz U; National Hemophilia Centre, Chaim Sheba Medical Centre,; Tel-Hashomer, Israel.; This study aimed at evaluation of the immunological status and the clinical course of both HIV seronegative and seropositive hemophiliacs treated with either an ultra-pure factor VIII product (UP-F VIII), or a high-purity F VIII (HP-F VIII) concentrate. Eighteen HIV seronegative patients were divided into two groups o
New developments and old problems [editorial]: Trop Geogr Med. 1994;46(5):269. Unique Identifier : AIDSLINE MED/95159212; de Geus A
Tuberculosis in Africa--any news?: Trop Geogr Med. 1994;46(5):271-4. Unique Identifier : AIDSLINE MED/95159213; van der Werf TS; Department of Pulmonary Diseases, University Hospital Groningen,; The Netherlands.; The tuberculosis situation in Africa in the AIDS era has become bleak. The tuberculosis incidence has increased in most sub-Saharan African countries, diagnosis has become more difficult, response to treatment, though initially good, is eventually less effective, and patient compliance, which has been a major problem
Development of a serological test for tuberculosis. Problems and potential.: Trop Geogr Med. 1994;46(5):275-9. Unique Identifier : AIDSLINE MED/95159214; Verbon A; Division of Internal Medicine, Academic Medical Centre,; Amsterdam, The Netherlands.; The secreted antigens of 24K and 38K and the hsp of 12K and 16K are valuable as reagents in a serodiagnostic assay for tuberculosis. A combination of the TB72 assay with either the 16K or 24K antigen gives the best sensitivity and specificity. Antigens isolated from mycobacterial cultures are valuable in a serological
Chest radiography and beta-2-microglobulin levels in HIV-seronegative and HIV-seropositive African patients with pulmonary tuberculosis.: Trop Geogr Med. 1994;46(5):283-7. Unique Identifier : AIDSLINE MED/95159216; Richter C; Pallangyo KJ; Ndosi BN; Chum HJ; Swai AB; Shao J; Department of Medicine, Ministry of Health, Dar es Salaam,; Tanzania.; To examine the relationship between radiographic features, serum beta-2-microglobulin (beta-2-M) levels, results of sputum-smear microscopy and outcome, we performed a retrospective study of 99 HIV-seropositive and 162 HIV-seronegative patients with pulmonary tuberculosis (TB) in Dar es Salaam,
Diagnosis of tuberculous lymphadenitis in an area of HIV infection and limited diagnostic facilities.: Trop Geogr Med. 1994;46(5):288-92. Unique Identifier : AIDSLINE MED/95159217; Perenboom RM; Richter C; Swai AB; Kitinya J; Mtoni I; Chande H; Kazema RR; Mwakyusa DH; Maselle SY; Department of Medicine, Muhimbili Medical Centre, Dar es Salaam,; Tanzania.; In order to evaluate procedures leading to the diagnosis of tuberculous lymphadenitis, a prospective clinical study was carried out of patients with lymphadenopathy admitted to the medical wards of a referral hospital in Tanzania . The yield of diagnostic procedures (direct aurami
Diagnosis of tuberculosis in patients with pleural effusion in an area of HIV infection and limited diagnostic facilities.: Trop Geogr Med. 1994;46(5):293-7. Unique Identifier : AIDSLINE MED/95159218; Richter C; Perenboom R; Swai AB; Kitinya J; Mtoni I; Chande H; Kazema RR; Chuwa LM; Mwakyusa DH; Maselle SY; Department of Medicine, Muhimbili Medical Centre, Dar es Salaam,; Tanzania.; In a prospective study of 118 patients with pleural effusion, tuberculosis (TB) was diagnosed in 112. In 84 patients the diagnosis of TB was made by detection of acid-fast bacilli by stain (auramine, Ziehl-Neelsen) or by culture of mycobacteria (Lowenstein-Jensen medium) in pleural fluid or pleural tissue (obtained by
Serological tests for Lyme disease in patients with tropical spastic paraparesis and healthy Jamaicans.: Trop Geogr Med. 1994;46(5):329-30. Unique Identifier : AIDSLINE MED/95159228; Smikle MF; Morgan OS; Barton EN; Bailey V; Blattner WA; Department of Microbiology, University of the West Indies, Mona,; Kingston, Jamaica.; The significance of reactive serological tests for Lyme disease in patients with tropical spastic paraparesis (TSP) was assessed by examining serum samples from 128 of these patients and 200 healthy Jamaicans by Lyme indirect immunofluorescent antibody (IFA), enzyme immuno-assay (EIA) and Western blot analyses. Sera w
Adenovirus infection of the duodenum in an AIDS patient: an ultrastructural study.: Ultrastruct Pathol. 1994 Nov-Dec;18(6):549-51. Unique Identifier : AIDSLINE MED/95159244; Yi ES; Powell HC; Department of Pathology, School of Medicine, University of; California at San Diego 92103-8720.; Intractable diarrhea in a 40-year-old woman with terminal acquired immunodeficiency syndrome resulted from adenovirus infection of the duodenal mucosa. Electron microscopic examination of a duodenal biopsy specimen performed because of clinical suspicion of cryptosporidiosis or
Neonatal circumcision.: Urol Clin North Am. 1995 Feb;22(1):57-65. Unique Identifier : AIDSLINE MED/95159278; Niku SD; Stock JA; Kaplan GW; Division of Urology, University of California, San Diego Medical; Center.; Circumcision remains the most common operation performed in males in the United States . When performed by an experienced operator, circumcision is usually a safe and simple operation. The medical benefits of circumcision appear to exceed the risks of the procedure. The history, embryol
Porcine T-cell receptors: molecular and biochemical characterization.: Vet Immunol Immunopathol. 1994 Oct;43(1-3):13-8. Unique Identifier : AIDSLINE GENBANK/L21163; Thome M; Hirt W; Pfaff E; Reddehase MJ; Saalmuller A; Federal Research Centre for Virus Diseases of Animals, Tubingen,; Germany.; Two subclasses of CD3 associated T-cell receptors (TcR) have been described so far, consisting of either an alpha and beta chain (TcR alpha beta) or a gamma and delta chain (TcR gamma delta). Of the two subclasses, the TcR alpha beta is the one predominantly expressed on peripheral T lymphocytes of humans and rodents.
Characteristics of porcine T lymphocytes and T-cell lines.: Vet Immunol Immunopathol. 1994 Oct;43(1-3):45-52. Unique Identifier : AIDSLINE MED/95159399; Saalmuller A; Bryant J; Federal Research Centre for Virus Diseases of Animals, Tubingen,; Germany.; Monoclonal antibodies (mAb) against leucocyte differentiation antigens have altered the way in which immunologists examine the immune system. These mAb allow us to identify distinct surface molecules on leucocyte populations, by which these cells can be classified, isolated and studied for their functional properties.
