Abstract:
A longitudinal study was carried out on 19 recipients of cadaveric renal allografts, monitoring their anti-donor and anti-third party responses in the mixed lymphocyte reaction (MLR) at the time of transplantation and at 3, 6, and 12 months post-transplant. Two patterns of responses were identified: in the first (n = 11), patients showed, or later developed, donor-specific hyporesponsiveness, and in the second (n = 8), patients had persistent antidonor and anti-third party responses. After 1 year, the serum creatinine, number of episodes of acute rejection and biopsy findings were compared in both groups. In the first group, the mean serum creatinine was 136.4 mmol/l, the total number of acute rejection episodes was three and in nine of the ten available biopsies, there were minimal cellular infiltrates and normal appearance of the glomeruli, tubules and blood vessels. In the second group, the mean serum creatinine was 163 mmol/l, the total number of acute rejection episodes was 12 and in five of the seven biopsies available, evidence of ongoing rejection was obtained. The difference in mean serum creatinine was not statistically significant (P > 0.05), but the difference in the numbers of acute rejection episodes was (P < 0.05). It is concluded that in some renal allograft recipients, a state of donor-specific hyporesponsiveness develops, and this state may be associated with better graft outcome at 1 year. These data may be useful in selecting patients for reduced immunosuppressive therapy.
Keywords: Acute Disease Adult Creatinine/BLOOD CD8-Positive T-Lymphocytes/IMMUNOLOGY Female Graft Rejection/BLOOD/IMMUNOLOGY Human IgG/IMMUNOLOGY/ISOLATION & PURIF Kidney Transplantation/*IMMUNOLOGY Longitudinal Studies Lymphocyte Culture Test, Mixed Lymphocyte Depletion Lymphocytes/*IMMUNOLOGY Male Middle Age Spleen/IMMUNOLOGY Support, Non-U.S. Gov't T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY Tissue Donors Transplantation, Homologous JOURNAL ARTICLE 950630
M9561159
AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.
Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.
