Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi's sarcoma. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi's sarcoma.

J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):455-60. Unique Identifier : AIDSLINE MED/95211537
Louie S; Cai J; Law R; Lin G; Lunardi-Iskandar Y; Jung B; Masood R; Gill P; Kenneth Norris Jr. Cancer Center, University of Southern; California, Los Angeles 90033, USA.

Abstract: Kaposi's sarcoma (KS) is the most common tumor seen in patients with HIV-1 infection. HIV-1 may induce KS directly through viral protein(s) or indirectly through regulation of cytokines such as IL-1 and IL-6. We have shown that AIDS-KS spindle cells express IL-1 beta and that IL-1ra inhibits KS-spindle cell growth. IL-1ra had little effect on human umbilical vein endothelial cells (HUVEC), human aortic smooth muscle cells (HASM), and human foreskin fibroblast (NN41). These findings support an autocrine activity for IL-1. Furthermore, exogenous IL-1 can enhance AIDS-KS cell growth, and this effect is completely blocked by IL-1ra. As expected, IL-1ra also blocks IL-1 mediated upregulation of IL-6 and bFGF, both of which are autocrine growth factors for KS. IL-1ra is thus a potential candidate for the treatment of AIDS-associated KS.
Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Blotting, Northern Cell Division/DRUG EFFECTS Cell Line Endothelium, Vascular/CYTOLOGY/DRUG EFFECTS Fibroblast Growth Factor, Basic/BIOSYNTHESIS Fibroblasts/CYTOLOGY/DRUG EFFECTS Gene Expression Regulation, Neoplastic Growth Inhibitors/BIOSYNTHESIS Human HIV-1 Interleukin-1/BIOSYNTHESIS/GENETICS/*PHARMACOLOGY Interleukin-6/BIOSYNTHESIS/GENETICS Muscle, Smooth, Vascular/CYTOLOGY/DRUG EFFECTS Peptides/BIOSYNTHESIS Receptors, Interleukin-1/*ANTAGONISTS & INHIB RNA, Messenger/BIOSYNTHESIS Sarcoma, Kaposi's/ETIOLOGY/IMMUNOLOGY/*PATHOLOGY Sialoglycoproteins/*PHARMACOLOGY Support, U.S. Gov't, P.H.S. Thymidine/METABOLISM Tumor Cells, Cultured JOURNAL ARTICLEKWDacquiredimmunodeficiencysyndrome/
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Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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