Rates of mother-to-child transmission of HIV-1 in Africa, America, and Europe: results from 13 perinatal studies. The Working Group on Mother-To-Child Transmission of HIV.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Rates of mother-to-child transmission of HIV-1 in Africa, America, and Europe: results from 13 perinatal studies. The Working Group on Mother-To-Child Transmission of HIV.

J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):506-10. Unique Identifier : AIDSLINE MED/95211544

Abstract: The goal of this exercise was to provide estimates of the mother-to-child transmission rate (TR) of human immunodeficiency virus type 1 (HIV-1), calculated according to standardized methods. Prospective cohort studies in Africa (8), the Caribbean (1), Europe (3), and the U.S.A. (1) observed from birth children born to women known to be HIV infected at the time of delivery. TRs were calculated and compared by investigators during a meeting in Ghent (Belgium) in September 1993 according to agreed methodology. TRs were calculated following the direct and the indirect methods developed in 1992 by the Ghent Working Group. The direct method uses a classification of children born to HIV-seropositive mothers according to their probable HIV infection status at 15 months of age or before, if they die or are lost to follow-up. Minimum, intermediate, and maximum estimates of TR are computed depending on how children classified as indeterminate are counted. The indirect method is applied for studies with a comparison cohort of children born to HIV-seronegative mothers. TRs in developed countries ranged from 14 to 25% with the direct method (intermediate estimate). In the developing world, they ranged from 13 to 42% with the direct method, from 21 to 43% with the indirect method, and most of the studies reported a TR in the range of 25 to 30%. With use of a standardized methodology, the overall TR of HIV-1 tends to be higher in Africa than in Europe or the U.S.A.(ABSTRACT TRUNCATED AT 250 WORDS)

Keywords: Africa Caribbean Region Cohort Studies Developing Countries *Disease Transmission, Vertical Europe Female Follow-Up Studies Human HIV Infections/*TRANSMISSION *HIV-1 Infant Infant, Newborn Pregnancy Prospective Studies United States JOURNAL ARTICLE MULTICENTER STUDY
950730
M9570905

AEGiS is a 501(c)3, not-for-profit, tax-exempt, educational corporation. AEGiS is made possible through unrestricted funding from Boehringer Ingelheim, Bridgestone/Firestone Charitable Trust, Bristol-Myers Squibb Company, Elton John AIDS Foundation, Gill Foundation, the National Library of Medicine, Quest Diagnostics, Roche and Trimeris, and donations from users like you. Always watch for outdated information. This article first appeared in 1995. This material is designed to support, not replace, the relationship that exists between you and your doctor.

AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

Copyright ©1980, 1995. AEGiS. All materials appearing on AEGiS are protected by copyright as a collective work or compilation under U.S. copyright and other laws and are the property of AEGiS, or the party credited as the provider of the content. .