1995

AIDs prevention for laboratory professionals. [videorecording]
Mount Kisco, N.Y. : Guidance Associates, c1992 1 videocassette (69 min.) : sd., col. ; 1/2 in. + 1 guide (16 p.) (AIDS) Unique Identifier : AIDSLINE AV/9506807
Alpert LI
AIDS prevention for nursing professionals. [videorecording]
Mount Kisco, N.Y. : Guidance Associates, c1992 1 videocassette (65 min.) : sd., col. ; 1/2 in. + 1 guide (16 p.) (AIDs) Unique Identifier : AIDSLINE AV/9506806
Alpert LI
The:person with AIDS : infection control. [videorecording]
[Baltimore, Md.] : The Press, c1994 1 videocassette (20 min.) : sd., col. ; 1/2 in (Nursing home infection control series) Unique Identifier : AIDSLINE AV/9503484
Smith PW
(Producer) In this video the viewer will learn specific guidelines which must be used when working with the person with AIDS in reference to blood-borne pathogens and other potentially infectious body fluids, universal precautions as applied to the nursing home environment and the personal and environmental safeguard


Ethical and social aspects of AIDS in Africa.
[London?] : Commonwealth Secretariat, [1990?] 55 p Unique Identifier : AIDSLINE CAT/9507361
Hausermann J
Treatment review.
New York, NY : AIDS Treatment Data Network, v Unique Identifier : AIDSLINE CAT/9507417
[AIDS-Szekcio.]
[Budapest] : A Tarsasag, 1991 76 p. : ill Unique Identifier : AIDSLINE CAT/9414745
Biologisen laaketieteen suuntauksia II : vapaiden radikaalien, ravinnon hivenaineiden, vitamiinien ja antioksidanttien merkitys ihmisen terveydelle : esitelmalyhennelmat.
Helsinki : Yliopistopaino, 1991 64 p. : ill Unique Identifier : AIDSLINE CAT/9405654
[La:lutte contre le SIDA en France.]
Paris : La Documentation francaise, c1992 108 p Unique Identifier : AIDSLINE CAT/9408830
Evin C
Compliance with CDC guidelines to prevent occupational transmission of human immunodeficiency virus and hepatitis B virus : evaluation findings from a national survey of health care workers : (final report).
Atlanta, Ga. : Centers for Disease Control, National Institute of Occupational Safety and Health, [1992] 1 v. (various pagings) Unique Identifier : AIDSLINE CAT/9507219
Hersey JC
[Eizu kiki : NHK supesharu.]
Tokyo : Nihon Hoso Shuppan Kyokai, 1992 213 p. : ill Unique Identifier : AIDSLINE CAT/9411213
[Je lust en je leven : een inventariserend onderzoek naar relatievorming, sexueel gedrag en de preventie van Aids op Curacao.]
Curacao : Nationale Aidscommissie van de Nederlandse Antillen, 1992 94 leaves Unique Identifier : AIDSLINE CAT/9433986
Alberts T
An:overview of HIV infections and AIDS. 4th ed.
La Mesa, CA : Western Schools Press, c1993 i, 112 p. : ill Unique Identifier : AIDSLINE CAT/9502897
Lamke C
Information for physicians on managing patients with HIV infection and AIDS.
[Victoria, B.C.] : BC Ministry of Health and Ministry Responsible for Seniors, [1993] 69 p (New directions in health) Unique Identifier : AIDSLINE CAT/9504282
Barron SR
One boy at war : my life in the AIDS underground. 1st ed.
New York : A.A. Knopf ; Distributed by Random House, 1993 xxiii, 387 p Unique Identifier : AIDSLINE CAT/9503831
Sergios PA
Counselling guidelines for human immunodeficiency virus serologic testing.
Ottawa : Canadian Medical Association, c1993 17 p Unique Identifier : AIDSLINE CAT/9503440
Chateauvert M
The:experimental treatment guide. Fall 1993-
New York, NY : AIDS Treatment Data Network, [1993- v Unique Identifier : AIDSLINE CAT/9438461
Trends and patterns of HIV/AIDS infection in selected developing countries : country profiles, December 1993.
Washington, DC : Health Studies Branch, Center for International Research, U.S. Bureau of the Census, [1993] 1 v. (unpaged) : ill (Research note ; no. 12) Unique Identifier : AIDSLINE CAT/9508024
Ethics in an epidemic : AIDS, morality, and culture.
Berkeley : University of California Press, c1994 vii, 221 p. : ill Unique Identifier : AIDSLINE CAT/9503501
Murphy TF
Euthanasia and assisted suicide in persons with acquired immunodeficiency syndrome (AIDS) or human immunodeficiency virus (HIV).
New Wesminster, B.C. : Peroglyphics Pub., [1994] vi, 136 p Unique Identifier : AIDSLINE CAT/9503056
Ogden RD
[HIV-Ubertragung von der infizierten Mutter auf ihr Kind : Resultate der gesamtschweizerischen Neonatalen HIV-Studie : eine Arbeit aus der Padiatrischen AIDS-Gruppe Schweiz (PAGS) mit Unterstutzung des Bundesamts fur Gesundheitswesen und der Schweizerischen Neonatologiegruppe.]
Bern ; Seattle : Huber, c1994 x, 161 p. : ill Unique Identifier : AIDSLINE CAT/9501950
Kind C
Pediatric human immunodeficiency virus (HIV) infection : a compendium of AAP guidelines on pediatric HIV infection : a compilation of AAP policy statements and excerpts from manuals published through August 1994. Rev.
Elk Grove Village, IL : American Academy of Pediatrics, c1994 73 p Unique Identifier : AIDSLINE CAT/9443319
[Populations africaines et SIDA.]
Paris : Editions la decouverte, c1994 223 p. : ill (Collections Recherches) Unique Identifier : AIDSLINE CAT/9503279
Auvert B
Posters in AIDS education : produced by governmental and non-governmental organisations in Africa, Australia, Asia, Europe, Latin America, and North America.
Health Dept. Wuerzburg, Germany : The Department, [1994?] 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9505738
[SIDA : et pratique medicale quotidienne : approche clinique, sociale et therapeutique.]
Paris : Frison-Roche, c1994 200 p. : ill Unique Identifier : AIDSLINE CAT/9505612
Force G
[24. Hamophilie-Symposion : Hamburg 1993.]
Berlin ; New York : Springer-Verlag, c1994 xxxvii, 440 p. : ill Unique Identifier : AIDSLINE CAT/9501060
The:AIDS manual : a comprehensive reference on the human immunodeficiency virus (HIV). 3rd ed.
Sydney ; Philadelphia : MacLennan + Petty, 1994 xvii, 262 p. : ill Unique Identifier : AIDSLINE CAT/9507667
WHO/UNESCO pilot projects on school-based AIDS education : a summary.
[Geneva] : World Health Organization, 1994 55 p Unique Identifier : AIDSLINE CAT/9504331
Good doctors, good patients : partners in HIV treatment.
New York : NCM Publishers, 1994 x, 201 p. : ports Unique Identifier : AIDSLINE CAT/9505596
Rabkin JG; Remien RH; Wilson CR
Recent HIV seroprevalence levels by country : June 1994.
[Washington, D.C.] : Health Studies Branch, Center for International Research, U.S. Bureau of the Census, [1994] v, 45 p. : ill (Research note ; no. 13) Unique Identifier : AIDSLINE CAT/9505760
Corbin J
Sexual behaviour and AIDS.
Aldershot ; Brookfield, USA : Avebury, c1994 xvii, 324 p. : ill Unique Identifier : AIDSLINE CAT/9505720
Spira A; Bajos N
Trends and patterns of HIV/AIDS infection in selected developing countries : country profiles, June 1994.
Washington, DC : Health Studies Branch, Center for International Research, U.S. Bureau of the Census, [1994] 1 v. (unpaged) : ill (Research note ; no. 14) Unique Identifier : AIDSLINE CAT/9505761
Corbin J
AIDS and the arrows of pestilence.
Golden, Colo. : Fulcrum Pub., c1994 xvii, 171 p. : ill Unique Identifier : AIDSLINE CAT/9502874
Clark CF
[HIV und AIDS im Spiegel der Wissenschaft : Vortrage im Rahmen einer interdisziplinaren Ringvorlesung.]
Angelegenheiten St. Ingbert : Rohrig Universitatsverlag, 1994 205 p. : ill (Saarbrucker Hochschulschriften ; Bd. 23) Unique Identifier : AIDSLINE CAT/9504301
You don't have to die : unraveling the AIDS myth.
Puyallup, Wash. : Future Medicine Pub., c1994 xiv, 319 p. : ill Unique Identifier : AIDSLINE CAT/9502561
Chaitow L; Strohecker J
Technical advances in AIDS research in the human nervous system.
New York : Plenum Press, c1995 ix, 373 p. : ill., port Unique Identifier : AIDSLINE CAT/9507377
Major EO; Levy JA; Nervous System
The:bloodborne pathogens standard : a pragmatic approach.
New York : Van Nostrand Reinhold, 1995 Unique Identifier : AIDSLINE CAT/9507650
O'Neal JT
The:molecular biology of HIV/AIDS.
Chichester ; New York : J. Wiley & Sons, c1996 viii, 222 p. : ill (Molecular medical science series) Unique Identifier : AIDSLINE CAT/9507915
Lever AM
Infection control in the immunocompromised host.
Berlin ; Boston : Blackwell Wissenschafts-Verlag, 1995 156 p. : ill (Ex Libris, Roche v. 2) Unique Identifier : AIDSLINE CAT/9506023
Schrappe M; Seifert H; Immunocompromised Host
Results of chemoradiation for epidermoid carcinoma of the anorectum in 42 patients (Meeting abstract).
International Congress of Radiation Oncology 1993. June 21-25, 1993, Kyoto, Japan, p. 258, 1993.. Unique Identifier : AIDSLINE ICDB/95605961
Rao A; Smith D; Shah K; Neville C; Frost D; Latino F; Dept. of Radiation Oncology, Kaiser Permanente Medical Center,; 4950 Sunset Blvd., Los Angeles, CA 90027
Chemoradiation for epidermoid carcinoma of the anorectum is well established. The medical records of 42 patients diagnosed with anal cancer treated under protocol between 1987 and 1991 were reviewed. Patients received 5-FU and mitomycin C concurrent with radiation of 30 Gy over 3 weeks to the pelvis followed by 5-FU.


Innovative treatments for Kaposi's sarcoma (Meeting abstract).
Melanoma Res; 3:8 1993. Unique Identifier : AIDSLINE ICDB/95607236
Conant MA; University of California Medical Center, San Francisco, CA
New approaches in the management of Kaposi s sarcoma (KS) have been developed in the past three years, including new delivery mechanisms, autologous CD-8 expansion and cytokine development. At the Berlin AIDS Conference it was shown that 5-FU in an implant containing collagen and epinephrine was safe. The response to


Immunologic and immunogenetic findings in patients affected by classic Kaposi's sarcoma in Sardinia (Meeting abstract).
Melanoma Res; 3:14 1993. Unique Identifier : AIDSLINE ICDB/95607242
Cerimele D; Contu L; Cottoni F; Carcassi C; Dept. of Dermatology, Catholic University, Rome
106 patients affected by the classic type of Kaposi s sarcoma all born and living in North-East Sardinia have been studied. In 70 patients the disease was circumscribed and in 36 it was disseminated. Reduced number of CD4+ and increased number of CD8+ T-lymphocytes was observed; CD4:CD8 ratio was 1.40 +/- 0.5 in the p


Lowered minimal erythema dose (med) at 297 nm UVB but not at 360 nm UVA under recombinant interferon alpha (Meeting abstract).
Melanoma Res; 3:21 1993. Unique Identifier : AIDSLINE ICDB/95607257
Hohenbleicher H; Gollnick HP; Department of Dermatology, University Medical Center Steglitz,; The Free University of Berlin, Berlin, Germany
Recombinant alpha-interferon, a biological immune response modifier, is an established therapeutic agent for benign and malignant diseases. In dermatology it is intensively used for cutaneous T-cell lymphomas (CTCL), malignant melanoma (MM) and Kaposi s sarcoma (KS) in HIV-infection either alone or in combination with


Neuro-Oncology. Primary tumors and neurological complications of cancer.
Neuro-Oncology: Primary Tumors and Neurological Complications of Cancer. Twijnstra A, Keiser A, Ongerboer De Visser BW, eds. Amsterdam, The Netherlands, Elsevier, 487 p., 1993.. Unique Identifier : AIDSLINE ICDB/95615463
Anonymous; No affiliation given
This book is intended to provide an overview of the management of patients suffering from primary tumors of the nervous system and from the metastatic and nonmetastatic neurological complications of systemic cancer, and to assist physicians dealing with those problems. An international roster of 33 contributing author


Antisense research and applications.
Antisense Research and Applications. Crooke ST, Lebleu B, eds. Boca Raton, FL, CRC Press, 579 p., 1993.. Unique Identifier : AIDSLINE ICDB/95615469
Anonymous; No affiliation given
It has only recently become accepted that oligonucleotides might have therapeutic utility. Although new to human therapeutics, small, diffusible, untranslated RNA transcripts, termed antisense RNAs, that pair to specific target RNAs at regions of complementarity, occur universally among prokaryotes and eukaryotes, ser


Interleukin-6 (IL-6) and AIDS-Kaposi's sarcoma: a nested case-control study within the multicenter aids cohort study (MACS).
Diss Abstr Int [B]; 55(3):843 1994. Unique Identifier : AIDSLINE ICDB/95607535
Dourado MIC; Univ. of California, Los Angeles
Since the beginning of the AIDS epidemic, a large research activity has focused on the etiology of Kaposi s sarcoma (KS) among HIV infected individuals. There are several hypothesized risk factors for AIDS-KS. However, there is not enough evidence supporting the existing hypotheses. Recently, a number of studies have


AIDS-related Kaposi's sarcoma is a clonal neoplasm.
Clin Cancer Res; 1(3):257-60 1995. Unique Identifier : AIDSLINE ICDB/95615095
Rabkin CS; Bedi G; Musaba E; Sunkutu R; Mwansa N; Sidransky D; Biggar RJ; Viral Epidemiology Branch, NCI, EPN/434, Bethesda, MD 20892
Kaposi s sarcoma is generally believed to be a non-neoplastic hyperproliferation because it may regress spontaneously and its spindle cells lack features of typical tumor cells, such as aneuploidy, nuclear atypia, and permissive growth in cell culture. A fundamental characteristic of neoplasms is clonality, in that th


[Renewed occurrence of Mycoplasma (editorial)]
Duodecim. 1992;108(12):1092-4. Unique Identifier : AIDSLINE MED/95212213
Hakkarainen K; Miettinen A; Turunen H; Luotola K; Karppelin M; Kaitila K; Jansson E
[Hepatitis C viral infection and the consumption of intravenous drugs]
Rev Sanid Hig Publica (Madr). 1992 May-Aug;66(3-4):233-7. Unique Identifier : AIDSLINE MED/95242030
Payeras Cifre A; Socias Moya M; Forteza-Rei Borralleras J; Besalduch Vidal J; Servicio de Medicina Interna, Hospital Son Dureta, Palma de; Mallorca, Baleares.
BACKGROUND: To know the antibodies seroprevalence against hepatitis C virus (HCV), as well as other factors associated to these antibodies presence in a group of intravenous drug users (IVDU) in Baleares. To know what screening test would be the most adequate to detect antibodies against HCV in this group. METHODS: Th


[The spread of human immunodeficiency virus infection (HIV-1/HIV-2) and of hepatitis B and C in non-drug-addicted prostitutes. Extremadura]
Rev Sanid Hig Publica (Madr). 1992 Sep-Dec;66(5-6):265-71. Unique Identifier : AIDSLINE MED/95242035
Gimeno Ortiz A; Jimenez Romano R; Vazquez Domingez JA; Gomez Martinez MC; Muniz Perez E; Servicio de Medicina Preventiva y Salud Publica, Facultad de; Medicina, Universidad de Extremadura.
BACKGROUND: The proportion of cases of AIDS in Extremadura, in which sexual transmission has existed, is comparatively lower than the national one. The possibilities of the infection introduction in the general population may increase the relative importance of this way of transmission in the future. Penetration of HI


[HIV infections and tuberculosis in Haiti]
Bol Oficina Sanit Panam. 1995 Feb;118(2):161-9. Unique Identifier : AIDSLINE MED/95209760
Hyppolite PR; Pape JW; Grupo Haitiano de Estudio del Sarcoma de Kaposi y la Infeccion; Oportunista, Puerto Principe, Haiti.
Gastric localization of Leishmania in a patient with acquired immunodeficiency syndrome. A case report.
APMIS. 1995 Jan;103(1):25-8. Unique Identifier : AIDSLINE MED/95209847
Gradoni L; Guaraldi G; Codeluppi M; Scalone A; Rivasi F; Laboratory of Parasitology, Istituto Superiore di Sanita, Rome,; Italy.
We report a case of gastric localization of Leishmania in a 29-year old man affected by AIDS. Gastric biopsies revealed macrophages infected with intracytoplasmic organisms attributable to Leishmania amastigotes. The authors emphasize the importance of performing random biopsies in the absence of endoscopic abnormalit


[The acquired immunodeficiency syndrome, hypertrophic myocardiopathy and multivalvular infectious endocarditis. Apropos a clinical case]
Rev Port Cardiol. 1995 Jan;14(1):53-8. Unique Identifier : AIDSLINE MED/95209917
Jaques AK; Arroja I; Araujo C; Azevedo J; Borges A; Santos I; Cabral A; Campos MJ; Mansinho K; Borges F; et al; Laboratorio de Ecocardiografia, Hospital Egas Moniz, Lisboa.
We present a clinical case of a 33 years old young male, gypsy, intravenous drug abuser with heroine and cocaine and AIDS diagnosis. The clinical anamnesis was mainly fever and systolic heart murmur in a clinical scenario of AIDS. The two-dimensional echocardiographic study was clearly diagnostic of an hypertrophic ob


Hospice education about people with AIDS as terminally ill patients: coping with a new epidemic of death.
Am J Hosp Palliat Care. 1995 Jan-Feb;12(1):25-31. Unique Identifier : AIDSLINE MED/95209982
Dukes CS; Turpin BA; Atwood JR
Hospice care for patients with AIDS often differs from care provided to patients with other terminal illnesses, such as cancer. We designed a seminar series to educate regional hospice staff about these differences and subsequently determined if the educational intervention was associated with improvements in their AI


Stressors of hospice home care nurses caring for AIDS patients: a pilot study.
Am J Hosp Palliat Care. 1995 Jan-Feb;12(1):32-6. Unique Identifier : AIDSLINE MED/95209984
Slone M; Stephany T
This exploratory study identified stressors of home care hospice nurses caring for hospice patients with AIDS. Five hospice home care nurses provided data obtained from demographic questionnaires and semistructured interviews. Results of this pilot study confirmed that experienced hospice nurses believe there is a dif


Gay and bisexual male domestic violence victimization: challenges to feminist theory and responses to violence.
Violence Vict. 1994 Summer;9(2):95-106. Unique Identifier : AIDSLINE MED/95210185
Letellier P; Family Violence Project, District Attorney's Office, San; Francisco.
This article demonstrates how same-sex male battering challenges contemporary feminist domestic violence theory. The author shows current theory to be heterosexist and therefore insufficient to explain the phenomenon of battering among gay/bisexual men. Domestic violence theories that integrate a sociopolitical and a


Differences in the tissue-specific homing of alpha beta and gamma delta T cells to gut and peripheral lymph nodes.
Int Immunol. 1994 Dec;6(12):1891-7. Unique Identifier : AIDSLINE MED/95210206
Washington EA; Katerelos M; Cahill RN; Kimpton WG; Laboratory for Foetal and Neonatal Immunology, School of; Veterinary Science, University of Melbourne, Parkville, Victoria,; Australia.
Tissue-selective streaming of T cells is considered to be a critical element in the integration of normal immune responses in intact animals. The results presented in this paper show that while there were major subsets of gut-homing T cells present in intestinal lymph, there were considerable differences in the tissue


An IFN-gamma-dependent pathway plays a critical role in the pathogenesis of murine immunodeficiency syndrome induced by LP-BM5 murine leukemia virus.
Int Immunol. 1994 Dec;6(12):1937-47. Unique Identifier : AIDSLINE MED/95210211
Uehara S; Hitoshi Y; Numata F; Makino M; Howard M; Mizuochi T; Takatsu K; Department of Immunology, University of Tokyo, Japan.
The murine acquired immunodeficiency syndrome (MAIDS) caused by a defective murine leukemia virus produces severe immunodeficiency with abnormal lymphoproliferation and hypergammaglobulinemia. The presence of both CD4+ T cells and B cells is critical for the development of this disease. Remarkably elevated mRNA expres


Dynamic changes of accumulated T cell clonotypes during antigenic stimulation in vivo and in vitro.
Int Immunol. 1994 Dec;6(12):1959-66. Unique Identifier : AIDSLINE MED/95210213
Masuko K; Kato T; Ikeda Y; Okubo M; Mizushima Y; Nishioka K; Yamamoto K; Division of Rheumatology and Molecular Immunology, St Marianna; University, Kanagawa, Japan.
It has not been known how T cell clones respond to antigenic stimulation. We applied reverse transcription polymerase chain reaction and subsequent single-strand conformation polymorphism (SSCP) analysis to monitor the kinetics of accumulated T cell clonotypes with respect to the TCR beta chain. Before exposure to an


Retinal detachments in patients with AIDS and CMV retinopathy: a role for laser photocoagulation.
Br J Ophthalmol. 1995 Feb;79(2):153-6. Unique Identifier : AIDSLINE MED/95210236
McCluskey P; Grigg J; Playfair TJ; Laboratory of Ocular Immunology, School of Pathology, University; of New South Wales, Australia.
A retrospective review of all patients with a cytomegalovirus ( CMV ) related retinal detachment and HIV infection managed at the ocular immunology clinic at St Vincent s Hospital between January 1985 and June 1992 was performe


Pharmacokinetic variability in the adolescent: implications of body size and organ function for dosage regimen design.
J Adolesc Health. 1994 Dec;15(8):654-62. Unique Identifier : AIDSLINE MED/95210289
Rodman JH; Pharmaceutical Department, St. Jude Children's Research Hospital,; Memphis, Tennessee 38105.
Although there are convincing clinical studies demonstrating important pharmacokinetic differences between the adult and pediatric patient, guidelines for adjusting the dosages of specific drugs are often based on empirical and limited data. Adult doses often provide the reference point for therapy in children with ad


[Current status of HIV epidemic and prevention and control program in Cambodia]
Nippon Koshu Eisei Zasshi. 1995 Jan;42(1):44-9. Unique Identifier : AIDSLINE MED/95210697
Kihara M; Tajima K; Tomizawa I; Ozaki S; Soda K
[Current status of HIV/AIDS epidemic and anti-AIDS campaign in Thailand]
Nippon Koshu Eisei Zasshi. 1995 Jan;42(1):50-5. Unique Identifier : AIDSLINE MED/95210698
Rojanapithayakorn W; Department of Communicable Disease Control, Ministry of Public; Health, Thailand.
Surveillance systems for communicable diseases in Denmark.
Int J Med Microbiol Virol Parasitol Infect Dis. 1994 Oct;281(3):276-83. Unique Identifier : AIDSLINE MED/95210787
Pedersen NS; Smith E; Department of Epidemiology, Statens Seruminstitut, Copenhagen,; Denmark.
Actual epidemiological problems of bloodborne diseases.
Int J Med Microbiol Virol Parasitol Infect Dis. 1994 Oct;281(3):313-6. Unique Identifier : AIDSLINE MED/95210791
Magdzik W; National Institute of Hygiene, Department of Epidemiology,; Warsaw, Poland.
Characterization of HIV infection and seroconversion by a stochastic model of the HIV epidemic.
Math Biosci. 1995 Mar;126(1):81-123. Unique Identifier : AIDSLINE MED/95210860
Tan WY; Lee SR; Tang SC; Department of Mathematical Sciences, University of Memphis,; Tennessee.
In this paper we use a stochastic model for the HIV epidemic in homosexual populations to characterize the HIV infection and seroconversion. Using computer generated data, we compare the fitting of infection distributions and of seroconversion distributions by different parametric models as well as by nonparametric me


Diagnostic imaging in the evaluation of renal lymphoma.
Leuk Lymphoma. 1994 Dec;16(1-2):37-50. Unique Identifier : AIDSLINE MED/95210983
Eisenberg PJ; Papanicolaou N; Lee MJ; Yoder IC; Department of Radiology, Massachusetts General Hospital and; Harvard Medical School, Boston, MA 02114.
Renal lymphoma usually is a manifestation of disseminated disease and often is asymptomatic. Occasionally, the kidney(s) may be the major or only demonstrable site of disease, which may then present with a variety of urologic symptoms. The imaging studies should be tailored according to the presenting symptoms and pri


Awareness of AIDS among doctors in Jaipur [letter]
Natl Med J India. 1995 Jan-Feb;8(1):46. Unique Identifier : AIDSLINE MED/95211005
Maheshwari VD; Sharma R; Gupta R; Sharma GL; Sharma SK
Mycobacterial infections in patients with AIDS in a low HIV prevalence area.
Cent Eur J Public Health. 1994 Dec;2(2):100-2. Unique Identifier : AIDSLINE MED/95211081
Stankova M; Rozsypal H; Kubin M; Slosarek M; Horova B; Bruckova M; Infection Clinic, 3rd Medical Faculty, Charles University,; Prague, Czech Republic.
The Czech Republic is characterized here as both a low HIV prevalence area (1.64 registered positivity per 10(5) population and 45 AIDS patients notified in the 1986-93 period) and a low tuberculosis prevalence area (mortality rate 0.8, incidence of bacillary pulmonary cases


Chemical synthesis of the aspartic proteinase from human immunodeficiency virus (HIV).
Methods Mol Biol. 1994;36:287-304. Unique Identifier : AIDSLINE MED/95211188
Hoeprich PD Jr; Applied Biosystems Inc., Foster City, CA.
Sorrow and strength--AIDS quilt news. Making the quilt with hearts and hands [news]
Aust Nurs J. 1994 Feb;1(7):29. Unique Identifier : AIDSLINE MED/95211248
Brunt L
Sorrow and strength--AIDS Quilt news [news]
Aust Nurs J. 1994 Feb;1(7):29. Unique Identifier : AIDSLINE MED/95211249
Fabb L
Do we need infection police? [editorial]
Aust Nurs J. 1994 Feb;1(7):3. Unique Identifier : AIDSLINE MED/95211250
Tattam A
Prognostic value of interleukin-8 in AIDS-associated Pneumocystis carinii pneumonia.
Am J Respir Crit Care Med. 1995 Apr;151(4):1058-62. Unique Identifier : AIDSLINE MED/95211316
Benfield TL; Vestbo J; Junge J; Nielsen TL; Jensen AB; Lundgren JD; Department of Infectious Diseases, Hvidovre Hospital, University; of Copenhagen, Denmark.
Interleukin-8 (IL-8) is a potent neutrophil chemoattractant and activator. Pneumocystis carinii pneumonia is associated with an accumulation of neutrophils in bronchoalveolar lavage (BAL) fluid. Thus, we hypothesized that IL-8 is involved in the pathogenesis of P. carinii pneumonia. BAL fluid and serum were prospectiv


