AIDS-related Kaposi's sarcoma is a clonal neoplasm. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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AIDS-related Kaposi's sarcoma is a clonal neoplasm.

Clin Cancer Res; 1(3):257-60 1995. Unique Identifier : AIDSLINE ICDB/95615095
Rabkin CS; Bedi G; Musaba E; Sunkutu R; Mwansa N; Sidransky D; Biggar RJ; Viral Epidemiology Branch, NCI, EPN/434, Bethesda, MD 20892

Abstract: Kaposi's sarcoma is generally believed to be a non-neoplastic hyperproliferation because it may regress spontaneously and its spindle cells lack features of typical tumor cells, such as aneuploidy, nuclear atypia, and permissive growth in cell culture. A fundamental characteristic of neoplasms is clonality, in that they arise from clonal replication of a single cell whereas reactive processes are derived from polyclonal proliferation. We used an X chromosome inactivation assay to determine the clonality of Kaposi's sarcoma nodules from patients with AIDS-related disease. The assay is based on a methyl-sensitive restriction digest followed by PCR amplification of the highly polymorphic androgen receptor gene. Two of three evaluable cases had a monoclonal pattern of inactivation, and the third case had a clonal expansion of cells with an altered microsatellite repeat sequence. These data suggest that Kaposi's sarcoma (at least in the AIDS setting) is a clonal neoplasm. (19 Refs)
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Aneuploidy Cell Division Dosage Compensation (Genetics) DNA, Satellite Human Polymerase Chain Reaction Polymorphism (Genetics) Receptors, Androgen/GENETICS Repetitive Sequences, Nucleic Acid Sarcoma, Kaposi's/GENETICS/*PATHOLOGY Tumor Cells, Cultured JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/KWDcomplicationsaneuploidycelldivisiondosagecompensation(genetics)dna,satellitehumanpolymerasechainreactionpolymorphism(genetics)receptors,androgen/geneticsrepetitivesequences,nucleicacidsarcoma,kaposi's/genetics/KWDpathologytumorcells,culturedjournalarticle
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M9570945

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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