An in vivo AIDS-related lymphoma model for assessing chemotherapeutic agents (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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An in vivo AIDS-related lymphoma model for assessing chemotherapeutic agents (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 35:A2198 1994. Unique Identifier : AIDSLINE ICDB/95603884
Grever MR; Giavazzi R; Anver M; Hollingshead MG; Mayo JG; Malspeis L; Developmental Therapeutics Program, Bethesda, MD 20892

Abstract: A Burkitt's lymphoma cell line (AS-283), derived from a 23 year-old male AIDS patient, has been established as a xenograft in mice. The cells are positive for Epstein-Barr virus and negative for the HIV genome. These cells were administered to SCID, NIH-III (bg/nu/xid) and athymic (nu/nu) mice by the intraperitoneal, subcutaneous and intravenous routes. Tumor growth is most consistent in SCID mice. Intravenous inoculation results in tumors in the lungs, brain, bone marrow, nasal turbinates, spleen, spinal cord and lymph nodes. Intraperitoneal inoculation results in intraperitoneal tumor growth as well as involvement of extra-abdominal sites. Subcutaneous inoculation produces detectable tumor masses within 7-10 days post-inoculation. Clinically relevant antineoplastic agents (methotrexate, doxorubicin, cyclophosphamide) were assessed for efficacy in the subcutaneous and intraperitoneal tumor systems. Highly significant antitumor activity was seen with methotrexate and cyclophosphamide, while doxorubicin was less active on the treatment schedules assessed in these studies. The NCI has developed this model specifically for the purpose of identifying new agents for this AIDS-related malignancy.
Keywords: Adult Cell Transformation, Neoplastic Cyclophosphamide/THERAPEUTIC USE Doxorubicin/THERAPEUTIC USE Human Lymphoma, AIDS-Related/*DRUG THERAPY/PATHOLOGY Male Methotrexate/THERAPEUTIC USE Mice Mice, Nude Mice, SCID ABSTRACTKWDadultcelltransformation,neoplasticcyclophosphamide/therapeuticusedoxorubicin/therapeuticusehumanlymphoma,aids-related/KWDdrugtherapy/pathologymalemethotrexate/therapeuticusemicemice,nudemice,scidabstract
950330
M9530850

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