Porcine peripheral blood CD4+/CD8+ dual expressing T-cells.: Vet Immunol Immunopathol. 1994 Oct;43(1-3):53-62. Unique Identifier : AIDSLINE MED/95159401; Pescovitz MD; Sakopoulos AG; Gaddy JA; Husmann RJ; Zuckermann FA; Department of Surgery, Indiana University, Indianapolis 46202.; The porcine T-cell population is unique in that there is a large percentage of CD+CD8+ dual expressing peripheral T-cells. This paper reviews the data available on these porcine T-cells and compares them to the much rarer dual expressing T-cells in humans. The percent of dual expressing cells increases with activation
An experimental study of primary feline immunodeficiency virus infection in cats and a historical comparison to acute simian and human immunodeficiency virus diseases.: Vet Immunol Immunopathol. 1994 Nov;43(4):337-55. Unique Identifier : AIDSLINE MED/95159407; Dua N; Reubel G; Moore PF; Higgins J; Pedersen NC; Department of Medicine and Epidemiology, School of Veterinary; Medicine University of California, Davis 95616.; Sixteen adolescent specific pathogen free cats were inoculated with the Petaluma strain of feline immunodeficiency virus (FIV) and two cats were then necropsied at each of 5, 10, 21, 28, 42, 56, 70, and 84 day time points following infection. Lymphadenopathy gradually increased starting at Day 10 and persisted for the
HTLV-1 Tax enhances NF-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100.: Virology. 1995 Feb 1;206(2):1066-74. Unique Identifier : AIDSLINE MED/95159418; Murakami T; Hirai H; Suzuki T; Fujisawa J; Yoshida M; Department of Cellular and Molecular Biology, University of; Tokyo, Japan.; Tax protein of HTLV-1 triggers transcriptional activation through enhancers, NF-kappa B binding site, 21-bp enhancer, and serum response element. Previously, we demonstrated binding of Tax to transcription factors NF-kappa B1 p105 and p50. Here, we report that Tax enhances expression of NF-kappa B2 at the mRNA level a
HIV-1 envelope glycoprotein gp120 does not bind to galactosylceramide-expressing rat oligodendrocytes.: Virology. 1995 Feb 1;206(2):1084-91. Unique Identifier : AIDSLINE MED/95159420; Parmantier E; Monge M; Yagello M; Cabon F; Demerens C; Gluckman JC; Zalc B; Laboratoire de Neurobiologie Cellulaire, Moleculaire et; Clinique, INSERM U, 134, Paris, France.; It may be postulated that the encephalopathy induced by the human immunodeficiency virus HIV-1, in particular, the characteristic myelin pallor, may result from binding of the envelope glycoprotein gp120 to galactosylceramide and/or its metabolite sulfatide in the plasma membrane of oligodendrocytes, the myelin formin
Functional similarities between HIV-1 Tat and DNA sequence-specific transcriptional activators.: Virology. 1995 Feb 1;206(2):1150-4. Unique Identifier : AIDSLINE MED/95159430; Madore SJ; Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.; The Tat regulatory protein encoded by human immunodeficiency virus type 1 (HIV-1) induces high levels of transcription from the viral long terminal repeat (LTR) promoter element after interacting with a promoter proximal RNA target sequence. In the wild-type HIV-1 LTR, this activation is facilitated by the synergistic
Differences in feline immunodeficiency virus host cell range correlate with envelope fusogenic properties.: Virology. 1995 Feb 1;206(2):796-806. Unique Identifier : AIDSLINE MED/95159433; Pancino G; Castelot S; Sonigo P; Genetique des Virus (ICGM-CNRS UPR 0415) Institut Cochin de; Genetique Moleculaire, Paris, France.; Feline immunodeficiency virus (FIV) establishes persistent infections in cats inducing an acquired immunodeficiency syndrome. Differences in cell tropism have been observed among isolates of FIV (T. R. Phillips et al., J. Virol. 64, 4605-4613, 1990). The progeny of the infectious molecular clone of FIV p34TF10 was abl
Minimal sequence requirements for synthetic peptides derived from the V3 loop of the human immunodeficiency virus type 1 (HIV-1) to enhance HIV-1 binding to cells and infection.: Virology. 1995 Feb 1;206(2):807-16. Unique Identifier : AIDSLINE MED/95159434; Zanotto C; Calderazzo F; Dettin M; Di Bello C; Autiero M; Guardiola J; Chieco-Bianchi L; De Rossi A; Institute of Oncology, Interuniversity Center for Cancer; Research, Padova, Italy.; We previously demonstrated that a 23-mer peptide (DB3) derived from the V3 loop of the surface glycoprotein of HIV-1 MN strain was able to bind to soluble CD4 and enhance HIV-1 infection. The mechanism and structural features required for these biological activities were studied by using shortened DB3 derivatives and
Overexpression of human immunodeficiency virus type 1 protease increases intracellular cleavage of Gag and reduces virus infectivity.: Virology. 1995 Feb 1;206(2):854-65. Unique Identifier : AIDSLINE MED/95159439; Luukkonen BG; Fenyo EM; Schwartz S; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.; Here we have investigated if human immunodeficiency virus type 1 (HIV-1) protease expressed in trans can interfere with production of infectious HIV-1 particles. Protease produced from a Tat and Rev inducible expression plasmid specifically cleaved HIV-1 p55Gag in a dose-dependent manner. Coexpression of protease and
Small amino acid sequence changes within the V2 domain can affect the function of a T-cell line-tropic human immunodeficiency virus type 1 envelope gp120.: Virology. 1995 Feb 1;206(2):878-84. Unique Identifier : AIDSLINE MED/95159441; Koito A; Stamatatos L; Cheng-Mayer C; Department of Medicine, University of California, San Francisco; 94143-0128.; Prior studies with recombinant viruses constructed in vitro showed that the V2 domain of envelope gp120, in addition to the required V3 domain, enhances the efficiency of infection of primary macrophages by HIV-1. Present structural studies on the gp120s of these recombinant viruses using three human monoclonal antibo
Mutations of conserved cysteine residues in the CWLC motif of the oncoretrovirus SU protein affect maturation and translocation.: Virology. 1995 Feb 1;206(2):885-93. Unique Identifier : AIDSLINE MED/95159442; Gu J; Parthasarathi S; Varela-Echavarria A; Ron Y; Dougherty JP; Department of Molecular Genetics and Microbiology, Robert Wood; Johnson Medical School, University of Medicine and Dentistry of; New Jersey, Piscataway 08854-5635.; The envelope glycoprotein complex is composed of two polypeptides, an external heavily glycosylated polypeptide (SU) and a membrane-spanning protein (TM). Together they form a heterodimer on the surface of the virion. These proteins are synthesized in the form of a polyprotein precursor which is glycosylated and prote
Activation of the interferon-inducible enzymes, 2',5'-oligoadenylate synthetase and PKR by human T-cell leukemia virus type I Rex-response element.: Virology. 1995 Feb 1;206(2):913-22. Unique Identifier : AIDSLINE MED/95159445; Mordechai E; Kon N; Henderson EE; Suhadolnik RJ; Department of Biochemistry, Temple University School of Medicine,; Philadelphia, Pennsylvania 19140.; In vitro-synthesized human T-cell leukemia virus type 1 (HTLV-I) Rex response element (Rex-RE) activates the interferon-induced 2 ,5 -oligoadenylate synthetase (2-50AS) in a dose-dependent manner. In addition, Rex-RE at 1 microgram/ml activates a second interferon-induced enzyme, p68 kinase (PKR); however, at 50 micro
[Development of new virus vectors for gene therapy]: Uirusu. 1994 Jun;44(1):95-9. Unique Identifier : AIDSLINE MED/95159471; Shimada T
Influenza A subtype cross-protection after immunization of outbred mice with a purified chimeric NS1/HA2 influenza virus protein.: Vaccine. 1994 Nov;12(14):1340-8. Unique Identifier : AIDSLINE MED/95159654; Mbawuike IN; Dillion SB; Demuth SG; Jones CS; Cate TR; Couch RB; Department of Microbiology and Immunology, Baylor College of; Medicine, Houston, TX 77030-3498.; Influenza A/PR/8/34-derived chimeric (D) protein (SK&F 106160) composed of the first 81 amino acids (aa) of NS1 fused to the conserved 157 C-terminal aa of HA2 (NS1 1-81-HA2 65-222) was previously shown to induce H-2d-restricted protective cytotoxic T-lymphocyte (CTL) immunity in inbred mice. However, D protein, li
Elements in the long terminal repeat of HIV-1 that interact with nuclear extracts from Jurkat cells persistently infected with vaccinia virus.: Virus Res. 1994 Nov;34(2):127-38. Unique Identifier : AIDSLINE MED/95159659; Chang PY; Stellrecht K; Melana S; Pogo BG; Department of Microbiology, Mount Sinai School of Medicine, New; York, NY 10029.; Previous reports showed transactivation of the long terminal repeat (LTR) of HIV-1 in Jurkat cells persistently infected with vaccinia virus. In this communication, electrophoretic mobility shift assays were used to characterize the elements in HIV-1 LTR which might be responsible for the mechanism of transactivation.
