Anticancer activity of Morinda citrifolia (noni) on intraperitoneally implanted Lewis lung carcinoma and retroviral leukemia in mice (Meeting abstract).

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Anticancer activity of Morinda citrifolia (noni) on intraperitoneally implanted Lewis lung carcinoma and retroviral leukemia in mice (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 35:A2854 1994. Unique Identifier : AIDSLINE ICDB/95604539
Hirazumi A; Furusawa E; Chou SC; Hokama Y; Dept. of Pharmacology, Univ. of Hawaii, Honolulu, HI 96822

Abstract: The fruit juice of noni has been found to be therapeutically active against ip implanted Lewis lung carcinoma (LLC) in syngeneic C57BL/6 mice. The antitumor principle(s), which was concentrated in the ethanol-precipitable (EtOH-ppt) fraction, increased the survival time of mice by 123% (MST of control = 14.7 days vs MST of treated = 32.7; number of survivors of control = 0/34 mice vs number of survival of treated = 15/34) when administered ip (35 mg/kg) every other day, starting on day 1 or 2. The EtOH-ppt was noncytotoxic in KB cell cultures. Concomitant treatment with 2-chloroadenosine or cyclosporine resulted in the abrogation of the antitumor activity of the EtOH-ppt, suggesting the antitumor activity acts via activation of host-immune system. Chemoimmunotherapy of vincristine, 5-fluorouracil, cisplatin, or Adriamycin combined with the EtOH-ppt demonstrated beneficial additive or synergistic effects. Preliminary data show production of interleukin-1, but not interleukin-2, from cell culture supernatant of human peripheral mononuclear cells. Antiviral studies using Rauscher murine retrovirus, a convenient model for HIV studies, show inhibition of leukemic splenomegaly in BALB/c mice inoculated with the virus.

Keywords: Animal Antineoplastic Agents/THERAPEUTIC USE Cyclosporine/THERAPEUTIC USE *Fruit Interleukin-1/METABOLISM Interleukin-2/METABOLISM Leukemia/IMMUNOLOGY/THERAPY Mice Mice, Inbred C57BL *Plants, Medicinal Retroviridae Infections/IMMUNOLOGY/THERAPY Tumor Virus Infections/IMMUNOLOGY/THERAPY 2-Chloroadenosine/THERAPEUTIC USE ABSTRACT
950330
M9530838

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