Pentamidine aerosol versus trimethoprim-sulfamethoxazole for Pneumocystis carinii in acquired immune deficiency syndrome.
Am J Respir Crit Care Med. 1995 Apr;151(4):1068-74. Unique Identifier : AIDSLINE MED/95211318
Montgomery AB; Feigal DW Jr; Sattler F; Mason GR; Catanzaro A; Edison R; Markowitz N; Johnson E; Ogawa S; Rovzar M; et al; Medical Service, San Francisco General Hospital.
Pneumocystis carinii pneumonia remains one of the most common opportunistic infections in patients with acquired immune deficiency syndrome (AIDS). Treatment with either intravenous pentamidine or trimethoprim-sulfamethoxazole (TMP-SMX) is frequently complicated by serious adverse reactions. This study was a prospecti


The person from Porlock. Ethical issues in terminal care: the Dutch perspective [see comments]
Support Care Cancer. 1995 Jan;3(1):61-5. Unique Identifier : AIDSLINE MED/95211392
Blijham GH; Department of Internal Medicine, University Hospital Utrecht, The; Netherlands.
In the Netherlands medical decisions concerning end of life (MDEL) play a role in 38% of all deaths. Euthanasia, defined as an intentional termination of life by somebody else at an individual s request, is done in 1.8% of deaths. Only 4% of Dutch physicians would never perfor


Induction by human immunodeficiency viruses types 1 and 2 of degradation of CD4 but not of a CD4 mutant unable to bind viral envelope glycoproteins.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):427-36. Unique Identifier : AIDSLINE MED/95211534
Cucchiarini M; Cagnon L; Giordanengo V; Doglio A; Lefebvre JC; Laboratoire de Virologie, Faculte de Medecine, Nice, France.
HIV-1 appears to use a multiple gene strategy to regulate CD4 receptor expression, which emphasizes the importance of this regulation in the viral life cycle. The cytoplasmic interaction between gp160 and CD4 is probably the major event governing CD4 down-regulation, although other viral proteins, such as Nef (CD4 cel


HIV-1 infection of human brain-derived microvascular endothelial cells in vitro.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):437-45. Unique Identifier : AIDSLINE MED/95211535
Poland SD; Rice GP; Dekaban GA; Department of Microbiology and Immunology, University of Western; Ontario, Canada.
We examined the ability of human immunodeficiency virus (HIV) type 1 (HIV-1) to infect in vitro, primary brain-derived human microvascular endothelial cells (HMEC) that constitute the blood-brain barrier (BBB). Immunofluorescence (IFA) and antigen capture assays failed to demonstrate p24 antigen from HIV inoculated en


Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification assay.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):446-54. Unique Identifier : AIDSLINE MED/95211536
Pachl C; Todd JA; Kern DG; Sheridan PJ; Fong SJ; Stempien M; Hoo B; Besemer D; Yeghiazarian T; Irvine B; et al; Nucleic Acid Systems, Chiron Corporation, Emeryville, California; 94608, USA.
The level of human immunodeficiency virus type 1 (HIV-1) RNA in human plasma has been quantitated directly with use of a solid-phase nucleic acid hybridization assay, based on branched DNA (bDNA) signal amplification technology with chemiluminescent detection. Signal amplification is accomplished by the incorporation


Effects of interleukin-1 and interleukin-1 receptor antagonist in AIDS-Kaposi's sarcoma.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):455-60. Unique Identifier : AIDSLINE MED/95211537
Louie S; Cai J; Law R; Lin G; Lunardi-Iskandar Y; Jung B; Masood R; Gill P; Kenneth Norris Jr. Cancer Center, University of Southern; California, Los Angeles 90033, USA.
Kaposi s sarcoma (KS) is the most common tumor seen in patients with HIV-1 infection. HIV-1 may induce KS directly through viral protein(s) or indirectly through regulation of cytokines such as IL-1 and IL-6. We have shown that AIDS-KS spindle cells express IL-1 beta and that IL-1ra inhibits KS-spindle cell growth. IL


Listeria monocytogenes infection and serotype distribution among HIV-infected persons in Los Angeles County, 1985-1992.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):461-5. Unique Identifier : AIDSLINE MED/95211538
Ewert DP; Lieb L; Hayes PS; Reeves MW; Mascola L; Acute Communicable Disease Control Unit, Los Angeles County; Department of Health Services, USA.
Persons infected with human immunodeficiency virus (HIV) are at greater risk of infection with Listeria monocytogenes (LM) than the general population. We quantify the risk of listeriosis in persons with acquired immune deficiency syndrome (AIDS) and HIV infection in Los Angeles County (LAC) and report the LM serotype


Clinical spectrum of HTLV-I in south Florida.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):466-73. Unique Identifier : AIDSLINE MED/95211539
Harrington WJ Jr; Ucar A; Gill P; Snodgrass S; Sheremata W; Cabral L; Rabin M; Byrne GE Jr; Berger J; Voight W; et al; Department of Medicine, FL 33136, USA.
A total of 113 patients with infection due to human T-cell leukemia virus type 1 (HTLV-I) were evaluated at the University of Miami from January 1988 to March 1993. Forty patients were identified with adult T-cell leukemia/lymphoma (ATLL) and 63 with HTLV-I-associated myelopathy (HAM). Three had concomitant ATLL and H


Use of the Markov model to estimate the waiting times in a modified WHO staging system for HIV infection.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):474-9. Unique Identifier : AIDSLINE MED/95211540
Schechter MT; Le N; Craib KJ; Le TN; O'Shaughnessy MV; Montaner JS; B.C. Centre for Excellence in HIV/AIDS, St. Paul's Hospital,; Vancouver, Canada.
Seroconverting men in the Vancouver Lymphadenopathy--Acquired Immune Deficiency Syndrome Study cohort were studied in this analysis to estimate the waiting times in the different stages of the modified World Health Organization (WHO) staging system for human immunodeficiency virus infe


Complement activation and immune complexes in early congenital HIV infection.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):480-5. Unique Identifier : AIDSLINE MED/95211541
Jarvis JN; Taylor H; Iobidze M; Division of Immunology/Rheumatology, Wayne State University; School of Medicine, Detroit, MI, USA.
Previous reports from our laboratory have shown that complement activation and the presence of circulating immune complexes are features of congenital human immunodeficiency virus (HIV) infection as they are in HIV-infected adults. The studies reported here were undertaken to (a) define whether complement activation i


HIV infection in women: an observational study of clinical characteristics, disease progression, and survival for a cohort of women in Chicago.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):486-95. Unique Identifier : AIDSLINE MED/95211542
Sha BE; Benson CA; Pottage JC Jr; Urbanski PA; Daugherty SR; Kessler HA; Department of Medicine, Rush Medical; College/Rush-Presbyterian-St. Luke's Medical Center, Chicago,; Illinois 60612, USA.
To further characterize the natural history of HIV infection in women in the antiretroviral era, we performed a longitudinal, descriptive analysis of demographic features, clinical characteristics, patterns of antiretroviral and prophylactic therapy, disease progression, and survival in a cohort of women followed at a


Long-term survivors with HIV-1 infection: incubation period and longitudinal patterns of CD4+ lymphocytes.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):496-505. Unique Identifier : AIDSLINE MED/95211543
Munoz A; Kirby AJ; He YD; Margolick JB; Visscher BR; Rinaldo CR; Kaslow RA; Phair JP; Department of Epidemiology, Johns Hopkins School of Public; Health, Baltimore, Maryland 21205, USA.
To characterize long-term survival with HIV-1, we need to estimate the proportion of seroconverters remaining free from clinical AIDS for long periods. We predict that approximately 13% of homosexual/bisexual men infected at a young age may remain so for > 20 years. Since studies have not followed individuals for such


Rates of mother-to-child transmission of HIV-1 in Africa, America, and Europe: results from 13 perinatal studies. The Working Group on Mother-To-Child Transmission of HIV.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):506-10. Unique Identifier : AIDSLINE MED/95211544
The goal of this exercise was to provide estimates of the mother-to-child transmission rate (TR) of human immunodeficiency virus type 1 (HIV-1), calculated according to standardized methods. Prospective cohort studies in Africa (8), the Caribbean (1), Europe (3), and the U.S.A. (1) observed from birth children born to


HTLV-I infection among prostitutes and pregnant women in Kinshasa, Zaire: how important is high-risk sexual behavior?
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):511-5. Unique Identifier : AIDSLINE MED/95211545
Delaporte E; Buve A; Nzila N; Goeman J; Dazza MC; Henzel D; Heyward W; St-Louis M; Piot P; Laga M; Institute of Tropical Medicine, Antwerp, Belgium.
High-risk sexual behavior as risk factor for human T-cell lymphotropic virus type I (HTLV-I) infection was assessed in cross-sectional studies with 1,183 prostitutes and 1,166 pregnant women in Kinshasa, Zaire . Eighty six (7.3%) prostitutes were positive for HTLV-I. The seropreval


Identification of IIa and IIb molecular subtypes of human T-cell lymphotropic virus type II among Italian injecting drug users.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Apr 15;8(5):516-20. Unique Identifier : AIDSLINE GENBANK/X80244
Salemi M; Cattaneo E; Casoli C; Bertazzoni U; Istituto di Genetica Biochimica ed Evoluzionistica, CNR, Pavia,; Italy.
The molecular characterization of two human T-cell lymphotropic virus type II (HTLV-II) isolates, Gu and Va, obtained from Italian injecting drug users (IDUs) has indicated that these isolates belong to the HTLV-IIb subtype. To establish whether Italian IDUs are also infected by the HTLV-IIa variant, sequencing of the


Feline immunodeficiency virus: an epidemiological review.
C R Acad Sci III. 1994 Dec;317(12):1123-34. Unique Identifier : AIDSLINE MED/95211569
Courchamp F; Pontier D; URA CNRS 243, Universite Claude-Bernard, Lyon I, Villeurbanne,; France.
From a synthesis of 59 serosurveys, we estimate and discuss influence of several parameters on feline immunodeficiency virus (FIV) infection. The overall infection rate estimated from 85,529 tested cats is high, 11.04%, besides the virus seems to be rather endemic. Parameters influencing FIV infection are sex, age and


Rapid oral desensitization for sulfonamides in patients with the acquired immunodeficiency syndrome.
Ann Allergy Asthma Immunol. 1995 Feb;74(2):140-6. Unique Identifier : AIDSLINE MED/95211574
Moreno JN; Poblete RB; Maggio C; Gagnon S; Fischl MA; Department of Medicine, University of Miami School of Medicine.
BACKGROUND: A prospective case series was undertaken in a university teaching hospital. OBJECTIVE: To evaluate the safety and efficacy of two oral desensitization procedures for sulfonamides in patients with the acquired immunodeficiency syndrome (AIDS). METHODS: A rapid oral desensitization protocol to sulfadiazine (


Selective decrease in human immunodeficiency virus type 1 (HIV-1)-induced alpha interferon production by peripheral blood mononuclear cells during HIV-1 infection.
Clin Diagn Lab Immunol. 1995 Mar;2(2):138-42. Unique Identifier : AIDSLINE MED/95211624
Ferbas J; Navratil J; Logar A; Rinaldo C; Department of Infectious Diseases and Microbiology, University of; Pittsburgh Graduate School of Public Health, Pennsylvania.
We previously reported that human immunodeficiency virus type 1 (HIV-1), herpes simplex virus (HSV), and Sendai virus induce higher levels of alpha interferon (IFN-alpha) in blood dendritic cells than in monocytes of healthy donors. In the present study, the levels of IFN-alpha induced by T-cell tropic (IIIb and RF) a


Differential effect of the immunomodulatory hormone somatostatin on replication of human immunodeficiency virus type 1 in CD4+ and CD8+ T lymphocytes.
Clin Diagn Lab Immunol. 1995 Mar;2(2):192-8. Unique Identifier : AIDSLINE MED/95211634
Mercure L; Phaneuf D; Wainberg MA; Lady Davis Institute, Jewish General Hospital, Montreal, Quebec,; Canada.
The long-acting somatostatin analog octreotide (SMS 201-995) possesses immunosuppressive properties and has been successfully used for the management of human immunodeficiency virus (HIV)-associated diarrhea, a condition commonly observed in the absence of known enteric pathogens. Since HIV type 1 (HIV-1) replication


Immune response to sulfamethoxazole in patients with AIDS.
Clin Diagn Lab Immunol. 1995 Mar;2(2):199-204. Unique Identifier : AIDSLINE MED/95211635
Daftarian MP; Filion LG; Cameron W; Conway B; Roy R; Tropper F; Diaz-Mitoma F; Department of Microbiology and Immunology, University of Ottawa,; Ontario, Canada.
Antibody- and cell-mediated responses to sulfamethoxazole (SMX) were analyzed in AIDS patients with or without a history of hypersensitivity and in negative controls. In 20 of 20 (P


Flow cytometric analyses of the lymphocyte subsets in peripheral blood of children with untreated active juvenile dermatomyositis.
Clin Diagn Lab Immunol. 1995 Mar;2(2):205-8. Unique Identifier : AIDSLINE MED/95211636
O'Gorman MR; Corrochano V; Roleck J; Donovan M; Pachman LM; Department of Pediatrics, Northwestern University Medical School,; Chicago, Illinois 60614.
Juvenile dermatomyositis (JDMS) is a vasculopathy affecting primarily skin and muscle. Although the etiology is unknown, immunopathogenetic mechanisms appear to play a role in both the susceptibility to the disease and its progression. We measured the percentage and absolute numbers of B cells and T-cell subsets in th


Long-term serologic follow-up of hepatitis C virus-seropositive homosexual men.
Clin Diagn Lab Immunol. 1995 Mar;2(2):219-24. Unique Identifier : AIDSLINE MED/95211639
Ndimbie OK; Nedjar S; Kingsley L; Riddle P; Rinaldo C; Department of Pathology, University of Pittsburgh Medical Center,; Pennsylvania.
Hepatitis C virus (HCV) infection may go undiagnosed and continue to present a source of community-acquired or transfusion-associated infection because of shortcomings in sensitivity, specificity, and reproducibility of serologic tests. This project was designed to longitudinally study persons who were HCV seropositiv


The immunosuppressive human placental ferritin subunit p43 is produced by activated CD4+ lymphocytes.
Clin Diagn Lab Immunol. 1995 Mar;2(2):225-6. Unique Identifier : AIDSLINE MED/95211640
Garty B; Kaminsky E; Moroz C; Department of Pediatrics, Children's Medical Center of Israel,; Petah Tiqva.
Human placental ferritin is an immunosuppressive protein composed of a 43-kDa subunit (p43) and ferritin light chains. Its physiological action seems to be downregulation of the immune response of the mother against her embryo. Elevated levels of p43 in serum are associated with pregnancy, lymphomas, breast cancer, an


Hematological reference ranges among healthy Ugandans.
Clin Diagn Lab Immunol. 1995 Mar;2(2):233-5. Unique Identifier : AIDSLINE MED/95211642
Tugume SB; Piwowar EM; Lutalo T; Mugyenyi PN; Grant RM; Mangeni FW; Pattishall K; Katongole-Mbidde E; Joint Clinical Research Centre, Makerere University Medical; School, Kampala, Uganda.
Reference values are essential for the interpretation of hematologic data in clinical practice and research studies. Symptom-free human immunodeficiency virus antibody-negative Ugandan adults (183 subjects, aged 15 to 74 years, 37.7% women and 62.3% men) were studied to establish hematological reference ranges. The ce


beta-2 Microglobulin values among human immunodeficiency virus (HIV)-negative, HIV-positive asymptomatic, and HIV-positive symptomatic Ugandans.
Clin Diagn Lab Immunol. 1995 Mar;2(2):236-7. Unique Identifier : AIDSLINE MED/95211643
Piwowar EM; Tugume SB; Grant RM; Lutalo T; Pattishall K; Katongole-Mbidde E; University Hospitals of Cleveland, Ohio.
Mean serum beta-2 microglobulin levels among healthy human immunodeficiency virus-seronegative and asymptomatic and symptomatic human immunodeficiency virus-seropositive Ugandans were found to be 2.35, 3.75, and 5.06 mg/liter, respectively (P


Methods for detection of an intestinal secretory immunoglobulin A response to Candida spp. and their preliminary application in human immunodeficiency virus-infected patients with chronic diarrhea.
Clin Diagn Lab Immunol. 1995 Mar;2(2):246-8. Unique Identifier : AIDSLINE MED/95211646
Scerpella EG; Gould SS; Mathewson JJ; DuPont HL; Center for Infectious Diseases, University of Texas Medical; School, Houston.
Six of 11 human immunodeficiency virus (HIV)-infected patients with chronic diarrhea, shedding only Candida spp. in their stools, elicited a Candida-specific secretory immunoglobulin A response. Similar responses were identified in only 1 of 10 HIV-positive patients with chronic diarrhea but without Candida spp. and i


Alterations in levels of CD28-/CD8+ suppressor cell precursor and CD45RO+/CD4+ memory T lymphocytes in the peripheral blood of multiple sclerosis patients.
Clin Diagn Lab Immunol. 1995 Mar;2(2):249-52. Unique Identifier : AIDSLINE MED/95211647
Crucian B; Dunne P; Friedman H; Ragsdale R; Pross S; Widen R; Department of Medical Microbiology/Immunology, College of; Medicine, University of South Florida, Tampa.
A comprehensive peripheral blood immunophenotype analysis of 16 multiple sclerosis (MS) patients was performed by three-color flow cytometric analysis, and the results were compared with those for age-matched healthy controls. The cell subsets quantified included T cells (CD3+), B cells (CD19+), NK cells (CD56+), CD4+


Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines.
Immunity. 1995 Mar;2(3):271-9. Unique Identifier : AIDSLINE MED/95211654
Sad S; Marcotte R; Mosmann TR; Department of Immunology, University of Alberta, Edmonton,; Canada.
Alloantigen-stimulated CD8+ mouse spleen cells, either spontaneously or in the presence of IL-12 or IFN gamma plus anti-IL-4, differentiate into CD8+ T cells secreting a Th1-like cytokine pattern ( IL-2 and IFN gamma). IL-4 induced differentiation into CD8+ T cells secr


HIV infection in prisons [letter; comment]
Can Med Assoc J. 1995 Mar 15;152(6):812-3. Unique Identifier : AIDSLINE MED/95211683
Parker JE
HIV infection in prisons [letter; comment]
Can Med Assoc J. 1995 Mar 15;152(6):813. Unique Identifier : AIDSLINE MED/95211684
Williams B
Hand-foot syndrome associated with liposome-encapsulated doxorubicin therapy.
Cancer. 1995 Apr 15;75(8):2169-73. Unique Identifier : AIDSLINE MED/95211722
Gordon KB; Tajuddin A; Guitart J; Kuzel TM; Eramo LR; VonRoenn J; Department of Dermatology, Northwestern University Medical; School, Chicago, IL 60611, USA.
BACKGROUND. Acquired immune deficiency syndrome (AIDS)-related Kaposi s sarcoma (KS) is a common complication of patients infected with human immunodeficiency virus and can cause significant morbidity. Long term therapy with standard chemotherapeutic regimens has been limited by relatively short durations of response


Characterization of immune suppression by a synthetic HIV gp41 peptide.
Cell Immunol. 1995 Apr 1;161(2):236-43. Unique Identifier : AIDSLINE MED/95211858
Wang H; Nishanian P; Fahey JL; Center for Interdisciplinary Research in Immunology and Disease,; UCLA School of Medicine 90024.
HIV infection is associated with immunosuppression leading to susceptibility to opportunistic infections and tumors. HIV proteins can be immunosuppressive with substantial activity residing within the gp41 portion of HIV envelope glycoprotein gp160. In this report, immunosuppressive properties of a synthetic peptide c


Synthesis and human immunodeficiency virus (HIV)-1 protease inhibitory activity of tripeptide analogues containing a dioxoethylene moiety.
Chem Pharm Bull (Tokyo). 1994 Dec;42(12):2636-40. Unique Identifier : AIDSLINE MED/95211903
Kitazaki T; Asano T; Kato K; Kishimoto S; Itoh K; Pharmaceutical Research Laboratories III, Takeda Chemical; Industries, Ltd., Osaka, Japan.
Tripeptide analogues 2 and 3 containing a dioxoethylene moiety were designed based on the characteristic structure of the naturally occurring human immunodeficiency virus (HIV)-1 protease inhibitors RPI-856 A, B, C and D (1). The compounds (2, 3) prepared showed hig


Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood.
Clin Exp Immunol. 1995 Apr;100(1):164-72. Unique Identifier : AIDSLINE MED/95212053
Kummer JA; Kamp AM; Tadema TM; Vos W; Meijer CJ; Hack CE; Central Laboratory of the Netherlands Red Cross Blood Transfusion; Service, Amsterdam.
Cytoplasmic granules from activated natural killer (NK) and cytotoxic T lymphocytes (CTL) contain a pore-forming protein, perforin, and several homologous serine proteinases called granzymes. Expression of these proteins correlates with the cytolytic potential of cytotoxic lymphocytes. Using a panel of MoAbs specific


Autoproliferation in HIV-1-infected patients undergoing active HIV-1-specific immunotherapy.
Clin Exp Immunol. 1995 Apr;100(1):7-12. Unique Identifier : AIDSLINE MED/95212064
Trauger RJ; Giermakowska W; Wormsley S; Turner J; Jensen FC; Carlo DJ; Immune Response Corporation, Carlsbad, CA, USA.
We have observed a treatment-associated autoproliferative response in cultured peripheral blood mononuclear cells (PBMC) of asymptomatic HIV-1-infected subjects receiving a gp120-depleted, inactivated HIV-1 antigen in incomplete Freund s adjuvant (IFA; HIV-1 Immunogen). The frequency and magnitude of the autoprolifera


The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25.
Cytogenet Cell Genet. 1995;69(3-4):223-5. Unique Identifier : AIDSLINE MED/95212162
Calabrese G; Sures I; Pompetti F; Natoli G; Palka G; Iacobelli S; Istituto di Biologia e Genetica, Universita G. D'Annunzio,; Chieti, Italy.
Levels of a 90-kDa tumor associated protein, designated 90K (gene symbol LGALS3BP), have been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). 90K appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated


Pentamidine-induced derangements of glucose homeostasis. Determinant roles of renal failure and drug accumulation. A study of 128 patients.
Diabetes Care. 1995 Jan;18(1):47-55. Unique Identifier : AIDSLINE MED/95212191
Assan R; Perronne C; Assan D; Chotard L; Mayaud C; Matheron S; Zucman D; Service de Diabetologie, Hopital Bichat, Paris, France.
OBJECTIVE--To assess the prevalence, presentation, and risk factors of pentamidine-induced dysglycemia. RESEARCH DESIGN AND METHODS--Blood glucose values were screened in 244 consecutive immunocompromised patients with Pneumocystis carinii pneumonia: 116 being treated with cotrimoxazole and 128 others with pentamidine


Immunobiology of Mycobacterium avium infection.
Eur J Clin Microbiol Infect Dis. 1994 Nov;13(11):1000-6. Unique Identifier : AIDSLINE MED/95212311
Bermudez LE; Kuzell Institute for Arthritis and Infectious Diseases, San; Francisco, California 94115, USA.
Infection caused by organisms of the Mycobacterium avium complex is diagnosed in 50% to 60% of AIDS patients with the advanced stage of disease. Mycobacterium avium is an environmental bacterium that gains access to the host through both the gastrointestinal tract and the respiratory tract. After crossing the mucosal


Tuberculosis at the end of the twentieth century.
Eur J Clin Microbiol Infect Dis. 1994 Nov;13(11):902-7. Unique Identifier : AIDSLINE MED/95212313
Sepkowitz KA; Raffalli J; Division of Infectious Diseases, Memorial Sloan-Kettering Cancer; Center, New York, New York 10021, USA.
Tuberculosis has once again emerged as a significant public health problem in Western countries. Much of the rise has been fueled by the growing numbers of persons infected with HIV. Co-infection with Mycobacterium tuberculosis and HIV has been shown to result in high rates of active tuberculosis, and possibly in acce


Mycobacterium avium complex: advances in therapy.
Eur J Clin Microbiol Infect Dis. 1994 Nov;13(11):915-24. Unique Identifier : AIDSLINE MED/95212315
Havlir DV; Department of Internal Medicine, University of California, San; Diego 92103, USA.
Disseminated Mycobacterium avium complex (MAC) is one of the most common opportunistic infections in AIDS patients and is increasingly recognized as a significant pathogen in chronic pulmonary disease in nonimmunocompromised patients. Important progress in therapy has occurred over the last several years. In AIDS pati


Mycobacterium genavense: an emerging pathogen.
Eur J Clin Microbiol Infect Dis. 1994 Nov;13(11):932-6. Unique Identifier : AIDSLINE MED/95212317
Bottger EC; Institut fur Medizinische Mikrobiologie, Medizinische Hochschule; Hannover, Germany.
Disseminated mycobacterial infection, often due to Mycobacterium avium complex, occurs frequently in patients with AIDS. More recently, a newly identified mycobacterium, Mycobacterium genavense, has been repeatedly isolated from AIDS patients. Mycobacterium genavense has unusual fastidious growth requirements and show


Antimycobacterial susceptibility testing: present practices and future trends.
Eur J Clin Microbiol Infect Dis. 1994 Nov;13(11):980-93. Unique Identifier : AIDSLINE MED/95212322
Inderlied CB; Department of Pathology, University of Southern California, Los; Angeles, USA.
Along with the worldwide renewed interest in tuberculosis, the high incidence of non-tuberculous disease in HIV-infected patients and the continuing problem of disease caused by rapidly growing mycobacteria, there has been a renewed interest in mycobacterial susceptibility testing. This renewed interest stems from the


Secretion of leukaemia inhibitory factor after allogeneic bone marrow transplantation: a study of CD4+ and CD8+ TCR alpha beta+ T-cell clones derived from four leukaemia patients.
Eur J Haematol. 1995 Feb;54(2):106-10. Unique Identifier : AIDSLINE MED/95212514
Bruserud O; Hamann W; Pawelec G; Second Department of Internal Medicine, Tubingen University; Medical Clinic, FRG.
CD4+ and CD8+ TCR alpha beta+ T-cell clones were derived from 4 leukaemia patients early (4-6 weeks) after allogeneic bone marrow transplantation. Leukemia inhibitory factor (LIF) secretion in response to the activation signal accessory cells (AC) + phytohaemagglutinin (PHA) was investigated for each individual clone.