[Immune system indices for the prediction of the course of human immunodeficiency virus infection]: Zh Mikrobiol Epidemiol Immunobiol. 1994 Aug-Sep;Suppl 1:114-8. Unique Identifier : AIDSLINE MED/95159695; Gabrilovich DI; Serebrovskaia LV; Khabarova VV; Kravchenko AV; Avdeeva LA; Shalygina NB; Pokrovskii VV; In 25 persons having HIV infection with different dynamics of the progress of the disease the content of lymphocyte populations was studied (by the methods of rosette formation and with the use of monoclonal antibodies) and the rosette-forming and functional metabolic activity of neutrophils was determined. In compari
Hypothalamic-pituitary-adrenal axis and immune system.: Acta Neurol (Napoli). 1994 Aug;16(4):206-13. Unique Identifier : AIDSLINE MED/95159844; Savastano S; Tommaselli AP; Valentino R; Scarpitta MT; D'Amore G; Luciano A; Covelli V; Lombardi G; Chair of Endocrinology, C.E.O.S. National Research Council (CNR),; Italy.; Complex and bidirectional relationships operate between the hypothalamic-pituitary-adrenal (HPA) axis and the immune system (IS) and either in vivo or in vitro evidence supports a physiological role of the HPA axis-IS network. A part of the well-known pharmacological effects of glucocorticoid hormones (GC) as immunode
[Urologic manifestations in patients with acquired immunodeficiency syndrome]: Actas Urol Esp. 1994 Nov-Dec;18(10):949-52. Unique Identifier : AIDSLINE MED/95159852; Martinez Jabaloyas JM; Ruiz Cerda JL; Rodrigo Aliaga M; Osca Garcia JM; Morera Martinez J; Lacruz J; Jimenez Cruz JF; Servicio de Urologia, Hospital Universitario La Fe, Valencia.; In order to know the incidence and nature of urological conditions in the Acquired Immunodeficiency Syndrome, a revision was made of 223 clinical histories from patients admitted to our hospital between 1998 and 1992. Some 24.6% developed urological conditions with prevalence of unspecific urinary infections, though s
FDA 'remains committed' to quick approval of AIDS drugs [news]: Am Pharm. 1994 Dec;NS34(12):14. Unique Identifier : AIDSLINE MED/95159871
Federal task force advises on zidovudine use during pregnancy [news]: Am J Hosp Pharm. 1994 Dec 15;51(24):3020-1. Unique Identifier : AIDSLINE MED/95159993
Zidovudine-associated myopathy.: Am J Hosp Pharm. 1994 Dec 15;51(24):3026-8. Unique Identifier : AIDSLINE MED/95159995; Paradis J; Calis KA; Woodhaven Institutional Pharmacies, Baltimore, MD 21201.
Ex vivo human placental transfer of human immunodeficiency virus-1 p24 antigen.: Am J Obstet Gynecol. 1995 Feb;172(2 Pt 1):530-2. Unique Identifier : AIDSLINE MED/95160057; Bawdon RE; Gravell M; Roberts S; Hamilton R; Dax J; Sever J; Department of Obstetrics and Gynecology, University of Texas; Southwestern Medical Center, Dallas.; OBJECTIVE: Our purpose was to determine whether human immunodeficiency virus-1 p24 antigen crosses the human placenta and, if so, to determine its clearance index relative to antipyrine. STUDY DESIGN: Eight term human placentas from uncomplicated vaginal or cesarean section deliveries were studied by ex vivo placental
Genital ulcer disease in women infected with human immunodeficiency virus.: Am J Obstet Gynecol. 1995 Feb;172(2 Pt 1):553-62. Unique Identifier : AIDSLINE MED/95160061; LaGuardia KD; White MH; Saigo PE; Hoda S; McGuinness K; Ledger WJ; Department of Obstetrics and Gynecology, New York; Hospital-Cornell Medical Center, NY 10021.; OBJECTIVE: The purpose of this study was to determine the prevalence and microbiologic characteristics of genital ulcer disease in a population of human immunodeficiency virus-infected women. STUDY DESIGN: A retrospective cohort study was performed in university-affiliated, hospital-based women s human immunodeficienc
Risk factors for mother-to-child transmission of human immunodeficiency virus-1 infection.: Am J Obstet Gynecol. 1995 Feb;172(2 Pt 1):700-5. Unique Identifier : AIDSLINE MED/95160086; Temmerman M; Nyong'o AO; Bwayo J; Fransen K; Coppens M; Piot P; Department of Medical Microbiology, University of Nairobi, Kenya.; OBJECTIVE: Our aim was to examine maternal, obstetric, and infant characteristics of mother-to-child transmission of human immunodeficiency virus-1 in Nairobi, Kenya . STUDY DESIGN: Proviral human immunodeficiency virus-1 was detected by polymerase chain reaction in peripheral blood
Sequence and phylogenetic analyses of human T cell lymphotropic virus type 1 from a Brazilian woman with adult T cell leukemia: comparison with virus strains from South America and the Caribbean basin.: Am J Trop Med Hyg. 1995 Jan;52(1):101-8. Unique Identifier : AIDSLINE MED/95160207; Song KJ; Nerurkar VR; Pereira-Cortez AJ; Yamamoto M; Taguchi H; Miyoshi I; Yanagihara R; Laboratory of Central Nervous System Studies, National Institute; of Neurological Disorders and Stroke, National Institutes of; Health, Bethesda, Maryland.; Human T cell lymphotropic virus type 1 (HTLV-1) is endemic in South America and the Caribbean basin. To clarify the genetic and phylogenetic relationship between an HTLV-1 strain isolated from a Brazilian woman with adult T cell leukemia and viral isolates from elsewhere in South America and from other geographic regi
Use of cross-reactive antigens of the microsporidian Glugea atherinae for the possible detection of Enterocytozoon bieneusi by western blot.: Am J Trop Med Hyg. 1995 Jan;52(1):89-93. Unique Identifier : AIDSLINE MED/95160223; Ombrouck C; Romestand B; da Costa JM; Desportes-Livage I; Datry A; Coste F; Bouix G; Gentilini M; Unite INSERM 313, CHU Pitie-Salpetriere, Paris, France.; The microsporidia Enterocytozoon bieneusi is reported in 10-30% of those infected with the human immunodeficiency virus. The parasite appears to be a cause of gastralgia, malabsorption, and diarrhea. A Western blot technique using another microsporidian species, Glugea atherinae, has demonstrated an antigenic similari
Early detection of antibodies to human immunodeficiency virus 1 by a third-generation enzyme immunoassay. A comparative study with the results of second-generation immunoassays and western blot.: Ann Biol Clin (Paris). 1994;52(5):341-5. Unique Identifier : AIDSLINE MED/95160327; Barbe F; Klein M; Badonnel Y; Laboratoire de chimie biologique, maternite regionale de Nancy,; France.; The aim of the study was to examine the sensitivity and the specificity of a HIV-1/HIV-2 third-generation enzyme immunoassay, the Abbott recombinant HIV-1/HIV-2 third-generation enzyme immunoassay, which is reported to detect simultaneously IgG and IgM. Sensitivity was evaluated with sera from seropositive subjects an
Newsletter tracks needlestick injuries.: Am Nurse. 1995 Jan-Feb;27(1):10. Unique Identifier : AIDSLINE MED/95160351
Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy. AIDS Clinical Trials Group Protocol 116B/117 Team and the Virology Committee Resistance Working Group.: Ann Intern Med. 1995 Mar 15;122(6):401-8. Unique Identifier : AIDSLINE MED/95160383; D'Aquila RT; Johnson VA; Welles SL; Japour AJ; Kuritzkes DR; DeGruttola V; Reichelderfer PS; Coombs RW; Crumpacker CS; Kahn JO; et al; Massachusetts General Hospital, Beth Israel Hospital, Harvard; Medical School, Boston.; OBJECTIVE: To evaluate the association between resistance of human immunodeficiency virus type 1 (HIV-1) to zidovudine and clinical progression. DESIGN: Retrospective analysis of specimens from patients in the AIDS Clinical Trials Group (ACTG) protocol 116B/117, a randomized comparison of didanosine with continued zid
