Biological effects of propolis on macrophage function and tumor growth (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Biological effects of propolis on macrophage function and tumor growth (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 35:A2938 1994. Unique Identifier : AIDSLINE ICDB/95604623
Hanaya T; Arai S; Kawai S; Nii A; Yoshida K; Kurimoto M; Minowada J; Fujisaki Institute, Hayashibara Biochem. Labs., Inc., Okayama; 702, Japan

Abstract: Propolis, bee glue obtained from bee hives, is known as a home remedy because of its antimicrobial and antiviral effects. We prepared propolis powder with anhydrous maltose to facilitate its solubility (propolis content: approx 13.7%). Murine macrophage functions, such as cell adhesion and the subsequent spreading of the cytoplasm, and the motility and phagocytosis of macrophages were significantly activated in vitro with propolis at concentrations of 0.03-1.0 mg/ml. In vitro dose-dependent growth inhibition of several human and murine tumor cell lines, but not non-tumor cell lines, was observed in the presence of 0.03 to 1.0 mg/ml of propolis. Using an experimental metastasis model with the Colon 26 adenocarcinoma cell line, BALB/c mice were given 3 iv injections of 0.1-0.4 mg propolis per mouse before and after the transplantation of tumor cells. The results showed that only the group pretreated with 0.2 mg of propolis demonstrated a significant reduction (35%) in lung metastasis compared with that of the control group. These observations indicate that propolis has BRM-like antitumor activities. A single low molecular weight fraction with this activity has been partially purified and identified.
Keywords: Adenocarcinoma/*DRUG THERAPY/SECONDARY Animal Colonic Neoplasms/*DRUG THERAPY Macrophages/*DRUG EFFECTS/*IMMUNOLOGY/PHYSIOLOGY Mice Mice, Inbred BALB C Neoplasm Transplantation Propolis/*PHARMACOLOGY/THERAPEUTIC USE ABSTRACTKWDadenocarcinoma/KWDdrugtherapy/secondaryanimalcolonicneoplasms/KWDdrugtherapymacrophages/KWDdrugeffects/KWDimmunology/physiologymicemice,inbredbalbcneoplasmtransplantationpropolis/KWDpharmacology/therapeuticuseabstract
950330
M9530836

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