DNA binding properties of the zinc-bound and zinc-free HIV nucleocapsid protein: supercoiled DNA unwinding and DNA-protein cleavable complex formation.
FEBS Lett. 1995 Mar 27;362(1):59-64. Unique Identifier : AIDSLINE MED/95212584
Priel E; Aflalo E; Seri I; Henderson LE; Arthur LO; Aboud M; Segal S; Blair DG; Department of Immunology and Microbiology, Faculty of Health; Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
The HIV nucleocapsid (NC) protein contains, as those of other retroviruses, two Cys-His arrays which function as zinc finger binding domains. The nucleic acid binding properties of retroviral NC have been previously demonstrated. In this study, we characterized the DNA binding ability of the zinc-bound and zinc-free f


Contraceptive use and the risk of HIV infection in Nairobi, Kenya.
Int J Gynaecol Obstet. 1995 Jan;48(1):61-7. Unique Identifier : AIDSLINE MED/95212619
Mati JK; Hunter DJ; Maggwa BN; Tukei PM; Department of Obstetrics and Gynaecology, University of Nairobi,; Kenya.
OBJECTIVES: To determine: (a) the prevalence of human immunodeficiency virus-1 (HIV-1) infection among women attending family planning clinics in Nairobi; and (b) the associations between contraceptive use and HIV infection. METHODS: History, clinical examination and laboratory tests were used to obtain data from 4404


Intestinal function and injury in acquired immunodeficiency syndrome-related cryptosporidiosis.
Gastroenterology. 1995 Apr;108(4):1075-82. Unique Identifier : AIDSLINE MED/95212825
Goodgame RW; Kimball K; Ou CN; White AC Jr; Genta RM; Lifschitz CH; Chappell CL; Department of Medicine, Baylor College of Medicine, Houston,; Texas.
BACKGROUND/AIMS: The pathogenesis of the diarrhea in acquired immunodeficiency syndrome (AIDS)-related cryptosporidiosis is not known. The hypothesis of this study was that the intestinal dysfunction and injury are related to the number of organisms infecting the intestinal mucosa. The aim of this study was to study t


Symptomatic hypoparathyroidism in acquired immunodeficiency syndrome.
Horm Res. 1994;42(6):295-9. Unique Identifier : AIDSLINE MED/95212993
Lehmann R; Leuzinger B; Salomon F; Division of Endocrinology and Metabolism, University Hospital of; Zurich, Switzerland.
Involvement of endocrine organs is frequent in patients with HIV infections. We report the first case of symptomatic hypoparathyroidism in a patient in the course of HIV infection. He presented with tetany and hypocalcemia in the presence of decreased levels of parathyroid hormone, which persisted after correction of


Anal carcinoma--a histological review.
Histopathology. 1994 Dec;25(6):507-16. Unique Identifier : AIDSLINE MED/95212994
Williams GR; Talbot IC; ICRF Colorectal Unit, St Mark's Hospital, London.
Epidemiological evidence of an association between anal carcinoma and symptomatic HIV-related disease suggests that the number of cases of this disease may increase significantly over the next few years. The role of oncogenic HPV types in the pathogenesis of anal carcinoma is substantiated by both epidemiological evid


Heterogeneity of Epstein-Barr virus infection in angioimmunoblastic lymphadenopathy type T-cell lymphoma.
Histopathology. 1994 Dec;25(6):569-79. Unique Identifier : AIDSLINE MED/95213000
Ohshima K; Takeo H; Kikuchi M; Kozuru M; Uike N; Masuda Y; Yoneda S; Takeshita M; Shibata T; Akamatsu M; Department of Pathology, School of Medicine, Fukuoka University,; Japan.
To investigate the relationship of Epstein-Barr virus (EBV) and angioimmunoblastic lymphadenopathy with dysproteinemia, we performed DNA analysis using the polymerase chain reaction (PCR), Southern blot, in situ hybridization, and immunohistochemical analysis of lymph nodes in five patients who were followed up and bi


Xanthomatosis pseudotumour of the stomach after chemotherapy for gastric lymphoma in a patient with acquired immunodeficiency syndrome.
Histopathology. 1994 Dec;25(6):589-91. Unique Identifier : AIDSLINE MED/95213004
Fernandez-Alonso J; Medina-Perez M; Gomez-Izquierdo L; Department Anatomic Pathology, University Hospital, Sevilla,; Spain.
Antigen-induced death of mature T lymphocytes: analysis by flow cytometry.
Immunol Rev. 1994 Dec;142:157-74. Unique Identifier : AIDSLINE MED/95213064
Kabelitz D; Oberg HH; Pohl T; Pechhold K; Dept. of Immunology, Paul Ehrlich Institute, Langen, Germany.
From AIDS to parasite infection: pathogen-mediated subversion of programmed cell death as a mechanism for immune dysregulation.
Immunol Rev. 1994 Dec;142:9-51. Unique Identifier : AIDSLINE MED/95213075
Ameisen JC; Estaquier J; Idziorek T; INSERM U415 Pathogenese du sida et des infections a tropisme; immunitaire et nerveux, Institut Pasteur, Lille, France.
Premature cell death can result either from cell injury or degeneration, leading to necrosis, or from the activation of a physiological cell-suicide process, termed programmed cell death or apoptosis, that is regulated by intercellular signalling. This process plays an essential role in the selection of developing lym


Intestinal microsporidiosis in patients with acquired immunodeficiency syndrome--report of three more German cases.
Infection. 1994 Nov-Dec;22(6):417-9. Unique Identifier : AIDSLINE MED/95213116
Franzen C; Fatkenheuer G; Salzberger B; Muller A; Mahrle G; Diehl V; Schrappe M; Klinik I fur Innere Medizin der Universitat zu Koln, Germany.
Intestinal microsporidiosis with Enterocytozoon bieneusi was diagnosed in three of 18 HIV-infected patients with chronic diarrhoea. In two cases all known stages of the life cycle of E. bieneusi (merogonial plasmodia, sporogonial plasmodia, sporoblasts, spores) were fo


Cutaneous biopsies for diagnosis of histoplasmosis in an HIV patient [letter]
Infection. 1994 Nov-Dec;22(6):426-7. Unique Identifier : AIDSLINE MED/95213120
Petit N; Bonnet E; Chapel F; Bensa P; Gallais H; Lebreuil G
Pooling of paper-adsorbed blood samples to reduce the cost of anti-HIV testing in epidemiological studies [letter]
Infection. 1994 Nov-Dec;22(6):428-9. Unique Identifier : AIDSLINE MED/95213121
Ippolito G; Puro V; Costa F; Stegagno M
The risks of HIV transmission from haemophilic patients to orthopaedic surgeons [editorial]
Int Orthop. 1994;18(6):331. Unique Identifier : AIDSLINE MED/95213137
Rodriguez Merchan EC
AIDS and surgery.
Int Orthop. 1994;18(6):397-9. Unique Identifier : AIDSLINE MED/95213152
Perugia L; Traina GC; Istituto de Clinica Ortopedica e Traumatologia, Universita degli; Studi La Sapienza, Rome, Italy.
Early studies on a candidate intracellular subunit vaccine NFU.Ac.HIV[JM] for prevention and/or modification of HIV-related disease.
Intervirology. 1994;37(5):259-68. Unique Identifier : AIDSLINE MED/95213157
Skinner GR; Davies JA; Sheasby M; Mahmood N; Department of Infection, University of Birmingham, UK.
A candidate HIV subunit vaccine NFU.Ac.HIV[JM] was prepared by detergent and formaldehyde treatment of HIV-infected JM cells. The preparation contained HIV polypeptides at 200, 118, 70, 41 and 24 kD, with reactivity by immunoblotting of approximately fifteen virus-specific polypeptides including polypeptides at 119, 5


Comparison of fibrosarcomas that developed at vaccination sites and at nonvaccination sites in cats: 239 cases (1991-1992).
J Am Vet Med Assoc. 1994 Nov 15;205(10):1425-9. Unique Identifier : AIDSLINE MED/95213221
Hendrick MJ; Shofer FS; Goldschmidt MH; Haviland JC; Schelling SH; Engler SJ; Gliatto JM; Department of Pathobiology, School of Veterinary Medicine,; University of Pennsylvania, Philadelphia 19104.
Questionnaires were sent to veterinarians who had submitted a fibrosarcoma from a cat to the surgical pathology services of the veterinary schools of the University of Pennsylvania and Tufts University between Jan 1, 1991 and June 30, 1992. Questionnaire items included signalment, FeLV and feline immunodeficiency viru


Isolation of the newly described species Mycobacterium celatum from AIDS patients.
J Clin Microbiol. 1995 Jan;33(1):137-40. Unique Identifier : AIDSLINE MED/95213339
Tortoli E; Piersimoni C; Bacosi D; Bartoloni A; Betti F; Bono L; Burrini C; De Sio G; Lacchini C; Mantella A; et al; Laboratorio di Microbiologia e Virologia, Ospedale di Careggi,; Florence, Italy.
Mycobacterium celatum is a recently described species which, on the basis of conventional tests, may be misidentified as Mycobacterium xenopi or as belonging to the Mycobacterium avium complex. Only genomic sequencing or high-performance liquid chromatography of cell wall mycolic acids can presently allow a correct id


Quantitative molecular monitoring of human immunodeficiency virus type 1 activity during therapy with specific antiretroviral compounds.
J Clin Microbiol. 1995 Jan;33(1):16-23. Unique Identifier : AIDSLINE MED/95213344
Bagnarelli P; Menzo S; Valenza A; Paolucci S; Petroni S; Scalise G; Sampaolesi R; Manzin A; Varaldo PE; Clementi M; Institute of Microbiology, University of Ancona, Italy.
Methods for the absolute quantitation of nucleic acids present in small amounts in biological samples (competitive PCR and competitive reverse transcription PCR) were applied to the direct monitoring of specific anti-human immunodeficiency virus type 1 (HIV-1) therapy. With these techniques, different parameters of HI


Low human immunodeficiency virus type 1 (HIV-1) DNA burden as a major cause for failure to detect HIV-1 DNA in clinical specimens by PCR.
J Clin Microbiol. 1995 Jan;33(1):205-8. Unique Identifier : AIDSLINE MED/95213354
Zazzi M; Romano L; Catucci M; De Milito A; Almi P; Gonnelli A; Rubino M; Valensin PE; Department of Molecular Biology, University of Siena, Italy.
To determine the sensitivity of a nested PCR procedure for detecting human immunodeficiency virus type 1 DNA in clinical specimens, 553 peripheral blood mononuclear cell samples obtained from 268 human immunodeficiency virus type 1-seropositive subjects were assayed by use of two independent primer sets for each sampl


Quantitative analysis of syncytium-inducing and non-syncytium-inducing virus in patients infected with human immunodeficiency virus type 1.
J Clin Microbiol. 1995 Jan;33(1):212-4. Unique Identifier : AIDSLINE MED/95213356
Shafer RW; Aguiniga E; Merigan TC; Center for AIDS Research, Stanford University School of Medicine,; California 94305.
Among 75 consecutive human immunodeficiency virus type 1 (HIV-1)-infected patients with moderate and advanced immunosuppression, those harboring syncytium-inducing (SI) HIV-1 had a lower CD(4+)-cell count (145 versus 278 cells per microliter, P


Length of incubation time for human immunodeficiency virus cultures.
J Clin Microbiol. 1995 Jan;33(1):246-7. Unique Identifier : AIDSLINE MED/95213367
Fiscus SA; Welles SL; Spector SA; Lathey JL; Department of Microbiology and Immunology, University of North; Carolina at Chapel Hill 27599.
Qualitative human immunodeficiency virus culture is a slow, labor-intensive, and expensive procedure, yet critical for the diagnosis of infants born to human immunodeficiency virus-seropositive mothers. We report that the cultures can be terminated at day 21 with minimal false-negative results but with considerable sa


Effect of delayed specimen processing on cytomegalovirus antigenemia test results.
J Clin Microbiol. 1995 Jan;33(1):257-9. Unique Identifier : AIDSLINE MED/95213371
Landry ML; Ferguson D; Cohen S; Huber K; Wetherill P; Clinical Virology Laboratory, Yale New Haven Hospital,; Connecticut 06510.
Blood samples held at either 4 degrees C or room temperature for 1 day had similar mean decreases in number of cytomegalovirus antigenemia-positive cells (52 to 55%) and similar false-negative test results (13 to 14%). After 2 days, samples held at 4 degrees C showed no further dec


Detection of p24 antigen with and without immune complex dissociation for longitudinal monitoring of human immunodeficiency virus type 1 infection.
J Clin Microbiol. 1995 Jan;33(1):72-5. Unique Identifier : AIDSLINE MED/95213384
Henrard DR; Wu S; Phillips J; Wiesner D; Phair J; Abbott Laboratories, North Chicago, Illinois 60064.
Sequential specimens obtained from 87 multicenter AIDS cohort study participants were tested by three p24 antigen tests. They included a polyclonal enzyme immunoassay (EIA), a monoclonal EIA, and a monoclonal EIA after immune complex dissociation (ICD) of specimens. Subjects were grouped into two categories defined by


Involvement of multiple Cryptococcus neoformans strains in a single episode of cryptococcosis and reinfection with novel strains in recurrent infection demonstrated by random amplification of polymorphic DNA and DNA fingerprinting [see comments]
J Clin Microbiol. 1995 Jan;33(1):99-102. Unique Identifier : AIDSLINE MED/95213391
Haynes KA; Sullivan DJ; Coleman DC; Clarke JC; Emilianus R; Atkinson C; Cann KJ; Department of Medical Microbiology, Charing Cross and Westminster; Medical School, London, United Kingdom.
We compared the abilities of random amplification of polymorphic DNA and DNA fingerprinting, with oligonucleotide probes, to type five pairs of Cryptococcus neoformans clinical isolates recovered from five separate human immunodeficiency virus-positive patients in London, England. The two techniques had comparable dis


A new role for community organizations in the prevention and control of tuberculosis.
J Community Health. 1995 Feb;20(1):15-28. Unique Identifier : AIDSLINE MED/95213423
Freudenberg N; Center on AIDS, Drugs and Community Health, Hunter College, City; University of New York, New York 10010, USA.
The resurgence of tuberculosis in the United States has forced public health officials to reconsider the most appropriate strategies for its prevention and control. Many recent reports have suggested that the priority of public health programs should be to identify those with active tu


Tuberculosis: a health education imperative returns.
J Community Health. 1995 Feb;20(1):29-57. Unique Identifier : AIDSLINE MED/95213424
White GL Jr; Henthorne BH; Barnes SE; Segarra JT; Center for Community Health, University of Southern Mississippi,; Hattiesburg, USA.
The ominous resurgence of tuberculosis after many years of containment necessitates a review of the various factors responsible. An intense collaborative effort is needed to avoid potentially catastrophic consequences of the new epidemic. To provide a basis for health education recommendations, the factors contributin


Proliferation and phenotype of bovine mononuclear leukocytes in cultures stimulated by pokeweed mitogen.
J Dairy Sci. 1994 Dec;77(12):3592-600. Unique Identifier : AIDSLINE MED/95213458
Franklin ST; Young JW; Nonnecke BJ; Department of Animal Science, Iowa State University, Ames 50011.
Cell proliferation and phenotype were evaluated at 2, 4, 6, 8, 10, 12, and 14 d in cultures of bovine peripheral blood mononuclear leukocytes stimulated by pokeweed mitogen. Cell numbers in unstimulated and stimulated 2-d cultures decreased to about 45% of the number originally added. Cell numbers at 6 d in stimulated


RD intervention improved nutritional status [letter; comment]
J Am Diet Assoc. 1995 Apr;95(4):412. Unique Identifier : AIDSLINE MED/95213500
Saudny-Unterberg H; Gray-Donald K
Dietary intake and counseling, weight maintenance, and the course of HIV infection.
J Am Diet Assoc. 1995 Apr;95(4):428-32; quiz 433-5. Unique Identifier : AIDSLINE MED/95213507
Chlebowski RT; Grosvenor M; Lillington L; Sayre J; Beall G; Division of Medical Oncology, UCLA School of Medicine,; Harbor-UCLA Medical Center, Torrance 90509, USA.
OBJECTIVE: To define relationships among dietary intake and counseling, weight maintenance, and the clinical course of patients infected with the human immunodeficiency virus (HIV). DESIGN: A prospective cohort study in an HIV clinic in a county hospital. SUBJECTS: HIV-infected patients (68 with and 40 without acquire


Home-delivered meal programs for homebound people with HIV/AIDS.
J Am Diet Assoc. 1995 Apr;95(4):476-81. Unique Identifier : AIDSLINE MED/95213514
Kraak VI; God's Love We Deliver, New York, NY, USA.
In major cities within the past decade, 17 community-based, home-delivered meal programs have emerged to meet the specialized nutrition needs of homebound people living with the human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (HIV/AIDS). This review includes specifics about these meal programs: f


Liver involvement in AIDS-associated malignancies [letter]
J Hepatol. 1994 Dec;21(6):1145-6. Unique Identifier : AIDSLINE MED/95213569
Antinori S; Ridolfo AL; Esposito R; Vago L; Moroni M
Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor.
J Exp Med. 1995 Apr 1;181(4):1285-92. Unique Identifier : AIDSLINE MED/95213653
Mahon BP; Katrak K; Nomoto A; Macadam AJ; Minor PD; Mills KH; Department of Biology, St. Patrick's College, Maynooth, County; Kildare, Ireland.
The current understanding of the function of CD4+ T helper (Th) cells in immunity to infectious diseases is that Th1 cells, which secrete interleukin (IL)-2 and interferon-gamma, induce cellular immune responses, whereas Th2 cells, which secrete IL-4, IL-5, IL-6, and IL-10, provide helper function for humoral immunity


Infection of gamma/delta T lymphocytes by human herpesvirus 6: transcriptional induction of CD4 and susceptibility to HIV infection.
J Exp Med. 1995 Apr 1;181(4):1303-10. Unique Identifier : AIDSLINE MED/95213655
Lusso P; Garzino-Demo A; Crowley RW; Malnati MS; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892, USA.
Human herpesvirus 6 (HHV-6), a T-lymphotropic human herpesvirus, is a potentially immunosuppressive agent that has been suggested to play a role as a cofactor in the natural history of human immunodeficiency virus (HIV) infection. We studied the interactions between HHV-6 and gamma/delta T lymphocytes, a subset of T c


Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics.
J Exp Med. 1995 Apr 1;181(4):1365-72. Unique Identifier : AIDSLINE MED/95213661
Klein MR; van Baalen CA; Holwerda AM; Kerkhof Garde SR; Bende RJ; Keet IP; Eeftinck-Schattenkerk JK; Osterhaus AD; Schuitemaker H; Miedema F; Department of Clinical Viro-Immunology, Central Laboratory of The; Netherlands Red Cross Blood Transfusion Service, Amsterdam.
To gain more insight into the role of HIV-1-specific cytotoxic T lymphocytes (CTL) in the pathogenesis of AIDS, we investigated temporal relations between HIV-1 Gag-specific precursor CTL (CTLp), HIV-1 viral load, CD4+ T cell counts, and T cell function. Six HIV-1-infected subjects, who were asymptomatic for more than


Molecular characterization of major histocompatibility complex class II gene expression and demonstration of antigen-specific T cell response indicate a new phenotype in class II-deficient patients.
J Exp Med. 1995 Apr 1;181(4):1411-23. Unique Identifier : AIDSLINE MED/95213666
Hauber I; Gulle H; Wolf HM; Maris M; Eggenbauer H; Eibl MM; Institute of Immunology, University of Vienna, Austria.
Major histocompatibility complex (MHC) class II deficiency is an inherited autosomal recessive combined immunodeficiency. The disease is known as bare lymphocyte syndrome (BLS). BLS is characterized by a lack of constitutive MHC class II expression on macrophages and B cells as well as a lack of induced MHC class II e


Neutrophils from human immunodeficiency virus (HIV)-seronegative donors induce HIV replication from HIV-infected patients' mononuclear cells and cell lines: an in vitro model of HIV transmission facilitated by Chlamydia trachomatis.
J Exp Med. 1995 Apr 1;181(4):1493-505. Unique Identifier : AIDSLINE MED/95213673
Ho JL; He S; Hu A; Geng J; Basile FG; Almeida MG; Saito AY; Laurence J; Johnson WD Jr; Division of International Medicine, Cornell University Medical; College, New York 10021, USA.
Infection with a sexually transmitted disease (STD) increases the risk for human immunodeficiency virus (HIV) infection. Polymorphonuclear leukocytes (PMNs) are recruited into the genital tract by STD pathogens, such as Chlamydia trachomatis. Semen of HIV-infected men contains HIV associated with mononuclear cells. Th


A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12.
J Exp Med. 1995 Apr 1;181(4):1527-37. Unique Identifier : AIDSLINE GENBANK/U19888
Skeiky YA; Guderian JA; Benson DR; Bacelar O; Carvalho EM; Kubin M; Badaro R; Trinchieri G; Reed SG; Infectious Disease Research Institute, Seattle, Washington 98104,; USA.
Leishmania braziliensis causes cutaneous and mucosal leishmaniasis in humans. Most patients with cutaneous leishmaniasis heal spontaneously and may therefore have developed protective immunity. There appears to be a mixed cytokine profile associated with active cutaneous or mucosal disease, and a dominant T helper (Th


Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein.
J Exp Med. 1995 Apr 1;181(4):1551-6. Unique Identifier : AIDSLINE GENBANK/M24914
Mucke L; Abraham CR; Ruppe MD; Rockenstein EM; Toggas SM; Mallory M; Alford M; Masliah E; Department of Neuropharmacology, Scripps Research Institute, La; Jolla, California 92037, USA.
Expression of the HIV-1 envelope protein gp120 in brains of transgenic (tg) mice induces extensive neurodegeneration (Toggas, S. M., E. Masliah, E. M. Rockenstein, G. F. Rall, C. R. Abraham, and L. Mucke. 1994. Nature [Lond.]. 367:188-193.). To further analyze the pathogenesis of gp120-induced neurotoxicity and to ass


Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.
J Exp Med. 1995 Apr 1;181(4):1569-74. Unique Identifier : AIDSLINE GENBANK/X02339
Pfeiffer C; Stein J; Southwood S; Ketelaar H; Sette A; Bottomly K; Section of Immunobiology, Yale University School of Medicine, New; Haven, Connecticut 06520-8011, USA.
Antigen priming of naive CD4 T cells can generate effector CD4 T cells that produce interleukin 4 (T helper [Th]2-like) or interferon-gamma (Th1-like). Using a system in which priming leads to responses dominated by one or the other of these cell types, we show that varying either the antigenic peptide or the major hi


Human T lymphocyte virus 1 from a leukemogenic cell line mediates in vivo and in vitro lymphocyte apoptosis.
J Exp Med. 1995 Apr 1;181(4):1575-80. Unique Identifier : AIDSLINE MED/95213682
Leno M; Simpson RM; Bowers FS; Kindt TJ; Laboratory of Immunogenetics, National Institute of Allergy and; Infectious Diseases, Rockville, Maryland 20852, USA.
HTLV-1 is implicated in the development of diverse diseases. However, most HTLV-1-infected individuals remain asymptomatic. How HTLV-1 infection leads to disparate consequences remains a mystery, despite extensive investigation of HTLV-1 isolates from infected individuals. As in human infection, experimental HTLV-1 in


An epidemic in Cuba of optic neuropathy, sensorineural deafness, peripheral sensory neuropathy and dorsolateral myeloneuropathy.
J Neurol Sci. 1994 Dec 1;127(1):11-28. Unique Identifier : AIDSLINE MED/95213732
Roman GC; Neuroepidemiology Branch, National Institute of Neurological; Disorders and Stroke, National Institutes of Health, Bethesda,; MD.
An epidemic outbreak of peripheral neuropathy affected Cuba in 1992-93 resulting in 50,862 cases (national cumulative incidence rate (CIR) 461.4 per 100,000). Clinical forms included retrobulbar optic neuropathy, sensory and dysauton


Persistent neuroleptic-induced rigidity and dystonia in AIDS dementia complex: a clinico-pathological case report.
J Neurol Sci. 1994 Dec 1;127(1):114-20. Unique Identifier : AIDSLINE MED/95213733
Factor SA; Podskalny GD; Barron KD; Albany Medical College, Department of Neurology, New York 12208.
Patients with AIDS dementia complex (ADC) appear to have an increased likelihood of developing acute onset parkinsonism and dystonia when treated with dopamine antagonists. It has been hypothesized, based on clinical evidence, that hypersensitivity to these drugs in ADC is probably


Progression of cytomegalovirus in the rabbit following the intraocular injection of the virus.
J Chemother. 1994 Dec;6(6):412-6. Unique Identifier : AIDSLINE MED/95213780
Narang HK; Public Health Laboratory, Newcastle General Hospital, Newcastle; Upon Tyne, UK.
There is growing recognition that cytomegalovirus ( CMV ) is one of the opportunistic infections in patients afflicted with AIDS. The purpose of the present study was to establish a chronic CMV infection of the central nervous


Viral measurement by polymerase chain reaction-based assays in human immunodeficiency virus-infected infants.
J Pediatr. 1995 Apr;126(4):592-5. Unique Identifier : AIDSLINE MED/95213896
Palumbo PE; Kwok S; Waters S; Wesley Y; Lewis D; McKinney N; Bardeguez A; Connor EM; Oleske JM; Department of Pediatrics, University of Medicine and Dentistry of; New Jersey-New Jersey Medical School, Newark 07103, USA.
Serial samples from human immunodeficiency virus-infected infants in the first year of life were analyzed by quantitative human immunodeficiency virus polymerase chain reaction assays. Very high, persistent levels of plasma RNA and proviral DNA were detected throughout the study period, suggesting the absence of an ef


Birth order, delivery route, and concordance in the transmission of human immunodeficiency virus type 1 from mothers to twins. International Registry of HIV-Exposed Twins.
J Pediatr. 1995 Apr;126(4):625-32. Unique Identifier : AIDSLINE MED/95213903
Duliege AM; Amos CI; Felton S; Biggar RJ; Goedert JJ; Biocine Company, Emeryville, California, USA.
BACKGROUND: We evaluated data from prospectively identified twins to understand better the mechanisms and covariates of mother-to-infant transmission of human immunodeficiency virus (HIV). METHODS: Using data obtained from an international collaboration and multivariate quasilikelihood modeling, we assessed concordanc


T lymphocyte subsets in primary antiphospholipid syndrome.
J Rheumatol. 1994 Dec;21(12):2242-5. Unique Identifier : AIDSLINE MED/95213986
Papo T; Piette JC; Legac E; Frances C; Grenot P; Debre P; Godeau P; Autran B; Department of Internal Medicine, Groupe Hospitalier; Pitie-Salpetriere, Paris, France.
OBJECTIVE. To study T, natural killer (NK) and B blood cell subsets in primary antiphospholipid syndrome (APS). METHODS. We studied 10 patients with primary APS and 12 healthy subjects. Blood lymphocytes counts, proportions of B cells (CD19+), total CD5 and CD5 B cells, NK cells (CD16+CD56+), T cells (CD3+), CD4+ help


