Interleukin-10 production by lymphoma cells in vivo: role of EBV (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Interleukin-10 production by lymphoma cells in vivo: role of EBV (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 35:A3141 1994. Unique Identifier : AIDSLINE ICDB/95604826
Voorzanger N; Touitou R; Joab I; Edelman L; Burdin N; Rousset F; Favrot M; Blay JY; Centre L. Berard, Lyon, France

Abstract: We have previously reported that serum interleukin 10 (IL-10) is increased in patients (pts) with non-Hodgkin's lymphoma (NHL) and correlates to a poor prognosis. Here, we have investigated the cellular source of IL-10 and the possible relationship with EBV infection in non-HIV related NHL and Hodgkin's disease (HD). Immunostaining with 85, an anti-IL-10 antibody (Ab) recognizing both human and EBV IL-10 (vIL10) was performed in tumor samples of 37 pts with NHL and 7 pts with HD. IL-10 was detectable in 24 of 37 (65%) NHL and 5 of 7 (71%) HD. Pts with detectable serum IL-10 had consistently a positive staining for 85, suggesting that tumor cells are the source of circulating IL-10. Presence of IL-10 did not correlate to histological subtype, T/B phenotype and clinical stage. Using immunostainings with the 65 Ab (specific for vIL10), vIL-10 was detectable in 6 of 37 (16%) NHL and 1 of 7 (14%) HD pts. In situ hybridization using EBER probes, characteristic of latent EBV infection, showed that 17 NHL and 4 HD pts had EBER+ tumors. vIL-10+ tumors were consistently found EBER+ (p=0.004), whereas hIL-10 was detected in both EBER+ and EBER- NHL or HD. In conclusion, hIL-10 and/or vIL-10 are produced in vivo by malignant cells in the majority of pts with NHL and HD. Different biological mechanisms, including EBV, are involved in the deregulation of IL-10 production by NHL malignant cells.
Keywords: Herpesvirus 4, Human Hodgkin's Disease/*METABOLISM Human Interleukin-10/*METABOLISM Lymphoma, Non-Hodgkin's/*METABOLISM ABSTRACTKWDherpesvirus4,humanhodgkin'sdisease/KWDmetabolismhumaninterleukin-10/KWDmetabolismlymphoma,non-hodgkin's/KWDmetabolismabstract
950330
M9530832

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