Interleukin-6 (IL-6) and AIDS-Kaposi's sarcoma: a nested case-control study within the multicenter aids cohort study (MACS). NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Click here to return to AIDSLINE main menu
DonateNow
Print this Article


Interleukin-6 (IL-6) and AIDS-Kaposi's sarcoma: a nested case-control study within the multicenter aids cohort study (MACS).

Diss Abstr Int [B]; 55(3):843 1994. Unique Identifier : AIDSLINE ICDB/95607535
Dourado MIC; Univ. of California, Los Angeles

Abstract: Since the beginning of the AIDS epidemic, a large research activity has focused on the etiology of Kaposi's sarcoma (KS) among HIV infected individuals. There are several hypothesized risk factors for AIDS-KS. However, there is not enough evidence supporting the existing hypotheses. Recently, a number of studies have confirmed that HIV or HIV encoded products can interact with human cells to produce immune cytokines. One of these cytokines is known as interleukin 6 (IL-6). In vitro observations have indicated that AIDS-KS cells can produce and respond to significant levels of IL-6. In addition, preliminary data suggest that IL-6 may be elevated among HIV infected individuals that subsequently develop AIDS-KS. The objective of this study was to investigate if elevated levels of IL-6 are associated with an increased incidence of AIDS-KS compared to other AIDS-defining illnesses such as opportunistic infections (OIs). We found that IL-6 levels were more prevalent among OIs than among AIDS-KS: OR was 0.4 (95% CI 0.2-0.9). The higher prevalence of IL-6 among controls could be explained by the association of higher levels of IL-6 with lower levels of CD4 T cell number. IL-6 might be a marker of immune dysfunction among HIV infected individuals. (Full text available from University Microfilms International, Ann Arbor, MI, as Order No. AAD94-20500)
Keywords: Acquired Immunodeficiency Syndrome/COMPLICATIONS/*METABOLISM Case-Control Studies Human Interleukin-6/*METABOLISM Sarcoma, Kaposi's/ETIOLOGY/*METABOLISM THESISKWDacquiredimmunodeficiencysyndrome/complications/KWDmetabolismcase-controlstudieshumaninterleukin-6/KWDmetabolismsarcoma,kaposi's/etiology/KWDmetabolismthesis
950730
M9570946

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1995. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1995. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .