Selective decrease in human immunodeficiency virus type 1 (HIV-1)-induced alpha interferon production by peripheral blood mononuclear cells during HIV-1 infection.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Selective decrease in human immunodeficiency virus type 1 (HIV-1)-induced alpha interferon production by peripheral blood mononuclear cells during HIV-1 infection.

Clin Diagn Lab Immunol. 1995 Mar;2(2):138-42. Unique Identifier : AIDSLINE MED/95211624
Ferbas J; Navratil J; Logar A; Rinaldo C; Department of Infectious Diseases and Microbiology, University of; Pittsburgh Graduate School of Public Health, Pennsylvania.

Abstract: We previously reported that human immunodeficiency virus type 1 (HIV-1), herpes simplex virus (HSV), and Sendai virus induce higher levels of alpha interferon (IFN-alpha) in blood dendritic cells than in monocytes of healthy donors. In the present study, the levels of IFN-alpha induced by T-cell tropic (IIIb and RF) and monocytotropic (BaL) strains of HIV-1 and by HSV were significantly decreased in peripheral blood mononuclear cells (PBMCs) derived from subjects with asymptomatic and symptomatic HIV-1 infection. In contrast, Sendai virus, a paramyxovirus that induces proportionally more IFN-alpha in monocytes and B cells than do either HIV-1 or HSV, stimulated normal levels of IFN-alpha in PBMCs from the HIV-1-infected men. The IFN-alpha produced by PBMCs from the HIV-1-seropositive subjects was partially acid labile, whereas the IFN-alpha produced by PBMCs from the HIV-1-seronegative donors was acid stable. We hypothesize that there is a selective defect in IFN-alpha production by peripheral blood dendritic cells, whereas the host retains the IFN-alpha-producing capacity of monocytes and B lymphocytes. The loss of IFN-alpha production in response to HIV-1, herpesviruses, and possibly other pathogens could contribute to the progression of HIV-1 infection and to the development of AIDS.

Keywords: Cells, Cultured Cohort Studies Human HIV Infections/*BLOOD/MICROBIOLOGY *HIV-1 Interferon-alpha/*BIOSYNTHESIS/BLOOD Leukocytes, Mononuclear/*METABOLISM/*VIROLOGY Male Parainfluenza Virus Type 1 Simplexvirus Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/IMMUNOLOGY/MICROBIOLOGY JOURNAL ARTICLE
950730
M9570900

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