Complement activation and immune complexes in early congenital HIV infection. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Complement activation and immune complexes in early congenital HIV infection.

J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):480-5. Unique Identifier : AIDSLINE MED/95211541
Jarvis JN; Taylor H; Iobidze M; Division of Immunology/Rheumatology, Wayne State University; School of Medicine, Detroit, MI, USA.

Abstract: Previous reports from our laboratory have shown that complement activation and the presence of circulating immune complexes are features of congenital human immunodeficiency virus (HIV) infection as they are in HIV-infected adults. The studies reported here were undertaken to (a) define whether complement activation is congenitally infected infants and children involves classic, alternative, or both pathways; (b) investigate the relationship between complement activation and circulating immune complexes; and (c) determine how early in congenital HIV infection complement activation and immune complexes can be found. We report that classic complement pathway activation and C1q-binding immune complexes can be found within the first 4 months of congenital HIV infection. However, the association between classic pathway activation and immune complexes before age 10 months was weak. These data raise interesting questions about complement-mediated immune complex processing in HIV-infected infants and young children.
Keywords: Age Factors Antigen-Antibody Complex/*BLOOD/METABOLISM *Complement Activation Complement Pathway, Classical Complement 1q/METABOLISM Complement 4/ANALYSIS Human HIV Infections/*CONGENITAL/*IMMUNOLOGY Infant Infant, Newborn Peptide Fragments/ANALYSIS Support, Non-U.S. Gov't JOURNAL ARTICLEKWDagefactorsantigen-antibodycomplex/KWDblood/metabolismKWDcomplementactivationcomplementpathway,classicalcomplement1q/metabolismcomplement4/analysishumanhivinfections/KWDcongenital/KWDimmunologyinfantinfant,newbornpeptidefragments/analysissupport,non-uKWDsKWDgov'tjournalarticle
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M9570908

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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