1995

The:person with AIDS : psychosocial concerns. [videorecording]: Baltimore, Md. : The Press, c1994 1 videocassette (20 min.) : sd., col. ; 1/2 in (Nursing home infection control series) Unique Identifier : AIDSLINE AV/9503485; Smith PW; (Producer) The viewer will learn: specific guidelines which must be used when working with the person with AIDS in reference to blood-borne pathogens and other potentially infectious body fluids, universal precautions as applied to the nursing home environment, personal and environmental safeguards to prevent acciden
HIV and herpes : a challenging relationship. [videorecording]: Secaucus, N.J. : Network for Continuing Medical Education, 1995 1 videcassette (8 min.) : sd., col. ; 1/2 in (NCME telecourse ; no. 676) Unique Identifier : AIDSLINE AV/9506966; Berger TG; Dr. Berger reviews the diagnostic hallmarks for herpes simplex and herpes zoster in HIV patients, and discusses the management of patients, with particular attention to those patients who are resistant to acyclovir .
The:AIDS update. TAU 001 (Apr. 1985).: Medford, OR : Triversal Medical Research, [1985] 1 v Unique Identifier : AIDSLINE CAT/9503952
The:AIDS newsletter. TAU 002 (May 1986)-: Medford, OR : Triversal Medical Research, c1986- v Unique Identifier : AIDSLINE CAT/9503951
The:second sentence : the experience and needs of prisoners with HIV in H.M. prison system, England and Wales.: [London] : HM Prison Service, [1991] ii, 40, [16] p. : ill Unique Identifier : AIDSLINE CAT/9502629; Miller D; Curran L
The:hidden cost of AIDS : the challenge of HIV to development.: London ; Washington : Panos Institute, c1992 viii, 168 p. : ill (Panos dossier ; 6) Unique Identifier : AIDSLINE CAT/9442891
[Droit et S.I.D.A. : guide juridique.]: Paris : Librairie generale de droit et de jurisprudence, 1992 162 p Unique Identifier : AIDSLINE CAT/9408596
[Prevention SIDA.]: [Monaco] : Editions du Rocher, c1992 113 p Unique Identifier : AIDSLINE CAT/9408934; Mantion S
[S.I.D.A. et infection a V.I.H.] 2. ed. rev. et augm.: Paris : Masson, 1992 xii, 251 p. : ill (Abreges) Unique Identifier : AIDSLINE CAT/9408461; Cassuto J
[SIDA et politique : les premiers affrontements, 1981-1987.]: Paris : Editions L'Harmattan, c1992 206 p. : ill (Dossiers sciences humaines et sociales) Unique Identifier : AIDSLINE CAT/9409253; Favre P
Updates on human immuno-deficiency virus which causes AIDS disease and the Third World. 1st ed.: Hampton, Va. : United Brothers and Sisters Communications, 1993 x, 88 p. : ill Unique Identifier : AIDSLINE CAT/9438102; Akpan ME; Akpan JM
[--so ein Stuck Narrenfreiheit-- : der Berufsalltag von Aidsfachkraften in Selbstdeutungen : 4 Fallanalysen.]: Frankfurt am Main ; New York : Peter Lang, c1993 199 p (Europaische Hochschulschriften. Reihe 22, Soziologie ; Bd. 242) Unique Identifier : AIDSLINE CAT/9500007; Taube W
The:legal rights and obligations of HIV-infected health care workers.: San Francisco : American Association of Physicians for Human Rights, c1993 vi, 53 p Unique Identifier : AIDSLINE CAT/9502535; Gautier E
HIV-prevention in Switzerland : targets, strategies, interventions.: Bern : Federal Office of Public Health, National Aids Commission, 1993 viii, 248 p. : ill Unique Identifier : AIDSLINE CAT/9505972
[Petite encyclopedie des maladies sexuellement transmissibles : histoire et actualite.]: Paris : Editions Louis Pariente, c1993 383 p Unique Identifier : AIDSLINE CAT/9432697; Pariente L
[SIDA 1993 : l'infection par le virus de l'immunodeficience humaine en pratique medicale quotidienne.] 3. ed.: [Paris?] : AIDES, [1993] 201 p. : ill Unique Identifier : AIDSLINE CAT/9421209; Levasseur G
A:holistic protocol for the immune system : HIV/ARC/AIDS, candidiasis, chronic fatigue syndrome, herpes and other opportunistic infections. 5th ed., rev.: Joshua Tree, CA : Tree of Life Publications, [1993] x, 119 p. ; ill Unique Identifier : AIDSLINE CAT/9437355; Gregory SJ; Leonardo B
AIDS and STDs in Africa : bridging the gap between traditional healing and modern medicine.: Boulder : Westview Press ; Pietermaritzburg : University of Natal Press, 1994 xi, 276 p. : ill Unique Identifier : AIDSLINE CAT/9442933; Green EC
AIDS in Kenya : background, projections, impact, interventions.: [Nairobi : The Programme, 1994?] v, 38 p. : ill Unique Identifier : AIDSLINE CAT/9437412
Guidelines for HIV surveillance among tuberculosis patients.: Geneva : World Health Organization, [1994?] 11 p Unique Identifier : AIDSLINE CAT/9501411
Women and AIDS : agenda for action.: [Geneva? : World Health Organization, 1994] 11 p. : ill Unique Identifier : AIDSLINE CAT/9504948
Gardening in clay : reflections on AIDS.: Ithaca : Cornell University Press, 1994 x, 107 p Unique Identifier : AIDSLINE CAT/9443303; Valdiserri RO
Moral threats and dangerous desires : AIDS in the news media.: London ; Bristol, PA : Taylor & Francis, 1994 ix, 186 p. : ill (Social aspects of AIDS) Unique Identifier : AIDSLINE CAT/9434626; Lupton D
Proceedings.: Bleach Distribution Programs Washington, D.C. : National Academy Press, 1994 viii, 312 p. : ill Unique Identifier : AIDSLINE CAT/9501805
Abstracts of papers presented at the 1994 Meeting on Molecular Approaches to the Control of Infectious Diseases : October 5-October 9, 1994.: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory, [1994] xxxiv, 138 p Unique Identifier : AIDSLINE CAT/9442830; Brown F; Diseases
AIDS and behavior : an integrated approach : executive summary.: Washington, D.C. : National Academy Press, 1994 xviii, 38 p. : ill Unique Identifier : AIDSLINE CAT/9502467; Auerbach JD; Wypijewska C; Brodie HK; Mental Health Issues in AIDS Research
Outreach/risk reduction strategies for changing HIV-related risk behaviors among injection drug users : the National AIDS Demonstration Research (NADR) Project.: Rockville, Md. : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Institute on Drug Abuse ; Washington, DC : For sale by the U.S. G.P.O., Supt. of Docs., [1994] x, 77 p (NIH publication ; no. 94-3726) Unique Identifier : AIDSLINE CAT/9505040
Power and community : organizational and cultural responses to AIDS.: London ; Bristol, PA : Taylor & Francis, 1994 viii, 179 p (Social aspects of AIDS) Unique Identifier : AIDSLINE CAT/9443429; Altman D
AIDS and the demography of Africa.: Policy Analysis New York : United Nations, 1994 x, 72 p. : ill Unique Identifier : AIDSLINE CAT/9506321
Psychological medicine of HIV infection.: Oxford ; New York : Oxford University Press, 1995 xvi, 300 p. : ill (Oxford medical publications) Unique Identifier : AIDSLINE CAT/9505954; Catalan J; Burgess A; Klimes I
HIV : a practical approach. 1st ed.: Oxford ; New York : IRL Press at Oxford University Press, c1995 (Practical approach series ; v. 156-157) Unique Identifier : AIDSLINE CAT/9505955; Karn J
Tuberculosis and AIDS : the relationship between mycobacterium TB and the HIV type 1.: New York : Springer Pub. Co., c1995 xiii, 162 p. : ill Unique Identifier : AIDSLINE CAT/9506052; Scharer LL; McAdam JM
Cell activation and apoptosis in HIV infection : implications for pathogenesis and therapy.: New York : Plenum Press, c1995 xi, 245 p. : ill (Advances in experimental medicine and biology ; v. 374) Unique Identifier : AIDSLINE CAT/9506769; Andrieu J; Lu W; HIV Disease
Cutaneous immunosurveillance and its role in skin cancer (Meeting abstract).: Melanoma Res; 3:4 1993. Unique Identifier : AIDSLINE ICDB/95607226; Stingl G; Department of Dermatology, University of Vienna Medical School,; Vienna Austria; When, in the not-so-distant past, the skin was discussed in the context of immunological reactions, it was solely viewed as a target for immunological effector systems. Recent advances have radically changed this concept of an exclusively passive role of the skin in the immune response. In fact, there now exists ample
Kaposi's sarcoma: a reevaluation (Meeting abstract).: Melanoma Res; 3:6 1993. Unique Identifier : AIDSLINE ICDB/95607230; Orfanos CE; Dept. of Dermatology, University Medical Center Steglitz, The; Free University of Berlin, Berlin, Germany; Kaposi s sarcoma is a multicentric neoplasia of microvascular origin arising during developing immunodeficiency in HIV-infected individuals. Over 130 patients with HIV-associated Kaposi s sarcoma (98% male homosexuals, median age: 35 years) have been seen in our Berlin Department during 1982-1992. In some cases the tu
Phenotypic and functional characterization of tumor infiltrating gamma/delta T lymphocytes derived from a melanoma patient (Meeting abstract).: Melanoma Res; 3:22 1993. Unique Identifier : AIDSLINE ICDB/95607259; Jaggle CS; Ilsemann C; Kreysch HG; Nick S; Luckenbach GA; Pharmaceutical Research, E. Merck, W-61000 Darmstadt, Germany; Tumor infiltrating lymphocytes (TILs) are thought to play a significant role in immune surveillance of cancer, and their presence in high numbers has been associated with better prognosis of the patients. The majority of TILs express the alpha/beta T-cell receptor (TcR), however, in some tumors gamma/delta TcR express
Histogenesis of Kaposi's sarcoma: what is its origin? (Meeting abstract).: Melanoma Res; 3:32-3 1993. Unique Identifier : AIDSLINE ICDB/95607277; Orfanos CE; Wille S; Department of Dermatology, University Medical Center of Steglitz,; The Free University of Berlin, Berlin, Germany; Kaposi s sarcoma in HIV-infected individuals develops multicentrically, arising from cells of microvascular origin. Histologically, the tumor lesions express varying levels of differentiation, showing partly incomplete vascular lumina with endothelial cell (EC) proliferation, filled with erythrocytes, mostly surrounde
Cellular immunity in melanoma patients with organic metastases (Meeting abstract).: Melanoma Res; 3:47 1993. Unique Identifier : AIDSLINE ICDB/95607302; Wehner-Caroli J; Bogenschutz O; Rassner G; Fierlbeck G; Department of Dermatology, University of Tubingen, Germany; In patients with malignant melanoma stage IV (UICC 1979) peripheral mononuclear blood cells were investigated by flow cytometric analysis. We evaluated 30 patients in an advanced stage of malignant melanoma compared to a control group of 35 healthy adults. For statistic analysis the student T-test (significant level p
Mechanism of upregulation of IL-4 receptors by human immunodeficiency virus (HIV-1) tat gene (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A241 1995. Unique Identifier : AIDSLINE ICDB/95608021; Husain SR; Leland P; Puri RK; Laboratory of Molecular Tumor Biology, Division of Cell and Gene; Therapies, Center for Biologics Evaluation and Research, FDA,; Bethesda, MD 20892; The human immunodeficiency virus type 1 (HIV-1) regulatory gene, tat, encodes an early trans-activator protein (Tat) necessary for virus replication. We have recently reported that HIV-1 tat gene upregulated both protein and mRNA levels of interleukin 4 receptors (IL-4R) on a human B-lymphoblastoid cell line (Raji). I
A novel anti-angiogenic protein, apolipoprotein E3, inhibits angiogenesis by blocking the G1 to S transition of Kaposi's sarcoma-derived spindle cells (Meeting abstract).: Proc Annu Meet Am Assoc Cancer Res; 36:A198 1995. Unique Identifier : AIDSLINE ICDB/95607978; Wang W; Sethi A; Vogel T; Browning PJ; Vanderbilt Univ., Nashville, TN 37232; Acquired immunodeficiency syndrome (AIDS)-associated Kaposi s sarcoma (KS) and atherosclerosis are cytokine mediated diseases that share many common features. Both diseases are associated with a decrease in plasma high density lipoproteins (HDL) that contain an apolipoprotein termed apolipoprotein E3 (ApoE3). We demon
3rd international conference of the Mediterranean Society of Tumor Marker Oncology (MESTMO), October 26-29, 1994, Athens, Greece.: 3rd International Conference of the Mediterranean Society of Tumor Marker Oncology (MESTMO), October 26-29, 1994, Athens, Greece, 1994.. Unique Identifier : AIDSLINE ICDB/95614984; Anonymous; No affiliation given; The 3rd international conference of the Mediterranean Society of Tumor Marker Oncology, held October 26-29, 1994, in Athens, Greece , consisted of plenary lectures, symposia, and 10 sessions. The following plenary lectures were prese
[Health care of refugees (editorial)]: Duodecim. 1992;108(1):13-5. Unique Identifier : AIDSLINE MED/95196597; Kyronseppa H
[Treatment and prevention of HIV infection and related opportunistic infections]: Duodecim. 1992;108(5):507-15. Unique Identifier : AIDSLINE MED/95203150; Lumio J; TAYS, Tampere.
Clinical significance of in vitro donor-specific hyporesponsiveness in renal allograft recipients as demonstrated by the MLR.: Transpl Int. 1994;7(6):420-7. Unique Identifier : AIDSLINE MED/95169247; Ghobrial II; Morris AG; Booth LJ; Renal Unit, Walsgrave Hospital, Coventry, UK.; A longitudinal study was carried out on 19 recipients of cadaveric renal allografts, monitoring their anti-donor and anti-third party responses in the mixed lymphocyte reaction (MLR) at the time of transplantation and at 3, 6, and 12 months post-transplant. Two patterns of responses were identified: in the first (n =
2nd International Congress on Drug Therapy in HIV Infection. Glasgow, Scotland, 18-22 November 1994. Abstracts.: AIDS. 1994 Nov;8 Suppl 4:S1-57. Unique Identifier : AIDSLINE MED/95169306
Malignant lymphoproliferative diseases in HIV-seropositive patients. A study of 40 cases at a single institution in Spain.: Acta Oncol. 1995;34(1):75-82. Unique Identifier : AIDSLINE MED/95169417; Ribas A; Bellmunt J; Albanell J; Capdevila JA; Ocana I; Gallego OS; Maldonado J; Giralt J; Sole LA; Medical Oncology Section, Hospital General Vall d'Hebron,; Barcelona, Spain.; We identified 40 patients with malignant lymphoproliferative diseases (MLD) and HIV infection (seropositive) at a single Spanish university hospital. Thirty-two patients had non-Hodgkin s lymphoma (NHL), 6 primary central nervous system lymphoma (PCL) and 8 patients Hodgkin s disea
Antimicrobial factors and microbial contaminants in human milk: recent studies.: J Paediatr Child Health. 1994 Dec;30(6):470-5. Unique Identifier : AIDSLINE MED/95169434; May JT; Department of Microbiology, La Trobe University, Bundoora,; Victoria, Australia.; An overview of recent studies of antimicrobial factors and microbial contaminants found in human milk is presented. The incidence of gastrointestinal and respiratory infections in infants receiving human milk continues to be lower than in those not breast-fed due to the presence of specific antibody and possibly anti-
Emerging epidemiologic patterns of HIV in the United States.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S1. Unique Identifier : AIDSLINE MED/95169461; Holmberg SD
Advances in AIDS Vaccine Development: 6th Annual Meeting of the National Cooperative Vaccine Development Groups for AIDS. Alexandria, Virginia, October 30-November 4, 1993.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S1-325. Unique Identifier : AIDSLINE MED/95169462
Immunogenicity and HIV-1 virus neutralization of MN recombinant glycoprotein 120/HIV-1 QS21 vaccine in baboons [published erratum appears in AIDS Res Hum Retroviruses 1995 May;11(5):661]: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S105-8. Unique Identifier : AIDSLINE MED/95169463; Powell MF; Cleland JL; Eastman DJ; Lim A; Murthy K; Newman MJ; Nunberg JH; Weissburg RP; Vennari JC; Wrin T; et al; Department of Pharmaceutical Research and Development, Genentech,; Inc., South San Francisco, California 94080.; The effect of adjuvant and immunization schedule on the immunogenicity of HIV-1 envelope glycoprotein, MN rgp120, was optimized by using baboons. The novel adjuvant QS21 elicited earlier seroconversion than alum adjuvant, and the antibody titers to MN rgp120 for animals treated with QS21 were significantly greater tha
Mechanisms behind the immune response induced by immunostimulating complexes.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S109-14. Unique Identifier : AIDSLINE MED/95169464; Morein B; Villacres Eriksson M; Akerblom L; Ronnberg B; Lovgren K; Sjolander A; Section of Virology, National Veterinary Institute, Uppsala,; Sweden.
Mucosal immunity in the female genital tract: relevance to vaccination efforts against the human immunodeficiency virus.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S11-20. Unique Identifier : AIDSLINE MED/95169465; Mestecky J; Kutteh WH; Jackson S; Department of Microbiology and Medicine, University of Alabama at; Birmingham.; The development of vaccines that induce specific immune responses in the genital tract secretions would have far-reaching implications for the prevention of AIDS and other sexually transmitted diseases. Most of the currently studied vaccines utilize systemic routes of immunization that are of limited value for the pre
Vaccine protection and reduced virus load from heterologous macaque-propagated SIV challenge.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S117-21. Unique Identifier : AIDSLINE MED/95169466; Heeney JL; Holterman L; ten Haaft P; Dubbes R; Koornstra W; Teeuwsen V; Bourquin P; Norley S; Niphuis H; Laboratory of Viral Pathogenesis, Biomedical Primate Research; Center TNO, Rijswijk, The Netherlands.; The efficacy of vaccine protection afforded by live attenuated vaccines was tested by heterologous SIVtno8980 challenge following successful protection against homologous SIVmac32H challenge. Animals immunized with the attenuated SIVmacBK28 molecular clone were asymptomatic and virus isolation negative by quantitative
Effect of mutations in rev gene of SIVmac on virus replication.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S123-8. Unique Identifier : AIDSLINE MED/95169467; Aavik E; Hakkarainen K; Krohn KJ; Institute of Biomedical Sciences, University of Tampere, Finland.; The functional activity of SIVmac251 Rev was altered by introducing amino acid changes inside and chain termination mutations after the Rev response element-binding region (RBR) of the protein. The effects of specific mutations were evaluated by transfecting proviral DNAs into the HeLa cell line and into HeLa cells co
HIV-1 infection in pigtailed macaques.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S129-33. Unique Identifier : AIDSLINE MED/95169468; Gartner S; Liu Y; Lewis MG; Polonis V; Elkins WR; Zack PM; Miao J; Hunter EA; Greenhouse J; Eddy GA; Henry M. Jackson Foundation Research Laboratory, Rockville,; Maryland 20850.; Four pigtailed macaques were inoculated with autologous cells expressing low levels of human immunodeficiency virus type 1 (HIV-1). During the first 10 weeks, infectious virus was recovered from peripheral blood mononuclear cells (PBMCs) and lymph nodes from three of the animals. Subsequently, HIV-1 DNA was frequently
Safety profile of HIV vaccination: first 1000 volunteers of AIDS vaccine evaluation group. NIAID AIDS Vaccine Clinical Trials Network.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S139-40. Unique Identifier : AIDSLINE MED/95169469; Keefer MC; Belshe R; Graham B; McElrath J; Clements ML; Sposto R; Fast P; University of Rochester School of Medicine and Dentistry, NY.
Phase I/II trials of preventive HIV vaccine candidates. Dose and schedule: summary.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S141-3. Unique Identifier : AIDSLINE MED/95169470; Gorse GJ; Department of Internal Medicine, Saint Louis University Health; Sciences Center, Missouri 63110-0250.
Serological responses to candidate AIDS vaccines.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S145-8. Unique Identifier : AIDSLINE MED/95169471; Graham BS; Department of Medicine, Vanderbilt University School of Medicine,; Nashville, Tennessee 37232.
Preliminary results of V3 loop peptide-primary neutralizing domain conjugate phase 1 vaccine trail.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S149-53. Unique Identifier : AIDSLINE MED/95169472; Rubinstein A; Goldstein H; Pettoello-Mantovani M; Cryz SJ; Department of Pediatrics, Microbiology, and Immunology, Albert; Einstein College of Medicine, Bronx, New York 10461.
Conference on advances in AIDS vaccine development--1993. Report of Perinatal Intervention Working Group.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S161-4. Unique Identifier : AIDSLINE MED/95169473; McNamara JG; Rogers M; Goldenthal K; Jackson JB; Rossi P; Fenton T; Fast PE; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20852.
Conference on advances in AIDS vaccine development--1993. Summary: Mucosal Immunity Workshop.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S165-70. Unique Identifier : AIDSLINE MED/95169474; Mestecky J; Walker MC; Mathieson BJ; Walker BD; Department of Microbiology, University of Alabama at Birmingham; 35294.
Conference on advances in AIDS vaccine development--1993. Summary: correlates of HIV Immunity Working Group.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S171-6. Unique Identifier : AIDSLINE MED/95169475; Sheppard H; Bridges SH; Mathieson BJ; Walker MC; Weinhold K; California Department of Health Services, Berkeley 94704.
Conference on advances in AIDS vaccine development--1993. Summary: cytotoxic T-cell Immunity Workshop.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S177-9. Unique Identifier : AIDSLINE MED/95169476; Walker MC; Walker BD; Mestecky J; Mathieson BJ; Vaccine Research and Development Branch, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892-7640.
Towards a preventive HIV vaccine--lessons from history.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S181-5. Unique Identifier : AIDSLINE MED/95169477; Tramont EC; Medical Biotechnology Center, University of Maryland; Biotechnology Institute, Baltimore 20201.
Preparations for AIDS vaccine trials. Respecting concerns of international host countries.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S187-9. Unique Identifier : AIDSLINE MED/95169478; Katongole-Mbidde E; Uganda Cancer Institute, Kampala.
Preparations for HIV vaccine trials: moving from baseline studies to efficacy trials.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S191-3. Unique Identifier : AIDSLINE MED/95169479; Hoff R; DAIDS, NIAID, NIH, Bethesda, Maryland 20892-7620.; In summary, much has been accomplished in the past year, but much still remains to be done before we can embark on an efficacy trial. With the availability of a fully operational network, the NIAID has in place the resources and mechanisms to complete baseline feasibility studies and to conduct the future trials. As p
Overview: HIV vaccine feasibility studies.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S195-6. Unique Identifier : AIDSLINE MED/95169480; Sheon AR; Vaccine Trials and Epidemiology Branch, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892-7620.
Preparations for AIDS vaccine trials. Recruitment and retention of in- and out-of-treatment injection drug users.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S197-9. Unique Identifier : AIDSLINE MED/95169481; Woody GE; Metzger D; Mulvaney F; PENN/VA Center for Studies of Addiction, Philadelphia 19104.
Preparations for AIDS vaccine trials. Incident human immunodeficiency virus (HIV) infections in a cohort of injection drug users in Baltimore, Maryland.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S201-5. Unique Identifier : AIDSLINE MED/95169482; Nelson KE; Vlahov D; Galai N; Astemborski J; Solomon L; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, Maryland 21205.; In order to prepare for a possible trial of a preventive human immunodeficiency virus (HIV) vaccine in a population of injection drug users (IDUs) we followed a cohort to determine their HIV incidence, compliance with follow-up visits at 3-month intervals (i.e., quarterly) and their attitudes toward HIV vaccine trial
Preparations for AIDS vaccine trials. Retention, behavior change, and HIV-seroconversion among injecting drug users (IDUs) and sexual partners of IDUs.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S207-13. Unique Identifier : AIDSLINE MED/95169483; Marmor M; Titus S; Wolfe H; Krasinski K; Maslansky R; Simberkoff M; Beatrice S; Nichols S; Des Jarlais DC; Department of Environmental Medicine, New York University School; of Medicine, NY 10010.; The likelihood that subjects in human immunodeficiency virus (HIV) vaccine efficacy trials will alter their behavioral risks for HIV infection over time must be considered in evaluating the feasibility of such trials and in estimating the necessary sample sizes to be enrolled. Potential subjects for future vaccine eff
Development of a single-shot subunit vaccine for HIV-1.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S21-6. Unique Identifier : AIDSLINE MED/95169484; Cleland JL; Powell MF; Lim A; Barron L; Berman PW; Eastman DJ; Nunberg JH; Wrin T; Vennari JC; Department of Pharmaceutical Research and Development, Genentech,; Inc., South San Francisco, California 94080.; The successful development of an AIDS vaccine will require formulations that not only invoke the desired immunological response, but also are stable and easy to administer. A single shot MN rgp120 vaccine formulation comprised of MN rgp120 encapsulated in poly (lactic-coglycolic) acid (PLGA) microspheres was developed
Seroprevalence and seroincidence of HIV-1 in injection drug users using the VA system.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S215-7. Unique Identifier : AIDSLINE MED/95169485; Hartigan PM; Hamilton JD; Department of Veterans Affairs Medical Center, West Haven, CT; 06516.
Preparations for AIDS vaccine trials. Discussion on progress in domestic cohort development and evaluation.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S221. Unique Identifier : AIDSLINE MED/95169486
Preparations for AIDS vaccine evaluations. Progress in international cohort development and evaluation.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S223-5. Unique Identifier : AIDSLINE MED/95169487; Fischer RD; McNeil JG
Preparations for AIDS vaccine evaluations. AIDS International Training and Research Program.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S227-9. Unique Identifier : AIDSLINE MED/95169488; Bridbord K; Fogarty International Center, National Institutes of Health,; Bethesda, MD 20892-2220.
Feasibility and cohort development for HIV vaccine trials in Haiti.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S231-3. Unique Identifier : AIDSLINE MED/95169489; Deschamps MM; Johnson WD Jr; Pape JW; Groupe Haitien D'Etude du Sarcome de Kaposi et des Infections; Opportunistes (Gheskio), Port-au-Prince, Haiti.; Human immunodeficiency virus (HIV) infection is spreading rapidly in Haiti with HIV seroprevalence rates of 10% and 3% in urban and rural areas, respectively. Since 1985, heterosexual transmission has been the primary mode of acquisition of HIV. From 1981 to the present, the Cornell
Preparation for AIDS vaccine evaluation in Mombasa, Kenya: establishment of seronegative cohorts of commercial sex workers and trucking company employees.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S235-7. Unique Identifier : AIDSLINE MED/95169490; Martin HL Jr; Jackson DJ; Mandaliya K; Bwayo J; Rakwar JP; Nyange P; Moses S; Ndinya-Achola JO; Holmes K; Plummer F; et al; Department of Medicine, University of Washington, Seattle.; In preparation for human immunodeficiency virus (HIV) prophylactic vaccine trials, prospective cohorts of HIV seronegative female commercial sex workers and male trucking company employees were established in Mombasa, Kenya , with the aims of defining HIV seroincidence and correlates
Preparations for AIDS vaccine evaluations. Rate of new HIV infection in a cohort of women of childbearing age in Malawi.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S239-41. Unique Identifier : AIDSLINE MED/95169491; Miotti P; Canner J; Chiphangwi J; Liomba G; Saah A; Dallabetta G; Johns Hopkins University, Baltimore, Maryland 21205.
Preparatory studies for possible HIV vaccine trials in northern Thailand.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S243-6. Unique Identifier : AIDSLINE MED/95169492; Nelson KE; Beyrer C; Natpratan C; Eiumtrakul S; Celentano DD; Khamboonruang C; Department of Epidemiology, Johns Hopkins University, School of; Hygiene and Public Health, Baltimore, Maryland.; We studied several populations of human immunodeficiency virus (HIV)-seronegative individuals from northern Thailand who were believed to be at relatively high risk of HIV infection in order to assess their potential suitability for inclusion in a preventive HIV vaccine trial. In
HIV preventive vaccine efficacy trials in the United States: an overview of target communities' concerns.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S255-6. Unique Identifier : AIDSLINE MED/95169493; Hodel D; Gay Men's Health Crisis, New York, New York.
Participation of homosexual/bisexual men in preventive HIV vaccine trials: baseline attitudes and concerns and predicted behaviors during trials.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S257-60. Unique Identifier : AIDSLINE MED/95169494; Douglas JM Jr; Judson FN; Parks JP; Buchbinder S; McKirnan D; Denver Department of Public Health, CO 80204.
The decision to enroll in HIV vaccine efficacy trials: concerns elicited from gay men at increased risk for HIV infection.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S261-4. Unique Identifier : AIDSLINE MED/95169495; MacQueen KM; Buchbinder S; Douglas JM; Judson FN; McKirnan DJ; Bartholow B; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, GA 30333.
Interest in HIV vaccines among injection drug users in Baltimore, Maryland.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S265-8. Unique Identifier : AIDSLINE MED/95169496; Vlahov D; Astemborski J; Solomon L; Galai N; Basarab L; Nelson KE; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, Maryland 21205.; To gauge interest about participation in human immunodeficiency virus type 1 (HIV vaccines, we interviewed 375 HIV-seronegative injecting drug users who are participants in an ongoing longitudinal study of HIV infection. Nearly all (93%) responded that they thought it likely that an HIV vaccine would become available,
Immunization with virion-derived glycoprotein 130 from HIV-2 or SIV protects macaques against challenge virus grown in human or simian cells or prepared ex vivo.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S27-32. Unique Identifier : AIDSLINE MED/95169497; Stahl-Hennig C; Coulibaly C; Petry H; Voss G; Dittmer U; Bodemer W; Makoschey B; Jurkiewicz E; Luke W; Hunsmann G; Deutsches Primatenzentrum, Abteilung Virologie und Immunologie,; Goettingen, Germany.; We have compared in the macaque model the efficacy of the virion-derived glycoprotein of HIV-2ben (HIV-2 gp130) with that of SIVmac251/32H (SIV gp130). The latter vaccination trial was in part combined with vaccinia virus (VV) priming. Both antigen preparations induced a strong humoral, but a weak cellular, immune res
Behavioral studies relevant to vaccine trial preparation: an introduction.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S273-6. Unique Identifier : AIDSLINE MED/95169498; Turner CF; Sheon AR; Program in Health and Behavior Measurement, Research Triangle; Institute, Rockville, Maryland 20852.; Preparations for large-scale trials to test the efficacy of candidate HIV vaccines can benefit in several crucial ways from a targeted program of behavioral and social research. Randomized field experiments testing alternative procedures for the recruitment and retention of subjects can help identify research procedur
Behavioral research contributions to planning and conducting HIV vaccine efficacy studies.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S277-80. Unique Identifier : AIDSLINE MED/95169499; Temoshok LR; Henry M. Jackson Foundation for the Advancement of Military; Medicine, Rockville, Maryland.
Preparations for AIDS vaccine trials. An automated version of the Risk Assessment Battery (RAB): enhancing the assessment of risk behaviors.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S281-3. Unique Identifier : AIDSLINE MED/95169500; Navaline HA; Snider EC; Petro CJ; Tobin D; Metzger D; Alterman AI; Woody GE; PENN/VA Center for Studies of Addiction, Philadelphia 19104.; Our primary objective during this pilot work has been to determine if the computerized RAB can be used in place of the paper-and-pencil version with an IDU population. As stated, reliability estimates in the form of correlations of risk scores between the two versions ranged from .82 to .94, and percentages of exact a
Preparations for AIDS vaccine trials. Developing brief valid screening instruments for HIV-related sexual risk behavior among gay and bisexual men.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S285-8. Unique Identifier : AIDSLINE MED/95169501; McKirnan DJ; Doetsch J; Vanable P; Buchbinder S; Douglas JM; Judson F; University of Illinois at Chicago, Department of Psychology, IL.; Enrolling and tracking cohorts for HIV vaccine efficacy trials requires that participants disclose behaviors that place them at risk for exposure to HIV. Brief screening procedures have been suggested for this purpose. In a previous study gay and bisexual men in three U.S. cities reported unprotected anal intercourse
Global HIV vaccines: economic considerations.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S293-4. Unique Identifier : AIDSLINE MED/95169502; Petricciani JC; Genetics Institute, Cambridge, Massachusetts 02140.
Preparations for HIV vaccine efficacy trials. Vaccine selection guidelines. National Institute of Allergy and Infectious Diseases, National Institutes of Health.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S295-6. Unique Identifier : AIDSLINE MED/95169503; Barker LF
Vaccine liability and participant compensation incentives in HIV vaccine trials.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S297-300. Unique Identifier : AIDSLINE MED/95169504; Stein RE; Blicker, Futterman, & Stein, Washington, D.C. 20006.
HIV vaccines for injection drug users in the context of a comprehensive prevention agenda.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S3-6. Unique Identifier : AIDSLINE MED/95169505; Vlahov D; Johns Hopkins School of Hygiene and Public Health, Baltimore,; Maryland.; Human immunodeficiency virus (HIV) infection among injecting drug users remains a major health problem. Traditional approaches to prevent parenteral transmission of HIV infection in this population include abstinence facilitated through treatment for drug abuse, HIV testing with education and counseling, disinfection
Preparations for AIDS vaccine trials. Intellectual property issues related to AIDS vaccine development from a federal laboratory perspective.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S301. Unique Identifier : AIDSLINE MED/95169506; Mays TD; Maurey K; National Cancer Institute, National Institutes of Health,; Bethesda, Maryland 20892-3100.
The role of prevention research in HIV vaccine trials.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S303-5. Unique Identifier : AIDSLINE MED/95169507; Vermund SH; UAB School of Public Health, 35294-0008.; The National Institute of Allergy and Infectious Diseases has prepared for HIV vaccine efficacy trials with the hope of having a product which is deemed worthy of testing. This has entailed development of new field research infrastructure and training, in collaboration with many partners. Notably, experts in observati
Panel discussion on vaccine development to meet U.S. and international needs. Perspectives on national and global HIV vaccine development: potential ways to reduce impediments for biopharmaceutical product development.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S307-8. Unique Identifier : AIDSLINE MED/95169508; Obijeski J; Department of Product Development, Genentech, Inc., South San; Francisco, California 94080.
Panel discussion on vaccine development to meet U.S. and international needs. When manufacturers are unwilling to accept the risks or invest the capital: vaccine production by the Salk Institute to specifications of the U.S. Army.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S309. Unique Identifier : AIDSLINE MED/95169509; French GR; Salk Institute Government Services Division, Swiftwater,; Pennsylvania 18370.
Panel discussion on vaccine development to meet U.S. and international needs. Strategies for reducing the disincentives to HIV vaccine development: description of a successful public-private sector international collaboration.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S311-3. Unique Identifier : AIDSLINE MED/95169510; Bronnenkant L; Finishing Enterprises, N. Tonawanda, New York 14120.
Recent advances in AIDS vaccine research and development.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S317-23. Unique Identifier : AIDSLINE MED/95169511; Johnston MI; Noe JS; Killen JY; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Bethesda, Maryland; 20892.; There is an urgent need for a prophylactic vaccine to protect individuals from AIDS and to help abate the growing epidemic. In October 1993, the Conference on Advances in AIDS Vaccine Development reviewed the state-of-the-art in vaccine research and confirmed both the progress that has been made and the challenges tha
DNA inoculation induces protective in vivo immune responses against cellular challenge with HIV-1 antigen-expressing cells.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S35-41. Unique Identifier : AIDSLINE MED/95169512; Wang B; Merva M; Dang K; Ugen KE; Boyer J; Williams WV; Weiner DB; Department of Medicine, University of Pennsylvania School of; Medicine, Philadelphia 19104.; Direct DNA inoculation induces immune responses through the delivery of nonreplicating transcription units that drive the synthesis of specific foreign proteins within the inoculated host. These proteins are processed within host cells and through association with relevant MHC antigens that can become the subject of i
Accell particle-mediated DNA immunization elicits humoral, cytotoxic, and protective immune responses.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S43-5. Unique Identifier : AIDSLINE MED/95169513; Haynes JR; Fuller DH; Eisenbraun MD; Ford MJ; Pertmer TM; Agracetus, Inc., Middleton, Wisconsin 53562.; Accell particle-mediated gene delivery technology was employed for the intracellular delivery of antigen-encoding expression vectors in epidermal tissues in laboratory animals. Delivery of plasmid DNA-coated gold microparticles using the Accell gene delivery system resulted in de novo antigen expression in epidermal c
Libraries of human rhinovirus-based HIV vaccines generated using random systematic mutagenesis.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S47-52. Unique Identifier : AIDSLINE MED/95169514; Resnick DA; Smith AD; Zhang A; Geisler SC; Arnold E; Arnold GF; Center for Advanced Biotechnology and Medicine, Rutgers; University, Piscataway, New Jersey 08854.; Human rhinovirus (HRV), an immunogenic and relatively nonpathogenic virus, has been engineered to display HIV-1 immunogens with the intent of developing a vaccine against AIDS. HIV immunogens from the V3 loop have been placed into the neutralizing immunogenic (NIm) sites on the surface of HRV14 naturally recognized by
Dicistronic polioviruses as expression vectors for foreign genes.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S57-60. Unique Identifier : AIDSLINE MED/95169515; Alexander L; Lu HH; Gromeier M; Wimmer E; Department of Microbiology, School of Medicine, SUNY at Stony; Brook 11794.; We have made use of certain novel genetic elements of picornaviruses termed internal ribosomal entry sites (IRES) to construct a viral RNA with the following genetic order: PV 5 NTR-EMCV IRES-PV ORF-3 NTR (PV, poliovirus; NTR, nontranslated region; EMCV, encephalomyocarditis virus; ORF, open reading frame). Transfec
New approaches for mucosal vaccines for AIDS: encapsidation and serial passages of poliovirus replicons that express HIV-1 proteins on infection.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S61-6. Unique Identifier : AIDSLINE MED/95169516; Morrow CD; Porter DC; Ansardi DC; Moldoveanu Z; Fultz PN; Department of Microbiology, University of Alamaba at Birmingham; 35294.; It is apparent that a safe and effective HIV vaccine is an important component in the development of rational approaches for the control and prevention of HIV transmission. Given the fact that the virus most often encounters a mucosal surface during sexual transmission, a vaccine designed to stimulate both the systemi
Evaluation of cytotoxic T cell responses to candidate HIV-1 vaccines in HIV-1-uninfected individuals.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S69-72. Unique Identifier : AIDSLINE MED/95169517; McElrath MJ; Corey L; Greenberg PD; Department of Medicine, University of Washington School of; Medicine, Seattle 98195.; The ability to induce a strong, HIV-1-specific CD8+ CTL response is assumed to be an important component of a protective HIV-1 vaccine. Identification of CTL responses in seronegative vaccines requires in vitro stimulation of CTL precursors with cells that have processed HIV-1 gene products via the endogenous intracel
HIV vaccines in the context of a broader prevention agenda--views from urban U.S. projects: Washington, D.C. studies among adolescents.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S7. Unique Identifier : AIDSLINE MED/95169518; D'Angelo LJ; Children's National Medical Center, George Washington University,; Washington, D.C. 20010-2970.
HIV-1 env-specific cellular cytotoxicity in HIV-1-seropositive mothers and their infants.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S79-82. Unique Identifier : AIDSLINE MED/95169521; Skowron G; Brown University School of Medicine, Providence, RI.
Cytotoxic T lymphocyte activity in children infected with HIV.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S83-8. Unique Identifier : AIDSLINE MED/95169522; Froebel KS; Aldhous MC; Mok JY; Hayley J; Arnott M; Peutherer JF; Department of Medicine, University of Edinburgh, United Kingdom.; Of the Edinburgh cohort of approximately 130 children born to HIV-infected women, 9 are infected and alive. This article describes results from the first 18 months of a natural history study of seven of these, and two adopted children, studying the CD8 T cell-mediated cytotoxicity against HIV proteins (Gag, Tat, Pol,
Suitability of Trinidad/Tobago as a potential site for phase III efficacy studies of HIV-1 vaccines.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S9. Unique Identifier : AIDSLINE MED/95169523; Paul R; Cleghorn F; Jack N; Edwards J; Mahabir B; Murphy J; Blattner W; Bartholomew C; Ministry of Health, Roundabout Plaza, Barataria, Trinidad.
Mechanisms of action of nonionic block copolymer adjuvants.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S95-8. Unique Identifier : AIDSLINE MED/95169525; Hunter RL; McNicholl J; Lal AA; Department of Pathology and Laboratory Medicine, Emory; University, Atlanta, Georgia 30322.; Nonionic block copolymer adjuvants typically induce high-titer, long-lasting antibody responses, cell-mediated immunity, CTLs, and modulate the isotype and specificity of antibody. Their primary activity is modulation of hydrophobic adhesive interactions. The copolymers adhere to lipids, promote retention of protein a
Lipid matrix-based subunit vaccines: a structure-function approach to oral and parenteral immunization.: AIDS Res Hum Retroviruses. 1994;10 Suppl 2:S99-103. Unique Identifier : AIDSLINE MED/95169526; Gould-Fogerite S; Edghill-Smith Y; Kheiri M; Wang Z; Das K; Feketeova E; Canki M; Mannino RJ; Department of Laboratory Medicine and Pathology, UMDNJ-New Jersey; Medical School, Newark 07103.; Immunization is today the most effective defense mechanism against microbial infections. Although highly effective vaccines are currently available for a number of infectious diseases, vaccine formulations can still be improved in a number of important areas. The ability to induce antigen-specific humoral and cell-med
1994 Annual meeting of the Laboratory of Tumor Cell Biology. Rockville, Maryland, September 25-October 1, 1994. Abstracts.: AIDS Res Hum Retroviruses. 1994 Sep;10 Suppl 3:S63-170. Unique Identifier : AIDSLINE MED/95169527
The role of cytokines in toxoplasmosis.: Biotherapy. 1994;7(3-4):237-47. Unique Identifier : AIDSLINE MED/95169538; Hunter CA; Subauste CS; Remington JS; Department of Medicine, Stanford University School of Medicine,; California.; Infection with Toxoplasma gondii is normally asymptomatic, but as a consequence of the AIDS epidemic the incidence of symptomatic disease and especially toxoplasmic encephalitis (TE) has grown in frequency. The high frequency of adverse reactions to conventional therapeutic regimens for toxoplasmosis highlight the nee
Sexual homicide with HIV in a Florida dental office?: J Clin Pediatr Dent. 1994 Fall;19(1):61-4. Unique Identifier : AIDSLINE MED/95169611; Horowitz LG; Tetrahedron, Inc., Rockport, MA.
Transgenic mice expressing constitutive levels of IL-2 in islet beta cells develop diabetes.: Int Immunol. 1994 Nov;6(11):1629-37. Unique Identifier : AIDSLINE MED/95169642; Elliott EA; Flavell RA; Howard Hughes Medical Institute, Yale University School of; Medicine, New Haven, CT 06510.; IL-2 plays an important role in the clonal expansion of T cells during an immune response and it has been implicated in autoimmune disease. To examine the role of IL-2 in the regulation of peripheral tolerance we produced transgenic mice in which the expression of muri
CD4+ T cell associated cytokine gene expression during experimental infection with Listeria monocytogenes: the mRNA phenotype of granuloma formation.: Int Immunol. 1994 Nov;6(11):1727-37. Unique Identifier : AIDSLINE MED/95169652; Ehlers S; Mielke ME; Hahn H; Institut fur Medizinische Mikrobiologie und; Infektionsimmunologie, Freie Universitat Berlin, Germany.; In murine listeriosis, elimination of bacteria and immunity to re-infection critically depend on Thy-1+CD4- cells, while cell-mediated inflammatory phenomena like delayed-type hypersensitivity and granuloma formation are mediated by CD4+ T cells. In an attempt to correlate T cell phenotype and function with a particul
Human immune response to HIV-1-Nef. I. CD45RO- T lymphocytes of non-infected donors contain cytotoxic T lymphocyte precursors at high frequency.: Int Immunol. 1994 Nov;6(11):1739-49. Unique Identifier : AIDSLINE MED/95169653; Lucchiari M; Niedermann G; Leipner C; Meyerhans A; Eichmann K; Maier B; Max-Planck-Institut fur Immunbiologie, Freiburg, Germany.; The immune response of peripheral blood lymphocytes (PBL) of non-exposed human individuals to the Nef protein of HIV-1 was studied. Nef is a regulatory protein of HIV which is immediately expressed after infection and which seems to be important in the pathogenicity of HIV. Nef may therefore serve as a potential targe
Characterization of monoclonal antibodies against sporadic bovine leukosis cell lines.: J Vet Med Sci. 1994 Oct;56(5):827-33. Unique Identifier : AIDSLINE MED/95169773; Shinagawa T; Ishiguro N; Horiuchi M; Shinagawa M; Matsui T; Department of Veterinary Public Health, Obihiro University of; Agriculture and Veterinary Medicine, Hokkaido, Japan.; We report here distributions of antigens expressed on sporadic bovine leukosis (SBL) cells by a total of 38 monoclonal antibodies (mAbs) directed against three different types of SBL-cell lines, BLT2 (thymic type), BTL-PC3 (calf type) and BLS1 (skin type). Most mAbs had high reactivities with some bovine lymphoma cell
Comparative functional analysis of the various lentivirus long terminal repeats in human colon carcinoma cell line (SW480 cells) and feline renal cell line (CRFK cells).: J Vet Med Sci. 1994 Oct;56(5):895-9. Unique Identifier : AIDSLINE MED/95169785; Miyazawa T; Kawaguchi Y; Kohmoto M; Tomonaga K; Mikami T; Department of Veterinary Microbiology, Faculty of Agriculture,; University of Tokyo, Japan.; Basal promoter activities of various lentiviral long terminal repeats (LTRs) in a human colon carcinoma cell line (SW480 cells) and a feline renal cell line (CRFK cells) were examined by the chloramphenicol acetyltransferase (CAT) assay using the LTR-CAT reporter plasmids. In SW480 cells, the basal promoter activities
[Thrombotic thrombopenic purpura and HIV infection. Apropos of a case]: An Med Interna. 1994 Oct;11(10):493-5. Unique Identifier : AIDSLINE MED/95169859; Campayo Ibanez A; Perello Roso A; Lacruz Rodrigo J; Valls Ferrer JM; de la Rubia Comos J; Lopez Chuelia F; Unidad de Enfermedades Infecciosas (Servicio de Medicina; Interna), Hospital Universitario, La Fe, Valencia.; In the past years, more than thirty cases of thrombotic thrombocytopenic purpura (TTP) had been described associated to infection by the human immunodeficiency virus. Some authors have suggested the presence of a causal relationship between both entities, although the common nexus is still unknown. It usually has a fu
The next wave [editorial]: J Assoc Nurses AIDS Care. 1994 Nov-Dec;5(6):17. Unique Identifier : AIDSLINE MED/95170021; Kalinoski J
Management of suicidal patients with HIV disease.: J Assoc Nurses AIDS Care. 1994 Nov-Dec;5(6):19-29. Unique Identifier : AIDSLINE MED/95170022; Valente SM; Saunders JM; University of Southern California, Los Angeles.; Suicidal acts among people with HIV disease exceed those among the general population. Stress from the HIV diagnosis, treatment, and medications can lead to depression, which increases suicide risk. High quality care of depressed persons depends on sound scientific knowledge of evaluation of suicide. Incidence, epidem
A comparison of calculated energy requirements to measured resting energy expenditure in HIV-1-infected subjects.: J Assoc Nurses AIDS Care. 1994 Nov-Dec;5(6):30-4. Unique Identifier : AIDSLINE MED/95170023; Anderson R; Grady C; Ropka M; National Institute of Nursing Research, National Institutes of; Health, Bethesda, MD.; Twenty HIV-infected outpatients participating in clinical drug trials of the National Institute of Allergy and Infectious Diseases (NIAID) and enrolled in the collaborative National Institute of Nursing Research (NINR) nutrition study underwent indirect calorimetry measurements. Energy requirements for these subjects
Comorbidities of HIV-1/AIDS in adults.: J Assoc Nurses AIDS Care. 1994 Nov-Dec;5(6):35-44. Unique Identifier : AIDSLINE MED/95170024; Ungvarski PJ; Visiting Nurse Service of New York, NY.; The comorbid diagnoses associated with illness due to human immunodeficiency virus type 1 (HIV-1) are cumulative, multiple, and varied. These diagnoses start with primary infection, then progress to symptomatic illness and finally to AIDS-indicator diseases. The author reviews this progression and additional variables
A Kenyan experience.: Beginnings. 1994 Nov-Dec;14(10):11. Unique Identifier : AIDSLINE MED/95170211; Manahan D
A 'cycle of care': a model of community and hospital HIV/AIDS services.: Br J Nurs. 1994 Dec 8-1995 Jan 11;3(22):1198-9, 1201-4. Unique Identifier : AIDSLINE MED/95170278; Lempp H; deBoard L; Brown J
[Vertical transmission of the human T-cell leukemia virus in an endemic area. An epidemiological study in children from 0 to 5 years in Gabon]: Bull Soc Pathol Exot. 1994;87(4):217-21. Unique Identifier : AIDSLINE MED/95170296; Berteau PF; Martin-Prevel Y; Bedjabaga I; Laboratoire de Retrovirologie, Centre International de; Recherches Medicales de France ville (CIRMF), Gabon.; A seroepidemiological survey was conducted in a representative population of children aged 0-5 in Gabon . Breast-feeding appears to an important mode of HTLV vertical transmission. Owing to other epidemiological data in population of gabonese adults allow us to think that breast-feed
Unlinked anonymous HIV screening programme in England and Wales [editorial; comment]: BMJ. 1995 Jan 28;310(6974):206-7. Unique Identifier : AIDSLINE MED/95170395; Banatvala JE
HIV infection concentrated in London [news] [see comments]: BMJ. 1995 Jan 28;310(6974):213. Unique Identifier : AIDSLINE MED/95170402; Delamothe T
Imprisonment, injecting drug use, and bloodborne viruses [editorial] [see comments]: BMJ. 1995 Feb 4;310(6975):275-6. Unique Identifier : AIDSLINE MED/95170456; Gill ON; Noone A; Heptonstall J
Spread of bloodborne viruses among Australian prison entrants.: BMJ. 1995 Feb 4;310(6975):285-8. Unique Identifier : AIDSLINE MED/95170459; Crofts N; Stewart T; Hearne P; Ping XY; Breshkin AM; Locarnini SA; Epidemiology and International Health Unit, Macfarlane Burnet; Centre of Medical Research, Fairfield, Victoria, Australia.; OBJECTIVES--To assess spread of bloodborne viruses among prison entrants in Victoria, Australia . DESIGN--Voluntary confidential testing of all prison entrants for markers of exposure to bloodborne viruses with collection of minimal data on demography and risk factors over 12 mon
Outbreak of HIV infection in a Scottish prison [see comments]: BMJ. 1995 Feb 4;310(6975):289-92. Unique Identifier : AIDSLINE MED/95170460; Taylor A; Goldberg D; Emslie J; Wrench J; Gruer L; Cameron S; Black J; Davis B; McGregor J; Follett E; et al; Scottish Centre for Infection and Environmental Health, Ruchill; Hospital, Glasgow.; OBJECTIVE--To investigate the possible spread of HIV infection and its route of transmission among prison inmates. DESIGN--In response to an outbreak of acute clinical hepatitis B and two seroconversions to HIV infection, counselling and testing for HIV were offered to all inmates over a two week period in July 1993.
Drug injection and HIV prevalence in inmates of Glenochil prison [see comments]: BMJ. 1995 Feb 4;310(6975):293-6. Unique Identifier : AIDSLINE MED/95170461; Gore SM; Bird AG; Burns SM; Goldberg DJ; Ross AJ; Macgregor J; MRC Biostatistics Unit, Institute of Public Health, Cambridge.; OBJECTIVE--To determine prevalence of HIV infection and drug injecting behaviour among inmates of Glenochil Prison on a specified date a year after an outbreak of hepatitis B and HIV infection. DESIGN--Cross sectional: voluntary, anonymous HIV salivary antibody surveillance and linked self completion questionnaire on
Rethinking sexual health clinics [editorial] [see comments]: BMJ. 1995 Feb 11;310(6976):342-3. Unique Identifier : AIDSLINE MED/95170499; Stedman Y; Elstein M
Clinical pharmacology and therapeutics.: BMJ. 1995 Feb 11;310(6976):377-80. Unique Identifier : AIDSLINE MED/95170516; Breckenridge A; Department of Pharmacology and Therapeutics, University of; Liverpool.