Peripheral blood and synovial fluid mononuclear cell phenotypes in lentivirus induced arthritis.
J Rheumatol. 1995 Jan;22(1):8-15. Unique Identifier : AIDSLINE MED/95214058
Wilkerson MJ; Davis WC; Cheevers WP; Department of Veterinary Microbiology and Pathology, Washington; State University, Pullman 99164-7040.
OBJECTIVE. To identify the phenotypes and activation status of peripheral blood (PB) and synovial fluid (SF) mononuclear cells associated with caprine arthritis encephalitis virus (CAEV) induced arthritis in goats. METHODS. PB and SF mononuclear cells from 8 goats chronically infected with CAEV and 2 mock-infected goa


3-deaza- and 7-deaza-5'-noraristeromycin and their antiviral properties.
J Med Chem. 1995 Mar 17;38(6):1035-8. Unique Identifier : AIDSLINE MED/95214065
Siddiqi SM; Chen X; Rao J; Schneller SW; Ikeda S; Snoeck R; Andrei G; Balzarini J; De Clercq E; Department of Chemistry, University of South Florida, Tampa; 33620.
An enantiospecific synthesis of 3-deaza-5 -noraristeromycin as its dihydrochloride ((-)-6) has been accomplished in six steps beginning with the reaction of (+)-(1R,4S)-4-hydroxy-2-cyclopenten-1-yl acetate with 4-chloro-1H-imidazo[4,5-c]pyridine. The preparation of 7-deaza-5 -noraristeromycin ((-)-7) was described pre


Unsaturated acyclic analogues of 2'-deoxyadenosine and thymidine containing fluorine: synthesis and biological activity.
J Med Chem. 1995 Mar 17;38(6):875-82. Unique Identifier : AIDSLINE MED/95214072
Xu ZQ; Qiu YL; Chokekijchai S; Mitsuya H; Zemlicka J; Department of Chemistry, Michigan Cancer Foundation, Detroit; 48201.
The syntheses and biological activities of fluorobutynol 11 and (E)- and (Z)-fluorobutenols 8a,d and 9a,d are described. Alkylation of adenine with bromofluorobutyne 13a afforded intermediate 14 which was converted to fluorobutynol 11. Aldehyde 16a and (carbethoxyfluoromethyl)-triphenylphosphonium bromide furnished (E


Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.
J Med Chem. 1995 Mar 17;38(6):890-7. Unique Identifier : AIDSLINE MED/95214074
Raghavan K; Buolamwini JK; Fesen MR; Pommier Y; Kohn KW; Weinstein JN; Laboratory of Molecular Pharmacology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.
We present the results from a comparative molecular field analysis (CoMFA) of a set of flavone analogs that inhibit HIV-1 integrase-mediated cleavage (3 -processing step) and integration (strand transfer step) in vitro. The results indicate a strong correlation between the inhibitory activity of these flavones and the


Nonpeptidic potent HIV-1 protease inhibitors: (4-hydroxy-6-phenyl-2-oxo-2H- pyran-3-yl)thiomethanes that span P1-P2' subsites in a unique mode of active site binding.
J Med Chem. 1995 Mar 17;38(6):898-905. Unique Identifier : AIDSLINE MED/95214075
Prasad JV; Para KS; Tummino PJ; Ferguson D; McQuade TJ; Lunney EA; Rapundalo ST; Batley BL; Hingorani G; Domagala JM; et al; Department of Chemistry, Parke-Davis Pharmaceutical Research; Division, Warner-Lambert Company, Ann Arbor, Michigan 48106, USA.
Using molecular modeling and the information derived from the X-ray crystal structure of HIV-1 protease (HIV PR) complexed with the pyran-2-one 1, a series of (4-hydroxy-6-phenyl-2-oxo-2H-pyran-3-yl)thiomethanes was designed and analyzed as novel, nonpeptidic inhibitors of HIV PR. Structure-activity studies led to the


A maximum-likelihood approach to analyzing nonoverlapping and overlapping reading frames.
J Mol Evol. 1995 Feb;40(2):181-9. Unique Identifier : AIDSLINE MED/95214094
Hein J; Stovlbaek J; Institute of Biological Sciences, Aarhus University, Denmark.
A model is presented for sequence evolution on the basis of which one can analyze combinations of noncoding, singly coding, and multiply coding regions of aligned homologous DNA sequences. It is a generalization of Kimura s (J. Mol. Evol. 16:111-120, 1980) and Li et al. s (J. Mol. Evol. 36:96-99, 1985) transition-tran


[Anti adhesion therapy]
Nippon Rinsho. 1995 Mar;53(3):761-70. Unique Identifier : AIDSLINE MED/95214294
Yamada A; Murakami M; Uede T; Institute of Immunological Science, Hokkaido University.
[Detected Epstein-Barr virus genome using polymerase chain reaction in peripheral mononuclear cells--subacute necrotizing lymphadenitis]
Rinsho Byori. 1995 Feb;43(2):181-6. Unique Identifier : AIDSLINE MED/95214310
Hirai M; Tanaka K; Hasuike T; Ota K; Yasui Y; Nakao Y; Ohira H; Inoue T; Yamane T; Sasaki A; et al; Department of Clinical and Laboratory Medicine, Osaka City; University Medical School.
A 23-year old woman was admitted to our hospital because of fever, leukocytopenia, thrombocytopenia and cervical lymphadenopathy. From pathological findings of the cervical lymphnode she was diagnosed as subacute necrotizing lymphadenitis (SNL). Bone marrow aspiration was hypocellular with proliferation of mature hist


[Clinical investigation of severe pulmonary tuberculosis and miliary tuberculosis]
Kekkaku. 1995 Feb;70(2):87-91. Unique Identifier : AIDSLINE MED/95214357
Higaki K; Uno M; Shiraishi T; Sumita S; Ohno T; Ichikawa Y; Oizumi K; First Department of Internal Medicine, Kurume University School; of Medicine, Fukuoka, Japan.
Although the incidence of pulmonary tuberculosis had been rapidly decreased in Japan , it is pointed out that the rate of decrease in annual incidence became smaller in recent years. This slowing down of the rate of decrease is considered to be resulted from an increase in number of


Acute myelopathy and cerebellar signs associated with uveitis with positive serum and cerebrospinal fluid antibodies to HTLV-I.
Kurume Med J. 1994;41(4):193-7. Unique Identifier : AIDSLINE MED/95214430
Sato Y; Honda Y; Ohshima Y; Honda E; Oizumi K; Takeuchi N; Department of Neurology, Futase Social Insurance Hospital,; Iizuka, Japan.
A 55-year-old man was admitted because of weakness in the legs of a few days duration. Neurological examination revealed paraparesis, ataxia of the left limbs, superficial hypoesthesia below the T-10 dermatome level and urinary retention. The antibody titers to human T-lymphotropic virus type I (HTLV-I) were x640 in t


[Primary extralymphatic non-Hodgkin's lymphomas: the response to treatment and prognostic factors in 73 patients]
Med Clin (Barc). 1995 Mar 4;104(8):281-6. Unique Identifier : AIDSLINE MED/95214467
Oriol A; Ribera JM; Flores A; Batlle M; las Heras G; Vaquero M; Junca J; Milla F; Feliu E; Servicio de Hematologia, Hospital Universitari Germans Trias i; Pujol, Badalona.
BACKGROUND: The aim of the present study was to determine the prognostic factors for treatment response, relapse-free survival (RFS) and overall survival (OS) in a series of 73 patients with primary extranodal lymphomas (PEL). METHODS: All the patients diagnosed with PEL in one center from January 1984 to December 199


[2',3'-Dideoxyinosine and pancreatic disease in HIV infection (letter)]
Med Clin (Barc). 1995 Mar 4;104(8):319. Unique Identifier : AIDSLINE MED/95214478
Belda Mira A; Pascual Izuel JM; Gonzalvo Bellver F; Rovira Daudi E
Neurosyphilis in patients with human immunodeficiency virus infection [letter]
N Engl J Med. 1995 Apr 27;332(17):1169; discussion 1170-1. Unique Identifier : AIDSLINE MED/95214687
Rodriquez-Bano J; Izquierdo G; Muniain MA
Neurosyphilis in patients with human immunodeficiency virus infection [letter]
N Engl J Med. 1995 Apr 27;332(17):1169; discussion 1170-1. Unique Identifier : AIDSLINE MED/95214688
Tramont EC
Neurosyphilis in patients with human immunodeficiency virus infection [letter]
N Engl J Med. 1995 Apr 27;332(17):1170; discussion 1170-1. Unique Identifier : AIDSLINE MED/95214689
Gourevitch MN; Klein RS; Schoenbaum EE
Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection [see comments]
N Engl J Med. 1995 May 4;332(18):1181-5. Unique Identifier : AIDSLINE MED/95214703
Moore PS; Chang Y; Division of Epidemiology, School of Public Health, College of; Physicians and Surgeons, Columbia University, New York, NY 10032,; USA.
BACKGROUND. Herpesvirus-like DNA sequences have recently been found in lesions from patients with Kaposi s sarcoma and the acquired immunodeficiency syndrome (AIDS). It is not known whether these sequences are also present in classic Kaposi s sarcoma or in the Kaposi s sarcoma that occurs in homosexual men who are ser


Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas [see comments]
N Engl J Med. 1995 May 4;332(18):1186-91. Unique Identifier : AIDSLINE MED/95214704
Cesarman E; Chang Y; Moore PS; Said JW; Knowles DM; Department of Pathology, New York Hospital-Cornell Medical; Center, NY 10021, USA.
BACKGROUND. DNA fragments that appeared to belong to an unidentified human herpesvirus were recently found in more than 90 percent of Kaposi s sarcoma lesions associated with the acquired immunodeficiency syndrome (AIDS). These fragments were also found in 6 of 39 tissue samples without Kaposi s sarcoma, including 3 m


New viral footprints in Kaposi's sarcoma [editorial; comment]
N Engl J Med. 1995 May 4;332(18):1227-8. Unique Identifier : AIDSLINE MED/95214712
Roizman B
Crack cocaine and HIV in the inner city [letter]
N Engl J Med. 1995 May 4;332(18):1233-4. Unique Identifier : AIDSLINE MED/95214716
Fernando D
New York researchers question claims of 'first' AIDS case [news]
Nature. 1995 Mar 30;374(6521):397. Unique Identifier : AIDSLINE MED/95214731
Butler D
Human immunodeficiency virus. Protease uninhibited [news; comment]
Nature. 1995 Apr 6;374(6522):494. Unique Identifier : AIDSLINE MED/95214765
Richman DD
Was HIV present in 1959? [letter]
Nature. 1995 Apr 6;374(6522):503-4. Unique Identifier : AIDSLINE MED/95214770
Zhu T; Ho DD
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors [see comments]
Nature. 1995 Apr 6;374(6522):569-71. Unique Identifier : AIDSLINE MED/95214785
Condra JH; Schleif WA; Blahy OM; Gabryelski LJ; Graham DJ; Quintero JC; Rhodes A; Robbins HL; Roth E; Shivaprakash M; et al; Department of Antiviral Research, Merck Research Laboratories,; West Point, Pennsylvania 19486, USA.
Inhibitors of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic agents for HIV-1 infection. The clinical efficacy of HIV-1 reverse transcriptase inhibitors has been limited by the emergence of resistant viral variants. Similarly, variants expressing resistanc


[Peritoneal dialysis in cases of associated pathology]
Nephrologie. 1995;16(1):123-7. Unique Identifier : AIDSLINE MED/95214811
Labeeuw M; Caillette A; Denicola C; Diaz C; Unite de nephrologie et de traitement de l'insuffisance; renale, Hopital E. Herriot, Lyon.
There are two aspects to considerations of the value of peritoneal dialysis (PD) in the treatment of renal insufficiency with associated pathology. The first involves the effects of the treatment on the symptoms or evolution of the pathology. Examples include the improvement of dyspnea due to cardiac insufficiency (CI


[Conclusions elaborated by the jury after the consensus conference: peritoneal dialysis, method of treatment for chronic renal insufficiency]
Nephrologie. 1995;16(1):9-18. Unique Identifier : AIDSLINE MED/95214825
[Interleukin-6 (letter)]
Orv Hetil. 1995 Mar 12;136(11):634-5. Unique Identifier : AIDSLINE MED/95215052
Sinkovics J; Horak A
Abnormal B-cell function in HTLV-I-tax transgenic mice.
Oncogene. 1995 Mar 16;10(6):1045-51. Unique Identifier : AIDSLINE MED/95215062
Peebles RS; Maliszewski CR; Sato TA; Hanley-Hyde J; Maroulakou IG; Hunziker R; Schneck JP; Green JE; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21224.
Transgenic mice that carry the HTLV-I Tax gene develop an exocrinopathy with some similarities to Sjoegren s syndrome. Our experiments reveal that these mice have lymphadenopathy and splenomegaly composed primarily of B lymphocytes, as well as abnormal levels of secreted immunoglobulins. To gain insight into whether t


Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation.
Oncogene. 1995 Mar 16;10(6):1199-207. Unique Identifier : AIDSLINE MED/95215081
Suzuki T; Hirai H; Murakami T; Yoshida M; Department of Cellular and Molecular Biology, University of; Tokyo, Japan.
Tax protein of HTLV-1 stimulates transcription of specific cellular genes through the NF-kappa B binding site. We previously showed that Tax binds to the ankyrin motifs of I kappa B-gamma, and dissociates the I kappa B-gamma/NF-kappa B complexes, resulting in nuclear translocation of NF-kappa B proteins. We herein rep


Tonsil lymphoma presenting as tonsillitis after bone marrow transplantation.
Otolaryngol Head Neck Surg. 1995 Apr;112(4):544-8. Unique Identifier : AIDSLINE MED/95215096
Yellin SA; Weiss MH; Kraus DH; Papadopoulos EB; Department of Otolaryngology, Manhattan Eye, Ear and Throat; Hospital, New York, USA.
Bone marrow transplantation for the treatment of leukemia is increasingly successful in rendering patients disease free. However, it has become evident that the associated severe immunosuppression predisposes this population to an increased risk for other neoplastic disorders. We report on six patients in whom


Maternal-fetal interactions affect growth of human immunodeficiency virus type 1 transgenic mice.
Pediatr Res. 1995 Jan;37(1):56-63. Unique Identifier : AIDSLINE MED/95215173
Franks RR; Ray PE; Babbott CC; Bryant JL; Notkins AL; Santoro TJ; Klotman PE; Laboratory of Oral Medicine, National Institute of Dental; Research, National Institutes of Health, Bethesda, Maryland; 20892.
Infants vertically infected with human immunodeficiency virus type 1 (HIV-1) often manifest profoundly deficient growth with failure to thrive. The pathologic mechanisms that produce growth failure associated with pediatric HIV infection are not clear. Transgenic mice homozygous for a gag/pol deletion mutant of the in


A randomized, controlled trial of a school-based, multi-faceted AIDS education program in the elementary grades: the impact on comprehension, knowledge and fears.
Pediatrics. 1995 Apr;95(4):480-6. Unique Identifier : AIDSLINE MED/95215183
Schonfeld DJ; O'Hare LL; Perrin EC; Quackenbush M; Showalter DR; Cicchetti DV; Department of Pediatrics, Yale University School of Medicine, New; Haven, CT 06520-8064, USA.
OBJECTIVE: Several educational theorists have suggested that young children are unlikely to benefit from detailed instruction regarding AIDS prevention because of inherent developmental cognitive limitations. This study aims to determine whether AIDS education in the elementary grades can advance young children s unde


Who are the primary caretakers of children born to HIV-infected mothers? Results from a multistate surveillance project.
Pediatrics. 1995 Apr;95(4):511-5. Unique Identifier : AIDSLINE MED/95215189
Schable B; Diaz T; Chu SY; Caldwell MB; Conti L; Alston OM; Sorvillo F; Checko PJ; Hermann P; Davidson AJ; et al; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, GA 30333, USA.
OBJECTIVE. To determine the primary caretakers of children born to women with human immunodeficiency virus (HIV) infection. METHODS. We interviewed women at least 18 years of age who have been reported with HIV infection or acquired immunodeficiency syndrome to local health departments in 10 cities and states regardin


HIV/AIDS ward avoids closure [news]
Nurs Times. 1995 Mar 1-7;91(9):8. Unique Identifier : AIDSLINE MED/95215254
Molecular dynamics simulations of HIV-1 protease with peptide substrate.
Protein Eng. 1994 Nov;7(11):1353-63. Unique Identifier : AIDSLINE MED/95215341
Harrison RW; Weber IT; Department of Pharmacology, Jefferson Cancer Center, Thomas; Jefferson University, Philadelphia, PA 19107.
Molecular dynamics simulations of human immunodeficiency virus (HIV)-1 protease with a model substrate were used to test if there is a stable energy minimum for a proton that is equidistant from the four delta oxygen atoms of the two catalytic aspartic acids. The crystal structure of HIV-1 protease with a peptidic inh


Induction of feline acquired immune deficiency syndrome by feline leukemia virus: alteration in response to hormones in the hypothalamic-pituitary-gonadal system.
Proc Soc Exp Biol Med. 1995 Apr;208(4):404-12. Unique Identifier : AIDSLINE MED/95215365
Wang SW; Teng CS; Department of Anatomy, Physiological Sciences, and Radiology,; College of Veterinary Medicine, North Carolina State University,; Raleigh 27606.
Male kittens who were infected with the feline leukemia virus (FeLV) were found at various times after exposure to contain a sequence of dysfunction in their hypothalamic-pituitary-gonadal (HPG) system. To understand whether the involved endocrine glands in this system were damaged by FeLV, the hypothalamus, pituitary


Immunomagnetic CD8 depletion.
Prog Clin Biol Res. 1994;389:551-6. Unique Identifier : AIDSLINE MED/95215427
Jansen J; Hanks S; Akard L; Martin M; Ash R; Thompson J; English D; Bone Marrow Transplantation Program, Methodist Hospital of; Indiana, Indianapolis.
Electroencephalographic coherence in acquired immune deficiency syndrome.
Psychiatry Res. 1994 Oct;54(1):1-11. Unique Identifier : AIDSLINE MED/95215538
Newton TF; Leuchter AF; Walter DO; van Gorp WG; Morgenstern H; Miller EN; Lieb K; Visscher B; Satz P; Weiner H; Department of Psychiatry and Biobehavioral Sciences, UCLA, USA.
We studied a quantitative electroencephalographic (EEG) measure, coherence, in 28 patients with acquired immune deficiency syndrome (AIDS) and 56 uninfected volunteers. Compared with uninfected subjects, AIDS patients had increased coherence in the 6- to 10-Hz band. The largest increases in coherence were between fron


Reconstitution of SCID mice with low numbers of CD4+ TCR alpha beta + T cells.
Res Immunol. 1994 Jun;145(5):332-7. Unique Identifier : AIDSLINE MED/95215626
Reimann J; Rudolphi A; Claesson MH; Department of Bacteriology, University of Ulm, Germany.
Transfer of CD4+ T cells to C.B-17 SCID mice: a model to study Th1 and Th2 cell differentiation and regulation in vivo.
Res Immunol. 1994 Jun;145(5):347-53. Unique Identifier : AIDSLINE MED/95215629
Powrie F; Coffman RL; Correa-Oliveira R; DNAX Research Institute of Molecular and Cellular Biology Inc.,; Palo Alto, CA 94304, USA.
Modeling human retroviral pathogenesis and antiretroviral gene therapy in the SCID mouse.
Res Immunol. 1994 Jun;145(5):385-92. Unique Identifier : AIDSLINE MED/95215635
Chen IS; Zack JA; Department of Microbiology and Immunology, UCLA School of; Medicine, USA.
[Epidemiology and etiology of infectious diarrheas. The case of Mexico]
Rev Latinoam Microbiol. 1994 Oct-Dec;36(4):307-24. Unique Identifier : AIDSLINE MED/95215657
Valdespino-Gomez JL; Garcia-Garcia ML; Del Rio-Zolezzi A; Giono-Cerezo S; Salcedo-Alvarez RA; Sepulveda-Amor J; Instituto Nacional de Diagnostico y Referencia Epidemiologicos,; Mexico.
Gastrointestinal infections represent a health problem. It is estimated that 1647 million cases of diarrhea and 3.2 million deaths due to this cause occur among children less than five years of age per year. Those belonging to this age group have 15 times more risk of dying because of diarrhea. Cases of liquid acute d


A direct approach for correcting AIDS incidence: variance formula and comparison with other methods.
Stat Med. 1995 Jan 15;14(1):27-38. Unique Identifier : AIDSLINE MED/95215671
Alioum A; Commenges D; INSERM U.330, Universite de Bordeaux II, France.
We present a direct approach for correcting the acquired immunodeficiency syndrome (AIDS) incidence data for reporting delays, based on a non-parametric method for the analysis of right truncated data. We show that the proposed method when applied for grouped data is equivalent to three other published methods. We giv


[A case from practice (320). 1. Drug-induced fever. 2. HIV infection C3. multiple Kaposi sarcomas of the skin. Status after cerebral toxoplasmosis, PCP, herpes zoster. status after syphilis and gonorrhea]
Schweiz Rundsch Med Prax. 1995 Mar 21;84(12):353-4. Unique Identifier : AIDSLINE MED/95215691
Nuesch R; Departement fur Innere Medizin, Kantonsspital, Basel.
[Aspects of thoracic radiography of patients with tuberculosis and HIV infection in Ivory Coast]
Rev Pneumol Clin. 1994;50(6):317-22. Unique Identifier : AIDSLINE MED/95215728
N'Dhatz M; Domoua K; Coulibaly G; Traore F; Kanga K; Konan JB; Beugre LK; Doulhourou C; Yapi A; Service de Pneumophtisiologie, CHU de Treichville, Abidjan, Cote; d'Ivoire.
The aim of this prospective study was to investigate the main features of standard chest X-ray in patients with concomitant tuberculosis and HIV infection. From 21 December 1992 to 21 February 1993, we compared 45 chest X-rays of HIV+patients with pulmonary tuberculosis with those of 73 HIV negative patients with pulm


How to diagnose cobalamin deficiency.
Scand J Clin Lab Invest Suppl. 1994;219:61-76. Unique Identifier : AIDSLINE MED/95215762
Nexo E; Hansen M; Rasmussen K; Lindgren A; Grasbeck R; Dept Clinical Biochemistry, University Hospital of Aarhus,; Denmark.
Cobalamin deficiency must be suspected in all patients with unexplained neuropsychiatric symptoms or unexplained anemia. Special attention should be paid to patients at risk of developing cobalamin deficiency such as elderly people, vegetarians, HIV-infected patients, patients with gastrointestinal diseases and patien


Effectiveness of and compliance to preventive measures against the occupational transmission of human immunodeficiency virus.
Scand J Work Environ Health. 1994 Dec;20(6):393-400. Unique Identifier : AIDSLINE MED/95215803
Roy E; Robillard P; Centre for AIDS Studies, Montreal General Hospital, Canada.
To prevent the occupational transmission of human immunodeficiency virus (HIV) and other blood-borne infections in health care settings, guidelines have been issued as universal precautions and body substance isolation. Patient testing has also been advocated. The literature on the compliance to and effectiveness of t


Doubts cast on 1959 AIDS claim [news]
Science. 1995 Apr 7;268(5207):35. Unique Identifier : AIDSLINE MED/95215864
Education booster for AIDS [news]
Science. 1995 Apr 7;268(5207):35. Unique Identifier : AIDSLINE MED/95215865
Breastmilk, breastfeeding, and transmission of viruses to the neonate.
Semin Perinatol. 1994 Dec;18(6):510-6. Unique Identifier : AIDSLINE MED/95215879
Ruff AJ; Department of International Health, Johns Hopkins School of; Hygiene and Public Health, Baltimore, MD 21205.
The benefits of breast milk have been well delineated, and breastfeeding should be encouraged whenever possible. However, the potential transmission of HIV-1, HTLV-1, and possibly HTLV-II warrant the recommendation that women in industrialized countries who are infected with these viruses not breastfeed their infants.


Fighting the good fight. Lessons from Texas physicians.
Tex Med. 1995 Feb;91(2):34-9. Unique Identifier : AIDSLINE MED/95215969
Myers C
Non-tuberculous pulmonary infections in Scotland: a cluster in Lothian?
Thorax. 1995 Feb;50(2):188-90. Unique Identifier : AIDSLINE MED/95215990
Bollert FG; Watt B; Greening AP; Crompton GK; Respiratory Medicine Unit, Western General Hospital, Edinburgh,; UK.
BACKGROUND--A retrospective study was carried out to confirm the clinical impression that, in Lothian, non-tuberculous mycobacterial infections are as common as pulmonary tuberculosis. METHODS--All pulmonary isolates of Mycobacterium tuberculosis/bovis and non-tuberculous mycobacteria in Scotland from April 1990 to Ma


AIDS and the lung: update 1995. 1. Pneumocystis carinii pneumonia.
Thorax. 1995 Feb;50(2):191-200. Unique Identifier : AIDSLINE MED/95215991
Miller RF; Mitchell DM; Department of Medicine, University College London Medical School.
[Can HIV infection be treated with antioxidants?]
Tidsskr Nor Laegeforen. 1995 Mar 10;115(7):835-7. Unique Identifier : AIDSLINE MED/95216021
Muller F; Medisinsk avdeling A, Rikshospitalet, Oslo.
Several recent reports have indicated high levels of reactive oxygen species, causing oxidative stress, in the pathogenesis of HIV infection. Oxidative stress may lead to enhanced HIV replication in infected cells and may also aggravate the immunodeficiency by reduction of cellular immunity and possibly by increased p


Should patients with human immunodeficiency virus infection or chronic hepatitis donate blood for autologous use? [see comments]
Transfusion. 1995 Apr;35(4):324-30. Unique Identifier : AIDSLINE MED/95216082
Vanston V; Smith D; Eisenstaedt R; Department of Medicine, Abington Memorial Hospital, Pennsylvania,; USA.
BACKGROUND: The purpose of this project is to formally evaluate the benefits and the risks of allowing patients with human immunodeficiency virus (HIV) infection or hepatitis to donate blood for autologous use. STUDY DESIGN AND METHODS: With data on the incidence of transfusion-transmitted hepatitis B virus (HBV), hep


Procurement and transfusion of human immunodeficiency virus-positive or untested autologous blood units: issues and concerns: a report prepared by the Autologous Transfusion Committee of the American Association of Blood Banks.
Transfusion. 1995 Apr;35(4):353-61. Unique Identifier : AIDSLINE MED/95216087
Yomtovian R; Kelly C; Bracey AW; McCraney SK; Renner SW; Williamson KR; Attar S; Institute of Pathology, Case Western Reserve University,; Cleveland, Ohio, USA.
Haematological and lymphocyte subset analyses in sheep inoculated with bovine immunodeficiency-like virus.
Vet Res Commun. 1994;18(6):471-82. Unique Identifier : AIDSLINE MED/95216331
Jacobs RM; Smith HE; Whetstone CA; Suarez DL; Jefferson B; Valli VE; Department of Pathology, University of Guelph, Ontario, Canada.
Bovine immunodeficiency-like virus (BIV) was passaged in vivo by intraperitoneal transfusion of ovine whole blood. Prior to transfusion, the recipient sheep were given sodium thioglycolate intraperitoneally to induce mild non-suppurative inflammation. The anti-BIV antibody response, haematology, and peripheral blood l


Blood safety in developing countries.
Vox Sang. 1994;67(4):377-81. Unique Identifier : AIDSLINE MED/95216360
Gibbs WN; Corcoran P; Unit of Health Laboratory Technology and Blood Safety, World; Health Organization, Geneva, Switzerland.
This study, based on responses to a questionnaire, was undertaken to define problems in and formulate solutions for improving blood safety in developing countries as part of an effort to monitor the status of blood transfusion services globally. Despite improvements between 1988 and 1992, only 66% of developing countr


Detection of HIV-1 by RNA PCR in factor VIII concentrates [letter]
Vox Sang. 1994;67(4):402-3. Unique Identifier : AIDSLINE MED/95216364
Heredia A; Guo ZP; Yu MW; Mason BL; Epstein JS; Hewlett IK
Anti-HIV screening of blood donors [letter]
Vox Sang. 1994;67(4):404. Unique Identifier : AIDSLINE MED/95216365
Cavalli P; Tanzi E; Villa D; Bedoschi D; Zanetti A
Seroprevalence of HTLV-I/HTLV-II in blood donors in Buenos Aires (Argentina) [letter]
Vox Sang. 1994;67(4):408-9. Unique Identifier : AIDSLINE MED/95216368
Gutfraind Z; Blejer JL; Saguier MC; Gomez Carretero ML; Pirola DA; Carreras Vescio LA
HIV-1 causing AIDS and death in a seronegative individual [letter]
Vox Sang. 1994;67(4):410-1. Unique Identifier : AIDSLINE MED/95216369
Soriano V; Dronda F; Gonzalez-Lopez A; Chaves F; Bravo R; Gutierrez M; Heredia A; Hewlett I
Formic acid in the control of varroatosis: a practical approach.
Zentralbl Veterinarmed [B]. 1994 Oct;41(7-8):433-40. Unique Identifier : AIDSLINE MED/95216407
Mutinelli F; Cremasco S; Irsara A; Istituto Zooprofilattico Sperimentale delle Venezie, Padova,; Italy.
To evaluate the applicability of formic acid in the control of varroatosis, a trial on 55 hives was carried out during the second half of August. Into the moving base of the hive were inserted 60% formic-acid-soaked pads. The treatment was administered according to two different schedules: weekly treatment for 4 weeks


The histological and immunohistochemical pattern of positive patch test reactions to gold sodium thiosulfate.
Acta Derm Venereol. 1994 Nov;74(6):417-23. Unique Identifier : AIDSLINE MED/95216423
Moller H; Larsson A; Bjorkner B; Bruze M; Department of Dermatology, Lund University, Malmo, Sweden.
Gold sodium thiosulfate, inserted in the patch test standard series, gives a surprisingly high yield of positive reactions, about 10% of tested eczema patients, but with a low degree of clinical relevance. A histopathological study on patch test reactions was carried out in patients selected because of a combined cont


Human papillomavirus type 16-associated periungual squamous cell carcinoma in a patient with acquired immunodeficiency syndrome [letter]
Acta Derm Venereol. 1994 Nov;74(6):478-9. Unique Identifier : AIDSLINE MED/95216445
Tosti A; La Placa M; Fanti PA; Gentilomi G; Venturoli S; Zerbini M; Musiani M
Hemopoietic recovery from AZT toxicity with recombinant hemoglobin in a murine model of AIDS.
Acta Haematol. 1994;92(4):182-6. Unique Identifier : AIDSLINE MED/95216470
Moqattash S; Lutton JD; Abu-Hijleh MF; Abraham NG; Department of Human and Clinical Anatomy, Sultan Qaboos; University, Muscat, Sultanate of Oman.
We studied the toxic effects of azidothymidine ( AZT ) on the hemopoietic colony growth (CFU-E, BFU-E and CFU-GM) of bone marrow in a murine model of AIDS (MAIDS). A sparing effect by recombinant hemoglobin (r-Hb) on AZT suppression of MAIDS bone marrow


Leukocyte differentiation antigens in the bone marrow of patients with HIV-related disease.
Acta Haematol. 1994;92(4):197-203. Unique Identifier : AIDSLINE MED/95216473
von Laer D; Modrau B; Dietrich M; Kern P; Clinical Department, Bernhard Nocht Institute for Tropical; Medicine, Hamburg, Germany.
To understand at what level hematopoiesis is impaired in AIDS patients, we quantitated bone marrow cells of the myeloid and lymphoid lineages in their different stages of differentiation. The bone marrow aspirates of 20 HIV-infected patients (18 with CDC IV) and 11 controls were analyzed by flow cytometry, using a pan


Current report--HIV. Antiretroviral strategies revisited.
J Am Board Fam Pract. 1995 Jan-Feb;8(1):62-9. Unique Identifier : AIDSLINE MED/95216524
Goldschmidt RH; Dong BJ; Legg JJ; Family Practice Residency Program, San Francisco General; Hospital, CA 94110, USA.
Whole-body protein turnover from leucine kinetics and the response to nutrition in human immunodeficiency virus infection.
Am J Clin Nutr. 1995 Apr;61(4):818-26. Unique Identifier : AIDSLINE MED/95216588
Macallan DC; McNurlan MA; Milne E; Calder AG; Garlick PJ; Griffin GE; Department of Cellular and Molecular Sciences, St George's; Hospital Medical School, London, UK.
Whole-body protein metabolism was investigated in human immunodeficiency virus (HIV) infection by primed constant infusion of L-[1-13C]leucine in 8 control and 22 HIV-infected subjects (8 stage II; 14 stage IV disease), in postabsorptive and fed states. Postabsorptive leucine flux was increased 25% in subjects with st


CD4+ T-cell number at the time of acquired immunodeficiency syndrome.
Am J Epidemiol. 1995 Apr 1;141(7):645-51. Unique Identifier : AIDSLINE MED/95216602
Taylor JM; Sy JP; Visscher B; Giorgi JV; Department of Biostatistics, University of California, Los; Angeles.
In this article, the authors adapt and extend the methodology of Phillips (Phillips et al. J Acquir Immune Defic Syndr 1992;5:148-52) to estimate the distribution of CD4+ T-cell number at the time of acquired immunodeficiency syndrome (AIDS) and to estimate the correlation between CD4+ T-cell number at AIDS and CD4+ T


Changing patterns of Kaposi's sarcoma in Danish acquired immunodeficiency syndrome patients with complete follow-up. The Danish Study Group for HIV Infection (DASHI).
Am J Epidemiol. 1995 Apr 1;141(7):652-8. Unique Identifier : AIDSLINE MED/95216603
Lundgren JD; Melbye M; Pedersen C; Rosenberg PS; Gerstoft J; Department of Infectious Diseases (Unit 144), Hvidovre Hospital,; Denmark.
The objective was to study changes in the occurrence of human immunodeficiency virus type 1-related Kaposi s sarcoma and the association with degree of immunodeficiency over time. Danish patients with acquired immunodeficiency syndrome (AIDS) diagnosed between 1979 and 1990 (n = 687) were followed clinically and with


The under-enrollment of HIV-infected foster children in clinical trials and protocols and the need for corrective state action.
Am J Law Med. 1994;20(3):231-49. Unique Identifier : AIDSLINE MED/95216636
McNutt B; New York University School of Law, USA.
Civil rights: pregnancy discrimination--Armstrong v. Flowers.
Am J Law Med. 1994;20(3):345-6. Unique Identifier : AIDSLINE MED/95216641
Pediatric HIV infection in Elista, Russia: interventional strategies [news]
Am J Public Health. 1995 Apr;85(4):586-8. Unique Identifier : AIDSLINE MED/95216695
Mintz M; Boland M; O'Hara MJ; Barros J; Hansen C; Denny TN; Scolpino A; Maha-Elkins M; Sandzhieva D; Esenova V; et al
The role of gender relations in HIV prevention research for women [letter; comment]
Am J Public Health. 1995 Apr;85(4):592. Unique Identifier : AIDSLINE MED/95216699
Wingood GM; DiClemente RJ
Screening surgeons for HIV infection. A cost-effectiveness analysis [see comments]
Ann Intern Med. 1995 May 1;122(9):641-52. Unique Identifier : AIDSLINE MED/95216792
Owens DK; Harris RA; Scott PM; Nease RF Jr; Department of Veterans Affairs Medical Center, Palo Alto,; California, USA.
OBJECTIVE. To determine the cost-effectiveness of a policy to screen surgeons for human immunodeficiency virus (HIV) infection to prevent transmission of HIV to patients having invasive procedures. DESIGN: Cost-effectiveness analysis. RESULTS: A one-time national screening program would identify approximately 137 surg


Prophylaxis for opportunistic infections [letter; comment]
Ann Intern Med. 1995 May 1;122(9):730-1. Unique Identifier : AIDSLINE MED/95216807
Albrecht H; Stellbrink HJ
[Preservation of cutaneous structures of egyptian mummies. An ultrastructural study]
Ann Dermatol Venereol. 1994;121(6-7):470-5. Unique Identifier : AIDSLINE MED/95216847
Perrin C; Noly V; Mourer R; Schmitt D; INSERM U346 Peau humaine et Immunite, Clinique Dermatologique,; Hopital Edouard-Herriot, Lyon.
INTRODUCTION. The recent development of studies applied to ancient materials may be explained by the application of molecular biology techniques on the extracted ancient DNA mainly the polymerase chain reaction (PCR), the ultrasensitive DNA-amplification technique that hit the headlines in the late 1980s. PCR was used


[Monthly question. Should prophylaxis of pneumocystis carinii pneumonia be done in patients with inflammatory skin diseases treated by corticosteroids and/or immunosuppressive agents?]
Ann Dermatol Venereol. 1994;121(6-7):515-8. Unique Identifier : AIDSLINE MED/95216859
[Pulmonary hypertension caused by talcoma in a couple of drug addicts]
Ann Cardiol Angeiol (Paris). 1995 Jan;44(1):14-5. Unique Identifier : AIDSLINE MED/95216921
Ferrari E; Drai E; Taillan B; Talbodec A; Baudouy M; Morand P; Service de Cardiologie, Hopital Pasteur, Nice.
The authors report a case of severe pulmonary hypertension (PHT) in a couple of HIV seropositive heroin addicts. The parallel clinical course in these two patients with only mild immunodeficiency and the fact that they both had the same supplier were in favour of PHT secondary to talcoma. In the light of these cases,


Oligoclonal proliferation of human T-cell leukemia virus type I infected lymphocytes in lesions of virus-induced arthropathy.
Biochem Biophys Res Commun. 1995 Mar 28;208(3):1040-5. Unique Identifier : AIDSLINE MED/95217185
Yamamoto K; Aono H; Nakajima T; Hasunuma T; Nishioka K; Division of Rheumatology and Molecular Immunology, St. Marianna; University School of Medicine, Kawasaki, Japan.
To investigate the pathogenesis of human T-cell leukemia virus type I associated arthropathy, the mode of proviral integration in the pathological lesions was analyzed using ligation-mediated polymerase chain reaction. Peripheral blood mononuclear cells (PBMC) of these patients possessed multiple dominant clones of th


Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T-lymphoblastoid cells.
Biochem Pharmacol. 1995 Mar 15;49(6):829-37. Unique Identifier : AIDSLINE MED/95217229
Tornevik Y; Ullman B; Balzarini J; Wahren B; Eriksson S; Department of Medical Biochemistry and Biophysics, Karolinska; Institute, Stockholm, Sweden.
Activation of the anti-human immunodeficiency virus (HIV) compound 3 -azido-3 -deoxythymidine ( AZT ) is dependent on its 5 -phosphorylation by cellular nucleoside and nucleotide kinases. Azidothymidine 5 -triphosphate (AZTTP) is considered to be the me


[Lymph node tuberculosis in HIV-1 seropositive patients in Central Africa. A characteristic histopathologic picture]
Ann Pathol. 1995;15(1):38-44. Unique Identifier : AIDSLINE MED/95217236
Ngilimana PJ; Metz T; Munyantore S; Mureganshuro JM; Noel H; Roels H; Faculte de Medecine, Universite Nationale du Rwanda, Butare.
Sixty two patients fulfilling the definition established by the Centers for Disease Control in 1982 for persistent lymphadenopathy syndrome, thought to be related to the human immunodeficiency virus (HIV) infection, were selected at the Butare university hospital, in Rwanda , betwee


[Cassenne Laboratories immunology meetings]
Allerg Immunol (Paris). 1994 Dec;26(10):388-9. Unique Identifier : AIDSLINE MED/95217308
Roucher C; Laboratoire d'Immuno-Allergologie-CHU, Angers.
Distinction between HIV-1 and HIV-2 nucleotide sequences by PCR and restriction enzyme analysis.
Biotechniques. 1995 Jan;18(1):20, 22, 24. Unique Identifier : AIDSLINE MED/95217446
Sidhu MK; Rashidbaigi A; Liao MJ; Testa D; Interferon Sciences, Inc., New Brunswick, NJ 08901-3605.
[Preliminary results of radiotherapy-chemotherapy combination in the treatment of African Kaposi sarcoma]
Bull Cancer Radiother. 1994;81(2):151-3. Unique Identifier : AIDSLINE MED/95217529
Mouele-Sone A; Ngbangako MC; Ashu AE; Ngwane S; Hopital general de Douala, Cameroun.
[Cancers associated with AIDS (editorial)]
Bull Cancer Radiother. 1995;82(1):3-8. Unique Identifier : AIDSLINE MED/95217570
Piedbois P; Frikha H; Le Bourgeois JP
The acquired immunodeficiency syndrome (AIDS) defining conditions were expanded to include three malignancies: epidemic Kaposi s sarcoma recognized in 1981, high and intermediate grade lymphoma included in 1985 and cervical carcinoma considered since January 1993. Progression in the management of these neoplasms depen


The distribution of erosion in the dentitions of patients with eating disorders [see comments]
Br Dent J. 1995 Mar 11;178(5):171-5. Unique Identifier : AIDSLINE MED/95217585
Robb ND; Smith BG; Geidrys-Leeper E; Department of Restorative Dentistry, Dental School, Newcastle; upon Tyne.
Anorexia and bulimia nervosa (the eating disorders) are potentially life threatening and are becoming more prevalent. This paper reviews the effects of these disorders on dental erosion and reports a study to assess the effects of the eating disorders on the erosion of teeth relating the severity of erosion to factors


It'll never happen to me: gay men's beliefs, perceptions and folk constructions of sexual risk.
AIDS Educ Prev. 1994 Dec;6(6):467-82. Unique Identifier : AIDSLINE MED/95217599
Lowy E; Ross MW; National Centre in HIV Social Research, University of New South; Wales, Sydney, Australia.
This article reports on homosexually active men s beliefs about being at sexual risk. Results were generated from paid, in-depth, face-to-face interviews about sexual behavior carried out first with 4 pilot respondents, then with 21 gay respondents aged 18-39, half of whom were HIV seropositive. Findings suggest that


Psychosocial factors associated with risky sexual behavior among HIV-seropositive gay men.
AIDS Educ Prev. 1994 Dec;6(6):483-92. Unique Identifier : AIDSLINE MED/95217600
Robins AG; Dew MA; Davidson S; Penkower L; Becker JT; Kingsley L; Department of Psychiatry, University of Pittsburgh School of; Medicine, PA 15213.
The present study examines sociodemographic characteristics, levels of psychological distress, and coping styles among HIV-seropositive (HIV+) gay men who either did or did not engage in sexual activity which placed others at risk for HIV infection. Risky sexual behavior was defined as engaging in insertive anal inter


Behavioral risk-reduction strategies to prevent HIV infection among homosexual men: a grounded theory approach.
AIDS Educ Prev. 1994 Dec;6(6):493-505. Unique Identifier : AIDSLINE MED/95217601
de Wit JB; Teunis N; van Griensven GJ; Sandfort TG; Department of Gay and Lesbian Studies, Utrecht University, The; Netherlands.
To be able to design effective health education interventions for homosexual men, it is necessary to understand determinants of safe and unsafe sex from the perspective of those involved. In this qualitative study, therefore, an open approach was taken to allow for this perspective. Interviews were conducted with 50 r


Social support and sexual risk taking among women on methadone.
AIDS Educ Prev. 1994 Dec;6(6):506-13. Unique Identifier : AIDSLINE MED/95217602
el-Bassel N; Schilling RF; Columbia University School of Social Work, New York, NY 10025.
This study examines the social support network of 109 female methadone patients and explores the relationship between social support and background variables, attitudes toward safer sex and sexual risk behavior. Subjects reported small supportive networks consisting primarily of drug users. Women who felt more loved b


HIV-risk behavior among lesbians and bisexual women.
AIDS Educ Prev. 1994 Dec;6(6):514-23. Unique Identifier : AIDSLINE MED/95217603
Einhorn L; Polgar M; Sociology Department, University of Pennsylvania, Philadelphia; 19104-6299.
Although limited available data suggest that AIDS is currently less common among lesbians than among heterosexual women, this study suggests considerable HIV-risk behavior among our sample of lesbians and bisexual women. In addition, a majority of respondents, including women at risk, do not use safer-sex practices.


Scale reliability and construct validity: a pilot study among primary school children in Northern Tanzania.
AIDS Educ Prev. 1994 Dec;6(6):524-34. Unique Identifier : AIDSLINE MED/95217604
Seha AM; Klepp KI; Ndeki SS; Tanzanian-Norwegian AIDS Project (MUTAN), Moshi, Tanzania.
Based on the World Health Organization s standardized survey inventories assessing AIDS-related knowledge, attitudes, beliefs, and practices (KABP) for adolescents, a written questionnaire was developed and pilot tested among primary school children in Northern Tanzania . Subjects


Attitudes of baccalaureate nursing students in one school toward acquired immune deficiency syndrome.
AIDS Educ Prev. 1994 Dec;6(6):535-41. Unique Identifier : AIDSLINE MED/95217605
Bowman JM; Brown ST; Eason FR; School of Nursing, East Carolina University, Greenville, NC; 27858-4353.
The purpose of this descriptive study was to gather information about the attitudes of nursing students toward Acquired Immune Deficiency Syndrome (AIDS) and to determine if there was a relationship between demographic variables and the attitudes expressed. In this study the AIDS Attitude Scale developed by Shrum, Tur


Magic Johnson and public attitudes toward AIDS: a review of empirical findings.
AIDS Educ Prev. 1994 Dec;6(6):542-57. Unique Identifier : AIDSLINE MED/95217606
Kalichman SC; Center for AIDS Intervention Research (CAIR) Medical College of; Wisconsin, Milwaukee 53226.
The public announcement of HIV seropositivity and early professional retirement of basketball star Earvin Magic Johnson acted as a naturalistic experimental manipulation of media representations of persons living with HIV infection. This article reviews empirical studies of psychological and behavioral changes that oc


The first London-based Brook Advisory centre to include a screening service for sexually transmitted disease [news]
Nurs Stand. 1995 Feb 1-7;9(19):11. Unique Identifier : AIDSLINE MED/95217720
Does HIV replicate rapidly from the start? [news]
Nurs Stand. 1995 Feb 1-7;9(19):14. Unique Identifier : AIDSLINE MED/95217721
Aldhous P
Nurses 'vital' in halting spread of HIV among prisoners [news]
Nurs Stand. 1995 Feb 15-21;9(21):7. Unique Identifier : AIDSLINE MED/95217770
Media watch: out in the cold.
Nurs Stand. 1995 Feb 22-28;9(22):46. Unique Identifier : AIDSLINE MED/95217785
Lowe H
Fear of contracting AIDS falls in Britain [news]
Nurs Stand. 1995 Feb 22-28;9(22):9. Unique Identifier : AIDSLINE MED/95217791
Immunodeficiency and new treatment for HBV [news]
Nurs Stand. 1995 Mar 1-7;9(23):14. Unique Identifier : AIDSLINE MED/95217792
Benhamou Y
Increased number of circulating HTLV-1 infected cells in peripheral blood mononuclear cells of HTLV-1 uveitis patients: a quantitative polymerase chain reaction study [published erratum appears in Br J Ophthalmol 1995 Jun;69(6):621]
Br J Ophthalmol. 1995 Mar;79(3):270-6. Unique Identifier : AIDSLINE MED/95217861
Ono A; Mochizuki M; Yamaguchi K; Miyata N; Watanabe T; Department of Pathology, University of Tokyo, Japan.
AIMS--This study aimed to characterise the status of viral infection in patients with HTLV-1 uveitis (HU) by quantifying the circulating HTLV-1 infected cells in the peripheral blood. METHODS--Genomic DNA samples of peripheral blood mononuclear cells (PBMC) were obtained from 25 patients with HU, 14 patients with trop


Variation in the expression of human immunodeficiency virus RNA and cytokine mRNA in rectal mucosa during the progression of infection.
Lymphokine Cytokine Res. 1994 Dec;13(6):391-8. Unique Identifier : AIDSLINE MED/95217974
Reka S; Garro ML; Kotler DP; Department of Medicine, St. Luke's-Roosevelt Hospital Center,; College of Physicians and Surgeons, Columbia University, New; York.
Previous studies demonstrated that mucosal HIV p24 antigen content varied during the progression of HIV infection. In this study, expression of HIV RNA and mRNA of selected cytokines was examined in rectal mucosa from HIV-infected individuals. Rectal biopsies from 27 subjects were studied: 7 with CD4 counts > 500/mm3


Blocking cell microtubule assembly inhibits the alloimmune response in vitro and prolongs renal allograft survival by inhibition of Th1 and sparing of Th2 cell function in vivo.
J Am Soc Nephrol. 1995 Jan;5(7):1418-25. Unique Identifier : AIDSLINE MED/95218051
Akalin E; Hancock WW; Perico N; Remuzzi G; Imberti O; Carpenter CB; Sayegh MH; Department of Medicine, Brigham and Women's Hospital, Harvard; Medical School, Boston, MA 02115.
Colchicine inhibits cell microtubule assembly by binding to and preventing the polymerization of tubulin monomers. Although there are data to indicate that colchicine inhibits a variety of cell-mediated immune responses, the effects and mechanisms of inhibiting cell microtubule assembly on the alloimmune response have


Elevated serum levels of soluble CD23 (sCD23) precede the appearance ofacquired immunodeficiency syndrome--associated non-Hodgkin's lymphoma.
Blood. 1995 Apr 1;85(7):1843-9. Unique Identifier : AIDSLINE MED/95218184
Yawetz S; Cumberland WG; van der Meyden M; Martinez-Maza O; Department of Microbiology & Immunology, Jonsson Comprehensive; Cancer Center, UCLA School of Medicine 90095-1747, USA.
Human immunodeficiency virus (HIV) infection-associated B-cell hyperstimulation, in particular, the chronic stimulation of B cells to undergo isotype switching, may play an important role in the pathogenesis of acquired immunodeficiency syndrome-associated lymphoma (AIDS lymphoma). Isotype switching can be induced by


Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells.
Blood. 1995 Apr 1;85(7):1865-70. Unique Identifier : AIDSLINE MED/95218187
Furukawa Y; Osame M; Kubota R; Tara M; Yoshida M; Department of Cellular and Molecular Biology, University of; Tokyo, Japan.
Patients with human T-cell leukemia virus type-1 (HTLV-1)-associated myelopathy (HAM/TSP) generally harbor a much greater population of HTLV-1-infected T cells in peripheral blood mononuclear cells (PBMCs) than asymptomatic carriers. These cells are not malignant but frequently proliferate clonally. To investigate the


The skeleton in the hospital closet--20 years later: malnutrition in patients with GI disease, cancer and AIDS.
Nutrition. 1994 Nov-Dec;10(6):569-71. Unique Identifier : AIDSLINE MED/95218352
Laviano A; Campos AC; Department of Surgery, SUNY Health Science Center, Syracuse.
A comparison of the determinants of safe injecting and condom use among injecting drug users.
Addiction. 1995 Feb;90(2):217-26. Unique Identifier : AIDSLINE MED/95218585
Myers T; Millson M; Rigby J; Ennis M; Rankin J; Mindell W; Strathdee S; HIV Social, Behavioural and Epidemiological Studies Unit,; Department of Health Administration, Toronto, Ontario, Canada.
A sample of 582 injecting drug users were interviewed as part of an evaluation of an AIDS prevention programme for drug users. This paper examines the biographic and predispositional determinants of five HIV preventive behaviours--equipment sharing (not receiving and not giving) and and condom use (with regular partne


The Zurich experience is not an argument against harm reduction policy [letter; comment]
Addiction. 1995 Feb;90(2):291-2. Unique Identifier : AIDSLINE MED/95218593
Hausser D; Kuebler D
A needle exchange for Santos [news]
Addiction. 1995 Feb;90(2):295-6. Unique Identifier : AIDSLINE MED/95218596
AIDS in Brazil [news]
Addiction. 1995 Feb;90(2):296-7. Unique Identifier : AIDSLINE MED/95218597
Non-governmental organizations [news]
Addiction. 1995 Feb;90(2):297. Unique Identifier : AIDSLINE MED/95218598
Immunomodulation in choroidal melanoma: reversal of inverted CD4/CD8 ratios following treatment with ultrasonic hyperthermia.
Biotechnol Ther. 1994;5(1-2):59-68. Unique Identifier : AIDSLINE MED/95218615
Rosberger DF; Coleman DJ; Silverman R; Woods S; Rondeau M; Cunningham-Rundles S; Department of Ophthalmology, Cornell University Medical College,; New York, New York, USA.
It has long been suggested that malignant melanomas, cutaneous as well as uveal, are responsive to human immune-mediated host defenses. We report here 5 consecutive cases of posterior choroidal melanomas which were treated with hyperthermia generated by high-intensity focused ultrasound. Patient immune function was mo


Preparation of anti-HIV-low-density lipoprotein complexes for delivery of anti-HIV drugs via the low-density lipoprotein pathways.
Biotechnol Ther. 1994;5(1-2):69-85. Unique Identifier : AIDSLINE MED/95218616
Sqalli-Houssaini H; Pierlot C; Kusnierz JP; Parmentier B; Martin-Nizard F; Lestavel-Delattre S; Tartar A; Fruchart JC; Sergheraert C; Duriez P; Pasteur Institute, INSERM U325, Lille, France.
Lipophilic prodrugs of 3 -azido-3 -deoxythymidine ( AZT ) and of 2 ,3 -didehydro-3 -deoxythymidine (D4T) have been synthesized. 3 beta-(2 -carboxymethoxy)-cholest-5-ene acid, palmitic acid, linolenic acid, linoleic acid, and cholanic acid have been cova


A structural comparison of 21 inhibitor complexes of the aspartic proteinase from Endothia parasitica.
Protein Sci. 1994 Nov;3(11):2129-43. Unique Identifier : AIDSLINE MED/95218643
Bailey D; Cooper JB; Department of Crystallography, Birkbeck College, University of; London, United Kingdom.
The aspartic proteinases are an important family of enzymes associated with several pathological conditions such as hypertension (renin), gastric ulcers (pepsin), neoplastic disease (cathepsins D and E), and AIDS (HIV proteinase). Studies of inhibitor binding are therefore of great importance for design of novel inhib


Self-caring in a family unit of an HIV-positive individual: a hermeneutical inquiry.
Clin Nurs Res. 1994 Nov;3(4):334-52. Unique Identifier : AIDSLINE MED/95218652
Saunders JM
The purpose of this longitudinal, qualitative study is to understand self-caring in the context of the spectrum of Human Immunodeficiency Virus (HIV) disease. This article presents the personal perspective of one family affected by HIV disease. The findings are presented through discussing a pattern of self-caring, be


Circulating activated T lymphocyte subsets in patients with silent thyroiditis.
Endocr J. 1994 Dec;41(6):663-9. Unique Identifier : AIDSLINE MED/95218899
Kushima K; Ban Y; Taniyama M; Itoh K; 3rd Department of Internal Medicine, Showa University School of; Medicine, Tokyo, Japan.
In order to investigate the immunological aspects of silent thyroiditis, T lymphocyte subsets were analyzed by two-color flow cytometry in 10 patients with silent thyroiditis in the thyrotoxic phase, 12 patients with silent thyroiditis in the recovery phase, and 11 healthy volunteers as a control. The percentages of C


Clinical preventive services efficacy and adolescents' risky behaviors.
Arch Pediatr Adolesc Med. 1995 Apr;149(4):374-9. Unique Identifier : AIDSLINE MED/95218987
Downs SM; Klein JD; Department of Pediatrics, University of North Carolina School of; Medicine, Chapel Hill, USA.
OBJECTIVE/BACKGROUND: To analyze the value of studying or implementing office-based clinical preventive services for adolescents. Most adolescent mortality and morbidity is attributable to risky behaviors, yet clinical preventive services to reduce risky behaviors are often challenged because their efficacy has not be


New AIDS/HIV group [news]
Aust Nurs J. 1995 Feb;2(7):7. Unique Identifier : AIDSLINE MED/95219053
HIV/AIDS group [news]
Aust Nurs J. 1995 Mar;2(8):6. Unique Identifier : AIDSLINE MED/95219062
HIV/AIDS--knowledge, attitudes and education of nurses: a review of the research.
J Clin Nurs. 1995 Jan;4(1):13-21. Unique Identifier : AIDSLINE MED/95219220
Tierney AJ
This paper provides a review of research relating to knowledge, attitudes and education of nurses in relation to HIV/AIDS. Early studies portrayed nurses (and other health-care workers) as fearful of AIDS, ill-informed, and negative and discriminatory in their attitudes towards people with HIV/AIDS. Several major surv


Absence of exogenous retroviruses in Felty's syndrome [letter]
Br J Rheumatol. 1995 Feb;34(2):185-7. Unique Identifier : AIDSLINE MED/95219324
Nelson PN; Bowman SJ; Hay FC; Lanchbury JS; Panayi GS; Lever AM
Vaccines against HIV [editorial]
QJM. 1995 Feb;88(2):77-9. Unique Identifier : AIDSLINE MED/95219431
Carmichael AJ; Sissons JG
AIDS. A problem of antigen presentation?
Curr Biol. 1994 Dec 1;4(12):1131-4. Unique Identifier : AIDSLINE MED/95219446
Knight SC; Antigen Presentation Research Group, St Mary's Hospital Medical; School, Northwick Park Hospital, Harrow, UK.
Evidence is accumulating that antigen-presenting dendritic cells--both those that activate T cells and those that interact with B cells--may be involved in the development of immunodeficiency during HIV-1 infection.


