Role of bcl-2 and apoptosis in viral infections. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Role of bcl-2 and apoptosis in viral infections.

Int Arch Allergy Immunol. 1994 Dec;105(4):359-62. Unique Identifier : AIDSLINE MED/95072471
Akbar AN; Salmon M; Janossy G; Department of Clinical Immunology, Royal Free Hospital School of; Medicine, London, UK.

Abstract: For decades immunobiologists have focussed on lymphocyte activation leading to cellular proliferation as a means by which the numbers of antigen-responsive cells can be increased. The pendulum has now swung back and questions are being raised about the way in which the size of the activated lymphocyte populations, such as those found during certain acute viral infections, can be controlled. The process of apoptosis has gained widespread recognition as a physiological means by which unwanted cells can be removed. In this review we will discuss recent observations on the control of apoptosis in the activated and expanded T cell populations found during viral infections and how this process co-exists with certain mechanisms which enable the retention of the fittest cells which can participate in subsequent encounters with virus.
Keywords: Animal Apoptosis/*IMMUNOLOGY CD8-Positive T-Lymphocytes/*PHYSIOLOGY Human Immunologic Memory Proto-Oncogene Proteins/GENETICS/*PHYSIOLOGY Virus Diseases/*IMMUNOLOGY JOURNAL ARTICLEKWDanimalapoptosis/KWDimmunologycd8-positivet-lymphocytes/KWDphysiologyhumanimmunologicmemoryproto-oncogeneproteins/genetics/KWDphysiologyvirusdiseases/KWDimmunologyjournalarticle
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M9530792

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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