Transmission of tuberculosis in patients with HIV infection [letter; comment]: BMJ. 1995 Feb 11;310(6976):401. Unique Identifier : AIDSLINE MED/95170538; Miller RF; Kent RJ; Uttley AH; Stoker NG; Pozniak AL
Potential development of community oriented HIV outreach among drug injectors in the UK.: Addiction. 1994 Dec;89(12):1601-11. Unique Identifier : AIDSLINE MED/95170568; Stimson GV; Eaton G; Rhodes T; Power R; Department of Psychiatry, Charing Cross and Westminster Medical; School, London, UK.; Given the current epidemiological and behavioural risk profile of HIV infection among injecting drug users in the UK, the main strategic task continues to be to develop interventions to prevent the spread of HIV infection. Outreach to drug injectors is an important part of the wider UK HIV prevention strategy. This pa
The use of benzodiazepines among regular amphetamine users.: Addiction. 1994 Dec;89(12):1683-90. Unique Identifier : AIDSLINE MED/95170576; Darke S; Ross J; Cohen J; National Drug and Alcohol Research Centre, University of New; South Wales, Australia.; The relationship between benzodiazepine and regular amphetamine use was examined in a sample of 301 regular amphetamine users. Benzodiazepine use was widespread, with 37% of subjects having used them in the month preceding interview, and 55% in the preceding 6 months. Injectors of amphetamines were more likely to have
The effects of HIV infection on the development of methadone maintenance treatment in Spain [news]: Addiction. 1994 Dec;89(12):1707-8. Unique Identifier : AIDSLINE MED/95170581; Torrens M; Cami J
Treatment of endogenous uveitis with anti-CD4 monoclonal antibody: first report.: Ger J Ophthalmol. 1994 Nov;3(6):409-13. Unique Identifier : AIDSLINE MED/95170585; Thurau SR; Wildner G; Reiter C; Riethmuller G; Lund OE; University Eye Hospital, Section of Immunology, Munich, Germany.; A patient with endogenous uveitis was treated with a chimeric monoclonal anti-CD4 antibody. This patient with long-standing therapy-refractive uveitis did not benefit immediately from antibody infusions, although the frequency of uveitis relapses was sharply reduced after this therapy. After treatment with the monoclo
Ocular microangiopathic syndrome in patients with acquired immunodeficiency syndrome and its relationship to alterations in cell adhesion and in blood flow.: Ger J Ophthalmol. 1994 Nov;3(6):414-21. Unique Identifier : AIDSLINE MED/95170586; Geier SA; Klauss V; Goebel FD; Forschungsstelle fur Experimentelle Ophthalmologie und; Augenklinik, Universitat Tubingen, Germany.; Ocular microangiopathic syndrome is the most frequent ophthalmic finding in patients with acquired immunodeficiency syndrome (AIDS). Ocular microvascular changes, including cotton-wool spots, are closely associated with neuroretinal and cognitive deficits in patients infected with the human immunodeficiency virus type
Human herpesvirus 6 and pneumonia.: Leuk Lymphoma. 1994 Oct;15(3-4):235-41. Unique Identifier : AIDSLINE MED/95170596; Cone RW; Huang ML; Hackman RC; Department of Laboratory Medicine, University of Washington,; Seattle.; Studies of lung tissues and bronchoalveolar lavage specimens from patients with pneumonia have led some investigators to propose that human herpesvirus 6 (HHV-6) can cause pneumonia. As the etiologic role of HHV-6 in pneumonia remains poorly defined, cases of pneumonia that are associated with pulmonary HHV-6 infectio
Clinicopathological features of adult T-cell leukemia with CD30 antigen expression.: Leuk Lymphoma. 1994 Oct;15(3-4):303-10. Unique Identifier : AIDSLINE MED/95170605; Ohtsuka E; Kikuchi H; Nasu M; Takita-Sonoda Y; Fujii H; Yokoyama S; Second Department of Internal Medicine, Oita Medical University,; Japan.; Recently, several cases of adult T-cell leukemia (ATL) with CD30 antigen have been reported, but its clinical significance remains unknown. Accordingly, we studied CD30 antigen expression in ATL cases and documented the clinicopathological characteristics of these cases. Immunohistochemical and clinical characteristic
[Selected topics of immunology in tuberculosis (editorial)]: Pneumonol Alergol Pol. 1994;62(9-10):439-43. Unique Identifier : AIDSLINE MED/95170640; Demkow U
The role of CD8+ T cells in the pathogenesis of atopic asthma.: Rom J Intern Med. 1994 Jul-Sep;32(3):173-84. Unique Identifier : AIDSLINE MED/95170662; Stanciu L; Institute of Hygiene and Public Health, Cluj-Napoca, Romania.; The role of the CD8+ T cells, a specialized subset of T cells, in the pathogenesis of atopic asthmatics is presented on the basis of the latest data. Thus the authors discuss the regulatory role of the CD8+ T cells in the synthesis of IgE, the environmental factors which activate preferentially the CD8+ cells as well
An autopsy case of acquired immune deficiency syndrome (AIDS) with preceding aplastic anemia.: Pathol Int. 1994 Dec;44(12):850-6. Unique Identifier : AIDSLINE MED/95170923; Nagasaki M; Harada T; Torii I; Nakano A; Furuya H; Tanaka J; Hirai K; Morikawa S; Department of Pathology, Shimane Medical University, Izumo,; Japan.; A case of acquired immunodeficiency syndrome (AIDS) with preceding aplastic anemia is reported. The patient was a 36 year old female who had been diagnosed as having aplastic anemia 10 years before and thereafter had received multiple transfusions. Human immunodeficiency virus (HIV)-seropositivity was revealed 10 mont
Mechanisms of sexual transmission of HIV: does HIV infect intact epithelia?: Trends Microbiol. 1994 Nov;2(11):454-8. Unique Identifier : AIDSLINE MED/95171069; Phillips DM; Zacharopoulos VR; Tan X; Pearce-Pratt R; Population Council, New York, NY 10021.; The prevailing view of sexual transmission of HIV has been that the virus enters the body through lesions in the epithelium of the genital tract. We propose that transmission of HIV can occur via the infection of intact epithelial cells, and that it is mediated by HIV-infected mononuclear cells in genital-tract secret
The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.: Structure. 1994 Oct 15;2(10):915-24. Unique Identifier : AIDSLINE MED/95171109; Champness JN; Achari A; Ballantine SP; Bryant PK; Delves CJ; Stammers DK; Physical Sciences Department, Wellcome Research Laboratories,; Beckenham, Kent, UK.; BACKGROUND: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively weak inhibitor of the enzyme for P. carinii. Determination of the thr
AIDS and long term care: update from the 10th international AIDS conference.: Director. 1994 Fall;2(4):145-7. Unique Identifier : AIDSLINE MED/95171160; Brown JW
AIDS and discrimination: the Windsor case [see comments]: J Can Dent Assoc. 1995 Jan;61(1):25-7. Unique Identifier : AIDSLINE MED/95171305; Crawford PR
Iron differentially modulates the CD4-lck and CD8-lck complexes in resting peripheral blood T-lymphocytes.: Cell Immunol. 1995 Mar;161(1):138-42. Unique Identifier : AIDSLINE MED/95171467; Arosa FA; de Sousa M; Abel Salazar Institute for the Biomedical Sciences, Porto,; Portugal.; Clinical and experimental studies performed in situations of iron overload have demonstrated that iron impairs several T-cell functions. We have examined the effect of iron in the form of ferric citrate on the CD4-lck and CD8-lck complexes in view of the key role played by the tyrosine kinase p56lck in regulating T-ce
IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation.: Cell Immunol. 1995 Mar;161(1):14-21. Unique Identifier : AIDSLINE MED/95171468; Radrizzani M; Accornero P; Amidei A; Aiello A; Delia D; Kurrle R; Colombo MP; Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan,; Italy.; The aim of our work was to study apoptosis as a possible mechanism of CD4+ lymphocyte depletion in AIDS patients and to test whether IL-12 could limit this phenomenon. As an in vitro model, we used a human IL-2-dependent Th1 clone from an uninfected individual. We found that CD4 cross-linking, obtained either by mouse
Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny.: Cell Immunol. 1995 Mar;161(1):22-7. Unique Identifier : AIDSLINE MED/95171469; Roberts JL; Sharrow SO; Singer A; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.; Cell surface TCR expression by developing thymocytes is actively regulated during ontogeny. Whereas most immature CD4+CD8+ thymocytes express low levels of TCR alpha beta, mature CD4+ and CD8+ thymocytes express significantly higher levels of surface TCR. Low TCR expression on CD4+CD8+ thymocytes is due, at least in p
Multiple CTL specificities against autologous HIV-1-infected BLCLs.: Cell Immunol. 1995 Mar;161(1):34-41. Unique Identifier : AIDSLINE MED/95171471; Ahearne PM; Morgan RA; Sebastian MW; Bolognesi DP; Weinhold KJ; Department of Surgery, Duke University Medical Center, Durham,; North Carolina 27710.; The cellular immune response to HIV-1 has been well studied but, in many respects, remains incompletely defined. Although CTL specificities against highly conserved HIV-1 determinants as dictated by vaccinia/HIV-1 vector constructs have been described, much less is known regarding patient cellular reactivities against
Actinobacillus (Pasteurella) ureae meningitis in a HIV-positive patient.: Diagn Microbiol Infect Dis. 1994 Oct;20(2):105-7. Unique Identifier : AIDSLINE MED/95171700; Kaka S; Lunz R; Klugman KP; Department of Medical Microbiology, University of the; Witwatersrand, South African Institute for Medical Research,; Johannesburg.; Actinobacillus (Pasteurella) ureae is a commensal of the human nasopharynx that is a rare cause of meningitis. We present an HIV-infected patient with this condition. His case, and those previously reported in the literature, implicate head trauma or a neurosurgical procedure in the pathogenesis of this condition. The
Allergic contact dermatitis in HIV-positive patients.: Contact Dermatitis. 1994 Nov;31(5):326-7. Unique Identifier : AIDSLINE MED/95171735; Viraben R; Aquilina C; Cambon L; Bazex J; Service de Dermatologie, Hopital La Grave, Toulouse, France.
Influence of iron deficiency on serum IgG subclass and pneumococcal polysaccharides specific IgG subclass antibodies.: Chin Med J (Engl). 1994 Nov;107(11):813-6. Unique Identifier : AIDSLINE MED/95171790; Feng XB; Yang XQ; Shen J; Children's Hospital, Chongqing University of Medical Sciences.; The serum IgG subclass concentrations in 47 cases and specific IgG subclass antibodies against pneumococcal polysaccharides (PnPs) were measured in 18 cases with iron deficiency. IgG subclass deficiencies were found in 28 (59.6%) cases with the frequency in order as IgG4 (27.7%, 13/47), IgG1 (21.3%, 10/47), IgG3 (14.9
Fine-needle aspiration biopsy of salivary gland mycoses.: Diagn Cytopathol. 1994;11(3):286-90. Unique Identifier : AIDSLINE MED/95171881; Raab SS; Thomas PA; Cohen MB; Department of Pathology, University of Iowa, Iowa City.; This report details the fine-needle aspiration biopsy (FNAB) cytomorphologic features of two cases of salivary gland mycosis. Both patients had acquired immunodeficiency syndrome (AIDS) and presented with parotid gland masses. The first patient had Histoplasmosis with secondary infection by Candida. Cytopathologically
AIDS research: are we in the right direction? [editorial]: East Afr Med J. 1994 Aug;71(8):481-2. Unique Identifier : AIDSLINE MED/95171945; Ndinya-Achola JO
Demographic and AIDS-related characteristics of consenters to a population-based HIV-survey: results from a pilot study in Arusha, Tanzania.: East Afr Med J. 1994 Aug;71(8):483-9. Unique Identifier : AIDSLINE MED/95171946; Ole-King'Ori N; Klepp KI; Kissila PE; Biswalo PM; Mnyika KS; Tanzanian-Norwegian AIDS Project (MUTAN), Arusha.; The aim was to compare demographic and AIDS-related characteristics of people who consented to HIV-testing as part of a population survey with those who did not consent to HIV-testing. Subjects, aged 15-54 years, living in ten randomly selected clusters of households in one ward of Arusha town were asked to participat
Human immunodeficiency virus- 1 in leprosy patients attending Kenyatta National Hospital, Nairobi.: East Afr Med J. 1994 Aug;71(8):490-2. Unique Identifier : AIDSLINE MED/95171947; Munyao TM; Bwayo JJ; Owili DM; Ndinya-Achola JO; Kwasa TO; Kreiss JK; Department of Medicine, College of Health Sciences, University of; Nairobi.; The purpose of this study was to determine if Mycobacterium leprae is an opportunistic pathogen in immunosuppressed subjects with HIV infection. Ninety six leprosy patients at Infectious Diseases Hospital (IDH), Nairobi were screened for, HIV-1 antibody between January 1991 and June 1992. The patients included 15 who
Therapeutic effect of an anti-HIV candidate vaccine.: East Afr Med J. 1994 Aug;71(8):493-5. Unique Identifier : AIDSLINE MED/95171948; Lurhuma Z; Wane J; Mbayo K; Karhemere B; Laboratoire d'Immunologie, KINSHASA XI Republique du Zaire.; A chimpanzee infected with the HIV since 8 months and presenting regularly with antigenemia was inoculated with a candidate vaccine. It received 3 doses, one dose every 15 days. Thirty days after the third injection, we noted the disappearance of the HIV antigens in the serum and its persistence in the lysate of the c
Endoscopic study of African AIDS patients with upper gastrointestinal symptoms.: East Afr Med J. 1994 Aug;71(8):496-500. Unique Identifier : AIDSLINE MED/95171949; Elshazly MA; Serwadda DM; Freers J; Department of Medicine, Mulago Hospital, Makerere University,; Uganda.; This study was carried out to investigate the endoscopic and histopathological findings in AIDS patients in Mulago Hospital, in Uganda who present with upper gastrointestinal symptoms. Any observed morphological changes were biopsied. Duodenal contents were aspirated in each case f
Nucleocytoplasmic transport of the Rev protein of human immunodeficiency virus type 1 is dependent on the activation domain of the protein.: Exp Cell Res. 1995 Mar;217(1):31-41. Unique Identifier : AIDSLINE MED/95172149; Wolff B; Cohen G; Hauber J; Meshcheryakova D; Rabeck C; Sandoz Research Institute, Vienna, Austria.; The human immunodeficiency virus type 1 (HIV-1) regulatory protein Rev, which is required for the cytoplasmic expression of unspliced and incompletely spliced viral mRNAs, is located predominantly in the nucleolus. In this study, we show that Rev translocates from the nucleolus to the cytoplasm in HeLa and COS cells t
Reproductive health and AIDS-related services for women: how well are they integrated?: Fam Plann Perspect. 1994 Nov-Dec;26(6):264-9. Unique Identifier : AIDSLINE MED/95172208; Daley D; Alan Guttmacher Institute (AGI), Washington, D.C.; To explore the relationship between human immunodeficiency virus (HIV) and AIDS services and reproductive health services, a survey was undertaken in 1994 of 30 health care facilities that are grantees under Title IIIb of the Ryan White Comprehensive AIDS Resource Emergency Act, 19 family planning clinics that offer a
Microsporidial keratoconjunctivitis treated successfully with a short course of fumagillin [letter]: Eye. 1994;8 ( Pt 6):703-4. Unique Identifier : AIDSLINE MED/95172276; Wilkins JH; Joshi N; Margolis TP; Cevallos V; Dawson CR
TH1 cells trigger tumor necrosis factor alpha-mediated hypersensitivity to Pseudomonas aeruginosa after adoptive transfer into SCID mice.: Infect Immun. 1995 Mar;63(3):1107-12. Unique Identifier : AIDSLINE MED/95172707; Fruh R; Blum B; Mossmann H; Domdey H; von Specht BU; Chirurgische Universitatsklinik, Chirurgische Forschung,; Freiburg, Germany.; Recent experiments have shown that gamma interferon (IFN-gamma), either administered or induced in vivo, e.g., by certain bacteria, is a key mediator in inducing hypersensitivity to bacterial lipopolysaccharides. The source of endogenous IFN-gamma in this context (natural killer versus TH1 cells) has not been investig
Interleukin-10 downregulates protective immunity to Brucella abortus.: Infect Immun. 1995 Mar;63(3):1130-3. Unique Identifier : AIDSLINE MED/95172712; Fernandes DM; Baldwin CL; Department of Microbiology, Ohio State University, Columbus; 43210.; In vivo neutralization of interleukin-10 (IL-10) with an anti-IL-10 monoclonal antibody resulted in up to 10-fold fewer bacteria in the spleens of BALB/c mice infected with the virulent Brucella abortus strain 2308. In vitro neutralization of endogenous IL-10 in brucella antigen-stimulated cultures of splenocytes from
Methionine enkephalin combined with AZT therapy reduce murine retrovirus-induced disease.: Int J Immunopharmacol. 1994 Nov;16(11):911-7. Unique Identifier : AIDSLINE MED/95172775; Specter S; Plotnikoff N; Bradley WG; Goodfellow D; Department of Medical Microbiology and Immunology, University of; South Florida College of Medicine, Tampa 33612.; AZT (7.5 or 15 mg/kg/dose) and the neuropeptide methionine enkephalin (Met-ENK, 1 or 3 mg/kg/dose) were used in a combined protocol for therapy of established murine retroviral infection. In both models used, Friend virus leukemia (FV) and BM5 complex
Granulocyte defects and opioid receptors in chronic exposure to heroin or methadone in humans.: Int J Immunopharmacol. 1994 Nov;16(11):959-67. Unique Identifier : AIDSLINE MED/95172780; Mazzone A; Mazzucchelli I; Fossati G; Gritti D; Fea M; Ricevuti G; Department of Internal Medicine and Therapeutics, University of; Pavia, IRCCS San Matteo Hospital, Italy.; In order to elucidate better the immunological effect of opioid abuse in the absence of HIV infection as a confounding factor, granulocyte function was investigated in three groups of HIV-negative subjects, including 20 active parenteral heroin abusers (H), 20 long-term methadone-maintained former opiate abusers (M) a
Explaining long-term HIV survivors [news]: Int Nurs Rev. 1994 Nov-Dec;41(6):169-70. Unique Identifier : AIDSLINE MED/95172791; Merson MH
Toxicity of clarithromycin in the treatment of Mycobacterium avium complex infection in a patient with AIDS [letter]: J Antimicrob Chemother. 1994 Oct;34(4):605-6. Unique Identifier : AIDSLINE MED/95172912; Dorrell L; Ellerton C; Cottrell DG; Snow MH
Effect of hyperbaric oxygen on tissue distribution of mononuclear cell subsets in the rat.: J Appl Physiol. 1994 Nov;77(5):2355-9. Unique Identifier : AIDSLINE MED/95172954; Bitterman N; Lahat N; Rosenwald T; Kinarty A; Melamed Y; Bitterman H; Israel Naval Medical Institute, Haifa, Israel.; In a previous study we found a significant temporary decrease in the ratio of CD4/CD8 (helper, inducer/suppressor, cytotoxic) T lymphocytes in the peripheral blood of healthy human volunteers after exposure to a single commonly used profile of hyperbaric oxygen (HBO). The transient nature of the changes suggested redi
New regulatory CD4 reporting to assist Arkansas AIDS case surveillance.: J Ark Med Soc. 1995 Jan;91(8):403-4. Unique Identifier : AIDSLINE MED/95172976; Bunch J; Arkansas Department of Health.
An HIV-1 protease screening assay using a non-infectious proviral clone.: J Virol Methods. 1994 Oct;49(3):247-55. Unique Identifier : AIDSLINE MED/95173146; Heldsinger AA; Antonucci T; Department of Infectious Diseases, Parke-Davis Pharmaceutical; Research, Division of Warner-Lambert Company, Ann Arbor, MI; 48105.; An in-vitro assay was developed to screen for HIV-1 protease inhibitors using a non-infectious proviral clone (X19) with a deletion in the envelope gene (Ratner et al., 1991). The proviral clone, X19, was expressed transiently in the COS 7 cell line. The virus was a
Same-day testing for human immunodeficiency virus antibodies.: J Virol Methods. 1994 Oct;49(3):367-70. Unique Identifier : AIDSLINE MED/95173158; Morris DJ; Corbitt G; Crosdale E; North Manchester Virus Laboratory, Booth Hall Children's; Hospital, Blackley, Manchester, UK.; We analysed the specificity of a screening enzyme-linked immunosorbent assay for human immunodeficiency virus antibodies, and found that 18 of 1878 serum specimens (1.0%) from an open access clinic gave false reactive results. Introduction of true same-day testing therefore required the use of more than one assay befo
CD8-positive tumor-infiltrating lymphocytes influence the long-term survival of patients with mycosis fungoides.: J Am Acad Dermatol. 1995 Mar;32(3):448-53. Unique Identifier : AIDSLINE MED/95173220; Hoppe RT; Medeiros LJ; Warnke RA; Wood GS; Department of Radiation Oncology, Stanford University, CA.; BACKGROUND: Nonneoplastic mononuclear cells commonly infiltrate lesions of mycosis fungoides. OBJECTIVE: We sought to determine the immunophenotypic characteristics of these cells and to determine whether the presence of CD8+ tumor-infiltrating lymphocytes has an impact on prognosis. METHODS: Skin biopsy specimens fro
Bacillary angiomatosis of the skin and bone marrow in a patient with HIV infection.: J Am Acad Dermatol. 1995 Mar;32(3):510-2. Unique Identifier : AIDSLINE MED/95173230; Fagan WA; Skinner SM; Ondo A; Williams JT; Anthony K; DeVillez RL; Pulitzer DR; Division of Dermatology, University of Texas Health Science; Center, San Antonio 78284-7876.
Paradoxical coexistence of contact dermatitis and anergy in a man with AIDS.: J Am Acad Dermatol. 1995 Mar;32(3):526-7. Unique Identifier : AIDSLINE MED/95173240; Finesmith TH; Seaman S; Rietschel R; Tulane School of Medicine, New Orleans, LA.
HIV antibodies among intravenous drug users in Bahrain.: J Commun Dis. 1994 Sep;26(3):127-32. Unique Identifier : AIDSLINE MED/95173344; al-Haddad MK; Khashaba AS; Baig BZ; Khalfan S; Psychiatric Hospital, Bahrain, Arabian Gulf.; A 12-month study was conducted to identify risk factors for human immunodeficiency virus (HIV) infections among intravenous drug users (IDU) attending drug rehabilitation clinic of the Psychiatric Hospital, Manama, Bahrain . Patients provided demographic and behavioural information
Community based survey of STD/HIV infection among commercial sexworkers in Calcutta (India). Part I. Some social features of commercial sexworkers.: J Commun Dis. 1994 Sep;26(3):161-7. Unique Identifier : AIDSLINE MED/95173350; Chakraborty AK; Jana S; Das A; Khodakevich L; Chakraborty MS; Pal NK; All India Institute of Hygiene and Public Health, Calcutta.; A community based sample survey of sexually transmitted diseases and Human Immuno deficiency Virus infection was carried out among commercial sex workers of a red-light area in Calcutta. In this paper socio-demographic aspects of sex workers are discussed. For the survey, 450 sex workers were selected by random sampli
Community based survey of STD/HIV infection among commercial sex-workers in Calcutta (India). Part II. Sexual behaviour, knowledge and attitude towards STD.: J Commun Dis. 1994 Sep;26(3):168-71. Unique Identifier : AIDSLINE MED/95173351; Jana S; Chakraborty AK; Das A; Khodakevich L; Chakraborty MS; Pal NK; All India Institute of Hygiene and Public Health, Calcutta.; A community based sample survey of STD/HIV infections was carried out among 450 commercial sex workers, (CSW) of one red light area in Calcutta. In this paper, sexual practices of sex workers, their knowledge about sexually transmitted diseases (STD) and practice of preventive and curative measures against STDs, is de
Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies.: J Histochem Cytochem. 1995 Mar;43(3):313-20. Unique Identifier : AIDSLINE MED/95173388; Whiteland JL; Nicholls SM; Shimeld C; Easty DL; Williams NA; Hill TJ; Department of Ophthalmology, University of Bristol, United; Kingdom.; We describe a method for immunohistochemical localization of T-cells, CD4+ T-cells, CD8+ T-cells, B-cells, activated lymphocytes, major histocompatibility complex (MHC) class II antigens, macrophages, dendritic cells, and granulocytes in rat and mouse tissue fixed in periodate-lysine-paraformaldehyde (PLP) and embedde
Sequence constraints and recognition by CTL of an HLA-B27-restricted HIV-1 gag epitope.: J Immunol. 1995 Mar 1;154(5):2189-97. Unique Identifier : AIDSLINE MED/95173425; Nietfield W; Bauer M; Fevrier M; Maier R; Holzwarth B; Frank R; Maier B; Riviere Y; Meyerhans A; Department of Virology, University of Freiburg, Germany.; Previous studies on the variation of an immunodominant HLA-B27-restricted HIV-1 gag p24 epitope (KRWIIL GLNK, amino acids 263-272) have demonstrated the persistence of variants recognized by CTL. Sequence comparisons of HIV isolates showed that this region is relatively conserved and as a consequence might restrict an
Characterization of RFM mouse T lymphocyte anti-oncofetal antigen immunity in apparent tumor-free, long-term survivors of sublethal X-irradiation by limiting dilution T lymphocyte cloning.: J Immunol. 1995 Mar 1;154(5):2266-80. Unique Identifier : AIDSLINE MED/95173433; Rohrer JW; Culpepper C; Barsoum AL; Coggin JH Jr; University of South Alabama College of Medicine, Department of; Microbiology and Immunology, Mobile 36688.; Fractionated sublethal x-irradiation induces thymic lymphomas in up to 60% of RFM mice by 6 mo after irradiation, but no thymomas arise after 6 mo. All radiation-induced tumors expressed oncofetal Ag (OFA) and thymic OFA expression significantly preceded detectable thymomas. To determine whether lymphoma-free, radiati
HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines.: J Immunol. 1995 Mar 1;154(5):2448-59. Unique Identifier : AIDSLINE MED/95173451; Kinter AL; Poli G; Fox L; Hardy E; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.; Replication of HIV is regulated by virus-encoded regulatory proteins, as well as by a variety of cellular factors including cytokines. In the present study, we have investigated the autocrine/paracrine effects of endogenous cytokines on HIV replication in primary PBMCs of healthy HIV seronegative individuals. Addition
Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.: J Immunol. 1995 Mar 1;154(5):2494-503. Unique Identifier : AIDSLINE MED/95173455; Santamaria P; Utsugi T; Park BJ; Averill N; Kawazu S; Yoon JW; Department of Microbiology and Infectious Diseases, Faculty of; Medicine, University of Calgary, Alberta, Canada.; Insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice results from a cell-mediated autoimmune process against pancreatic beta-cells. We have shown that beta-cell-cytotoxic CD8+ T cell clones can transfer IDDM to irradiated NOD mice if co-injected with nondiabetogenic CD4+ spleen T cells. To determ
Leprosy and infection with the human immunodeficiency virus in Uganda; a case-control study.: Int J Lepr Other Mycobact Dis. 1994 Dec;62(4):521-6. Unique Identifier : AIDSLINE MED/95173492; Kawuma HJ; Bwire R; Adatu-Engwau F; St. Francis Leprosy Centre Buluba, Jinga, Uganda.; Both leprosy and infection with the human immunodeficiency virus (HIV) are endemic in Uganda . Various speculations about a possible interaction between the two infections have been put forward but not confirmed. A case-control study involving 189 new leprosy patients and 481 matche
Prevalence of HIV infection and high-risk characteristics among leprosy patients of south India; a case-control study.: Int J Lepr Other Mycobact Dis. 1994 Dec;62(4):527-31. Unique Identifier : AIDSLINE MED/95173493; Sekar B; Jayasheela M; Chattopadhya D; Anandan D; Rathinavel L; Vasanthi B; Subramanian M; Rao PS; Laboratory Division, Central Leprosy Teaching and Research; Institute, Tamil Nadu, South India.; With the observation of the occurrence of the human immunodeficiency virus (HIV) infection among leprosy patients in our pilot study carried out in Tamil Nadu, South India , a case-control study was planned to explore whether HIV infection is a risk factor for leprosy and to understa
HIV-1 infection and leprosy [letter; comment]: Int J Lepr Other Mycobact Dis. 1994 Dec;62(4):610-3. Unique Identifier : AIDSLINE MED/95173506; Gormus BJ
The prevalence of HIV infection among mentally ill offenders in Thailand.: J Med Assoc Thai. 1994 May;77(5):257-60. Unique Identifier : AIDSLINE MED/95173552; Dasananjali T; Department of Medical Services, Ministry of Public Health,; Nonthaburi, Thailand.; The study was made at Nitichitawej Hospital in 1988 to find the prevalence among mentally ill offenders whom had detained there. The total of 325 cases were investigated by gel agglutination and confirmed by W-B analysis. A total of 81.5 per cent were mentally ill and the 1.85 per cent of these were HIV infected. Amon
Seroprevalence of HIV antibodies and risk factors in healthy young males from upper north Thailand.: J Med Assoc Thai. 1994 Jun;77(6):288-92. Unique Identifier : AIDSLINE MED/95173558; Theetranont C; Suprasert S; Matanasarawoot A; Romyen S; Tulvatana S; Nelson KE; Celentanao DD; Wright N; Faculty of Medicine, Chiang Mai University, Thailand.; In the Spring of 1991 a random sample of young men from Upper Northern Thailand (mean age = 21 years) was interviewed by trained medical students from Chiang Mai University, serum samples were obtained and analyzed for prevalence of HIV-1 antibodies and for syphilis, and risk fac
Disseminated cryptococcosis presenting as molluscum-like lesions in three male patients with acquired immunodeficiency syndrome.: J Med Assoc Thai. 1994 Jun;77(6):322-6. Unique Identifier : AIDSLINE MED/95173563; Chiewchanvit S; Chuaychoo B; Mahanupab P; Department of Internal Medicine, Faculty of Medicine, Chiang Mai; University, Thailand.; Cryptococcosis is an opportunistic infection caused by a ubiquitous encapsulated yeast, Cryptococcus neoformans. The pulmonary infection is primary site and most frequently self-limited and may be asymptomatic. The most common recognized site of disseminated cryptococcosis is the central nervous system. The cutaneous
Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia.: J Exp Med. 1995 Mar 1;181(3):1229-33. Unique Identifier : AIDSLINE MED/95173592; Coyle AJ; Erard F; Bertrand C; Walti S; Pircher H; Le Gros G; Department of Asthma and Allergy, CIBA-GEIGY Ltd., Basel,; Switzerland.; Virus infections of the lung are thought to predispose individuals to asthma, a disease characterized by eosinophil infiltration of the airways. CD8+ T cells are an important part of the host response to virus infection, however, they have no reported role in eosinophil recruitment. We developed a mouse model of virus
Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids.: J Exp Med. 1995 Mar 1;181(3):901-14. Unique Identifier : AIDSLINE MED/95173605; Orange JS; Salazar-Mather TP; Opal SM; Spencer RL; Miller AH; McEwen BS; Biron CA; Division of Biology and Medicine, Brown University, Providence,; Rhode Island 02912.; Interleukin 12 (IL-12) doses in excess of 100 ng/d have been shown to induce profound immunotoxicities in mice infected with lymphocytic choriomeningitis virus (LCMV). These immunotoxicities are characterized by almost complete inhibition of virus-induced CD8+ T cell expansion and CTL activation, and up to 2 log incre
Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response.: J Exp Med. 1995 Mar 1;181(3):961-71. Unique Identifier : AIDSLINE MED/95173610; Swihart K; Fruth U; Messmer N; Hug K; Behin R; Huang S; Del Giudice G; Aguet M; Louis JA; World Health Organization Immunology Research and Training; Center, University of Lausanne, Epalinges, Switzerland.; Mice with homologous disruption of the gene coding for the ligand-binding chain of the interferon (IFN) gamma receptor and derived from a strain genetically resistant to infection with Leishmania major have been used to study further the role of this cytokine in the differentiation of functional CD4+ T cell subsets in
Chemiluminescent immunoassays: discrimination between the reactivities of natural and human patient antibodies with antigens from eukaryotic pathogens, Trypanosoma cruzi and Paracoccidioides brasiliensis.: J Clin Lab Anal. 1994;8(6):424-31. Unique Identifier : AIDSLINE MED/95173760; Almeida IC; Rodrigues EG; Travassos LR; Disciplina de Biologia Celular, Escola Paulista de Medicina, Sao; Paulo, Brazil.; Quantitative chemiluminescent enzyme-linked immunosorbent assay (ELISA) and dot-blotting procedures were developed to evaluate the reactivity of human antibodies with crude antigens and purified molecules of parasites and fungi, mainly Trypanosoma cruzi and Paracoccidioides brasiliensis. Reproducible, highly sensitive
Solid-phase polymerase chain reaction.: J Clin Lab Anal. 1994;8(6):452-5. Unique Identifier : AIDSLINE MED/95173765; Kohsaka H; Carson DA; Department of Medicine, University of California, San Diego, La; Jolla 92093-0663.; The polymerase chain reaction (PCR) has facilitated the diagnosis of infectious diseases and genetic disorders, because of its ability to amplify minute amounts of nucleic acids. To distinguish genes of interest from nonspecifically amplified DNA, PCR products commonly are fractionated by electrophoresis, transferred
HLA antigens and resistance to HIV.: J Clin Lab Anal. 1994;8(6):456-8. Unique Identifier : AIDSLINE MED/95173766; Peixinho ZF; Mendes NF; Escola Paulista de Medicina, Division of Immunology, Sao Paulo,; Brasil.; The role of histocompatibility antigens in HIV infection has been investigated by several approaches. Thus the haplotype A1B8DR3 that is usually linked to autoimmune disorders seems to be associated with accelerated progression to AIDS. Cross-reactivity between MHC antigens and HIV-1 proteins is evident from alloimmun
Immunologic characterization of children vertically infected with human immunodeficiency virus, with slow or rapid disease progression.: J Pediatr. 1995 Mar;126(3):368-74. Unique Identifier : AIDSLINE MED/95173772; Vigano A; Principi N; Villa ML; Riva C; Crupi L; Trabattoni D; Shearer GM; Clerici M; Cattedra di Pediatria IV, H. L. Sacco, Milan, Italy.; Cytokine production of unstimulated and mitogen-stimulated peripheral blood mononuclear cells of 31 children vertically infected with human immunodeficiency virus type 1 (HIV) and with different patterns of disease progression was evaluated to establish possible correlations between the immunologic and the clinical fi
Cognitive assessment of school-age children infected with maternally transmitted human immunodeficiency virus type 1.: J Pediatr. 1995 Mar;126(3):375-9. Unique Identifier : AIDSLINE MED/95173773; Tardieu M; Mayaux MJ; Seibel N; Funck-Brentano I; Straub E; Teglas JP; Blanche S; Departement de Pediatrie, Unite INSERM U292, Hopital de; Bicetre, Paris, France.; Thirty-three children vertically infected with human immunodeficiency virus type 1 (HIV-1), who were born before 1985, were followed in a single center, and had reached the age of 6 years, were studied and tested for school achievement. Of these 33 children, 24 were also tested for cognitive abilities, fine motor and
Lymphocyte subpopulations in patients with primary fibromyalgia.: J Rheumatol. 1994 Nov;21(11):2122-4. Unique Identifier : AIDSLINE MED/95173910; Hernanz W; Valenzuela A; Quijada J; Garcia A; de la Iglesia JL; Gutierrez A; Povedano J; Moreno I; Sanchez B; Rheumatology Service, Hospital Universitario Virgen Del Rocio,; Sevilla, Spain.; OBJECTIVE. Fibromyalgia (FM) is a clinical entity of unknown etiology frequently diagnosed in rheumatology. The potential involvement of the immune system in its pathogenesis has been suggested. Studies of abnormal T cell subpopulations often have been inconclusive. We attempted to clear this point by comparing lympho
Early helper T-cell dysfunction in simian immunodeficiency virus but not in human immunodeficiency virus type-2-infected macaques.: J Med Primatol. 1994 Jul;23(5):298-303. Unique Identifier : AIDSLINE MED/95173948; Dittmer U; Luke W; Stahl-Hennig C; Coulibaly C; Petry H; Bodemer W; Hunsmann G; Voss G; Deutsches Primatenzentrum, Abteilung Virologie und Immunologie,; Gottingen, Germany.; Both naive and vaccinated macaques acquired a virus-specific proliferative helper T-cell reactivity in response to infection with the nonpathogenic human immunodeficiency virus type 2 (HIV-2). In contrast, macaques infected with the pathogenic simian immunodeficiency virus of the macaque strain (SIVmac) did not develo
Cryptosporidiosis of liver and pancreas in rhesus monkeys with experimental SIV infection.: J Med Primatol. 1994 Jul;23(5):304-8. Unique Identifier : AIDSLINE MED/95173949; Kaup FJ; Kuhn EM; Makoschey B; Hunsmann G; Working Group of Experimental Pathology, F.R.G..; Following an experimental SIV infection, 11 rhesus monkeys were evaluated to determine the presence of opportunistic infections. Five animals had severe alterations of the hepatobiliary tree, three of which were associated with the presence of numerous Cryptosporidium spp. Subacute to chronic inflammatory changes were
Compliance with public sector HIV medical care.: J Natl Med Assoc. 1995 Jan;87(1):19-24. Unique Identifier : AIDSLINE MED/95173997; Kissinger P; Cohen D; Brandon W; Rice J; Morse A; Clark R; Louisiana State University, Dept of Medicine-Section of HIV, New; Orleans 70112.; Despite the availability of free or low-cost public sector human immunodeficiency virus (HIV) health-care services, important inequities in utilization exist. This study examined two measures of compliance with HIV medical care: attendance of scheduled outpatient visits and use of the emergency room. Clients of two pu
Methadone maintenance counseling. Definition, principles, components.: J Subst Abuse Treat. 1994 Sep-Oct;11(5):405-13. Unique Identifier : AIDSLINE MED/95174058; Hagman G; Montefiore Medical Center, Department of Family Medicine, Bronx,; New York 10467.; Counseling has been a major service component of methadone maintenance since its inception. Yet, there is no consensus about what methadone counseling is or how it should be practiced. This paper proposes a definition of professional methadone counseling as a specialized modality of addiction therapy and rehabilitatio
Factors associated with employment among methadone patients.: J Subst Abuse Treat. 1994 Sep-Oct;11(5):443-7. Unique Identifier : AIDSLINE MED/95174062; Zanis DA; Metzger DS; McLellan AT; Penn-VA Center for Studies of Addiction, Philadelphia Veterans; Administration Medical Center 19104.; We examined the patient characteristics of 340 subjects in methadone treatment to determine if these characteristics could differentiate among three stages of work during the past year (stable unemployment, intermittent work, and stable employment). A multiple discriminant function analysis was able to classify correc
Lifetime needle sharing: a predictive analysis.: J Subst Abuse Treat. 1994 Sep-Oct;11(5):449-55. Unique Identifier : AIDSLINE MED/95174063; Kleinman PH; Millman RB; Robinson H; Lesser M; Hsu C; Engelhart P; Finkelstein I; Cornell University Medical College (CUMC), Dept. Public Health,; New York, NY 10021.; Through understanding predictors of needle sharing, it may be possible to design AIDS prevention interventions more effectively. Data were collected from a sample of 416 patients in two New York City methadone programs in 1990. Questions were asked about needle sharing and about a battery of predictors covering 11 psy
Illicit use of methadone among i.v. drug users in Montreal.: J Subst Abuse Treat. 1994 Sep-Oct;11(5):457-61. Unique Identifier : AIDSLINE MED/95174064; Lauzon P; Vincelette J; Bruneau J; Lamothe F; Lachance N; Brabant M; Soto J; Detoxification Unit, Hopital Saint-Luc, Montreal, Quebec,; Canada.; Few studies have been done on the prevalence of illicit methadone use. Five hundred fifty-nine IV drug users recruited in various ways in Montreal were interviewed concerning their drug use as part of a longitudinal study on HIV infection. Of this number, 133 had heroin as their drug of preference and 426 cocaine. Amo
HIV antibody testing and client retention in the therapeutic community. A preliminary report of Phoenix House.: J Subst Abuse Treat. 1994 Sep-Oct;11(5):481-8. Unique Identifier : AIDSLINE MED/95174067; Gonzalez I; Rosenthal MS; Bigler MO; Alper K; Geringer W; Phoenix House Foundation, New York, New York.; This report describes the current approach to testing for the human immunodeficiency virus (HIV) antibody at Phoenix House, a large therapeutic community (TC) in the northeastern United States , and presents findings on retention of clients who have been tested for HIV antibodies and no
Prophylaxis against Pneumocystis carinii pneumonia at higher CD4+ T-cell counts [letter]: JAMA. 1995 Mar 15;273(11):848. Unique Identifier : AIDSLINE MED/95174153; Chu SY; Hanson DL; Ciesielski C; Ward JW
HIV transmission through donor artificial insemination [see comments]: JAMA. 1995 Mar 15;273(11):854-8. Unique Identifier : AIDSLINE MED/95174155; Araneta MR; Mascola L; Eller A; O'Neil L; Ginsberg MM; Bursaw M; Marik J; Friedman S; Sims CA; Rekart ML; et al; Los Angeles County Department of Health Services, CA.; OBJECTIVE--To investigate and report cases of human immunodeficiency virus (HIV) transmission through donor artificial insemination (AI) before 1986 at five infertility clinics. DESIGN--Two types of look-back studies were performed: (1) identification of an HIV-infected woman who reported previous AI, followed by iden
Artificial insemination by donor. Safety and secrecy [editorial; comment]: JAMA. 1995 Mar 15;273(11):890-1. Unique Identifier : AIDSLINE MED/95174163; Guinan ME
[Problems in the diagnosis of AIDS]: Rinsho Byori. 1994 Dec;42(12):1248-52. Unique Identifier : AIDSLINE MED/95174189; Matsushita S; Transfusion Service Department, Kumamoto University School of; Medicine.; Diagnosis of human immunodeficiency virus (HIV) infection depends mainly on the detection of HIV-specific antibodies in the serum. If a seropositive patient has symptoms and signs of AIDS indicator diseases he (or she) will be diagnosed as having AIDS. If a patient is seronegative to HIV, some other diseases should be
[Problems concerned with adult T-cell leukemia. 1) Causes of death and early diagnosis of cytomegalovirus pneumonia in adult T-cell leukemia. 2) Clinicopathological features of CD30 positive adult T-cell leukemia]: Rinsho Byori. 1994 Dec;42(12):1253-60. Unique Identifier : AIDSLINE MED/95174190; Kikuchi H; Ono K; Ohtsuka E; Tokimatsu I; Tashiro T; Nasu M; Sonoda Y; Yokoyama S; 2nd Department of Internal Medicine, Oita Medical University.; 1) We studied the causes of death confirmed by autopsy or necropsy in 23 adult T-cell leukemia (ATL) patients. Of them eight showed involvement of tumor (35%), eleven infectious disease (47%) (nine cytomegalovirus ( CMV ) pneum
Neopterin--its clinical use in urinalysis.: Kidney Int Suppl. 1994 Nov;47:S8-11. Unique Identifier : AIDSLINE MED/95174293; Fuchs D; Stahl-Hennig C; Gruber A; Murr C; Hunsmann G; Wachter H; Institute of Medical Chemistry and Biochemistry, University of; Innsbruck, Austria.; Increased amounts of neopterin are released during cellular immune response. Neopterin concentrations can be monitored in serum and urine of patients since neopterin is removed from the circulation by renal excretion. In allograft recipients, rising neopterin concentrations indicate rejection episodes early. Neopterin
Defective escape mutants of HIV.: J Theor Biol. 1994 Dec 21;171(4):387-95. Unique Identifier : AIDSLINE MED/95174375; Berry RM; Nowak MA; Department of Zoology, University of Oxford, U.K.; The virological literature presents two broad types of defective virus mutants that can alter the outcome of viral infection. In some infections, defective interfering particles reduce the replication of wild-type virus and lead to an attenuated or persistent infection. In other cases, very specific and highly pathoge
The hospital in the home [interview by Peter Schwab]: Lamp. 1994 May;51(4):21. Unique Identifier : AIDSLINE MED/95174472; Redmond K
CD8+ T lymphocytes are the major cell population involved in the early gamma interferon response and resistance to acute primary Toxoplasma gondii infection in mice.: Microbiol Immunol. 1994;38(10):789-96. Unique Identifier : AIDSLINE MED/95174620; Shirahata T; Yamashita T; Ohta C; Goto H; Nakane A; Department of Veterinary Microbiology, Obihiro University of; Agriculture and Veterinary Medicine, Hokkaido, Japan.; Gamma interferon (IFN-gamma) is known to be a major mediator influencing host defense against Toxoplasma (T.) gondii. To evaluate lymphocyte populations involved in this cytokine-mediated early resistance to T. gondii, the effects of in vivo administration of monoclonal antibodies (MAbs) against T-cell subsets and ant
A novel assay system for anti-human immunodeficiency virus type 1 (HIV-1) activity using a subclone of a monocytic cell line, U937.: Microbiol Immunol. 1994;38(10):813-8. Unique Identifier : AIDSLINE MED/95174625; Miyano-Kurosaki N; Nakashima H; Ichiyama K; Inazawa K; Tabata H; Tanabe H; Ohnishi K; Mizusawa H; Ohshiro Y; Yamamoto N; Department of Microbiology, Tokyo Medical and Dental University,; Japan.; A subclonal cl.1-14 cell was established from a monocytic cell line U937 by a limiting dilution method. The anti-HIV-1 activity of some antiviral compounds was evaluated in HIV-1-infected cl.1-14 cells. The results demonstrated that although AZT was a
[Clinical infectiology update. I: Diagnosis, pathogen spectrum and resistance]: Med Klin. 1994 Dec 15;89(12):652-61. Unique Identifier : AIDSLINE MED/95174665; Schrappe M; Medizinische Klinik I der, Universitat Koln.
HIV counseling and testing--United States, 1993.: MMWR Morb Mortal Wkly Rep. 1995 Mar 10;44(9):169-74. Unique Identifier : AIDSLINE MED/95174692; Counseling and testing (CT) are important components of state and local human immunodeficiency virus (HIV)-prevention programs (1). Analysis of national data sources indicates that HIV-antibody tests are obtained from a variety of testing sites, including private physicians, hospitals, and outpatient clinics (66.7%),
A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent.: Mol Pharmacol. 1995 Feb;47(2):391-7. Unique Identifier : AIDSLINE MED/95174749; Robbins BL; Connelly MC; Marshall DR; Srinivas RV; Fridland A; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee 38105.; 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) is a new antiviral agent with activity against herpes viruses and retroviruses, including human immunodeficiency virus, but its metabolism and mechanism of action remain unclear. We have isolated a human T lymphoid cell line (CEMr-1) that is resistant to the antiproliferative
Variable region light chain genes encoding human antibodies to HIV-1.: Mol Immunol. 1995 Jan;32(1):77-88. Unique Identifier : AIDSLINE GENBANK/Z34914; David D; Zouali M; Departement d'Immunologie, Institut Pasteur, Paris, France.; In previous work, it was found that the heavy chain variable gene (VH) repertoire of human antibodies to HIV is markedly skewed and that the gp120 molecule is a ligand for VH3 gene products. Here, we have analysed the light chain (L-chain) variable region genes (VL) expressed by a panel of human monoclonal antibodies
Identification of active cytomegalovirus infection by analysis of immediate-early, early and late transcripts in peripheral blood cells of immunodeficient patients.: Mol Cell Probes. 1994 Aug;8(4):261-71. Unique Identifier : AIDSLINE MED/95174770; Meyer T; Reischl U; Wolf H; Schuller C; Arndt R; Institute of Applied Immunology and Biotechnology, Hamburg,; Germany.; Owing to the persistence of viral DNA in leukocytes after primary CMV infection, detection of CMV DNA in these cells does not necessarily represent active infection. To identify CMV replication more precisely we have analysed immediate-early, early and late CMV
Rapid diagnosis of cytomegalovirus lung infection by DNA amplification in bronchoalveolar lavages.: Mol Cell Probes. 1994 Aug;8(4):273-83. Unique Identifier : AIDSLINE MED/95174771; Liesnard C; De Wit L; Motte S; Brancart F; Content J; Microbiology Laboratory, Hopital Erasme, Universite Libre de; Bruxelles, Belgium.; We used polymerase chain reaction (PCR) to detect cytomegalovirus ( CMV ) deoxyribonucleic acid (DNA) in the bronchoalveolar lavages (BAL) of 16 CMV-infected patients with active disease. We also tested PCR on a control group o
Design and evaluation of new, highly sensitive and specific primers for polymerase chain reaction detection of HIV-1 infected primary lymphocytes.: Mol Cell Probes. 1994 Aug;8(4):317-22. Unique Identifier : AIDSLINE MED/95174775; Fransen K; Zhong P; De Beenhouwer H; Carpels G; Peeters M; Louwagie J; Janssens W; Piot P; van der Groen G; Division of Microbiology, Institute of Tropical Medicine,; Antwerp, Belgium.; Primer pairs in the HIV-1 POL and ENV genes were evaluated by performing a PCR on lysed peripheral blood mononuclear cells (PBMCs) from 96 HIV-1 seropositive and 40 seronegative individuals originating from 16 different geographical localities in Africa, Europe and Haiti . A single P
Clearance of HIV infection in a perinatally infected infant [see comments]: N Engl J Med. 1995 Mar 30;332(13):833-8. Unique Identifier : AIDSLINE GENBANK/L33074; Bryson YJ; Pang S; Wei LS; Dickover R; Diagne A; Chen IS; Department of Pediatrics, UCLA School of Medicine 90024-1752.; BACKGROUND. We describe a child who was identified shortly after birth as infected with the human immunodeficiency virus type 1 (HIV-1), but whose infection appears to have completely cleared. Asymptomatic HIV-1 infection was diagnosed in the mother during the fourth month of pregnancy. The infant was delivered vagina
Clearance of HIV--lessons from newborns [editorial; comment]: N Engl J Med. 1995 Mar 30;332(13):883-4. Unique Identifier : AIDSLINE MED/95174850; McIntosh K; Burchett SK
Ethical issues in the use of zidovudine to reduce vertical transmission of HIV [letter; comment]: N Engl J Med. 1995 Mar 30;332(13):891-2. Unique Identifier : AIDSLINE MED/95174858; Hoffman CA; Munson R
Ethical issues in the use of zidovudine to reduce vertical transmission of HIV [letter; comment]: N Engl J Med. 1995 Mar 30;332(13):892. Unique Identifier : AIDSLINE MED/95174859; De Roo A; Colebunders R
Ethical issues in the use of zidovudine to reduce vertical transmission of HIV [letter; comment]: N Engl J Med. 1995 Mar 30;332(13):892. Unique Identifier : AIDSLINE MED/95174860; Thea DM
AIDS activists seek speedy access to protease drugs.... [news]: Nature. 1995 Mar 2;374(6517):4. Unique Identifier : AIDSLINE MED/95174876; Gavaghan H
US stalls over tests of marijuana to treat AIDS patients [news]: Nature. 1995 Mar 2;374(6517):7-8. Unique Identifier : AIDSLINE MED/95174884; Lehrman S
Purpose in life among gay men with HIV disease.: Nursingconnections. 1994 Winter;7(4):5-11. Unique Identifier : AIDSLINE MED/95174919; Bechtel GA; Positive purpose in life (PIL) has been shown to influence health maintenance, facilitate recovery from illness, and enhance psychological well-being. Among persons diagnosed with human immunodeficiency virus (HIV) disease, PIL has received minimal attention. This study used a convenience sample of 67 men who had a di
Lymphocyte subsets in relapsing-remitting multiple sclerosis: a longitudinal study of B lymphocytes and T lymphocytes.: Neurol Res. 1994 Oct;16(5):385-8. Unique Identifier : AIDSLINE MED/95175007; Scott TF; McKolanis J; Rothfus W; Cottington E; Department of Neurology, Medical College of Pennsylvania,; Allegheny General Hospital, Pittsburgh 15212.; Changes in lymphocyte subset populations may provide clues to the dysimmune mechanisms involved in relapsing remitting multiple sclerosis (RRMS). The lymphocyte subgroup CD4+ CD45RA+, thought to be responsible for the induction of suppression is decreased in some patients with MS compared to controls. A possible role
AIDS. BME guidelines.: N J Med. 1995 Feb;92(2):76. Unique Identifier : AIDSLINE MED/95175139
Discharge for refusing to treat HIV patients.: N J Med. 1995 Feb;92(2):76. Unique Identifier : AIDSLINE MED/95175140
Otosyphilis in a patient with human immunodeficiency virus: internal auditory canal gumma.: Otolaryngol Head Neck Surg. 1995 Mar;112(3):488-92. Unique Identifier : AIDSLINE MED/95175229; Little JP; Gardner G; Acker JD; Land MA; Department of Otolaryngology, Bowman Gray School of; Medicine/North Carolina Baptist Hospital, Winston-Salem, NC; 27157.
Human immunodeficiency virus--associated non-Hodgkin's lymphoma presenting as an auricular perichondritis.: Otolaryngol Head Neck Surg. 1995 Mar;112(3):493-5. Unique Identifier : AIDSLINE MED/95175230; Levin RJ; Henick DH; Cohen AF; Department of Otolaryngology-Head and Neck Surgery, Albert; Einstein College of Medicine-Montefiore Medical Center, Bronx,; New York.; AIDS-related NHL is an aggressive neoplasm, usually of high or intermediate grade, frequently extranodal at initial treatment, and often the first manifestation of AIDS. Although complete remissions have been reported, they occur in only a minority of patients. We describe a patient with NHL of the external ear that m
The profile of IgG1 and IgG2a antibody responses in mice exposed to Schistosoma mansoni.: Parasite Immunol. 1994 Oct;16(10):521-7. Unique Identifier : AIDSLINE MED/95175234; Mountford AP; Fisher A; Wilson RA; Department of Biology, University of York, UK.; The segregation of IgG2a and IgG1 immunoglobulin isotypes as markers for Th1 and Th2 lymphocytes respectively, was investigated in mice exposed to normal or optimally-irradiated S. mansoni cercariae. Using a panel of ELISAs, soluble antigens from lung-stage schistosomula, adult worms, or eggs, were probed with serum s
Predicting risk-reducing occupational AIDS behaviors in a sample of emergency medical personnel.: Percept Mot Skills. 1994 Dec;79(3 Pt 2):1566. Unique Identifier : AIDSLINE MED/95175323; Cooper JS; Zagumny MJ; Department of Psychology, Tennessee Technological University,; Cookeville 38505.
The importance of a single G in the hairpin loop of the iron responsive element (IRE) in ferritin mRNA for structure: an NMR spectroscopy study.: Nucleic Acids Res. 1995 Jan 11;23(1):146-53. Unique Identifier : AIDSLINE MED/95175357; Sierzputowska-Gracz H; McKenzie RA; Theil EC; Department of Biochemistry, North Carolina State University,; Raleigh 27695-7622.; Noncoding sequences regulate the function of mRNA and DNA. In animal mRNAs, iron responsive elements (IREs) regulate the synthesis of proteins for iron storage, uptake and red cell heme formation. Folding of the IRE was indicated previously by reactivity with chemical and enzymatic probes. 1H- and 31P-NMR spectra now
Case-management of AIDS clients as a predictor of total inpatient hospital days.: Public Health Nurs. 1994 Dec;11(6):406-11. Unique Identifier : AIDSLINE MED/95175440; Twyman DM; Libbus MK; Phelps County Health Department, Rolla, Missouri.; AIDS has shifted from an acute short-term terminal illness to a progressive, chronic disorder. Evaluation of AIDS case-management is imperative due to both the increasing numbers of cases and the lengthened survival of those with the disease. In 1988 the Missouri Department of Health (MDOH) initiated the first statewi
School nursing in America--1902-1994: a return to public health nursing.: Public Health Nurs. 1994 Dec;11(6):416-25. Unique Identifier : AIDSLINE MED/95175442; Hawkins JW; Hayes ER; Corliss CP; School of Nursing, Boston College, MA.; In October 1902, Lina Lavanche Rogers began her work in the New York City schools as the first school nurse in the United States . The purpose of this research was to examine the evolution of school nursing as it exemplifies development of a public health nursing specialty. Historiograp
Remembering John [editorial]: Phys Ther. 1995 Mar;75(3):167-8. Unique Identifier : AIDSLINE MED/95175531; Rothstein JM
Photoactive terthiophenes: the influence of serum on anti-HIV (human immunodeficiency virus) activities.: Photochem Photobiol. 1994 Dec;60(6):591-3. Unique Identifier : AIDSLINE MED/95175549; Hudson JB; Marles RJ; Soucy-Breau C; Harris L; Arnason JT; Department of Pathology and Laboratory Medicine, University of; British Columbia, Vancouver, Canada.; A number of carboxylic acid derivatives of the photoactive terthiophene, alpha-terthienyl, were found to possess impressive UVA-dependent activity against the human immunodeficiency virus, HIV-1; but only when assayed in the absence of serum, indicating that the latter contained interfering components. Good antiviral
HIV public policy and psychiatry. An examination of ethical issues and professional guidelines.: Psychosomatics. 1995 Jan-Feb;36(1):12-21. Unique Identifier : AIDSLINE MED/95175922; Daniolos PT; Holmes VF; Consolidated Division of Child and Adolescent Psychiatry,; Cambridge Hospital, Harvard Medical School, MA.; The authors examine the interfaces among public policy, legal issues, ethical issues, and physician responsibility for the human immunodeficiency virus (HIV)-infected psychiatric patient within the realms of civil liberties and public health. Current professional guidelines on caring for HIV-infected psychiatric patie
Differential effects of interleukin-2 and interleukin-7 on the induction of CD4 and CD8 expression by double-negative human thymocytes.: Scand J Immunol. 1995 Mar;41(3):309-12. Unique Identifier : AIDSLINE MED/95176192; He W; Kabelitz D; Institute of Immunology, University of Heidelberg, Germany.; Expression of cell surface CD4 (in the absence of CD3/T cell receptor) characterizes an early stage of intrathymic T cell development. Here, we investigated the appearance of CD4 and CD8 expression on highly purified CD4-8- double-negative human thymocytes in response to interleukin (IL)-7 and
AIDS research priorities [letter; comment] [see comments]: Science. 1995 Mar 3;267(5202):1249. Unique Identifier : AIDSLINE MED/95176211; Kramer L
AIDS research priorities [letter; comment] [published erratum appears in Science 1995 Mar 24;267(5205);1753]: Science. 1995 Mar 3;267(5202):1249-50. Unique Identifier : AIDSLINE MED/95176212; Urnovitz HB; Stevens RW
AIDS: modeling epidemic control [letter; comment]: Science. 1995 Mar 3;267(5202):1250-1; discussion 1252-3. Unique Identifier : AIDSLINE MED/95176213; Longini IM Jr; Halloran ME
AIDS: modeling epidemic control [letter; comment]: Science. 1995 Mar 3;267(5202):1251-2; discussion 1252-3. Unique Identifier : AIDSLINE MED/95176214; Rida W; Fast P; Hoff R; Barker L
Glimmer of hope for T cell booster? [news]: Science. 1995 Mar 3;267(5202):1261. Unique Identifier : AIDSLINE MED/95176216; Cohen J
Factors associated with self-reported STDs: data from a national survey.: Sex Transm Dis. 1994 Nov-Dec;21(6):303-8. Unique Identifier : AIDSLINE MED/95176241; Anderson JE; McCormick L; Fichtner R; Behavioral and Prevention Research Branch, Centers for Disease; Control and Prevention, Atlanta, Georgia 30333.; BACKGROUND AND OBJECTIVES: STD prevention programs need to identify population subgroups and risk behaviors that are associated with higher rates of disease. GOAL OF THE STUDY: To see what levels of STD experience were reported by respondents to a national survey and what factors were associated with self-reported STD
Pattern of sexually transmitted diseases in a Malagasy population.: Sex Transm Dis. 1994 Nov-Dec;21(6):315-20. Unique Identifier : AIDSLINE MED/95176243; Harms G; Matull R; Randrianasolo D; Andriamiadana J; Rasamindrakotroka A; Kirsch T; Hof U; Rarivoharilala E; Korte R; Institut fur Tropenmedizin Berlin, Germany.; BACKGROUND: Data concerning the spectrum and antimicrobial susceptibility of STDs in Madagascar are scarce. OBJECTIVES: Improvement of STD patient management in Madagascar. GOAL OF THE STUDY: Assessment of the spectrum of STDs and improvement of therapy. STUDY DESIGN: Etiologic
HIV infection among female injection-drug users recruited in community settings.: Sex Transm Dis. 1994 Nov-Dec;21(6):321-8. Unique Identifier : AIDSLINE MED/95176244; Watters JK; Estilo MJ; Kral AH; Lorvick JJ; Department of Family and Community medicine, School of Medicine,; University of California, San Francisco.; BACKGROUND AND OBJECTIVES: To identify relationships between sexual behavior, drug use, and HIV infection among female injection-drug users (IDUs) recruited in community settings. STUDY DESIGN: Risk analysis of 407 survey questionnaires and matched HIV serologies (n = 403) from female IDUs recruited from community set
Peptides derived from alpha-helices of allogeneic class I major histocompatibility complex antigens are potent inducers of CD4+ and CD8+ T cell and B cell responses after cardiac allograft rejection.: Transplantation. 1995 Feb 15;59(3):401-10. Unique Identifier : AIDSLINE MED/95176376; Shirwan H; Leamer M; Wang HK; Makowka L; Cramer DV; Department of Surgery, Cedars-Sinai Research Institute,; Cedars-Sinai Medical Center, Los Angeles, California 90048.; We studied the rejection of cardiac allografts in a rat strain combination (PVG.R8 to PVG.1U) disparate for a single class I MHC antigen (RT1.Aa) to test the extent by which this molecule is recognized as peptides in association with recipient MHC molecules during graft rejection and the contribution of this recogniti
Recirculation of cytolytic T cells from a single lymph node during an immune response to allogeneic leukocytes.: Transplantation. 1995 Feb 15;59(3):432-5. Unique Identifier : AIDSLINE MED/95176382; Verhagen AM; Kimpton WG; Nash AD; Centre for Animal Biotechnology, School of Veterinary Science,; University of Melbourne, Parkville, Victoria, Australia.
