Immunogenicity and HIV-1 virus neutralization of MN recombinant glycoprotein 120/HIV-1 QS21 vaccine in baboons [published erratum appears in AIDS Res Hum Retroviruses 1995 May;11(5):661] NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Immunogenicity and HIV-1 virus neutralization of MN recombinant glycoprotein 120/HIV-1 QS21 vaccine in baboons [published erratum appears in AIDS Res Hum Retroviruses 1995 May;11(5):661]

AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S105-8. Unique Identifier : AIDSLINE MED/95169463
Powell MF; Cleland JL; Eastman DJ; Lim A; Murthy K; Newman MJ; Nunberg JH; Weissburg RP; Vennari JC; Wrin T; et al; Department of Pharmaceutical Research and Development, Genentech,; Inc., South San Francisco, California 94080.

Abstract: The effect of adjuvant and immunization schedule on the immunogenicity of HIV-1 envelope glycoprotein, MN rgp120, was optimized by using baboons. The novel adjuvant QS21 elicited earlier seroconversion than alum adjuvant, and the antibody titers to MN rgp120 for animals treated with QS21 were significantly greater than the titers obtained in animals treated with alum. The use of QS21 shifted the dose-response curve, resulting in less MN rgp120 required to achieve equivalent titers to those in the alum formulations. The in vitro virus neutralizing (VN) titers from animals treated with QS21 were 3- to 10-fold higher than with alum. The data presented herein point to the superiority of QS21 as adjuvant in primates for MN rgp120.
Keywords: AIDS Vaccines/ADMINISTRATION & DOSAGE/*IMMUNOLOGY Adjuvants, Immunologic/ADMINISTRATION & DOSAGE Alum Compounds/ADMINISTRATION & DOSAGE Animal Comparative Study HIV Antibodies/BIOSYNTHESIS HIV Envelope Protein gp120/ADMINISTRATION & DOSAGE/IMMUNOLOGY HIV Seropositivity/IMMUNOLOGY HIV-1/*IMMUNOLOGY In Vitro Neutralization Tests Papio Saponins/ADMINISTRATION & DOSAGE/IMMUNOLOGY Vaccines, Synthetic/ADMINISTRATION & DOSAGE/IMMUNOLOGY JOURNAL ARTICLEKWDaidsvaccines/administration&dosage/
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M9561153

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