Alpha-lipoic acid increases intracellular glutathione in a human T-lymphocyte Jurkat cell line.: Biochem Biophys Res Commun. 1995 Feb 6;207(1):258-64. Unique Identifier : AIDSLINE MED/95160683; Han D; Tritschler HJ; Packer L; Department of Molecular and Cell Biology, University of; California at Berkeley 94720-3200.; The addition of exogenous alpha-lipoic acid to cellular medium causes a rapid increase of intracellular unbound thiols in Jurkat cells, a human T-lymphocyte cell line. The rise of cellular thiols is a result of the cellular uptake and reduction of lipoic acid to dihydrolipoic acid and a rise in intracellular glutathio
[Association of Castleman's disease and Hodgkin's disease. Eight cases and review of the literature]: Ann Pathol. 1994;14(6):384-91. Unique Identifier : AIDSLINE MED/95160809; Molinie V; Perie G; Melo I; Melo C; Audouin J; Diebold J; Service central Jacques Delarue d'Anatomie et Cytologie; Pathologiques, Paris.; We have recorded 8 patients presenting a Hodgkin s disease associated with Castleman s disease. Four men and 4 women with a 44 years mean age (15-60), presented as a solitary mass (2/7) or as a multicentric tumoral disease (5/7). One of our patients was HIV. Histological studies showed typical features of Castleman s
[Pulmonary involvement in the course of infection by human immunodeficiency virus (letter; comment)]: Ann Pathol. 1994;14(6):425. Unique Identifier : AIDSLINE MED/95160819; Pulik M; Lionnet F; Couderc LJ; Genet P; Petitdidier C
Identifying newborn babies who test positive for the human immunodeficiency virus [news]: Birth. 1994 Jun;21(2):115-6. Unique Identifier : AIDSLINE MED/95160841
Transmission of the human immunodeficiency virus (HIV) by artificial insemination [news]: Birth. 1994 Sep;21(3):177. Unique Identifier : AIDSLINE MED/95160857
The controversy over AIDS testing of newborns [news]: Birth. 1994 Dec;21(4):233-4. Unique Identifier : AIDSLINE MED/95160868
Genitourinary tuberculosis: the importance of early diagnosis and management. Case presentation.: Bol Asoc Med P R. 1994 Oct-Dec;86(10-12):75-80. Unique Identifier : AIDSLINE MED/95160885; Bernaschina CP; Cabrera M; Cardona P; Colon B; Department of Surgery, University of Puerto Rico, School of; Medicine.; Genitourinary tuberculosis is the second most common form of extrathoracic tuberculosis. The most common signs are persistent sterile pyuria in up to 90% of patients, irritative voiding symptoms and painless hematuria in up to 80% of the patients. In Puerto Rico the incidence o
The emerging epidemic of HIV infection and AIDS in Asia and the Pacific.: AIDS. 1994;8 Suppl 2:S1-2. Unique Identifier : AIDSLINE MED/95160964; Kaldor JM; Sittitrai W; John TJ; Kitamura T; National Centre in HIV Epidemiology and Clinical Research,; University of New South Wales, Sydney, Australia.
HIV/AIDS in Myanmar.: AIDS. 1994;8 Suppl 2:S105-9. Unique Identifier : AIDSLINE MED/95160965; Htoon MT; Lwin HH; San KO; Zan E; Thwe M; AIDS Prevention and Control Programme, Department of Health,; Ministry of Health, Myanmar.
AIDS in the Pacific Islands.: AIDS. 1994;8 Suppl 2:S111-6. Unique Identifier : AIDSLINE MED/95160966; Osuga K; Chang C; Global Programme on AIDS, World Health Organization, Suva, Fiji.
HIV/AIDS prevention and control in Papua New Guinea.: AIDS. 1994;8 Suppl 2:S117-24. Unique Identifier : AIDSLINE MED/95160967; Malau C; O'Leary M; Jenkins C; Faraclas N; National Department of Health, Boroko, Papua, New Guinea.
HIV/AIDS in the Philippines.: AIDS. 1994;8 Suppl 2:S125-30. Unique Identifier : AIDSLINE MED/95160968; Tan ML; Dayrit MM; Health Action Information Network, Quezon City, Philippines.
The molecular epidemiology of HIV in Asia.: AIDS. 1994;8 Suppl 2:S13-28. Unique Identifier : AIDSLINE +; Weniger BG; Takebe Y; Ou CY; Yamazaki S; Centers for Disease Control and Prevention, Atlanta, Georgia.
The recent epidemiology of HIV and AIDS in Thailand.: AIDS. 1994;8 Suppl 2:S131-41. Unique Identifier : AIDSLINE MED/95160970; Brown T; Sittitrai W; Vanichseni S; Thisyakorn U; Program on Population, East-West Center, Honolulu, Hawaii 96848.
Risk factors for HIV infection in Thailand.: AIDS. 1994;8 Suppl 2:S143-53. Unique Identifier : AIDSLINE MED/95160971; Sittitrai W; Brown T; Program on AIDS, Thai Red Cross Society, Bangkok, Thailand.
The Thai response to the HIV/AIDS epidemic.: AIDS. 1994;8 Suppl 2:S155-63. Unique Identifier : AIDSLINE MED/95160972; Ungphakorn J; Sittitrai W; ACCESS, Bangkok, Thailand.
HIV and AIDS in Asia and the Pacific: an epidemiological overview.: AIDS. 1994;8 Suppl 2:S165-72. Unique Identifier : AIDSLINE MED/95160973; Kaldor JM; Effler P; Sarda R; Petersen G; Gertig DM; Narain JP; National Centre in HIV Epidemiology and Clinical Research,; University of New South Wales, Sydney, Australia.
Risk factors for HIV transmission in Asia and the Pacific.: AIDS. 1994;8 Suppl 2:S173-82. Unique Identifier : AIDSLINE MED/95160974; Brown T; Mulhall B; Sittitrai W; Program on Population, East-West Center, Honolulu, Hawaii 96848.
Governments of Asia and the Pacific responding to the HIV/AIDS pandemic.: AIDS. 1994;8 Suppl 2:S183-98. Unique Identifier : AIDSLINE MED/95160975; Tarantola D; Mann J; Viravaidya M; Moodie R; Sundararaman S; Francois-Xavier Bagnoud Center for Health and Human Rights,; Harvard School of Public Health, Cambridge, Massachusetts 02138.
Non-governmental organization and community responses to HIV/AIDS in Asia and the Pacific.: AIDS. 1994;8 Suppl 2:S199-206. Unique Identifier : AIDSLINE MED/95160976; Sittitrai W; Program on AIDS, Thai Red Cross Society, Bangkok, Thailand.
Social policy, human rights, and HIV/AIDS in Asia and the Pacific.: AIDS. 1994;8 Suppl 2:S207-13. Unique Identifier : AIDSLINE MED/95160977; Tan ML; Brown T; Health Action Information Network, Quezon City, Philippines.
Early HIV infection.: AIDS. 1994;8 Suppl 2:S29-34. Unique Identifier : AIDSLINE MED/95160978; Hoy JF; Wright EJ; Kimura S; Clinical Research Department, Fairfield Hospital, Melbourne,; Victoria, Australia.
AIDS pathogenesis.: AIDS. 1994;8 Suppl 2:S3-11. Unique Identifier : AIDSLINE MED/95160979; Lewin SR; Crowe SM; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria, Australia.
Late manifestations of HIV in Asia and the Pacific.: AIDS. 1994;8 Suppl 2:S35-43. Unique Identifier : AIDSLINE MED/95160980; Clezy K; Sirisanthana T; Sirisanthana V; Brew B; Cooper DA; National Centre in HIV Epidemiology and Clinical Research,; Sydney, NSW, Australia.
Involving the communities: AIDS in Australia and New Zealand.: AIDS. 1994;8 Suppl 2:S45-53. Unique Identifier : AIDSLINE MED/95160981; Crofts N; Ballard J; Chetwynd J; Dickson N; Lindberg W; Watson C; Macfarlane Burnet Centre for Medical Research, Fairfield,; Victoria.
AIDS and HIV infection in China.: AIDS. 1994;8 Suppl 2:S55-9. Unique Identifier : AIDSLINE MED/95160982; Sun X; Nan J; Guo Q; Department of Epidemic Prevention, Ministry of Public Health,; People's Republic of China.
Epidemiology of HIV and AIDS in India.: AIDS. 1994;8 Suppl 2:S61-75. Unique Identifier : AIDSLINE MED/95160983; Jain MK; John TJ; Keusch GT; Department of Virology and Microbiology, Christian Medical; College, Vellore, India.
Risk factors for HIV transmission in India.: AIDS. 1994;8 Suppl 2:S77-82. Unique Identifier : AIDSLINE MED/95160984; Narain JP; Jha A; Lal S; Salunke S; World Health Organization South-East Asia Regional Office, New; Delhi.