[Clinical aspects and treatment of herpes virus lesions of the eye in human immunodeficiency virus (HIV) infection]: Vestn Oftalmol. 1994 Oct-Dec;110(4):35-7. Unique Identifier : AIDSLINE MED/95176461; Kasparov AA; Marchenko NR
Characterization of infectious type D retrovirus from baboons.: Virology. 1995 Feb 20;207(1):292-6. Unique Identifier : AIDSLINE GENBANK/U16844; Grant RF; Windsor SK; Malinak CJ; Bartz CR; Sabo A; Benveniste RE; Tsai CC; Regional Primate Research Center, University of Washington,; Seattle 98195.; Infectious virus resembling type D simian retrovirus (SRV) was isolated from Ethiopian baboons (Papio cynocephalus) (SRV-Pc) housed at the University of Washington Regional Primate Research Center. When baboon peripheral blood mononuclear cells (PBMC) or tissues were cocultured with the H-9 human T-cell line or the Ra
Identification of residues in the N-terminal acidic domain of HIV-1 Vpr essential for virion incorporation.: Virology. 1995 Feb 20;207(1):297-302. Unique Identifier : AIDSLINE MED/95176554; Mahalingam S; Khan SA; Jabbar MA; Monken CE; Collman RG; Srinivasan A; Department of Microbiology and Immunology, Thomas Jefferson; University, Philadelphia, Pennsylvania 19107.; Vpr is one of the auxiliary proteins encoded by the HIV-1 genome and is selectively incorporated into the virus particle. It has been shown that Vpr incorporation in the virus particle requires only the core protein Gag. In an effort to identify the domains of Vpr which are essential for incorporation into the HIV-1 v
HIV-1 Nef protein downregulation of CD4 surface expression: relevance of the lck binding domain of CD4.: Virology. 1995 Feb 20;207(1):338-41. Unique Identifier : AIDSLINE MED/95176563; Bandres JC; Shaw AS; Ratner L; Department of Medicine, Washington University School of Medicine,; Saint Louis, Missouri 63110.; HIV Nef protein downregulates the surface expression of CD4 on T-cells but its mechanism of activity is unknown. We have analyzed the relevance of different portions of the CD4 molecule with respect to the activity of Nef. Upon transfection of Jurkat T-cells that express Nef or do not express Nef with constructs that
Dengue fever virus and Japanese encephalitis virus synthetic peptides, with motifs to fit HLA class I haplotypes prevalent in human populations in endemic regions, can be used for application to skin Langerhans cells to prime antiviral CD8+ cytotoxic T cells (CTLs)--a novel approach to the protection of humans.: Virus Genes. 1994 Sep;9(1):33-45. Unique Identifier : AIDSLINE MED/95176572; Becker Y; Department of Molecular Virology, Faculty of Medicine, Hebrew; University of Jerusalem, Israel.; Flaviviruses were reported to induce CD8+ cytotoxic T cells in infected individuals, indicating that nonapeptides, proteolytic cleavage products of the viral precursor protein, enter the endoplasmic reticulum in infected cells and interact with HLA class I molecules. The assembled HLA class I molecules are transported
Successful monochemotherapy of extensive gastrointestinal Kaposi's sarcoma with bowel obstruction in acquired immunodeficiency syndrome.: Z Gastroenterol. 1994 Dec;32(12):688-90. Unique Identifier : AIDSLINE MED/95176677; Lingenfelser T; Daiss W; Overkamp D; Weber P; Department of Medicine, Eberhard-Karls University Tubingen,; Germany.; We report the case history of a 28-year-old homosexual man of Caucasian origin whose diagnosis of acquired immunodeficiency syndrome was established one year before admission on the basis of a positive human immunodeficiency virus serology and cutaneous Kaposi s sarcoma. Severe postprandial vomiting pointed to bowel o
World Health Organization urges sex education in schools to prevent AIDS.: Soz Praventivmed. 1994;39(5):325. Unique Identifier : AIDSLINE MED/95176723
Synthesis of new derivatives of 4-acylquinoxalin-2-ones with potential pharmacological activity.: Acta Pol Pharm. 1994;51(3):231-3. Unique Identifier : AIDSLINE MED/95176841; Mikiciuk-Olasik E; Trzebinski P; Nowak R; Kotelko B; Department of Synthesis and Technology of Drugs, School of; Medicine, Lodz, Poland.; Some of new derivatives of 4-acylquinoxalin-2-one obtained in the reaction of N,N -bis(chloroacetyl)-4,5-dimethyl-o-phenylenediamine with primary amines are described. Compounds were tested for their anti-HIV activity and as ligands for 99mTc.
The Alabama Infected Health Care Worker Act. State Department of Public Health.: Ala Med. 1995 Jan;64(7):14-9. Unique Identifier : AIDSLINE MED/95176997
Alabama Department of Public Health Policy and procedures for compliance with CDC recommendations of July 12, 1991 and Alabama's Infected Health Care Worker Management Act.: Ala Med. 1995 Jan;64(7):20-6. Unique Identifier : AIDSLINE MED/95176999
Pneumatosis cystoides intestinalis and immunosuppression [letter; comment]: Am J Gastroenterol. 1995 Mar;90(3):522-3. Unique Identifier : AIDSLINE MED/95177157; Vincent F; Duboust A; Glotz D
Outcome of severe acute renal failure in patients with acquired immunodeficiency syndrome.: Am J Kidney Dis. 1995 Mar;25(3):390-8. Unique Identifier : AIDSLINE MED/95177163; Rao TK; Friedman EA; Department of Medicine, State University of New York Health; Science Center at Brooklyn.; Among a spectrum of renal disorders encountered in patients infected with the human immunodeficiency virus (HIV), the lesion studied most often has been the glomerular disease known as HIV-associated nephropathy. Of the other coincidental renal perturbations reported, the most significant are a heterogenous group enco
Outcome of polymicrobial peritonitis in continuous ambulatory peritoneal dialysis patients.: Am J Kidney Dis. 1995 Mar;25(3):461-4. Unique Identifier : AIDSLINE MED/95177173; Kiernan L; Finkelstein FO; Kliger AS; Gorban-Brennan N; Juergensen P; Mooraki A; Brown E; Department of Medicine, Hospital of St Raphael, New Haven, CT.; Polymicrobial peritonitis is a relatively uncommon, but potentially serious complication that develops in continuous ambulatory peritoneal dialysis (CAPD) patients. Its cause and optimal management remain controversial. The authors reviewed the frequency and natural history of polymicrobial peritonitis in 432 CAPD pat
Acute pancreatitis in HIV-seropositive patients: a case control study of 44 patients.: Am J Med. 1995 Mar;98(3):243-8. Unique Identifier : AIDSLINE MED/95177188; Cappell MS; Marks M; Department of Medicine, University of Medicine and Dentistry, New; Jersey-Robert Wood Johnson Medical School, New Brunswick; 08903-0019.; PURPOSE: To analyze whether pancreatitis presents differently in HIV-seropositive patients compared to the general population, and to evaluate the accuracy of classic predictors of pancreatitis severity in patients with HIV infection. METHODS: A multiyear, multicenter, retrospective study of 44 consecutive patients wi
Fluconazole in the treatment of chronic pulmonary and nonmeningeal disseminated coccidioidomycosis. NIAID Mycoses Study Group.: Am J Med. 1995 Mar;98(3):249-56. Unique Identifier : AIDSLINE MED/95177189; Catanzaro A; Galgiani JN; Levine BE; Sharkey-Mathis PK; Fierer J; Stevens DA; Chapman SW; Cloud G; Department of Medicine, University of California, San Diego.; PURPOSE: To determine the efficacy and safety of fluconazole as treatment for coccidioidomycosis . PATIENTS AND METHODS: This was a multicenter, open-label, single-arm study. Of 78 patients enrolled, 22 had soft-tissue, 42 had chronic pulmonary, and 14 had skeletal co
Phosphonoformate for CMV retinitis in AIDS [letter; comment]: Am J Med. 1995 Mar;98(3):317-8. Unique Identifier : AIDSLINE MED/95177202; Colucciello M
Foscarnet or ganciclovir for treatment of AIDS and CMV retinitis [letter; comment]: Am J Med. 1995 Mar;98(3):319-20. Unique Identifier : AIDSLINE MED/95177204; Moyle G; Gazzard BG
Deficits in perimetric performance in patients with symptomatic human immunodeficiency virus infection or acquired immunodeficiency syndrome.: Am J Ophthalmol. 1995 Mar;119(3):335-44. Unique Identifier : AIDSLINE MED/95177244; Geier SA; Nohmeier C; Lachenmayr BJ; Klauss V; Goebel FD; Augenklinik Abteilung II und Forschungsstelle fur Experimentelle; Ophthalmologie, Eberhard-Karls-Universitat Tubingen, Germany.; PURPOSE: We measured the perimetric performance in patients with either acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV) disease but without AIDS. METHODS: Light-difference sensitivity in the central field was measured in 74 eyes of 37 patients. The Humphrey Field Analyzer 640, program 3
Pulmonary malignant lymphoma of mucosa-associated lymphoid tissue (MALT) arising in a pediatric HIV-positive patient.: Am J Surg Pathol. 1995 Mar;19(3):357-63. Unique Identifier : AIDSLINE MED/95177288; Teruya-Feldstein J; Temeck BK; Sloas MM; Kingma DW; Raffeld M; Pass HI; Mueller B; Jaffe ES; Laboratory of Pathology, National Cancer Institute, National; Institutes of Health, Bethesda, Maryland 20892.; A malignant lymphoma arising in the lung of a pediatric HIV-positive patient exhibited histologic and clinical features of low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT). Clinically, the neoplasm consisted of a 4-cm mass in the left-upper lobe of the lung of a 7-year-old girl. The lung mass was
Tropical spastic paraparesis on the Caribbean coast of Colombia.: Am J Trop Med Hyg. 1995 Feb;52(2):155-8. Unique Identifier : AIDSLINE MED/95177299; Dangond F; Daza JS; Rosania A; Quin MJ; Zaninovic V; Chaplin B; Marlink R; Hafler DA; Department of Medicine, Brigham and Women's Hospital,; Harvard-Longwood Neurology Training Program, Boston,; Massachusetts.; Tropical spastic paraparesis (TSP) is a retroviral disease characterized predominantly by a chronic myelopathy and progressive leg weakness. Four patients from the northern coast of Columbia with chronic spastic paraparesis and serum positivity for antibodies to human T cell lymphotropic virus type 1 by enzyme-linked
Acute hepatitis, interstitial nephritis, and eosinophilia [letter; comment]: Ann Intern Med. 1995 Apr 1;122(7):555-6. Unique Identifier : AIDSLINE MED/95177455; Hauben M; Adler C
Phytosterols are present in Pneumocystis carinii.: Antimicrob Agents Chemother. 1994 Nov;38(11):2534-40. Unique Identifier : AIDSLINE MED/95177610; Furlong ST; Samia JA; Rose RM; Fishman JA; Department of Medicine, Harvard Medical School, Boston,; Massachusetts.; Although originally classified as a protozoan, Pneumocystis carinii is now considered to have fungal characteristics. Drugs typically used for the treatment of fungal infections target ergosterol. Because P. carinii is an important pathogen in AIDS and other immunocompromised patients, knowledge of the sterol content
In vitro activity of a new antifungal triazole, D0870, against Candida albicans isolates from oral cavities of patients infected with human immunodeficiency virus.: Antimicrob Agents Chemother. 1994 Nov;38(11):2553-6. Unique Identifier : AIDSLINE MED/95177613; Barchiesi F; Colombo AL; McGough DA; Fothergill AW; Rinaldi MG; Department of Pathology, University of Texas Health Science; Center, San Antonio 78284-7750.; We investigated the in vitro activity of a new antifungal triazole, D0870, against 100 Candida albicans isolates from the oral cavities of patients infected with human immunodeficiency virus by using a broth macrodilution method following the recommendations provided by the National Committee for Clinical Laboratory S
Predictive marker for the development of cerebral toxoplasmosis in patients with human immunodeficiency virus type 1 [letter]: Arch Neurol. 1995 Mar;52(3):229. Unique Identifier : AIDSLINE MED/95177743; Rolfs A; Schaub R
Exaggerated messenger RNA expression of inflammatory cytokines in human T-cell lymphotropic virus type I-associated myelopathy.: Arch Neurol. 1995 Mar;52(3):276-80. Unique Identifier : AIDSLINE MED/95177754; Watanabe H; Nakamura T; Nagasato K; Shirabe S; Ohishi K; Ichinose K; Nishiura Y; Chiyoda S; Tsujihata M; Nagataki S; First Department of Internal Medicine, Nagasaki, Japan.; OBJECTIVE: To investigate the expression of inflammatory cytokine messenger RNA (mRNA) in peripheral blood mononuclear cells of patients with human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM). PATIENTS: Seventeen patients with HAM, 18 HTLV-I-seropositive carriers, and 10 seronegative individu
AIDS and the neurosurgeon--an update.: Adv Tech Stand Neurosurg. 1994;21:155-82. Unique Identifier : AIDSLINE MED/95177841; Ciricillo SF; Rosenblum ML; Department of Neurological Surgery, School of Medicine,; University of California, San Francisco.; Over the past decade, acquired immunodeficiency syndrome (AIDS) has become the leading public health crisis in the United States , Western Europe, and Africa. Despite improvements in the diagnosis and treatment of AIDS-related disorders, the number of people infected with the human immu
Immunoregulation in allergy: the potential of anti-IgE antibodies of IL-4 antagonists for the treatment of allergic diseases.: Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M. 1994;(87):283-9; discussion 289-91. Unique Identifier : AIDSLINE MED/95177943; Heusser C; Ciba-Geigy Ltd., Basel, Switzerland.; IL-4 plays a crucial role in the induction of allergic responses, not only in inducing the switch of B cells to the production of IgE antibodies but also in promoting the differentiation of T cells to the TH2 phenotype leading to the production of IL-4 and IL-5. Initially, IL-4 may be provided by basophils and/or mast
Cardiac morbidity in the human immunodeficiency virus infection.: Rev Port Cardiol. 1994 Dec;13(12):901-11. Unique Identifier : AIDSLINE MED/95178145; Cardoso JS; Miranda AM; Moura B; Gomes MH; Oliveira P; Conde C; Cruz A; Puig J; Bartolomeu J; Martins L; et al; Hospitalar de Cardiologia do Hospital de S. Joao e Assistente da; Faculdade de Medicina do Porto.; PURPOSE: To evaluate the cardiac involvement in Human Immunodeficiency Virus (HIV) infection. DESIGN: Prospective and normal individuals group controlled study. SETTING: The departments of cardiology and infectious diseases of an university hospital. PATIENTS: 137 consecutive HIV infected patients at all stages of the
The current global situation of the HIV/AIDS pandemic.: Wkly Epidemiol Rec. 1995 Jan 13;70(2):7-8. Unique Identifier : AIDSLINE MED/95178272
Clinical applications of magnetic resonance spectroscopy.: Magn Reson Q. 1994 Dec;10(4):191-247. Unique Identifier : AIDSLINE MED/95178281; Ross B; Michaelis T; Clinical Magnetic Resonance Spectroscopy Unit, Huntington Medical; Research Institutes, Pasadena, California 91105.; Neurospectroscopy measures a neuronal marker, energy and redox state, specific fuels of tissue respiration, maturation, and possibly myelination. It provides diagnostic patterns of altered neurochemistry. Current clinical uses range from intensive care in neonates to dementia in th
Efficacy of an analysis of lymphocyte subsets in predicting the clinical response to alpha-interferon therapy in thalassaemia patients with chronic infection by hepatitis C virus: a pilot study.: Br J Haematol. 1995 Feb;89(2):291-8. Unique Identifier : AIDSLINE MED/95178308; Russo-Mancuso G; Di Gregorio F; Passero E; Sciotto A; Mazzarino MC; Malaponte G; Schiliro G; Division of Paediatric Haematology/Oncology, University of; Catania, Italy.; alpha-interferon (alpha-IFN) has been used to treat chronic non-A non-B hepatitis in thalassaemic patients with response rates from 45% to 83%. Unfortunately, treatment with alpha-IFN is associated with side-effects which have a negative effect on the quality of life of the patient. Therefore it would be useful if we
[Cultivation and activation of Th1 and Th2 clones]: Hum Cell. 1994 Sep;7(3):125-30. Unique Identifier : AIDSLINE MED/95178435; Nariuchi H; Department of allergology, Institute of Medical Science,; University of Tokyo, Japan.; Murine T helper clones are classified into two subpopulations, Th1 and Th2, according to the cytokines they produce. Immune function is considered to depend which subpopulation is activated by an antigen stimulation. These subpopulations are different from each other in humoral second signal molecules required for the
[An efficient methods for the induction of human antitumor effector CD4+ and CD8+ T cells: their application to tumor immunotherapy]: Hum Cell. 1994 Sep;7(3):131-7. Unique Identifier : AIDSLINE MED/95178436; Nishimura T; Kuge S; Watanabe K; Lee U; Yahata T; Habu S; Department of Immunology, Tokai University School of Medicine,; Isehara, Japan.; It is an important issues to investigate an efficient methods to induce antitumor effector T cells from peripheral blood lymphocytes of tumor patients for the development of a novel tumor immunotherapy. We established a large scale culture system of human CD4+ helper/killer T cells which have both helper and killer fu
Molluscum contagiosum mimicking sebaceous nevus of Jadassohn, ecthyma and giant condylomata acuminata in HIV-infected patients.: Dermatology. 1994;189(4):396-8. Unique Identifier : AIDSLINE MED/95178784; Itin PH; Gilli L; Department of Dermatology, University of Basel, Switzerland.; We report on three HIV-infected homosexual male patients with atypical manifestations of mollusca contagiosa (MC). Their clinical presentation mimicked sebaceous nevus of Jadassohn, ecthyma and giant condylomata acuminata. HIV-infected patients feature MC with atypical morphology in about two thirds of the cases. The
[Safety from HIV infection of preserved blood from Germany (editorial; comment)]: Infusionsther Transfusionsmed. 1994 Dec;21(6):360-1. Unique Identifier : AIDSLINE MED/95178877; Gurtler L; Munchen
[A retrospective study of the practice of look-back procedures, on the incidence of HIV-1/2-positive blood donors and the risk of transfusion-associated HIV infection in public-community blood banks in Germany (see comments)]: Infusionsther Transfusionsmed. 1994 Dec;21(6):362-7. Unique Identifier : AIDSLINE MED/95178878; Zeiler T; Kretschmer V; Sibrowski W; Abteilung fur Transfusionsmedizin und Gerinnungsphysiologie,; Philipps-Universitat Marburg.; OBJECTIVE: Look-back investigations can reveal and confirm transfusion-transmitted infectious diseases and provide data for risk calculations of blood transfusions. DESIGN: In 1993 we distributed a questionnaire to all governmental and communal blood transfusion services in Germany
[HIV retrospective study of the German Red Cross blood donation service in Germany (see comments)]: Infusionsther Transfusionsmed. 1994 Dec;21(6):368-75. Unique Identifier : AIDSLINE MED/95178879; Gluck D; Elbert G; Dengler T; Gossrau E; Grassmann W; Grimm M; Holzberger G; Sternberger J; Weise W; Kubanek B; Abteilung Transfusionsmedizin, Universitat und; DRK-Blutspendezentrale Ulm.; OBJECTIVE: It was tried to retrospectively identify HIV infections in recipients of transfusions from donors who were tested HIV positive at a subsequent donation. These lookback data were traced back to answer the following questions: 1. How many transfusion recipients were infected before the start of the routine HI
The monomeric and dimeric mannose-binding proteins from the Orchidaceae species Listera ovata and Epipactis helleborine: sequence homologies and differences in biological activities.: Glycoconj J. 1994 Aug;11(4):321-32. Unique Identifier : AIDSLINE GENBANK/U07787; Van Damme EJ; Balzarini J; Smeets K; Van Leuven F; Peumans WJ; Laboratory for Phytopathology and Plant Protection, Katholieke; Universiteit Leuven, Belgium.; The Orchidaceae species Listera ovata and Epipactis helleborine contain two types of mannose-binding proteins. Using a combination of affinity chromatography on mannose-Sepharose-4B and ion exchange chromatography on a Mono-S column eight different mannose-binding proteins were isolated from the leaves of Listera ovat
Recognizing the patient at risk for opportunistic infections.: Medsurg Nurs. 1994 Dec;3(6):445-52. Unique Identifier : AIDSLINE MED/95179213; Hedges CB; Advances in the treatment of many chronic and end-stage diseases as well as the emergence of AIDS has yielded an immunocompromised patient population. Nurses caring for these patients must be aware of their potential for developing deadly opportunistic infections. By identifying the patient at risk, nurses hope to del
HIV-1 envelope protein gp120 potentiates NMDA-evoked noradrenaline release by a direct action at rat hippocampal and cortical noradrenergic nerve endings.: Eur J Neurosci. 1994 Nov 1;6(11):1743-9. Unique Identifier : AIDSLINE MED/95179325; Pittaluga A; Raiteri M; Istituto di Farmacologia e Farmacognosia, Genova, Italy.; Exposure of rat or human neocortical or hippocampal tissue to glutamate receptor agonists elicits as Ca(2+)-dependent, exocytotic-like release of previously accumulated [3H]noradrenaline through activation of both N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors
T cells, cytokines, IgE and allergic airways inflammation.: J Investig Allergol Clin Immunol. 1994 Sep-Oct;4(5):214-20. Unique Identifier : AIDSLINE MED/95179329; Ricci M; Matucci A; Rossi O; Istituto di Clinica Medica III, University of Florence, Italy.; Great progress in the knowledge of the cellular and molecular signals involved in IgE antibody synthesis and in the induction of allergic inflammation has been achieved. A great deal of data support the view that Th-2-like cells are the main type of cells required for IgE production and are able to orchestrate allergi
General operative aspects of human immunodeficiency virus infection and acquired immunodeficiency syndrome.: J Am Coll Surg. 1995 Mar;180(3):366-80. Unique Identifier : AIDSLINE MED/95179365; Consten EC; van Lanschot JJ; Henny CP; Slors JF; Danner SA; Brummelkamp WH; Department of Surgery, Academic Medical Center, Amsterdam, The; Netherlands.
Neuro-AIDS. Proceedings of a workshop. Portland, Maine, August 16-19, 1993.: Adv Neuroimmunol. 1994;4(3):145-336. Unique Identifier : AIDSLINE MED/95179401
Summary of workshop contributions.Third Workshop on NeuroAIDS.: Adv Neuroimmunol. 1994;4(3):149-56. Unique Identifier : AIDSLINE MED/95179402; Black R; Sager P; National Institute of Allergy and Infectious Diseases, NIH,; Rockville, MD 20892.
gp120 as an etiologic agent for NeuroAIDS: neurotoxicity and model systems.: Adv Neuroimmunol. 1994;4(3):157-65. Unique Identifier : AIDSLINE MED/95179403; Brenneman DE; McCune SK; Mervis RF; Hill JM; Section on Developmental and Molecular Pharmacology, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, MD 20892.; The search for an agent that can mediate the symptoms of NeuroAIDS has been directed at gp120, the major envelope protein from HIV. The toxicity associated with gp120 was examined as a model and predictor of the neuropathological and neuropsychiatric manifestations of AIDS. Studies of the neurotoxic effects of purifie
gp120-mediated alterations in astrocyte ion transport.: Adv Neuroimmunol. 1994;4(3):175-9. Unique Identifier : AIDSLINE MED/95179405; Benos DJ; Hahn BH; Shaw GM; Bubien JK; Benveniste EN; Department of Physiology and Biophysics, University of Alabama at; Birmingham 35294.; The pathogenesis of the acquired immunodeficiency syndrome (AIDS) dementia complex (ADC) is unknown. However, recent work indicates that neurons and astrocytes are functionally compromised by exposure to viral components or cellular factors released from HIV-1-infected macrophages/
Update on current models of HIV-related neuronal injury: platelet-activating factor, arachidonic acid and nitric oxide.: Adv Neuroimmunol. 1994;4(3):181-8. Unique Identifier : AIDSLINE MED/95179406; Lipton SA; Yeh M; Dreyer EB; Department of Neurology, Children's Hospital, Boston, MA.; This review aims to summarize recent work related to the pathogenesis and possible treatment of neuronal injury in the acquired immunodeficiency syndrome (AIDS), especially with reference to potential neurotoxic substances released by HIV-infected or gp120-stimulated macrophages/microglia. Approximately a third of adu
An experimental model system for HIV-1-induced brain injury.: Adv Neuroimmunol. 1994;4(3):189-93. Unique Identifier : AIDSLINE MED/95179407; Gendelman HE; Genis P; Jett M; Zhai QH; Nottet HS; Department of Medicine, University of Nebraska Medical Center,; Omaha 68198.; The pathological hallmark of HIV infection in brain is productive viral replication in cells of mononuclear phagocyte lineage including brain macrophages, microglia and multinucleated giant cells (Koenig et al., 1986; Wiley et al., 1986; Gabuzda et al., 1986; Stoler et al., 1986). These cells secrete viral and cell en
Investigation of HIV-infected macrophage neurotoxin production from patients with AIDS dementia.: Adv Neuroimmunol. 1994;4(3):195-8. Unique Identifier : AIDSLINE MED/95179408; Pulliam L; Clarke JA; McGuire D; McGrath MS; Department of Laboratory Medicine, University of California, San; Francisco.; The mechanism for AIDS dementia may involve the production of toxic cytokines. Since macrophage/microglia are the infected cells in the brain, we were interested in the production of some of the same cytokines by HIV-infected macrophages from patients with AIDS dementia. HIV-infect
Cytokine dysregulation in HIV-associated neurological disease.: Adv Neuroimmunol. 1994;4(3):199-206. Unique Identifier : AIDSLINE MED/95179409; Wesselingh SL; Glass J; McArthur JC; Griffin JW; Griffin DE; Department of Microbiology and Infectious Diseases, Flinders; University of South Australia, Adelaide.; AIDS is associated with three major neurological syndromes: dementia (HIVD), vacuolar myelopathy (VM) and plainful sensory neuropathy (PSN). The pathogenesis of these conditions remains unclear although they all demonstrate a marked increase in macrophage number and activation desp
Clinical comparison of adult and pediatric NeuroAIDS.: Adv Neuroimmunol. 1994;4(3):207-21. Unique Identifier : AIDSLINE MED/95179410; Mintz M; Division of Pediatric Neurology, Cooper Hospital/University; Medical Center, Camden, New Jersey 08103.; Human Immunodeficiency Virus type-1 (HIV-1)-associated neurologic disease occurs as the initial presenting clinical manifestation of acquired immunodeficiency syndrome (AIDS) in 3-7% of infected patients, but in up to 18% of children and adolescents (Janssen, 1992; Janssen et al., 1992; Scott et al., 1989; Mintz et al
Interrelations among patterns of change in neurocognitive, CT brain imaging and CD4 measures associated with anti-retroviral therapy in children with symptomatic HIV infection.: Adv Neuroimmunol. 1994;4(3):223-31. Unique Identifier : AIDSLINE MED/95179411; Brouwers P; DeCarli C; Tudor-Williams G; Civitello L; Moss H; Pizzo P; Pediatric Branch, National Cancer Institute, Bethesda, MD 20892.; The interrelationships of patterns of change and variability between baseline and after 6 months of anti-retroviral therapy in neurocognitive, brain imaging, and immune measures were studied in 77 children with symptomatic HIV disease. Overall improvement in CNS structure/function after 6 months of anti-retroviral the
Effects of chronic zidovudine administration on CNS function and virus burden after perinatal SIV infection in rhesus monkeys.: Adv Neuroimmunol. 1994;4(3):233-7. Unique Identifier : AIDSLINE MED/95179412; Rausch DM; Heyes M; Eiden LE; Section on Molecular Neuroscience, National Institute of Mental; Health, National Institutes of Health, Bethesda, MD.; Continuous intravenous administration of zidovudine ( AZT ) has been reported to improve cognitive function in HIV-infected pediatric patients (Pizzo et al., 1988). The effects of long-term zidovudine treatment in the perinatally infected pediatric popu
Human neural xenografts: progress in developing an in-vivo model to study human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV) infection.: Adv Neuroimmunol. 1994;4(3):257-60. Unique Identifier : AIDSLINE MED/95179415; Epstein LG; Cvetkovich TA; Lazar ES; DiLoreto D; Saito Y; James H; del Cerro C; Kaneshima H; McCune JM; Britt WJ; et al; Department of Neurology, University of Rochester Division of; Child Neurology, NY 14642.; Human immunodeficiency virus type 1 (HIV-1) infection is highly specific for its human host. In order to study HIV-1 infection of the human nervous system, we have established a small animal model in which second-trimester (11-17.5 weeks) human fetal brain or neural retina is transplanted into the anterior chamber of
In vivo model of HIV infection of the human brain.: Adv Neuroimmunol. 1994;4(3):261-4. Unique Identifier : AIDSLINE MED/95179416; Achim CL; Wiley CA; University of Pittsburgh Medical Center, Department of Pathology,; PA 15213-2582.; Approximately one quarter of AIDS patients develop neurologic symptoms attributable to HIV infection within the brain. Previous studies suggest that HIV associated neurologic damage may be mediated by immune factors secreted by activated/infected CNS macrophages. We developed an in vivo system in which human embryonic
Neuronal substrates for SIV encephalopathy.: Adv Neuroimmunol. 1994;4(3):265-71. Unique Identifier : AIDSLINE MED/95179417; da Cunha A; Eiden LE; Rausch DM; Section on Molecular Neuroscience, National Institute of Mental; Health, National Institutes of Health, Bethesda, MD.; Prior to the onset of immunodeficiency disease, neurochemical and neuropathological events associated with motor and/or cognitive impairment can be identified in rhesus monkeys infected with simian immunodeficiency virus (SIV). These are astrocytosis, up-regulation of mRNA encoding the neuropeptide somatostatin (SRIF)
Immune regulatory and effector properties of human adult microglia studies in vitro and in situ.: Adv Neuroimmunol. 1994;4(3):273-81. Unique Identifier : AIDSLINE MED/95179418; Williams K; Ulvestad E; Antel J; Department of Neurology and Neurosurgery, Montreal Neurological; Institute, McGill University, Canada.; Monocytes, macrophages, and brain microglia are the primary cell types most readily demonstrated to be infected in CNS lesions of patients infected with HIV (Koenig et al., 1986). Microglia are implicated in mediating CNS immune regulation and neural tissue injury associated with the AIDS-
Detection of HIV-1 DNA in pediatric AIDS brain tissue by two-step ISPCR.: Adv Neuroimmunol. 1994;4(3):283-5. Unique Identifier : AIDSLINE MED/95179419; Sharer LR; Saito Y; Epstein LG; Blumberg BM; Department of Pathology, New Jersey Medical School, Newark.; In order to detect latent infection in neurons or other cell types in formalin-fixed brain tissue, we performed polymerase chain reaction amplification with incorporation of digoxigenin-conjugated deoxynucleotides, followed by in situ hybridization with biotinylated probes. The use of this two-step technique in brain
In vivo and in vitro infection of the astrocyte by HIV-1.: Adv Neuroimmunol. 1994;4(3):287-9. Unique Identifier : AIDSLINE MED/95179420; Conant K; Tornatore C; Atwood W; Meyers K; Traub R; Major EO; Laboratory of Molecular Medicine and Neuroscience, National; Institutes of Health, Bethesda, MD 20892.
Activation of HIV-1 transcription by Tat in cells derived from the CNS: evidence for the participation of NF-kappa B--a review.: Adv Neuroimmunol. 1994;4(3):291-303. Unique Identifier : AIDSLINE MED/95179421; Taylor JP; Khalili K; Molecular Neurovirology Section, Jefferson Institute of Molecular; Medicine, Philadelphia, PA.; Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of acquired immune deficiency syndrome (AIDS). The Tat protein of HIV-1 is a potent activator of transcription directed by the viral long terminal repeat. It has been widely reported that this activation requires a specific interaction between Tat and
Neuroglial-specific factors and the regulation of retrovirus transcription.: Adv Neuroimmunol. 1994;4(3):305-18. Unique Identifier : AIDSLINE MED/95179422; Tillmann M; Krebs FC; Wessner R; Pomeroy SM; Goodenow MM; Wigdahl B; Department of Microbiology and Immunology, Pennsylvania State; University, College of Medicine, Hershey 17033.; Retroviruses have been implicated as causative agents of a variety of human diseases including malignancy, immune system dysfunction, and neurologic disorders. Despite the isolation of various retroviral agents from patients suffering from malignant neoplasias and neurologic disorders, only the human T-cell lymphotrop
Measurement of CNS HIV burden and its association with neurologic damage.: Adv Neuroimmunol. 1994;4(3):319-25. Unique Identifier : AIDSLINE MED/95179423; Wiley CA; Masliah E; Achim CL; University of Pittsburgh Medical Center, Department of Pathology,; PA 15213-2582.; AIDS dementia complex affects between 20 and 30% of terminally ill AIDS patients. The histopathologic substrate of this clinical syndrome is chronic HIV infection of the nervous system termed HIV encephalitis. We hypothesize that the abundance and length of time that HIV is present
CMV-specific immune responses and HLA phenotypes of AIDS patients who develop CMV retinitis. HNRC Group. HIV Neurobehavioral Research Center.: Adv Neuroimmunol. 1994;4(3):327-36. Unique Identifier : AIDSLINE MED/95179424; Schrier RD; Freeman WR; Wiley CA; McCutchan JA; Department of Pathology, University of California, San Diego, La; Jolla 92093.; HLA phenotype and immune responses to CMV were studied to determine whether the subset of AIDS patients who developed CMV retinitis were immunogenetically or immunologically predisposed. CMV retinitis develops in approximately 28-35% of AIDS patients and CMV enc
[A KABP (knowledge, attitude, belief and behavior) study about AIDS among taxi drivers and hotel attendants in Beijing]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1994 Dec;15(6):323-7. Unique Identifier : AIDSLINE MED/95179755; Zhang X; Luo B; Zhang K; Department of Epidemiology, Peking Union Medical University,; Beijing.; This article reports the KABP study on 448 taxi drivers and 556 hotel attendants in Beijing for the first time in China . A self-administered questionnaire was used to investigate knowledge, attitude, belief and practice (KABP) about AIDS. In terms of knowledge, 23.8% of hotel attend
MluI site-dependent transcriptional regulation of the Candida albicans dUTPase gene [published erratum appears in Curr Genet 1995 Apr;27(5):491]: Curr Genet. 1994 Nov-Dec;26(5-6):415-21. Unique Identifier : AIDSLINE GENBANK/X77925; McIntosh EM; Looser J; Haynes RH; Pearlman RE; Department of Biology, University of York, Toronto, Ontario,; Canada.; The Candida albicans dUTP pyrophosphatase (dUTPase) gene DUT1 has been isolated by genetic complementation in S. cerevisiae. It was found to encode a 17-kDa protein similar in amino-acid sequence to dUTPases isolated from other systems. The gene was adapted for expression in E. coli and yielded a soluble and highly-ac
[An immunohistochemical study of Ki-67 expression of brain tumor cells and mononuclear cell subsets infiltrating these tumors]: Chung-hua Ping Li Hsueh Tsa Chih. 1994 Oct;23(5):267-9. Unique Identifier : AIDSLINE MED/95179821; Yu SZ; Zhang JQ; Lu GH; Department of Neuropathology, Tianjin Medical College Hospital.; Fifty-one brain tumors were studied by immunohistochemical methods. The densities of CD45RO+, CD4(OPD4) and CD8 T cells infiltrating the tumors showed negative correlation with the tumor size and positive correlation with the density of macrophages. The density of Ki-67+ tumor cells rose along with the increase in tum
Prominent gallium uptake associated with silicone implants in an asymptomatic patient.: Clin Nucl Med. 1994 Dec;19(12):1107-8. Unique Identifier : AIDSLINE MED/95179886; Decorato D; Derogatis AJ; Department of Radiology, St. Luke's Roosevelt Hospital Center,; New York, New York 10019.
Diagnostic significance of Tl-201-Ga-67 discordant pattern of biodistribution in AIDS.: Clin Nucl Med. 1994 Dec;19(12):1117-8. Unique Identifier : AIDSLINE MED/95179891; Getz JM; Bekerman C; Department of Diagnostic Radiology, Michael Reese Hospital and; Medical Center, Chicago, Illinois 60616.
Associating poor outcome with the presence of cytomegalovirus in bronchoalveolar lavage from HIV patients with Pneumocystis carinii pneumonia [editorial; comment]: Chest. 1995 Mar;107(3):595-7. Unique Identifier : AIDSLINE MED/95179996; Hyland M; Chan M; Hyland RH; Chan CK
The relationship between cytomegalovirus retrieved by bronchoalveolar lavage and mortality in patients with HIV [see comments]: Chest. 1995 Mar;107(3):735-40. Unique Identifier : AIDSLINE MED/95180021; Hayner CE; Baughman RP; Linnemann CC Jr; Dohn MN; Department of Internal Medicine, University of Cincinnati Medical; Center, OH 45267-0564.; STUDY OBJECTIVE: To evaluate mortality over 6 months of patients with HIV with cytomegalovirus ( CMV ) cultured from bronchoalveolar lavage (BAL) compared with those without CMV and to assess the significance of CMV cytologic s
Potential role of cytokines in disseminated mycobacterial infections.: Eur J Clin Microbiol Infect Dis. 1994;13 Suppl 2:S29-33. Unique Identifier : AIDSLINE MED/95180237; Bermudez LE; Kuzell Institute for Arthritis and Infectious Diseases, San; Francisco, California 94115.; Organisms belonging to the Mycobacterium avium complex (MAC) are common pathogens in immunosuppressed and AIDS patients. This paper reviews the role of cytokines in the pathogenesis of MAC infection. MAC organisms mainly infect monocytes and macrophages, and the effect of HIV infection on susceptibility of macrophages
Combination of ganciclovir and granulocyte-macrophage colony-stimulating factor in the treatment of cytomegalovirus retinitis in AIDS patients. The ACTG 073 Team.: Eur J Clin Microbiol Infect Dis. 1994;13 Suppl 2:S34-40. Unique Identifier : AIDSLINE MED/95180239; Hardy D; Spector S; Polsky B; Crumpacker C; van der Horst C; Holland G; Freeman W; Heinemann MH; Sharuk G; Klystra J; et al; AIDS Clinical Research Center, University of California, Los; Angeles 90024-1793.; The efficacy and safety of a combination of ganciclovir plus GM-CSF was evaluated in AIDS patients with cytomegalovirus retinitis. In phase A, patients were randomized to receive ganciclovir, 5 mg/kg every 12 h for 14 days followed by 5 mg/kg daily, with (n = 24) or without (n = 29
Immune response to Mycobacterium bovis bacille Calmette Guerin infection in major histocompatibility complex class I- and II-deficient knock-out mice: contribution of CD4 and CD8 T cells to acquired resistance.: Eur J Immunol. 1995 Feb;25(2):377-84. Unique Identifier : AIDSLINE MED/95180293; Ladel CH; Daugelat S; Kaufmann SH; Department of Immunology, University of Ulm, Germany.; Knock-out mice with defined major histocompatibility complex (MHC) deficiencies were infected intravenously with Mycobacterium bovis bacille Calmette Guerin (M. bovis BCG) to assess the relative impact of MHC class I- and II-dependent immune responses. Heterozygous control mice were capable of controlling growth of M.
CD28 activation promotes Th2 subset differentiation by human CD4+ cells.: Eur J Immunol. 1995 Feb;25(2):587-95. Unique Identifier : AIDSLINE MED/95180324; King CL; Stupi RJ; Craighead N; June CH; Thyphronitis G; Division of Geographic Medicine, Case Western Reserve University,; Cleveland, OH 44106-4983.; Ligation of CD28 provides a costimulatory signal to T cells necessary for their activation resulting in increased interleukin (IL)-2 production in vitro, but its role in IL-4 and other cytokine production and functional differentiation of T helper (Th) cells remains uncertain. We studied the pattern of cytokine produc
Herpes simplex virus tracheitis in a patient with the acquired immunodeficiency syndrome.: Eur Respir J. 1994 Nov;7(11):2091-3. Unique Identifier : AIDSLINE MED/95180403; Baras L; Farber CM; Van Vooren JP; Parent D; Dept of Dermatology, Universite Libre de Bruxelles, Erasme; Hospital, Belgium.; Herpetic tracheobronchitis and pneumonia occur basically in immunodepressed patients, but have rarely been reported in patients with the acquired immunodeficiency syndrome (AIDS). Some large reviews on pulmonary manifestations in AIDS report a small number of herpetic pulmonary infections, without determining any prev
The non-steroidal anti-inflammatory drug, indomethacin, as an inhibitor of HIV replication.: FEBS Lett. 1995 Feb 20;360(1):85-8. Unique Identifier : AIDSLINE MED/95180424; Bourinbaiar AS; Lee-Huang S; Department of Biochemistry, New York University Medical Center,; NY 10016.; Indomethacin, a common non-steroidal anti-inflammatory drug (NSAID), has been used to treat rheumatoid arthritis. Although indomethacin has also been used as an immunopotentiator and symptomatic NSAID in AIDS, its effect on HIV replication is unknown. MT-4 lymphocytes were inoculated with HIV in the presence of indome
[Acute toxoplasmic pancreatitis. An unusual cause of death in AIDS]: Gastroenterol Clin Biol. 1994;18(10):895-7. Unique Identifier : AIDSLINE MED/95180519; Hofman P; Michiels JF; Mondain V; Saint-Paul MC; Rampal A; Loubiere R; Service d'Anatomo-Pathologie, Hopital Pasteur, Nice.; We report a case of an acute toxoplasmic pancreatitis that led to the death of an AIDS patient. Aetiological diagnosis was performed by the post mortem histological examination. On haematein-eosin staining, toxoplasmic cysts and pseudocysts were noted in the pancreatic acini. Immunohistochemical study using anti-Toxop
Inefficacy of intestinal secretory immune response to Cryptosporidium in acquired immunodeficiency syndrome.: Gastroenterology. 1995 Mar;108(3):627-35. Unique Identifier : AIDSLINE MED/95180589; Benhamou Y; Kapel N; Hoang C; Matta H; Meillet D; Magne D; Raphael M; Gentilini M; Opolon P; Gobert JG; Service d'Hepato-Gastroenterologie, Groupe Hospitalier; Pitie-Salpetriere, Paris, France.; BACKGROUND/AIMS: An alteration of the secretory immune response has been forwarded to explain frequent and chronic mucosal infections in patients with acquired immunodeficiency syndrome (AIDS). The aim of this study was to explore the intestinal immunoglobulin (Ig) secretions in patients with AIDS and their relationsh
Orthotopic liver transplantation for chronic hepatitis in two patients with common variable immunodeficiency.: Gastroenterology. 1995 Mar;108(3):879-84. Unique Identifier : AIDSLINE MED/95180620; Smith MS; Webster AD; Dhillon AP; Dusheiko G; Boulton R; Savage K; Rolles K; Burroughs AK; University Department of Medicine, Royal Free Hospital, London,; England.; Two patients with common variable immunodeficiency underwent orthotopic liver transplantation for chronic hepatitis, unequivocally caused by hepatitis C virus in one case. Although one patient had pneumonia 8 days after surgery and the other developed hepatic venular stenosis in the transplanted liver, both had a reas
Mammalian cell/vaccinia virus expression vectors with increased stability of retroviral sequences in Escherichia coli: production of feline immunodeficiency virus envelope protein.: Gene. 1995 Feb 14;153(2):197-202. Unique Identifier : AIDSLINE MED/95180718; Wang RF; Mullins JI; Department of Microbiology and Immunology, Stanford University; School of Medicine, CA 94305-5402.; Many eukaryotic DNA sequences, especially lenti-retrovirus proviral genomes and their env genes, are unstable when cloned in high-copy-number plasmids in Escherichia coli. Stability can be increased by the use of low-copy-number vectors, although plasmid yields are low. Vectors are described here that contain the inte
Conditional immortalization of Gunn rat hepatocytes: an ex vivo model for evaluating methods for bilirubin-UDP-glucuronosyltransferase gene transfer.: Hepatology. 1995 Mar;21(3):837-46. Unique Identifier : AIDSLINE MED/95180848; Fox IJ; Chowdhury NR; Gupta S; Kondapalli R; Schilsky ML; Stockert RJ; Chowdhury JR; Department of Surgery, University of Nebraska Medical Center,; Omaha.; Viral vectors and protein carriers utilizing asialoglycoprotein receptor (ASGR)-mediated endocytosis are being developed to transfer genes for the correction of bilirubin-UDP-glucuronosyltransferase (bilirubin-UGT) deficiency. Ex vivo evaluation of these gene transfer vectors would be facilitated by a cell system that
Effect of IFN-gamma on the proliferation of Toxoplasma gondii in monocytes and monocyte-derived macrophages from AIDS patients.: Immunology. 1994 Dec;83(4):646-50. Unique Identifier : AIDSLINE MED/95180921; Delemarre FG; Stevenhagen A; Kroon FP; van Eer MY; Meenhorst PL; van Furth R; Department of Infectious Diseases, University Hospital, Leiden,; The Netherlands.; This study was undertaken to determine whether the activity of monocytes and monocyte-derived macrophages (MDM) from acquired immune deficiency syndrome (AIDS) patients against Toxoplasma gondii is altered and whether this activity can be modulated by recombinant interferon-gamma (rIFN-gamma). Untreated and rIFN-gamma
Recombinant L7/L12 ribosomal protein and gamma-irradiated Brucella abortus induce a T-helper 1 subset response from murine CD4+ T cells.: Immunology. 1994 Dec;83(4):659-64. Unique Identifier : AIDSLINE MED/95180923; Oliveira SC; Zhu Y; Splitter GA; Department of Animal Health and Biomedical Sciences, University; of Wisconsin-Madison 53706.; Immunity to Brucella abortus crucially depends on antigen (Ag)-specific T-cell mediated activation of macrophages, which are the major effectors of cell-mediated killing of this organism. Ribosomal preparations have been used as vaccines against several pathogens, including B. abortus, conferring a high degree of prot
Antigen expressed by Salmonella typhimurium is processed for class I major histocompatibility complex presentation by macrophages but not infected epithelial cells.: Immunology. 1994 Dec;83(4):670-4. Unique Identifier : AIDSLINE MED/95180925; Harding CV; Pfeifer JD; Institute of Pathology, Case Western Reserve University,; Cleveland, Ohio 44106.; Macrophages were shown to mediate class I major histocompatibility complex (MHC-1) presentation of a fusion protein (Crl-OVA) expressed in Salmonella typhimurium, a bacterium which fails to escape from vacuolar compartments after phagocytosis or penetration into host cells. Salmonella typhimurium also penetrates into
HIV related immune thrombocytopenia.: Indian Pediatr. 1994 Feb;31(2):204-7. Unique Identifier : AIDSLINE MED/95181031; Godambe SV; Jayakar AV; Muzumdar HV; Kandoth PW; Department of Pediatrics, Topiwala National Medical College,; Bombay.
Migrant sensory neuritis associated with AIDS: case report.: Ital J Neurol Sci. 1994 Nov;15(8):433-6. Unique Identifier : AIDSLINE MED/95181147; Pavesi G; Medici D; Lusvardi M; Gemignani F; Macaluso GM; Magnani G; Mancia D; Istituto di Neurologia, Universita di Parma.; We studied an AIDS patient who suffered from numbness, paresthesias and pain in the territories of different non-contiguous cutaneous nerves at different times. A transitory partial loss of touch and pinprick sensibility was also present in the same cutaneous areas. Sensory conduction velocities and SAP amplitudes wer
[Risk and prevention of HIV infection in the operating room]: Helv Chir Acta. 1994 Dec;60(6):1021-3. Unique Identifier : AIDSLINE MED/95181166; Iten A; Division autonome de medecine preventive hospitaliere, CHUV,; Lausanne.
Successful use of CAPD as ESRD therapy in a HIV positive patient.: J Assoc Physicians India. 1994 Oct;42(10):828-9. Unique Identifier : AIDSLINE MED/95181269; Abraham G; Ravi R; Venkat SR; Krishnan S; Padma G; Division of Nephrology, Tamilnad Hospitals, Madras.
Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter.: J Biol Chem. 1995 Mar 3;270(9):4575-87. Unique Identifier : AIDSLINE GENBANK/L34673; Sheridan PL; Schorpp M; Voz ML; Jones KA; Salk Institute for Biological Studies, La Jolla, California; 92037.; We have isolated a human cDNA clone encoding HIP116, a protein that binds to the SPH repeats of the SV40 enhancer and to the TATA/inhibitor region of the human immunodeficiency virus (HIV)-1 promoter. The predicted HIP116 protein is related to the yeast SNF2/SWI2 transcription factor and to other members of this exten
Regulation of HIV-1 gag protein subcellular targeting by protein kinase C.: J Biol Chem. 1995 Mar 3;270(9):4792-6. Unique Identifier : AIDSLINE MED/95181479; Yu G; Shen FS; Sturch S; Aquino A; Glazer RI; Felsted RL; Laboratory of Biological Chemistry, National Cancer Institute,; NIH, Bethesda, Maryland 20892-4255.; The human immunodeficiency virus type 1 internal structural protein precursor, p55, and its corresponding matrix proteolytic fragment, p17, are phosphorylated at Ser111 by protein kinase C. COS-7 cells transfected with plasmids encoding either the wild-type or Ser111-->Ala mutated human immunodeficiency virus type 1 g
Demographic and sociocultural factors influencing contraceptive use in Uganda.: J Biosoc Sci. 1995 Jan;27(1):47-60. Unique Identifier : AIDSLINE MED/95181525; Agyei WK; Migadde M; Futures Group, Washington, DC.; Bivariate and multivariate analyses of the influence of demographic and sociocultural factors on contraceptive knowledge, attitudes and practice among currently married respondents in Uganda show that: (1) contraceptive knowledge is widespread, even among women with no education; (
EB9, a new antibody for the detection of trophozoites of Pneumocystis carinii in bronchoalveolar lavage specimens in AIDS.: J Clin Pathol. 1994 Dec;47(12):1108-11. Unique Identifier : AIDSLINE MED/95181620; Wazir JF; Brown I; Martin-Bates E; Coleman DV; Department of Cytopathology, St Mary's Hospital, London.; AIM--To prepare a monoclonal antibody (EB9) against the trophozoite form of Pneumocystis carinii and to test its efficacy for detecting infection with this organism. METHOD--The sensitivity and specificity of the EB9 antibody were assessed by comparing it with other conventional stains (Papanicolaou, Giemsa and Grocot
Hybrid and allogeneic resistance to T cell grafts mediated by murine NK and CD8+ T cells.: J Immunol. 1995 Mar 15;154(6):2568-77. Unique Identifier : AIDSLINE MED/95181772; Davenport C; Haile A; Kumar V; Bennett M; Department of Pathology, University of Texas Southwestern Medical; Center, Dallas 75235.; Lethally irradiated mice can reject H-2 allogeneic or parental strain stem cells in bone marrow cell (BMC) grafts within 48 h after transplantation. This rapid rejection of BMC grafts occurs without prior sensitization and is mediated by NK1.1+ NK cells. One hypothesis to account for the ability of host NK cells to me
Expression of TNF receptors by T cells and membrane TNF-alpha by alveolar macrophages suggests a role for TNF-alpha in the regulation of the local immune responses in the lung of HIV-1-infected patients.: J Immunol. 1995 Mar 15;154(6):2928-38. Unique Identifier : AIDSLINE MED/95181808; Agostini C; Zambello R; Trentin L; Cerutti A; Enthammer C; Facco M; Milani A; Sancetta R; Garbisa S; Semenzato G; Padua University School of Medicine, Department of Clinical; Medicine, Italy.; High amounts of TNF-alpha are released by alveolar macrophages (AMs) in the lungs of patients with HIV-1 infection. To investigate the role of this cytokine in the local immune response, we studied the expression of surface receptors for TNF-alpha (TNF-Rs) and the presence of the transmembrane form of TNF-alpha (mTNF-
HIV-1 down-regulates CD4 costimulation of TCR/CD3-directed tyrosine phosphorylation through CD4/p56lck dissociation.: J Immunol. 1995 Mar 15;154(6):2996-3005. Unique Identifier : AIDSLINE MED/95181814; Kanner SB; Haffar OK; Department of Immunodeficiency/Immunosuppression, Bristol-Myers; Squibb Pharmaceutical Research Institute, Seattle, WA 98121.; One consequence of HIV type 1 (HIV-1) infection is the gradual loss of responsiveness of T lymphocytes to Ags both in vitro and in vivo. It has been suggested that the underlying mechanism that contributes to this T cell dysfunction before CD4+ cell decline involves down-regulation of surface receptors, alterations in
Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression.: J Immunol. 1995 Mar 15;154(6):3006-14. Unique Identifier : AIDSLINE MED/95181815; Nelson DM; Butters KA; Markert ML; Reinsmoen NL; McIvor RS; Institute of Human Genetics, University of Minnesota,; Minneapolis.; Purine nucleoside phosphorylase (PNP; EC 2.4.2.1) deficiency is associated with a fatal T cell immunodeficiency in children, a candidate condition for gene therapy by introduction of functional PNP sequences into either T lymphocytes or more primitive progenitor cells in the bone marrow. To test the effectiveness of P
Reducing T cell activation as a therapy for human immunodeficiency virus infection [editorial; comment]: J Infect Dis. 1995 Mar;171(3):521-2. Unique Identifier : AIDSLINE MED/95181854; Corey L
Sustained increases in CD4 cell counts in asymptomatic human immunodeficiency virus type 1-seropositive patients treated with prednisolone for 1 year [see comments]: J Infect Dis. 1995 Mar;171(3):523-30. Unique Identifier : AIDSLINE MED/95181855; Andrieu JM; Lu W; Levy R; Laboratoire d'Immunologie des Tumeurs, Hopital Laennec,; Faculte de Medecine Necker, Universite Rene Descartes, Paris,; France.; Forty-four asymptomatic patients infected with human immunodeficiency virus type 1 (HIV-1), who had 200-799 CD4 cells/microL, received oral prednisolone (0.5 mg/kg for 6 months; 0.3 mg/kg thereafter). After 1 year of treatment, no major side effect or AIDS events had occurred. The percentage of DR+ and CD25+ phenotype
T cell function in vitro is an independent progression marker for AIDS in human immunodeficiency virus-infected asymptomatic subjects.: J Infect Dis. 1995 Mar;171(3):531-6. Unique Identifier : AIDSLINE MED/95181856; Roos MT; Miedema F; Koot M; Tersmette M; Schaasberg WP; Coutinho RA; Schellekens PT; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam.; The predictive value of low T cell reactivity to CD3 monoclonal antibodies for development of AIDS was evaluated and compared with low CD4+ cell numbers and the presence of syncytium-inducing human immunodeficiency virus (HIV) variants in 122 seropositive asymptomatic homosexual men for 4.5 years. Low T cell reactivit
Reduction of the in vitro activity of A77003, an inhibitor of human immunodeficiency virus protease, by human serum alpha 1 acid glycoprotein.: J Infect Dis. 1995 Mar;171(3):546-51. Unique Identifier : AIDSLINE MED/95181858; Bilello JA; Bilello PA; Prichard M; Robins T; Drusano GL; Department of Medicine, Albany Medical College, New York 12208.; Since plasma protein binding of antiinfectives can adversely affect drug activity, the effect of serum proteins on the in vitro antiviral activity of A77003, a human immunodeficiency virus type 1 (HIV) protease inhibitor, was investigated. In vitro, A77003 is effective in both acute and chronic infection in 10% fetal
Chronic bacterial enteropathy in patients with AIDS.: J Infect Dis. 1995 Mar;171(3):552-8. Unique Identifier : AIDSLINE MED/95181859; Kotler DP; Giang TT; Thiim M; Nataro JP; Sordillo EM; Orenstein JM; Department of Medicine, St. Luke's-Roosevelt Hospital Center, New; York, New York 10025.; Enteric infection with adherent bacteria has been seen in a person with chronic diarrhea who was infected with the human immunodeficiency virus. In this study, adherent bacteria were seen in 17% of all patients with AIDS evaluated during a 1-year period. The infection was centered in the cecum and right colon. Three d
Incidence of human T lymphotropic virus type I seroconversion after age 40 among Japanese residents in an area where the virus is endemic.: J Infect Dis. 1995 Mar;171(3):559-65. Unique Identifier : AIDSLINE MED/95181860; Takezaki T; Tajima K; Komoda H; Imai J; Division of Epidemiology, Aichi Cancer Center Research Institute,; Nagoya, Japan.; To clarify how seroconversion after age 40 years contributes to the seroprevalence of human T lymphotropic virus type I (HTLV-I), Japanese residents were studied in an area of Kyushu in which HTLV-I is endemic. Cross-sectional data showed higher seroprevalences among subjects > or = 40 than in those
Immunity to onchocerciasis: putative immune persons produce a Th1-like response to Onchocerca volvulus.: J Infect Dis. 1995 Mar;171(3):652-8. Unique Identifier : AIDSLINE MED/95181873; Elson LH; Calvopina M; Paredes W; Araujo E; Bradley JE; Guderian RH; Nutman TB; Laboratory of Parasitic Diseases, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892.; Immunity to Onchocerca volvulus (Ov) infection is suggested by the presence of putatively immune (PI) subjects in a region of Ecuador in which Ov is endemic. PI subjects were identified by traditional diagnostic methods combined wit
Elevated levels of activities of beta-hexosaminidase and alpha-mannosidase in human immunodeficiency virus-infected patients.: J Infect Dis. 1995 Mar;171(3):683-6. Unique Identifier : AIDSLINE MED/95181878; Lugering N; Stoll R; Siekmann A; Faulhaber J; Heese C; Dietrich O; Kucharzik T; Busch H; Hasilik A; Domschke W; Department of Medicine B, University of Munster, Germany.; To determine their value as markers of the clinical stage of human immunodeficiency virus (HIV) disease, plasma activities of lysosomal glycosidases were determined in the plasma of 97 HIV-infected patients: molecular forms of cathepsin D were characterized by Western blot to examine the mode of enzyme release. In pat
Rapid progression to disease in African sex workers with human immunodeficiency virus type 1 infection.: J Infect Dis. 1995 Mar;171(3):686-9. Unique Identifier : AIDSLINE MED/95181879; Anzala OA; Nagelkerke NJ; Bwayo JJ; Holton D; Moses S; Ngugi EN; Ndinya-Achola JO; Plummer FA; Department of Medical Microbiology, University of Nairobi, Kenya.; From a cohort of female sex workers in Nairobi, Kenya , 163 women were observed to seroconvert to human immunodeficiency virus type 1 (HIV-1) and followed to study progression to HIV-1-related disease. The effect of several covariables on disease progression was studied using a Weibu
Factors associated with early clinical recognition of children with perinatal human immunodeficiency virus infection. Northern California Pediatric HIV Consortium.: J Infect Dis. 1995 Mar;171(3):689-92. Unique Identifier : AIDSLINE MED/95181880; Maldonado YA; Wang NE; Caldwell B; Department of Pediatrics, Stanford University School of Medicine,; California 94305.; Surveillance of children born to women with human immunodeficiency virus (HIV) infection at five pediatric regional centers assessed times and patterns of clinical recognition in these children. Regional HIV seroprevalences among childbearing women were used to assess the proportion of identified children born to HIV-
The risk of human T cell leukemia virus and viral hepatitis infection among US Marines stationed in Okinawa, Japan.: J Infect Dis. 1995 Mar;171(3):693-6. Unique Identifier : AIDSLINE MED/95181881; Brodine SK; Hyams KC; Molgaard CA; Ito SI; Thomas RJ; Roberts CR; Golbeck AL; Oldfield EC 3rd; Blattner WA; Department of Health Sciences and Epidemiology, Naval Health; Research Center, Graduate School of Public Health, San Diego,; California 92186-5122.; The prevalence and incidence of human T cell leukemia virus type I/II (HTLV-I/II) and hepatitis A, B, and C virus infection were determined among US Marines stationed in Okinawa, Japan . Of 2875 personnel, 2 (0.07%) had antibody to HTLV-I/II. After 1-3 years, no HTLV seroconversions
Pneumonia and bacteremia by pneumococcal serotype 16 in a human immunodeficiency virus-infected child with normal serum antibody response to 23-valent pneumovax vaccine [letter]: J Infect Dis. 1995 Mar;171(3):761-2. Unique Identifier : AIDSLINE MED/95181900; Hirschfeld S; Schiffman G; Tudor-Williams G; Pizzo PA
Clinical experience with an inactivated hepatitis A vaccine.: J Infect Dis. 1995 Mar;171 Suppl 1:S44-9. Unique Identifier : AIDSLINE MED/95181910; Clemens R; Safary A; Hepburn A; Roche C; Stanbury WJ; Andre FE; SmithKline Beecham Biologicals, Rixensart, Belgium.; Clinical trials of an inactivated hepatitis A vaccine have encompassed 104 studies completed by December 1993 in 27 countries. Studies involved 50,677 subjects and administration of > 120,000 vaccine doses. Results show that the vaccine is safe, clinically well-tolerated, and highly immunogenic in all age groups. A se
The diagnosis of anal ulcers in AIDS patients.: Int J Colorectal Dis. 1994;9(4):169-73. Unique Identifier : AIDSLINE MED/95181979; Cohen SM; Schmitt SL; Lucas FV; Wexner SD; Department of Colorectal Surgery, Cleveland Clinic Florida, Ft.; Lauderdale.; Recent reports have suggested that routine microscopic evaluation of anal ulcer tissue from AIDS patients is not the most accurate way to diagnose viral infection. This study was undertaken to determine if either viral culture (VC) or immunohistochemistry (IHC) can improve the diagnostic accuracy as compared with rout
Mycobacterium marches back.: J Laryngol Otol. 1995 Jan;109(1):5-13. Unique Identifier : AIDSLINE MED/95182002; Williams RG; Douglas-Jones T; Department of Otolaryngology, University Hospital of Wales,; Cardiff, UK.; The resurgence of tuberculosis world-wide and its association with HIV infection means a greater likelihood of otolaryngologists encountering the disease in one form or another. In this review the features of primary and secondary tuberculosis in various head and neck sites are described, and recent advances in diagno
Prevalence of drug resistance in Thai human immunodeficiency virus seropositive tuberculosis patients.: J Med Assoc Thai. 1994 Jul;77(7):363-7. Unique Identifier : AIDSLINE MED/95182018; Hongthiamthong P; Chuchottaworn C; Amatayakul N; Central Chest Hospital, Department of Communicable Disease; Control, Ministry of Public Health, Nonthaburi, Thailand.; The emergence of drug resistant tuberculosis has been reported from many countries which have had epidemics of human immunodeficiency virus (HIV) infection. This study was conducted at the Central Chest Hospital, Thailand in order to determine the prevalence of drug resistance be
Clinical study of HIV disease in the lower area of northern Thailand in 1994.: J Med Assoc Thai. 1994 Aug;77(8):440-3. Unique Identifier : AIDSLINE MED/95182031; Swasdisevi A; Department of Psychiatry and Drug Abuse, Budhachinaraj Hospital,; Phitsanulok, Thailand.; Seventy-seven HIV-positive patients admitted to Budhachinaraj Hospital between February and July 1994 were studied. The sex ratio between male and female was 4.1:1 The majority of cases were sexually transmitted. There were 25 cases of symptomatic HIV and 52 cases of full-blown AIDS. The treatment in this study was bo
Evaluation of a rapid assay system, HIV 1/HIV 2 Testpack, Abbott, to detect human immunodeficiency virus antibodies in postmortem blood.: J Forensic Sci. 1995 Jan;40(1):113-5. Unique Identifier : AIDSLINE MED/95182059; Zehner R; Bratzke H; Mebs D; Department of Legal Medicine, University of Frankfurt/Main,; Germany.; For evaluating the HIV 1/HIV 2 Testpack (Abbott, Chicago, IL) to detect antibodies to human immunodeficiency virus (HIV) in whole postmortem blood 456 samples were collected prior forensic autopsies. All samples were tested using the enzyme-linked immunoassay (ELISA) and the Testpack; positively reactive samples and s
Chronic dacryosialadenitis in HTLV I associated myelopathy.: J Neurol Neurosurg Psychiatry. 1995 Feb;58(2):244-6. Unique Identifier : AIDSLINE MED/95182132; Cartier L; Castillo JL; Cea JG; Villagra R; Departamento de Ciencias Neurologicas, Universidad de Chile.; A prospective study was carried out on 48 patients with HTLV I associated myelopathy/tropical spastic paraparesis (HAM/TSP) to assess the association between this entity and Sjogren s syndrome. Fourteen patients (29.1%) had chronic dacryosialadenitis confirmed by a positive Schirmer s test and salivary gland biopsy. N
Retroviral infection (HTLV-I) induces cytokine-regulated immunomodulation and cytotoxicity of medulloblastoma cells.: J Neuropathol Exp Neurol. 1995 Mar;54(2):165-74. Unique Identifier : AIDSLINE MED/95182155; Giraudon P; Bernard A; Malcus C; Dufay N; Desgranges C; Belin MF; U433 INSERM, Laboratoire Anatomie Pathologique, Faculte de; Medicine Alexis Carrel, Lyon, France.; Primitive neuroectodermal tumors are thought to result from disturbed differentiation of neuroepithelial stem cells. These tumor cells retain the capacity to differentiate toward the neuron or glia phenotype under extrinsic stimuli. Previously, we have developed a model for the differentiation of a medulloblastoma cel
On the use of LUDI to search the Fine Chemicals Directory for ligands of proteins of known three-dimensional structure.: J Comput Aided Mol Des. 1994 Oct;8(5):623-32. Unique Identifier : AIDSLINE MED/95182175; Bohm HJ; BASF AG, Ludwigshafen, Germany.; It is shown that the computer program LUDI can be used to search large database of three-dimensional structures for putative ligands of proteins with known 3D structure. As an example, a subset of approximately 30,000 small molecules (with less than 40 atoms and 0-2 rotatable bonds) from the Fine Chemicals Directory h
Evaluation of a curriculum for adequacy of AIDS content.: J Nurs Educ. 1995 Jan;34(1):45-7. Unique Identifier : AIDSLINE MED/95182189; Nettle C; Beltz C; Benchot R; Brown K; Freund B; Gosnell D; Jones S; Shaffer J; Stopper C; Wood S; Kent State University, Ohio 44242.
Human milk glycosaminoglycans inhibit HIV glycoprotein gp120 binding to its host cell CD4 receptor.: J Nutr. 1995 Mar;125(3):419-24. Unique Identifier : AIDSLINE MED/95182193; Newburg DS; Linhardt RJ; Ampofo SA; Yolken RH; Shriver Center for Mental Retardation, Waltham, MA 02254.; The binding of the HIV envelope glycoprotein, gp120, to its host cell receptor, CD4, is inhibited in a solid phase assay by a glycosaminoglycan of human milk; this binding is the essential first step in HIV infectivity. The human milk glycosaminoglycans were identified in this study. Pooled, fractionated human milk co
The prevalence of Helicobacter pylori positivity in human immunodeficiency virus-infected children.: J Pediatr Gastroenterol Nutr. 1994 Nov;19(4):417-20. Unique Identifier : AIDSLINE MED/95182276; Blecker U; Keymolen K; Lanciers S; Bahwere P; Souayah H; Levy J; Vandenplas Y; Department of Pediatrics, Hopital Universitaire Saint Pierre,; Brussels, Belgium.; To investigate the prevalence of Helicobacter pylori infection in pediatric patients infected with the human immunodeficiency virus, we sought to detect the presence of antibodies against this organism in 23 human immunodeficiency virus-infected children of central African ethnic origin by means of a second-generation
Assessing persons with human immunodeficiency virus (HIV) infection using the Beck Depression Inventory: disease processes and other potential confounds.: J Pers Assess. 1995 Feb;64(1):86-100. Unique Identifier : AIDSLINE MED/95182379; Kalichman SC; Sikkema KJ; Somlai A; Center for AIDS Intervention Research, Medical College of; Wisconsin.; Symptoms of Human Immunodeficiency Virus (HIV) infection and somatic symptoms of depression overlap, confounding clinical assessments of persons with HIV infection. This research examined the extent of this confounding. In Study 1, 71 persons with HIV infection demonstrated high rates of depression on the Beck Depress
The integration of alternative treatment modalities in HIV infection--the patient's perspective.: J Psychosom Res. 1994 Oct;38(7):687-93. Unique Identifier : AIDSLINE MED/95182409; Langewitz W; Ruttimann S; Laifer G; Maurer P; Kiss A; Department of Internal Medicine, University Hospital,; Switzerland.; The relationship between professionals representing conventional treatment (CT) and professionals representing non-conventional therapies (alternative therapy (AT) and/or psychotherapy (PT)) is usually characterized by mutual scepticism and mistrust, the overriding fear being that either side will evoke unjustified ho
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo [4,5,1-jk][1,4]benzodiazepin-2(1H)-one (TIBO) derivatives. 3.: J Med Chem. 1995 Mar 3;38(5):771-93. Unique Identifier : AIDSLINE MED/95182429; Breslin HJ; Kukla MJ; Ludovici DW; Mohrbacher R; Ho W; Miranda M; Rodgers JD; Hitchens TK; Leo G; Gauthier DA; et al; Janssen Research Foundation, Spring House, Pennsylvania 19477.; 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2 (1H)-ones (TIBO), 1, have been shown to significantly inhibit HIV-1 replication in vitro by interfering with the virus s reverse transcriptase enzyme. They have also demonstrated potential clinical efficacy in combating HIV-1, on the basis of a prelimina
Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo-[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TlBO) derivatives. 4.: J Med Chem. 1995 Mar 3;38(5):794-802. Unique Identifier : AIDSLINE MED/95182430; Ho W; Kukla MJ; Breslin HJ; Ludovici DW; Grous PP; Diamond CJ; Miranda M; Rodgers JD; Ho CY; De Clercq E; et al; Janssen Research Foundation, Spring House, Pennsylvania 19477.; In previous papers, we have described the discovery of a new series of compounds, 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(- 1 H)- ones, TlBO (1 and 1a), with potent anti-HIV-1 activity and the synthesis of analogues to better define the structure-activity relationships (SAR) in terms of change
Strong synergistic effects of multicomponent vaccine for human immunodeficiency virus infection.: J Clin Lab Immunol. 1993;40(3):97-113. Unique Identifier : AIDSLINE MED/95182440; Okuda K; Kaneko T; Yamakawa T; Tanaka S; Hamajima K; Shigematsu T; Yamamato A; Kawamoto S; Department of Bacteriology, Yokohama City University School of; Medicine, Japan.; Several peptides were synthesized, based on sequences of the HTLV-IIIB, HTLV-IIRF, and HTLV-IIIMN strains. These corresponded to the V3 region, the killer T cell activating site, the constant region of env, gag region protein and the helper T cell activating site. Some of these peptides were coupled to keyhole limpet
[Tumor necrosis factor and AIDS]: Med Clin (Barc). 1995 Jan 14;104(1):29-36. Unique Identifier : AIDSLINE MED/95182652; Aznar Munoz R; Unidad de Enfermedades Infecciosas, Hospital General San Jorge,; Huesca.
[Thrombocytopenia associated to human immunodeficiency virus infection (letter)]: Med Clin (Barc). 1995 Jan 28;104(3):118-9. Unique Identifier : AIDSLINE MED/95182664; Dominguez-Castellano A
[Thrombocytopenia associated with human immunodeficiency virus infection (letter)]: Med Clin (Barc). 1995 Jan 28;104(3):119. Unique Identifier : AIDSLINE MED/95182666; Muniz-Diaz E; Domingo P; Madoz P
[Tuberculosis in La Rioja from 1988 to 1993. Clinical course, localization, influence of human immunodeficiency virus infection, and sensitivity of mycobacterial tests]: Med Clin (Barc). 1995 Jan 28;104(3):81-4. Unique Identifier : AIDSLINE MED/95182667; Labarga Echeverria P; Perucha Gonzalez M; Jimenez Gomez E; Anton Botella F; Calavia Rueda N; Pinilla Moraza J; Gomez Martinez MI; Milazzo Estefania A; Servicio de Medicina Interna, Hospital San Millan, INSALUD,; Logrono.; BACKGROUND: The present study was performed to analyze the evolution of the incidence of tuberculosis in La Rioja ( Spain ) from January 1988 to March 1993. The influence of factors such as HIV infection and alcoholism was analyzed. The sensitivity of the bacilloscopy in the diagnosis
[Resistant tuberculosis in a prison population during 1991-1993]: Med Clin (Barc). 1995 Jan 28;104(3):85-8. Unique Identifier : AIDSLINE MED/95182668; Chaves F; Dronda F; Ortega A; Alonso-Sanz M; Lopez-Cubero L; Gonzalez-Lopez A; Catalan S; Enfermedades Infecciosas-Microbiologia, Servicio de Medicina,; Hospital General Penitenciario, Madrid.; BACKGROUND: To know the prevalence of resistant tuberculosis and the characteristics of the same in the penitentiary medium in the Madrid area ( Spain ). METHODS: From March 1, 1991 to August 31, 1993 a prospective study was carried out in patients with isolations of Mycobacterium tub
[Changes in bone marrow among HIV-positive and HIV-negative parenteral drug addicts]: Med Clin (Barc). 1995 Jan 28;104(3):89-91. Unique Identifier : AIDSLINE MED/95182669; Gonzalez Aza C; Grilo Reina A; Lopez Martin JC; Torre Sabariego A; Martinez Estefano E; Lopez Lacomba D; Herrera Diaz A; Moreno Garrido D; Servicio de Hematologia, Hospital Universitario de Valme.; Sevilla.; BACKGROUND: The aim of the present was to study the cytohistology of the bone marrow in intravenous drug addicts (IVDA) and to analyze the possible differences according to the period of drug addiction. METHODS: A prospective study was performed in 60 IVDA patients previously untreated and distributed into three group
[Intestinal microsporidiosis in patients with AIDS: study of 3 cases]: Med Clin (Barc). 1995 Jan 28;104(3):96-9. Unique Identifier : AIDSLINE MED/95182672; Miro O; Moreno A; Valls ME; Miro JM; Pique JM; Bordas JM; Moreno-Martinez A; Bombi JA; Gatell JM; Servicio de Enfermedades Infecciosas, Hospital Clinic i; Provincial, Facultad de Medicina, Universidad de Barcelona.; Enterocytozoon bieneusi is a protozoa belonging to the Microsporidia family which prevalence has increased in AIDS patients. Although diagnosis is performed by the demonstration of the parasite in the epithelium of the small intestine by light and electron microscopy, techniques allowing diagnosis from stools or duode
[Immunologic dysfunction and HIV (editorial)]: Med Clin (Barc). 1995 Feb 11;104(5):178-9. Unique Identifier : AIDSLINE MED/95182677; Quiros E; Gonzalez I
[The role of zidovudine and cesarean section in the prevention of vertical transmission of HIV (see comments)]: Med Clin (Barc). 1995 Feb 11;104(5):183-4. Unique Identifier : AIDSLINE MED/95182679; Coll O; Martinez de Tejada B; Sanchez E; Subdivision de Obstetricia y Ginecologia, Hospital Clinic i; Provincial, Universitat de Barcelona.
[Fever, adenopathies, hepatosplenomegaly and cutaneous lesions in a 31-year-old woman with human immunodeficiency virus infection (clinical conference)]: Med Clin (Barc). 1995 Feb 11;104(5):188-95. Unique Identifier : AIDSLINE MED/95182681; Sahuquillo JC; Moysset I; Servicio de Medicina Interna, Hospital Universitari Germans Trias; i Pujol, Badalona, Barcelona.
[Primary lateral sclerosis in an AIDS patient. Magnetic resonance imaging (letter)]: Med Clin (Barc). 1995 Feb 11;104(5):196. Unique Identifier : AIDSLINE MED/95182682; Dias Silva JJ; Rey del Corral P; Martinez Muniz A; Pedreira Andrade JD
[A new case of idiopathic T CD4+ lymphocytopenia and opportunistic infection without HIV infection (letter)]: Med Clin (Barc). 1995 Feb 11;104(5):198-9. Unique Identifier : AIDSLINE MED/95182685; Sanchez Roman J; Castillo Palma MJ; Torronteras Santiago R; Pastor Ramos MT
Human immunodeficiency virus infection and hepatitis C pathology.: Liver. 1994 Dec;14(6):314-9. Unique Identifier : AIDSLINE MED/95182797; Guido M; Rugge M; Fattovich G; Rocchetto P; Cassaro M; Chemello L; Noventa F; Giustina G; Alberti A; Cattedra di Istochimica ed Immunoistochimica Patologica,; Universita di Padova, Italy.; To investigate the possible influence of human immunodeficiency virus (HIV) infection on hepatitis C virus-related liver disease, liver morphology was evaluated in 160 HBsAg-negative patients with chronic hepatitis C, including 68 HIV-positive and 92 HIV-negative cases. No differences were detected in the severity of
Attitudes toward HIV testing among impoverished inner-city African-American women.: Med Anthropol. 1994 Nov;16(1):17-38. Unique Identifier : AIDSLINE MED/95182827; Sobo EJ; Department of Sociology and Anthropology, New Mexico State; University, Las Cruces 88003-0001.; During a study of the perceived benefits of unsafe (condomless) sex, some women s erroneous convictions that they have been tested for HIV seropositivity and most women s reluctance to identify their own sexual behaviors at high-risk when explaining why they had been tested were noted. Many participants assumed that c
Loss and regeneration: influences on the reproductive decisions of HIV positive, drug-using women.: Med Anthropol. 1994 Nov;16(1):39-62. Unique Identifier : AIDSLINE MED/95182828; Pivnick A; Department of Epidemiology and Social Medicine, Montefiore; Medical Center, Bronx, New York 10467.; Current approaches to the reduction of perinatal transmission of HIV infection among drug-using women focus on the content of counseling sessions which may include suggestions to abstain from sexual intercourse, to use barrier contraceptives, or to terminate pregnancy. The broader social and cultural issues which may
Negotiating sexual relationships after testing HIV-positive.: Med Anthropol. 1994 Nov;16(1):63-77. Unique Identifier : AIDSLINE MED/95182829; Adam BD; Sears A; University of Windsor, Ontario, Canada.; Drawing on in-depth interviews with 60 people with HIV disease and 40 of their caregivers, this article reports on the effects of HIV seropositivity on sexual interaction and relationship formation. Using a sample representing gay and heterosexual, black and white, and male and female respondents, we focus on how peop
Medical confidentiality in sport and the public interest.: Med Sci Law. 1995 Jan;35(1):45-7. Unique Identifier : AIDSLINE MED/95182838; McConnell AA; MacKay MG; Inverclyde Royal NHS Trust Hospital, Greenock.
Standardization for flow cytometry.: Methods Cell Biol. 1994;42 Pt B:605-26. Unique Identifier : AIDSLINE MED/95182898; Schwartz A; Fernandez-Repollet E; Flow Cytometry Standards Corporation San Juan, Puerto Rico.
False-negative results for HIV-1 [letter]: Med J Aust. 1995 Feb 20;162(4):220. Unique Identifier : AIDSLINE MED/95182937; Anderson JS; Locarnini SA; Doherty RR; Breschkin AM; Dax EM; Mijch AM
Seminars in medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome [see comments]: N Engl J Med. 1995 Apr 6;332(14):934-40. Unique Identifier : AIDSLINE MED/95183096; Lipton SA; Gendelman HE; Department of Neurology, Children's Hospital, Boston, MA 02115.
Cost of HIV testing in the U.S. Army [letter]: N Engl J Med. 1995 Apr 6;332(14):963. Unique Identifier : AIDSLINE MED/95183113; Brown AE; Burke DS
Blood warning 'urgent' says Canadian judge [news]: Nature. 1995 Mar 9;374(6518):106. Unique Identifier : AIDSLINE MED/95183120; Spurgeon D
Recombination in HIV-1 [letter]: Nature. 1995 Mar 9;374(6518):124-6. Unique Identifier : AIDSLINE MED/95183131; Robertson DL; Sharp PM; McCutchan FE; Hahn BH
[One antibody preparation is not another: the role of passive immunotherapy in the treatment of HIV infection]: Ned Tijdschr Geneeskd. 1995 Feb 18;139(7):316-20. Unique Identifier : AIDSLINE MED/95183151; Leverstein-van Hall MA; Goudsmit J; Academisch Medisch Centrum, vakgroep Medische Microbiologie,; Universiteit van Amsterdam.
Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred strain of mouse infected with Trichuris muris.: Parasite Immunol. 1993 Oct;15(10):595-600. Unique Identifier : AIDSLINE MED/95183305; Else KJ; Entwistle GM; Grencis RK; Department of Cell & Structural Biology, University of; Manchester, UK.; Helper T cell subset induction was examined within a single inbred strain of mouse (B10.D2/n) where individuals varied in their ability to expel the nematode parasite Trichuris muris. In this mouse strain approximately half of infected individuals resist infection whilst half are unable to expel the parasite and harbo
[Aspergillosis in acquired immunodeficiency syndrome]: Pathol Biol (Paris). 1994 Sep;42(7):647-51. Unique Identifier : AIDSLINE MED/95183329; Meyohas MC; Roux P; Poirot JL; Meynard JL; Frottier J; Service de Parasitologie, Hopital Tenon, Paris, France.; From 1983 to 1991 only isolated cases of aspergillosis in AIDS patients were reported; since 1991, an increasing number of cases have been reported suggesting a recent emergence of this fungal infection. Aspergillosis occurs about 10 to 25 months after AIDS diagnosis in patients with CD4 below 50/mm3. Neutropenia and/
Methadone maintenance treatment. When and how to refer patients [see comments]: Postgrad Med. 1995 Mar;97(3):83-6, 91-2. Unique Identifier : AIDSLINE MED/95183407; DeMaria PA Jr; Weinstein SP; Department of Psychiatry and Human Behavior, Jefferson Medical; College, Philadelphia, PA 19107.; Methadone, a long-acting oral narcotic analgesic, prevents withdrawal symptoms and craving over a 24-hour period in patients addicted to narcotics. Methadone maintenance treatment programs have been shown to decrease criminal behavior, improve psychosocial functioning, and decrease injecting narcotic use, thus reducin
The U3 promoter region of the acutely lethal simian immunodeficiency virus clone smmPBj1.9 confers related biological activity on the apathogenic clone agm3mc.: Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1362-6. Unique Identifier : AIDSLINE MED/95183466; Dittmar MT; Cichutek K; Fultz PN; Kurth R; Department of Medical Biotechnology, Paul-Ehrlich-Institut,; Langen, Germany.; Infection with the acutely pathogenic molecular virus clone SIVsmmPBj1.9, cloned from isolate PBj14 of simian immunodeficiency virus (SIV) from sooty mangabey monkeys (Cercocebus atys), leads to acute viral and often lethal disease within days or weeks. SIVsmmPBj1.9 has the unique property of replicating in nonstimula
An early increase in somatostatin mRNA expression in the frontal cortex of rhesus monkeys infected with simian immunodeficiency virus.: Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1371-5. Unique Identifier : AIDSLINE MED/95183468; Da Cunha A; Rausch DM; Eiden LE; Section on Molecular Neuroscience, National Institute of Mental; Health, National Institutes of Health, Bethesda, MD 20892.; Motor and cognitive impairment is common in human immunodeficiency virus disease in humans and simian immunodeficiency virus (SIV) disease in rhesus monkeys. We have examined peptide neurotransmitter expression in the frontal cortex of SIV-infected rhesus monkeys to identify alterations in cortical neurons that might
Regulation of human retroviral latency by the NF-kappa B/I kappa B family: inhibition of human immunodeficiency virus replication by I kappa B through a Rev-dependent mechanism.: Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1480-4. Unique Identifier : AIDSLINE MED/95183489; Wu BY; Woffendin C; Duckett CS; Ohno T; Nabel GJ; Howard Hughes Medical Institute, University of Michigan Medical; Center, Ann Arbor 48109-0650.; The cellular transcription factor NF-kappa B stimulates human immunodeficiency virus type 1 (HIV-1) transcriptional initiation, but its role in the retroviral life cycle has not been fully defined. In this report, we show that I kappa B alpha acts as a cellular inhibitor of human retroviral replication through a discr
Monocytes are required to prime peripheral blood T cells to undergo apoptosis.: Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1525-9. Unique Identifier : AIDSLINE MED/95183498; Wu MX; Daley JF; Rasmussen RA; Schlossman SF; Division of Tumor Immunology, Dana-Farber Cancer Institute,; Boston, MA.; Freshly isolated, human peripheral blood T (PBT) cells are largely resistant to the apoptotic effects of anti-CD3 monoclonal antibody, ionomycin, or phorbol 12-myristate 13-acetate (PMA). We demonstrate here, however, that PBT cells, including both CD4+ and CD8+ cell populations, can be readily induced to undergo apop
[New drug policies: the Geneva example]: Psychiatr Enfant. 1994;37(2):577-99. Unique Identifier : AIDSLINE MED/95183637; Mino A; Division pour toxicodependants, IUPG, Geneve.; As a consequence of the negative medical social effects of illicit drug use a certain number of countries, during the eighties, have chosen to rethink their therapeutical strategies which were mainly aimed at instoring rapid abstinence. Risk-reduction strategies are varied, including distribution of syringes, substitu
[Anticardiolipin antibodies in parenteral drug addicts: relationship with HIV]: Rev Clin Esp. 1995 Jan;195(1):8-11. Unique Identifier : AIDSLINE MED/95183794; Gonzalez Dominguez J; Ortega C; Jurado R; Munoz ML; Torre-Cisneros J; Kindelan JM; Santamaria M; Seccion de Reumatologia, Hospital Universitario Reina Sofia,; Cordoba.; The IgG isotype of anticardiolipin antibodies (aCL) and its possible relationship with the immunodeficiency virus (HIV) were studied in 65 parenteral drug addicts (PDA). Thirty-seven patients were infected in the present study. Nineteen (51%) fulfilled diagnostic criteria of AIDS. Thirty-two of these 37 HIV-positive p
AIDS research policy [letter; comment]: Science. 1995 Mar 10;267(5203):1405-7. Unique Identifier : AIDSLINE MED/95183990; Paul WE
AIDS research policy [letter]: Science. 1995 Mar 10;267(5203):1406. Unique Identifier : AIDSLINE MED/95183991; Cox S
AIDS research policy [letter]: Science. 1995 Mar 10;267(5203):1406-7. Unique Identifier : AIDSLINE MED/95183992; Goldberg B; Stricker RB
Targeting retroviral integration [comment]: Science. 1995 Mar 10;267(5203):1443-4. Unique Identifier : AIDSLINE MED/95184002; Bushman F; Infectious Disease Laboratory, Salk Institute, La Jolla, CA; 92037.
Apoptosis in the pathogenesis and treatment of disease.: Science. 1995 Mar 10;267(5203):1456-62. Unique Identifier : AIDSLINE MED/95184005; Thompson CB; Howard Hughes Medical Institute, Department of Medicine, Chicago,; IL 60637.; In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death. Although much is known about the control of cell proliferation, less is known about the control of cell death. Physiologic cell death occurs primarily through an evolutionarily conserved form of cell suic
Tuberculosis: pathogenesis and laboratory diagnosis.: Occup Med. 1994 Oct-Dec;9(4):561-74. Unique Identifier : AIDSLINE MED/95184034; Ford JG; Felton CP; Department of Medicine, Columbia College of Physicians and; Surgeons, New York, NY.; Emerging molecular biologic technologies hold the promise of more rapid diagnosis of tuberculosis and more definitive epidemiologic linkages of cases of TB. In addition to reviewing the pathogenesis of tuberculosis, this chapter covers a variety of methods for the rapid detection of the disease, including the acid-fas
The relationship between TB and HIV infections.: Occup Med. 1994 Oct-Dec;9(4):575-87. Unique Identifier : AIDSLINE MED/95184035; Rose DN; AIDS Center, Mount Sinai Hospital, New York, New York.; AIDS is widely believed to be the strongest influence on the spread of tuberculosis, one of the most common opportunistic infections in people infected with the human immunodeficiency virus. In this chapter, the author details the unique interrelationship between these two widespread infections as well as their epidem
Educating workers about tuberculosis.: Occup Med. 1994 Oct-Dec;9(4):681-94. Unique Identifier : AIDSLINE MED/95184041; Watson LH; Rosen JD; New York Committee for Occupational Safety and Health, New York; 10001.; At a state penitentiary, workers are told that the communicable disease unit is a safe environment in which to work due to the negative air pressure in the isolation rooms and the improved ventilation system. However, nobody is trained to monitor the system or understands the role of negative air pressure, and isolati
Recruitment of host CD8+ T cells by tumor-infiltrating lymphocytes and recombinant interleukin-2 during adoptive immunotherapy of cancer.: Surgery. 1995 Mar;117(3):325-33. Unique Identifier : AIDSLINE MED/95184087; Burger UL; Chang MP; Goedegebuure PS; Eberlein TJ; Department of Surgery, Brigham & Women's Hospital, Harvard; Medical School, Boston, MA 02115.; BACKGROUND. Previously we demonstrated that optimal doses of tumor-infiltrating lymphocytes (TIL) concomitant with recombinant interleukin-2 (rIL-2) effectively mediated complete tumor regression of murine 3-day pulmonary metastases. METHODS. In the present study we have investigated the contribution of the host immun
Control and prevention of tuberculosis in the United Kingdom: Code of Practice 1994. Joint Tuberculosis Committee of the British Thoracic Society [see comments]: Thorax. 1994 Dec;49(12):1193-200. Unique Identifier : AIDSLINE MED/95184099; BACKGROUND--The guidelines on control and prevention of tuberculosis in the United Kingdom have been reviewed and updated. METHODS--A subcommittee was appointed by the Joint Tuberculosis Committee (JTC). Each member of this group drafted one or more sections of the guidelines, and draf
Bordetella bronchiseptica pneumonia [letter]: Thorax. 1994 Dec;49(12):1278. Unique Identifier : AIDSLINE MED/95184122; Lawson RA
Impact of HIV on tuberculosis in developing countries [letter]: Thorax. 1994 Dec;49(12):1278. Unique Identifier : AIDSLINE MED/95184123; Parry CM; Kamoto O; Harries AD; Nyong'onya Mbewe L; Nyangulu DS
Serological and virological markers of human parvovirus B19 infection in sera of hemophiliacs [see comments]: Thromb Haemost. 1994 Oct;72(4):503-7. Unique Identifier : AIDSLINE MED/95184172; Grosse-Bley A; Eis-Hubinger AM; Kaiser R; Oldenburg J; Brackmann HH; Schwarz TF; Schneweis KE; Institute of Medical Microbiology and Immunology, University of; Bonn, Germany.; It is known that parvovirus B19 (B19) is transmitted to hemophiliacs by clotting factors prepared from human plasma. However, it is not clear whether B19 is also transmitted by the more recently used inactivated clotting factor preparations. Therefore, we investigated 69 hemophiliacs, mostly children, receiving only v
Patterns of immunogenicity of an inactivated hepatitis A vaccine in anti-HIV positive and negative hemophilic patients.: Thromb Haemost. 1994 Oct;72(4):508-10. Unique Identifier : AIDSLINE MED/95184173; Santagostino E; Gringeri A; Rocino A; Zanetti A; de Biasi R; Mannucci PM; Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Maggiore; Hospital, Napoli, Italy.; Hepatitis A vaccination has been recommended to patients with hemophilia since they are exposed to potentially infectious clotting factor concentrates. Aim of this study was to assess the immunogenicity of vaccination in hemophiliacs, infected or not with the human immunodeficiency virus (HIV). A formalin-inactivated
Immunotoxicity of AZT: inhibitory effect on thymocyte differentiation and peripheral T cell responsiveness to gp120 of human immunodeficiency virus.: Toxicol Appl Pharmacol. 1995 Mar;131(1):53-62. Unique Identifier : AIDSLINE MED/95184239; McKallip RJ; Nagarkatti M; Nagarkatti PS; Department of Biology, College of Arts and Sciences,; Virginia-Maryland Regional College of Veterinary Medicine,; Virginia Polytechnic Institute and State University, Blacksburg; 24061.; 3 -Azido-2 ,3 -dideoxythymidine ( AZT ) is extensively used in the treatment of human immunodeficiency virus (HIV) infection. Currently, it is debated whether AZT should be offered to symptomless HIV-infected individuals in the hope of delaying or even
Determination of itraconazole and its active metabolite in plasma by column liquid chromatography.: Ther Drug Monit. 1994 Dec;16(6):596-601. Unique Identifier : AIDSLINE MED/95184263; Poirier JM; Lebot M; Descamps P; Levy M; Cheymol G; Service of Pharmacology, Saint-Antoine Hospital, Paris, France.; Itraconazole is a new triazole antifungal agent. Active orally, this drug is effective against a wide range of fungal pathogens that includes Aspergillus species, and its use in leukemic and AIDS patients is currently on the increase. Oral itraconazole absorption presents up to threefold interindividual variation in m
Effect of heating sera under conditions necessary for deactivation of human immunodeficiency virus on commonly monitored therapeutic drugs.: Ther Drug Monit. 1994 Dec;16(6):612-5. Unique Identifier : AIDSLINE MED/95184266; Dasgupta A; Bard D; Department of Pathology, University of New Mexico School of; Medicine, Albuquerque 87106.; Minimizing the risk of infection of laboratory staff from contaminated blood samples is a major safety goal in a clinical laboratory. One dangerous pathogen, the human immunodeficiency virus (HIV) can be deactivated by heating sera at 56 degrees C for 30 min. We studied the effect of such heat treatment on serum conce
Therapeutic drug monitoring of phenytoin in patients with the acquired immunodeficiency syndrome.: Ther Drug Monit. 1994 Dec;16(6):616-20. Unique Identifier : AIDSLINE MED/95184267; Burger DM; Meenhorst PL; Mulder JW; Kraaijeveld CL; Koks CH; Bult A; Beijnen JH; Department of Pharmacy, Slotervaart Hospital, Amsterdam, The; Netherlands.; Serum phenytoin concentrations were investigated in 109 serum samples from 21 patients with the acquired immunodeficiency syndrome (AIDS) and in 1,231 serum samples from 557 control subjects during phenytoin therapy. Total phenytoin concentrations were significantly lower in patients with AIDS than in the reference po
Low risk of viral infection after administration of vapor-heated factor VII concentrate or factor IX complex in first-time recipients of blood components. International Factor Safety Study Group.: Transfusion. 1995 Mar;35(3):204-8. Unique Identifier : AIDSLINE MED/95184275; Shapiro A; Abe T; Aledort LM; Anderle K; Hilgartner MW; Kunschak M; Preston FE; Rivard GE; Schimpf K; James Whitcomb Riley Hospital for Children, Indiana University; School of Medicine, Indianapolis.; BACKGROUND: Vapor-heated human factor VII concentrate and human factor IX complex are both obtained from prothrombin complex, undergo similar methods of manufacture, and are subjected to an identical two-step vapor-heating process for virus inactivation. STUDY DESIGN AND METHODS: Intermediate-purity vapor-heated human
Reduction in transmission of hepatitis C after the introduction of a heat-treatment step in the production of C1-inhibitor concentrate [see comments]: Transfusion. 1995 Mar;35(3):209-12. Unique Identifier : AIDSLINE MED/95184276; Cicardi M; Mannucci PM; Castelli R; Rumi MG; Agostoni A; Institute of Internal Medicine, Maggiore Hospital, Milan, Italy.; BACKGROUND: The transmission of viral infections via protein concentrates made from a large pool of plasma depends on the selection of donors, fractionation process, and virucidal methods. To date, no data are available on the infectivity risk of plasma concentrates of the inhibitor of the first component of complemen
Human T-lymphotropic virus type I and type II infections and correlation with risk factors in blood donors from Sao Paulo, Brazil.: Transfusion. 1995 Mar;35(3):258-63. Unique Identifier : AIDSLINE MED/95184284; Ferreira Junior OC; Vaz RS; Carvalho MB; Guerra C; Fabron AL; Rosemblit J; Hamerschlak N; Hemotherapy Service, Albert Einstein Hospital, Sao Paulo,; Brazil.; BACKGROUND: Little is known about the prevalence of and risk factors for human T-lymphotropic virus type I and type II (HTLV-I, HTLV-II) infections in Brazil . STUDY DESIGN AND METHODS: Sera from 17,063 healthy Brazilian donors were screened by enzyme-linked immunosorbent assay for
Infectious disease markers in blood donors in northern Thailand.: Transfusion. 1995 Mar;35(3):264-7. Unique Identifier : AIDSLINE MED/95184285; Mundee Y; Kamtorn N; Chaiyaphruk S; Nantachit N; Ness PM; Nelson KE; Blood Bank, Faculty of Medicine, Maharaj Nakorn Chiang Mai; Hospital, Thailand.; BACKGROUND: A major epidemic of human immunodeficiency virus type 1 (HIV-1) infections that are primarily due to heterosexual transmission has developed in Thailand since 1988. The epidemic has been most severe in northern Thailand. The blood banks in Chiang Mai began screening d
Evidence for a possible Th2 bias in human renal transplant tolerance.: Transplant Proc. 1995 Feb;27(1):225-6. Unique Identifier : AIDSLINE MED/95184592; Kusaka S; Grailer AP; Fechner JH Jr; Burlingham WJ; Department of Surgery, University of Wisconsin-Madison, 53792.
Rejection of rat cardiac xenografts by mouse CD4 or CD8 T cells.: Transplant Proc. 1995 Feb;27(1):264-5. Unique Identifier : AIDSLINE MED/95184611; Sakakibara N; Jamieson SW; Wolf P; Weisberg D; Click RE; Department of Cardiothoracic Surgery and Pathology, University of; California, San Diego 92103-8892.
Anti-CD4 IgG2a monoclonal antibody treatment prevents the expansion of T cells in the spleen during murine graft-vs-host disease.: Transplant Proc. 1995 Feb;27(1):384-6. Unique Identifier : AIDSLINE MED/95184668; Noort WA; Benner R; Savelkoul HF; Department of Immunology, Erasmus University, Rotterdam, The; Netherlands.
Immunological analysis of kidney allograft infiltrates during rejection: presence of cells coexpressing CD4 and CD8 antigens.: Transplant Proc. 1995 Feb;27(1):930-1. Unique Identifier : AIDSLINE MED/95184899; Trovati A; Cinti P; Tamburro ML; Lattanzi R; Baiano V; Orlandini AM; Renna Molajoni E; Cortesini R; Divisione Trapianti d'Organo, Universita di Roma La Sapienza,; Italy.
Selective inactivation of cytotoxic T lymphocytes in long-term renal transplant recipients: clonal anergy as a possible mechanism underlying allograft acceptance.: Transplant Proc. 1995 Feb;27(1):995-8. Unique Identifier : AIDSLINE MED/95184925; Fujiwara T; Sakagami K; Saitoh S; Uda M; Kusaka S; Nakagawa K; Matsuno T; Orita K; Department of Transplantation surgery, Center for Adult Diseases,; Kurashiki, Japan.
Testicular pseudotumor in the acquired immunodeficiency syndrome.: Urology. 1995 Mar;45(3):535-7. Unique Identifier : AIDSLINE MED/95185035; Smith FJ; Bilbey JH; Filipenko JD; Goldenberg SL; Department of Radiology, St. Paul's Hospital, Vancouver, British; Columbia, Canada.; We describe a case of testicular pseudotumor evaluated with both diagnostic ultrasound (US) and magnetic resonance (MR) imaging. The findings were inconclusive and eventually radical orchiectomy and pathologic analysis were required to make the diagnosis. The typical US and MR findings of both inflammatory and neoplas
Nucleic acid immunization: a prophylactic gene therapy?: Vaccine. 1994 Dec;12(16):1520-5. Unique Identifier : AIDSLINE MED/95185108; Cichutek K; Department of Biotechnology, Paul-Ehrlich-Institute, Langen,; Germany.; Nucleic acid (NA) vaccines may offer the safety of subunit or inactivated vaccines and, at the same time, provide the advantages of live recombinant vaccines, such as induction of a protective cellular immune response. In Germany , the so-called Gene Law regulates the genetic mod
Facilitated DNA inoculation induces anti-HIV-1 immunity in vivo.: Vaccine. 1994 Dec;12(16):1545-50. Unique Identifier : AIDSLINE MED/95185114; Coney L; Wang B; Ugen KE; Boyer J; McCallus D; Srikantan V; Agadjanyan M; Pachuk CJ; Herold K; Merva M; et al; Apollon Inc., Malvern, PA 19355.; Vaccine design against HIV-1 is complicated both by the latent aspects of lentiviral infection and the diversity of the virus. The type of vaccine approach used is therefore likely to be critically important. In general, vaccination strategies have relied on the use of live attenuated material or inactivated/subunit p
Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia.: Acta Neuropathol (Berl). 1994;88(6):538-44. Unique Identifier : AIDSLINE MED/95185298; Everall IP; Glass JD; McArthur J; Spargo E; Lantos P; Department of Neuropathology, Institute of Psychiatry, London,; UK.; Human immune deficiency virus (HIV) disease may be associated, neuropathologically, with significant neuronal loss and clinically with a severe dementia . However, the significance of neuronal loss in the development of dementia has not been established. In this study we have undert
The multidimensional nature of received social support in gay men at risk of HIV infection and AIDS.: Am J Community Psychol. 1994 Jun;22(3):319-39. Unique Identifier : AIDSLINE MED/95185452; Schwarzer R; Dunkel-Schetter C; Kemeny M; Freie Universitt Berlin.; This article concerns received social support in gay men at risk of HIV and AIDS. Distinctions are made between three types of support (informational, tangible, emotional), four sources of support (friends, relatives, partner, organizations), and three dimensions of support (amount, satisfaction, reciprocity). A 24-it
My place, your place, and no place: behavior settings as a risk factor for HIV-related injection practices of drug users in Baltimore, Maryland.: Am J Community Psychol. 1994 Jun;22(3):415-30. Unique Identifier : AIDSLINE MED/95185456; Latkin C; Mandell W; Vlahov D; Oziemkowska M; Knowlton A; Celentano D; Johns Hopkins University, School of Hygiene and Public Health,; Baltimore, Maryland 21205.; Information is sparse on the social context of illicit drug injection behaviors and their relationship to HIV infection. This study examined relationships between injection settings, injecting with others, and HIV risk behaviors of sharing needles and not cleaning contaminated needles in a sample of 630 inner-city inj
The spectrum of medical conditions and symptoms before acquired immunodeficiency syndrome in homosexual and bisexual men infected with the human immunodeficiency virus [see comments]: Am J Epidemiol. 1995 Mar 1;141(5):395-404; discussion 405-6. Unique Identifier : AIDSLINE MED/95185492; Holmberg SD; Buchbinder SP; Conley LJ; Wong LC; Katz MH; Penley KA; Hershow RC; Judson FN; Division of HIV/AIDS, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, GA; 30329-4018.; The full range and occurrence of medical conditions in persons infected with human immunodeficiency virus (HIV) before they develop illnesses that define acquired immunodeficiency syndrome (AIDS) have not been systematically or completely described. In a retrospective and prospective cohort study, 1,073 homosexual and
[Substitution treatments in Geneva]: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:31-3. Unique Identifier : AIDSLINE MED/95185730; Feldman N; Mino A; Division pour Toxicodependants, Institutions Universitaires de; Psychiatrie de Geneve, IUPG, Suisse.
Methadone treatment programmes in the United Kingdom.: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:34-5. Unique Identifier : AIDSLINE MED/95185731; Farrell M; Institute of Psychiatry, National Addiction Center, England, U.K.
[Report on the methadone program at the Centre Pierre-Nicole]: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:36-8. Unique Identifier : AIDSLINE MED/95185732; Wieviorka S; Centre Saint-Germain Pierre-Nicole, Paris.
[Administrative, social and clinical facilities of the implementation of the methadone program in Bordeaux]: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:43-5. Unique Identifier : AIDSLINE MED/95185735; Tignol J; Service Universitaire de Psychiatrie, Centre Carreire, Bordeaux.
[Value and limitations of substitution treatments in the care of drug addicts]: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:50-1. Unique Identifier : AIDSLINE MED/95185738; Carpentier J; Bloch-Laine JF; Hefez S
[How to treat a patient with AIDS and drug dependence unwilling and/or unable to withdraw? Give substitution drugs at the hospital? Should substitution be continued after discharge? Is substitution a useful adjuvant to programs designed to prevent opportunistic diseases?] opportunisticinfections?]: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:54-5. Unique Identifier : AIDSLINE MED/95185740; Boissonnas A; Unite pour le Sevrage des Toxicomanes, Hopital Cochin, Paris.
[Epidemiology of drug dependence and real-life experiences]: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:7-8. Unique Identifier : AIDSLINE MED/95185748; Facy F; INSERM U.302, Le Vesinet.
[Complementary prevention actions as a means of reducing risks]: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:71-2. Unique Identifier : AIDSLINE MED/95185749; Ingold FR; IREP, Paris.
[Substitution practices in Europe and reduction of risks]: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:73-4. Unique Identifier : AIDSLINE MED/95185750; Coppel A; Clinique Liberte, Bagneux.
[Do substitution treatments reduce the incidence of human immunodeficiency virus infections in intravenous heroin addicts? Review of pertinent literature]: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:75-8. Unique Identifier : AIDSLINE MED/95185751; Lowenstein W; Haas C; Durand H; Service de Medecine Interne, Hopital Laennec, Paris.
[How would the development of substitution treatments modify the care of drug addicts?]: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:79-81. Unique Identifier : AIDSLINE MED/95185752; Charles-Nicolas A; CHU de Fort-de-France.
Biological correlates of methadone maintenance pharmacotherapy.: Ann Med Interne (Paris). 1994 Nov;145 Suppl 3:9-14. Unique Identifier : AIDSLINE MED/95185757; Kreek MJ; Laboratory of the Biology of Addictive Diseases, Rockefeller; University, New York 10021.
Tonic seizures in a patient with brainstem demyelination: MRI study of brain and spinal cord.: Pediatr Neurol. 1994 Oct;11(3):258-62. Unique Identifier : AIDSLINE MED/95185955; Libenson MH; Stafstrom CE; Rosman NP; Department of Pediatrics, Floating Hospital for Children, Boston,; Massachusetts 02111.; Tonic seizures are a poorly understood manifestation of demyelinating disease, first reported in 4 patients with multiple sclerosis. We describe a patient with tonic extension of the left limbs caused by a right-sided brainstem lesion as the first manifestation of demyelinating disease. A 19-year-old man was referred
Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases [see comments]: Immunol Today. 1995 Jan;16(1):34-8. Unique Identifier : AIDSLINE MED/95186000; Liblau RS; Singer SM; McDevitt HO; Dept of Microbiology and Immunology, Stanford University School; of Medicine, CA 94305-5402.; CD4+ T cells play a key role in regulating immune system function. When these regulatory processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau, Steven Singer and Hugh McDevitt explore the thesis that a particular subset of CD4+ T cells, namely T helper 1 (Th1) cells, contributes to the
Viro-immunopathogenesis of HIV disease: implications for therapy.: Immunol Today. 1995 Jan;16(1):5-7. Unique Identifier : AIDSLINE MED/95186003; Andrieu JM; Lu W; Laboratoire d'Immunologie des Tumeurs, Hopital Laennec,; Faculte de Medecine Necker, Universite Rene Descartes, Paris; V, France.