Estimates for different stages of HIV/AIDS disease.
Comput Appl Biosci. 1994 Dec;10(6):681-3. Unique Identifier : AIDSLINE MED/95219577
Wilson SR; Solomon PJ; Centre for Mathematics and its Applications, Australian National; University, Canberra.
Software for estimating current and future numbers in different stages of the natural history of HIV infection has been developed. This is based on a general multistage model for the natural history of HIV/AIDS disease, allowing for treatment effects. The multistage model has been incorporated into the general back-pr


Status of endocrine disease with HIV infection.
Curr Ther Endocrinol Metab. 1994;5:190-4. Unique Identifier : AIDSLINE MED/95219621
Donovan DS Jr; Dluhy RG; Harvard Medical School, Boston, Massachusetts.
Changing behaviors [comment]
Clin Nurse Spec. 1994 Nov;8(6):320. Unique Identifier : AIDSLINE MED/95219807
Forbes KE
Families as a source of AIDS information for school age children [see comments]
Clin Nurse Spec. 1994 Nov;8(6):321-7. Unique Identifier : AIDSLINE MED/95219808
Player ML; Frank DI
The acquired immune deficiency syndrome (AIDS) pandemic, which has taken an increasingly devastating toll worldwide over the past 10 years, has highlighted the need for carefully designed, massive public education campaigns focused on prevention. Research has shown that education will be most effective if it occurs be


Endemic mycoses in AIDS: a clinical review.
Clin Microbiol Rev. 1995 Jan;8(1):146-59. Unique Identifier : AIDSLINE MED/95219827
Wheat J; Department of Medicine, Roudebush Department of Veterans Affairs; Hospital, Indianapolis, Indiana.
Histoplasmosis and coccidioidomycosis are serious opportunistic infections in patients with AIDS who reside in areas of endemicity of the United States and Central and South America. Blastomycosis, although less common, also must be r


Feline immunodeficiency virus: an interesting model for AIDS studies and an important cat pathogen.
Clin Microbiol Rev. 1995 Jan;8(1):87-112. Unique Identifier : AIDSLINE MED/95219831
Bendinelli M; Pistello M; Lombardi S; Poli A; Garzelli C; Matteucci D; Ceccherini-Nelli L; Malvaldi G; Tozzini F; Department of Biomedicine, University of Pisa, Italy.
The lentivirus feline immunodeficiency virus (FIV) is a widespread pathogen of the domestic cat that is mainly transmitted through bites, although other means of transmission are also possible. Its prevalence ranges from 1 to 10% in different cat populations throughout the world, thus representing a large reservoir of


Susceptibility to mercuric chloride-induced glomerulonephritis is age-dependent: study of the role of IFN-gamma.
Cell Immunol. 1995 Apr 15;162(1):131-7. Unique Identifier : AIDSLINE MED/95219836
van der Meide PH; Groenestein RJ; de Labie MC; Aten J; Weening JJ; Biomedical Primate Research Centre (BPRC) TNO, Rijswijk, The; Netherlands.
The repeated administration of low-dose HgCl2 to brown Norway (BN) rats induces an autoimmune syndrome which is characterized by polyclonal B cell activation, high-level synthesis of IgE and IgG1, and massive proteinuria. Data have been presented suggesting that during disease deve


Enhanced T cell maturation and altered lineage commitment in T cell receptor/CD4-transgenic mice.
Cell Immunol. 1995 Apr 15;162(1):56-67. Unique Identifier : AIDSLINE MED/95219846
Lieberman SA; Spain LM; Wang L; Berg LJ; Department of Molecular and Cellular Biology, Harvard University,; Cambridge, Massachusetts 02138, USA.
The two mature subsets of T lymphocytes, CD4+ and CD8+ cells arise from a common progenitor during development in the thymus. The differentiation of this progenitor cell into one of the two mature T cell subsets is determined by the specificity of the alpha beta TCR for MHC class I or class II molecules. Using a line


Safety, effectiveness and ease of use of a non-reusable syringe in a developing country immunization programme.
Bull World Health Organ. 1995;73(1):57-63. Unique Identifier : AIDSLINE MED/95219862
Steinglass R; Boyd D; Grabowsky M; Laghari AG; Khan MA; Qavi A; Evans P; Resources for Child Health (REACH) (John Snow, Inc.), Arlington,; VA 22209, USA.
Unsterile needles and syringes may transmit blood-borne infectious agents such as HIV and hepatitis B virus. The emergence of these diseases as major public health concerns and the risk of nosocomial transmission has heightened interest in the development of single-use injection devices. WHO and UNICEF embarked on a p


Urinary selenium concentrations in heroin abusers.
Clin Chim Acta. 1994 Nov;231(1):39-46. Unique Identifier : AIDSLINE MED/95219883
Rodriguez Rodriguez EM; Sanz Alaejos M; Diaz Romero C; Department of Analytical Chemistry, Food Science and Toxicology,; University of La Laguna, Spain.
Urinary selenium (Se) concentrations (micrograms Se/l and microgram Se/g creatinine) have been determined in heroin abusers and in healthy controls. Heroin abusers showed significantly (P


Interaction of HIV-1 gp120 molecule fragments with human monocytes: different requirements for tumor necrosis factor-alpha and IL-6 production.
Clin Immunol Immunopathol. 1995 May;75(2):131-9. Unique Identifier : AIDSLINE MED/95219910
Zembala M; Pryjma J; Plucienniczak A; Szczepanek A; Jasinski M; Ruggiero I; Piselli P; Colizzi V; Department of Clinical Immunology, Polish-American Institute of; Pediatrics, Jagiellonian University Medical College, Cracow.
The HIV-1 gp120 recombinant protein fragment encompassing aa residues 410-511, that contains the CD4 binding region (rp120cd), and fragment aa 446-511, which lacks the sequence responsible for CD4 binding (rp120), were synthesized to study their ability to induce TNF synthesis in human monocytes. The rp120cd stimulate


Quantitative differences in CD8+ lymphocytes, CD4/CD8 ratio, NK cells, and HLA-DR(+)-activated T cells of racially different male populations.
Clin Immunol Immunopathol. 1995 May;75(2):168-70. Unique Identifier : AIDSLINE MED/95219915
Shahabuddin S; Department of Pathology (32), College of Medicine, King Saud; University, Riyadh, Saudi Arabia.
In an attempt to establish the reference ranges for lymphocyte subsets the distribution of lymphocyte-population-bearing surface markers such as CD3 (T cells), CD19 (B cells), CD4 (T helper/inducer cells), CD8 (T suppressor/cytotoxic cells), HLA-DR on CD3+ cells (activated T cells), and CD16 and/or CD56 on CD3- cells


[Prevalence of patients with HIV infection in an emergency department]
Clin Ter. 1995 Jan;146(1):75-8. Unique Identifier : AIDSLINE MED/95219957
Greco GM; Paparo R; Ventura R; Migliardi C; Tallone R; Moccia F; Dipartimento di Emergenza dell'Ospedale S. Martino di Genova.
The activity at an ED, primarily aiming at providing rational and qualified support to critically ill patients, is forced to manage very different nosographic entities, including infectious, often contagious, pathologies. In this context the diffusion of HIV infection poses a number of problems concerning both the kin


Small volume bronchoalveolar lavage used in diagnosing Pneumocystis carinii pneumonia in HIV-infected patients.
Chest. 1995 Apr;107(4):1013-7. Unique Identifier : AIDSLINE MED/95220054
Torrington KG; Finelli MR; Pulmonary and Critical Care Medicine Service, Walter Reed Army; Medical Center, Washington, DC, 20307, USA.
To determine the volume of bronchoalveolar lavage (BAL) fluid necessary to diagnose Pneumocystis carinii pneumonia (PCP) in immunocompromised patients, specimens from 25 patients were evaluated. Twenty-one patients were HIV infected. BAL was performed using three to four 60-mL aliquots of room temperature, sterile, sa


The impact of prophylaxis on outcome and resource utilization in Pneumocystis carinii pneumonia.
Chest. 1995 Apr;107(4):1018-23. Unique Identifier : AIDSLINE MED/95220055
Gallant JE; McAvinue SM; Moore RD; Bartlett JG; Stanton DL; Chaisson RE; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, MD, USA.
STUDY OBJECTIVE: Pneumocystis carinii pneumonia (PCP) is a major late complication of HIV infection associated with morbidity and mortality. Because chemoprophylaxis is highly effective, cases of PCP can be viewed as failures in the management of HIV disease. METHODS: We reviewed demographic, clinical, and cost data f


Clarithromycin in the treatment of Mycobacterium avium lung infections in patients without AIDS. Clarithromycin Study Group of France.
Chest. 1995 Apr;107(4):1035-40. Unique Identifier : AIDSLINE MED/95220059
Dautzenberg B; Piperno D; Diot P; Truffot-Pernot C; Chauvin JP; Pulmonary Department, Groupe Hospitalier Pitie-Salpetriere,; Paris, France.
Mycobacterium avium complex infections, common in patients with AIDS as either pulmonary or disseminated disease, are infrequent in patients without AIDS. Participants were 45 HIV-negative patients with lung disease and positive sputum cultures for M avium; 10 had documented immunocompromise, and 24 had preexisting lu


The effects of long term zidovudine therapy and Pneumocystis carinii prophylaxis on HIV disease. A review of the literature [published erratum appears in Drugs 1995 Apr;49(4):554]
Drugs. 1995 Jan;49(1):20-36. Unique Identifier : AIDSLINE MED/95220168
Hoover DR; School of Hygiene and Public Health, Johns Hopkins University,; Baltimore, Maryland, USA.
Two lines of attack have been used against HIV-1 disease: (1) antiretroviral therapy (notably zidovudine) directed against the HIV-1 virus; and (2) chemoprophylaxis against end-stage diseases of HIV-1 infection, most notably against Pneumocystis carinii pneumonia. Many studies and clinical trials have found that zidov


HIV-1 and the developing human nervous system: in vivo and in vitro aspects.
Dev Neurosci. 1994;16(3-4):137-44. Unique Identifier : AIDSLINE MED/95220175
Tardieu M; Janabi N; Laboratoire de Neurovirologie et Neuroimmunologie, Universite; Paris XI, France.
HIV-1 is able to penetrate the developing human central nervous system and induce damage. Clinical and neuropathological observations demonstrate that (a) the virus is transmitted during the late phase of pregnancy or at the time of delivery; (b) the main infected cells within the brain are macrophages, and (c) the me


Neuronal injury associated with HIV-1 and potential treatment with calcium-channel and NMDA antagonists.
Dev Neurosci. 1994;16(3-4):145-51. Unique Identifier : AIDSLINE MED/95220176
Lipton SA; Department of Neurology, Children's Hospital, Boston, Mass.
A substantial number of adults and half of the children with acquired immunodeficiency syndrome (AIDS) suffer from neurological manifestations. Among the various pathologies reported in brains of patients with AIDS is neuronal injury and loss, although neurons themselves do not appear to be infected by HIV-1. There is


Bone marrow involvement in non-Hodgkin's lymphoma in Zimbabwe.
East Afr Med J. 1994 Dec;71(12):773-5. Unique Identifier : AIDSLINE MED/95220241
Adewuyi B; Coutts A; Levy L; Klein S; Muronda C; Department of Haematology, University of Zimbabwe, Harare.
Lymph node and bone marrow trephine biopsies of seventy two consecutive cases of non-Hodgkin s lymphoma occurring among black Zimbabweans were reviewed to determine bone marrow involvement. The bone marrow was involved in 23.6% of patients but the proportion of bone marrow positive


Resource utilization patterns in patients with acquired immunodeficiency syndrome (AIDS).
East Afr Med J. 1994 Dec;71(12):816-7. Unique Identifier : AIDSLINE MED/95220254
Okello DO; Makerere Medical School, Kampala, Uganda.
A survey in 1991 of resource use patterns and factors affecting the cost of care for the acquired immunodeficiency syndrome (AIDS) in Mulago Hospital, Kampala, Uganda , revealed that drugs constitute 97% of the mean cost of care of affected individuals in the outpatient and 37% in h


The AIDS epidemic: 'it ain't over yet'.
Emphasis Nurs. 1995;5(1):9-17. Unique Identifier : AIDSLINE MED/95220280
Tetreault D; Martin MA; Cox PH; Chang E
NF-kappa B transcription factor and human immunodeficiency virus type 1 (HIV-1) activation by methylene blue photosensitization.
Eur J Biochem. 1995 Mar 1;228(2):447-55. Unique Identifier : AIDSLINE MED/95220375
Piret B; Legrand-Poels S; Sappey C; Piette J; Laboratory of Virology, University of Liege, Belgium.
Reactive oxygen species like hydrogen peroxide (H2O2) have been shown to serve as messengers in the induction of NF-kappa B and then in the activation and replication of HIV-1 in human cells. Because singlet oxygen (1O2) is another very important reactive oxygen species whose action in transcription factor activation


Comparison of lymphokine secretion and mRNA expression in the CD45RA+ and CD45RO+ subsets of human peripheral blood CD4+ and CD8+ lymphocytes.
Eur J Immunol. 1995 Mar;25(3):644-8. Unique Identifier : AIDSLINE MED/95220409
Conlon K; Osborne J; Morimoto C; Ortaldo JR; Young HA; Laboratory of Experimental Immunology, National Cancer Institute,; Frederick, MD 21702-1201, USA.
Flow cytometric analysis of human peripheral blood T lymphocytes demonstrated that the majority of the CD4+ cells were CD29+ or CD45RO+ mature cells while the CD8+ cells were primarily CD45RA+ native cells. After an initial separation into CD4+ and CD8+ cells and a secondary separation into CD45 subsets, lymphokine se


Linked in vivo expression of soluble interleukin-4 receptor and interleukin-4 in murine schistosomiasis.
Eur J Immunol. 1995 Mar;25(3):649-56. Unique Identifier : AIDSLINE MED/95220410
Fernandez-Botran R; Wynn TA; Hieny S; Caspar P; Chilton PM; Sher A; Department of Pathology, School of Medicine, University of; Louisville, KY 40292, USA.
Soluble interleukin-4 receptors (sIL-4R) are truncated IL-4R molecules that are secreted into biological fluids. To gain an insight into the mechanisms that control sIL-4R synthesis in vivo and their role in the regulation of immune responses, the expression and secretion of sIL-4R in mice infected with Schistosoma ma


Regulation of the interaction between Th1 and Th2 T cell clones to provide help for antibody production in vivo.
Eur J Immunol. 1995 Mar;25(3):708-16. Unique Identifier : AIDSLINE MED/95220418
Rizzo LV; DeKruyff RH; Umetsu DT; Caspi RR; National Eye Institute, National Institutes of Health, Bethesda,; MD 20892-1858, USA.
On the premise that an individual with an intact immune system has the capability to develop both cellular and antibody immune responses supported by the balance between the lymphokines secreted by T helper (Th) cells, we studied the interaction between different types of Th cell clones in vivo and the parameters that


HLA-dependent variations in human immunodeficiency virus Nef protein alter peptide/HLA binding.
Eur J Immunol. 1995 Mar;25(3):728-32. Unique Identifier : AIDSLINE MED/95220421
Couillin I; Connan F; Culmann-Penciolelli B; Gomard E; Guillet JG; Choppin J; Unite 152, Institut National de la Sante et de la Recherche; Medicale, Institut Cochin de Genetique, Moleculaire, Paris,; France.
In human immunodeficiency virus (HIV) infection, sequence variations within defined cytotoxic T lymphocyte (CTL) epitopes may lead to escape from CTL recognition. In a previous report, we have shown that the variable central region of HIV Nef protein (amino acids 73-144) that contains potential CTL epitopes, can escap


The triaminopyridine flupirtine prevents cell death in rat cortical cells induced by N-methyl-D-aspartate and gp120 of HIV-1.
Eur J Pharmacol. 1994 Dec 15;288(1):27-33. Unique Identifier : AIDSLINE MED/95220493
Perovic S; Schleger C; Pergande G; Iskric S; Ushijima H; Rytik P; Muller WE; Institut fur Physiologische Chemie, Abteilung Angewandte; Molekularbiologie, Universitat, Mainz, Germany.
Flupirtine, a triaminopyridine derivative, is a non-opiate centrally acting analgesic agent with muscle relaxant properties. Now we show that this drug displays a potent cytoprotective effect on neurons (rat cortical cells) treated with (i) the excitatory amino acid N-methyl-D-aspartate (NMDA) or (ii) with the human i


The effect of CMV infection on progression of human immunodeficiency virus disease is a cohort of haemophilic men followed for up to 13 years from seroconversion.
Epidemiol Infect. 1995 Apr;114(2):361-72. Unique Identifier : AIDSLINE MED/95220525
Sabin CA; Phillips AN; Lee CA; Janossy G; Emery V; Griffiths PD; Department of Public Health, Royal Free Hospital School of; Medicine, London, UK.
The effect of prior infection with cytomegalovirus ( CMV ) on progression of HIV disease in a cohort of 111 men with haemophilia was studied after 13 years follow-up. The relative hazards associated with CMV positivity on progr


Rhodotorula Rubra peritonitis in an HIV+ patient on CAPD.
Del Med J. 1995 Mar;67(3):184. Unique Identifier : AIDSLINE MED/95220549
Pennington JC 3rd; Hauer K; Miller W; Section of Infectious Disease, Medical Center of Delaware, USA.
HIV infection presenting as polymyositis.
Del Med J. 1995 Mar;67(3):185. Unique Identifier : AIDSLINE MED/95220550
Marcum J; University of Kentucky, USA.
Public perceptions about AIDS.
Del Med J. 1995 Mar;67(3):199-202. Unique Identifier : AIDSLINE MED/95220553
The inadequacy of standard treatment of dysplasias in a woman with acquired immune deficiency syndrome.
Int J Gynaecol Obstet. 1994 Dec;47(3):273-4. Unique Identifier : AIDSLINE MED/95220564
Del Priore G; Lee MJ; Barnes M; Garcia P; Till M; Department of Obstetrics and Gynecology, University of Rochester,; NY 14642.
The current state of knowledge regarding the gynecologic care of HIV-infected women is in its infancy. Standard algorithms are not valid. We present an example of the inadequacy of routine surveillance and treatment methods in these patients. Practitioners should maintain a high index of suspicion for multifocal genit


[Prevalence of hepatitis C, B and D markers and histopathological aspects in a group of intravenous drug addicts]
Gastroenterol Clin Biol. 1994;18(11):964-8. Unique Identifier : AIDSLINE MED/95220617
Lucidarme D; Foutrein P; Creusy C; Forzy G; Foutrein-Comes MC; Muyssen A; Bailly D; Parquet PJ; Filoche B; Service de Pathologie Digestive, CH Saint-Philibert, Lomme.
OBJECTIVES--The aim of this study was to assess the prevalence of infection by HCV, HBV, HDV and HIV and their biological and histopathological patterns in 104 intravenous drug users. METHODS AND RESULTS--Seventy-five patients (72%) had anti-HCV antibodies. Transmission was rapid because 33% of those who had been drug


The value of cervical cytology in HIV-infected women.
Gynecol Oncol. 1995 Mar;56(3):395-8. Unique Identifier : AIDSLINE MED/95220715
Del Priore G; Maag T; Bhattacharya M; Garcia PM; Till M; Lurain JR; Department of Obstetrics and Gynecology, Northwestern University,; Evanston, Illinois 60201.
The purpose of this study was to assess the ability of cytology to predict the results of colposcopically directed cervical biopsies in HIV-infected women. We performed a case-control study of 52 HIV(+), 31% of whom had AIDS, and 57 HIV(-) women referred to two tertiary care centers for colposcopy from July 1991 to No


Activated (HLA-DR+) T-lymphocyte subsets in cervical carcinoma and effects of radiotherapy and immunotherapy with sizofiran on cell-mediated immunity and survival.
Gynecol Oncol. 1995 Mar;56(3):412-20. Unique Identifier : AIDSLINE MED/95220719
Miyazaki K; Mizutani H; Katabuchi H; Fukuma K; Fujisaki S; Okamura H; Department of Obstetrics and Gynecology, Kumamoto University; School of Medicine, Japan.
A prospective randomized trial on 312 patients with locally advanced cervical carcinoma (FIGO stages IB-IV) was carried out. The 5-year survival in 90 patients treated with radiotherapy and antitumor polysaccharide sizofiran, an extract from the culture broth of Schizophyllum commune Fries, in combination was signific


Effect of combination chemotherapy with cisplatin and cyclophosphamide on human immunodeficiency virus type-1 surrogate markers in a patient with advanced epithelial ovarian cancer.
Gynecol Oncol. 1995 Apr;57(1):105-8. Unique Identifier : AIDSLINE MED/95220734
Fishman DA; Viscarello RR; Cass I; Schwartz PE; Division of Gynecologic Oncology, Yale University School of; Medicine, New Haven, Connecticut 06520, USA.
This is the first report to evaluate the effects of combination chemotherapy on HIV-1 surrogate markers in an HIV-1-infected patient with an advanced epithelial ovarian cancer. Cisplatin combined with cyclophosphamide was well-tolerated, without significant changes in the HIV-1 p24 antigen, neopterin, beta 2-microglob


Stable antiviral expression (SAVE) as an approach to somatic cell gene therapy directed against HIV infection.
Hokkaido Igaku Zasshi. 1994 Nov;69(6):1288-93. Unique Identifier : AIDSLINE MED/95220799
De Maeyer E; Seif I; Vieillard V; Cases O; Rousseau V; De Maeyer-Guignard J; Lauret E; CNRS-URA 1343, Institut Curie, Centre Universitaire, Orsay,; France.
We are developing methods for somatic cell gene therapy directed against infection with human immunodeficiency virus by enhancing the antiviral resistance of target cells through the constitutive production of interferon-beta. Cells that have been transformed by plasmids or retroviral vectors carrying the human interf


[Rat model of HTLV-I infection--ultrastructural study of HAM rat disease]
Hokkaido Igaku Zasshi. 1994 Nov;69(6):1399-408. Unique Identifier : AIDSLINE MED/95220811
Abe M; Third Department of Internal Medicine, Hokkaido University School; of Medicine, Sapporo, Japan.
HAM (HTLV-I-associated myelopathy) rat disease, HAM/TSP (HTLV-I-associated myelopathy/tropical spastic paraparesis)-like myelopathy in rats, occurred in 8 of 8 HTLV-I (Human T cell leukemia virus type I) carrier rats of WKAH strain inoculated with MT-2 cells at either neonates or 4 to 6 months of age. We report here u


Immunopathological characteristics of in situ T-cell subpopulations in human immunodeficiency virus-associated nephropathy.
Hum Pathol. 1995 Apr;26(4):408-15. Unique Identifier : AIDSLINE MED/95220895
Rey L; Viciana A; Ruiz P; Department of Pathology, University of Miami School of Medicine,; FL 33101, USA.
Human immunodeficiency virus-associated nephropathy (HI-VAN) is a common form of nephropathy present in HIV-infected individuals that clinically presents with proteinuria that is frequently in the nephrotic range, less often with hematuria, and with a course that may evolve to irreversible azotemia ultimately resultin