Government response to HIV/AIDS in India.: AIDS. 1994;8 Suppl 2:S83-90. Unique Identifier : AIDSLINE MED/95160985; Dasgupta PR; Jain MK; John TJ; Ministry of Health and Family Welfare, Government of India, New; Delhi.
HIV and AIDS in Indonesia.: AIDS. 1994;8 Suppl 2:S91-4. Unique Identifier : AIDSLINE MED/95160986; Jalal F; Abednego HM; Sadjimin T; Linnan MJ; Bureau for Social Welfare, Health and Nutrition, National; Development Planning Agency, BAPPENAS, Jakarta, Indonesia.
Summary of the epidemiology of HIV/AIDS in Japan.: AIDS. 1994;8 Suppl 2:S95-7. Unique Identifier : AIDSLINE MED/95160987; Kitamura T; National Institute of Health, Tokyo, Japan.
AIDS in Malaysia.: AIDS. 1994;8 Suppl 2:S99-103. Unique Identifier : AIDSLINE MED/95160988; Singh J; Che'Rus S; Chong S; Chong YK; Crofts N; International Medical College, Selangor Darul Ehsan, Petaling; Jaya, Malaysia.
Tonsillectomy and the immune system: a long-term follow up comparison between tonsillectomized and non-tonsillectomized children.: Eur Arch Otorhinolaryngol. 1994;251(7):423-7. Unique Identifier : AIDSLINE MED/95161050; Bock A; Popp W; Herkner KR; Department of Pediatrics, University Hospital, Vienna, Austria.; Immunological functions of the tonsils and possible effects of their removal are still controversial. One reason for this is the lack of long-term follow-up investigations after tonsillectomy. In the present study selected parameters of the cellular and humoral immune systems of 160 children 0.5-11 years after tonsill
Synthesis and enantiomeric purity determination of chiral 3-benzylglycidol, a key synthon for HIV protease inhibitors.: Chirality. 1994;6(8):681-4. Unique Identifier : AIDSLINE MED/95161218; Shum WP; Chen J; Cannarsa MJ; Research and Development Department, ARCO Chemical Company,; Newtown Square, Pennsylvania 19073-2387.; The detailed synthesis of (2R,3R)-3-benzylglycidol by the Sharpless asymmetric epoxidation route is described. The enantiomeric purity determination of this compound is complicated by the presence of small quantities of the diastereometric (2R,3S)-3-benzylglycidol from the asymmetric epoxidation of the cis-allylic alc
Predictors of HIV testing among runaway and homeless adolescents.: J Adolesc Health. 1994 Nov;15(7):566-72. Unique Identifier : AIDSLINE MED/95161420; Goodman E; Berecochea JE; Division of Adolescent Medicine, Children's Hospital, Boston, MA.; PURPOSE: Although runaway and homeless adolescents are at high risk for acquiring HIV infection, little is known about which of these youth obtain HIV testing or whether those considered to be at highest risk are being tested. The purpose of our study was to determine demographic characteristics and risk profiles of r
Evaluating a school-based intervention for STD/AIDS prevention in Peru.: J Adolesc Health. 1994 Nov;15(7):582-91. Unique Identifier : AIDSLINE MED/95161423; Caceres CF; Rosasco AM; Mandel JS; Hearst N; Institute for Population Studies, Universidad Cayetano Heredia,; Lima, Peru.; PURPOSE: In a context of increasing HIV/STD risks among adolescents in Latin America, new conceptions of sequential sex education are needed. However, older adolescents must be reached through shorter programs. A quasi-experimental study was conducted to evaluate the impact of a short school-based STD/AIDS prevention
Too afraid to care.: Nurs BC. 1994 Nov-Dec;26(5):38. Unique Identifier : AIDSLINE MED/95161531; Charlie L
Candida and oral candidosis: a review.: Crit Rev Oral Biol Med. 1994;5(2):125-57. Unique Identifier : AIDSLINE MED/95161555; Scully C; el-Kabir M; Samaranayake LP; Eastman Dental Institute for Oral Healthcare Sciences, London,; England.; Candida species are the most common fungal pathogens isolated from the oral cavity. Their oral existence both as a commensal and an opportunist pathogen has intrigued clinicians and scientists for many decades, and recent investigations have revealed many attributes of this fungus contributing to its pathogenicity. In
HIV-related tumors of the oral cavity.: Crit Rev Oral Biol Med. 1994;5(2):159-85. Unique Identifier : AIDSLINE MED/95161556; Ficarra G; Eversole LE; Institute of Odontology and Stomatology, University of Florence,; Italy.; In HIV-infected patients with AIDS the most frequent malignancies are Kaposi s sarcoma and non-Hodgkin s lymphoma . In these patients, the natural history of these tumors is quite different from those of HIV-negative subjects. These tumors may present atypical clinical aspects, may
[Deep venous thrombosis of the upper limb in IVDA patients with HIV infection: a report of 3 cases (letter)]: An Med Interna. 1994 Sep;11(9):467-8. Unique Identifier : AIDSLINE MED/95161573; Valencia ME; Adrados M; Moreno V; Gozalez Lahoz J
Exacerbation of collagen-induced arthritis in rats by rat cytomegalovirus is antigen-specific.: Autoimmunity. 1994;18(3):177-87. Unique Identifier : AIDSLINE MED/95161578; Griffiths MM; Sawitzke AD; Harper DS; McCall S; Reese VR; Cannon GW; Research Service, Salt Lake City Veteran Affairs Medical Center,; UT.; Collagen-Induced Arthritis (CIA) is an experimentally induced and genetically controlled animal model of chronic joint inflammation. In rats, there are informative strain differences in susceptibility to CIA. DA rats (RT1avl) develop severe CIA after immunization with bovine (BII), chick (CII), or homologous rat (RII)
Anti-nuclear, anti-neutrophil cytoplasmic and anti-glomerular basement membrane antibodies in HIV-infected individuals.: Autoimmunity. 1994;18(3):205-11. Unique Identifier : AIDSLINE MED/95161581; Savige JA; Chang L; Horn S; Crowe SM; University Department of Medicine, Austin Hospital, Heidelberg,; Victoria, Australia.; Many autoantibodies have been described in HIV-infected individuals. We have examined the incidence, associations and prognostic significance of anti-nuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA) and anti-glomerular basement membrane (GBM) antibodies in individuals with HIV infections. One hu
Human Th1 and Th2 cells: functional properties, regulation of development and role in autoimmunity.: Autoimmunity. 1994;18(4):301-8. Unique Identifier : AIDSLINE MED/95161592; De Carli M; D'Elios MM; Zancuoghi G; Romagnani S; Del Prete G; University of Florence, Italy.; Evidence has accumulated suggesting the existence in humans of polarized T helper (Th) cell subsets, coded as Th1 and Th2, with defined cytokine secretion profiles. Immune responses to intracellular bacteria and viruses result in the preferential development of the Th1 cell subset. Th1 cells express cytolytic activity
Anti-HIV effect of immunomodulating agent, levamisole, in vitro.: Biomed Pharmacother. 1994;48(7):327-30. Unique Identifier : AIDSLINE MED/95161644; Bourinbaiar AS; Lee-Huang S; Krasinski K; Borkowsky W; Department of Biochemistry, New York University Medical Center,; NY 10016.; An anthelminthic agent, levamisole, also known as a potent immunomodulator, has been successfully used for adjuvant therapy of malignancies and chronic infections underlined by immunodeficiency. We have tested the effect of this drug on de novo viral infection by exposing MT-4 T lymphocytes to HIV in the presence of s
Construction and characterization of chimeric and humanized forms of a broadly neutralizing monoclonal antibody to HIV-1.: Hum Antibodies Hybridomas. 1994;5(1-2):9-17. Unique Identifier : AIDSLINE MED/95161669; Major JG; Liou RS; Sun LK; Yu LM; Starnes SM; Fung MS; Chang TW; Chang NT; Tanox Biosystems, Inc., Houston, TX 77025.; Murine monoclonal antibody (MAb) G3-519 has been shown to recognize a conserved neutralizing epitope in the fourth constant (C4) region of the external glycoprotein gp120 of HIV-1. Inasmuch as this antibody effectively neutralized the infectivity of diverse HIV-1 isolates, it has been selected to be developed for pass