Comment on Mosier and Sieburg [letter; comment]: Immunol Today. 1995 Jan;16(1):50-2. Unique Identifier : AIDSLINE MED/95186004; Schuitemaker H; Miedema F
Characterization of lymphocyte subpopulations and T cell activation in endometriosis.: Am J Reprod Immunol. 1994 Oct;32(3):173-9. Unique Identifier : AIDSLINE MED/95186015; Witz CA; Montoya IA; Dey TD; Schenken RS; Department of Obstetrics and Gynecology, University of Texas; Health Science Center at San Antonio 78284-7836.; PROBLEM: Numerous studies have characterized the lymphocyte subpopulations in normal eutopic endometrium and suggested a role for the cytokine secretory products of these lymphocytes in regulating endometrial cell proliferation and differentiation. Recent studies have shown that ectopic endometrium contains a greater
Maternal peripheral blood lymphocyte subpopulations in normal and pathological pregnancies.: Fetal Diagn Ther. 1994 Nov-Dec;9(6):371-8. Unique Identifier : AIDSLINE MED/95186050; Makrydimas G; Plachouras N; Higueras MT; Thilaganathan B; Nicolaides K; Harris Birthright Research Centre for Fetal Medicine, King's; College Hospital School of Medicine, London, UK.; Flow cytometry was used to determine lymphocyte subpopulations in maternal blood from 143 pathological pregnancies: 50 with fetal aneuploidy; 32 with missed abortions; 12 with ectopic pregnancies; 20 with multi-fetal pregnancies, and 29 with pregnancies complicated by intrauterine growth retardation (IUGR). The values
Cytokines, inflammation, and brain injury: role of tumor necrosis factor-alpha.: Cerebrovasc Brain Metab Rev. 1994 Winter;6(4):341-60. Unique Identifier : AIDSLINE MED/95186357; Feuerstein GZ; Liu T; Barone FC; Department of Cardiovascular Pharmacology, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406.; The cytokine tumor necrosis factor (TNF-alpha) is a pleotrophic polypeptide that plays a significant role in brain immune and inflammatory activities. TNF-alpha is produced in the brain in response to various pathological processes such as infectious agents [e.g., human immunodeficiency virus (HIV) and malaria], ische
In vivo evidence that ultraviolet B-induced suppression of allergic contact sensitivity is associated with functional inactivation of Th1 cells.: Photodermatol Photoimmunol Photomed. 1994 Oct;10(5):206-11. Unique Identifier : AIDSLINE MED/95186405; Simon JC; Mosmann T; Edelbaum D; Schopf E; Bergstresser PR; Cruz PD Jr; Department of Dermatology, University of Freiburg, Germany.; Having previously shown in vitro that ultraviolet B (UVB)-treated Langerhans cells (LC) can induce antigen-specific proliferative unresponsiveness and tolerance in Th1 (but not Th2) cells, we wanted to determine whether cutaneous exposure to UVB radiation prior to hapten-painting would produce similar differential eff
Design and synthesis of nonpeptide peptidomimetic inhibitors of renin.: Biopolymers. 1995;37(1):29-53. Unique Identifier : AIDSLINE MED/95186651; Smith AB 3rd; Akaishi R; Jones DR; Keenan TP; Guzman MC; Holcomb RC; Sprengeler PA; Wood JL; Hirschmann R; Holloway MK; Department of Chemistry, University of Pennsylvania, Philadelphia; 19104.; The desire to replace the amide backbone of renin inhibitors with a new scaffold led us to explore vinylogous amides (enaminones). An initial attempt proved unsuccessful, a result explained after the fact via docking experiments. Based on this lesson, we designed a different vinylogous amide scaffold which incorporate
Case 6--1994. Video-assisted thorascopic surgery using a single-lumen tube in spontaneously ventilating anesthetized patients: an alternative anesthetic technique [clinical conference]: J Cardiothorac Vasc Anesth. 1994 Dec;8(6):693-8. Unique Identifier : AIDSLINE MED/95186691; Robinson RJ; Slinger P; Mulder DS; Shennib H; Benumof JL; Rehder K; Department of Anaesthesia, Montreal General Hospital, Quebec,; Canada.
Modeling defective interfering virus therapy for AIDS: conditions for DIV survival.: Math Biosci. 1995 Feb;125(2):127-53. Unique Identifier : AIDSLINE MED/95186899; Nelson GW; Perelson AS; Los Alamos National Laboratory, New Mexico 87545.; The administration of a genetically engineered defective interfering virus (DIV) that interferes with HIV-1 replication has been proposed as a therapy for HIV-1 infection and AIDS. The proposed interfering virus, which is designed to superinfect HIV-1 infected cells, carries ribozymes that cleave conserved regions in
Human T-cell lymphotropic virus, type I (HTLV-I) reported in British Columbia.: Can Commun Dis Rep. 1995 Feb 15;21(3):21-2. Unique Identifier : AIDSLINE MED/95187120; Martin D; Mathias R; Wortman J; Medical Services Branch, University of British Columbia,; Vancouver.
Helping AIDS sufferers at home [interview by Teresa O'Connor]: Nurs N Z. 1994 Dec-1995 Jan;2(11):24-5. Unique Identifier : AIDSLINE MED/95187227; Gore C
[Epidemiological support in blood surveillance]: Transfus Clin Biol. 1994;1(6):421-4. Unique Identifier : AIDSLINE MED/95187342; Salmi LR; Departement d'informatique medicale, Universite de Bordeaux; II.; Hemovigilance is a continuous and standardized system for data collection and analysis, and diffusion of results to clinical and public health decision makers. This system has different objectives than clinical and epidemiological research on labile blood products. A published study of characteristics of donors that a
Pneumocystis carinii pneumonia: a major complication of immunosuppressive therapy in patients with Wegener's granulomatosis [see comments]: Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):795-9. Unique Identifier : AIDSLINE MED/95187435; Ognibene FP; Shelhamer JH; Hoffman GS; Kerr GS; Reda D; Fauci AS; Leavitt RY; Department of Critical Care Medicine, Warren G. Magnuson Clinical; Center, National Institutes of Health, Bethesda, Maryland; 20892-1662.; The risk factors and clinical and laboratory parameters in Pneumocystis carinii pneumonia in patients with Wegener s granulomatosis have not been well characterized. We undertook a retrospective chart review of all patients with a diagnosis of Wegener s granulomatosis and P. carinii pneumonia who were followed at the
Two-stage tuberculin skin testing in individuals with human immunodeficiency virus infection. Community Programs for Clinical Research on AIDS.: Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):805-8. Unique Identifier : AIDSLINE MED/95187437; Webster CT; Gordin FM; Matts JP; Korvick JA; Miller C; Muth K; Brown LS; Besch CL; Kumi JO; Salveson C; et al; Richmond AIDS Consortium, Virginia 23298-0049.; In this study we estimated occurrence of the booster effect in a population infected with the human immunodeficiency virus (HIV) and assessed the relation between the booster effect, T-lymphocyte CD4 cell counts, tuberculosis risk categories, and HIV exposure categories. Patients were recruited from 13 participating s
Laparotomy in patients infected with human immunodeficiency virus: indications and outcome [letter; comment]: Br J Surg. 1995 Jan;82(1):136. Unique Identifier : AIDSLINE MED/95187740; Vieira FM; Lomas M; Vilarino MR
Surgical management of thoracic manifestations in human immunodeficiency virus-positive patients: indications and results.: Br J Surg. 1995 Jan;82(1):39-43. Unique Identifier : AIDSLINE MED/95187757; Mouroux J; Riquet M; Padovani B; Debesse B; Richelme H; Service de Chirurgie Abdominale et Thoracique, Hopital Pasteur,; Nice, France.; The records of 97 patients with thoracic complications of human immunodeficiency virus (HIV) were analysed to determine the reasons for surgery and the results of these procedures. Of the patients, 79 underwent surgery; the remaining 18 were managed non-surgically. A total of 36 procedures were performed for diagnosti
HIV and AIDS: a family approach to care [see comments]: Paediatr Nurs. 1994 Dec;6(10):18-21. Unique Identifier : AIDSLINE MED/95187898; Mackenzie H
HIV and AIDS: when care is for the whole family [editorial; comment]: Paediatr Nurs. 1994 Dec;6(10):3. Unique Identifier : AIDSLINE MED/95187902; Rogers R
Localized or systemic in vivo heat inactivation of human immunodeficiency virus (HIV): a mathematical analysis [see comments]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):321-9. Unique Identifier : AIDSLINE MED/95187912; Pennypacker C; Perelson AS; Nys N; Nelson G; Sessler DI; Lawrence Berkeley Laboratory, University of California 94720.; Temperatures > or = 42 degrees C, maintained for > or = 25 min, inactivate approximately 25% of human immunodeficiency virus (HIV). HIV-infected T cells are more sensitive to heat than healthy lymphocytes, and susceptibility increases when the cells are presensitized by exposure to tumor necrosis factor. Thus, inducti
Functional analysis of the vpx, vpr, and nef genes of simian immunodeficiency virus.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):335-44. Unique Identifier : AIDSLINE MED/95187914; Park IW; Sodroski J; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, Massachusetts.; The role of the vpx, vpr, and nef genes in the replication of simian immunodeficiency virus (SIV) was investigated using point and deletion mutations in these genes. The effects on replication kinetics of single or combined mutants--vpx, vpr, vpx-vpr, vpx-nef, vpr-nef, and vpx-vpr-nef--in established lymphoid CEMx174
Reconsidering the use of adjunctive corticosteroids in Pneumocystis pneumonia? [editorial; comment]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):345-7. Unique Identifier : AIDSLINE MED/95187915; Bozzette SA; Morton SC
A multicenter randomized double-blind placebo-controlled trial of adjunctive corticosteroids in the treatment of Pneumocystis carinii pneumonia complicating the acquired immune deficiency syndrome [see comments]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):348-57. Unique Identifier : AIDSLINE MED/95187916; Walmsley S; Levinton C; Brunton J; Muradali D; Rappaport D; Bast M; Spence D; Salit I; Department of Medicine, Toronto Hospital, Ontario, Canada.; A multicenter placebo-controlled trial of early short-term high-dose methylprednisolone enrolled 78 patients with moderate to severe Pneumocystis carinii pneumonia (PCP) complicating HIV infection. The mean pressure of oxygen (PO2) at study entry was 55 mm Hg for the 71 patients who had blood gases monitored while bre
Early and prolonged decrease of viremia in HIV-1-infected patients treated with didanosine.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):358-64. Unique Identifier : AIDSLINE MED/95187917; Yerly S; Kaiser L; Baumberger C; Hirschel B; Perrin LH; Central Laboratory of Virology, Geneva University Hospital,; Switzerland.; Fourteen patients previously treated with zidovudine were monitored for laboratory parameters and clinical events during 1 year after introduction of didanosine (ddI) monotherapy. Proviral human immunodeficiency virus type 1 (HIV-1) copy numbers (cell-associated DNA) and concentration of free virions (viremia) were de
Hospital admissions of HIV-infected patients from 1988 to 1992 in Maryland.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):365-72. Unique Identifier : AIDSLINE MED/95187918; Fortgang IS; Moore RD; Johns Hopkins University School of Medicine, Baltimore, Maryland.; To determine how the patterns of inpatient hospital care for HIV-infected patients have evolved in recent years, we analyzed data obtained from a statewide hospital discharge database from Maryland for the years 1988, 1990, and 1992. For each of these years, we compared demography, diagnoses, lengths of stay, use of t
The learning curve for AIDS-related Pneumocystis carinii pneumonia: experience from 3,981 cases in Veterans Affairs Hospitals 1987-1991.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):373-8. Unique Identifier : AIDSLINE MED/95187919; Bennett CL; Adams J; Bennett RL; Rodrique D; George L; Cassileth B; Gilman SC; Division of Health Services Research, Durham Veterans; Administration Hospital, Durham, North Carolina.; Previous studies have found lower mortality rates for AIDS-related Pneumocystis carinii pneumonia (PCP) in hospitals with higher levels of experience with PCP. It is not known if patients are selectively referred to better hospitals or if there is a learning curve whereby outcomes improve as physicians gain experience
Identification of a clonal form of HIV in early Kaposi's sarcoma: evidence for a novel model of oncogenesis, sequential neoplasia.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):379-85. Unique Identifier : AIDSLINE MED/95187920; McGrath MS; Shiramizu BT; Herndier BG; Department of Laboratory Medicine, San Francisco General; Hospital, CA 94110.; We recently reported clonal human immunodeficiency virus (HIV involvement in four acquired immune deficiency syndrome (AIDS)-associated non-B-cell lymphoproliferations. In three of these cases HIV expression was localized to tumor-associated macrophages. Because one of the cases had a major component involved in angio
CD4+ lymphocyte count in African patients co-infected with HIV and tuberculosis [see comments]: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):386-91. Unique Identifier : AIDSLINE MED/95187921; Martin DJ; Sim JG; Sole GJ; Rymer L; Shalekoff S; van Niekerk AB; Becker P; Weilbach CN; Iwanik J; Keddy K; et al; MRC AIDS Virus Research Unit, National Institute for Virology,; Sandringham, South Africa.; The objectives of this study were (a) to compare the CD4+ lymphocyte profiles over time of two groups of patients hospitalized for tuberculosis (TB) treatment [a group of patients with TB only (TB group) and a group dually infected by HIV and TB (HIV/TB group)] and (b) to assess the usefulness of the total lymphocyte
Potential and actual workdays lost among patients with HIV.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):392-8. Unique Identifier : AIDSLINE MED/95187922; Leigh JP; Lubeck DP; Farnham P; Fries JF; Department of Economics, San Jose State University, CA; 95192-0114.; How many more potential and actual workdays are lost by HIV patients than persons without HIV? To answer this question, we assessed differences in the number of workdays among a panel of AIDS patients, patients who were HIV positive but did not yet have AIDS, and comparison patients. The patients included persons who
HIV in injecting drug users in Edinburgh: prevalence and correlates.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):399-405. Unique Identifier : AIDSLINE MED/95187923; Davies AG; Dominy NJ; Peters A; Bath GE; Burns SM; Richardson AM; Ward 14A, City Hospital, Edinburgh, Scotland.; A citywide sample of injecting drug users (IDUs) who had injected in the previous 6 months was recruited in Edinburgh. Interviewers administered a questionnaire enquiring about drug use, sharing of injecting equipment, sexual behavior, and imprisonment. A specimen of saliva was assayed for human immunodeficiency virus
Comparison of partner notification at anonymous and confidential HIV test sites in Colorado.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):406-10. Unique Identifier : AIDSLINE MED/95187924; Hoffman RE; Spencer NE; Miller LA; Colorado Department of Public Health and Environment, Denver; 80222-1530.; We compared health department-initiated partner notification at a single anonymous human immunodeficiency virus (HIV) test site in Denver to 13 confidential HIV test sites throughout Colorado over an 18-month period. The average number of named, notified, and counseled in-state partners was from 30 to 50% greater amon
Multisite evaluation of four anti-HIV-1/HIV-2 enzyme immunoassays. Australian HIV Test Evaluation Group.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):411-9. Unique Identifier : AIDSLINE MED/95187925; Silvester C; Healey DS; Cunningham P; Dax EM; National HIV Reference Laboratory, Fairfield Hospital, Victoria,; Australia.; The performance of four enzyme immunoassays, manufactured by Abbott, Diagnostics Pasteur, Genetic Systems, and Organon Teknika, for the combined detection of anti-human immunodeficiency virus type 1 (HIV-1) and anti-HIV-2, was examined in a multisite evaluation. The collaborative efforts of 7 Australian Red Cross Bloo
Risk factors for maternal HTLV-I infection in French Guiana: high HTLV-I prevalence in the Noir Marron population.: J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 1;8(4):420-5. Unique Identifier : AIDSLINE MED/95187926; Tuppin P; Lepere JF; Carles G; Ureta-Vidal A; Gerard Y; Peneau C; Tortevoye P; de The G; Moreau JP; Gessain A; Unite d'Epidemiologie des Virus Oncogenes, Institut Pasteur,; Paris, France.; The aim of this study was to compare rates of human T-cell lymphotropic virus type I (HTLV-I) seroprevalence in pregnant women belonging to different ethnic groups in French Guiana and to determine the risk factors associated with H
[Genetically controlled pharmacomodulation: application to the treatment of HIV infection]: C R Acad Sci III. 1994 Nov;317(11):1027-30. Unique Identifier : AIDSLINE MED/95187956; Caruso M; Klatzmann D; Laboratoire de Biologie et Genetique des Infections; Retrovirales, URA CNRS D1463, CERVI, Hopital; Pitie-Salpetriere, Paris, France.; AZT is an inhibitor of HIV reverse transcriptase which active form is AZT-triphosphate. Its clinical efficacy is limited by its toxicity and the emergence of mutant resistant viruses. This might be due to an unfficient cellular metabolism of AZT which
SCID-Hu mouse as a model for human lung HIV-1 infection.: C R Acad Sci III. 1994 Jul;317(7):669-74. Unique Identifier : AIDSLINE MED/95187969; Cesbron JY; Agut H; Gosselin B; Candotti D; Raphael M; Puech F; Grandadam M; Debre P; Capron A; Autran B; INSERM U. 415, Institut Pasteur, Lille, France.; HIV induces a multi-organ infection with a dual tropism for both lymphocytes and monocytes/macrophages. The lung is a target both for HIV infection and HIV-related opportunistic infections. The SCID mouse has provided the opportunity to develop a small animal model for HIV infection. However, HIV-1 infection of the hu
Antilactoferrin autoantibodies associated with HIV infection.: C R Acad Sci III. 1994 Jul;317(7):675-8. Unique Identifier : AIDSLINE MED/95187970; Defer MC; Follezou JY; Picard O; Damais C; INSERM U. 313, CHU Pitie-Salpetriere, Paris, France.; Sera from 85 HIV-infected patients were tested for the presence of antilactoferrin antibodies (anti-LF Abs) by specific ELISA. Fifty-seven sera were found positive, including sera from asymptomatic (18/28, 64.3%, mean O.D.: 0.27 +/- 0.05) and symptomatic patients (39/57, 68.4%, mean O.D.: 0.82 +/- 0.15). In the contro
Localized brain proton MRS metabolic patterns in HIV-related encephalopathies.: C R Acad Sci III. 1994 Sep;317(9):833-40. Unique Identifier : AIDSLINE MED/95187984; Vion-Dury J; Confort-Gouny S; Nicoli F; Dhiver C; Gastaut JA; Gastaut JL; Cozzone PJ; Centre de Resonance Magnetique Biologique et Medicale (CRMBM),; URA CNRS 1186, Faculte de Medecine, Marseille, France.; We have examined 9 healthy volunteers and 63 HIV-patients (16 asymptomatic patients and 47 patients with clinical AIDS- dementia complex, ADC) by magnetic resonance spectroscopy (MRS) and imaging (MRI) on a Siemens Magnetom SP63 (1.5 T). Proton MRS of the brain was performed at 63 M
HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization.: Immunity. 1994 Aug;1(5):373-84. Unique Identifier : AIDSLINE MED/95187990; Baur AS; Sawai ET; Dazin P; Fantl WJ; Cheng-Mayer C; Peterlin BM; Howard Hughes Medical Institute, Department of Medicine, San; Francisco, California.; Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells. To reconcile these observations, we expressed a hybrid CD8-Nef protein in Jurkat cells. Two opposite phenotypes were found, which depe
Discrimination between thymic epithelial cells and peripheral antigen-presenting cells in the induction of immature T cell differentiation.: Immunity. 1994 Aug;1(5):385-91. Unique Identifier : AIDSLINE MED/95187991; Poirier G; Lo D; Reilly CR; Kaye J; Department of Immunology, Scripps Research Institute, La Jolla,; California 92037.; During their intrathymic migration, immature CD4+ CD8+ thymocytes that express a TCR able to recognize the expressed MHC molecules are positively selected, i.e., complete their differentiation program and become mature T cells. Using the immature CD4+CD8+ T cell line DPK, which can be induced to differentiate in cultu
Kaposi's sarcoma of internal organs. A multiparameter study of 86 cases.: Cancer. 1995 Mar 15;75(6):1376-85. Unique Identifier : AIDSLINE MED/95188120; Ioachim HL; Adsay V; Giancotti FR; Dorsett B; Melamed J; Department of Pathology, Lenox Hill Hospital, New York University; School of Medicine, New York 10021.; BACKGROUND. During the past decade, Kaposi s sarcoma (KS), one of the most common acquired immune deficiency syndrome-defining diseases, has been the subject of sustained research. However, basic questions about its etiology, histogenesis, growth, and dissemination remain unanswered. Even its nature, whether hyperplas
Variable-region sequences for T-cell receptor-gamma and -delta chains of rabbit killer cell lines against Shope carcinoma cells.: Cancer Lett. 1995 Feb 10;89(1):37-44. Unique Identifier : AIDSLINE GENBANK/D38121; Kim CJ; Isono T; Tomoyoshi T; Seto A; Department of Microbiology, Shiga University of Medical Science,; Japan.; A rabbit gamma delta killer T-cell line against Shope carcinoma cells was established from peripheral blood lymphocytes (PBL) of a human T-lymphotropic virus type I (HTLV-I)-infected rabbit bearing Shope papilloma and carcinoma. Southern hybridization analysis of this cell line with an HTLV-I probe showed that the cel
The induction of bacillus-Calmette-Guerin-activated killer cells requires the presence of monocytes and T-helper type-1 cells.: Cancer Immunol Immunother. 1995 Feb;40(2):103-8. Unique Identifier : AIDSLINE MED/95188221; Thanhauser A; Bohle A; Schneider B; Reiling N; Mattern T; Ernst M; Flad HD; Ulmer AJ; Department of Immunology and Cell Biology, Forschungsinstitut; Borstel, Germany.; Previously we have described the induction of MHC-unrestricted killer cells against bladder tumour cells by bacillus Calmette-Guerin (BCG), termed BCG-activated killer (BAK) cells. In the present paper we deal with the accessory-cell requirement for the activation of BAK cells. We show that monocytes are required for
Haematologic features of the human immunodeficiency virus (HIV) infection in Black children in Harare.: Cent Afr J Med. 1994 Dec;40(12):333-6. Unique Identifier : AIDSLINE MED/95188255; Adewuyi J; Chitsike I; Department of Haematology, University of Zimbabwe.; Forty six Black Zimbabwean children aged between three months and seven years who were admitted into Parirenyatwa Central Hospital with serologically positive and symptomatic HIV infection were investigated for their haematologic profiles. Tests done included full blood counts, manual white cell differential counts, c
Oligoclonal activation of CD4+ T lymphocytes in posterior uveitis.: Clin Exp Immunol. 1995 Mar;99(3):412-8. Unique Identifier : AIDSLINE MED/95188420; Feron EJ; Calder VL; Lightman SL; Department of Clinical Ophthalmology, Institute of Ophthalmology,; London, UK.; Several lines of evidence support an important role for activated T lymphocytes in the perpetuation of autoimmune intraocular inflammatory disease (posterior uveitis). In this study peripheral blood lymphocytes (PBL) were examined by three-colour flow cytometry to assess the distribution of
Antibodies to the Cryptococcus neoformans capsular glucuronoxylomannan are ubiquitous in serum from HIV+ and HIV- individuals.: Clin Exp Immunol. 1995 Mar;99(3):425-32. Unique Identifier : AIDSLINE MED/95188422; Deshaw M; Pirofski LA; Department of Medicine, Albert Einstein College of Medicine,; Bronx, NY.; Murine MoAbs to the Cryptococcus neoformans capsular glucuronoxylomannan (GXM) polysaccharide are protective in mice in vivo and in vitro. The prevalence of protective anti-GXM antibodies in human serum is unknown. To provide further insight into the human antibody response to C. neoformans we determined the prevalenc
In vitro production of cytokines by peripheral blood mononuclear cells from hydatid patients.: Clin Exp Immunol. 1995 Mar;99(3):433-9. Unique Identifier : AIDSLINE MED/95188423; Rigano R; Profumo E; Di Felice G; Ortona E; Teggi A; Siracusano A; Laboratorio di Immunologia, Instituto Superiore di Sanita, Rome,; Italy.; The role of cytokines in human hydatidosis (Echinococcus granulosus infection) was evaluated in immunoassays determining production of IL-4, IL-10 and interferon-gamma (IFN-gamma) in peripheral blood mononuclear cell (PBMC) cultures from 30 hydatid patients and 14 uninfected controls. In cell cultures from hydatid pat
Summary of the workshop on passive immunotherapy in the prevention and treatment of HIV infection. The Passive Antibody Workshop Participants.: Clin Immunol Immunopathol. 1995 Apr;75(1):84-93. Unique Identifier : AIDSLINE MED/95188458; Stiehm ER; Mofenson L; Zolla-Pazner S; Jackson B; Martin NL; Ammann AJ
AIDS [letter]: Community Dent Oral Epidemiol. 1994 Dec;22(6):467. Unique Identifier : AIDSLINE MED/95188533; Line SR; Caracante IL; Ayres MT; Almeida OP
[Fluconazole in oro-pharyngeal candidiasis in retroviral infection (experience in Dakar)]: Dakar Med. 1993;38(1):85-8. Unique Identifier : AIDSLINE MED/95188725; Sow PS; Diop BM; Ndiaye I; Faye MA; Coll-Seck AM; Service des Maladies Infectieuses, CHU de Fann, Dakar.; Oral candidiasis is a frequent opportunistic infection in AIDS patients. High risk of dissemination and frequent relapses are common. The autors in Dakar at the Infectious Diseases Department Fann Hospital conduct an open non randomized trial with Fluconazole for the treatment of oral candidiasis in HIV seropositive p
[Ocular manifestations of AIDS in Dakar]: Dakar Med. 1993;38(1):97-100. Unique Identifier : AIDSLINE MED/95188728; Ndoye NB; Sow PS; Ba EA; Ndiaye MR; Wade A; Coll-Seck AM; Clinique Ophtalmologique CHU Le Dantec, Dakar.; In this prospective study undertaken between november 1989 and december 1991, the authors report their observations of ocular lesions seen in a cohort of 67 AIDS patients hospitalised in the Infectious Diseases department CHU Fann Dakar. Ocular lesions were discovered in 52.23%. These lesions were observed in both HIV
Results of the NIDA treatment demonstration grants' cocaine workgroup: characteristics of cocaine users and HIV risk behaviors.: Drug Alcohol Depend. 1995 Jan;37(1):1-6. Unique Identifier : AIDSLINE MED/95188737; Compton WM; Lamb RJ; Fletcher BW; Department of Psychiatry, Washington University School of; Medicine, St. Louis, MO.; This journal issue includes seven articles (six plus this introduction) from the cocaine workgroup of the National Institute on Drug Abuse (NIDA) treatment demonstration grants. In this introduction, results of the first attempts to compare data from seven disparate demonstration grant sites are summarized: Overall, r
Cocaine and crack use and HIV risk behaviors among high-risk methadone maintenance clients.: Drug Alcohol Depend. 1995 Jan;37(1):15-21. Unique Identifier : AIDSLINE MED/95188738; Grella CE; Anglin MD; Wugalter SE; UCLA Drug Abuse Research Center, Neuropsychiatric Institute; 90024.; A discriminant function analysis was performed with data from 409 high-risk heroin addicts at intake into a methadone maintenance treatment program to determine the characteristics of cocaine users. Cocaine users presented a higher-risk profile for human immunodeficiency virus (HIV), engaged in a wider variety of crim
HIV risks, gender, and cocaine use among opiate users.: Drug Alcohol Depend. 1995 Jan;37(1):23-8. Unique Identifier : AIDSLINE MED/95188739; Joe GW; Simpson DD; Institute of Behavioral Research, Texas Christian University,; Fort Worth 76129.; HIV risks involving injection and sex behaviors were analyzed in relation to cocaine use and gender among 487 opiate-dependent clients in methadone treatment. Those who also used cocaine were at greater risk than non-cocaine users on HIV risky injection variables. Females were at more risk than males on the HIV risky
Cocaine use and HIV risk behavior in methadone maintenance patients.: Drug Alcohol Depend. 1995 Jan;37(1):29-35. Unique Identifier : AIDSLINE MED/95188740; Bux DA; Lamb RJ; Iguchi MY; Medical College of Pennsylvania, Department of Psychiatry,; Philadelphia.; This study examined sexual and drug use behavior in 247 methadone maintenance patients, to explore the association of cocaine use with human immunodeficiency virus (HIV) risk behavior. In univariate analyses, cocaine use was positively associated with any drug injection, number of injections, and sexual intercourse wi
Is antisocial personality disorder associated with increased HIV risk behaviors in cocaine users?: Drug Alcohol Depend. 1995 Jan;37(1):37-43. Unique Identifier : AIDSLINE MED/95188741; Compton WM; Cottler LB; Shillington AM; Price RK; Department of Psychiatry, Washington University School of; Medicine, St. Louis, MO 63110.; Previous reports have shown antisocial personality disorder (ASPD) to be strongly associated with injection equipment sharing and increased rates of human immunodeficiency virus (HIV) infection in a sample of heroin injectors. Another report has shown ASPD to be associated with injection drug use, needle sharing, sexu
Therapeutic community methods in methadone maintenance (Passages): an open clinical trial.: Drug Alcohol Depend. 1995 Jan;37(1):45-57. Unique Identifier : AIDSLINE MED/95188742; De Leon G; Staines GL; Perlis TE; Sacks S; McKendrick K; Hilton R; Brady R; Center for Therapeutic Community Research at National Development; and Research Institutes, Inc., New York, NY.; A non-random open clinical trial was conducted to determine whether a day-treatment program based on modified therapeutic community (TC) methods (Passages) produced better treatment outcomes for heroin addicts than did standard methadone maintenance therapy. Altogether, 327 methadone clients at two clinic sites were s
Cocaine use and risky injection and sexual behaviors.: Drug Alcohol Depend. 1995 Jan;37(1):7-14. Unique Identifier : AIDSLINE MED/95188744; Hudgins R; McCusker J; Stoddard A; University of Massachusetts AIDS Research Unit, School of Public; Health, University of Massachusetts, Amherst.; The association between cocaine use (crack and injection cocaine) and risky behaviors for human immunodeficiency virus (HIV) infection was investigated among participants in a multi-site study at drug treatment and non-drug treatment sites in Worcester, Massachusetts. Cocaine use was more prevalent among young, Africa
Proteolytic processing of particle-associated retroviral polyproteins by homologous and heterologous viral proteinases.: Eur J Biochem. 1995 Feb 15;228(1):191-8. Unique Identifier : AIDSLINE MED/95188905; Konvalinka J; Heuser AM; Hruskova-Heidingsfeldova O; Vogt VM; Sedlacek J; Strop P; Krausslich HG; Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; Retroviral proteinase(PR)-catalyzed cleavage of the viral Gag and Gag-Pol polyproteins within the nascent virus particle is required for productive viral infection. Kinetic characterization and specificity analyses have been reported for several retroviral PR using oligopeptide substrates. In this study, we performed
Instability of R3 response of the blink reflex in patients with HAM/TSP.: Funct Neurol. 1994 Jul-Aug;9(4):199-202. Unique Identifier : AIDSLINE MED/95189124; Leon FE; Arimura K; Sonoda Y; Arimura Y; Osame M; Third Department of Internal Medicine, Kagoshima University; School of Medicine, Japan.; HAM/TSP patients presenting interneuronal hyperexcitability of the brainstem displayed the R3 response with closed eyes but this was either diminished or disappeared contralaterally to the stimulation side when they were tested with their eyes open. Lack of regulation of the interneuronal network between R1 and R3 cou
Functional defect of T cells in autoimmune gastritis.: Gut. 1995 Feb;36(2):171-5. Unique Identifier : AIDSLINE MED/95189129; Vargas JA; Alvarez-Mon M; Manzano L; Albillos A; Fernandez-Corugedo A; Albarran F; Durantez A; Department of Medicine, Clinica Puerta de Hierro, Universidad; Autonoma, Madrid, Spain.; The functional response and phenotypic characterisation of peripheral blood T cells were studied in 41 patients with autoimmune gastritis--nine patients with autoimmune gastritis alone, 11 with untreated pernicious anaemia, and 21 with resolved pernicious anaemia who were taking vitamin B-12. Phenotypic analysis showe
Natural history and prognosis of diarrhoea of unknown cause in patients with acquired immunodeficiency syndrome (AIDS).: Gut. 1995 Feb;36(2):283-6. Unique Identifier : AIDSLINE MED/95189149; Blanshard C; Gazzard BG; Chelsea and Westminster Hospital, London.; This paper is a prospective study of patients with advanced human immunodeficiency virus infection and chronic diarrhoea for which no cause could be found after extensive investigations, including examination of multiple stool specimens for all known faecal pathogens and the histological examination of small and large
Increasing prevalence of human immunodeficiency virus infection among patients attending a clinic for sexually transmitted diseases.: Indian J Med Res. 1995 Jan;101:6-9. Unique Identifier : AIDSLINE MED/95189220; Jacob M; John TJ; George S; Rao PS; Babu PG; Department of Dermatology, Christian Medical College & Hospital,; Vellore.; Of 5883 patients screened during 1986 to 1993 in the sexually transmitted diseases (STD) clinic at a hospital in Vellore, south India , 105 (1.79%) were positive for human immunodeficiency virus (HIV) antibody. The prevalence of HIV infection increased from 0.26 per cent in 1986 to 2
Effects of aerobic exercise training on lymphocyte subpopulations.: Int J Sports Med. 1994 Oct;15 Suppl 3:S127-30. Unique Identifier : AIDSLINE MED/95189332; LaPerriere A; Antoni MH; Ironson G; Perry A; McCabe P; Klimas N; Helder L; Schneiderman N; Fletcher MA; Department of Psychiatry, University of Miami, Florida.; This study was conducted to determine the effects of an aerobic exercise training program on subpopulations of lymphocyte phenotypes. Fourteen healthy but sedentary males, 18-40 years of age, were randomly assigned to either an aerobic exercise training or control condition. Aerobic exercise training consisted of thre
Recruitment and recirculation of leukocytes after an ultramarathon run: preferential homing of cells expressing high levels of the adhesion molecule LFA-1.: Int J Sports Med. 1994 Oct;15 Suppl 3:S148-53. Unique Identifier : AIDSLINE MED/95189335; Gabriel H; Brechtel L; Urhausen A; Kindermann W; Institute of Sports and Performance Medicine, University of; Saarland, Saarbrucken.; The alpha L beta 2 (CD11a/CD18) integrin LFA-1 (lymphocyte function-associated antigen-1) mainly contributes to the firm arrest of leucocytes on the endothelium. Its cell surface density is thought to be important for the exercise-induced homing of leucocytes. 9 athletes (7 males, 2 females, age 36-68 years, body mass
[Antiretroviral therapy in adult HIV-infected patients]: Internist (Berl). 1994 Dec;35(12):1095-104. Unique Identifier : AIDSLINE MED/95189455; Salzberger B; Schrappe M; Diehl V; Klinik I fur Innere Medizin, Universitatsklinik Koln.
Kaposi's sarcoma of the oral cavity in a non-AIDS patient: case report and review of the literature.: Head Neck. 1995 Jan-Feb;17(1):64-8. Unique Identifier : AIDSLINE MED/95189502; Jindal JR; Campbell BH; Ward TO; Almagro US; Department of Otolaryngology, Medical College of Wisconsin,; Milwaukee 53226.; BACKGROUND. Not every patient with Kaposi s sarcoma (KS) has acquired immunodeficiency syndrome (AIDS). The classic form of KS is rare, and is associated with an indolent course. It is very distinct from AIDS-associated KS in which oral involvement is common and may be the initial presenting feature of this disease. T
Increased interleukin-6 (IL-6) production in a young child with clinical and pathologic features of multicentric Castleman's disease.: J Clin Immunol. 1994 Nov;14(6):382-90. Unique Identifier : AIDSLINE MED/95189906; Kinney MC; Hummell DS; Villiger PM; Hourigan A; Rollins-Smith L; Glick AD; Lawton AR; Department of Pathology, Vanderbilt University Medical Center,; Nashville, Tennessee 37232.; A 21-month-old boy presented with a papular rash, lymphoadenopathy, and splenomegaly. He developed symmetric polyarthritis, fever, and progressive glomerulonephritis. Serologies for viral agents including HIV were negative. Antinuclear antibody was transiently positive, but no anti-DNA antibodies were present. CH50 an
Helicobacter sp. strain Mainz isolated from an AIDS patient with septic arthritis: case report and nonradioactive analysis of 16S rRNA sequence.: J Clin Microbiol. 1994 Dec;32(12):3037-9. Unique Identifier : AIDSLINE GENBANK/X81028; Husmann M; Gries C; Jehnichen P; Woelfel T; Gerken G; Ludwig W; Bhakdi S; Institute of Medical Microbiology and Hygiene, University of; Mainz, Federal Republic of Germany.; A campylobacter-like organism was isolated from an effusion of the left knee joint of an AIDS patient 2 weeks after bacteremia with a morphologically identical organism. Amplified genomic 16S rRNA sequences were analyzed by a nonradioactive blotting technique. The closest match was found with Helicobacter fenelliae (9
Preliminary results of Pneumocystis carinii strain differentiation by using molecular biology.: J Clin Microbiol. 1994 Dec;32(12):3052-3. Unique Identifier : AIDSLINE GENBANK/S77852; Latouche S; Roux P; Poirot JL; Lavrard I; Hermelin B; Bertrand V; Laboratoire de Parasitologie-Mycologie, Centre Hospitalier; Universitaire Saint-Antoine, Paris, France.; The mode of Pneumocystis carinii transmission is controversial. Recent studies point to exogenous inoculation rather than reactivation, and person-to-person transmission has also been suggested. Comparison of nucleotide sequences of the large-subunit mitochondrial rRNA gene of P. carinii from human immunodeficiency vi
Optimization of quantitative culture assay for human immunodeficiency virus from plasma. Plasma Viremia Group Laboratories of the AIDS Clinical Trials Group (National Institute of Allergy and Infectious Diseases).: J Clin Microbiol. 1994 Dec;32(12):3064-7. Unique Identifier : AIDSLINE MED/95189947; Lathey JL; Fiscus SA; Rasheed S; Kappes JC; Griffith BP; Elbeik T; Spector SA; Reichelderfer PS; Department of Pediatrics, University of California, San Diego, La; Jolla 92093.; Experimental conditions essential to a simple, reproducible, quantitative human immunodeficiency virus plasma assay were determined. Five parameters were evaluated: length of culture, reproducibility, assay dilution schema, washing procedures, and anticoagulant usage. The recommended quantitative plasma assay utilizes
Bordetella bronchiseptica in an AIDS patient cross-reacts with Legionella antisera [letter]: J Clin Microbiol. 1994 Dec;32(12):3095-6. Unique Identifier : AIDSLINE MED/95189959; Jimenez-Lucho V; Shulman M; Johnson J
AIDS knowledge, occupational precautions, and public education activities among law enforcement officers and first responders.: J Public Health Policy. 1994 Winter;15(4):460-9. Unique Identifier : AIDSLINE MED/95189991; Gellert GA; Maxwell RM; Higgins KV; Barnard R; Page B; Project HOPE, Health Sciences Education Center, Millwood, VA; 22646.; A survey on AIDS was administered within a large, southern California jurisdiction to law enforcement officers and first responders (paramedics, firefighters). Respondents had accurate knowledge about AIDS but several incorrect perceptions about HIV transmission; a substantial proportion believed that HIV could be con
Risk of human immunodeficiency virus infection for emergency department workers. Italian Study Group on Occupational Risk of HIV Infection.: J Emerg Med. 1994 Nov-Dec;12(6):737-44. Unique Identifier : AIDSLINE MED/95190260; De Carli G; Puro V; Binkin NJ; Ippolito G; Coordinating Center: Unita' Operativa AIDS, L. Spallanzani; Hospital, Rome, Italy.; To evaluate the risk of human immunodeficiency virus (HIV) exposure among emergency department workers (EDWs) and their ability to identify HIV-infected patients, a seroprevalence study was performed in March 1991 in the emergency departments (EDs) of six Italian urban hospitals. At each visit, patients aged 18-65 yea
The management of sharps in the emergency department: is it safe?: J Emerg Med. 1994 Nov-Dec;12(6):745-52. Unique Identifier : AIDSLINE MED/95190261; Moss ST; Clark RF; Guss DA; Rosen P; Department of Emergency Medicine, University of California, San; Diego.; In this study, we observed the management of sharps by health care workers including physicians, nurses, technicians, and students in the Emergency Department of the University of California-San Diego Medical Center. Twenty-eight percent of 418 observed sharp utilizations were managed in such a way that excess risk wa
Human T-cell lymphotrophic virus type-I (HTLV-I) retrovirus and human disease.: J Emerg Med. 1994 Nov-Dec;12(6):825-32. Unique Identifier : AIDSLINE MED/95190273; Bentrem DJ; McGovern EE; Hammarskjold ML; Edlich RF; Department of Plastic Surgery, University of Virginia School of; Medicine, Charlottesville 22908.; Human T-cell lymphotrophic virus type-I (HTLV-I) was the first pathogenic retrovirus identified in humans. HTLV-I is now linked to a number of clinical diseases, most notably adult T-cell leukemia/lymphoma and the syndrome known as HTLV-associated myelopathy or tropical spastic paraparesis (HAM/TSP). For the emergency
Hepatitis C virus infection in sexually active homosexual men.: J Infect. 1994 Nov;29(3):263-9. Unique Identifier : AIDSLINE MED/95190295; Buchbinder SP; Katz MH; Hessol NA; Liu J; O'Malley PM; Alter MJ; AIDS Office, Department of Public Health, San Francisco, CA; 94102-6033.; While hepatitis C virus (HCV) is known to be transmitted parenterally, the role of sexual transmission remains unclear. In order to examine the association of sexual risk factors with HCV seroprevalence at a time when unprotected sexual practices were still quite common, 435 homosexual men recruited from a municipal s
Serum concentrations of soluble intercellular adhesion molecule-1 and progress towards disease in patients infected with HIV.: J Infect. 1994 Nov;29(3):271-82. Unique Identifier : AIDSLINE MED/95190296; Sipsas N; Sfikakis PP; Sfikakis P; Choremi H; Kordossis T; Department of Pathologic Physiology, Athens University School of; Medicine, Laikon Hospital, Greece.; Intercellular adhesion molecule-1 (ICAM-1) is a membrane-bound molecule that is primarily involved in cell to cell adhesive interactions of the immune system. Concentrations of soluble ICAM-1 (s-ICAM-1) shed into the circulation were measured by a quantitative ELISA in HIV-infected persons without AIDS, patients with
Barnett Christie Lecture (1993). The natural history of HIV infection: a study in Edinburgh drug users.: J Infect. 1994 Nov;29(3):311-21. Unique Identifier : AIDSLINE MED/95190301; Flegg PJ; Regional Infectious Diseases Unit, City Hospital, Edinburgh, U.K.
Mycoplasma fermentans and HIV-associated nephropathy.: J Infect. 1994 Nov;29(3):323-6. Unique Identifier : AIDSLINE MED/95190302; Ainsworth JG; Katseni V; Hourshid S; Waldron S; Ball S; Cattell V; Taylor-Robinson D; MRC Sexually Transmitted Disease Research Group, St Mary's; Hospital Medical School, Paddington, London, U.K.; We describe a patient in whom HIV-associated nephropathy developed in association with the detection of Mycoplasma fermentans. This mycoplasma was found in renal tissue by means of a polymerase chain reaction when nephropathy was first evident, and subsequently in urine, blood and the throat. The evidence presented st
Stomatococcus mucilaginosus lower respiratory tract infection in a patient with AIDS.: J Infect. 1994 Nov;29(3):327-30. Unique Identifier : AIDSLINE MED/95190303; Cunniffe JG; Mallia C; Alcock PA; Public Health Laboratory, Central Pathology Laboratory,; Hartshill, Stoke-on-Trent, U.K.; We describe a case of recurrent Stomatococcus mucilaginosus lower respiratory tract infection in a patient with AIDS. Apart from S. mucilaginosus no other pathogens were found to account for infection. There was a rapid response to rifampicin, the organism being resistant to penicillin, co-trimoxazole and ciprofloxaci
Cytomegalovirus encephalitis in two patients with AIDS receiving ganciclovir for cytomegalovirus retinitis [see comments]: J Infect. 1994 Nov;29(3):331-7. Unique Identifier : AIDSLINE MED/95190304; Mastroianni CM; Ciardi M; Folgori F; Sebastiani G; Vullo V; Delia S; Sorice F; Department of Infectious and Tropical Diseases, La Sapienza; University, Rome, Italy.; Cytomegalovirus ( CMV ) encephalitis has been reported with increasing frequency in patients with AIDS. Nevertheless, the management of CMV-related encephalitis appears to be problematic and data in the literature on the clinical efficacy of ganciclovir therapy is
Morganella morganii meningitis in a patient with AIDS [letter]: J Infect. 1994 Nov;29(3):356-7. Unique Identifier : AIDSLINE MED/95190309; Mastroianni A; Coronado O; Chiodo F
Synergism between interferon-gamma and cytokines or lipopolysaccharide in the activation of the HIV-LTR in macrophages.: J Leukoc Biol. 1995 Mar;57(3):469-76. Unique Identifier : AIDSLINE MED/95190403; Warfel AH; Thorbecke GJ; Belsito DV; Department of Dermatology, New York University School of; Medicine, New York.; Macrophages (mos) obtained from transgenic mice carrying the HIV long terminal repeat-chloramphenicol acetyl transferase (LTR-CAT) sequence were used to study the influence of various biologic response modifiers (BRMs) on the activation of LTR-directed CAT expression. It was found that LPS or IL-6 alone induced modera
Psychological functioning and substance abuse before and after the 1992 Los Angeles riot in a community sample of women.: J Psychoactive Drugs. 1994 Oct-Dec;26(4):431-7. Unique Identifier : AIDSLINE MED/95190705; Brown VB; Melchior LA; Reback C; Huba GJ; PROTOTYPES, Culver City, California 90230.; An ongoing study of interventions designed to increase nontraditional social supports among women at high risk for HIV infection was in the field during the 1992 Los Angeles riot in those neighborhoods most affected by the urban unrest. Using data from structured interviews, the psychosocial characteristics, drug abus
[Evaluation of medication costs in hospitalization of AIDS patients]: J Pharm Belg. 1994 Nov-Dec;49(6):479-97. Unique Identifier : AIDSLINE MED/95190740; Somme V; Flori A; Bouchet B; Bues-Charbit M; Balansard G; Gallais H; Pharmacie Hopital Nord, Marseille.; The aim of this study was to examine the global pharmaceutical cost of AIDS patients hospitalized in a ward of infectious diseases in Marseille. They were 209 patients at various clinical stages of HIV infection receiving or not AZT or another specifi
What are some of the issues facing the mental health nurse in providing care to the clients who are HIV-positive or who have AIDS?: J Psychosoc Nurs Ment Health Serv. 1994 Nov;32(11):47-51. Unique Identifier : AIDSLINE MED/95190798; Smith GB; Ripich S; Adult Psychiatric Services, Tampa General Hospital University; Psychiatric Center, Florida.
