Preparation for AIDS vaccine evaluation in Mombasa, Kenya: establishment of seronegative cohorts of commercial sex workers and trucking company employees.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Preparation for AIDS vaccine evaluation in Mombasa, Kenya: establishment of seronegative cohorts of commercial sex workers and trucking company employees.

AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S235-7. Unique Identifier : AIDSLINE MED/95169490
Martin HL Jr; Jackson DJ; Mandaliya K; Bwayo J; Rakwar JP; Nyange P; Moses S; Ndinya-Achola JO; Holmes K; Plummer F; et al; Department of Medicine, University of Washington, Seattle.

Abstract: In preparation for human immunodeficiency virus (HIV) prophylactic vaccine trials, prospective cohorts of HIV seronegative female commercial sex workers and male trucking company employees were established in Mombasa, Kenya, with the aims of defining HIV seroincidence and correlates of HIV seroconversion. Female and male cohorts were followed at 1- and 3-month intervals, respectively, with questionnaires, physical examinations, evaluation for sexually transmitted diseases, and HIV serologic testing. Between February and September, 1993, 1,277 women and 748 men were tested for antibodies to HIV-1. Seroprevalence was 55.4% among commercial sex workers and 17.7% among trucking company employees. Three hundred fifty-two HIV-seronegative women and 507 seronegative men were enrolled in the cohort studies. Annualized seroincidence rates of HIV infection were 16.4% (95% CI 8.8-27.0) among commercial sex workers and 6.6% (95% CI 2.5-13.8) among trucking company employees. These cohorts may be valuable resource for evaluating HIV vaccines and other potential preventive interventions.

Keywords: Adolescence Adult AIDS Vaccines/*PHARMACOLOGY Clinical Trials/METHODS Cohort Studies Female Human *HIV Seronegativity HIV Seropositivity/EPIDEMIOLOGY HIV Seroprevalence *HIV-1 Kenya/EPIDEMIOLOGY Male Middle Age Occupations Prospective Studies Prostitution Risk-Taking Sexually Transmitted Diseases/EPIDEMIOLOGY Support, U.S. Gov't, P.H.S. Transportation JOURNAL ARTICLE
950630
M9561126

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