National surveillance of dialysis associated diseases in the United States, 1992.: ASAIO J. 1994 Oct-Dec;40(4):1020-31. Unique Identifier : AIDSLINE MED/95161823; Tokars JI; Alter MJ; Favero MS; Moyer LA; Miller E; Bland LA; Investigation and Prevention Branch, Centers for Disease Control; and Prevention, Atlanta, GA 30333.; To determine trends in a number of hemodialysis associated diseases and practices, the Centers for Disease Control and Prevention, in collaboration with the Health Care Financing Administration, completed a mail survey of chronic hemodialysis centers in the United States in 1992. Of 2,
Management of tuberculosis in pregnancy.: J Assoc Acad Minor Phys. 1995;6(1):38-42. Unique Identifier : AIDSLINE MED/95161880; Henderson CE; Department of Obstetrics and Gynecology, Albert Einstein College; of Medicine, Montefiore Medical Center, Bronx, New York 10461.; In the United States , escalating rates of homelessness and human immunodeficiency virus infection have provided a background for the resurgence of Mycobacterium tuberculosis. This scourge of tuberculosis has disproportionately affected groups of reproductive-age women who have limited
Follicular dendritic cells in non-Hodgkin's lymphomas.: Leuk Lymphoma. 1994 Sep;15(1-2):33-43. Unique Identifier : AIDSLINE MED/95162028; Petrasch S; Brittinger G; Wacker HH; Schmitz J; Kosco-Vilbois M; Division of Internal Medicine, Ruhr-University of Bochum,; Germany.; Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid tissue and to non-Hodgkin s lymphomas derived from the follicular center or the mantle zone. With their cytoplasmic ramifications they form a dense network which contains the B-lymphocytes. In situ, FDC are only detectable at t
[Bone and joint sites of African histoplasmosis (Histoplasma duboisii). Apropos of a case and review of the literature]: Rev Rhum Ed Fr. 1994 Dec;61(11):829-38. Unique Identifier : AIDSLINE MED/95162125; Simon F; Chouc PY; Herve V; Branquet D; Jeandel P; Service de Medecine, Hopital Regional de Bambari, Republique; Centrafricaine (1), Marseille Armees.; The authors report a case of disseminated African histoplasmosis with bone and joint involvement in a black 28-year-old citizen of the Central African Republic who presented with a 17-month history of multiple osteoarticular lesions (sternoclavicular joints, humerus
HIV/AIDS and its interaction with tuberculosis in Latin America and the Caribbean.: Bull Pan Am Health Organ. 1994 Dec;28(4):312-23. Unique Identifier : AIDSLINE MED/95162197; Zacarias F; Gonzalez RS; Cuchi P; Yanez A; Peruga A; Mazin R; Betts C; Weissenbacher M; Pan American Health Organization, Regional Program for AIDS and; Sexually Transmitted Diseases, Washington, D.C.; At present, human immunodeficiency virus (HIV) is thought to have infected over 17 million people worldwide, over 1 million in North America and roughly 2 million in Latin America and the Caribbean. By comparison, infection with the tuberculosis (TB) agent Mycobacterium tuberculosis is far more common, current estimat
Human immunodeficiency virus-associated neoplasms: epidemiology, pathogenesis, and review of current therapy.: Cancer Pract. 1994 Jul-Aug;2(4):297-306. Unique Identifier : AIDSLINE MED/95162209; Aboulafia DM; The development of cancer in the setting of human immunodeficiency virus (HIV) infection is a devastating event and highlights the role of impaired immunity in the generation of various neoplasms. Improved strategies to suppress viral replication and prevent opportunistic infections generally have enabled patients wit
Human immunodeficiency virus medicine for the MRCP long case and viva.: Br J Hosp Med. 1994 Oct 5-18;52(7):335-8. Unique Identifier : AIDSLINE MED/95162386; Nandwani R; Claude Nicol Centre, Royal Sussex County Hospital, Brighton.; Doctors should consider human immunodeficiency virus (HIV) disease as a possibility in patients both in the MRCP clinical examination and during daily clinical practice. Aspects relating to the MRCP long case and viva are dealt with in this article.
Lessons from the Concorde trial [editorial]: Br J Hosp Med. 1994 Oct 19-Nov 1;52(8):378-9. Unique Identifier : AIDSLINE MED/95162399; Peto T; Darbyshire J
Is the increase in tuberculosis an epidemic? [letter]: Br J Hosp Med. 1994 Oct 19-Nov 1;52(8):419. Unique Identifier : AIDSLINE MED/95162408; Crofton J
Public policy implications of HIV/AIDS in adolescents.: Future Child. 1994 Winter;4(3):73-93. Unique Identifier : AIDSLINE MED/95162683; Blair JF; Hein KK; Adolescent AIDS Program, Albert Einstein College of Medicine.
Uptake and binding of liposomal 2',3'-dideoxycytidine by RAW 264.7 cells: a three-step process.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):227-35. Unique Identifier : AIDSLINE MED/95162788; Makabi-Panzu B; Lessard C; Beauchamp D; Desormeaux A; Poulin L; Tremblay M; Bergeron MG; Laboratoire et Service d'Infectiologie, Centre Hospitalier,; Universite Laval, Quebec, Canada.; It was recently reported that the sequestration of virus by macrophages in reticuloendothelial system organs, such as lymph nodes, is possibly responsible for the clinical latency of disease in asymptomatic HIV-infected patients. Since macrophages may sequester HIV after phagocytosis, and because phagocytosis is a spe
Incidence and prognostic value of malnutrition and wasting in human immunodeficiency virus-infected outpatients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):239-46. Unique Identifier : AIDSLINE MED/95162790; Suttmann U; Ockenga J; Selberg O; Hoogestraat L; Deicher H; Muller MJ; Medizinische Hochschule Hannover, Abt. Immunologie, Germany.; Although malnutrition and wasting are known features of human immunodeficiency virus (HIV) infection, their incidence and possible association with immunologic impairment are largely unknown, as is the prognostic value of the nutritional state. Nutritional, clinical, and immunologic parameters were measured in 100 out
The role of atovaquone tablets in treating Pneumocystis carinii pneumonia.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):247-52. Unique Identifier : AIDSLINE MED/95162791; Hughes WT; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee 38101-0318.; At the start of the AIDS epidemic, the only agents licensed for treatment of Pneumocystis carinii pneumonia (PCP) were trimethoprim-sulfamethoxazole (TMP-SMX) and pentamidine. Both are effective against PCP, but their use has been compromised by adverse reactions that necessitate discontinuing therapy in
Derivation and properties of a brief health status assessment instrument for use in HIV disease.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):253-65. Unique Identifier : AIDSLINE MED/95162792; Bozzette SA; Hays RD; Berry SH; Kanouse DE; Wu AW; Health Sciences Program, RAND, Santa Monica, CA 90407.; Health status measures adapted from the Medical Outcomes Study (MOS) scales have been shown to be useful and highly reliable in human immunodeficiency virus-infected populations, but acceptance of these measures has been limited in part by concerns over investigator, patient, and data burden. We sought to address thes
Serum beta 2-microglobulin and prediction of progression to AIDS in HIV-infected injection drug users.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):266-72. Unique Identifier : AIDSLINE MED/95162793; Zabay JM; Sempere JM; Benito JM; Gonzalez B; Obregon E; Diez J; Fernandez-Cruz E; Department of Immunology, University General Hospital Gregorio; Maranon, Complutense University, Madrid, Spain.; Several immunological and serological variables have become established in recent studies as valuable markers to identify human immunodeficiency virus (HIV)-positive individuals at the highest risk for rapid disease progression. These studies have been performed mainly in cohorts of homosexual men. In this study, we a
HIV Dementia Scale: a rapid screening test.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):273-8. Unique Identifier : AIDSLINE MED/95162794; Power C; Selnes OA; Grim JA; McArthur JC; Department of Neurology, Johns Hopkins University, Baltimore,; Maryland.; HIV dementia has an annual incidence of 7% after AIDS development and eventually affects 20% of all HIV-infected persons. Accurate and early diagnosis of HIV dementia can lead to optimized therapeutic and management decisions. The purpose of this study was to design a valid instrum