Adolescent HIV prevention campaign established [news]: J Psychosoc Nurs Ment Health Serv. 1994 Nov;32(11):54. Unique Identifier : AIDSLINE MED/95190799
Characterization of an infectious molecular clone of human T-cell leukemia virus type I.: J Virol. 1995 Apr;69(4):2024-30. Unique Identifier : AIDSLINE GENBANK/L03561; Zhao TM; Robinson MA; Bowers FS; Kindt TJ; Laboratory of Immunogenetics, NIAID Twinbrook II Facility,; Rockville, Maryland 20852.; An infectious molecular clone of human T-cell leukemia virus type I (HTLV-I) was derived from an HTLV-I-transformed rabbit T-cell line, RH/K30, obtained by coculture of rabbit peripheral blood mononuclear cells (PBMC) with the human HTLV-I-transformed cell line MT-2. The RH/K30 cell line contained two integrated provi
Molecular and biological analyses of quasispecies during evolution of a virulent simian immunodeficiency virus, SIVsmmPBj14.: J Virol. 1995 Apr;69(4):2031-7. Unique Identifier : AIDSLINE MED/95190971; Tao B; Fultz PN; Department of Microbiology, University of Alabama at Birmingham; 35294.; A prototypic simian immunodeficiency virus (SIVsmm9), isolated from a naturally infected sooty mangabey (Cercocebus atys), was passaged in vivo in a pig-tailed macaque (Macaca nemestrina) having the identifier PBj. When PBj died of a typical AIDS-like syndrome 14 months after infection, the virus isolated from its tis
Human immunodeficiency virus type 1 Vif- mutant particles from restrictive cells: role of Vif in correct particle assembly and infectivity.: J Virol. 1995 Apr;69(4):2058-67. Unique Identifier : AIDSLINE MED/95190974; Borman AM; Quillent C; Charneau P; Dauguet C; Clavel F; Unite d'Oncologie Virale, CNRS URA 1157, Departement Sida et; Retrovirus, Institut Pasteur, Paris, France.; Disruption of the vif gene of human immunodeficiency virus (HIV) type 1 affects virus infectivity to various degrees, depending on the T-cell line used. We have concentrated our studies on true phenotypic Vif- mutant particles produced from CEMx174 or H9 cells. In a single round of infection, Vif- virus is approximate
Peripheral blood mononuclear cells produce normal amounts of defective Vif- human immunodeficiency virus type 1 particles which are restricted for the preretrotranscription steps.: J Virol. 1995 Apr;69(4):2068-74. Unique Identifier : AIDSLINE MED/95190975; Courcoul M; Patience C; Rey F; Blanc D; Harmache A; Sire J; Vigne R; Spire B; INSERM U372, 13276 Marseille, France.; Previous studies have demonstrated the absence of viral replication of Vif- mutants in stimulated primary blood mononuclear cells (PBMC). Human immunodeficiency virus type 1 strain NDK Vif- mutants were propagated on the semipermissive CEM cell line, and the viral stock obtained was compared with the wild-type virus d
Changes in the viral mRNA expression pattern correlate with a rapid rate of CD4+ T-cell number decline in human immunodeficiency virus type 1-infected individuals.: J Virol. 1995 Apr;69(4):2092-2100. Unique Identifier : AIDSLINE MED/95190978; Furtado MR; Kingsley LA; Wolinsky SM; Department of Pathology, Northwestern University Medical School,; Chicago, Illinois 60611.; The rate of disease progression varies considerably among human immunodeficiency virus type 1 (HIV-1)-infected individuals. Several cross-sectional studies have shown an association between the stage of HIV-1 disease and the viral burden or the relative levels of viral gene expression. To study the extent of HIV-1 tra
RNA secondary structure and binding sites for gag gene products in the 5' packaging signal of human immunodeficiency virus type 1.: J Virol. 1995 Apr;69(4):2101-9. Unique Identifier : AIDSLINE MED/95190979; Clever J; Sassetti C; Parslow TG; Department of Pathology, University of California, San Francisco; 94143-0506.; The selective encapsidation of retroviral RNA requires sequences in the Gag protein, as well as a cis-acting RNA packaging signal (psi site) near the 5 end of the genomic transcript. Gag protein of human immunodeficiency virus type 1 (HIV-1) has recently been found to bind specifically to the HIV-1 psi element in vit
Structural analysis of the principal immunodominant domain of the feline immunodeficiency virus transmembrane glycoprotein.: J Virol. 1995 Apr;69(4):2110-8. Unique Identifier : AIDSLINE MED/95190980; Pancino G; Camoin L; Sonigo P; Genetique des Virus et Immunopharmacologie Moleculaire; (ICGM-CNRS UPR0415), Institut Cochin de Genetique Moleculaire,; Paris, France.; In the transmembrane envelope glycoprotein (TM) of lentiviruses, including human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus (FIV), two cysteine residues, conserved in most retroviruses, are thought to form a loop containing five to seven amino acids. These elements make up a B-cell epitope
Replication of macrophage-tropic and T-cell-tropic strains of human immunodeficiency virus type 1 is augmented by macrophage-endothelial cell contact.: J Virol. 1995 Apr;69(4):2133-9. Unique Identifier : AIDSLINE MED/95190983; Gilles PN; Lathey JL; Spector SA; Department of Pediatrics, University of California, San Diego, La; Jolla 92093-0672.; Macrophages perform a central role in the pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection and have been implicated as the cell type most prominent in the development of central nervous system impairment. In this study, we evaluated the effect of interaction between macrophages and endothelial cel
Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor.: J Virol. 1995 Apr;69(4):2148-52. Unique Identifier : AIDSLINE MED/95190985; Patick AK; Rose R; Greytok J; Bechtold CM; Hermsmeier MA; Chen PT; Barrish JC; Zahler R; Colonno RJ; Lin PF; Department of Virology, Bristol-Myers Squibb Pharmaceutical; Research Institute, Wallingford, Connecticut 06492.; Development of viral resistance to the aminodiol human immunodeficiency virus (HIV) protease inhibitor BMS 186,318 was studied by serial passage of HIV type 1 RF in MT-2 cells in the presence of increasing concentrations of compound. After 11 passages, an HIV variant that showed a 15-fold increase in 50% effective dos
Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function.: J Virol. 1995 Apr;69(4):2159-67. Unique Identifier : AIDSLINE GENBANK/L31963; Neumann M; Felber BK; Kleinschmidt A; Froese B; Erfle V; Pavlakis GN; Brack-Werner R; GSF-Institute of Molecular Virology, Oberschleissheim, Germany.; Chronically human immunodeficiency virus type 1 (HIV-1) strain IIIB-infected human TH4-7-5 astrocytoma cells show low-level virus production. Cocultivation of TH4-7-5 cells with myelomonocytic cells led to active virus production in these target cells after a lag period, indicating cell-determined restriction of virus
Secondary structure model of the Mason-Pfizer monkey virus 5' leader sequence: identification of a structural motif common to a variety of retroviruses.: J Virol. 1995 Apr;69(4):2175-86. Unique Identifier : AIDSLINE MED/95190989; Harrison GP; Hunter E; Lever AM; Department of Medicine, Addenbrooke's Hospital, University of; Cambridge, United Kingdom.; A stable secondary structure model is presented for the region 3 of the primer-binding site to 130 bases into the gag sequence of the prototype type D retrovirus Mason- Pfizer monkey virus. Using biochemical probing of RNA from this region in association with free energy m
An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors.: J Virol. 1995 Apr;69(4):2214-22. Unique Identifier : AIDSLINE MED/95190993; Berlioz C; Darlix JL; LaboRetro, Unite de Virologie Humaine (INSERM-ENS U412), Ecole; Normale Superieure de Lyon, France.; The genomic retroviral RNA is the messenger for the translation of the gag and pol genes encoding the precursors to the major structural proteins and enzymes, respectively, of the virion core. The long 5 untranslated region, the leader, is formed of independent well-structured domains involved in key steps of the vir
Interactions between human immunodeficiency virus type 1 and human cytomegalovirus in human term syncytiotrophoblast cells coinfected with both viruses.: J Virol. 1995 Apr;69(4):2223-32. Unique Identifier : AIDSLINE MED/95190994; Toth FD; Mosborg-Petersen P; Kiss J; Aboagye-Mathiesen G; Hager H; Juhl CB; Gergely L; Zdravkovic M; Aranyosi J; Lampe L; et al; Department of Virus and Cancer, Danish Cancer Society, Aarhus.; Human cytomegalovirus (HCMV) and human immunodeficiency virus type 1 (HIV-1) may interact in the pathogenesis of AIDS. The placental syncytiotrophoblast layer serves as the first line of defense of the fetus against viruses. We analyzed the patterns of replication of HIV-1 and HCMV
Mediation of human immunodeficiency virus type 1 binding by interaction of cell surface heparan sulfate proteoglycans with the V3 region of envelope gp120-gp41.: J Virol. 1995 Apr;69(4):2233-9. Unique Identifier : AIDSLINE MED/95190995; Roderiquez G; Oravecz T; Yanagishita M; Bou-Habib DC; Mostowski H; Norcross MA; Division of Hematologic Products, Food and Drug Administration,; Bethesda, Maryland 20892.; The mechanism of heparan sulfate (HS)-mediated human immunodeficiency virus type 1 (HIV-1) binding to and infection of T cells was investigated with a clone (H9h) of the T-cell line H9 selected on the basis of its high level of cell surface CD4 expression. Semiquantitative PCR analysis revealed that enzymatic removal
A vaccine-elicited, single viral epitope-specific cytotoxic T lymphocyte response does not protect against intravenous, cell-free simian immunodeficiency virus challenge.: J Virol. 1995 Apr;69(4):2279-84. Unique Identifier : AIDSLINE MED/95191001; Yasutomi Y; Koenig S; Woods RM; Madsen J; Wassef NM; Alving CR; Klein HJ; Nolan TE; Boots LJ; Kessler JA; et al; Harvard Medical School, Beth Israel Hospital, Boston,; Massachusetts 02215.; Protection against simian immunodeficiency virus (SIV) challenge was assessed in rhesus monkeys with a vaccine-elicited, single SIV epitope-specific cytotoxic T-lymphocyte (CTL) response in the absence of SIV-specific antibody. Strategies were first explored for eliciting an optimal SIV Gag epitope-specific CTL respon
Similarity in env and gag genes between genomic RNAs of human immunodeficiency virus type 1 (HIV-1) from mother and infant is unrelated to time of HIV-1 RNA positivity in the child.: J Virol. 1995 Apr;69(4):2285-96. Unique Identifier : AIDSLINE +; Mulder-Kampinga GA; Simonon A; Kuiken CL; Dekker J; Scherpbier HJ; van de Perre P; Boer K; Goudsmit J; Human Retrovirus Laboratory, Academic Medical Center, Amsterdam,; The Netherlands.; Variation in the env (V3 region) and gag (p17 region) genes of genomic RNA of human immunodeficiency virus type 1 was studied in three mother-child pairs. One infant was human immunodeficiency virus type 1 RNA positive at birth (pair 114), one became positive 6 weeks after birth (pair 127), and one became positive 30
Intraspecific phylogenetics: support for dental transmission of human immunodeficiency virus.: J Virol. 1995 Apr;69(4):2351-6. Unique Identifier : AIDSLINE MED/95191010; Crandall KA; Department of Zoology, University of Texas at Austin 78712-1064.; A new method to estimate within-species gene genealogies was used to establish linkages among individuals associated with the Florida dental human immunodeficiency virus transmission case. Phylogenetic relationships were estimated from 103 nucleotide sequences from the V3 region of the env gene representing the Florid
Sequence requirements for encapsidation of deletion mutants and chimeras of human immunodeficiency virus type 1 Gag precursor into retrovirus-like particles.: J Virol. 1995 Apr;69(4):2366-77. Unique Identifier : AIDSLINE MED/95191012; Carriere C; Gay B; Chazal N; Morin N; Boulanger P; Faculte de Medecine, Laboratoire de Virologie et Pathogenese; Moleculaires (CNRS URA-1487), Montpellier, France.; Interacting domains in human immunodeficiency virus type 1 (HIV-1) Gag precursor (Pr55gag) expressed in recombinant baculovirus-infected cells were investigated by three different methods: (i) trans rescue and coencapsidation of C-terminal deletion (amber) Gag mutants and Gag chimeras into retrovirus-like particles in
Progression to AIDS in the absence of a gene for vpr or vpx.: J Virol. 1995 Apr;69(4):2378-83. Unique Identifier : AIDSLINE MED/95191013; Gibbs JS; Lackner AA; Lang SM; Simon MA; Sehgal PK; Daniel MD; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, Massachusetts 01772-9102.; Rhesus monkeys (Macaca mulatta) were experimentally infected with strains of simian immunodeficiency virus (SIV) derived from SIVmac239 lacking vpr, vpx, or both vpr and vpx genes. These auxiliary genes are not required for virus replication in cultured cells but are consistently conserved within the SIVmac/human immu
Inhibition of apoptosis in human immunodeficiency virus-infected cells enhances virus production and facilitates persistent infection.: J Virol. 1995 Apr;69(4):2384-92. Unique Identifier : AIDSLINE MED/95191014; Antoni BA; Sabbatini P; Rabson AB; White E; Laboratory of Viral Pathogenesis, Center for Advanced; Biotechnology and Medicine, Piscataway, New Jersey.; Apoptosis is one of several mechanisms by which human immunodeficiency virus type 1 (HIV-1) exerts its cytopathic effects. CD4+ Jurkat T-cell lines overexpressing the adenovirus E1B 19K protein, a potent inhibitor of apoptosis, were used to examine the consequences of inhibition of apoptosis during acute and chronic H
Increased adhesion as a mechanism of antibody-dependent and antibody-independent complement-mediated enhancement of human immunodeficiency virus infection.: J Virol. 1995 Apr;69(4):2393-400. Unique Identifier : AIDSLINE MED/95191015; Lund O; Hansen J; Soorensen AM; Mosekilde E; Nielsen JO; Hansen JE; Physics Department, Technical University of Denmark, Lyngby.; Enhancement of human immunodeficiency virus (HIV) infection by complement alone or in conjunction with antibodies was studied experimentally and theoretically. Experimental studies showed that while HIV-positive sera neutralize HIV infection, the addition of fresh complement abrogated neutralization and could even cau
Chimeras of receptors for gibbon ape leukemia virus/feline leukemia virus B and amphotropic murine leukemia virus reveal different modes of receptor recognition by retrovirus.: J Virol. 1995 Apr;69(4):2401-5. Unique Identifier : AIDSLINE MED/95191016; Pedersen L; Johann SV; van Zeijl M; Pedersen FS; O'Hara B; Lederle Laboratories, American Cyanamid Company, Pearl River, New; York 10965.; Glvr1 encodes the human receptor for gibbon ape leukemia virus (GALV) and feline leukemia virus subgroup B (FeLV-B), while the related gene Glvr2 encodes the human receptor for amphotropic murine leukemia viruses (A-MLVs). The two proteins are 62% identical in their amino acid sequences and are predicted to have 10 tr
Chimeras from a human rhinovirus 14-human immunodeficiency virus type 1 (HIV-1) V3 loop seroprevalence library induce neutralizing responses against HIV-1.: J Virol. 1995 Apr;69(4):2406-11. Unique Identifier : AIDSLINE MED/95191017; Resnick DA; Smith AD; Gesiler SC; Zhang A; Arnold E; Arnold GF; Center for Advanced Biotechnology and Medicine, Rutgers; University, Piscataway, New Jersey 08854.; A chimeric virus library was designed whereby sequences corresponding to the V3 loop of human immunodeficiency virus type 1 (HIV-1) were presented on the surface of human rhinovirus 14. The V3 loop sequences consisted of a relatively conserved segment of seven amino acids and five adjacent residues that were allowed t
The majority of cells are superinfected in a cloned cell line that produces high levels of human immunodeficiency virus type 1 strain MN.: J Virol. 1995 Apr;69(4):2443-50. Unique Identifier : AIDSLINE MED/95191022; Ott DE; Nigida SM Jr; Henderson LE; Arthur LO; AIDS Vaccine Program, Program Resources Inc./DynCorp, National; Cancer Institute, Frederick Cancer Research and Development; Center, Maryland 21702-1201.; We have isolated seven single-cell clones from an H9 culture infected with human immunodeficiency virus type 1 strain MN so that a stable producer of virus could be obtained. DNAs from these clones were examined by Southern blot analysis and found to contain between one and four proviruses per clone. One of these cell
Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions.: J Virol. 1995 Apr;69(4):2451-61. Unique Identifier : AIDSLINE MED/95191023; Billich A; Hammerschmid F; Peichl P; Wenger R; Zenke G; Quesniaux V; Rosenwirth B; Sandoz Forschungsinstitut GmbH, Vienna, Austria.; Cyclosporins, in particular the nonimmunosuppressive derivative SDZ NIM 811, exhibit potent anti-human immunodeficiency virus type 1 (HIV-1) activity in vitro. SDZ NIM 811 interferes at two stages of the viral replication cycle: (i) translocation of the preintegration complex to the nucleus and (ii) production of infe
Effect of cellular differentiation on cytokine-induced expression of human immunodeficiency virus in chronically infected promonocytic cells: dissociation of cellular differentiation and viral expression.: J Virol. 1995 Apr;69(4):2540-6. Unique Identifier : AIDSLINE MED/95191034; Goletti D; Kinter AL; Biswas P; Bende SM; Poli G; Fauci AS; National Institute of Allergy and Infectious Diseases, Bethesda,; Maryland 20892.; Cellular differentiation is thought to play an important role in the susceptibility of monocytic lineage cells to human immunodeficiency virus (HIV) infection as well as in their ability to support virus replication. In addition, virus replication in monocytes/macrophages has been demonstrated in vitro to be strongly
Conservation of an intact human immunodeficiency virus type 1 vif gene in vitro and in vivo.: J Virol. 1995 Apr;69(4):2557-64. Unique Identifier : AIDSLINE MED/95191036; Sova P; van Ranst M; Gupta P; Balachandran R; Chao W; Itescu S; McKinley G; Volsky DJ; Molecular Virology Laboratory, St. Luke's-Roosevelt Hospital; Center, New York, New York 10019.; Replication of vif-negative human immunodeficiency virus type 1 (HIV-1) is attenuated in certain cell lines and highly impaired in peripheral blood lymphocytes in vitro. To determine whether intact vif is positively selected during natural HIV-1 infection and to determine vif sequence variability, we employed PCR ampl
Delineating minimal protein domains and promoter elements for transcriptional activation by lentivirus Tat proteins.: J Virol. 1995 Apr;69(4):2605-10. Unique Identifier : AIDSLINE MED/95191042; Southgate CD; Green MR; Howard Hughes Medical Institute, Program in Molecular Medicine,; University of Massachusetts Medical Center 01605.; Lentivirus Tat proteins comprise a novel class of RNA-binding transcriptional activators that are essential for viral replication. In this study, we performed a series of protein fusion experiments to delineate the minimal protein domains and promoter elements required for Tat action. We show that a 15-amino-acid regi
Tax mutation associated with tropical spastic paraparesis/human T-cell leukemia virus type I-associated myelopathy [published erratum appears in J Virol 1995 Jun;69(6):3964] [see comments]: J Virol. 1995 Apr;69(4):2611-6. Unique Identifier : AIDSLINE MED/95191043; Renjifo B; Borrero I; Essex M; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115.; Tumaco, Colombia , is an area with elevated rates of tropical spastic paraparesis/human T-cell leukemia virus type I (HTLV-I)-associated myelopathy (TSP/HAM). We have identified a mutation in nucleotide 7959 of the tax gene of 14 Tum
Simian AIDS type D serogroup 2 retrovirus: isolation of an infectious molecular clone and sequence analyses of its envelope glycoprotein gene and 3' long terminal repeat.: J Virol. 1995 Apr;69(4):2621-8. Unique Identifier : AIDSLINE GENBANK/L38695; Marracci GH; Kelley RD; Pilcher KY; Crabtree L; Shiigi SM; Avery N; Leo G; Webb MC; Hallick LM; Axthelm MK; et al; Division of Primate Medicine, Oregon Regional Primate Research; Center, Oregon Health Sciences University, Beaverton 97006.; We describe the molecular cloning of a serogroup 2 simian retrovirus (SRV; D2/RHE/OR) and present the sequence of its envelope (env) glycoprotein gene and 3 long terminal repeat region. This report documents the first infectious molecular clone of a serogroup 2 SRV and provides env sequence verification of genetic di
The human immunodeficiency virus type 1 Tat antagonist, Ro 5-3335, predominantly inhibits transcription initiation from the viral promoter.: J Virol. 1995 Apr;69(4):2640-3. Unique Identifier : AIDSLINE MED/95191049; Cupelli LA; Hsu MC; Roche Research Center, Hoffmann-La Roche, Inc., Nutley, New; Jersey 07110.; Tat, the transcriptional transactivator protein of the human immunodeficiency virus type 1 (HIV-1), is required for viral replication in vitro. The Tat antagonist, Ro 5-3335, and its analog, Ro 24-7429, have been shown to inhibit replication of HIV-1 and to reduce steady-state viral RNA in infected cells (M.-C. Hsu et
Retroviral vector particles displaying the antigen-binding site of an antibody enable cell-type-specific gene transfer.: J Virol. 1995 Apr;69(4):2659-63. Unique Identifier : AIDSLINE MED/95191053; Chu TH; Dornburg R; Department of Molecular Genetics and Microbiology, Robert Wood; Johnson Medical School, University of Medicine and Dentistry of; New Jersey, Piscataway 08854.; Retroviral vectors are the most efficient tool for stably introducing genes into vertebrate cells. However, their use is limited by the host range of the retrovirus from which they are derived. To alter the host range, we recently constructed retrovirus vector particles, derived from spleen necrosis virus, that displa
Sequence diversity of V1 and V2 domains of gp120 from human immunodeficiency virus type 1: lack of correlation with viral phenotype.: J Virol. 1995 Apr;69(4):2708-15. Unique Identifier : AIDSLINE +; Wang N; Zhu T; Ho DD; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016.; We analyzed by PCR and direct sequencing 57 viral sequences from 47 individuals infected with human immunodeficiency virus type 1, focussing on the V1 and V2 regions of gp120. There was extensive length polymorphism in the V1 region, which rendered sequence alignment difficult. The V2 hypervariable locus also displaye
Home testing kits for HIV apt to get FDA approval [news]: JAMA. 1995 Mar 22-29;273(12):908-9. Unique Identifier : AIDSLINE MED/95191070; Marwick C
Crucial antibody response [news]: JAMA. 1995 Mar 22-29;273(12):910. Unique Identifier : AIDSLINE MED/95191072; Voelker R
Lessons from cat virus [news]: JAMA. 1995 Mar 22-29;273(12):910. Unique Identifier : AIDSLINE MED/95191073; Voelker R
A deletion mutant of the LMP1 oncogene of Epstein-Barr virus is associated with evolution of angioimmunoblastic lymphadenopathy into B immunoblastic lymphoma.: Leukemia. 1995 Mar;9(3):458-65. Unique Identifier : AIDSLINE MED/95191186; Knecht H; Martius F; Bachmann E; Hoffman T; Zimmermann DR; Rothenberger S; Sandvej K; Wegmann W; Hurwitz N; Odermatt BF; et al; Department of Internal Medicine, CHUV University Hospital,; Lausanne, Switzerland.; The latent membrane protein 1 (LMP1) oncogene is one of the major proteins synthesized by the Epstein-Barr virus (EBV). It is expressed in Reed-Sternberg cells of Hodgkin s disease (HD), tumor cells of nasopharyngeal carcinoma (NPC), and immunoblasts of angioimmunoblastic lymphadenopathy (AILD). A particular LMP1 dele
Cyclospora: conquest of an emerging pathogen [comment] [see comments]: Lancet. 1995 Mar 18;345(8951):667-8. Unique Identifier : AIDSLINE MED/95191266; Soave R; Johnson WD Jr; Division of Infectious Diseases and International Medicine, New; York Hospital-Cornell Medical Center, New York.
Conjunctival squamous-cell carcinoma associated with HIV infection in Kampala, Uganda [see comments]: Lancet. 1995 Mar 18;345(8951):695-6. Unique Identifier : AIDSLINE MED/95191273; Ateenyi-Agaba C; Department of Ophthalmology, Makerere University Medical School,; Kampala, Uganda.; The incidence of conjunctival squamous-cell carcinoma in Kampala, Uganda , was steady at around 6 per million per year from 1970 until 1988, but has increased six-fold since then to 35 per million per year in 1992. Among 48 patients with conjunctival tumours seen at the ophthalmolog
HIV infection from donor semen [news]: Lancet. 1995 Mar 18;345(8951):719. Unique Identifier : AIDSLINE MED/95191279; Bignall J
Herpesvirus-like DNA sequence in Kaposi's sarcoma from AIDS and non-AIDS patients in Taiwan [letter]: Lancet. 1995 Mar 18;345(8951):722-3. Unique Identifier : AIDSLINE MED/95191285; Su IJ; Hsu YS; Chang YC; Wang IW
[The appearance and progression of the human immunodeficiency virus epidemic in sub-Saharan Africa]: Med Trop (Mars). 1994;54(3):207-10. Unique Identifier : AIDSLINE MED/95191349; Charmot G; LaRoche R; l'Institut de Medecine et d'Epidemiologie Africaines, Paris.
[Aspects of sexually transmissible diseases in young children in Burundi: gonorrhea caused by sexual abuse]: Med Trop (Mars). 1994;54(3):231-3. Unique Identifier : AIDSLINE MED/95191356; Baribwira C; Muteganya D; Ndihokubwayo JB; Moreno JL; Nduwimana M; Rufyikiri T; Departement de Pediatrie, Centre Hospitalier Universitaire; Kamenge, Bujumbura, Burundi.; The purpose of this study was to demonstrate the existence of sexually transmitted diseases secondary to sexual abuse inflicted on young infants in Black Africa. A total of 230 files involving infants presenting leucorrhea or urethral discharge were reviewed in Bujumbura ( Burundi )
[Cardiac involvement in human immunodeficiency virus infection]: Med Trop (Mars). 1994;54(3):253-6. Unique Identifier : AIDSLINE MED/95191362; Moustaghfir A; Touze JE; Service de Pathologie Cardio-vasculaire, Hopitaux des Forces; Armees Royales Marocaines, Marseille, France.
Notification of syringe-sharing and sex partners of HIV-infected persons--Pennsylvania, 1993-1994.: MMWR Morb Mortal Wkly Rep. 1995 Mar 24;44(11):202-4. Unique Identifier : AIDSLINE MED/95191485; In April 1993, a man incarcerated in a prison in Berks County in eastern Pennsylvania voluntarily requested testing for human immunodeficiency virus (HIV) antibody and was diagnosed with HIV infection. Following an interview and counseling by Pennsylvania Department of Health HIV Prevention Program (HIVPP) staff (1),
Co-incidence of HIV/AIDS and tuberculosis--Chicago, 1982-1993.: MMWR Morb Mortal Wkly Rep. 1995 Mar 24;44(11):227-31. Unique Identifier : AIDSLINE MED/95191491; In 1985, the epidemic of human immunodeficiency virus (HIV) infection was recognized as an influence on the increasing occurrence of tuberculosis (TB) in the United States (1). Programs to control and prevent TB require information characterizing the interaction between HIV infection a
[Ways of finding inhibitors of HIV reproduction among nucleotides]: Mol Biol (Mosk). 1994 Nov-Dec;28(6):1245-57. Unique Identifier : AIDSLINE MED/95191524; Kraevskii AA; In spite of continuous broad search for inhibitors of HIV reproduction among new nucleosides, there seems to be a certain crisis in the problem. One of the probable solutions could be based on the investigation of nucleotide and/or nucleoside 5 -triphosphates with modified carbohydrate and phosphate residues. The revi
Increased frequencies of micronuclei in T8 lymphocytes of smokers.: Mutat Res. 1995 Apr;334(2):205-8. Unique Identifier : AIDSLINE MED/95191573; Holmen A; Karlsson A; Bratt I; Hogstedt B; Department of Occupational Medicine, Central Hospital, Halmstad,; Sweden.; Micronucleus frequencies and mitotic indices were analyzed in B, T4, and T8 lymphocytes from 40 smokers and 42 non-smoking referents. The highest level of micronuclei was found in T4 cells followed by T8 and B cells. These differences were statistically significant. There were statistically significant linear correlat
Gene therapy approval may be rocky road for industry [news]: Nature. 1995 Mar 16;374(6519):202. Unique Identifier : AIDSLINE MED/95191637; Gavaghan H
Agency for Health Care Policy and Research releases new guidelines on HIV [news]: Pediatr Nurs. 1994 Jul-Aug;20(4):389. Unique Identifier : AIDSLINE MED/95191963; Rollins JA
Abdominal tuberculosis in children.: Pediatr Radiol. 1994;24(7):473-7. Unique Identifier : AIDSLINE MED/95191988; Ablin DS; Jain KA; Azouz EM; University of California, Davis Medical Center.; Four boys with abdominal tuberculosis, one of whom had acquired immunodeficiency syndrome, are presented. Abdominal imaging findings on plain radiography, ultrasonography, computed tomography, and gastrointestinal contrast studies included tuberculous peritonitis and ascites in all patients, tuberculous adenopathy in
Promoter control of translation in Xenopus oocytes.: Nucleic Acids Res. 1995 Feb 11;23(3):405-12. Unique Identifier : AIDSLINE MED/95192049; Gunkel N; Braddock M; Thorburn AM; Muckenthaler M; Kingsman AJ; Kingsman SM; EMBL, Heidelberg, Germany.; The HIV-1 promoter directs the high level production of transcripts in Xenopus oocytes. However, despite being exported to the cytoplasm, the transcripts are not translated [M. Braddock, A. M. Thorburn, A. Chambers, G. D. Elliott, G. J. Anderson, A. J. Kingsman and S. M. Kingsman (1990) Cell, 62, 1123-1133]. We have s
HIV infection among prison inmates [news]: Nurs Times. 1995 Feb 15-22;91(7):10-1. Unique Identifier : AIDSLINE MED/95192095; Taylor A; Goldberg D; Emslie J
Life-saving chore [news]: Nurs Times. 1995 Feb 15-22;91(7):20. Unique Identifier : AIDSLINE MED/95192099; Turner T
Psychological and emotional impact of an HIV diagnosis.: Nurs Times. 1995 Feb 22-8;91(8):37-9. Unique Identifier : AIDSLINE MED/95192120; Firn S; Norman IJ; This is the first of two papers that reports the results of a research study into the psychological and emotional needs of people with HIV and how nurses might best offer support. This paper discusses the psychological impact of HIV diagnosis. Inductive analysis of indepth interviews with in-patients and their nurses
Midwives' Journal. Maternal HIV transmission [news]: Nurs Times. 1995 Feb 22-8;91(8):67. Unique Identifier : AIDSLINE MED/95192131
Prolonged, but not diminished, zidovudine absorption induced by a high-fat breakfast.: Pharmacotherapy. 1994 Nov-Dec;14(6):671-7. Unique Identifier : AIDSLINE MED/95192186; Shelton MJ; Portmore A; Blum MR; Sadler BM; Reichman RC; Morse GD; Department of Pharmacy Practice, State University of New York at; Buffalo.; STUDY OBJECTIVE. To determine the effect of a high-fat breakfast on single-dose, zidovudine (ZDV) pharmacokinetics. DESIGN. Open-label, randomized, crossover study. PATIENTS. Eighteen asymptomatic subjects (12 men, 6 women) infected with the human immunodeficiency virus (mean CD4 cell counts of 512 +/- 178/mm3). INTER
Proteinase inhibitors: the result of rational drug design. Introduction.: Pharmacotherapy. 1994 Nov-Dec;14(6 Pt 2):1S-2S. Unique Identifier : AIDSLINE MED/95192197; Coleman R
Use of proteinase inhibitors in clinical practice.: Pharmacotherapy. 1994 Nov-Dec;14(6 Pt 2):21S-29S. Unique Identifier : AIDSLINE MED/95192198; Pollard RB; Department of Internal Medicine, University of Texas Medical; Branch, Galveston 77555-0882.; Drugs that are currently available for the treatment of human immunodeficiency virus (HIV) infection, the nucleoside analogs, are limited in their usefulness both by the fact that they all act at the same site of virus replication and because of the development of drug resistance. One of the major areas of HIV researc
Rational drug design: the proteinase inhibitors.: Pharmacotherapy. 1994 Nov-Dec;14(6 Pt 2):9S-20S. Unique Identifier : AIDSLINE MED/95192200; Wlodawer A; Macromolecular Structure Laboratory, National Cancer; Institute-FCRDC, Frederick, Maryland 21702.; Human immunodeficiency virus (HIV) proteinase is a promising target for the rational development of drugs against the acquired immunodeficiency syndrome (AIDS), since this enzyme is necessary for viral maturation, and its inhibition could lead to cessation of viral replication. Rational drug design combines chemical s
[Primary brain lymphoma in acquired immunodeficiency syndrome. Immunophenotype and molecular pathologic characterization in stereotactic biopsy, autopsy and cerebrospinal fluid cytology]: Pathologe. 1995 Jan;16(1):75-80. Unique Identifier : AIDSLINE MED/95192239; Schmitt-Graff A; Hummel M; Anagnostopoulos I; Stoltenburg G; Stein H; Institut fur Pathologie und Neuropathologie,; Universitatsklinikum Benjamin Franklin, Berlin.; In this study we present morphological, cytological, immunophenotypical, and molecular genetic features of ten cases of AIDS-related primary brain lymphomas obtained as sterotactic biopsies, autopsy specimens, or cerebrospinal fluid samples. Histologically, a very characteristic perivascular and diffuse lymphomatous s
Primary health care in South Africa.: Qld Nurse. 1994 Nov-Dec;13(6):16-7. Unique Identifier : AIDSLINE MED/95192484; Playdon M
Clinical use of hematopoietic growth factors.: Rev Invest Clin. 1994 Apr;Suppl:33-40. Unique Identifier : AIDSLINE MED/95192541; Lowenberg B; Dale DC; Sheridan WP
Retroviral diseases in hematology.: Rev Invest Clin. 1994 Apr;Suppl:40-6. Unique Identifier : AIDSLINE MED/95192542; Spivak JL; Henry D; Glaspy J
Non-Hodgkin's lymphoma: treatment of large cell lymphomas.: Rev Invest Clin. 1994 Apr;Suppl:83-8. Unique Identifier : AIDSLINE MED/95192551; Armitage JO; Carde P; Wolf M
Human immunodeficiency virus transmission and surgeons: update.: South Med J. 1995 Mar;88(3):251-5. Unique Identifier : AIDSLINE MED/95192778; Rhodes RS; Department of Surgery, University of Mississippi Medical Center,; Jackson 39216-4505.; Concerns of patients and health care providers regarding disease transmission in the health care setting are not unique to the current human immunodeficiency virus (HIV) epidemic. The data show that the risk to health care workers (HCWs) from patients is far greater than the risk to patients from HCWs. Despite the hig
Brain imaging in AIDS.: South Med J. 1995 Mar;88(3):331-7. Unique Identifier : AIDSLINE MED/95192793; Benson ML; Laine FJ; Department of Radiology, Medical College of Virginia, Richmond.; Although central nervous system (CNS) involvement is common in the population with acquired immunodeficiency syndrome, the presenting neurologic signs and symptoms are often vague and nonfocal. This represents a significant diagnostic challenge for the primary care physician. Cross-sectional imaging now plays an impor
Evaluation of donor self exclusion program.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:130-2. Unique Identifier : AIDSLINE MED/95192817; Chiewsilp P; Kitkornpan S; Stabunswadigan S; Iamsilp W; Suebsaeng C; Department of Pathology, Faculty of Medicine, Ramathibodi; Hospital, Mahidol University, Bangkok, Thailand.; Donor self exclusion is a low technology procedure to avoid blood donations from the high-risk groups for HIV infection. This strategy has been widely used in western countries to reduce the risk of transfusion associated AIDS. At Ramathibodi Hospital, we conducted a study on donor self exclusion program during March-
Six cases of seroconversion of human immunodeficient virus (HIV) antibody post-transfusion in HIV seronegative bloods.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:133-8. Unique Identifier : AIDSLINE MED/95192818; Chaimongkol B; Hirunsri P; Siriloi-ratana P; Department of Medicine, Faculty of Medicine, Chiang Mai; University, Thailand.; Seroconversion of human immunodeficient virus (HIV)-antibody post blood transfusion has been reported (Jett et al, 1983; Cumming et al, 1989). We report here, six hematologic patients who became HIV-antibody positive after receiving HIV seronegative blood and blood components during their illness. There were three cas
Risk of transfusion associated AIDS by seronegative blood in Thailand: a multicenter report.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:139-40. Unique Identifier : AIDSLINE MED/95192819; Chiewsilp P; Isarangkura P; Tanprasert S; Nuchprayoon C; Chaimongkol B; Suvatte V; Kulapongs P; Intragumtornchai T; Department of Pathology, Faculty of Medicine, Ramathibodi; Hospital, Bangkok, Thailand.; Prevention of transfusion associated AIDS (TAA) in Thailand began in 1986 when the HIV infection started to be sharply increased among the general population. The retrospective anti-HIV screening in various blood donor populations by The National Blood Center (NBC) revealed a ser
HIV seroprevalence in hematologic patients other than hemophiliacs at Ramathibodi Hospital.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:187-90. Unique Identifier : AIDSLINE MED/95192833; Mahaphan W; Hathirat P; Isarangkura P; Chuansumrit A; Atnaseo P; Panthangkura W; Chiewsilp P; Department of Pediatrics, Ramathibodi Hospital, Mahidol; University, Bangkok, Thailand.; Recently there have been increasing reports of HIV infection acquired through transfusion of HIV seronegative blood in Thailand due to high incidence of HIV new infection in blood donors. Blood or blood components (BC) prepared from HIV seronegative blood donation pose significan
HIV seroconversion in Thai hemophiliacs up to 1991.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:191-4. Unique Identifier : AIDSLINE MED/95192834; Isarangkura P; Chuansumrit A; Hathirat P; Panthangkura W; Mahaphan W; Limsuwan A; Chiewsilp P; Department of Pediatrics, Faculty of Medicine, Ramathibodi; Hospital, Mahidol University, Bangkok, Thailand.; In Thailand , the anti-HIV screening in the donor blood was started in 1987 and was compulsory nationwide in February 1989. Sixty-six hemophilia A and 10 hemophilia B patients who received approximately six million units of factor VIII and IX in the form of fresh frozen plasma, fr
Plasmapheresis for the preparation of HIV free cryoprecipitate.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:195-7. Unique Identifier : AIDSLINE MED/95192835; Tardtong P; Chuansumrit A; Stabanswadigan S; Chiewsilp P; Isarangkura P; Department of Pathology, Faculty of Medicine, Ramathibodi; Hospital, Mahidol University, Bangkok, Thailand.; Single donor cryoprecipitate was prepared by blood cell separator for treatment of hemophilia A and von Willebrand patients to reduce a risk of transfusion associated HIV infection. A total of 7 plasmapheresis (range 1-1.5 plasma volume) was performed in 4 donors. Then fresh frozen plasma (FFP) was processed to cryopr
The safe blood components for a hemophilia patient: a case report.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:198-200. Unique Identifier : AIDSLINE MED/95192836; Chuansumrit A; Pandhawong S; Tardtong P; Isarangkura P; Department of Pediatrics, Faculty of Medicine, Ramathibodi; Hospital, Mahidol University, Bangkok, Thailand.; This study comments on safe blood components prepared for a 6 year old boy with hemophilia A (F VIII:C 1.8%). He has required blood transfusion since 10 months of age and started home therapy since 3 years of age. The utilized blood components were fresh dry plasma (FDP) prepared from 8-10 selected donors who were in
Surgical orthopedic correction of hemophilic hemarthrosis at Ramathibodi Hospital.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:253-5. Unique Identifier : AIDSLINE MED/95192853; Isarangkura P; Keorochana S; Chuansumrit A; Jitpraphai C; Mahaphan W; Hathirat P; Chiewsilp P; Prachathumrong P; Pintadit P; Panthangkura W; et al; Faculty of Medicine, Ramathibodi Hospital, Mahidol University,; Bangkok, Thailand.; During 1982-1992, 15 major surgical orthopedic correction (SOC) were performed in 12 hemophiliacs. There were 11 synovectomy, 2 osteotomy, 1 currettage and suture wound, 1 release of multiple joint contracture and 1 removal of pseudotumour. During 1982-1989, frozen cryoprecipitate was entirely used for replacement the
Hemophiliacs--a picture from a developing country: Karnataka, a south Indian state.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:270-3. Unique Identifier : AIDSLINE MED/95192859; Kulkarni ML; Nanda G; Karnataka Hemophilic Society, Karnataka, India.; Forty cases of hereditary bleeding disorders, who are the members of Karnataka Hemophilia Society (a State Chapter of the Hemophilia Federation of India ) were studied to learn their problems. Twenty-four cases were thoroughly investigated including factor assay and in 16 cases the d
Anti-HIV, anti-HCV, syphilis, HBsAg serologic tests among high-risk groups and blood donors in Yogyakarta, Indonesia.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:275-7. Unique Identifier : AIDSLINE MED/95192861; Triwibowo; Department of Medicine, Faculty of Medicine University of Gadjah; Mada, Indonesia.; This report showed anti-HIV among high-risk groups and blood donors in Yogyakarta were still negative. The frequency of HBsAg among blood donor was 2% (RPHA), 3% (ELISA) positive. Test for syphilis gave 0.3% positive.
Hemophilia: the changing role of the orthopedic surgeon in the era of HIV infection.: Southeast Asian J Trop Med Public Health. 1993;24 Suppl 1:30-3. Unique Identifier : AIDSLINE MED/95192864; Gilbert MS; International Hemophilia Training Center, Mount Sinai Hospital,; New York.; HIV infection and AIDS have posed additional challenges to the orthopedic surgeon and they are discussed in this paper. The acute hemarthrosis. 1. Undertreatment has resulted in further joint degeneration 2. A hemarthrosis with an unusual pain pattern or an elevated temperature may be a pyarthrosis and aspiration and
A community study of T lymphocyte subsets and malaria parasitaemia.: Trans R Soc Trop Med Hyg. 1994 Nov-Dec;88(6):709-10. Unique Identifier : AIDSLINE MED/95193053; Lisse IM; Aaby P; Whittle H; Knudsen K; Department of Pathology, Hvidovre University Hospital,; Copenhagen, Denmark.; In a community survey of 312 children aged 3-6 years in urban Guinea-Bissau , we examined Plasmodium falciparum parasitaemia and T cell subsets. 183 children (59%) had parasites in their blood, 13 had fever > or = 37.5 degrees C, and 9 (3%) had fever and a parasite density > 5000/m
Predominant infiltration of rejecting human renal allografts with T cells expressing CD8 and CD45RO.: Transplantation. 1995 Mar 15;59(5):724-8. Unique Identifier : AIDSLINE MED/95193073; Ibrahim S; Dawson DV; Sanfilippo F; Department of Pathology, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205-2191.; Subsets of T cells have been identified by the expression of different isoforms of CD45. Some T cells expressing CD45RA (gp220) have been characterized as naive in their response to antigens including alloantigens, whereas T cells expressing CD45RO (gp180) have been characterized as memory T cells. To examine the pote
Rejection of kidney allografts by MHC class I-deficient mice.: Transplantation. 1995 Mar 15;59(5):746-55. Unique Identifier : AIDSLINE MED/95193077; Mannon RB; Nataraj C; Kotzin BL; Griffiths R; Geier S; Ibrahim S; Sanfilippo FP; Platt JL; Kurlander R; Coffman TM; Department of Medicine, Duke University, Durham, North Carolina; 27710.; To evaluate the requirement for CD8+ T cells in kidney transplant rejection, we studied class I-deficient (class I-) mice that had received vascularized renal allografts. Because of the absence of MHC class I expression, these mice are grossly deficient in CD4-CD8+ alpha beta TCR+ cells. Despite the deficiency of CD8+
The contribution of counselling in hospital and home-based care in a small town and surrounding rural area in Zambia.: Trop Doct. 1995 Jan;25(1):21-4. Unique Identifier : AIDSLINE MED/95193099; Jordan IB; Haworth A; Mansa General Hospital, Zambia.
Antimicrobial susceptibility of Neisseria gonorrhoeae, the essential drug list, and HIV/AIDS control [letter]: Trop Doct. 1995 Jan;25(1):45. Unique Identifier : AIDSLINE MED/95193113; Adu-Sarkodie Y
Bacterial meningitis in developing countries.: Trop Doct. 1995 Jan;25(1):5-8. Unique Identifier : AIDSLINE MED/95193117; Wright JP; Ford HL; North Yorkshire Health Authority, UK.
Bovine immunodeficiency virus: incidence of infection in Mississippi dairy cattle.: Vet Microbiol. 1994 Nov;42(2-3):181-9. Unique Identifier : AIDSLINE MED/95193223; St.Cyr Coats K; Pruett SB; Nash JW; Cooper CR; Department of Biological Sciences, Mississippi State University; 39762.; Bovine immunodeficiency virus (BIV), a lentivirus, was originally derived from a Holstein cow with persistent lymphocytosis and severe wasting. The virus is known to occur sporadically throughout the United States and perhaps across the globe, but epidemiological data concerning the in
Bovine leukaemia virus: rapid detection of proviral DNA by nested PCR in blood and organs of experimentally infected calves.: Vet Microbiol. 1994 Nov;42(2-3):191-204. Unique Identifier : AIDSLINE MED/95193224; Klintevall K; Ballagi-Pordany A; Naslund K; Belak S; Department of Virology, National Veterinary Institute, Uppsala,; Sweden.; The early stage of bovine leukaemia virus (BLV) infection was studied in experimentally infected calves in order to assess the diagnostic applicability of a double polymerase chain reaction (PCR). In addition, the kinetics of infection and virus distribution were evaluated. To simulate the natural route of virus trans
A side chain at position 48 of the human immunodeficiency virus type-1 protease flap provides an additional specificity determinant.: Virology. 1995 Mar 10;207(2):475-85. Unique Identifier : AIDSLINE MED/95193246; Moody MD; Pettit SC; Shao W; Everitt L; Loeb DD; Hutchison CA 3rd; Swanstrom R; Lineberger Comprehensive Cancer Center, University of North; Carolina at Chapel Hill 27599.; Substitution of glycine with glutamic acid at position 48 of the human immunodeficiency virus protease resulted in an enzyme with reduced activity on one of the protease processing sites in the viral Pol polyprotein precursor. Cleavage at this site was restored by a second-site substitution in the substrate replacing
Chimeric macaque/human Fab molecules neutralize simian immunodeficiency virus.: Virology. 1995 Mar 10;207(2):495-502. Unique Identifier : AIDSLINE MED/95193248; Samuelsson A; Chiodi F; Ohman P; Putkonen P; Norrby E; Persson MA; Karolinska Institute, Department of Medicine, Rolf Luft's Center,; Karolinska Hospital, Stockholm, Sweden.; A collection of simian immunodeficiency virus (SIV) neutralizing recombinant Fab fragments was generated using the combinatorial antibody library approach. Functional antibody fragments efficiently expressed in Escherichia coli were identified only in the form of chimeric macaque heavy chain gamma 1 and human light ch
Progression to AIDS in macaques is associated with changes in the replication, tropism, and cytopathic properties of the simian immunodeficiency virus variant population.: Virology. 1995 Mar 10;207(2):528-42. Unique Identifier : AIDSLINE GENBANK/M32741; Rudensey LM; Kimata JT; Benveniste RE; Overbaugh J; Department of Microbiology, University of Washington, Seattle; 98195.; Human immunodeficiency virus type 1 (HIV-1) typically evolves from a macrophage-tropic, noncytopathic virus at early asymptomatic stages of infection to a T-cell-tropic, cytopathic, and syncytia-inducing virus population as humans progress to AIDS. This suggests that changes in virus phenotype may influence disease. B
[Transmission of HIV infection]: Wien Klin Wochenschr. 1995;107(3):85-90. Unique Identifier : AIDSLINE MED/95193263; Tomaso H; Reisinger EC; Grasmug E; Ramschak H; Krejs GJ; Medizinische Universitatsklinik der Karl-Franzens-Universitat,; Graz.; The increasing number of human immuno-deficiency virus (HIV) infections and the shift from traditional risk groups to the general population give reason for reviewing the routes and risks of virus transmission. In Africa HIV is transmitted mainly by heterosexual contact; in Europe and the USA homosexuality is still th
HIV-testing of health care workers: unethical request or moral obligation?: Wien Klin Wochenschr. 1995;107(3):91-4. Unique Identifier : AIDSLINE MED/95193264; Allerberger F; Luthe R; Institute of Hygiene, University of Innsbruck.; Transmission of HIV from physician to patient is possible. Physicians should help the public understand the low level of this risk and put it in the perspective of other medical risks, while acknowledging public concern. Nevertheless, there is a clear need for national guidelines which give unambiguous, practicable gu
[Idiopathic CD4+ T-lymphocytopenia in 2 patients without indications for HIV infection]: Wien Klin Wochenschr. 1995;107(3):95-100. Unique Identifier : AIDSLINE MED/95193265; Pohl W; Armbruster C; Bernhardt K; Drlicek M; Vetter N; Medizinische Abteilung, Pulmologisches Zentrum der Stadt Wien.; We report on two patients with idiopathic CD4+ T cell depletion. A 26 year-old woman presented to us with acute respiratory failure requiring mechanical ventilation. Despite combined antibiotic therapy parenterally the opacities increased in the chest X-ray. An open lung biopsy was performed and led to the histologica
Human immunization in developing countries: practical and theoretical problems and prospects.: Vaccine. 1994 Nov;12(15):1423-35. Unique Identifier : AIDSLINE MED/95193318; Arya SC; Centre for Logistical Research & Innovation, New Delhi, India.; While measles, pertussis and tetanus were responsible during the early 1990s for nearly two million deaths in developing countries, no deaths were attributable to them in industrialized countries. More than 96% of global deaths by communicable diseases were also from developing countries. Respiratory infections ranked
Protection of rhesus macaques from SIV infection by immunization with different experimental SIV vaccines.: Vaccine. 1994 Nov;12(15):1443-52. Unique Identifier : AIDSLINE MED/95193320; de Vries P; Heeney JL; Boes J; Dings ME; Hulskotte EG; Dubbes R; Koornstra W; ten Haaft P; Akerblom L; Eriksson S; et al; Laboratory of Immunobiology, National Institute of Public Health; and Environmental Protection, Bilthoven, The Netherlands.; The immunogenicity and efficacy of an inactivated whole SIVmac (32H) preparation adjuvanted with muramyl dipeptide (SIV-MDP) and a gp120-enriched SIVmac (32H) ISCOM preparation (SIV-ISCOM), were compared by immunizing four rhesus macaques (Macaca mulatta) four times with SIV-MDP and four others in the same way with SI
[Liaison programs in drug abuse-AIDS]: Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1994 Nov-Dec;22(6):249-53. Unique Identifier : AIDSLINE MED/95193563; Marin Lozano J; Rubio Valladolid G; Bayon Perez C; Ulibarri Moreno S; Bango Suarez J; Santo-Domingo Carrasco J; Servicio de Psiquiatria, Hospital La Paz, Madrid.; AIDS has acquired a growing importance for psychiatry because of the number of infected people and the increasing attention that these patients need. The major risk group in Spain is the drug users one. These patients share management problems when they are in general hospitals sett
Iron deficiency: the global perspective.: Adv Exp Med Biol. 1994;356:219-28. Unique Identifier : AIDSLINE MED/95193588; Cook JD; Skikne BS; Baynes RD; Department of Medicine University of Kansas Medical Center,; Kansas City 66160-7402.; The prevelance of IDA in industrialized countries has declined in recent decades, but there has been little change in the worldwide prevalence. IDA is currently estimated to affect more than 500 million people. Recent studies have indicated that anemia per se, the most common manifestation of iron deficiency, is less
Urticaria.: Am Fam Physician. 1995 Mar;51(4):811-6. Unique Identifier : AIDSLINE MED/95193726; Mahmood T; UMDNJ-New Jersey Medical School, Newark.; Urticaria (hives) is a common disorder that affects 15 to 20 percent of the population at some time. Lesions are clinically characterized by a transient, pruritic, patchy eruption that consists of lightly erythematous papules or wheals. When attacks are protracted, urticaria is an annoying condition for the patient an
Adult immunizations--a practical approach for clinicians: Part I.: Am Fam Physician. 1995 Mar;51(4):859-67. Unique Identifier : AIDSLINE MED/95193731; Zimmerman RK; Clover RD; Department of Family Medicine, University of Pittsburgh (Pa.); School of Medicine.; Vaccine-preventable diseases cause needless sickness and death in adult Americans. Most adults 65 years of age or older have not been immunized against influenza or pneumococcal disease. In addition to an age of 65 years or older, indications for influenza and pneumococcal vaccines include chronic obstructive pulmonar
Up-regulation of T helper 2 and down-regulation of T helper 1 cytokines during murine retrovirus-induced immunodeficiency syndrome enhances susceptibility of a resistant mouse strain to Leishmania amazonensis.: Am J Pathol. 1995 Mar;146(3):635-42. Unique Identifier : AIDSLINE MED/95193821; Barral-Netto M; da Silva JS; Barral A; Reed S; School of Medicine, Federal University of Bahia, Brazil.; Resistance to and recovery from leishmania infection is dependent on cell-mediated immunity. C57BL/6 mice are resistant to Leishmania amazonensis (La) infection but susceptible to LP-BM5 murine leukemia virus (MuLV) infection. MuLV infection leads to a state of immunodeficiency characterized by severe compromise of ce
AIDS-related Kaposi's sarcoma: evidence for direct stimulatory effect of glucocorticoid on cell proliferation.: Am J Pathol. 1995 Mar;146(3):727-34. Unique Identifier : AIDSLINE MED/95193830; Guo WX; Antakly T; Departement de pathologie, Universite de Montreal, Quebec,; Canada.; Glucocorticoid therapy has been linked to increased risk of development of Kaposi s sarcoma (KS), which has become epidemic among HIV-infected individuals. However, no experimental evidence is available to explain the role of glucocorticoid in KS biopathology. We investigated the direct effect of dexamethasone (Dex) o
Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion.: Ann Intern Med. 1995 Apr 15;122(8):573-9. Unique Identifier : AIDSLINE MED/95193935; Mellors JW; Kingsley LA; Rinaldo CR Jr; Todd JA; Hoo BS; Kokka RP; Gupta P; University of Pittsburgh, Pennsylvania.; OBJECTIVE: To investigate the relation between the quantity of human immunodeficiency virus type 1 (HIV-1) RNA in plasma and the risk for the acquired immunodeficiency syndrome (AIDS) or a decline in the CD4+ T-cell count after seroconversion. DESIGN: Prospective study. PATIENTS: 62 homosexual men with documented HIV-
[Two cases of adult T-cell leukemia . lymphoma (ATL) with long-term remission by chronic daily administration of low-dose etoposide]: Gan To Kagaku Ryoho. 1995 Mar;22(4):547-52. Unique Identifier : AIDSLINE MED/95194038; Ezoe A; Kohda K; Hirayama Y; Nobuoka A; Matsumoto S; Nakazawa O; Takahashi H; Muramatsu H; Matsunaga T; Watanabe N; et al; Dept. of Internal Medicine, Asahikawa Red Cross Hospital.; We tried long-term oral administration of low-dose etoposide (LDE) for seven patients with adult T-cell leukemia . lymphoma (ATL) at Asahikawa Red Cross Hospital in 1988. Two long-term survivors are presented. Case 1: A 53-year-old man was diagnosed as acute ATL in 1987. Because VEPA therapy was not effective, LDE (50
Differentiation and clonality of lesional lymphocytes in small plaque parapsoriasis [see comments]: Arch Dermatol. 1995 Mar;131(3):321-4. Unique Identifier : AIDSLINE MED/95194053; Haeffner AC; Smoller BR; Zepter K; Wood GS; Department of Dermatology, Case Western Reserve University,; Cleveland, Ohio.; BACKGROUND: Small plaque parapsoriasis is an idiopathic chronic dermatosis characterized by patches on the trunk and extremities that are often smaller than 5 cm in diameter and that sometimes have a digitate contour. These latter cases are often referred to as digitate dermatosis. Histopathologic examination reveals
Cutaneous thrombosis in human immunodeficiency virus type 1-positive patients and cytomegalovirus viremia [letter]: Arch Dermatol. 1995 Mar;131(3):357-8. Unique Identifier : AIDSLINE MED/95194064; Smith KJ; Skelton HG; Yeager J; Wagner KF
Itraconazole therapy for human immunodeficiency virus-associated eosinophilic folliculitis [letter]: Arch Dermatol. 1995 Mar;131(3):358-60. Unique Identifier : AIDSLINE MED/95194065; Berger TG; Heon V; King C; Schulze K; Conant MA
Eosinophilic folliculitis associated with the acquired immunodeficiency syndrome responds well to permethrin [letter]: Arch Dermatol. 1995 Mar;131(3):360-1. Unique Identifier : AIDSLINE MED/95194066; Blauvelt A; Plott RT; Spooner K; Stearn B; Davey RT; Turner ML
Diabetes mellitus following intravenous pentamidine administration in a patient with HIV infection [letter]: Arch Intern Med. 1995 Mar 27;155(6):645-6. Unique Identifier : AIDSLINE MED/95194159; Nasti G; Zanette G; Inchiostro S; Donadon V; Tirelli U
A spectrum in the pathology of toxoplasmosis in patients with acquired immunodeficiency syndrome.: Arch Pathol Lab Med. 1995 Mar;119(3):214-24. Unique Identifier : AIDSLINE MED/95194168; Bertoli F; Espino M; Arosemena JR 5th; Fishback JL; Frenkel JK; Department of Pathology, Metropolitan Social Security Hospital; Complex, Panama City, Republic of Panama.; We describe a variety of toxoplasmic lesions in seven patients with the acquired immunodeficiency syndrome. The first patient had multiple small-intestinal ulcers associated with Toxoplasma tachyzoites and high antibody titers; he died of disseminated histoplasmosis. The second patient, who died of tuberculosis, also
3-Azido-3'-deoxythymidine and 2',3'-dideoxycytidine do not inhibit gene-specific DNA repair in hamster cells.: Biochem Biophys Res Commun. 1995 Mar 8;208(1):198-203. Unique Identifier : AIDSLINE MED/95194407; Link CJ Jr; Bohr VA; Laboratory of Molecular Pharmacology, National Cancer Institute,; Bethesda, MD 20892.; 3-Azido-3 -deoxythymidine ( AZT ) was the first approved drug for the treatment of the AIDS; however, despite its usefulness, AZT often produces side effects that require cessation of therapy. 2 ,3 -Dideoxycytidine (
Differential effects of a hydrophobic tripeptide on human immunodeficiency virus type 1 (HIV-1)-induced syncytium formation and viral infectivity.: Biochem Biophys Res Commun. 1995 Mar 8;208(1):75-81. Unique Identifier : AIDSLINE MED/95194450; Konopka K; Pretzer E; Duzgunes N; Department of Microbiology, University of the Pacific, School of; Dentistry, San Francisco, CA 94115.; The synthetic hydrophobic peptide, Z-D-Phe-L-Phe-Gly, was shown previously to inhibit the infectivity of paramyxoviruses and the fusion of Sendai virus with liposomes. We examined the ability of this peptide to inhibit HIV-1 infectivity in A3.01, Sup-T1, and H9 cells and syncytium formation between these cells and chr
Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells.: J Autoimmun. 1994 Dec;7(6):819-31. Unique Identifier : AIDSLINE MED/95194524; Whalen BJ; Greiner DL; Mordes JP; Rossini AA; Department of Medicine, University of Massachusetts Medical; School, Worcester 01655.; We describe the induction and prevention of autoimmune insulin dependent diabetes mellitus (IDDM), and its pathological substrate, insulitis, in congenitally athymic nude rats following injections of major histocompatibility complex (MHC) compatible lymph node T cells. The cells capable of adoptive transfer of autoimm
Plant-derived metabolites with synergistic antioxidant activity [letter; comment]: Immunol Today. 1995 Feb;16(2):108. Unique Identifier : AIDSLINE MED/95194552; Beukelman CJ; Van den Berg AJ; Kroes BH; Labadie RP; Mattsson EE; Van Dijk H
Human herpesvirus 6 in AIDS.: Immunol Today. 1995 Feb;16(2):67-71. Unique Identifier : AIDSLINE MED/95194561; Lusso P; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MA 20892.; Multiple lines of clinical and experimental evidence suggest that human herpesvirus 6 (HHV-6) may act as an accelerating factor in the natural history of human immunodeficiency virus (HIV) infection. Although, in common with HIV, HHV-6 has a primary tropism for CD4+ T cells, its potential effects on the immune system
CD30, Th2 cytokines and HIV infection: a complex and fascinating link.: Immunol Today. 1995 Feb;16(2):76-80. Unique Identifier : AIDSLINE MED/95194563; Del Prete G; Maggi E; Pizzolo G; Romagnani S; Division of Clinical Immunology and Allergy, University of; Florence, Italy.; CD30 is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily, and was originally described as a marker of Hodgkin s and Reed-Sternberg cells in Hodgkin s lymphoma. CD30 is preferentially expressed on CD4+ and CD8+ T-cell clones that produce T helper 2 (Th2)-type cytokines, and is
Recombinant leech-derived tryptase inhibitor: construction, production, protein chemical characterization and inhibition of HIV-1 replication.: Biol Chem Hoppe Seyler. 1994 Oct;375(10):695-703. Unique Identifier : AIDSLINE MED/95194576; Auerswald EA; Morenweiser R; Sommerhoff CP; Piechottka GP; Eckerskorn C; Gurtler LG; Fritz H; Abteilung fur Klinische Chemie und Klinische Biochemie, Klinikum; Innenstadt, Ludwig-Maximilians-Universitat Munchen, Germany.; A synthetic gene coding for leech-derived tryptase inhibitor, form C (LDTI-C), was designed, cloned and expressed. The gene assembled via 6 oligonucleotides contains linker sequences, stop codons and internal restriction recognition sites for cloning, expression and cassette mutagenesis. Periplasmatic expression produ
Diagnostic strategies in HIV-infected patients with diarrhea [editorial] [see comments]: AIDS. 1994 Dec;8(12):1639-48. Unique Identifier : AIDSLINE MED/95194608; Mayer HB; Wanke CA
Identification of an env G subtype and heterogeneity of HIV-1 strains in the Russian Federation and Belarus.: AIDS. 1994 Dec;8(12):1649-55. Unique Identifier : AIDSLINE GENBANK/U08368; Bobkov A; Cheingsong-Popov R; Garaev M; Rzhaninova A; Kaleebu P; Beddows S; Bachmann MH; Mullins JI; Louwagie J; Janssens W; et al; Department of Molecular Virology, D.I. Ivanovsky Institute of; Virology, Moscow, Russia.; OBJECTIVE: To identify HIV-1 envelope sequence subtypes in infected individuals from the Russian Federation and Belarus . PATIENTS: A cohort of children infected after exposure to non-sterile needles during the 1988-1989 HIV-1 epidemic in southern Russia (n = 20) and HIV-1-seroposi
Antibodies to V3 loop peptides derived from chimpanzee lentiviruses and the divergent HIV-1ANT-70 isolate in human sera from different geographic regions.: AIDS. 1994 Dec;8(12):1657-61. Unique Identifier : AIDSLINE MED/95194610; Peeters M; Nkengasong J; Willems B; Karita E; Delaporte E; Van den Haesevelde M; Piot P; van der Groen G; Institute of Tropical Medicine, Antwerp, Belgium.; OBJECTIVE: To study the spread of antibodies to V3 loop peptides of two chimpanzee lentiviruses and the divergent HIV-1ANT-70 isolate (group O) in human sera from different geographic regions, and to compare this with reactions to peptides from known North American (subtype B) and Zairean (subtype D) strains. METHODS:
Distinct alterations in the distribution of CD45RO+ T-cell subsets in HIV-2 compared with HIV-1 infection.: AIDS. 1994 Dec;8(12):1663-8. Unique Identifier : AIDSLINE MED/95194611; Jaleco AC; Covas MJ; Pinto LA; Victorino RM; Department of Medicine 2/Clinical Immunology, Faculty of Medicine; of Lisbon, Santa Maria Hospital, Portugal.; OBJECTIVE AND DESIGN: Some clinical studies indicate that disease progression in HIV-2-infected subjects may be slower than in HIV-1. We investigated whether there were differences in the distribution of CD45RO+ (memory) and CD45RA+ (naive) T-cell subsets between HIV-1 and HIV-2 infection. METHODS: Analysis of lymphoc
Detection of HIV-1 proviral DNA in sperm from HIV-1-infected men.: AIDS. 1994 Dec;8(12):1669-74. Unique Identifier : AIDSLINE MED/95194612; Bagasra O; Farzadegan H; Seshamma T; Oakes JW; Saah A; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107.; OBJECTIVE: Sexual transmission is a major mode of the spread of HIV-1, although the cellular and molecular mechanisms are poorly defined. In this study, we sought to assess the cellular reservoirs of HIV-1 proviral DNA in the semen of HIV-1-infected men. DESIGN AND METHODS: An in situ polymerase chain reaction (IS-PCR
The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors.: AIDS. 1994 Dec;8(12):1675-82. Unique Identifier : AIDSLINE GENBANK/M33197; Yamaguchi K; Groopman JE; Byrn RA; New England Deaconess Hospital, Department of Medicine, Harvard; Medical School, Boston, Massachusetts 02215.; OBJECTIVES: To analyze the effect of retinoic acids (RA) on HIV-1 expression and correlate this effect with expression levels of RA receptors (RARs) in T-lymphoid and monocytoid cell lines. DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid (H9, CEM) and monocytoid (U937,THP-1)
Pharmacokinetic variability of zidovudine in HIV-infected individuals: subgroup analysis and drug interactions.: AIDS. 1994 Dec;8(12):1683-9. Unique Identifier : AIDSLINE MED/95194614; Burger DM; Meenhorst PL; ten Napel CH; Mulder JW; Neef C; Koks CH; Bult A; Beijnen JH; Department of Pharmacy, Slotervaart Hospital, Amsterdam, The; Netherlands.; OBJECTIVE: To investigate determinants of inter- and intraindividual variability of zidovudine (ZDV) pharmacokinetics in HIV-infected patients. DESIGN: A prospective study in a general 525-bed hospital with special funding for treatment and research of HIV-infected patients. METHODS: Serial blood samples were collecte
Polymerase chain reaction for Toxoplasma gondii DNA in the cerebrospinal fluid of AIDS patients with focal brain lesions.: AIDS. 1994 Dec;8(12):1691-4. Unique Identifier : AIDSLINE MED/95194615; Novati R; Castagna A; Morsica G; Vago L; Tambussi G; Ghezzi S; Gervasoni C; Bisson C; d'Arminio Monforte A; Lazzarin A; Infectious Diseases Department, San Raffaele Scientific; Institute, Milan, Italy.; OBJECTIVE: To study the accuracy of polymerase chain reaction (PCR) for Toxoplasma gondii DNA in the cerebrospinal fluid (CSF) of AIDS patients for the diagnosis of T. gondii encephalitis. PATIENTS: Eighty-two AIDS patients with brain lesions. At autopsy, 19 patients (group A) had toxoplasmic encephalitis and 33 (grou
Risk factors for HIV infection among drug users in Yunnan province, China: association with intravenous drug use and protective effect of boiling reusable needles and syringes.: AIDS. 1994 Dec;8(12):1701-6. Unique Identifier : AIDSLINE MED/95194617; Xia M; Kreiss JK; Holmes KK; Institute of Epidemiology and Microbiology, Chinese Academy of; Preventive Medicine, Beijing.; OBJECTIVES: To characterize the prevalence and correlates of HIV infection among drug users in southwestern China . METHODS: Drug users in Longdao village, Yunnan Province underwent standardized interview and voluntary HIV serologic testing in a cross-sectional study. Analyses of pot
Demographic impact of HIV infection in rural Rakai district, Uganda: results of a population-based cohort study.: AIDS. 1994 Dec;8(12):1707-13. Unique Identifier : AIDSLINE MED/95194618; Sewankambo NK; Wawer MJ; Gray RH; Serwadda D; Li C; Stallings RY; Musgrave SD; Konde-Lule J; Department of Medicine, Makerere University, Kampala, Uganda.; OBJECTIVES: To examine HIV-1-related mortality and demographic impact in a high HIV prevalence rural district of Uganda . DESIGN: One-year follow-up (1990-1991) in a population-based rural cohort. SETTING AND PARTICIPANTS: Annual enumeration of all consenting residents of 1945 house
Sensitivity of HIV-antibody assays determined by seroconversion panels.: AIDS. 1994 Dec;8(12):1715-20. Unique Identifier : AIDSLINE MED/95194619; Constantine NT; van der Groen G; Belsey EM; Tamashiro H; Global Programme on AIDS, World Health Organization, Geneva,; Switzerland.; OBJECTIVES: To determine the sensitivity of HIV-antibody assays for detecting low levels of HIV antibody using seroconversion and other panels containing plasma of varying titres. METHODS: Eight HIV-antibody assays, available under the World Health Organization bulk-procurement agreeme
Death from suicide and overdose among drug injectors after disclosure of first HIV test result.: AIDS. 1994 Dec;8(12):1721-5. Unique Identifier : AIDSLINE MED/95194620; van Haastrecht HJ; Mientjes GH; van den Hoek AJ; Coutinho RA; Municipal Health Service, Department of Public Health and; Environment, Amsterdam, The Netherlands.; OBJECTIVE: To investigate whether notifying injecting drug users (IDU) of their positive HIV serostatus contributes to suicide and overdose mortality risk. DESIGN: Members of a cohort of IDU, recruited since December 1985, who first learned their HIV serostatus after study entry but before December 1992, were studied
CD26 is not involved in infection of peripheral blood mononuclear cells by HIV-1 [letter]: AIDS. 1994 Dec;8(12):1727-8. Unique Identifier : AIDSLINE MED/95194621; Stamatatos L; Levy JA
In vitro immunoglobulin synthesis as a CD4+ lymphocyte depletion predictor in HIV-1-infected asymptomatic haemophiliacs [letter]: AIDS. 1994 Dec;8(12):1728-9. Unique Identifier : AIDSLINE MED/95194622; Cavallin F; Traldi A; Di Gaetano R; Zambello R
Infectivity and virulence of cell-associated SIVmac after single passage in vivo [letter]: AIDS. 1994 Dec;8(12):1730-1. Unique Identifier : AIDSLINE MED/95194623; Niphuis H; Dubbes RH; ten Haaft PJ; Koornstra WH; Bontrop RE; Cranage MP; Heeney JL
HIV interaction with sperm [letter]: AIDS. 1994 Dec;8(12):1733-6. Unique Identifier : AIDSLINE MED/95194625; Scofield VL; Rao B; Broder S; Kennedy C; Wallace M; Graham B; Poiesz BJ
HIV-1 infection detected by polymerase chain reaction frequently precedes antibody seroconversion in drug users [letter]: AIDS. 1994 Dec;8(12):1736-7. Unique Identifier : AIDSLINE MED/95194626; Bruisten SM; Mientjes GH; van Delft P; de Wolf F; van Ameijden EJ; Cornelissen M; Goudsmit J; Coutinho RA; Huisman JG
Testing for HIV antibody in saliva and HIV-testing centres [letter]: AIDS. 1994 Dec;8(12):1738-9. Unique Identifier : AIDSLINE MED/95194627; Belec L; Lwin S; Pillot J
Stable prevalence of HIV-1 in African populations [letter]: AIDS. 1994 Dec;8(12):1739-40. Unique Identifier : AIDSLINE MED/95194628; Hudson CP
Prognostic value of triglyceride levels in early HIV infection [letter]: AIDS. 1994 Dec;8(12):1740-1. Unique Identifier : AIDSLINE MED/95194629; Gomez-Sirvent JL; Alonso-Socas MM; Santolaria-Fernandez FJ; Gonzalez-Reimers CE; Rodriguez-Moreno F; Essardas-Daryanani H
Cryptococcal meningitis in HIV-infected patients [letter]: AIDS. 1994 Dec;8(12):1741-3. Unique Identifier : AIDSLINE MED/95194630; Leenders AC; van der Ende ME; van der Ree TC; de Marie S
Statistics from the World Health Organization.: AIDS. 1994 Dec;8(12):1745-6. Unique Identifier : AIDSLINE MED/95194631
Tenth anniversary perspectives on AIDS. HIV: between past and future.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1317-24. Unique Identifier : AIDSLINE MED/95194689; Myers G; HIV Sequence Database and Analysis Project, Los Alamos National; Laboratory, New Mexico 87545.
