Prognostic value of interleukin-8 in AIDS-associated Pneumocystis carinii pneumonia. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Prognostic value of interleukin-8 in AIDS-associated Pneumocystis carinii pneumonia.

Am J Respir Crit Care Med. 1995 Apr;151(4):1058-62. Unique Identifier : AIDSLINE MED/95211316
Benfield TL; Vestbo J; Junge J; Nielsen TL; Jensen AB; Lundgren JD; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Denmark.

Abstract: Interleukin-8 (IL-8) is a potent neutrophil chemoattractant and activator. Pneumocystis carinii pneumonia is associated with an accumulation of neutrophils in bronchoalveolar lavage (BAL) fluid. Thus, we hypothesized that IL-8 is involved in the pathogenesis of P. carinii pneumonia. BAL fluid and serum were prospectively collected in 76 consecutive HIV-infected patients with a primary episode of P. carinii pneumonia, as well as in 10 healthy control subjects. Patients were found to have elevated levels of IL-8 in BAL fluid compared with control subjects (p < 0.01). Nine patients died during the course of P. carinii pneumonia. Comparing survivors with nonsurvivors, the median IL-8 level in BAL fluid was 127 (0 to 3,900) versus 584 (127 to 6,100) pg/ml (p < 0.05). Furthermore, patients with levels of IL-8 in BAL fluid greater than 90 pg/ml (i.e., greater than control subjects) had significantly worse vital prognosis (log rank test, p < 0.05). Thirteen percent required mechanical ventilation (MV). Patients requiring MV had a median IL-8 level of 396 (25 to 6,100) versus 129 (0 to 3,900) pg/ml for patients not requiring MV (p < 0.05). In conclusion: i) IL-8 in BAL fluid correlates to the clinical severity of the pneumonia, and ii) is a predictor of mortality and severe respiratory compromise.
Keywords: Adult AIDS-Related Opportunistic Infections/BLOOD/*METABOLISM/MORTALITY Biological Markers Bronchoalveolar Lavage Fluid/*CHEMISTRY Human Interleukin-8/*ANALYSIS/BLOOD Middle Age Pneumonia, Pneumocystis carinii/BLOOD/*METABOLISM/MORTALITY Prognosis Prospective Studies Support, Non-U.S. Gov't JOURNAL ARTICLEKWDadultaids-relatedopportunisticinfections/blood/KWDmetabolism/mortalitybiologicalmarkersbronchoalveolarlavagefluid/KWDchemistryhumaninterleukin-8/KWDanalysis/bloodmiddleagepneumonia,pneumocystiscarinii/blood/KWDmetabolism/mortalityprognosisprospectivestudiessupport,non-uKWDsKWDgov'tjournalarticle
950730
M9570918

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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