Circulating immune complexes in patients with psoriasis: do they exist? NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Circulating immune complexes in patients with psoriasis: do they exist?

Exp Dermatol. 1992 Oct;1(3):149-51. Unique Identifier : AIDSLINE MED/95093795
Hunziker T; Kolmar A; Spath PJ; Braathen LR; Dermatological Clinic, University of Berne, Switzerland.

Abstract: Sera from 16 patients suffering from active psoriasis without arthropathy (2 guttate, 10 nummular, and 4 mixed type) were examined for the presence of circulating immune complexes. Five routine laboratory assay systems were used, based on C1q-binding or detection of IgG-coupled C1q and C3-breakdown products. In 14 patients, no elevated levels of circulating immune complexes were detected. One patient, who additionally suffered from late-phase HIV-1 infection, showed C1q-binding activities as well as levels of IgG-coupled C1q and C3-breakdown products in four of the assay systems, which indicated the presence of immune complexes in his serum. In another patient, with nummular psoriasis, slightly elevated levels of circulating immune complexes were measured by two of the assay systems. These results question the hypothesis of an essential pathogenic role of circulating immune complexes in psoriasis.
Keywords: Adult Aged Aged, 80 and over Antigen-Antibody Complex/*ANALYSIS Complement 1q/IMMUNOLOGY Complement 3/IMMUNOLOGY Female Human IgG/IMMUNOLOGY Immunologic Techniques Male Middle Age Psoriasis/*IMMUNOLOGY Reference Values JOURNAL ARTICLEKWDadultagedaged,80andoverantigen-antibodycomplex/KWDanalysiscomplement1q/immunologycomplement3/immunologyfemalehumanigg/immunologyimmunologictechniquesmalemiddleagepsoriasis/KWDimmunologyreferencevaluesjournalarticle
950330
M9530810

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