Safety and efficacy of thymopentin in zidovudine (AZT)-treated asymptomatic HIV-infected subjects with 200-500 CD4 cells/mm3: a double-blind placebo-controlled trial.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):279-88. Unique Identifier : AIDSLINE MED/95162795; Goldstein G; Conant MA; Beall G; Grossman HA; Galpin JE; Blick G; Calabrese LH; Hirsch RL; Fisher A; Stampone P; et al; Immunobiology Research Institute, Annandale, New Jersey.; Thymopentin, 50 mg subcutaneously (s.c.) 3 times per week, was evaluated in a double-blind, randomized, placebo-controlled trial of zidovudine ( AZT )-treated asymptomatic human immunodeficiency virus (HIV)-infected subjects with 200-500 CD4 cells/mm3 a
Failure of high-dose oral acyclovir to suppress CMV viruria or induce ganciclovir-resistant CMV in HIV antibody positive patients.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):289-91. Unique Identifier : AIDSLINE MED/95162796; Drew WL; Anderson R; Lang W; Miner RC; Davis G; Lalezari J; Mount Zion Medical Center, University of California at San; Francisco 94120.; Ninety-three symptomatic HIV antibody positive patients were randomized to receive zidovudine (ZDV) 600 mg/day and acyclovir (ACV) 4,800 mg orally per day versus ZDV 600 mg/day plus placebo. Urine was obtained at 3-month intervals and cultured for
AIDS among the homeless of Boston: a cohort study.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):292-6. Unique Identifier : AIDSLINE MED/95162797; Lebow JM; O'Connell JJ; Oddleifson S; Gallagher KM; Seage GR 3rd; Freedberg KA; Boston Health Care for the Homeless Program, Boston City; Hospital, MA 02118.; We wanted to compare demographics, risk behaviors, AIDS-defining diagnoses, and survival between homeless and housed persons with AIDS in Boston from 1983 to 1991. Our retrospective cohort study used chart review to identify homeless AIDS cases and data from the Massachusetts AIDS Surveillance Program for comparison o
Trends in incidence and prevalence of HIV-1 infection in intravenous drug users in Valencia, Spain.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):297-301. Unique Identifier : AIDSLINE MED/95162798; Rebagliato M; Avino MJ; Hernandez-Aguado I; Ruiz I; Perez-Hoyos S; Bolumar F; Ferrer L; Instituto Valenciano de Estudios en Salud Publica (IVESP),; Valencia, Spain.; Our objective was to describe and compare the trends of incidence and prevalence of HIV-1 infection in intravenous drug users (IDUs) in Valencia, Spain in 1987-1992. A cohort study was carried out in AIDS Information Centers located in the Valencia Region (Spain). Point seroprevalen
Apparent deficiency of glutathionine in the PBMC's of people with AIDS depends on method of expression [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):313-4. Unique Identifier : AIDSLINE MED/95162800; Barditch-Crovo P; Svobodova V; Lietman P
Flank abscess in AIDS and tuberculosis [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):315. Unique Identifier : AIDSLINE MED/95162801; Ajuluchuku EU; Harry TO; Eni EU
Regional differences in human retroviral infections HIV-1, HIV-2, and HTLV-I/II in rural Guinea (west Africa) [letter]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Mar 1;8(3):315-8. Unique Identifier : AIDSLINE MED/95162802; Jeannel D; Kourouma K; Fretz C; Zheng YM; Ureta VA; Drame L; Gessain A; Fournel JJ; de The G
Periodic health examination, 1995 update: 1. Screening for human papillomavirus infection in asymptomatic women. Canadian Task Force on the Periodic Health Examination.: Can Med Assoc J. 1995 Feb 15;152(4):483-93. Unique Identifier : AIDSLINE MED/95162993; Johnson K; Department of Preventive Medicine and Biostatistics, University; of Toronto, Ont.; OBJECTIVE: To develop recommendations for practising physicians on the advisability of screening for human papillomavirus (HPV) infection in asymptomatic women. OPTIONS: Visual inspection, Papanicolaou testing, colposcopy or cervicography, use of HPV group-specific antigen, DNA hybridization, dot blot technique, South
What happens to donated blood?: Can Med Assoc J. 1995 Feb 15;152(4):521-4. Unique Identifier : AIDSLINE MED/95162997; Robinson A; Pursuing their chief work--gathering, processing and distributing blood--the blood donor centres of the Canadian Red Cross Society follow standard operating procedures like those in place at the Ottawa centre. Here, recruitment staff and volunteers work to recruit donors to meet needs at a time when the number of dono
[Survey on the current situation of epidemic of HIV infection in Yunnan Province]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1994 Oct;15(5):259-62. Unique Identifier : AIDSLINE MED/95163064; Zhang J; Cheng H; Duan S; Yunnan Provincial Health & Anti-epidemic Center, Kunming.; This paper summarized the results of routine surveillance, sentinel surveillance in Yunnan province during the period of 1986 to 1992. In 1992, HIV infection rates of intravenous drug users (IDUs) were 80.7% in Ruili city, 43.0% in Longchuan county, 17.4% in Yinjiang county, 3.7% in Luxi county and 0 in Kunming city r
Condom use and the risk of HIV infection: who is being protected?: Cent Afr J Med. 1994 Nov;40(11):294-9. Unique Identifier : AIDSLINE MED/95163079; Mbizvo MT; Ray S; Bassett M; McFarland W; Machekano R; Katzenstein D; Department of Community Medicine, University of Zimbabwe Medical; School, Avondale, Harare.; Descriptive baseline data at enrollment into a cohort of male factory workers who were tested for HIV serology and monitored for sero-conversion over time, were analysed for condom use. At recruitment, the 1,146 men were asked about their sexual behaviour, history of sexually transmitted diseases (STDs), condom use an
HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator.: Cell. 1995 Feb 10;80(3):379-88. Unique Identifier : AIDSLINE MED/95163091; Gallay P; Swingler S; Aiken C; Trono D; Infectious Disease Laboratory, Salk Institute for Biological; Studies, La Jolla, California 92037.; The HIV-1 matrix (MA) protein contains two subcellular localization signals with opposing effects. A myristoylated N-terminus governs particle assembly at the plasma membrane, and a nucleophilic motif facilitates import of the viral preintegration complex into the nucleus of nondividing cells. Here, we show that myris
Human recombinant IL-2 augments immunoglobulin and induces rheumatoid factor production by rheumatoid arthritis lymphocytes engrafted into severe combined immunodeficient mice.: Clin Immunol Immunopathol. 1995 Mar;74(3):271-82. Unique Identifier : AIDSLINE MED/95163249; Kaul R; Sharma A; Lisse JR; Christadoss P; Department of Microbiology and Immunology, University of Texas; Medical Branch, Galveston 77555.; Recombinant (r) human IL-2 was administered in vivo to improve homing and engraftment of rheumatoid arthritis (RA) patients peripheral blood mononuclear cells (PBMC) into severe combined immunodeficient (SCID) mice. Human rIL-2 treatment resulted in augmented human Ig
Cutaneous herpes simplex virus infection in a child with acquired immunodeficiency syndrome.: Clin Pediatr (Phila). 1994 Nov;33(11):698-700. Unique Identifier : AIDSLINE MED/95163266; Choudhury SA; Hodes DS; Peters VB; Bottone EJ
Bone banking in Denmark, results of a nationwide survey.: Dan Med Bull. 1994 Nov;41(5):574-6. Unique Identifier : AIDSLINE MED/95163357; Hansen CA; Mejdahl S; Reimann I; Department of Orthopaedic Surgery, Herlev Hospital.; In a nationwide survey, all orthopaedic clinics were surveyed via a questionnaire about the use of bone allografts and how they managed their bone banks. Thirty-two clinics (100 per cent) responded to the questionnaire (mid 1991). Seventeen clinics had established bone banks on the basis of femoral heads obtained from
