Antitumor activity of propolis extracted as micro-capsulated micelles (Meeting abstract).

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Antitumor activity of propolis extracted as micro-capsulated micelles (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 35:A2449 1994. Unique Identifier : AIDSLINE ICDB/95604134
Matsuno T; Dept. of Virus Res. and Vaccine Control, Natl. Inst. of Health,; Musashinurayama, Tokyo 208, Japan

Abstract: The honeybee hive product, propolis, is a folk medicine employed for treating various ailments. It is alleged to exhibit a broad spectrum of activities including antibiotic, anti-inflammation, antioxidant and tumor growth arrest. We have isolated a new clerodane diterpenoid from Brazilian propolis which inhibited DNA polymerase alpha activity and damaged various tumor cells. An excellent method of extracting propolis as micelles with fatty acid esters has been devised to facilitate the absorption. Effect of the ingestion of this extract was investigated in cancer patients. The extract (30 to approx 40 ml/day) was harmless, and many patients felt they were physically in better condition. Immunological analyses of the peripheral lymphocyte subsets were carried out by cytofluorography. A promotive effect was frequently observed on the number of lymphoid cells with natural killer subsets (especially CD57- CD16+ and CD57+ CD16+) and CD3+ HLA-DR-. The extract considerably remitted various adverse effects of chemotherapy and radiation such as depletion of WBC and occurrence of inflammation of oral mucosa, nausea or falling-out of hair. Furthermore, it improved the survival and quality of life for many patients.

Keywords: Capsules Killer Cells, Natural/DRUG EFFECTS Micelles Neoplasms/DRUG THERAPY Propolis/ISOLATION & PURIF/*PHARMACOLOGY/THERAPEUTIC USE ABSTRACT
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M9530847

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