Interleukin-2 and interferon-gamma production by peripheral blood lymphocytes of patients with common variable immunodeficiency. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Interleukin-2 and interferon-gamma production by peripheral blood lymphocytes of patients with common variable immunodeficiency.

J Investig Allergol Clin Immunol. 1994 May-Jun;4(3):122-5. Unique Identifier : AIDSLINE MED/95072797
Inoue Y; Kondo N; Motoyoshi F; Inoue R; Orii T; Department of Pediatrics, Gifu University School of Medicine,; Japan.

Abstract: We evaluated the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) in peripheral blood lymphocytes (PBLs) from six patients with common variable immunodeficiency (CVID). IL-2 production and IFN-gamma concentrations were not reduced in these patients. As the production of IL-2 and IFN-gamma secreted from TH1 clones was within the normal range in patients with CVID, we concluded that TH1 function was normal in these patients. Our previous report showed B-cell dysfunction in CVID patients. Therefore, we concluded that the immune defect in these patients is caused by B-cell dysfunction rather than T-cell dysfunction.
Keywords: Adult B-Lymphocytes/PATHOLOGY Child Child, Preschool Comparative Study Concanavalin A/PHARMACOLOGY Human Immunologic Deficiency Syndromes/*BLOOD Immunophenotyping Interferon Type II/*BIOSYNTHESIS Interleukin-2/*BIOSYNTHESIS Lymphocyte Transformation/DRUG EFFECTS Male Phytohemagglutinins/PHARMACOLOGY Receptors, Interleukin-2/BIOSYNTHESIS Th1 Cells/*METABOLISM JOURNAL ARTICLEKWDadultb-lymphocytes/pathologychildchild,preschoolcomparativestudyconcanavalina/pharmacologyhumanimmunologicdeficiencysyndromes/KWDbloodimmunophenotypinginterferontypeii/KWDbiosynthesisinterleukin-2/KWDbiosynthesislymphocytetransformation/drugeffectsmalephytohemagglutinins/pharmacologyreceptors,interleukin-2/biosynthesisth1cells/KWDmetabolismjournalarticle
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M9530791

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