STD/HIV control in Malawi and the search for affordable and effective urethritis therapy: a first field evaluation [see comments]
Genitourin Med. 1994 Dec;70(6):384-8. Unique Identifier : AIDSLINE MED/95220937
Lule G; Behets FM; Hoffman IF; Dallabetta G; Hamilton HA; Moeng S; Liomba G; Cohen MS; University of Malawi, College of Medicine, Blantyre.
OBJECTIVES--To evaluate gonococcal (GU) and nongonococcal urethritis (NGU), chlamydia antigen, and serostatus for syphilis and human immunodeficiency virus (HIV) among males attending a Malawian STD clinic with complaints of urethral discharge and/or dysuria. To collect demographic and behavioural data and to determin


Kaposi's sarcoma in HIV infected women in Germany: more evidence for sexual transmission. A report of 10 cases and review of the literature [see comments]
Genitourin Med. 1994 Dec;70(6):394-8. Unique Identifier : AIDSLINE MED/95220939
Albrecht H; Helm EB; Plettenberg A; Emminger C; Heise W; Schwartlander B; Stellbrink HJ; Department of Internal Medicine, University Clinic Eppendorf,; Hamburg.
OBJECTIVE--To assess the natural history of Kaposi s sarcoma (KS) in HIV-positive women living in Germany . METHODS--All physicians reporting the diagnosis of KS in a female patient were contacted and asked for detailed information. DESIGN--Descriptive study of clinical, epidemiolo


Barrier methods of contraception, spermicides, and sexually transmitted diseases: a review [see comments]
Genitourin Med. 1994 Dec;70(6):410-7. Unique Identifier : AIDSLINE MED/95220943
d'Oro LC; Parazzini F; Naldi L; La Vecchia C; Istituto di Richerche Farmacologiche Mario Negri, Milan, Italy.
OBJECTIVE--To understand whether barrier methods of contraception (BMC) and/or spermicides lower the risk of acquiring sexually transmitted disease (STD) and to quantify the protection. DESIGN--Review of published experimental studies, in vitro and in vivo evidence on the issue. SUBJECTS--We reviewed 22 papers that ex


STDs and AIDS in Ghana.
Genitourin Med. 1994 Dec;70(6):418-23. Unique Identifier : AIDSLINE MED/95220944
Pellow D; Department of Anthropology, Syracuse University, New York; 13244-1200, USA.
The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines.
Int J Cancer. 1995 Mar 29;61(1):130-7. Unique Identifier : AIDSLINE MED/95221021
Balzarini J; Verstuyf A; Hatse S; Goebels J; Sobis H; Vandeputte M; De Clercq E; Laboratory of Virology and Experimental Chemotherapy, Rega; Institute for Medical Research, Catholic University, Louvain,; Belgium.
9-(2-phosphonylmethoxyethyl)adenine (PMEA) is the prototype compound of a series of acyclic nucleoside phosphonate derivatives endowed with potent and selective anti-retroviral activity in vitro and in vivo. We have now found that PMEA is also a potent inducer of differentiation of a number of tumor cells, including h


Human T-cell lymphotropic virus type I and severe neoplasia of the cervix in Jamaica.
Int J Cancer. 1995 Mar 29;61(1):23-6. Unique Identifier : AIDSLINE MED/95221025
Strickler HD; Rattray C; Escoffery C; Manns A; Schiffman MH; Brown C; Cranston B; Hanchard B; Palefsky JM; Blattner WA; Viral and Environmental Epidemiology Branches, National Cancer; Institute, Bethesda, MD, USA.
Human T-cell lymphotropic virus type I (HTLV-I) was associated with carcinoma of the cervix in Japan in a recent study that compared hospital cases with healthy population-based controls. To test this relationship in women more alike for cervical neoplasia risk factors (including se


Molecular analysis of tumours from feline immunodeficiency virus (FIV)-infected cats: an indirect role for FIV?
Int J Cancer. 1995 Apr 10;61(2):227-32. Unique Identifier : AIDSLINE GENBANK/X03690
Terry A; Callanan JJ; Fulton R; Jarrett O; Neil JC; Department of Veterinary Pathology, University of Glasgow, UK.
Five tumours, which arose in cats naturally or experimentally infected with feline immunodeficiency virus (FIV), were examined with molecular probes to establish tumour cell lineage and to screen for integrated viral sequences. Three of the tumours were classed as B-cell lymphomas on the basis of morphology, immunocyt


Rejection of mouse melanoma elicited by local secretion of interleukin-2: implicating macrophages without T cells or natural killer cells in tumor rejection.
Int J Cancer. 1995 Apr 10;61(2):253-60. Unique Identifier : AIDSLINE MED/95221056
Hara I; Nguyen H; Takechi Y; Gansbacher B; Chapman PB; Houghton AN; Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Tumor cells transduced with cytokine genes provide a model to study host-effector mechanisms involved in tumor rejection. Local IL-2 production within a tumor site mimics a specific helper-T-cell response, bypassing an immunization phase. Growth of mouse B16F10 melanom


Immunologic characterization of TAT72-transgenic mice: effects of morphine on cell-mediated immunity.
Int J Immunopharmacol. 1994 Dec;16(12):1061-70. Unique Identifier : AIDSLINE MED/95221069
Garza HH Jr; Prakash O; Carr DJ; Department of Microbiology, Louisiana State University Medical; Center, New Orleans 70112-1393.
The immunosuppressive effect of morphine in an HIV-1 transactivator of transcription (TAT)-transgenic mouse model was investigated in order to elucidate possible mechanisms of human immunodeficiency virus (HIV)-1 disease progression. The TAT72 transgene (1-72 amino acids) was placed under the control of SV40 viral pro


School nursing. A collaborative approach to HIV/AIDS health promotion.
Health Visit. 1995 Feb;68(2):74-5. Unique Identifier : AIDSLINE MED/95221191
Taylor A; Stott J
The involvement of school nurses in the planning, presentation and delivery of both general health education and sex education in schools in Wirral has been strengthened by the development since 1990 of the school nurses HIV/Aids resource group. Ann Taylor and Joan Stott describe how they have worked closely with Wir


Connecting and disconnecting: bereavement experiences of six mothers whose sons died of AIDS.
Health Care Women Int. 1995 Jan-Feb;16(1):85-95. Unique Identifier : AIDSLINE MED/95221246
Longman AJ
The bereavement experiences of 6 mothers whose sons died of AIDS-related complications were identified. Interviews with these women provided data for grounded-theory analysis. Two basic social processes were identified: Connecting and Disconnecting. Connecting included support, rituals, transitions, and gathering meme


Level of interactivity of videodisc instruction on college students' recall of AIDS information.
J Appl Behav Anal. 1995 Spring;28(1):85-6. Unique Identifier : AIDSLINE MED/95221256
Kritch KM; Bostow DE; Dedrick RF; College of Education, University of South Florida, Tampa 33620.
Experiment 1 confirmed the greater effectiveness of constructed-response interactive videodisc instruction when compared to a click-to-continue or passive viewing formats on posttest recall of AIDS information by 101 college students. Experiment 2 extended the analysis using a counterbalanced (ABAB-BABA) intrasubject


Human microsporidiosis.
J Antimicrob Chemother. 1994 Nov;34(5):609-11. Unique Identifier : AIDSLINE MED/95221259
Ruf B; Sandfort J; Department of Infectious Diseases, Universitatsklinikum Rudolf; Virchow, Berlin, Germany.
High prevalence of antifungal resistance in Candida spp. from patients with AIDS.
J Antimicrob Chemother. 1994 Nov;34(5):659-68. Unique Identifier : AIDSLINE MED/95221264
Law D; Moore CB; Wardle HM; Ganguli LA; Keaney MG; Denning DW; Department of Microbiology, University of Manchester, Hope; Hospital, Salford, UK.
Three hundred and forty-eight isolates of Candida spp. from patients treated at a regional infectious diseases unit for AIDS, immunocompromised patients admitted to the Hope Hospital and isolates referred from around the North West of England were tested for their in-vitro susceptibility to amphotericin B, fluconazole


Preoperative autologous donation: surgery clinic staff knowledge/attitudes. Preoperative Autologous Blood Donation Study Group.
J Clin Apheresis. 1994;9(3):168-70. Unique Identifier : AIDSLINE MED/95221301
Randels MJ; Ferguson K; Strauss RG; Daniels M; Stehling L; Toy P; University of Iowa Hospitals and Clinics, Elmer L. DeGowin; Memorial Blood Center, Department of Pathology, Iowa City 55242.
Preoperative autologous blood donation (PABD) is both under- and overused. Although the decision to order PABD lies with the surgeon, it is quite likely that other surgery clinic personnel influence patient acceptance and enrollment into PABD programs. Accordingly, we measured knowledge, attitudes, and the referral pr


Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor IIB, and coactivators.
J Biol Chem. 1995 Mar 31;270(13):7219-26. Unique Identifier : AIDSLINE MED/95221373
Schmitz ML; Stelzer G; Altmann H; Meisterernst M; Baeuerle PA; Institute of Biochemistry, Albert Ludwigs University, Freiburg,; Federal Republic of Germany.
We show that the transactivating COOH terminus of the p65 subunit of human transcription factor NF-kappa B directly binds the general transcription factors TFIIB and TATA-binding protein (TBP) in vitro. Interaction of p65 with TFIIB required the most COOH-terminal sequence repeat within TFIIB. A functional interaction


The mapping of HIV-1 gp160 epitopes required for interleukin-1 and tumor necrosis factor alpha production in glial cells.
J Neuroimmunol. 1995 Mar;57(1-2):179-91. Unique Identifier : AIDSLINE MED/95221573
Koka P; He K; Camerini D; Tran T; Yashar SS; Merrill JE; Department of Neurology, Reed Neurological Research Center,; School of Medicine, University of California, Los Angeles 90024,; USA.
The pathology in central nervous system (CNS) AIDS suggests that direct infection with HIV-1 is not required for changes in glia and neurons. Induction of a variety of pathological responses in vitro in rodent brain cultures also suggests that CD4 is not the receptor for HIV-1 in the brain, given that human and rodent


Phenotypic and functional changes in peripheral blood monocytes during progression of human immunodeficiency virus infection. Effects of soluble immune complexes, cytokines, subcellular particulates from apoptotic cells, and HIV-1-encoded proteins on monocytes phagocytic function, oxidative burst, transendothelial migration, and cell surface phenotype.
J Clin Invest. 1995 Apr;95(4):1690-701. Unique Identifier : AIDSLINE MED/95221621
Trial J; Birdsall HH; Hallum JA; Crane ML; Rodriguez-Barradas MC; de Jong AL; Krishnan B; Lacke CE; Figdor CG; Rossen RD; Research Center for AIDS and HIV-related Infections, Veterans; Affairs Medical Center, Houston, Texas 77030, USA.
We postulated that changes in the cell surface display of molecules that facilitate cell-cell and cell-matrix adhesions may reflect the changing immunosurveillance capacity of blood monocytes during progression of human immunodeficiency virus (HIV) infections. In Centers for Disease Control (CDC) stage A patients, who


Immune predispositions for cytomegalovirus retinitis in AIDS. The HNRC Group.
J Clin Invest. 1995 Apr;95(4):1741-6. Unique Identifier : AIDSLINE MED/95221627
Schrier RD; Freeman WR; Wiley CA; McCutchan JA; Department of Pathology, University of California, San Diego, La; Jolla 92093, USA.
CMV retinitis develops in approximately 28-35% of all AIDS patients at later stages of disease, often leading to blindness. To determine whether the subset of AIDS patients who developed CMV retinitis (CMV-R) were immunologically predisposed, T cell proliferatio


Specificity and usefulness of an IgE immunosorbent agglutination assay for toxoplasmosis.
J Clin Pathol. 1995 Jan;48(1):64-9. Unique Identifier : AIDSLINE MED/95221676
Ashburn D; Joss AW; Pennington TH; Ho-Yen DO; Microbiology Department, Raigmore Hospital, Inverness.
AIMS--To develop an immunosorbent agglutination assay for the detection of Toxoplasma gondii IgE antibodies (IgE-ISAGA); to assess its specificity; and to determine the role of specific IgE in the diagnosis of current toxoplasma infection. METHODS--Rabbit antihuman IgE capture antibody was adsorbed onto microtitre pla


Routine diagnosis of Pneumocystis carinii pneumonia [letter; comment]
J Clin Pathol. 1995 Jan;48(1):91-2. Unique Identifier : AIDSLINE MED/95221685
Evans R; Joss A; Ho-Yen D; Whyte KF
Intracellular signaling events during positive and negative selection of CD4+CD8+ thymocytes in vitro.
J Immunol. 1995 Apr 15;154(8):3636-43. Unique Identifier : AIDSLINE MED/95221867
Anderson G; Anderson KL; Conroy LA; Hallam TJ; Moore NC; Owen JJ; Jenkinson EJ; Department of Anatomy, Medical School, University of Birmingham,; Edgbaston, United Kingdom.
We have used in vitro models of thymocyte positive and negative selection in conjunction with selective inhibitors of the TCR-mediated signaling cascade to investigate the intracellular signaling events that mediate these processes. We report that Ro 31.8425, a potent and selective inhibitor of protein kinase C, which


IL-8-induced signal transduction in T lymphocytes involves receptor-mediated activation of phospholipases C and D.
J Immunol. 1995 Apr 15;154(8):3654-66. Unique Identifier : AIDSLINE MED/95221869
Bacon KB; Flores-Romo L; Life PF; Taub DD; Premack BA; Arkinstall SJ; Wells TN; Schall TJ; Power CA; Glaxo Institute for Molecular Biology, Geneva, Switzerland.
We have characterized the IL-8-induced signal transduction processes in T lymphocytes. A basal level of IL-8 receptor expression was shown on mixed PBL, as identified by using phycoerythrin (PE)-coupled IL-8, and this expression was increased following IL-2 stimulation


CD27-CD27 ligand/CD70 interactions enhance alloantigen-induced proliferation and cytolytic activity in CD8+ T lymphocytes.
J Immunol. 1995 Apr 15;154(8):3686-95. Unique Identifier : AIDSLINE MED/95221872
Brown GR; Meek K; Nishioka Y; Thiele DL; Department of Internal Medicine, University of Texas Southwestern; Medical Center at Dallas 75235, USA.
To study the role of CD27-CD27 ligand (CD27L)/CD70 interactions in the generation of murine allospecific T cell responses, SF9 cells or cell membranes expressing recombinant human CD70 were added to in vitro MLC containing C57BL/6 (H-2b) responder cells and class I and II MHC disparate H-2b/d stimulator cells. Alloant


Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4.
J Immunol. 1995 Apr 15;154(8):3779-87. Unique Identifier : AIDSLINE MED/95221882
Mocci S; Coffman RL; DNAX Research Institute of Molecular and Cellular Biology; Incorporated, Palo Alto, CA 94304, USA.
The infection of mice with Leishmania major parasite induces polarized Th1 and Th2 responses that cannot be significantly changed in vivo after 2 to 3 wk of infection by using either cytokines or anti-cytokine Abs. It is not clear, however, whether the T cell populations are irreversibly differentiated or whether the


Expression of the Fas ligand in cells of T cell lineage.
J Immunol. 1995 Apr 15;154(8):3806-13. Unique Identifier : AIDSLINE MED/95221885
Suda T; Okazaki T; Naito Y; Yokota T; Arai N; Ozaki S; Nakao K; Nagata S; Department of Molecular Biology, Osaka Bioscience Institute,; Japan.
Fas ligand (FasL) is a membrane-type cytokine belonging to the TNF family, and induces apoptosis through its cell-surface receptor, Fas. To determine the cell types that express FasL, various mouse tissues and cell lines were examined by Northern hybridization using a mouse FasL cDNA as a probe. Among tissues, lymphoi


Do HLA genes play a prominent role in determining T cell receptor V alpha segment usage in humans?
J Immunol. 1995 Apr 15;154(8):3843-51. Unique Identifier : AIDSLINE MED/95221889
Gulwani-Akolkar B; Shi B; Akolkar PN; Ito K; Bias WB; Silver J; Departments of Medicine, North Shore University Hospital, Cornell; University Medical College, Manhasset, NY 11030, USA.
Previous studies in humans have demonstrated that HLA genes can profoundly influence the TCR V beta repertoire. To similarly assess the influence of HLA genes on the TCR V alpha segment repertoire, the V alpha repertoires of 12 individuals from three unrelated families were determined by quantitative PCR. Each family


Importance of TNF production for the curative effectiveness of low dose melphalan therapy for mice bearing a large MOPC-315 tumor.
J Immunol. 1995 Apr 15;154(8):3941-51. Unique Identifier : AIDSLINE MED/95221899
Gorelik L; Rubin M; Prokhorova A; Mokyr MB; Department of Microbiology and Immunology, University of Illinois; at Chicago, 60680, USA.
We have previously shown the importance of the acquisition of CD8+ T cell-dependent tumor-eradicating immunity for the curative effectiveness of low dose melphalan (L-PAM, L-phenylalanine mustard) for mice bearing a large MOPC-315 tumor. Here we show the importance of TNF production for the curative effectiveness of l


IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma.
J Immunol. 1995 Apr 15;154(8):3999-4009. Unique Identifier : AIDSLINE MED/95221906
Wynn TA; Jankovic D; Hieny S; Zioncheck K; Jardieu P; Cheever AW; Sher A; Host-Parasite Relations Section, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; MD 20892, USA.
To assess the role of IFN-gamma in the in vivo regulation of Th subset differentiation by IL-12, schistosome egg-induced Th2 responses and granuloma formation were studied in IFN-gamma knock-out (gamma KO) mice in which the absence of endogenous IFN-gamma is assured. Rather than suppressing pathology and eosinophilia


Seminal shedding of human immunodeficiency virus type 1 and human cytomegalovirus: evidence for different immunologic controls.
J Infect Dis. 1995 Apr;171(4):1018-22. Unique Identifier : AIDSLINE MED/95221955
Krieger JN; Coombs RW; Collier AC; Ross SO; Speck C; Corey L; Department of Urology, University of Washington School of; Medicine, Seattle 98195.
Contact with semen of seropositive men is important for sexual transmission both human immunodeficiency virus (HIV) type 1 and human cytomegalovirus ( CMV ), but the factors that determine shedding of either virus in semen are


Evidence for sexual and mother-to-child transmission of human T lymphotropic virus type II among Guaymi Indians, Panama.
J Infect Dis. 1995 Apr;171(4):1022-6. Unique Identifier : AIDSLINE MED/95221956
Vitek CR; Gracia FI; Giusti R; Fukuda K; Green DB; Castillo LC; Armien B; Khabbaz RF; Levine PH; Kaplan JE; et al; Retrovirus Diseases Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333.
Guaymi Indians, a non-intravenous drug-using population in which human T cell lymphotropic virus type II (HTLV-II) is endemic, were studied in Changuinola, Panama , to identify the prevalence and modes of transmission of HTLV-II. A p


Paromomycin treatment against cryptosporidiosis in patients with AIDS [letter]
J Infect Dis. 1995 Apr;171(4):1069-70; discussion 1071. Unique Identifier : AIDSLINE MED/95221970
Tzipori S; Griffiths J; Theodus C
Paromomycin for cryptosporidiosis in AIDS [letter; comment]
J Infect Dis. 1995 Apr;171(4):1070; discussion 1071. Unique Identifier : AIDSLINE MED/95221971
Verdon R; Polianski J; Gaudebout C; Pocidalo JJ
Clarification of a method to reverse transcribe human immunodeficiency virus RNA [letter]
J Infect Dis. 1995 Apr;171(4):1072. Unique Identifier : AIDSLINE MED/95221972
Kozal MJ; Shafer RW; Winters MA; Katzenstein DA; Merigan TC
(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (cidofovir): results of a phase I/II study of a novel antiviral nucleotide analogue.
J Infect Dis. 1995 Apr;171(4):788-96. Unique Identifier : AIDSLINE MED/95221982
Lalezari JP; Drew WL; Glutzer E; James C; Miner D; Flaherty J; Fisher PE; Cundy K; Hannigan J; Martin JC; et al; Department of Medicine, Mount Zion Medical Center, University of; California, San Francisco 94115.
Cidofovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, is a novel antiviral nucleotide analogue with potent in vitro and in vivo activity against cytomegalovirus ( CMV ) and other herpesviruses. Thirty-one human immu


Human immunodeficiency virus type 1 env and p17gag sequence variation in polymerase chain reaction-positive, seronegative injection drug users.
J Infect Dis. 1995 Apr;171(4):797-804. Unique Identifier : AIDSLINE MED/95221983
Markham RB; Yu X; Farzadegan H; Ray SC; Vlahov D; Department of Molecular Microbiology and Immunology, Johns; Hopkins School of Hygiene and Public Health, Baltimore, Maryland; 21205.
Variation in gene sequences from human immunodeficiency virus type 1 (HIV-1) p17gag and the third hypervariable region (V3 loop) of env was examined in a cross-sectional study of single specimens from 4 HIV-1 polymerase chain reaction-positive, seronegative injection drug users. As observed in sexually transmitted dis


Dual infection with human immunodeficiency virus type 1 of distinct envelope subtypes in humans.
J Infect Dis. 1995 Apr;171(4):805-10. Unique Identifier : AIDSLINE GENBANK/U21476
Artenstein AW; VanCott TC; Mascola JR; Carr JK; Hegerich PA; Gaywee J; Sanders-Buell E; Robb ML; Dayhoff DE; Thitivichianlert S; et al; Division of Retrovirology, Walter Reed Army Institute of; Research, Rockville, Maryland 20850.
Multiple genetic subtypes of human immunodeficiency virus type 1 (HIV-1) have been identified among internationally collected isolates. The HIV-1 epidemic in Thailand is largely due to B and E subtypes of virus. Dual infection with distinct HIV-1 subtypes would suggest that antiv


Predictors for non- and slow progression in human immunodeficiency virus (HIV) type 1 infection: low viral RNA copy numbers in serum and maintenance of high HIV-1 p24-specific but not V3-specific antibody levels.
J Infect Dis. 1995 Apr;171(4):811-21. Unique Identifier : AIDSLINE MED/95221985
Hogervorst E; Jurriaans S; de Wolf F; van Wijk A; Wiersma A; Valk M; Roos M; van Gemen B; Coutinho R; Miedema F; et al; Human Retrovirus Laboratory, University of Amsterdam,; Netherlands.
To gain insight into determinants that define the duration of the asymptomatic period preceding AIDS, groups of long-term asymptomatic (LTA) person (> 7 years of follow-up) and slow and rapid progressors of human immunodeficiency virus infection were studied. LTAs had no clinical manifestations of AIDS or immunologic


Identification of human immunodeficiency virus primary isolates resistant to interferon-alpha and correlation of prevalence to disease progression.
J Infect Dis. 1995 Apr;171(4):822-8. Unique Identifier : AIDSLINE MED/95221986
Kunzi MS; Farzadegan H; Margolick JB; Vlahov D; Pitha PM; Oncology Center, Johns Hopkins University, Baltimore, Maryland.
Human immunodeficiency virus (HIV) primary isolates, derived from donors at various stages of HIV infection, were assayed for their sensitivity to interferon (IFN)-alpha 2 in vitro. These isolates displayed a broad range of sensitivity to IFN-alpha 2. The prevalence of IFN-alpha 2 resistance was low in the absence of


Prognostic factors in human immunodeficiency virus-positive patients with a CD4+ lymphocyte count < 50/microL.
J Infect Dis. 1995 Apr;171(4):829-36. Unique Identifier : AIDSLINE MED/95221987
Apolonio EG; Hoover DR; He Y; Saah AJ; Lyter DW; Detels R; Kaslow RA; Phair JP; Northwestern University Medical School, Chicago, Illinois 60611.
This analysis investigated variability of survival time in a cohort of 553 human immunodeficiency virus type 1 (HIV-1)-infected homosexual or bisexual men with or = 2 years. Multivariate analysis showed l


Clinical manifestations and risk factors of Pseudomonas aeruginosa infection in patients with AIDS [published erratum appears in J Infect Dis 1995 Jul;172(1):327]
J Infect Dis. 1995 Apr;171(4):930-7. Unique Identifier : AIDSLINE MED/95222002
Dropulic LK; Leslie JM; Eldred LJ; Zenilman J; Sears CL; Department of Medicine, Johns Hopkins University School of; Medicine, Baltimore, Maryland 21205-2196.
Fifty-eight patients with human immunodeficiency virus infection were analyzed for clinical manifestations and potential risk factors for Pseudomonas aeruginosa infection by use of case-control methodology. Most had AIDS. Of 73 episodes of P. aeruginosa infection, 45 (62%) were bacteremias primarily associated with ce


Coccidioidomycosis among persons with AIDS in the United States.
J Infect Dis. 1995 Apr;171(4):961-6. Unique Identifier : AIDSLINE MED/95222006
Jones JL; Fleming PL; Ciesielski CA; Hu DJ; Kaplan JE; Ward JW; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333.
Adults and adolescents diagnosed with AIDS from 1987 through 1992 residing in counties endemic (selected counties in California, Arizona, Texas, New Mexico, Nevada, Utah) and not endemic for Coccidioides immitis were assessed to determine the frequency of and risk factors for disseminated


Synthetic protease inhibitors: promising compounds to arrest pathobiologic processes.
J Lab Clin Med. 1995 Apr;125(4):433-41. Unique Identifier : AIDSLINE MED/95222088
Roose JP; Van Noorden CJ; Laboratory of Cell Biology and Histology, Academic Medical; Center, University of Amsterdam, The Netherlands.
Pneumocystis carinii alters surfactant protein A concentrations in bronchoalveolar lavage fluid.
J Lab Clin Med. 1995 Apr;125(4):462-9. Unique Identifier : AIDSLINE MED/95222092
Sternberg RI; Whitsett JA; Hull WM; Baughman RP; Department of Internal Medicine, Children's Hospital, University; of Cincinnati, OH, USA.
To understand better the interaction between surfactant protein A (SP-A), human immunodeficiency virus (HIV) and Pneumocystis carinii pneumonia (PCP), we measured SP-A from bronchoalveolar lavage (BAL) fluid in immunosuppressed patients (HIV-positive [HIV+] and HIV noninfected [HIV-]) who were examined for possible pn


Opiates or cocaine: mortality from acute reactions in six major Spanish cities. State Information System on Drug Abuse (SEIT) Working Group.
J Epidemiol Community Health. 1995 Feb;49(1):54-60. Unique Identifier : AIDSLINE MED/95222201
Sanchez J; Rodriguez B; de la Fuente L; Barrio G; Vicente J; Roca J; Royuela L; Delegacion del Gobierno para el Plan Nacional sobre Drogas,; Madrid, Spain.
STUDY OBJECTIVE--To describe temporal and geographical variations in mortality from acute reactions to opiates or cocaine and the demographic and toxicological characteristics of persons who died from these in major Spanish cities between 1983 and 1991. DESIGN--Descriptive study. Data were obtained retrospectively fro


