Differences in the tissue-specific homing of alpha beta and gamma delta T cells to gut and peripheral lymph nodes.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Differences in the tissue-specific homing of alpha beta and gamma delta T cells to gut and peripheral lymph nodes.

Int Immunol. 1994 Dec;6(12):1891-7. Unique Identifier : AIDSLINE MED/95210206
Washington EA; Katerelos M; Cahill RN; Kimpton WG; Laboratory for Foetal and Neonatal Immunology, School of; Veterinary Science, University of Melbourne, Parkville, Victoria,; Australia.

Abstract: Tissue-selective streaming of T cells is considered to be a critical element in the integration of normal immune responses in intact animals. The results presented in this paper show that while there were major subsets of gut-homing T cells present in intestinal lymph, there were considerable differences in the tissue tropism of T cell populations circulating in lymph draining gut and peripheral lymph nodes. Thus, while CD4+ cells returned preferentially to their tissue of origin, gamma delta T cells showed a strong migratory preference for peripheral lymph nodes regardless of their tissue of origin. In contrast, although a population of gut-homing CD8+ cells was present in ileal lymph, CD8+ T cells from peripheral lymph nodes homed equally well to gut and lymph nodes. There were also considerable differences in the expression of L-selectin on T cells circulating in the two compartments. L-selectin was down-regulated on alpha beta T cells present in ileal lymph but not on gamma delta T cells which expressed the highest levels of L-selectin of all T cell subsets. It is suggested that gut-homing alpha beta T cells which have down-regulated L-selectin are formed in the gut-associated lymphoid tissues in response to gut antigens while the migratory properties of gamma delta T cells are ontogenetically determined, independent of antigen.

Keywords: Animal Cell Movement/IMMUNOLOGY CD4-Positive T-Lymphocytes/IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY Flow Cytometry Gastrointestinal System/*IMMUNOLOGY Lymph Nodes/*CYTOLOGY Receptors, Antigen, T-Cell, alpha-beta/*IMMUNOLOGY Receptors, Antigen, T-Cell, gamma-delta/*IMMUNOLOGY Sheep Support, Non-U.S. Gov't T-Lymphocyte Subsets/*IMMUNOLOGY JOURNAL ARTICLE
950730
M9570935

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