The World Health Organization Network for HIV Isolation and Characterization: summary of a pilot study.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1325-6. Unique Identifier : AIDSLINE MED/95194690; Osmanov S; Heyward WL; Esparza J; Vaccine Development Unit, World Health Organization, Geneva,; Switzerland.
Rapid genetic characterization of HIV type 1 strains from four World Health Organization-sponsored vaccine evaluation sites using a heteroduplex mobility assay. WHO Network for HIV Isolation and Characterization.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1345-53. Unique Identifier : AIDSLINE MED/95194692; Bachmann MH; Delwart EL; Shpaer EG; Lingenfelter P; Singal R; Mullins JI; Department of Cancer Biology, Harvard School of Public Health,; Boston, Massachusetts 02115.; To assist in the preparation for the testing of vaccines against human immunodeficiency virus (HIV) we, as part of the World Health Organization Network for HIV Isolation and Characterization (WHO-NHIC), evaluated the genotypic variation of HIV-1 in cohorts from
The World Health Organization Global Programme on AIDS proposal for standardization of HIV sequence nomenclature. WHO Network for HIV Isolation and Characterization.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1355-8. Unique Identifier : AIDSLINE MED/95194693; Korber BT; Osmanov S; Esparza J; Myers G; Theory Division, Los Alamos National Laboratory, New Mexico; 87545.; The World Health Organization Global Programme on AIDS (WHO/GPA) is conducting a large-scale collaborative study of human immunodeficiency virus type 1 (HIV-1) variation, based in four potential vaccine-trial site countries: Brazil ,
Genetic variation of HIV type 1 in four World Health Organization-sponsored vaccine evaluation sites: generation of functional envelope (glycoprotein 160) clones representative of sequence subtypes A, B, C, and E. WHO Network for HIV Isolation and Characterization.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1359-68. Unique Identifier : AIDSLINE GENBANK/U09131; Gao F; Yue L; Craig S; Thornton CL; Robertson DL; McCutchan FE; Bradac JA; Sharp PM; Hahn BH; Department of Medicine, University of Alabama at Birmingham; 35294.; As part of the WHO Network for HIV Isolation and Characterization, we PCR amplified, cloned, and sequenced gp120 and gp160 genes from 12 HIV-1 isolates collected in four WHO-sponsored vaccine evaluation sites ( Brazil , Rwanda ,
Antigenic variation and serotyping of HIV type 1 from four World Health Organization-sponsored HIV vaccine sites. WHO Network for HIV Isolation and Characterization.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1369-77. Unique Identifier : AIDSLINE MED/95194695; Pau CP; Kai M; Holloman-Candal DL; Luo CC; Kalish ML; Schochetman G; Byers B; George JR; Division of HIV/AIDS, Centers for Disease Control and Prevention,; U.S. Department of Health and Human Services, Atlanta, Georgia; 30333.; Serologic reactivities of serum or plasma from 55 HIV-1 subjects in four countries-- Brazil , Rwanda , Thailand , and Uganda--were examined by V3 peptide immunoassay. Forty-seven (85.5%) of the 55 specimens tes
Serotyping HIV type 1 by antibody binding to the V3 loop: relationship to viral genotype. WHO Network for HIV Isolation and Characterization.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1379-86. Unique Identifier : AIDSLINE MED/95194696; Cheingsong-Popov R; Lister S; Callow D; Kaleebu P; Beddows S; Weber J; Department of Genito-Urinary Medicine and Communicable Diseases,; St. Mary's Hospital Medical School, London, U.K.; We have investigated whether peptides representing the HIV-1 principal neutralization domain (V3) can be used as antigens in antibody-binding assays to predict the genotypes of the subjects virus. Serum samples collected from HIV-1-infected subjects from the four WHO-sponsored vaccine evaluation sites (
Syncytium-inducing and non-syncytium-inducing capacity of human immunodeficiency virus type 1 subtypes other than B: phenotypic and genotypic characteristics. WHO Network for HIV Isolation and Characterization.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1387-400. Unique Identifier : AIDSLINE MED/95194697; De Wolf F; Hogervorst E; Goudsmit J; Fenyo EM; Rubsamen-Waigmann H; Holmes H; Galvao-Castro B; Karita E; Wasi C; Sempala SD; et al; Department of Virology, University of Amsterdam, The Netherlands.; Positively charged amino acid substitutions at positions 11 and 25 within the loop of the third variable region (V3) of HIV-1 subtype B envelope have been shown to be associated with the syncytium-inducing (SI) phenotype of the virus. The present study was designed to examine SI and NSI-associated V3 mutations in HIV-
Standard conditions of virus isolation reveal biological variability of HIV type 1 in different regions of the world. WHO Network for HIV Isolation and Characterization.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1401-8. Unique Identifier : AIDSLINE MED/95194698; Rubsamen-Waigmann H; von Briesen H; Holmes H; Bjorndal A; Korber B; Esser R; Ranjbar S; Tomlinson P; Galvao-Castro B; Karita E; et al; Georg-Speyer-Haus Chemotherapeutisches Forschunginstitut,; Frankfurt, Germany.; HIV-1 isolates were obtained from four countries within the framework of the WHO Network for HIV Isolation and Characterization. The use of standard HIV isolation procedures allowed us to compare the biological properties of 126 HIV-1 isolates spanning five genetic subtypes. In primary isolation cultures, viruses from
Comparative biology and pathogenesis of AIDS and hepatitis B viruses: related but different.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1409-19. Unique Identifier : AIDSLINE MED/95194699; Hilleman MR; Merck Institute for Therapeutic Research, Merck Research; Laboratories, West Point, Pennsylvania 19486.; AIDS (HIV) and hepatitis B viruses are remarkably similar in their sharing of reverse transcription, in their ancestral origins and common genetic elements, and in their modes of transmission. Both are hypermutable and exist as quasispecies due primarily to errors in reverse transcription, though there is severe restr
V3-mediated heparin neutralization of HIV type 1.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1421-3. Unique Identifier : AIDSLINE MED/95194700; Javaherian K; Khiroya R; Quinlan C; Boyd JG; Hanham KA; Repligen Corporation, Cambridge, Massachusetts 02139.
Reactivity of AIDS patient sera with a peptide derived from HIV type 1NY5 glycoprotein 120 V3 loop and consensus sequence of collagens.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1425-6. Unique Identifier : AIDSLINE MED/95194701; Metlas R; Skerl V; Pongor S; Colombatti A; Veljkovic V; Laboratory for Multidisciplinary Research 180/2, Institute for; Nuclear Sciences Vinca, Beograd, Yugoslavia.
A novel method for detection and ex vivo expansion of HIV type 1-specific cytolytic T lymphocytes.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1427-31. Unique Identifier : AIDSLINE MED/95194702; Lubaki MN; Egan MA; Siliciano RF; Weinhold KJ; Bollinger RC; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205.; Studies have shown that cytolytic T lymphocyte (CTL) responses may be critical to the clearance of the early viremia in acute HIV-1 infection. It is likely that these cells play an important role in prolonging the asymptomatic phase of the infection. Although HIV-1-specific CTL activity can be detected in direct assay
A qualitative progression in HIV type 1 glycoprotein 120-specific cytotoxic cellular and humoral immune responses in mice receiving a DNA-based glycoprotein 120 vaccine.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1433-41. Unique Identifier : AIDSLINE MED/95194703; Fuller DH; Haynes JR; Agracetus, Inc., Middleton, Wisconsin 53562.; The potential for eliciting humoral and cytotoxic T lymphocyte (CTL) responses to HIV-1 gp120 by gene gun-based DNA immunization in mice was examined. We speculated that the induction of de novo antigen production in the epidermis of BALB/c mice following particle bombardment-based gene delivery would result in both M
Immunogenicity of recombinant adenovirus-human immunodeficiency virus vaccines in chimpanzees following intranasal administration [published erratum appears in AIDS Res Hum Retroviruses 1995 Jan;11(1):189]: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1443-9. Unique Identifier : AIDSLINE MED/95194704; Lubeck MD; Natuk RJ; Chengalvala M; Chanda PK; Murthy KK; Murthy S; Mizutani S; Lee SG; Wade MS; Bhat BM; et al; Department of Biotechnology and Microbiology, Wyeth-Ayerst; Research, Radner, Pennsylvania 19087.; Recombinant adenovirus (Ad)-human immunodeficiency virus (HIV) vaccines expressing HIVIIIB Env and Gag proteins were evaluated for immunogenicity in chimpanzees following intranasal administration. When Ad7-, Ad4-, and Ad5-vectored vaccines were administered sequentially at 0, 24, and 52 weeks, respectively, to three
Stimulation of glutathione peroxidase activity decreases HIV type 1 activation after oxidative stress.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1451-61. Unique Identifier : AIDSLINE MED/95194705; Sappey C; Legrand-Poels S; Best-Belpomme M; Favier A; Rentier B; Piette J; Laboratory of Virology, University of Liege, Belgium.; Am important aspect of human immunodeficiency virus (HIV-1) infection is the regulation of its expression by nuclear factor kappa B (NF-kappa B) by redox-controlled signal transduction pathways. In this study, we demonstrate that selenium supplementation can effectively increase glutathione peroxidase (GPx) activity i
Comparison of cellular accumulation, tissue distribution, and anti-HIV activity of free and liposomal 2',3'-dideoxycytidine.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1463-70. Unique Identifier : AIDSLINE MED/95194706; Makabi-Panzu B; Lessard C; Perron S; Desormeaux A; Tremblay M; Poulin L; Beauchamp D; Bergeron MG; Laboratoire et Service d'Infectiologie, Centre de Recherche du; Centre Hospitalier de l'Universite Laval, Ste-Foy, Quebec,; Canada.; We have investigated the cellular accumulation, tissue distribution, and antihuman immunodeficiency virus activity of free dideoxycytidine ( ddC ) and liposomal ddC (L-ddC). We have found that L-ddC was more efficiently taken up than its free form by RA
Zidovudine induces the expression of cellular resistance affecting its antiviral activity.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1471-8. Unique Identifier : AIDSLINE MED/95194707; Dianzani F; Antonelli G; Turriziani O; Riva E; Simeoni E; Signoretti C; Strosselli S; Cianfriglia M; Institute of Virology, University La Sapienza, Rome, Italy.; We have previously shown that multidrug-resistant cells expressing the multidrug transporter P-glycoprotein are less sensitive to the antiviral activity of AZT . Subsequently, we addressed the question whether AZT itself is able to induce cellular resi
Calmodulin antagonists inhibit human immunodeficiency virus-induced cell fusion but not virus replication.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1489-96. Unique Identifier : AIDSLINE MED/95194709; Srinivas RV; Bernstein H; Oliver C; Compans RW; Department of Infectious Diseases, St. Jude Children's Research; Hospital, Memphis, Tennessee 38105.; We have reported that amphipathic helical segments in the cytoplasmic domain of the HIV-1 envelope glycoproteins bind to calmodulin (CaM) with high affinity, and inhibit calmodulin-regulated proteins. To investigate the possible role of calmodulin activity in HIV-1 replication, we investigated the anti-HIV activity of
Potent and specific inhibition of HIV envelope-mediated cell fusion and virus binding by G quartet-forming oligonucleotide (ISIS 5320).: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1497-506. Unique Identifier : AIDSLINE MED/95194710; Buckheit RW Jr; Roberson JL; Lackman-Smith C; Wyatt JR; Vickers TA; Ecker DJ; Southern Research Institute-Frederick Research Center, Maryland; 21701.; We have previously reported identification of a phosphorothioate oligonucleotide TTGGGGTT (ISIS 5320) as a potent inhibitor of HIV infection in vitro. The oligonucleotide forms a parallel-stranded, tetrameric guanosine quartet (G-quartet) structure that specifically binds to the HIV envelope glycoprotein (gp120) and i
Further evaluation of soluble CD4 as an anti-HIV type 1 gene therapy: demonstration of protection of primary human peripheral blood lymphocytes from infection by HIV type 1.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1507-15. Unique Identifier : AIDSLINE MED/95194711; Morgan RA; Baler-Bitterlich G; Ragheb JA; Wong-Staal F; Gallo RC; Anderson WF; National Heart, Lung, and Blood Institute, National Institutes of; Health, Bethesda, Maryland 20892.; We previously reported on the construction of retroviral vectors that produce a secreted form of the HIV-1 receptor, T cell antigen CD4 (Morgan et al., AIDS Res Hum Retroviruses 1990;6:183-191). In this article we test the ability of these sCD4-expressing retroviral vectors to protect human T-cell lines or primary T c
Retrovirus-mediated transfer and long-term expression of HIV type 1 tat gene in murine hematopoietic tissues.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1517-9. Unique Identifier : AIDSLINE MED/95194712; Frazier AL; Garcia JV; Department of Virology and Molecular Biology, St. Jude Children's; Research Hospital, Memphis, Tennessee 38105.; Replication of the human immunodeficiency virus (HIV) is regulated tightly by the tat and rev genes. The tat gene of HIV is a potent trans-activator of virus gene expression. trans-Activation is mediated through the tat-responsive element (TAR). Tat also has been shown to affect transcription of cellular genes and to
Modulation of cellular gene expression of HIV type 1 infection as determined by subtractive hybridization cloning: downregulation of thymosin beta 4 in vitro and in vivo.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1525-9. Unique Identifier : AIDSLINE MED/95194713; Shahabuddin M; McKinley G; Potash MJ; Volsky DJ; Molecular Virology Laboratory, St. Luke's/Roosevelt Hospital; Center, New York, New York.; Chronic infection with HIV-1 has profound effects on host cell growth and function. We used subtractive hybridization cloning to identify genes whose expression is modulated by HIV-1 infection in the T leukemia cell line CEM. The gene encoding thymosin beta 4, a ubiquitous polypeptide associated with hematopoietic dif
Splicing variability in HIV type 1 revealed by quantitative RNA polymerase chain reaction.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1531-42. Unique Identifier : AIDSLINE MED/95194714; Neumann M; Harrison J; Saltarelli M; Hadziyannis E; Erfle V; Felber BK; Pavlakis GN; Human Retrovirus Section, National Cancer Institute-Frederick; Cancer Research and Development Center, Maryland 21702-1201.; A quantitative RNA-polymerase chain reaction (PCR) method able to detect the majority of mRNAs produced by human immunodeficiency virus type 1 (HIV-1) was developed and used to study expression of different HIV-1 clones in human cells. Amplified mRNAs were compared to known cDNA standards. This comparison permitted th
Presence of multiple genetic subtypes of human immunodeficiency virus type 1 proviruses in Uganda.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1543-50. Unique Identifier : AIDSLINE MED/95194715; Bruce C; Clegg C; Featherstone A; Smith J; Biryahawaho B; Downing R; Oram J; Centre for Applied Microbiology and Research, Porton Down,; Salisbury, UK.; DNA sequences encoding the C2-V3 regions or the C2-V5 regions of the surface glycoprotein gp120 of the human immunodeficiency virus type 1 (HIV-1) were amplified by the polymerase chain reaction (PCR) from peripheral blood mononuclear cells obtained in 1990/1992 from 20 infected Ugandans. The PCR-amplified DNA was clo
Molecular epidemiology of HTLV type I in Japan: evidence for two distinct ancestral lineages with a particular geographical distribution.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1557-66. Unique Identifier : AIDSLINE MED/95194717; Vidal AU; Gessain A; Yoshida M; Mahieux R; Nishioka K; Tekaia F; Rosen L; De The G; Unite d'Epidemiologie des Virus Oncogenes, Institut Pasteur,; Paris, France.; Japan is one of the highest endemic areas of the world for human T cell leukemia-lymphoma virus type I (HTLV-I). To gain new insight as to the origin of this virus in Japan and especially in the southern islands of the archipelago, we investigated the long terminal repeat (LTR) of 6
HTLV type I and HTLV type II infection among Indians and natives from Argentina.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1567-71. Unique Identifier : AIDSLINE MED/95194718; Bouzas MB; Zapiola I; Quiruelas S; Gorvein D; Panzita A; Rey J; Carnese FP; Corral R; Perez C; Zala C; et al; Grupo de Trabajo de SIDA Pediatrico, Hospital de Ninos Ricardo; Gutierrez, Buenos Aires, Argentina.; Endemic foci for HTLV-II infection have been identified in several Amerindian populations. To determine HTLV-I and/or HTLV-II infection among Amerindians living in Argentina we studied 454 sera or plasmas from Indians and natives from different areas of our country. All samples
Early HIV type 1 strains in Thailand were not responsible for the current epidemic.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1573-5. Unique Identifier : AIDSLINE GENBANK/U15588; Kalish ML; Luo CC; Weniger BG; Limpakarnjanarat K; Young N; Ou CY; Schochetman G; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333.
Genetic variability of HIV type 1 in Kenya.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1577-9. Unique Identifier : AIDSLINE GENBANK/U13006; Janssens W; Heyndrickx L; Fransen K; Temmerman M; Leonaers A; Ivens T; Motte J; Piot P; Van der Groen G; Department of Infection and Immunity, Institute of Tropical; Medicine, Antwerp, Belgium.
Subgroup G HIV type 1 isolates from Nigeria.: AIDS Res Hum Retroviruses. 1994 Nov;10(11):1581-3. Unique Identifier : AIDSLINE GENBANK/U13213; Abimiku AG; Stern TL; Zwandor A; Markham PD; Calef C; Kyari S; Saxinger WC; Gallo RC; Robert-Guroff M; Reitz MS; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.
AIDS research: the second decade.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1585-9. Unique Identifier : AIDSLINE MED/95194722; Laurence J; Laboratory for AIDS Virus Research, Cornell University Medical; College, New York, New York 10021.
Infection of dendritic cells with HIV type 1 [comment]: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1591-2. Unique Identifier : AIDSLINE MED/95194723; Knight SC; Antigen Presentation Research Group, St. Mary's Hospital Medical; School at Northwick Park Hospital, Harrow, U.K.
HIV type 1 infection of human cortical neuronal cells: enhancement by select neuronal growth factors.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1593-6. Unique Identifier : AIDSLINE MED/95194724; Mizrachi Y; Rodriguez I; Sweetnam PM; Rubinstein A; Volsky DJ; Albert Einstein College of Medicine, Bronx, New York 10461.; Neuronal cells in culture respond to neuronal growth factors by secondary cellular pathways similar to those described for activation of lymphocytes and macrophages. In HIV-1-infected T lymphocytes and in macrophages, these pathways were shown to converge on nuclear factors that bind and stimulate the HIV-1 LTR and le
Neural cell targets of human immunodeficiency virus type 1 in human fetal organotypic cultures.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1597-607. Unique Identifier : AIDSLINE MED/95194725; Hatch WC; Pousada E; Losev L; Rashbaum WK; Lyman WD; Department of Pathology, Albert Einstein College of Medicine,; Bronx, New York 10461.; Some children infected by HIV-1 demonstrate nervous system disease. Because a significant percentage of these children are believed to be infected during gestation and it is thought that HIV-1 may infect distinct glial populations, this work tested the hypothesis that different HIV-1 isolates can infect cells of the d
Heterokaryons formed between a rat myeloma and a mouse fibroblast are permissive for entry of HIV type 1.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1609-11. Unique Identifier : AIDSLINE MED/95194726; Simon JH; James W; Sir William Dunn School of Pathology, University of Oxford,; England.; Expression of CD4 is not sufficient for cellular susceptibility to HIV-1 entry. The majority of nonprimate cells appear to lack a factor that plays an accessory role to CD4 during virus-cell fusion. We have previously reported CD4-dependent entry in rat myeloma Y3 cells, and here we show that Y3 and CD4-expressing mou
Non-syncytium-inducing HIV type 1 isolated from infected individuals replicates in MT-2 cells.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1613-8. Unique Identifier : AIDSLINE MED/95194727; Forte SE; Byron KS; Sullivan JL; Somasundaran M; Department of Pediatrics, University of Massachusetts Medical; School, Worcester 01605.; Human immunodeficiency virus type 1 (HIV-1) isolates from six infected individuals less then 4 years of age were phenotyped for their syncytium-inducing (SI) ability in MT-2 cells. Three viral isolates that induced syncytia were detected. One SI isolate was from an individual who was in disease stage P2A,B,C and two S
Dysregulation of interleukin 8, interleukin 10, and interleukin 12 release by alveolar macrophages from HIV type 1-infected subjects.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1619-27. Unique Identifier : AIDSLINE MED/95194728; Denis M; Ghadirian E; Pulmonary Research Unit, University of Sherbrooke, Quebec,; Canada.; We examined the in vitro release of interleukin 8 (IL-8), interleukin 10 (IL-10), and interleukin 12 (IL-12) by alveolar macrophages from normal volunteers and HIV-1-infected subjects. Normal volunteers had very low levels of IL-8 and IL-10 and undetectable IL-12 in the cell-free bronchoalveolar lavage fluid (BALF). A
Analysis of B cell repertoire specific to the neutralizing epitopes of glycoprotein 120 in HIV-infected individuals.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1629-37. Unique Identifier : AIDSLINE MED/95194729; Hariharan K; Nara PL; Shabazz LA; McCutchan JA; Kang CY; IDEC Pharmaceuticals Corporation, San Diego, California 92121.; This study describes the clonotypic analysis of neutralizing anti-gp120 antibodies elicited in HIV-infected individuals by a panel of anti-idiotype monoclonal antibodies (anti-Id MAbs). Sera from 80 HIV-infected individuals at various clinical stages of HIV-infection were tested for reactivity to 19 anti-Id MAbs in EL
Molecular characterization of variable heavy and light chain regions of five HIV type 1-specific human monoclonal antibodies.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1639-49. Unique Identifier : AIDSLINE GENBANK/Z19546; van der Donk EM; Schutten M; Osterhaus AD; van der Heijden RW; Department of Virology, Erasmus University, Rotterdam, The; Netherlands.; We have reported the generation and characterization of four HIV-1 neutralizing human monoclonal antibodies. Three antibodies recognize a conformational epitope within the CD4-binding site of HIV-1 gp120 and one recognizes a linear epitope located within the hypervariable V3 domain of gp120. In the present study we re
A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1651-8. Unique Identifier : AIDSLINE MED/95194731; Purtscher M; Trkola A; Gruber G; Buchacher A; Predl R; Steindl F; Tauer C; Berger R; Barrett N; Jungbauer A; et al; Institute of Applied Microbiology, University of Agriculture,; Vienna, Austria.; We have established a hybridoma clone, designated 2F5, secreting a neutralizing human monoclonal antibody (MAb) specific for gp41 of human immunodeficiency virus type 1 (HIV-1). The epitope of MAb 2F5 was mapped to amino acid sequence Glu-Leu-Asp-Lys-Trp-Ala on the ectodomain of gp41. In this study different in vitro
Characterization of monoclonal antibodies to human immunodeficiency virus type 2 envelope glycoproteins.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1659-67. Unique Identifier : AIDSLINE MED/95194732; Traincard F; Rey-Cuille MA; Huon I; Dartevelle S; Mazie JC; Benichou S; Hybridolab, Institut Pasteur, Paris, France.; Twelve murine monoclonal antibodies (MAbs) to human immunodeficiency virus type 2 (isolate ROD) envelope glycoproteins have been generated and characterized. Nine MAbs were specific to the external gp125 and three reacted with the transmembrane gp36. A large majority of MAbs displayed a significant affinity for the na
Parallel evolution in the V3 region of HIV type 1 after infection of hemophiliacs from a homogeneous source.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1669-78. Unique Identifier : AIDSLINE GENBANK/S76446; Kasper P; Kaiser R; Oldenburg J; Brackmann HH; Matz B; Schneweis KE; Institut fur Medizinische Mikrobiologie und Immunologie,; Universitat Bonn, Germany.; To determine the genetic diversification in the highly functional V3 loop, we followed up five hemophiliacs who were infected by a homogeneous HIV-1 population from a contaminated clotting factor lot. Initially, all patients displayed identical DNA sequences in this part of the proviral env gene. Therefore, this uniqu
Conserved V3 loop sequences and transmission of human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1679-84. Unique Identifier : AIDSLINE GENBANK/U23680; Shpaer EG; Delwart EL; Kuiken CL; Goudsmit J; Bachmann MH; Mullins JI; Department of Microbiology and Immunology, Stanford University; School of Medicine, California 94305-5402.; The third variable region (V3) of the surface glycoprotein (gp120) of envelope sequence subtype B, type 1 human immunodeficiency virus (HIV-1B), is highly variable among T cell line-adapted viruses and syncytium-inducing HIV-1-B isolates. Here we analyze the V3 region sequences from 93 individuals close to the time of
HIV type 1-specific cytotoxic T lymphocytes stimulate HLA class I and intercellular adhesion molecule type 1 expression and increase beta 2-microglobulin levels in vitro.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1685-93. Unique Identifier : AIDSLINE MED/95194735; Jassoy C; Heinkelein M; Klinker H; Walker BD; Institute for Virology and Immunobiology, University of; Wurzburg, Germany.; Besides acting in a direct manner, cytolytic HIV-1-specific CTLs release a variety of cytokines. To assess the potential role of cytokines released by these CTLs we tested the ability of soluble products secreted by HIV-1-specific CTLs to induce HLA class I and ICAM-1 expression and to raise beta 2-microglobulin (beta
Ultraviolet-light-inactivated Cas-Br-M murine leukemia virus induces a protective CD8+ cytotoxic T lymphocyte response in newborn mice.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1695-702. Unique Identifier : AIDSLINE MED/95194736; Sarzotti M; Dean TA; Remington M; Hoffman PM; Retrovirus Research Center, Veterans Affairs Medical Center,; Baltimore, Maryland 21201.; Newborn NFS/N mice are susceptible to the neurological disease induced by infection with Cas-Br-M murine leukemia virus (Cas), and do not develop a protective cytotoxic T cell (CTL)-mediated response to Cas infection. Here we demonstrate that whole UV light-inactivated Cas (UV-Cas), inoculated in newborn NFS/N mice, i
Absence of recoverable infectious virus and unique immune responses in an asymptomatic HIV+ long-term survivor.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1703-11. Unique Identifier : AIDSLINE MED/95194737; Schwartz D; Sharma U; Busch M; Weinhold K; Matthews T; Lieberman J; Birx D; Farzedagen H; Margolick J; Quinn T; et al; Department of Molecular Microbiology and Immunology, Johns; Hopkins University School of Hygiene and Public Health,; Baltimore, Maryland 21205.; We have studied a woman with transfusion-acquired HIV who appears to have contained infectious virus to consistently undetectable levels over a 13-year period without antiviral treatment. She received the infected transfusion for intra- and postpartum blood loss immediately after delivery of her second child in 1981.
Studies of high doses of a human immunodeficiency virus type 1 recombinant glycoprotein 160 candidate vaccine in HIV type 1-seronegative humans. The AIDS Vaccine Clinical Trials Network.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1713-23. Unique Identifier : AIDSLINE MED/95194738; Keefer MC; Graham BS; Belshe RB; Schwartz D; Corey L; Bolognesi DP; Stablein DM; Montefiori DC; McElrath MJ; Clements ML; et al; Department of Medicine, University of Rochester School of; Medicine and Dentistry, New York 14642.; We examined the safety and immunogenicity of a baculovirus-derived recombinant HIV-1 envelope glycoprotein vaccine candidate, rgp160 (VaxSyn; MicroGeneSys, Meriden, CT), administered at doses of 160 or 640 micrograms to 56 healthy, HIV-1-seronegative adults, in a randomized, double-blind, placebo-controlled study. Imm
Comparison of the sensitivities of primary isolates of HIV type 2 and HIV type 1 to antiviral drugs and drug combinations.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1725-9. Unique Identifier : AIDSLINE MED/95194739; Cox SW; Aperia K; Albert J; Wahren B; Virology Department, Swedish Institute for Infectious Disease; Control, Karolinska Institute, Stockholm.; The sensitivity of primary isolates of HIV-2 to the antiretroviral drugs 3 -azido-3 -deoxythymidine ( AZT ), 2 ,3 -dideoxyinosine (ddI), and 3 -fluoro-3 -deoxythymidine (FLT) was measured in vitro in PBMCs and compared to that of primary isolates of HIV
Early stages of feline immunodeficiency virus infection in lymph nodes and spleen.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1731-8. Unique Identifier : AIDSLINE MED/95194740; Bach JM; Hurtrel M; Chakrabarti L; Ganiere JP; Montagnier L; Hurtrel B; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.; Analysis of the early stages of infection within the lymphoid organs is crucial for the understanding of the physiopathology of HIV infection. Such analysis can only be performed using animal models. Cats were infected with two strains of FIV and killed at regular intervals for a classic pathologic study along with a
Superinfection of cats with feline immunodeficiency virus subtypes A and B.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1739-46. Unique Identifier : AIDSLINE MED/95194741; Okada S; Pu R; Young E; Stoffs WV; Yamamoto JK; Department of Comparative and Experimental Pathology, College of; Veterinary Medicine, University of Florida, Gainesville 32610.; The ability of feline immunodeficiency virus (FIV) isolates from subtypes A and B to superinfect cats and cell cultures was tested. Three specific pathogen-free (SPF) cats were first inoculated with 10 ID50 of subtype B virus (FIVBang) and 30 weeks later inoculated with 100 ID50 of subtype A virus (FIVPet). On the bas
Presence of human T lymphotropic virus types I and II in Ghana, west Africa.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1747-50. Unique Identifier : AIDSLINE MED/95194742; Lal RB; Owen SM; Mingle J; Levine PH; Manns A; Retrovirus Diseases Branch, National Center for Infectious; Disease, CDC, Atlanta, Georgia 30333.; Until recently, HTLV-I was considered to be an Old World virus and HTLV-II was thought to be endemic in the Americas. However, the presence of HTLV-II among Pygmies and other populations of Africa has raised doubts as to whether HTLV-II is primarily a New World virus. The large serosurveys conducted in the urban and r
The long terminal repeat of the human immunodeficiency virus type 1 GER isolate shows a duplication of the TAR region.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1751-2. Unique Identifier : AIDSLINE GENBANK/S76651; Emiliani S; Delsert C; David C; Devaux C; Centre de Tri des Molecules anti-HIV, CNRS UPR9008 et INSERM; U249, Montpellier, France.
vpu and env sequence variability of HIV-1 isolates from Tanzania.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1753-4. Unique Identifier : AIDSLINE GENBANK/U12415; Siwka W; Schwinn A; Baczko K; Pardowitz I; Mhalu F; Shao J; Rethwilm A; ter Meulen V; Institut fur Virologie und Immunbiologie, Universitat; Wurzburg, Germany.
Sequence analysis of the glycoprotein 120 coding region of a new HIV type 1 subtype A strain (HIV-1IbNg) from Nigeria.: AIDS Res Hum Retroviruses. 1994 Dec;10(12):1755-7. Unique Identifier : AIDSLINE MED/95194745; Howard TM; Olaylele DO; Rasheed S; Laboratory of Viral Oncology and AIDS Research, University of; Southern California, School of Medicine, Los Angeles 90032-3626.
N-acetylation genotype and risk of severe reactions to sulphonamides in AIDS patients [letter]: Br J Clin Pharmacol. 1994 Dec;38(6):581-2. Unique Identifier : AIDSLINE MED/95194808; Delomenie C; Grant DM; Mathelier-Fusade P; Jacomet C; Leynadier F; Jacqz-Aigrain E; Rozenbaum W; Krishnamoorthy R; Dupret JM
AIDS focus. Communicating with parents.: Nurs Stand. 1995 Jan 11-17;9(16):50-3. Unique Identifier : AIDSLINE MED/95194837; Jensen H
AIDS focus. Altered body image.: Nurs Stand. 1995 Jan 11-17;9(16):54-6. Unique Identifier : AIDSLINE MED/95194838; Wintle H
Clinic for gay men opens at Guy's [interview by Kate Williams]: Nurs Stand. 1995 Jan 25-31;9(18):14-5. Unique Identifier : AIDSLINE MED/95194854; King S
Estimation of the prevalence of cryptococcal infection among patients infected with the human immunodeficiency virus in New York City.: Clin Infect Dis. 1994 Dec;19(6):1029-33. Unique Identifier : AIDSLINE MED/95195064; Currie BP; Casadevall A; Department of Medicine, Albert Einstein College of Medicine,; Bronx, New York.; Cryptococcal infections are not reportable illnesses, and there have been limited attempts to estimate their incidence or prevalence. This study estimates the prevalence of cryptococcal disease in New York City in 1991 among human immunodeficiency virus (HIV)-infected patients who were at risk. Numerator data were gen
Biological false-positive syphilis test results for women infected with human immunodeficiency virus.: Clin Infect Dis. 1994 Dec;19(6):1040-4. Unique Identifier : AIDSLINE MED/95195066; Augenbraun MH; DeHovitz JA; Feldman J; Clarke L; Landesman S; Minkoff HM; Department of Medicine, State University of New York Health; Science Center at Brooklyn 11203.; Regardless of the nontreponemal test used for the screening and diagnosis of syphilis, biological false-positive results (BFPs) are documented in 1%-2% of all cases. An association between BFPs and human immunodeficiency virus (HIV) infection in men has been suggested. We conducted a cohort study to determine whether
Adenovirus parotitis in patients with AIDS.: Clin Infect Dis. 1994 Dec;19(6):1045-8. Unique Identifier : AIDSLINE MED/95195067; Gelfand MS; Cleveland KO; Lancaster D; Corbett CE; Florendo NT; Department of Medical Education, Methodist Hospitals of Memphis,; Tennessee.; Adenoviruses are well documented as opportunistic pathogens in patients with immunocompromising conditions, including human immunodeficiency virus (HIV) infection. We recently diagnosed adenovirus infection of the parotid gland in two patients with AIDS. Viral cultures and electron microscopic examinations of parotid
Expanded distribution of an investigational drug in parallel with ongoing controlled clinical trials: the didanosine model.: Clin Infect Dis. 1994 Dec;19(6):1071-5. Unique Identifier : AIDSLINE MED/95195072; Pike IM; Daniels M; Wirtz CJ; Stout JJ; Quigley JJ; Bristol-Myers Squibb Company, Plainsboro, New Jersey.; The purpose of the didanosine Expanded Access Program was to provide a needed antiretroviral agent to individuals who were unable to tolerate other therapy for human immunodeficiency virus infection or in whom such therapy was failing. The logistics of establishing this program are described, and the results of on-sit
Rates and risk factors for adverse events associated with didanosine in the expanded access program.: Clin Infect Dis. 1994 Dec;19(6):1076-83. Unique Identifier : AIDSLINE MED/95195073; Schindzielorz A; Pike I; Daniels M; Pacelli L; Smaldone L; Bristol-Myers Squibb Pharmaceutical Research Institute,; Wallingford, Connecticut 06492.; The didanosine Expanded Access Program was the largest AIDS treatment program to prospectively evaluate the safety of an antiretroviral agent among patients with advanced human immunodeficiency virus (HIV) disease in whom therapy with zidovudine was failing. A total of 21,198 patients who had infections refractory to
Tuberculin reactions among attendees at a methadone clinic: relation to infection with the human immunodeficiency virus.: Clin Infect Dis. 1994 Dec;19(6):1100-4. Unique Identifier : AIDSLINE MED/95195076; MacGregor RR; Dunbar D; Graziani AL; Department of Medicine, University of Pennsylvania School of; Medicine, Philadelphia.; We tested 403 clients at an inner-city methadone clinic to determine the rate of positive tuberculin test reactions and to determine how this rate was influenced by race, gender, and infection with the human immunodeficiency virus (HIV). In addition to skin testing, an experimental urine test for antibody to HIV was o
Recurrent infection due to Legionella pneumophila in a patient with AIDS.: Clin Infect Dis. 1994 Dec;19(6):1130-2. Unique Identifier : AIDSLINE MED/95195080; Morley JN; Smith LC; Baltch AL; Smith RP; Department of Medicine, Stratton Veterans Affairs Medical Center,; Albany, New York.; We report a patient with AIDS who presented with community-acquired cavitary Legionella pneumophila pneumonia. The patient recovered after an extended course of treatment with macrolide antibiotics. He returned to the hospital 4 months later with a febrile illness. Chest radiograms appeared normal. Cultures of blood y
Cerebral mucormycosis associated with intravenous drug use: three case reports and review [see comments]: Clin Infect Dis. 1994 Dec;19(6):1133-7. Unique Identifier : AIDSLINE MED/95195081; Hopkins RJ; Rothman M; Fiore A; Goldblum SE; Department of Medicine, University of Maryland School of; Medicine, Baltimore.; We describe three cases of cerebral mucormycosis in intravenous drug users and review 22 previously reported cases. Involvement of the basal ganglia was demonstrated in all but two cases. Seven of the 10 patients tested for antibodies to the human immunodeficiency virus (HIV) were seronegative. Eight of the 25 patient
Mycobacterium genavense infection presenting as a solitary brain mass in a patient with AIDS: case report and review.: Clin Infect Dis. 1994 Dec;19(6):1152-4. Unique Identifier : AIDSLINE MED/95195087; Berman SM; Kim RC; Haghighat D; Mulligan ME; Fierer J; Wyle FC; Department of Medicine, Veterans Affairs Medical Center, Long; Beach, California.; Patients with AIDS are prone to developing infections with opportunistic pathogens. Recently, a new mycobacterium, Mycobacterium genavense, has been found to cause infection in patients with AIDS. Previously published reports indicate that patients who are infected with this organism present with the same clinical fea
Diagnosis of legionella sepsis by examination of a peripheral blood smear [letter]: Clin Infect Dis. 1994 Dec;19(6):1164-5. Unique Identifier : AIDSLINE MED/95195094; Babe KS Jr; Reinhardt JF
Varicella immunity in women infected with the human immunodeficiency virus [letter]: Clin Infect Dis. 1994 Dec;19(6):1165-6. Unique Identifier : AIDSLINE MED/95195095; Clark R; Wilson S; Williams T
Myelitis due to Toxoplasma gondii in a patient with AIDS [letter]: Clin Infect Dis. 1994 Dec;19(6):1167-8. Unique Identifier : AIDSLINE MED/95195097; Lortholary O; Lisovoski F; Brechot JM; Longuet P; Perronne C; Leport C; Vilde JL
Staphylococcus xylosus isolated from a pancreatic pseudocyst in a patient infected with the human immunodeficiency virus [letter; comment]: Clin Infect Dis. 1994 Dec;19(6):1173-4. Unique Identifier : AIDSLINE MED/95195103; Mastroianni A; Coronado O; Nanetti A; Chiodo F
Bronchoalveolar carcinoma, lymphoid interstitial pneumonia, and retroviruses [letter]: Clin Infect Dis. 1994 Dec;19(6):1178-9. Unique Identifier : AIDSLINE MED/95195107; Peterschmitt AM; Moro DG; Perron HJ; Brambilla EM
[Dynamics of expression of the complex of activation markers in human peripheral blood CD4+, CD8+ lymphocytes during polyclonal stimulation in vitro]: Biull Eksp Biol Med. 1994 Nov;118(11):483-5. Unique Identifier : AIDSLINE MED/95195184; Koval'chuk LV; Beda MV; Veselova AV; Dement'eva EG; Mishin VIu; Chervinskaia TA; Il'ina NI
Lack of correlation between human T-lymphotropic virus type I DNA integration and clinical course of adult T-cell leukemia/lymphoma [letter; comment]: Blood. 1995 Mar 15;85(6):1673-5. Unique Identifier : AIDSLINE MED/95195239; D'Incan M; Souteyrand P; Antoniotti O; Gasmi M; Desgranges C; Fonck Y; Chassagne J
[The need for long-term continuation of AIDS prevention (news)]: Gesundheitswesen. 1995 Jan;57(1):44. Unique Identifier : AIDSLINE MED/95195305
Russia proposes testing foreigners for AIDS [news]: BMJ. 1994 Nov 12;309(6964):1253-4. Unique Identifier : AIDSLINE MED/95195433; Conradi P
Danish court clears drug firm of blood contamination [news]: BMJ. 1995 Mar 4;310(6979):552. Unique Identifier : AIDSLINE MED/95195530; Dolley M
Mandatory drug tests in prisons [letter]: BMJ. 1995 Mar 4;310(6979):595. Unique Identifier : AIDSLINE MED/95195546; Gore SM; Bird AG
The drugs in pregnancy service [news]: Addiction. 1995 Jan;90(1):144-5. Unique Identifier : AIDSLINE MED/95195592; Rees V
HIV transmission in prison [news]: Addiction. 1995 Jan;90(1):145. Unique Identifier : AIDSLINE MED/95195593; Rees V
User groups [news]: Addiction. 1995 Jan;90(1):145-6. Unique Identifier : AIDSLINE MED/95195594; Rees V
The social context of HIV transmission in the African-American community.: Ethn Dis. 1993 Fall;3(4):387-94. Unique Identifier : AIDSLINE MED/95195611; Lester B; Department of Social Work, Alabama State University, Montgomery; 36101.; The concept of acquired immune deficiency syndrome (AIDS) as a behavioral problem, and the emphasis placed by researchers on race and ethnicity as risk factors, have led to research focused on the risk behaviors of historically oppressed groups and a continuing social policy thrust that blames the victim. Disproportio
[Cloning and expression of a protein coding the first translation frame of the jockey mobile genetic element in E. coli]: Dokl Akad Nauk. 1994 Dec;339(6):822-5. Unique Identifier : AIDSLINE MED/95195617; Granovskii IE; Ivanova VA; Il'in IuV
Endogenous superantigens in allogeneic bone marrow transplant recipients rapidly and selectively expand donor T cells which can produce IFN-gamma.: Bone Marrow Transplant. 1994 Nov;14(5):725-35. Unique Identifier : AIDSLINE MED/95195627; Jones MS; Riley R; Hamilton BL; Paupe J; Perez D; Levy RB; Department of Microbiology and Immunology, University of Miami; School of Medicine, FL 33101.; Despite the existence of many non-MHC disparities between MHC matched but non-MHC mismatched donors and recipients, graft-versus-host disease (GVHD) is not clinically apparent following a significant number of allogeneic bone marrow transplants (BMT) in experimental animals. The present studies examined V beta TcR exp
Pathobiology of bovine leukemia virus.: Vet Res. 1994;25(6):521-36. Unique Identifier : AIDSLINE MED/95195661; Schwartz I; Levy D; URA-INRA d'Immuno-Pathologie Cellulaire et Moleculaire, Ecole; Nationale Veterinaire d'Alfort, Maisons-Alfort, France.; Bovine leukemia virus (BLV) is a retrovirus similar to the human T-cell leukemia virus (HTLV). Most BLV infected animals (70%) develop a B-cell lymphoproliferative syndrome with altered productive traits and 1 to 5% die with B-cell lymphosarcomas. Although BLV infection is world-wide, western European countries have a
Early haematological and pathological abnormalities of pathogen-free cats experimentally infected with feline immunodeficiency virus (FIV).: Vet Res. 1994;25(6):544-54. Unique Identifier : AIDSLINE MED/95195663; Femenia F; Crespeau F; Fontaine JJ; Boucheix C; Parodi AL; Laboratoire d'Anatomie Pathologique, Ecole Nationale; Veterinaire D'Alfort, Maisons-Alfort, France.; Twelve 8-12-week-old specific-pathogen-free (SPF) cats were inoculated intraperitoneally with feline immunodeficiency virus, or with blood from inoculated cats. Three cats of the same age were used as controls. All animals were sacrificed 10 weeks after inoculation. The inoculated cats seroconverted between the 3rd an
Kinetics and affinity of reactions between an antigen-specific T cell receptor and peptide-MHC complexes.: Immunity. 1994 Apr;1(1):15-22. Unique Identifier : AIDSLINE MED/95196074; Sykulev Y; Brunmark A; Jackson M; Cohen RJ; Peterson PA; Eisen HN; Center for Cancer Research, Massachusetts Institute of; Technology, Cambridge 02139.; We show here that the net rate of accumulation of complexes formed by the antigen-specific receptor of T cells (TCR) of a T cell clone with its natural ligand, an octapeptide in association with Ld, a class I protein of the major histocompatibility complex (MHC), approaches the maximal value determined by the affinity
Porcine aortic endothelial cells activate human T cells: direct presentation of MHC antigens and costimulation by ligands for human CD2 and CD28.: Immunity. 1994 Apr;1(1):57-63. Unique Identifier : AIDSLINE MED/95196079; Murray AG; Khodadoust MM; Pober JS; Bothwell AL; Molecular Cardiobiology Program, Boyer Center for Molecular; Medicine, Yale University School of Medicine, New Haven,; Connecticut 06510.; We examined the human xenoresponse to cultured porcine aortic endothelial cells (PAECs). Human CD8+ T cells proliferate to resting MHC class I-positive PAECs. CD4+ T cells proliferate after MHC class II molecules are induced with swine interferon-gamma. These responses are greater than corresponding allogeneic respons
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model.: Immunity. 1994 Jun;1(3):231-42. Unique Identifier : AIDSLINE MED/95196097; von Herrath MG; Dockter J; Oldstone MB; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California 92037.; We developed two distinct transgenic mouse models in which virus induced insulin-dependent (type 1) diabetes mellitus (IDDM). In one of these lines, the unique viral transgene was expressed in the islets of Langerhans and also in the thymus, but in the other line, expression was only in the islets. Insertion and expre
Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity.: Immunity. 1994 Jul;1(4):269-76. Unique Identifier : AIDSLINE MED/95196101; Corbella P; Moskophidis D; Spanopoulou E; Mamalaki C; Tolaini M; Itano A; Lans D; Baltimore D; Robey E; Kioussis D; Laboratory of Molecular Immunology, National Institute for; Medical Research, London, England.; Thymocyte differentiation proceeds from double positive CD4+CD8+ to single positive T cells. It has been proposed that this process occurs by an instructive or a stochastic mechanism. In this report, we show that in recombination-deficient mice (RAG-1-I-) constitutive expression of a CD8 transgene allows maturation of
Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain.: Immunity. 1994 Jul;1(4):277-85. Unique Identifier : AIDSLINE MED/95196102; Crooks ME; Littman DR; Department of Microbiology and Immunology, Howard Hughes Medical; Institute, University of California, San Francisco 94143-0414.; The CD4 and CD8 coreceptors have been shown to play significant roles in the differentiation and activation of helper and cytotoxic T lymphocytes (CTLs), respectively. Coordinate binding of coreceptor and T cell receptor (TCR) to the same major histocompatibility complex (MHC) molecule and coreceptor interaction with
Chicken pox and acute monocytic leukaemia skin lesions in an HIV-seropositive man.: Clin Exp Dermatol. 1994 Nov;19(6):505-6. Unique Identifier : AIDSLINE MED/95196388; De la Salmoniere P; Janier M; Gilquin J; Carlotti A; Sutton L; Leblond V; Daniel F; Department of Dermatology, Hopital St Joseph, Paris, France.; Lymphoid neoplasia is now well known to occur in patients with human immunodeficiency virus (HIV) infection but the first case of acute monocytic leukaemia in an HIV-seropositive man has been only recently described. We report the case of an HIV-infected patient who simultaneously developed skin lesions of acute monoc
Self-presentation can be hazardous to your health: impression management and health risk.: Health Psychol. 1994 Nov;13(6):461-70. Unique Identifier : AIDSLINE MED/95196713; Leary MR; Tchividjian LR; Kraxberger BE; Department of Psychology, Wake Forest University, Winston-Salem,; North Carolina 27109.; People s concerns with how others perceive and evaluate them can lead to behaviors that increase the risk of illness and injury. This article reviews evidence that self-presentation motives play a role in several health problems, including HIV infection; skin cancer; malnutrition and eating disorders; alcohol, tobacco
A test of the AIDS risk reduction model: psychosocial correlates of condom use in the AMEN cohort survey.: Health Psychol. 1994 Nov;13(6):548-55. Unique Identifier : AIDSLINE MED/95196723; Catania JA; Coates TJ; Kegeles S; Department of Medicine, University of California, San Francisco; 94105.; We examined the AIDS Risk Reduction Model (J. Catania, S. Kegeles, & T. Coates) in a sample of unmarried heterosexual adults with an HIV risk factor (n = 716). Labeling one s sexual behavior as risky was associated with having a history of sexually transmitted diseases, particularly
A fatal case of systemic strongyloidiasis and review of the literature.: Eur J Clin Microbiol Infect Dis. 1994 Dec;13(12):1069-74. Unique Identifier : AIDSLINE MED/95196791; Hagelskjaer LH; Danish-Bangladesh Leprosy Mission, District Nilphamari.; Systemic strongyloidiasis is a rare but serious complication of intestinal strongyloidiasis. The condition occurs mainly in immunosuppressed patients and has a significant mortality rate. A case of systemic strongyloidiasis is described in a patient who received systemic steroid treatment, and a short review of the li
Use of a constrain phage displayed-peptide library for the isolation of peptides binding to HIV-1 nucleocapsid protein (NCp7).: FEBS Lett. 1995 Mar 13;361(1):85-8. Unique Identifier : AIDSLINE MED/95196872; Lener D; Benarous R; Calogero RA; Dipartimento di Genetica, Biologia Generale e Molecolare,; Universita di Napoli Federico II, Italy.; It has been shown that peptide libraries are powerful tools for the identification of peptides showing new binding specificity. This technology was applied to the isolation of peptides binding to HIV-1 nucleocapsid protein (NCp7). Three different prolin reach peptide sequences, interacting with NCp7, were isolated, fr
Surgical emergencies in tropical gastroenterology.: Gut. 1995 Jan;36(1):9-11. Unique Identifier : AIDSLINE MED/95197086; Holcombe C; University Department of Surgery, Royal Liverpool University; Hospital.