Inflammatory fibroid polyp of the esophagus in an HIV-infected individual: case study.: Dysphagia. 1995 Winter;10(1):59-61. Unique Identifier : AIDSLINE MED/95163371; Simmons MZ; Cho KC; Houghton JM; Levine CD; Javors BR; Department of Radiology, University Hospital, UMD-New Jersey; Medical School, Newark.; We report an unusual case of a large esophageal inflammatory fibroid polyp in a man infected with the human immunodeficiency virus complaining of dysphagia. Barium studies and computed tomography demonstrated a long, submucosal-appearing, distal esophageal mass which extended into a hiatal hernia. Inflammatory fibroid
An intervention to reduce the risk of mother-to-infant HIV transmission: results of a pilot toxicity study.: East Afr Med J. 1994 Nov;71(11):712-5. Unique Identifier : AIDSLINE MED/95163490; Taha TE; Justesen A; Paterson K; Mtimavalye LA; Munthali P; Canner JK; Broadhead RL; Chiphangwi JD; Miotti PG; Biggar RJ; Johns Hopkins University-Ministry of Health Research Project,; Blantyre, Malawi.; Although unproven, vaginal cleansing with antiseptics during labour could be a practical approach to reducing the rate of transmission of HIV infection from mother to infant. Before initiating a large scale clinical trial of the antiseptic chlorhexidine, we conducted a study to assess possible toxic effects as well as
Secondary school students: a safer blood donor population in an urban with high HIV prevalence in east Africa.: East Afr Med J. 1994 Nov;71(11):720-3. Unique Identifier : AIDSLINE MED/95163492; Jacobs B; Berege ZA; Schalula PJ; Klokke AH; Bugando Medical Centre, Mwanza, Tanzania.; We evaluated the enrollment of secondary school students as voluntary unremunerated blood donors in a city where the HIV-1 prevalence among the adult population is 11.8%. Between 1st July, 1992 and 1st December, 1993, consecutive blood donors were screened for anti-HIV-1, TPHA, HBsAg and anti-HBc. Test results were re
Absence of neutropenia in African patients with AIDS and associated pyomyositis.: East Afr Med J. 1994 Nov;71(11):736-8. Unique Identifier : AIDSLINE MED/95163495; Ansaloni L; Acaye GL; Ambrosoli Memorial Hospital, Kalongo, Kitgum District, Uganda.; The association between AIDS and pyomyositis was recently pointed out in temperate and tropical countries. In Western countries, the patients affected by pyomyositis associated with AIDS in most cases are neutropenic. We compare a group of 17 patients with pyomyositis and AIDS living in temperate climates from the lit
Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.: EMBO J. 1995 Feb 1;14(3):484-91. Unique Identifier : AIDSLINE MED/95163581; Saksela K; Cheng G; Baltimore D; Rockefeller University, New York, NY 10021.; Human immunodeficiency virus (HIV) and simian immunodeficiency virus Nef proteins contain a conserved motif with the minimal consensus (PxxP) site for Src homology region 3 (SH3)-mediated protein-protein interactions. Nef PxxP motifs show specific binding to biotinylated SH3 domains of Hck and Lyn, but not to those of
HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.: EMBO J. 1995 Feb 1;14(3):546-54. Unique Identifier : AIDSLINE MED/95163587; Westendorp MO; Shatrov VA; Schulze-Osthoff K; Frank R; Kraft M; Los M; Krammer PH; Droge W; Lehmann V; Division of Immunogenetics, German Cancer Research Center,; Heidelberg.; This study demonstrates that human immunodeficiency virus type 1 (HIV-1) Tat protein amplifies the activity of tumor necrosis factor (TNF), a cytokine that stimulates HIV-1 replication through activation of NF-kappa B. In HeLa cells stably transfected with the HIV-1 tat gene (HeLa-tat cells), expression of the Tat pro
Renal aspergilloma, a rare manifestation in AIDS.: Eur J Radiol. 1994 Nov;19(1):19-20. Unique Identifier : AIDSLINE MED/95163599; Guadano V; Corral B; Alegre N; Montero AI; Servicio de Radiodiagnostico, Hospital Severo Ochoa, Madrid,; Spain.
Molecular subtypes of env sequences around V3 region of human immunodeficiency virus type 1 in Taiwan.: Eur J Epidemiol. 1994 Jun;10(3):247-50. Unique Identifier : AIDSLINE MED/95163682; Chang KS; Lin CI; Ling P; Lin KH; Lin HC; Twu SJ; Graduate Institute of Clinical Medicine, Chang Gung Medical; College, Taoyuan-Hsien, Taipei, Taiwan.; Samples of peripheral blood mononuclear cells (PBMC) were collected during 1990-91 from seropositive healthy, male HIV-1 carriers visiting Taipei Venereal Disease Control Center, and a male AIDS patient admitted to a general hospital. The V3 and its flanking nucleotide (nt) sequences in their DNA were amplified by pol
HCV, HIV, HBV and HDV infections in intravenous drug addicts.: Eur J Epidemiol. 1994 Jun;10(3):279-83. Unique Identifier : AIDSLINE MED/95163687; Coppola RC; Manconi PE; Piro R; Di Martino ML; Masia G; Istituto di Igiene e Medicina Preventiva, Universita degli Studi; di Cagliari, Italy.; Hepatitis viruses and the acquired immunodeficiency viruses often infect intravenous drug addicts (IVDAs). Our study includes 255 IVDAs (26 females and 229 males, aged 20-35 years) from Cagliari. Of 255 subjects examined, 207 (81.1%) were positive for anti-HCV and 84 (32.9%) for anti-HIV. Nineteen (7.4%) subjects were
HIV epidemiology and risk behavior promoting HIV transmission in Austrian prisons.: Eur J Epidemiol. 1994 Jun;10(3):285-9. Unique Identifier : AIDSLINE MED/95163688; Pont J; Strutz H; Kahl W; Salzner G; Bundesministerium fur Justiz, Wien, Austria.; In 1989, 1990 and 1992, 19%, 15% and 10%, respectively, of all prisoners newly admitted to prisons and penitentiary institutions in Austria underwent HIV antibody tests. Based on the HIV test outcome in prisons in which more than 80% of the newly admitted inmates were tested, annu
Helicobacter pylori seroepidemiology in risk groups.: Eur J Epidemiol. 1994 Jun;10(3):299-301. Unique Identifier : AIDSLINE MED/95163690; Quiros A; Quiros E; Gonzalez I; Bernal MC; Piedrola G; Maroto MC; Microbiology Department, Faculty of Medicine, Granada University,; Spain.; Helicobacter pylori is associated with peptic ulcer and chronic active gastritis. The response to infection can be determined by measuring serum titers of anti-H. pylori antibodies. We compared antibody titers in 612 serum samples from 570 individuals considered at risk for H. pylori infection, 170 of them are control
The HIV prevalence among pregnant women in the Amsterdam region (1988-1991).: Eur J Epidemiol. 1994 Jun;10(3):331-8. Unique Identifier : AIDSLINE MED/95163695; Bindels PJ; Mulder-Folkerts DK; Boer K; Schutte MF; van der Velde Wj; Wong FJ; van den Hoek AJ; van Doornum GJ; Coutinho RA; Municipal Health Service, University of Amsterdam.; The objective of the study was to monitor the HIV prevalence in the years 1988-1991 among pregnant women in the Amsterdam region, visitors to an abortion clinic and 3 outpatient infertility clinics. All women attending these clinics were asked to participate in the study on a voluntary basis and were tested with infor
Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis.: Eur J Haematol. 1995 Jan;54(1):1-8. Unique Identifier : AIDSLINE MED/95163721; Diez-Ruiz A; Tilz GP; Zangerle R; Baier-Bitterlich G; Wachter H; Fuchs D; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.; Soluble tumour necrosis factor receptors (sTNF-Rs) play a role as modulators of the biological function of tumour necrosis factor-alpha (TNF-alpha) in an agonist/antagonist pattern. In various pathologic states the production and release of sTNF-Rs may mediate host response and determine the course and outcome of dise
Monoclonal antibodies against a synthetic peptide from human immunodeficiency virus type 1 Nef protein.: Hybridoma. 1994 Oct;13(5):383-8. Unique Identifier : AIDSLINE MED/95163969; Steinaa L; Wulff AM; Saermark T; Department of Infectious Diseases, Hvidovre Hospital, Denmark.; Monoclonal antibodies against a synthetic peptide (aa 138-152) from HIV-1 Nef protein were produced and characterized. Three hybridoma lines producing mono