The HIV-1 nef gene acts as a positive viral infectivity factor. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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The HIV-1 nef gene acts as a positive viral infectivity factor.

Trends Microbiol. 1994 Aug;2(8):294-8. Unique Identifier : AIDSLINE MED/95072939
Miller MD; Feinberg MB; Greene WC; Gladstone Institute of Virology and Immunology, San Francisco, CA; 94141.

Abstract: The gene product of the nef gene of HIV-1 acts both to increase the infectivity of viral particles and to reduce the expression of the CD4 receptor molecule on the cell surface. These two functions of Nef may be related, in that downregulation of CD4 may promote the production of HIV that has greater infectivity.
Keywords: Animal Antigens, CD4/METABOLISM Down-Regulation (Physiology) Genes, nef/*PHYSIOLOGY Hela Cells Human HIV Infections/*VIROLOGY HIV-1/*GENETICS/PHYSIOLOGY/*PATHOGENICITY Lymphocyte Transformation Macaca mulatta Support, Non-U.S. Gov't Virus Replication JOURNAL ARTICLEKWDanimalantigens,cd4/metabolismdown-regulation(physiology)genes,nef/KWDphysiologyhelacellshumanhivinfections/KWDvirologyhiv-1/KWDgenetics/physiology/KWDpathogenicitylymphocytetransformationmacacamulattasupport,non-uKWDsKWDgov'tvirusreplicationjournalarticle
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M9530790

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