Tobacco smoking impairs the local immunosurveillance in the uterine cervix. An immunohistochemical study.: Gynecol Obstet Invest. 1995;39(1):34-8. Unique Identifier : AIDSLINE MED/95197095; Poppe WA; Ide PS; Drijkoningen MP; Lauweryns JM; Van Assche FA; Department of Obstetrics and Gynecology, KU Leuven, Belgium.; Previous reports have supported an association between tobacco smoking and cervical neoplasia. Our observations show an association between smoking and a reduction of the numerical densities of Langerhans cells and of helper/inducer T lymphocytes in the squamous epithelia of the transformation zone of the uterine cerv
[How HIV and HBV ensure their survival in the cell. Cytotoxic T-cells are impaired in their function (news)]: Fortschr Med. 1995 Jan 30;113(3):14, 16. Unique Identifier : AIDSLINE MED/95197115; Knauer RH
Intratumoral activation of CD8-positive cytotoxic lymphocytes in acquired immunodeficiency syndrome lymphomas.: Hum Pathol. 1995 Mar;26(3):284-90. Unique Identifier : AIDSLINE MED/95197128; Devergne O; Raphael M; Autran B; Leger-Ravet MB; Coumbaras J; Crevon MC; Galanaud P; Emilie D; Departement d'Hematologie, Hopital de la Pitie, Paris,; France.; The incidence of lymphomas is unusually high in human immunodeficiency virus (HIV)-infected patients. Because cytotoxic T lymphocytes (CTL) represent a major mechanism of the antitumoral immune response in immunocompetent individuals, we asked whether intratumoral activation of CTL was impaired in acquired immune defi
Detection of Epstein-Barr virus in Hodgkin's disease occurring in an Oriental population.: Hum Pathol. 1995 Mar;26(3):314-8. Unique Identifier : AIDSLINE MED/95197133; Chan JK; Yip TT; Tsang WY; Lau WH; Wong CS; Ma VW; Department of Pathology, Queen Elizabeth Hospital, Kowloon, Hong; Kong.; Like Burkitt s lymphoma, the strength of association of Epstein-Barr virus (EBV) with Hodgkin s disease occurring in different populations and clinical settings is highly variable, being 30% to 50% in Western countries, nearly 100% in Third World countries like
Serotonin regulation of T-cell subpopulations and of macrophage accessory function.: Immunology. 1995 Jan;84(1):148-52. Unique Identifier : AIDSLINE MED/95197149; Young MR; Matthews JP; Research Service, Hines VA Hospital, Hines, Illinois.; The role of serotonin as an immune modulator was investigated by measuring the functional competence of T cells from control mice versus from mice whose intracellular stores of serotonin had been depleted by pretreatment with p-chlorophenylalanine (PCPA). While the proportions of splenic CD4+ and CD8+ T cells isolated
Effect of interleukin-10 on NF-kB and AP-1 activities in interleukin-2 dependent CD8 T lymphoblasts.: Immunol Lett. 1994 Oct;42(3):129-33. Unique Identifier : AIDSLINE MED/95197171; Hurme M; Henttinen T; Karppelin M; Varkila K; Matikainen S; Department of Biomedical Sciences, University of Tampere,; Finland.; Interleukin-10 is a multifunctional cytokine, which regulates the function of various cell types of the immune system. In CD8 T cells it is known to accelerate the interleukin-2 dependent proliferation and to induce the differentiation of these cells to active cytolytic cells. Now we have studied interleukin-10 induce
Cationization of a monoclonal antibody to the human immunodeficiency virus REV protein enhances cellular uptake but does not impair antigen binding of the antibody.: Immunol Lett. 1994 Oct;42(3):191-5. Unique Identifier : AIDSLINE MED/95197181; Pardridge WM; Bickel U; Buciak J; Yang J; Diagne A; Aepinus C; Department of Medicine, Brain Research Institute, UCLA School of; Medicine 90024.; Replication of the human immunodeficiency virus (HIV) within cells may be blocked by neutralization of viral-specific proteins that are absolutely required for growth of the virus. One such viral-specific protein is REV, and a monoclonal antibody (mAb) against the REV protein is a potential therapeutic for acquired im
Expansion of mycobacterium-reactive gamma delta T cells by a subset of memory helper T cells.: Infect Immun. 1995 Apr;63(4):1211-7. Unique Identifier : AIDSLINE MED/95197238; Vila LM; Haftel HM; Park HS; Lin MS; Romzek NC; Hanash SM; Holoshitz J; University of Michigan Specialized Center of Research in; Rheumatoid Arthritis, Department of Internal Medicine, Ann Arbor.; Human gamma delta T cells expressing the V gamma 9/V delta 2 T-cell receptor have been previously found to proliferate in response to certain microorganisms and to expand throughout life, presumably because of extrathymic activation by foreign antigens. In vitro expansion of V gamma 9/V delta 2 cells by mycobacteria h
Perceiving need for drug treatment: a look at eight hypotheses.: Int J Addict. 1994 Dec;29(14):1835-54. Unique Identifier : AIDSLINE MED/95197317; Fiorentine R; Anglin MD; UCLA Neuropsychiatric Institute, Drug Abuse Research Center; 90024.; Data from the Drug Use Forecasting Program, sponsored by the National Institute of Justice, were used to examine eight hypotheses predicting the perceived need for drug treatment among drug-using arrestees. The findings support five of the eight hypotheses, including those related to drug severity, drug type, prior tr
Countertransference issues in group psychotherapy with HIV-positive and AIDS patients.: Int J Group Psychother. 1995 Jan;45(1):91-100. Unique Identifier : AIDSLINE MED/95197327; Bernstein G; Klein R; Department of Consultation Liaison Psychiatry, Montefiore Medical; Center.; Mental health professionals are increasingly aware of the special difficulties encountered by therapists working with HIV-positive and AIDS patients. In this report, countertransference issues experienced by therapists leading a psychotherapy group for heterosexual, drug-using HIV-positive and AIDS patients in an inne
Impact of vitamin B6 status on psychological distress in a longitudinal study of HIV-1 infection.: Int J Psychiatry Med. 1994;24(3):209-22. Unique Identifier : AIDSLINE MED/95197351; Shor-Posner G; Feaster D; Blaney NT; Rocca H; Mantero-Atienza E; Szapocznik J; Eisdorfer C; Goodkin K; Baum MK; Department of Epidemiology and Public Health, University of Miami; School of Medicine, FL 33101.; OBJECTIVE: Inadequate vitamin B6 status has been associated with altered neuropsychiatric function, possibly through its effect on the metabolism of neurotransmitters, including serotonin (5-HT). The present eighteen month longitudinal study evaluated the relationship between vitamin B6 status and psychological distre
The HIV-positive psychiatric patient and the duty to protect: ethical and legal issues.: Int J Psychiatry Med. 1994;24(3):259-70. Unique Identifier : AIDSLINE MED/95197355; Searight HR; Pound P; Deaconess Family Medicine, St. Louis, Missouri.; A small, yet significant, percentage of HIV-positive patients have a concomitant psychiatric or neurological disorder associated with impaired judgment. Clinical problems such as psychoses, certain personality disorders, and dementias are associated with disinhibition of impulses and diminished capacity for self-monit
Human immunodeficiency virus and hepatitis--implications for operating room personnel.: Ir J Med Sci. 1995 Jan;164(1):12-9. Unique Identifier : AIDSLINE MED/95197400; Colbert S; Sheehan GJ; Department of Anaesthesia and Intensive Care, Mater Misericordiae; Hospital, Dublin.; Human Immunodeficiency Virus, Hepatitis B and C are important blood borne viruses and pose occupational risks for operating room personnel. Increasing numbers of patients with these infections are appearing in Irish hospitals. In this review we describe in detail the occupational risks of these blood borne viruses for
Organizational response to adolescent HIV risk.: Hawaii Med J. 1995 Jan;54(1):386-7, 392. Unique Identifier : AIDSLINE MED/95197415; Mueller C; Mann E; Bidwell R; Liebow E; Lovely R; McGrady G; Vera M; University of Hawaii, School of Social Work, Honolulu 96822.; Using semi-structured interviews, the present study examined organizational responses to adolescent HIV risk in an urban Honolulu community. All 23 health, social service, and educational organizations studied have been impacted by HIV. However, the overall organizational response has been compartmentalized and limite
All pregnant women should be tested for the human immunodeficiency virus (HIV) [editorial]: J Am Osteopath Assoc. 1995 Feb;95(2):136. Unique Identifier : AIDSLINE MED/95197430
Longer life expectancy in United States [news]: J Am Osteopath Assoc. 1995 Feb;95(2):85. Unique Identifier : AIDSLINE MED/95197431
Saliva-based HIV test approved [news]: J Am Osteopath Assoc. 1995 Feb;95(2):85. Unique Identifier : AIDSLINE MED/95197432
Brochure on pet ownership by HIV patients introduced [news]: J Am Vet Med Assoc. 1994 Oct 15;205(8):1091. Unique Identifier : AIDSLINE MED/95197437
Inhibition of HIV-1 replication and activation of RNase L by phosphorothioate/phosphodiester 2',5'-oligoadenylate derivatives.: J Biol Chem. 1995 Mar 17;270(11):5963-78. Unique Identifier : AIDSLINE MED/95197622; Sobol RW; Henderson EE; Kon N; Shao J; Hitzges P; Mordechai E; Reichenbach NL; Charubala R; Schirmeister H; Pfleiderer W; et al; Department of Biochemistry, Temple University School of Medicine,; Philadelphia, Pennsylvania 19140.; 2 ,5 -Oligoadenylate (2-5A) derivatives have been designed to act distal to the human immunodeficiency virus-1 (HIV-1)-induced blockade in the 2-5A synthetase/RNase L antiviral pathway. Stereochemical modification of individual internucleotide linkages of the 2-5A molecule was accomplished by phosphoramidite and phosp
Cultured AIDS-related Kaposi's sarcoma cells retain a proliferative bioenergetic profile but demonstrate reduced cytoprotective capabilities.: J Cell Biochem. 1994 Dec;56(4):568-81. Unique Identifier : AIDSLINE MED/95197721; Mallery SR; Ng-Bautista CL; Lantry LE; Ness GM; Hegtvedt AK; Lazo A; Bailer RT; Hout BL; Stephens RE; Brierley GP; Department of Dentistry, College of Dentistry, Ohio State; University, Columbus 43210-1241.; Features of AIDS-related Kaposi s sarcoma (AIDS-KS), such as the multifocal presentation at mucosal and epidermal sites subjected to trauma, suggest that AIDS-KS is initially a reactive hyperplasia that subsequently progresses to a neoplasia. It is recognized that there is an association between sustained inflammatory
Neuropsychological function in asymptomatic HIV-1 infection: methodological issues.: J Clin Exp Neuropsychol. 1994 Dec;16(6):898-910. Unique Identifier : AIDSLINE MED/95197730; Grunseit AC; Perdices M; Dunbar N; Cooper DA; National Centre in HIV Epidemiology and Clinical Research,; University of New South Wales, Sydney, Australia.; There have been conflicting reports as to whether significant neuropsychological deterioration occurs in asymptomatic HIV-1 infection. Comparisons among studies have been hindered by substantial variations in sample size, statistical methods, definitions of neuropsychological abnormality, and attention to potential co
Acute HIV polymyositis with complicating myoglobinuric renal failure: CT appearance.: J Comput Assist Tomogr. 1995 Mar-Apr;19(2):321-3. Unique Identifier : AIDSLINE MED/95197775; Eustace S; McEnif N; Rastegar J; Roizental M; Costello P; Department of Radiology, Brigham and Womens Hospital, Boston, MA; 02115.
Neurosyphilis.: Infect Dis Clin North Am. 1994 Dec;8(4):769-95. Unique Identifier : AIDSLINE MED/95197849; Scheck DN; Hook EW 3rd; University of Alabama School of Medicine, Birmingham.; Central nervous system invasion by Treponema pallidum, the causative agent of syphilis, occurs in many, if not most, patients with syphilis. Laboratory findings from untreated asymptomatic syphilis patients with abnormalities of cerebrospinal fluid are termed asymptomatic neurosyphilis and represent a group that has a
Antibiotics and sexually transmitted diseases.: Infect Dis Clin North Am. 1994 Dec;8(4):841-57. Unique Identifier : AIDSLINE MED/95197852; Bowie WR; University of British Columbia, Vancouver, Canada.; There have been gratifying decreases in the rates of several major treatable STDs. These decreases show that diligent application of current preventive and management approaches can be effective. These improvements have not necessarily been reflected as great changes for populations at greatest risk, particularly youn
Learning and memory in the honeybee.: J Neurosci. 1995 Mar;15(3 Pt 1):1617-30. Unique Identifier : AIDSLINE MED/95198054; Hammer M; Menzel R; Institut fur Neurobiologie, FU-Berlin, Germany.; Insects are favorable subjects for neuroethological studies. Their nervous systems are relatively small and contain many individually identifiable cells. The CNS is highly compartmentalized with clear separations between multisensory higher order neuropiles in the brain and neuropiles serving sensory-motor routines in
Department reports latest figures on AIDS and HIV cases in Oklahoma.: J Okla State Med Assoc. 1995 Feb;88(2):84. Unique Identifier : AIDSLINE MED/95198160
Current research on children's and adolescents' HIV/AIDS-related knowledge, attitudes, and behavior [editorial]: J Pediatr Psychol. 1995 Feb;20(1):37-40. Unique Identifier : AIDSLINE MED/95198179; Whitt JK
Educational options and AIDS-related behaviors among troubled adolescents.: J Pediatr Psychol. 1995 Feb;20(1):41-60. Unique Identifier : AIDSLINE MED/95198180; Slonim-Nevo V; Auslander WF; Ozawa MN; Department of Social Work, Ben-Gurion University of the Negev,; Beer Sheva, Israel.; Examined whether educational parameters could predict AIDS-related knowledge, attitude, and behavior, controlling for sociodemographic variables, among delinquent and abused adolescents. 358 adolescents, ages 11-18 years, who were placed in 15 residential centers in Midwestern cities completed self-report questionnair
Parents' contributions to children's knowledge and attitudes regarding AIDS: another look.: J Pediatr Psychol. 1995 Feb;20(1):61-77. Unique Identifier : AIDSLINE MED/95198182; Sigelman CK; Mukai T; Woods T; Alfeld C; Department of Psychology, George Washington University,; Washington, DC 20052.; Attempted to determine, using a sample of students in Grades 3, 5, and 7, whether parent-child communication about AIDS and parent knowledge of AIDS predict children s knowledge, social attitudes, and worry regarding AIDS, partially replicating tests by Sigelman, Derenowski, Mullaney, and Siders (1993) of main effects
Parental knowledge and attitudes toward children with AIDS: influences on educational policies and children's attitudes.: J Pediatr Psychol. 1995 Feb;20(1):79-90. Unique Identifier : AIDSLINE MED/95198183; Osborne ML; Kistner JA; Helgemo B; University of Pennsylvania School of Medicine.; Surveyed AIDS-related knowledge and attitudes of parents and their children to provide descriptive information on views about school policies concerning HIV-infected children and to test hypotheses regarding links between parents and children s AIDS-related knowledge and attitudes. Results indicate that parents desir
The relationship of candidiasis to linear gingival erythema in HIV-infected homosexual men and parenteral drug users.: J Periodontol. 1995 Jan;66(1):30-7. Unique Identifier : AIDSLINE MED/95198188; Grbic JT; Mitchell-Lewis DA; Fine JB; Phelan JA; Bucklan RS; Zambon JJ; Lamster IB; Division of Periodontics, Columbia University School of Dental; and Oral Surgery, New York, NY, USA.; Periodontal status was evaluated in two cohorts participating in a study of the natural history of human immunodeficiency virus (HIV) infection. One cohort consisted of 77 seropositive and 44 seronegative homosexual men, and the other cohort was comprised of 44 seropositive and 39 seronegative parenteral drug users (P
[Clostridium difficile-associated diarrhea in patients with HIV infection (letter)]: Med Clin (Barc). 1995 Feb 18;104(6):238-9. Unique Identifier : AIDSLINE MED/95198451; Morano Amado LE; de la Cruz Alvarez J; Rodriguez Mendez MJ; Medrano Martinez JC
Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma [see comments]: Lancet. 1995 Mar 25;345(8952):759-61. Unique Identifier : AIDSLINE MED/95198464; Huang YQ; Li JJ; Kaplan MH; Poiesz B; Katabira E; Zhang WC; Feiner D; Friedman-Kien AE; Department of Dermatology, New York University Medical Center,; New York 10016.; The association between a new human herpesvirus-like agent and various forms of Kaposi s sarcoma was examined by PCR. The DNA sequences of this agent were detected in 7 of 8 classic Kaposi s sarcoma specimens, 12 of 12 AIDS-associated specimens from the United States , and 7 of 10 speci
Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma [see comments]: Lancet. 1995 Mar 25;345(8952):761-2. Unique Identifier : AIDSLINE MED/95198465; Dupin N; Grandadam M; Calvez V; Gorin I; Aubin JT; Havard S; Lamy F; Leibowitch M; Huraux JM; Escande JP; et al; Laboratory of Virology, CNRS EP 57, Pite Salpetriere Hospital,; Paris, France.; DNA sequences closely related to herpesvirus-like sequences have been found in AIDS-associated Kaposi s sarcoma. Using PCR, we found herpesvirus-like DNA sequences in Kaposi s lesions and normal adjacent skin in five patients with Mediterranean Kaposi s sarcoma. We did not find these sequences in tissues from patients
Open letters to head of joint United Nations programme on AIDS [news]: Lancet. 1995 Mar 25;345(8952):782-3. Unique Identifier : AIDSLINE MED/95198472
Impact of 1993 revision of adult/adolescent AIDS surveillance case-definition for Europe. National Coordinators for AIDS Surveillance in 38 European countries [letter]: Lancet. 1995 Mar 25;345(8952):789-90. Unique Identifier : AIDSLINE MED/95198477; Ancelle-Park RA; Alix J; Downs AM; Brunet JB
Prediction of progression to AIDS with serum HIV-1 RNA and CD4 count [letter] [see comments]: Lancet. 1995 Mar 25;345(8952):790-1. Unique Identifier : AIDSLINE MED/95198478; Loveday C; Hill A
AIDS in India.: Medicine (Baltimore). 1995 Mar;74(2):107-8. Unique Identifier : AIDSLINE MED/95198529; Bartlett JG; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205.
The human immunodeficiency virus epidemic in India. Current magnitude and future projections.: Medicine (Baltimore). 1995 Mar;74(2):97-106. Unique Identifier : AIDSLINE MED/95198534; Bollinger RC; Tripathy SP; Quinn TC; Division of Infectious Diseases, Johns Hopkins Medical School,; Baltimore, Maryland 21205.; Since the first case of the human immunodeficiency virus (HIV) infection was documented in India in 1986, there has been an explosive increase in HIV transmission. In this review we describe the chronology of the HIV epidemic in India, preliminary information about the clinical pres
Pneumocystis carinii pneumonia in HIV-negative immunocompromised adults.: Med J Aust. 1995 Mar 6;162(5):233-5. Unique Identifier : AIDSLINE MED/95198591; Gerrard JG; Royal Prince Alfred Hospital, Sydney, NSW.; OBJECTIVES: To identify patient populations at risk of Pneumocystis carinii pneumonia (PCP) and assess the potential role of chemoprophylaxis. METHODS: Review of cases of PCP among patients admitted to a tertiary referral hospital in Sydney between January 1990 and April 1993. Cases were identified by indirect immunof
HIV infection among injecting drug users in the South Australian methadone program.: Med J Aust. 1995 Mar 6;162(5):242-4. Unique Identifier : AIDSLINE MED/95198593; Gaughwin MD; Ali R; Drug and Alcohol Resource Unit, Royal Adelaide Hospital,; Adelaide, SA.; OBJECTIVE: To investigate risk factors for infection with HIV among injecting drug users (IDUs) in South Australia . DESIGN: Retrospective case-control study comparing HIV-infected and uninfected IDUs who had received methadone at any time between January 1981 and June 1991. RESU
AIDS deaths on the rise [news]: Minn Med. 1995 Feb;78(2):56. Unique Identifier : AIDSLINE MED/95198644
New HIV saliva test [news]: Minn Med. 1995 Feb;78(2):56. Unique Identifier : AIDSLINE MED/95198645
Women with AIDS have worse survival rate than men [news]: Minn Med. 1995 Feb;78(2):56. Unique Identifier : AIDSLINE MED/95198646
[Detection of markers of the human T-cell leukemia virus in patients with T-cell lymphoma and Kaposi's sarcoma]: Mol Gen Mikrobiol Virusol. 1994 Sep-Oct;(5):13-7. Unique Identifier : AIDSLINE MED/95198753; Parfenova TM; Morozov VA; Il'in KV; Chistiakova IA; Samsonov VA; Averina AV; Kakezai IA; Bykovskii AF; Nine patients with Kaposi s sarcoma and five suffering from T-cell lymphoma have been examined. Antibodies to HTLV-1 were not found in these patients. The primary cellular cultures were isolated from blood and lymph nodes of the patients. Viral particles (type C) were found in the culture obtained from the patient wit
AIDS [news]: N Z Med J. 1995 Feb 8;108(993):45. Unique Identifier : AIDSLINE MED/95198981
Point/counterpoint: I. HIV-1 screening of pregnant women.: Obstet Gynecol Surv. 1995 Jan;50(1):1-2. Unique Identifier : AIDSLINE MED/95199006; Parks WP; Department of Pediatrics, New York University Medical Center, New; York.
Point/counterpoint: II. The case against mandatory prenatal HIV testing.: Obstet Gynecol Surv. 1995 Jan;50(1):2-3. Unique Identifier : AIDSLINE MED/95199007; Minkoff H; Department of Obstetrics and Gynecology, State University of New; York Health Science at Brooklyn.
Replacing ganciclovir implants.: Ophthalmology. 1995 Mar;102(3):388-92. Unique Identifier : AIDSLINE MED/95199017; Morley MG; Duker JS; Ashton P; Robinson MR; Center for Eye Research, Harvard Medical School, Boston.; PURPOSE: The authors report their surgical experience replacing empty ganciclovir implants in patients with acquired immune deficiency syndrome (AIDS)-related cytomegalovirus ( CMV ) retinitis. METHODS: A chart review of all pa
A practical approach to the diagnosis of renal disease by biopsy [see comments]: Pathology. 1994 Oct;26(4):370-96. Unique Identifier : AIDSLINE MED/95199077; Yong JL; Warren BA; Department of Anatomical Pathology, Prince Henry Hospital, Little; Bay, New South Wales.; The pathologist has an important role in the diagnosis and monitoring of renal disease. However, for optimal useful information to be derived from renal biopsy specimens, certain guidelines must be adhered to and these are enunciated here. The 3 avenues of observation of renal biopsies viz. light microscopy, immunoflu
Membranous glomerulonephritis associated with hepatitis C virus infection in an adolescent.: Pathology. 1994 Oct;26(4):399-402. Unique Identifier : AIDSLINE MED/95199079; Romas E; Power DA; Machet D; Powell H; d'Apice AJ; Department of Clinical Immunology, St Vincent's Hospital,; Fitzroy.; The clinical, laboratory and pathological findings are reported in an adolescent patient with hyper-IgM immunodeficiency syndrome (dysgammaglobulinemia) which was complicated by primary sclerosing cholangitis and membranous glomerulonephritis. Hepatitis C virus (HCV) RNA was detected in serum by the polymerase chain r
Phytohemagglutinin-inducible p24 in peripheral blood mononuclear cells as a predictor of human immunodeficiency virus type 1 vertical transmission and infant clinical status.: Pediatr Infect Dis J. 1994 Dec;13(12):1079-82. Unique Identifier : AIDSLINE MED/95199117; Farley JJ; Bauer G; Johnson JP; Cole GA; Department of Pediatrics, University of Maryland School of; Medicine, Baltimore 21201.; We sought to determine whether the detectability of phytohemagglutinin-inducible p24 (PHA-p24) in short term cultures of peripheral blood mononuclear cells correlates with an increased risk of vertical transmission among human immunodeficiency virus type 1 (HIV-1)-infected pregnant women and more severe symptomatology
Early detection of human immunodeficiency virus type 1 infection in Australian infants at risk of perinatal infection and factors affecting transmission.: Pediatr Infect Dis J. 1994 Dec;13(12):1083-90. Unique Identifier : AIDSLINE MED/95199118; Palasanthiran P; Ziegler JB; Dwyer DE; Robertson P; Leigh D; Cunningham AL; Prince of Wales Children's Hospital, Sydney, Australia.; The earliest, most reliable methods for detecting human immunodeficiency virus type 1 (HIV-1) infection in infants at risk of perinatal HIV-1 and risks for transmission were investigated. Fifteen infants were followed prospectively from birth to age 21 to 48 months. Epidemiologic data on mothers during pregnancy were
Progression of human immunodeficiency virus disease among infants and children infected perinatally with human immunodeficiency virus or through neonatal blood transfusion. Los Angeles County Pediatric AIDS Consortium and the Los Angeles County-University of Southern California Medical Center and the University of Southern California School of Medicine [see comments]: Pediatr Infect Dis J. 1994 Dec;13(12):1091-7. Unique Identifier : AIDSLINE MED/95199119; Frederick T; Mascola L; Eller A; O'Neil L; Byers B; Pediatric AIDS Surveillance Study (PASS), Los Angeles County; Department of Health Services, CA 90012.; Using community-based surveillance data for pediatric human immunodeficiency virus (HIV) infection, we examined disease progression using survival analysis among perinatally HIV-infected children and children HIV-infected through a neonatal blood transfusion. As of December 31, 1991, 238 HIV-infected children (classif
Intracerebral Mycobacterium avium-intracellulare in a child with acquired immunodeficiency syndrome.: Pediatr Infect Dis J. 1994 Dec;13(12):1149-51. Unique Identifier : AIDSLINE MED/95199132; Dwork AJ; Chin S; Boyce L; Department of Pathology (Division of Neuropathology), College of; Physicians and Surgeons of Columbia University, New York, NY.
Human immunodeficiency virus-associated hemophagocytic syndrome in children [letter]: Pediatr Infect Dis J. 1994 Dec;13(12):1159. Unique Identifier : AIDSLINE MED/95199139; Dalle JH; Dollfus C; Courpotin C; Tabone AM; Landman-Parker J; Leverger G; Lasfargues G
[Clinical findings and follow-up of 100 each HIV-negative and HIV-positive cases of bacillary pulmonary tuberculosis in Rwanda]: Pneumologie. 1995 Jan;49(1):27-31. Unique Identifier : AIDSLINE MED/95199202; Muhlberger F; Nturanye F; Ladner J; Sanatorium Gishari.; This prospective randomised study compares 100 each HIV negative und HIV positive patients suffering from pulmonary tuberculosis, under hospital conditions. Both groups are similar in respect of age and sex. Tuberculin anergy exists in 24% of the patients of the HIV positive group. Symptomatology and complaints are an
Myosin-actin interaction plays an important role in human immunodeficiency virus type 1 release from host cells.: Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2026-30. Unique Identifier : AIDSLINE MED/95199286; Sasaki H; Nakamura M; Ohno T; Matsuda Y; Yuda Y; Nonomura Y; Division of Morphology, Jikei University School of Medicine,; Tokyo, Japan.; We examined the potential role of myosin and actin in the release of human immunodeficiency virus type 1 (HIV-1) from infected cells. Wortmannin (100 nM to 5 microM), an effective inhibitor of myosin light chain kinase, blocked the release of HIV-1 from infected T-lymphoblastoid and monocytoid cells in a concentration
Sequestration of anti-platelet GPIIIa antibody in rheumatoid factor immune complexes of human immunodeficiency virus 1 thrombocytopenic patients.: Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2263-7. Unique Identifier : AIDSLINE MED/95199332; Karpatkin S; Nardi MA; Hymes KB; Department of Medicine, New York University Medical School, NY; 10016.; Human immunodeficiency virus 1-related idiopathic thrombocytopenic purpura (HIV-1-ITP) patients have a 4-fold increased percentage of CD5+ B cells and a 4.8-fold increased percentage of serum immune complexes precipitated by polyethylene glycol (PEG-ICs) compared to control subjects, as reported previously. Since CD5+
The RNA element encoded by the trans-activation-responsive region of human immunodeficiency virus type 1 is functional when displaced downstream of the start of transcription.: Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2408-12. Unique Identifier : AIDSLINE MED/95199359; Churcher MJ; Lowe AD; Gait MJ; Karn J; Medical Research Council Laboratory of Molecular Biology,; Cambridge, United Kingdom.; The human immunodeficiency virus type 1 (HIV-1) trans-activator protein, Tat, specifically stimulates transcription from the viral long terminal repeat. Tat binds to an RNA stem-loop structure encoded by the trans-activation response region (TAR). To test whether TAR is functional when displaced downstream of the star
Is homosexual behaviour hard-wired? Sexual orientation and brain structure [editorial]: Psychol Med. 1994 Nov;24(4):811-6. Unique Identifier : AIDSLINE MED/95199430; Harrison PJ; Everall IP; Catalan J
A longitudinal study of the neuropsychiatric consequences of HIV-1 infection in gay men. I. Neuropsychological performance and neurological status at baseline and at 12-month follow-up.: Psychol Med. 1994 Nov;24(4):885-9. Unique Identifier : AIDSLINE MED/95199436; Burgess AP; Riccio M; Jadresic D; Pugh K; Catalan J; Hawkins DA; Baldeweg T; Lovett E; Gruzelier J; Thompson C; Academic Department of Psychiatry, Charing Cross and Westminster; Medical School, Chelsea and Westminster Hospital, London.; The aim of this study was to determine whether HIV infection is associated with neurological or neuropsychological impairment in the asymptomatic and early symptomatic stages of disease. Subjects included 61 gay men (41 HIV-, 20 HIV+) who were assessed at the time of requesting their first HIV test and again 12 months
A longitudinal study of the neuropsychiatric consequences of HIV-1 infection in gay men. II. Psychological and health status at baseline and at 12-month follow-up.: Psychol Med. 1994 Nov;24(4):897-904. Unique Identifier : AIDSLINE MED/95199437; Pugh K; Riccio M; Jadresic D; Burgess AP; Baldeweg T; Catalan J; Lovett E; Hawkins DA; Gruzelier J; Thompson C; Academic Department of Psychiatry, Charing Cross and Westminster; Medical School, Chelsea and Westminster Hospital, London.; The aim of this study was to determine whether HIV infection is associated with increased psychosocial distress in the asymptomatic and early symptomatic stages of disease and to determine the factors associated with reporting health symptoms. Subjects included 61 gay men (41 HIV--, 20 HIV+) who were assessed at the t
AIDS dementia complex: evaluation with proton MR spectroscopic imaging.: Radiology. 1995 Apr;195(1):58-64. Unique Identifier : AIDSLINE MED/95199582; Barker PB; Lee RR; McArthur JC; Department of Radiology, Johns Hopkins University Schools of; Medicine and Public Health, Baltimore, Md.; PURPOSE: To investigate cerebral metabolic changes in acquired immunodeficiency syndrome dementia complex (ADC) with proton magnetic resonance (MR) spectroscopic imaging and compare the findings with those of conventional MR imaging. MATERIALS AND METHODS: Seven patients with ADC (
[Medical and social factors in the orientation of patients with AIDS after discharge]: Rev Epidemiol Sante Publique. 1995;43(1):37-47. Unique Identifier : AIDSLINE MED/95199603; Poisson-Salomon AS; Mayaud C; Blum-Boisgard C; Service de l'evaluation, D.P.I.M. AP-HP, Paris.; The objectives of this cohort survey performed in acute care patients were to identify and to describe HIV patients needing long-term care with or without daily assistance (home care of health care institutions). This exhaustive sample was recruited from among the hospitalized AIDS patients of fifteen departments of A
Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques [see comments]: Science. 1995 Mar 24;267(5205):1820-5. Unique Identifier : AIDSLINE MED/95199707; Baba TW; Jeong YS; Pennick D; Bronson R; Greene MF; Ruprecht RM; Department of Pediatrics, Tufts University School of Medicine,; Boston, MA 02111.; Adult macaques do not develop disease after infection with a nef deletion mutant of the simian immunodeficiency virus (SIV) and are protected against challenge with pathogenic virus. This finding led to the proposal to use nef-deleted viruses as live, attenuated vaccines to prevent human acquired immunodeficiency synd
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity.: Verh K Acad Geneeskd Belg. 1994;56(6):561-92. Unique Identifier : AIDSLINE MED/95199863; Neyts J; De Clercq E; Rega Institute for Medical Research, Katholieke Universiteit; Leuven.; Human cytomegalovirus (HCMV) infections are a major cause of mortality and morbidity in human transplant recipients and a serious problem in patients with AIDS. Furthermore, CMV is the most frequent viral cause of congenital abnormalities. Two drugs are currently licensed for the t
AIDS presenting as progressive multifocal leukoencephalopathy with clinical response to zidovudine.: Acta Neurol Scand. 1994 Dec;90(6):443-7. Unique Identifier : AIDSLINE MED/95199879; Singer EJ; Stoner GL; Singer P; Tomiyasu U; Licht E; Fahy-Chandon B; Tourtellotte WW; Neurology Service, VAMC West Los Angeles, CA 90073.; Progressive multifocal leukoencephalopathy (PML) due to JC virus can be the initial manifestation of AIDS. A 40-year-old man seropositive for HIV-1 presented with aphasia, hemiparesis, and hemianopsia, and with magnetic resonance imaging of the brain typical of PML. He quickly became bed bound, incontinent, and mute.
Inner-city youths and condom use: health beliefs, clinic care, welfare, and the HIV epidemic.: Adolescence. 1994 Winter;29(116):805-20. Unique Identifier : AIDSLINE MED/95199907; Stiffman AR; Dore P; Cunningham RM; George Warren Brown School of Social Work, Washington University,; St. Louis, Missouri 63130-4899.; This paper examines questions concerning condom use and determinants of change in use by inner-city youths who appear to be in the direct path of the AIDS epidemic. Detailed information gathered in interviews with 548 youths in 1989-90 and 1991-92, provide a history of change in condom use and HIV-related high-risk be
The impact of human immunodeficiency virus infection on pelvic inflammatory disease: a case-control study in Abidjan, Ivory Coast.: Am J Obstet Gynecol. 1995 Mar;172(3):919-25. Unique Identifier : AIDSLINE MED/95200004; Kamenga MC; De Cock KM; St. Louis ME; Toure CK; Zakaria S; N'gbichi JM; Ghys PD; Holmes KK; Eschenbach DA; Gayle HD; et al; Department of Epidemiology, University of Washington, Seattle; 98195.; OBJECTIVE: Our purpose was to assess the impact of human immunodeficiency virus infection on pelvic inflammatory disease. STUDY DESIGN: A case-control study was performed in Abidjan, Ivory Coast , women with pelvic inflammatory disease, 57 seropositive and 113 seronegative for
[Male urethritis]: Ann Urol (Paris). 1994;28(6-7):330-3. Unique Identifier : AIDSLINE MED/95200246; Bohbot JM; Institut Alfred-Fournier, Paris.; The incidence of sexually transmitted diseases (STD) is decreasing, but often take on a more subacute form, which may be difficult to detect. Acute gonococcal urethritis, diagnosed by direct examination and culture (with antibiotic susceptibility testing) requires immediate single-dose treatment. Chlamydia trachomatis
Genetic variability of the human immunodeficiency virus: statistical and biological issues.: Annu Rev Genet. 1994;28:559-96. Unique Identifier : AIDSLINE MED/95200269; Seillier-Moiseiwitsch F; Margolin BH; Swanstrom R; Department of Biostatistics, University of North Carolina, Chapel; Hill 27599-7400.
EEG and dementia indicators in AIDS patients' Rorschach test.: Arq Neuropsiquiatr. 1994 Sep;52(3):314-9. Unique Identifier : AIDSLINE MED/95200332; do Prado GF; Carvalho LB; da Silva AB; Lima JG; Discipline of Neurology, Escola Paulista de Medicina (EPM), Sao; Paulo, Brasil.; We studied the EEG and Rorschach test (RT) of nineteen AIDS patients and eight normal people in the same age group. Eight patients presented slow alpha rhythms (8 to 9 Hz); three, not-slow alpha rhythms (> 9 to 13 Hz); and eight, beta rhythms in background activity. Paroxystic activity, characterized by diffuse theta
[HTLV-1 associated myelopathies in the city of Salvador, Bahia]: Arq Neuropsiquiatr. 1994 Sep;52(3):320-5. Unique Identifier : AIDSLINE MED/95200333; Melo A; Gomes I; Mattos K; Unidade de Neuroinfectologia, Universidade Federal da Bahia; (UFBA), Salvador, Brasil.; Chronic myelopathy associated with human T-lymphotropic virus type I (HTLV-I) has been described in several endemic areas in Brazil . In Salvador, 102 patients with myelopathy were screened for HTLV-I/II by ELISA and Western blot assays. We found 36 patients with HTLV-I/II associate
[HTLV-I-associated myelopathy: a systemic disease]: Arq Neuropsiquiatr. 1994 Sep;52(3):443-4. Unique Identifier : AIDSLINE MED/95200355; Melo A; Gomes I; Mattos K; Unidade de Neuroinfectologia, Universidade Federal da Bahia; (UFBA), Salvador, Brasil.; Chronic myelopathy associated with T-lymphotropic virus type I (HAM) has been described as an endemic disease in several areas of the world mainly in Asia, Africa and Latin America. The involvement of the central and the peripheral nervous system by HTLV-I observed in South America and Africa points out that this dise
Halogenated isoniazid derivatives as possible antimycobacterial and anti-HIV agents--III.: Farmaco. 1994 Dec;49(12):775-81. Unique Identifier : AIDSLINE MED/95200460; Vigorita MG; Ottana R; Zappala C; Maccari R; Pizzimenti FC; Gabbrielli G; Dipartimento Farmaco-Chimico, Facolta di Farmacia, Villaggio SS.; Annunziata, Messina, Italy.; As part of a research directed to the synthesis of novel isoniazid derivatives with potential activity on mycobacteria and HIV virus, the acetophenone-isonicotinoylhydrazones 3 and the 4-aryl-1-methoxy-1-(4-pyridyl)- 2,3-diaza-1,3-butadienes 5, obtained by reaction between isonicotinoylhydrazones and diazomethane, hav
Compliance in clinical trials [editorial]: AIDS. 1995 Jan;9(1):1-10. Unique Identifier : AIDSLINE MED/95200563; Besch CL
Pneumocystis carinii pneumonia prophylaxis remains unchallenged [letter; comment]: AIDS. 1995 Jan;9(1):100. Unique Identifier : AIDSLINE MED/95200564; Teira R; Virosta M
Fluconazole prophylaxis in AIDS: the jury is not yet out [letter; comment]: AIDS. 1995 Jan;9(1):101. Unique Identifier : AIDSLINE MED/95200565; Flanigan TP
Statistics from the Centers for Disease Control and Prevention [letter]: AIDS. 1995 Jan;9(1):103-5. Unique Identifier : AIDSLINE MED/95200566
V3 sequences in primary HIV-1 infection.: AIDS. 1995 Jan;9(1):11-7. Unique Identifier : AIDSLINE GENBANK/U10980; Antonioli IM; Baumberger C; Yerly S; Perrin L; Department of Medicine, Geneva University Hospital, Switzerland.; OBJECTIVE: To determine HIV-1 genomic RNA and proviral DNA sequences of the third hypervariable region (V3 loop) of the envelope protein in patients with primary HIV-1 infection (PHI), and to compare these sequences with sequences from patients with more advanced HIV-1 infection. METHODS: Sera and peripheral blood mon
Interaction of several complement proteins with gp120 and gp41, the two envelope glycoproteins of HIV-1.: AIDS. 1995 Jan;9(1):19-26. Unique Identifier : AIDSLINE MED/95200568; Stoiber H; Ebenbichler C; Schneider R; Janatova J; Dierich MP; Ludwig Boltzmann Institute for AIDS Research, University of; Innsbruck, Austria.; OBJECTIVE: To study the binding of human complement proteins to gp41 and gp120 of HIV-1. METHODS: The interaction of complement proteins with gp41 and gp120 and their effect on the gp41-gp120 complex in enzyme-linked immunosorbent assays (ELISA) and on stably transfected Schneider-2 cells expressing a gp41-gp120 compl
Antibodies to the putative SIV infection-enhancing domain diminish beneficial effects of an SIV gp160 vaccine in rhesus macaques.: AIDS. 1995 Jan;9(1):27-34. Unique Identifier : AIDSLINE MED/95200569; Mitchell WM; Torres J; Johnson PR; Hirsch V; Yilma T; Gardner MB; Robinson WE Jr; Department of Pathology, Vanderbilt University, Nashville,; Tennessee.; OBJECTIVE: To demonstrate that antibodies against amino acids (aa) 603-622 of the SIV gp41 transmembrane glycoprotein enhance infection of SIV in vivo. DESIGN: A synthetic peptide derived from aa 603-622 of SIVmac251 gp41 was synthesized and tested for immunogenicity in rabbits and SIV-infected rhesus macaques. Next,
Glucocorticoids rescue CD4+ T lymphocytes from activation-induced apoptosis triggered by HIV-1: implications for pathogenesis and therapy.: AIDS. 1995 Jan;9(1):35-42. Unique Identifier : AIDSLINE MED/95200570; Lu W; Salerno-Goncalves R; Yuan J; Sylvie D; Han DS; Andrieu JM; Laboratory of Tumour Immunology, Laennec Hospital, Necker; Faculty of Medicine, Rene Descartes University, Paris, France.; OBJECTIVE: During HIV-1 infection, CD4+ T lymphocytes migrate to immune-reactive lymphoid organs where they are infected by the virus and/or killed by apoptosis on immunoregulatory stimuli--a potential mechanism underlying fatal CD4+ T-cell depletion observed in AIDS. This study seeks to determine the effects of gluco
Cytotoxic T-lymphocyte induction in asymptomatic HIV-1-infected patients immunized with Retrovector-transduced autologous fibroblasts expressing HIV-1IIIB Env/Rev proteins.: AIDS. 1995 Jan;9(1):43-50. Unique Identifier : AIDSLINE MED/95200571; Ziegner UH; Peters G; Jolly DJ; Mento SJ; Galpin J; Prussak CE; Barber JR; Hartnett DE; Bohart C; Klump W; et al; Viagene, Inc., San Diego, CA 92121; OBJECTIVE: To demonstrate the safety and enhancement of HIV-1-specific immune responses in HIV-infected asymptomatic patients following treatment with retroviral vector (Retrovector)-transduced autologous fibroblasts (VTAF) expressing HIV-1IIIB Env/Rev proteins. DESIGN: A non-placebo-controlled, single arm Phase I stu
Effect of sex, age and transmission category on the progression to AIDS and survival of zidovudine-treated symptomatic patients.: AIDS. 1995 Jan;9(1):51-6. Unique Identifier : AIDSLINE MED/95200572; Vella S; Giuliano M; Floridia M; Chiesi A; Tomino C; Seeber A; Barcherini S; Bucciardini R; Mariotti S; Laboratory of Virology, Istituto Superiore di Sanita, Rome,; Italy.; OBJECTIVE: To evaluate the effect of transmission category and demographic, clinical and immunological characteristics on the progression to AIDS and survival of zidovudine-treated patients. DESIGN: Prospective multicentre cohort study of symptomatic non-AIDS patients. SETTING: Eighty-three clinical centres reporting
The role of initial AIDS-defining illness in survival following AIDS.: AIDS. 1995 Jan;9(1):57-63. Unique Identifier : AIDSLINE MED/95200573; Luo K; Law M; Kaldor JM; McDonald AM; Cooper DA; National HIV Surveillance Committee, University of New South; Wales, Sydney, Australia.; OBJECTIVE: To examine the role of initial AIDS-defining illness in survival following AIDS and survival trends over time. DESIGN: States and Territory Health Departments notified new diagnoses of AIDS to the National AIDS Registry. Information on vital status and date of last medical contact was sought annually. METHO
A population-based comparison of the clinical course of children and adults with AIDS.: AIDS. 1995 Jan;9(1):65-72. Unique Identifier : AIDSLINE MED/95200574; Turner BJ; Eppes S; McKee LJ; Cosler L; Markson LE; Division of General Internal Medicine, Jefferson Medical College,; Philadelphia, Pennsylvania.; OBJECTIVE: To examine the association of clinical complications and age at diagnosis with survival for a cohort of children and adults with AIDS. DESIGN: A population-based analysis of 734 children and 5584 adults diagnosed with AIDS from 1985 to 1990 in New York State. RESULTS: The initial AIDS-defining diagnoses for
Long-term changes in psychological symptomatology associated with HIV serostatus among male injecting drug users.: AIDS. 1995 Jan;9(1):73-9. Unique Identifier : AIDSLINE MED/95200575; Davis RF; Metzger DS; Meyers K; McLellan AT; Mulvaney FD; Navaline HA; Woody GE; Department of Veterans Affairs Medical Center, Philadelphia,; Pennsylvania.; OBJECTIVE: To examine long-term changes in psychological symptomatology from 6 to 24 months after notification of HIV serostatus among male injecting drug users (IDU). DESIGN: Self-report and interview data were collected at 6-month intervals as part of a longitudinal study monitoring HIV infection and risk-associated
Hours at work and employment status among HIV-infected patients.: AIDS. 1995 Jan;9(1):81-8. Unique Identifier : AIDSLINE MED/95200576; Leigh JP; Lubeck DP; Farnham PG; Fries JF; Department of Economics, San Jose State University, CA; 95192-0114.; OBJECTIVE: To study differences in employment and work hours among three groups of HIV-infected and non-infected individuals. METHODS: Data on 1263 patients seen in five different sites in California were drawn from the AIDS Time-Oriented Health Outcome Study. Three groups of patients were examined: AIDS patients, HIV
In vivo inhibition of syncytium-inducing variants of HIV in patients treated with didanosine [letter]: AIDS. 1995 Jan;9(1):89-90. Unique Identifier : AIDSLINE MED/95200577; Delforge ML; Liesnard C; Debaisieux L; Tchetcheroff M; Farber CM; Van Vooren JP
Autologous neutralizing antibodies and viral load in HIV-2-infected individuals [letter]: AIDS. 1995 Jan;9(1):90-1. Unique Identifier : AIDSLINE MED/95200578; Tamalet C; Simon F; Dhiver C; Matheron S; de Micco P; Gastao JA; Brun-Vezinet F
HIV-1 cross-neutralizing antibodies in German HIV-1-infected patients do not correlate with an antibody-binding pattern against different HIV-1 isolates [letter]: AIDS. 1995 Jan;9(1):91-3. Unique Identifier : AIDSLINE MED/95200579; Jurkiewicz E; Petry H; Sutor GC; Lang S; Schedel I; Hunsmann G
HIV-1 seroconversion after 20 months of age in a cohort of breastfed children born to HIV-1-infected women in Rwanda [letter]: AIDS. 1995 Jan;9(1):93-4. Unique Identifier : AIDSLINE MED/95200580; Bulterys M; Chao A; Dushimimana A; Saah A
Rapid development of AIDS in an HIV-1-antibody-negative homosexual man [letter]: AIDS. 1995 Jan;9(1):95-6. Unique Identifier : AIDSLINE MED/95200581; Martin-Rico P; Pedersen C; Skinhoj P; Nielsen C; Lindhardt BO
Leishmaniasis as a cause of oral disease in HIV infection [letter]: AIDS. 1995 Jan;9(1):96-8. Unique Identifier : AIDSLINE MED/95200582; Banuls J; Boix V; Portilla J; Silvestre JF
Individual variability in the reliability of CD4+ cell counts [letter] [see comments]: AIDS. 1995 Jan;9(1):98-9. Unique Identifier : AIDSLINE MED/95200583; Vedhara K; Nott KH; Richards SM
Epstein-Barr virus-encoded latent membrane protein-1 expression as prognostic factor in AIDS-related non-Hodgkin's lymphoma [letter]: AIDS. 1995 Jan;9(1):99-100. Unique Identifier : AIDSLINE MED/95200584; Tirelli U; Serraino D; Spina M; Carbone A
Factors associated with dentists' willingness to treat high-risk patients [see comments]: Br Dent J. 1995 Feb 25;178(4):145-8. Unique Identifier : AIDSLINE MED/95200704; Wilson NH; Burke FJ; Cheung SW; Department of Restorative Dentistry, University Dental Hospital; of Manchester.; The attitude of dentists in England and Wales to treatment of patients at high risk to HIV/HBV was tested by means of a postal questionnaire distributed to 1950 dentists randomly selected from those practising within the NHS Regulations. The response rate was 61%, with 52% of respondents indicating that they treated p
Severity index scores correlate with survival of AIDS patients.: Am J Hosp Palliat Care. 1994 May-Jun;11(3):4-9. Unique Identifier : AIDSLINE MED/95200714; Kinzbrunner B; Pratt MM; A major concern of hospices treating AIDS patients is survival prognosis. Patients are eligible for government hospice benefits only if they are in the last six months of life, but for AIDS patients who present at different disease stages, it is often difficult to predict survival. We have tested an index of AIDS seve
[Treatment and prevention of Mycobacterium avium complex infection in AIDS]: Ann Ital Med Int. 1994 Oct-Dec;9(4):249-54. Unique Identifier : AIDSLINE MED/95200771; Famularo G; De Simone C; Tzantzoglou S; Coco F; Cattedra di Medicina Interna, Universita degli Studi de; L'Aquila.; Since Mycobacterium avium complex (MAC) infects most, if not all, HIV-positive patients, effective regimens for its treatment and prophylaxis are a necessity. We review here the available literature in an attempt to establish clear-cut criteria for the administration of antibiotics and immunotherapy and for the prophy
Pharmacokinetics of co-administered didanosine and stavudine in HIV-seropositive male patients.: Br J Clin Pharmacol. 1994 Nov;38(5):405-10. Unique Identifier : AIDSLINE MED/95200775; Seifert RD; Stewart MB; Sramek JJ; Conrad J; Kaul S; Cutler NR; California Clinical Trials, Beverly Hills.; The pharmacokinetics of single and co-administered didanosine and stavudine were evaluated in 10 HIV-seropositive subjects in an open, within subject design in which each subject received each of three treatments. Single doses of didanosine 100 mg wer
Testing for HIV infection among individuals with tuberculosis. A joint statement of the WHO Tuberculosis Programme and the Global Programme on AIDS.: Wkly Epidemiol Rec. 1995 Feb 17;70(7):50-2. Unique Identifier : AIDSLINE MED/95200792
[Neurologic manifestations of varicella herpes zoster infection]: Enferm Infecc Microbiol Clin. 1995 Jan;13(1):6-11. Unique Identifier : AIDSLINE MED/95201005; de Otero J; Surinach JM; Ribera E; Alegre J; Juste C; Rio J; Unidad de Enfermedades Infecciosas, Hospital General Universitari; de la Vall d'Hebron, Universidad Autonoma, Barcelona.; BACKGROUND: The aim of the present study was to analyze the clinical characteristics and fluid alterations in neurologic infection by varicella herpes zoster virus in hospitalized patients. METHODS: A retrospective study of the cases with neurologic involvement by the varicella herpes zoster virus in patients admitted
[Tuberculous splenic abscess in patients with AIDS: 2 new cases (letter)]: Enferm Infecc Microbiol Clin. 1995 Jan;13(1):65. Unique Identifier : AIDSLINE MED/95201008; Fuertes Martin A; Santana Garcia S; Martin Sanchez MJ; Jimenez Lopez A
Molecular and virological effects of intracellular anti-Rev single-chain variable fragments on the expression of various human immunodeficiency virus-1 strains.: Hum Gene Ther. 1994 Nov;5(11):1315-24. Unique Identifier : AIDSLINE MED/95201015; Duan L; Zhang H; Oakes JW; Bagasra O; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, PA 19107.; A variety of genetic therapies or intracellular immunization techniques hold promise as modalities to inhibit human immunodeficiency virus type 1 (HIV-1) replication in vivo. We have recently demonstrated that a single-chain variable fragment (SFv) construct, derived from a monoclonal antibody that binds to the HIV-1
An observational study of 11 French liver transplant recipients infected with human immunodeficiency virus type 1.: Clin Infect Dis. 1994 Nov;19(5):854-9. Unique Identifier : AIDSLINE MED/95201084; Bouscarat F; Samuel D; Simon F; Debat P; Bismuth H; Saimot AG; Service des Maladies Infectieuses et Tropicales, Hopital; Bichat-Claude Bernard, Paris, France.; We report the clinical and biological course of infection with human immunodeficiency virus (HIV) type 1 in 11 liver transplant recipients who acquired this infection between 1985 and 1987. Eight patients were infected by blood or blood products from graft-related transfusions and one by the graft itself; the remainin
Salmonellal splenic abscess in the antibiotic era: a Latin American perspective.: Clin Infect Dis. 1994 Nov;19(5):871-5. Unique Identifier : AIDSLINE MED/95201087; Torres JR; Gotuzzo E; Isturiz R; Elster C; Wolff M; Northland R; Christenson B; Clara L; Instituto de Medicina Tropical, Universidad Central de Venezuela,; Caracas.; Ten cases of salmonellal splenic abscesses recently documented in various Latin American countries are discussed. All patients were adults; the mean age was 32.6 years, and there was a predominance of males (seven). Predisposing conditions were identified in four cases. All 10 cases were documented by diagnostic imagi
Drug susceptibility of Mycobacterium tuberculosis isolates from recent Haitian migrants: correlation with clinical response.: Clin Infect Dis. 1994 Nov;19(5):938-40. Unique Identifier : AIDSLINE MED/95201098; Malone JL; Paparello SF; Malone JD; Hill HE; Conrad KA; Myers JW; Lillibridge SR; Weiss PJ; Infectious Diseases Division, National Naval Medical Center,; Bethesda, Maryland 20889-5600.; Between November 1991 and June 1993, approximately 11,000 Haitian migrants were screened for active tuberculosis and human immunodeficiency virus type 1 (HIV-1) infection at the U.S. Naval Base in Guantanamo Bay, Cuba . Cultures of specimens from 37 of these patients yielded Mycobacte
Tuberculous bronchoesophageal fistulae in patients infected with the human immunodeficiency virus: three case reports and review.: Clin Infect Dis. 1994 Nov;19(5):954-7. Unique Identifier : AIDSLINE MED/95201103; Porter JC; Friedland JS; Freedman AR; Division of Medicine, St. George's Hospital Medical School,; London, England.; To our knowledge,
Mycobacterium kansasii pericarditis in patients with AIDS.: Clin Infect Dis. 1994 Nov;19(5):967-9. Unique Identifier : AIDSLINE MED/95201107; Moreno F; Sharkey-Mathis PK; Mokulis E; Smith JA; Department of Medicine, University of Texas Health Science Center; at San Antonio 78284-7881.; Pericardial effusion has been reported to occur in up to 38% of patients with AIDS. Many different etiologies for pericarditis have been described. In some instances, such infections have caused severe hemodynamic complications and life-threatening conditions. Mycobact