AIDS potpourri.
J Fla Med Assoc. 1995 Feb;82(2):151-4. Unique Identifier : AIDSLINE MED/95222232
Harty-Golder B
Focal brain lesions in patients with AIDS: aetiologies and corresponding radiological patterns in a prospective study.
J Neurol. 1995 Jan;242(2):69-74. Unique Identifier : AIDSLINE MED/95222291
Steinmetz H; Arendt G; Hefter H; Neuen-Jacob E; Dorries K; Aulich A; Kahn T; Department of Neurology, Heinrich-Heine-University, Dusseldorf,; Germany.
We report the results of a hospital-based study of 188 consecutive patients seropositive for the human immune deficiency virus type 1 (HIV-1) who presented in a 4-year period (1988-1991) with possible signs or symptoms of first-ever central nervous system disease. Confirmed diagnoses were cerebral toxoplasmosis in 47


Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: a report of 48 cases.
J Clin Oncol. 1995 Apr;13(4):812-20. Unique Identifier : AIDSLINE MED/95222306
Preudhomme C; Dervite I; Wattel E; Vanrumbeke M; Flactif M; Lai JL; Hecquet B; Coppin MC; Nelken B; Gosselin B; et al; Inserm U124, Laboratoire d'Hematologie A, Centre Oscar Lambret,; Lille, France.
PURPOSE: To correlate the presence of p53 mutations and initial characteristics, response to chemotherapy, and survival in newly diagnosed Burkitt s lymphoma (BL) and Burkitt s acute lymphoblastic leukemia (L3 ALL). PATIENTS AND METHODS: Forty-eight patients with newly diagnosed BL or L3 ALL, most of whom were treated


Liposomal-entrapped doxorubicin: an active agent in AIDS-related Kaposi's sarcoma.
J Clin Oncol. 1995 Apr;13(4):914-20. Unique Identifier : AIDSLINE MED/95222319
Harrison M; Tomlinson D; Stewart S; Department of Oncology, St Mary's Hospital, London, United; Kingdom.
PURPOSE: A phase II study was performed of single-agent liposomally entrapped doxorubicin ([LED] Doxil; Liposome Technology Inc, Menlo Park, CA) against locally advanced cutaneous/systemic AIDS-related Kaposi s sarcoma (KS). PATIENTS AND METHODS: Thirty-four patients with AIDS-relate


Phase I/II clinical and pharmacokinetic evaluation of liposomal daunorubicin.
J Clin Oncol. 1995 Apr;13(4):996-1003. Unique Identifier : AIDSLINE MED/95222331
Gill PS; Espina BM; Muggia F; Cabriales S; Tulpule A; Esplin JA; Liebman HA; Forssen E; Ross ME; Levine AM; Department of Medicine, Kenneth Norris Cancer Hospital and; Research Institute, University of Southern California School of; Medicine, Los Angeles 90033, USA.
PURPOSE: Since liposomal encapsulation of anticancer drugs may enhance antitumor activity while reducing toxicity in vitro, we evaluated liposomally encapsulated daunorubucin (DaunoXome; Vestar, Inc, San Dimas, CA) for safety, pharmacokinetics, and potential efficacy in patients with AIDS-related Kaposi s sarcoma (AID


Patients, needles, and health care workers.
J Intraven Nurs. 1995 Mar-Apr;18(2):65-76. Unique Identifier : AIDSLINE MED/95222376
Hibberd PL
The risk of transmission of blood-borne pathogens in the health care environment is determined by three main factors: the nature and frequency of exposure to blood or body fluids, the risk of transmission of infection after a single exposure to the pathogen, and the prevalence of infected and susceptible patients and


Cross-validated R2-guided region selection for comparative molecular field analysis: a simple method to achieve consistent results.
J Med Chem. 1995 Mar 31;38(7):1060-6. Unique Identifier : AIDSLINE MED/95222517
Cho SJ; Tropsha A; Laboratory for Molecular Modeling, School of Pharmacy, University; of North Carolina, Chapel Hill 27599, USA.
Comparative Molecular Field Analysis (CoMFA) is one of the most powerful modern tools for quantitative structure-activity relationship studies. The CoMFA predictability is conventionally characterized by a cross-validated correlation coefficient R2 (q2). Our CoMFA investigation of 4 datasets, including 7 cephalotaxine


Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 2. 6-Halo and 6-alkoxy prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine.
J Med Chem. 1995 Mar 31;38(7):1189-95. Unique Identifier : AIDSLINE MED/95222529
Ford H Jr; Siddiqui MA; Driscoll JS; Marquez VE; Kelley JA; Mitsuya H; Shirasaka T; Laboratory of Medicinal Chemistry, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.
A series of 6-halo-(F-, Cl-, Br-, I-) and 6-alkoxy-(OMe-, OEt-) 9-(2,3-dideoxy-2-fluoro-beta-D-threopentofuranosyl) purines (F-ddN) have been synthesized and characterized with the objective of finding compounds which might be superior to existing drugs for the treatment of HIV in the central nervous system. These com


Feline immunodeficiency virus infection--a model for HIV and AIDS?
J Med Microbiol. 1995 Apr;42(4):233-6. Unique Identifier : AIDSLINE MED/95222537
Bennett M; Hart CA; Department of Veterinary Clinical Science and Animal Husbandry,; University of Liverpool.
A comparative study of the properties of Vibrio cholerae O139, O1 and other non-O1 strains.
J Med Microbiol. 1995 Apr;42(4):251-7. Unique Identifier : AIDSLINE MED/95222540
Nandy RK; Sengupta TK; Mukhopadhyay S; Ghose AC; Department of Microbiology, Bose Institute, Calcutta, India.
Vibrio cholerae O139 organisms isolated from different parts of India and from Bangladesh were characterised with respect to their haemagglutination (HA) activity, plasmid content, cholera toxin (CT) production, cell surface protein and lipop


Immunological abnormalities in HIV-free haemophiliacs.
J Clin Lab Immunol. 1993;40(4):173-80. Unique Identifier : AIDSLINE MED/95222551
Fukushima Y; Makino M; Fukutake K; Okuyama K; Ueda M; Yorifugi H; Mimaya J; Fujimaki M; Komuro K; Department of Bacterial and Blood Products, National Institute of; Health of Japan, Tokyo.
Since some haemophiliacs manifest profound immunodeficiency with no evidence of human immunodeficiency virus type 1 (HIV) infection, we measured the circulating immune complex (CIC) level in sera obtained from haemophiliacs and addressed the question of whether viral infection is associated directly or indirectly with


Maternal lymphocyte subsets in the cases with neural tube defects.
J Clin Lab Immunol. 1993;40(4):181-6. Unique Identifier : AIDSLINE MED/95222552
Seniz FN; Gurakan BA; Firat S; Kayaalp A; Tokali E; Laleli Y; Karaagaoglu E; Department of Pediatrics Social Security Hospital, Turkey.
Neural tube defects (NTDs) are among the most prevalent of congenital malformations. Organ system anomalies and certain changes in the thymus gland have also been reported. Lymphocyte subset changes can be expected in infants with NTD as a result of these thymic anomalies. We investigated lymphocyte subpopulations in


Initiation of reverse transcription of HIV-1: secondary structure of the HIV-1 RNA/tRNA(3Lys) (template/primer).
J Mol Biol. 1995 Mar 24;247(2):236-50. Unique Identifier : AIDSLINE MED/95222587
Isel C; Ehresmann C; Keith G; Ehresmann B; Marquet R; Unite Propre de Recherche 9002 du Centre National de la; Recherche Scientifique, Strasbourg, France.
Reverse transcription of human immunodeficiency virus type-1 (HIV-1) genomic RNA is primed by tRNA(3Lys), whose 3 end 18 nucleotides are complementary to the viral primer binding site (PBS). We used chemical and enzymatic probes to test the conformation of the viral RNA and tRNA(3Lys), in their free form and in the H


Viaticals for cancer patients gain popularity in U.S. [news]
J Natl Cancer Inst. 1995 Feb 15;87(4):244-5. Unique Identifier : AIDSLINE MED/95222632
Nagy K
Cross-protective immune responses induced in rhesus macaques by immunization with attenuated macrophage-tropic simian immunodeficiency virus.
J Virol. 1995 May;69(5):2737-44. Unique Identifier : AIDSLINE MED/95222718
Clements JE; Montelaro RC; Zink MC; Amedee AM; Miller S; Trichel AM; Jagerski B; Hauer D; Martin LN; Bohm RP; et al; Division of Comparative Medicine, Johns Hopkins University School; of Medicine, Baltimore, MD 21205, USA.
The simian immunodeficiency virus (SIV) macaque model of AIDS has provided a valuable system with which to investigate vaccine approaches for protection against human immunodeficiency virus type 1 (HIV-1) infection. In particular, the ability of macaques persistently infected with attenuated infectious molecular clone


Oligomerization of the hydrophobic heptad repeat of gp41.
J Virol. 1995 May;69(5):2745-50. Unique Identifier : AIDSLINE MED/95222719
Bernstein HB; Tucker SP; Kar SR; McPherson SA; McPherson DT; Dubay JW; Lebowitz J; Compans RW; Hunter E; Department of Microbiology, University of Alabama at Birmingham; 35294-2170, USA.
The transmembrane protein of human immunodeficiency virus type 1 (HIV-1) contains a leucine zipper-like (hydrophobic heptad) repeat which has been predicted to form an amphipathic alpha helix. To evaluate the potential of the hydrophobic heptad repeat to induce protein oligomerization, this region of gp41 has been clo


The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles.
J Virol. 1995 May;69(5):2759-64. Unique Identifier : AIDSLINE MED/95222721
Kondo E; Mammano F; Cohen EA; Gottlinger HG; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Harvard Medical School, Boston, Massachusetts 02115, USA.
The vpr gene of human immunodeficiency virus type 1 (HIV-1) encodes a virion-associated regulatory protein. Mutagenesis has shown that the virion association of Vpr requires sequences near the C terminus of the HIV-1 Gag polyprotein Pr55gag. To investigate whether Vpr incorporation is mediated by a specific domain of


Molecular and functional interactions of transcription factor USF with the long terminal repeat of human immunodeficiency virus type 1.
J Virol. 1995 May;69(5):2765-75. Unique Identifier : AIDSLINE MED/95222722
di Fagagna FD; Marzio G; Gutierrez MI; Kang LY; Falaschi A; Giacca M; International Centre for Genetic Engineering and Biotechnology,; Trieste, Italy.
The human transcription factor USF, purified from HeLa cells, and its recombinant 43-kDa component bind to the long terminal repeat (LTR) of human immunodeficiency virus type 1. The proteins footprint over nucleotides from position -173 to -157 upstream of the transcription start site, generating strong DNAse I hypers


Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization.
J Virol. 1995 May;69(5):2794-800. Unique Identifier : AIDSLINE MED/95222725
Courtois G; Benit L; Mikaeloff Y; Pauchard M; Charon M; Varlet P; Gisselbrecht S; Institut Cochin de Genetique Moleculaire, Institut National de; la Sante et de la Recherche Medicale, Universite Paris V,; Hopital Cochin, France.
The myeloproliferative leukemia retrovirus (MPLV) has the v-mpl cellular sequences transduced in frame with the deleted and rearranged Friend murine leukemia virus env gene. The resulting env-mpl fusion oncogene is responsible for an acute myeloproliferative disorder induced in mice by MPLV. v-mpl is a truncated form


Adaptation of human immunodeficiency virus type 1 to cells expressing a binding-deficient CD4 mutant (lysine 46 to aspartic acid).
J Virol. 1995 May;69(5):2801-10. Unique Identifier : AIDSLINE MED/95222726
Choe HR; Sodroski J; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, MA 02115, USA.
Human immunodeficiency virus (HIV-1) was adapted to replicate efficiently in cells expressing an altered form of the CD4 viral receptor. The mutant CD4 (46 K/D) contained a single amino acid change (lysine 46 to aspartic acid) in the CDR2 loop of domain 1, which results in a 15-fold reduction in affinity for the viral


Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy.
J Virol. 1995 May;69(5):2863-8. Unique Identifier : AIDSLINE MED/95222734
Wattel E; Vartanian JP; Pannetier C; Wain-Hobson S; Unite de Retrovirologie Moleculaire, Institut Pasteur, Paris,; France.
Human T-cell leukemia virus type I (HTLV-I) is associated with adult T-cell leukemia/lymphoma and tropical spastic paraparesis/HTLV-associated myelopathy. Both diseases are usually preceded by a long clinically asymptomatic period. PCR amplification of the HTLV-I proviral integration sites shows that clonal expansion


Repression in vitro, by human adenovirus E1A protein domains, of basal or Tat-activated transcription of the human immunodeficiency virus type 1 long terminal repeat.
J Virol. 1995 May;69(5):2907-11. Unique Identifier : AIDSLINE MED/95222740
Song CZ; Loewenstein PM; Green M; Institute for Molecular Virology, Saint Louis University School; of Medicine, Missouri 63110, USA.
Human adenovirus E1A proteins can repress the expression of several viral and cellular genes. By using a cell-free transcription system, we demonstrated that the gene product of the E1A 12S mRNA, the 243-residue protein E1A243R, inhibits basal transcription from the human immunodeficiency virus type 1 (HIV-1) long ter


The Rev protein of human immunodeficiency virus type 1 counteracts the effect of an AU-rich negative element in the human papillomavirus type 1 late 3' untranslated region.
J Virol. 1995 May;69(5):2932-45. Unique Identifier : AIDSLINE MED/95222744
Tan W; Schwartz S; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.
We have identified a sequence in the late 3 untranslated region of human papillomavirus type 1 mRNAs that acts posttranscriptionally to repress gene expression. Deletion analysis localized the inhibitory element to an AU-rich sequence between nucleotides 6958 and 6984 on the human papillomavirus type 1 genome. This s


Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro.
J Virol. 1995 May;69(5):2977-88. Unique Identifier : AIDSLINE MED/95222749
Spina CA; Guatelli JC; Richman DD; Department of Pathology, University of California at San Diego,; La Jolla 92093-0679, USA.
Human immunodeficiency virus type 1 (HIV-1) possesses the ability to establish a complete infection in nondividing host cells. The capacity of HIV-1 to infect nondividing cells probably contributes significantly to its pathology in vivo, as reflected by infection of peripheral T lymphocytes, tissue macrophages, and mi


Molecular cloning and characterization of a cellular protein that interacts with the human immunodeficiency virus type 1 Tat transactivator and encodes a strong transcriptional activation domain.
J Virol. 1995 May;69(5):3007-16. Unique Identifier : AIDSLINE MED/95222752
Yu L; Zhang Z; Loewenstein PM; Desai K; Tang Q; Mao D; Symington JS; Green M; Institute for Molecular Virology, Saint Louis University School; of Medicine, Missouri 63110, USA.
The mechanism by which human immunodeficiency virus type 1 Tat transactivates the long terminal repeat promoter is not understood. It is generally believed that Tat has one or more transcription factors as its cellular target. One might expect a cellular target for Tat to possess several properties, including (i) the


In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP.
J Virol. 1995 May;69(5):3017-23. Unique Identifier : AIDSLINE MED/95222753
Yu L; Loewenstein PM; Zhang Z; Green M; Institute for Molecular Virology, Saint Louis University School; of Medicine, Missouri 63110, USA.
We have reported the molecular cloning, expression, and characterization of a human cellular protein, TAP, which possesses a strong transcriptional activation domain and binds the human immunodeficiency virus type 1 Tat transactivator in vitro and in vivo (L. Yu, Z. Zhang, P.M. Loewenstein, K. Desai, Q. Tang, D. Mao,


Reduced replication of human immunodeficiency virus type 1 mutants that use reverse transcription primers other than the natural tRNA(3Lys).
J Virol. 1995 May;69(5):3090-7. Unique Identifier : AIDSLINE MED/95222762
Das AT; Klaver B; Berkhout B; Department of Virology, Academic Medical Center, University of; Amsterdam, The Netherlands.
Replication of the human immunodeficiency virus type 1 (HIV-1) and other retroviruses involves reverse transcription of the viral RNA genome into a double-stranded DNA. This reaction is primed by the cellular tRNA(3Lys) molecule, which binds to a complementary sequence in the viral genome, referred to as the primer-bi


Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors.
J Virol. 1995 May;69(5):3098-107. Unique Identifier : AIDSLINE MED/95222763
Sune C; Garcia-Blanco MA; Department of Molecular Cancer Biology, Duke University Medical; Center, Durham, North Carolina 27710, USA.
Expression of human immunodeficiency virus type 1 (HIV-1) genes is regulated by the trans activator Tat. Tat exerts its effects by increasing the rate of transcription, but the mechanism by which it does so is still unknown. To study the cellular factors required for Tat trans activation, we have expressed functional


Macaques immunized with HLA-DR are protected from challenge with simian immunodeficiency virus.
J Virol. 1995 May;69(5):3117-24. Unique Identifier : AIDSLINE MED/95222765
Arthur LO; Bess JW Jr; Urban RG; Strominger JL; Morton WR; Mann DL; Henderson LE; Benveniste RE; AIDS Vaccine Program, PRI/DynCorp, National Cancer; Institute-Frederick Cancer Research and Development Center,; Maryland 21702-1201, USA.
Macaques immunized with uninfected human cells have been shown to be protected from challenge with simian immunodeficiency virus (SIV) propagated in human cells. To identify the potential antigens involved in this protection, macaques were immunized with uninfected human cells, sucrose density gradient-purified cultur


Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding.
J Virol. 1995 May;69(5):3125-33. Unique Identifier : AIDSLINE MED/95222766
Katahira J; Ishizaki T; Sakai H; Adachi A; Yamamoto K; Shida H; Institute for Virus Research, Kyoto University, Japan.
The viral transactivator proteins Rex and Rev are necessary for the expression of structural proteins of human T-cell leukemia virus type I and human immunodeficiency virus type 1, respectively. Although the interaction of Rex/Rev with a cellular cofactor(s) has been thought to be required for Rex/Rev action, there is


Change in tropism upon immune escape by human immunodeficiency virus.
J Virol. 1995 May;69(5):3167-70. Unique Identifier : AIDSLINE MED/95222771
McKnight A; Weiss RA; Shotton C; Takeuchi Y; Hoshino H; Clapham PR; Chester Beatty Laboratories, Institute of Cancer Research,; London, United Kingdom.
The V3 loop of human immunodeficiency virus type 1 is both a determinant of viral cell tropism and a target for neutralizing antibodies. This relationship was investigated. Selection of a dual-tropic (T cells and macrophages) virus to replicate in CD4+ brain cells results in loss of macrophage tropism and of neutraliz


Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1.
J Virol. 1995 May;69(5):3216-9. Unique Identifier : AIDSLINE MED/95222780
Englund G; Theodore TS; Freed EO; Engleman A; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, Bethesda, Maryland 20892.
Certain human immunodeficiency virus type 1 (HIV-1) isolates are able to productively infect nondividing cells of the monocyte/macrophage lineage. We have used a molecular genetic approach to construct two different HIV-1 integrase mutants that were studied in the context of an infectious, macrophage-tropic HIV-1 mole


A replication-competent, endogenous retrovirus from an aged DBA/2 mouse contains the complete env from Emv-3 and a novel gag partially related to AKT-8.
J Virol. 1995 May;69(5):3224-8. Unique Identifier : AIDSLINE MED/95222782
Bartman T; Murasko DM; Blank KJ; Graduate Program in Molecular Biology and Genetics, Temple; University School of Medicine, Philadelphia, Pennsylvania 19140,; USA.
We previously described an endogenous murine retrovirus, rv-DBA/2aged, isolated from an aged DBA/2 mouse. The previous report showed that a recombination which resulted in the replacement of Emv-3 gag sequences with gag sequences homologous to those found in the AKT-8 virus had taken place. This recombination allowed


Different roles of bases within the integration signal sequence of human immunodeficiency virus type 1 in vitro.
J Virol. 1995 May;69(5):3233-6. Unique Identifier : AIDSLINE MED/95222784
Yoshinaga T; Fujiwara T; Shionogi Institute for Medical Science, Osaka, Japan.
To investigate the roles of bases near the tips of each strand of the long terminal repeat of the human immunodeficiency virus type 1 in the integration reaction, we examined the efficiencies of both binding and integration activities of staggered-ended substrates and mismatched mutant substrates by the integration as


HIV seroprevalence in injection drug users [letter]
JAMA. 1995 Apr 19;273(15):1178. Unique Identifier : AIDSLINE MED/95222855
Watters JK; Bluthenthal RN; Kral AH
Predictors for failure of Pneumocystis carinii pneumonia prophylaxis. Multicenter AIDS Cohort Study.
JAMA. 1995 Apr 19;273(15):1197-202. Unique Identifier : AIDSLINE MED/95222859
Saah AJ; Hoover DR; Peng Y; Phair JP; Visscher B; Kingsley LA; Schrager LK; Johns Hopkins University, School of Public Health, Baltimore,; Md., 21205, USA.
OBJECTIVE--To identify clinical and epidemiological factors associated with failure of Pneumocystis carinii pneumonia (PCP) prophylaxis in those receiving primary and secondary prophylaxis. DESIGN--Longitudinal cohort study of participants infected with human immunodeficiency virus type 1 in the Multicenter AIDS Cohor


[The epidemiology of tuberculosis in El Ferrol (see comments)]
Med Clin (Barc). 1995 Mar 18;104(10):365-8. Unique Identifier : AIDSLINE MED/95222962
Garcia Rodriguez JF; Vazquez Castro J; De Juan Prego J; Rodriguez Mayo M; Sesma Sanchez P; Gonzalez Moraleja J; Servicio de Medicina Interna, Hospital A. Marcide-Novoa Santos,; El Ferrol, La Coruna.
BACKGROUND: This study was undertaken to know the frequency of tuberculosis in El Ferrol and to contribute to the knowledge of the situation in Spain . METHODS: A retrospective study of all the cases of tuberculosis diagnosed in the Hospital A. Marcide-Novoa Santos (El Ferrol, Spain)


[Tumor necrosis factor-alpha in human immunodeficiency virus infection]
Med Clin (Barc). 1995 Mar 18;104(10):369-72. Unique Identifier : AIDSLINE MED/95222963
Llobet P; Muga R; Gonzalez JA; Abad E; Tor J; Rey-Joly C; Servicio de Medicina Interna, Hospital Universitario Germans; Trias i Pujol, Badalona, Barcelona.
BACKGROUND: The aim of the present was to determine the levels of the tumor necrosis factor (TNF)-alpha in patients with HIV infection to study the relationship with the concentration of triglycerides (TG), CD4 lymphocyte count and clinical diagnosis. METHODS: Seventy-eight HIV-infected patients (58 males, 20 females)


Screening for tuberculosis and HIV in resource-poor countries [comment]
Lancet. 1995 Apr 8;345(8954):873-4. Unique Identifier : AIDSLINE MED/95223041
De Cock KM; London School of Hygiene and Tropical Medicine, UK.
Screening for active tuberculosis in HIV testing centre [see comments]
Lancet. 1995 Apr 8;345(8954):890-3. Unique Identifier : AIDSLINE MED/95223048
Espinal MA; Reingold AL; Koenig E; Lavandera M; Sanchez S; Division of Public Health Biology and Epidemiology, School of; Public Health, University of California, Berkeley, USA.
In industrialised nations HIV-seropositive individuals can be offered skin testing for tuberculosis (TB) and isoniazid prophylaxis, but this approach is neither practicable nor affordable in most developing countries. In Santo Domingo,


Patterns of initial and acquired antituberculosis drug resistance in Karonga District, Malawi [see comments]
Lancet. 1995 Apr 8;345(8954):907-10. Unique Identifier : AIDSLINE MED/95223054
Glynn JR; Jenkins PA; Fine PE; Ponnighaus JM; Sterne JA; Mkandwire PK; Nyasulu S; Bliss L; Warndorff DK; Communicable Disease Epidemiology Unit, London School of Hygiene; and Tropical Medicine, UK.
There is concern that drug-resistant tuberculosis is increasing and may be concentrated among HIV-positive patients. Little information is available from developing countries, where surveillance studies are often unable to distinguish resistance in previously untreated patients (initial resistance) from resistance acq


The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.
Microbiol Rev. 1995 Mar;59(1):63-93. Unique Identifier : AIDSLINE MED/95223266
Bour S; Geleziunas R; Wainberg MA; McGill AIDS Centre, Lady Davis Institute-Jewish General Hospital,; Montreal, Quebec, Canada.
Interactions between the viral envelope glycoprotein gp120 and the cell surface receptor CD4 are responsible for the entry of human immunodeficiency virus type 1 (HIV-1) into host cells in the vast majority of cases. HIV-1 replication is commonly followed by the disappearance or receptor downmodulation of cell surface


Testing for HIV infection at home [see comments]
N Engl J Med. 1995 May 11;332(19):1296-9. Unique Identifier : AIDSLINE MED/95223338
Bayer R; Stryker J; Smith MD; Columbia University School of Public Health, New York, NY 10032,; USA.
Potential use of home HIV testing [comment]
N Engl J Med. 1995 May 11;332(19):1308-10. Unique Identifier : AIDSLINE MED/95223350
Phillips KA; Flatt SJ; Morrison KR; Coates TJ; University of California, San Francisco 94105, USA.
Gene therapy. AIDS advance [news]
Nursing. 1995 Jan;25(1):52. Unique Identifier : AIDSLINE MED/95223586
HIV testing. Tracking test [news]
Nursing. 1995 Jan;25(1):9. Unique Identifier : AIDSLINE MED/95223596
HIV and cancer: a direct link? [news]
Nursing. 1995 Apr;25(4):47. Unique Identifier : AIDSLINE MED/95223620
Self-test. Caring for AIDS patients.
Nursing. 1995 Apr;25(4):76-8. Unique Identifier : AIDSLINE MED/95223632
Lewis J; Doyle K; Sampson D
[In vitro synergic lymphocyte stimulation in HIV-1 infected patients using inosine derivatives and radio-detoxified endotoxin]
Orv Hetil. 1995 Mar 19;136(12):653-9. Unique Identifier : AIDSLINE MED/95223665
Ongradi J; Hadden JW; Bertok L; Specter S; Nelson R; Friedman H; Mikrobiologiai Intezet, Semmelweis Orvostudomanyi Egyetem,; Budapest.
Restoration of immune functions through promoting cell cycle might delay acquired immunodeficiency syndrome development. Therefore, stimulation of peripheral lymphocytes of human immunodeficiency virus-1 infected patients in successive clinical stages was studied by phytohaemagglutinin and other stimulants. In vitro b


AIDS and dilated cardiomyopathy [letter]
Postgrad Med J. 1995 Jan;71(831):59. Unique Identifier : AIDSLINE MED/95223895
Odeh M
ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2484-8. Unique Identifier : AIDSLINE MED/95223965
Kempf DJ; Marsh KC; Denissen JF; McDonald E; Vasavanonda S; Flentge CA; Green BE; Fino L; Park CH; Kong XP; et al; Department of Anti-Infective Research, Abbott Laboratories,; Abbott Laboratories, Abbott Park, IL 60064, USA.
Examination of the structural basis for antiviral activity, oral pharmacokinetics, and hepatic metabolism among a series of symmetry-based inhibitors of the human immunodeficiency virus (HIV) protease led to the discovery of ABT-538, a promising experimental drug for the therapeutic intervention in acquired immunodefi


Human autoantibody recognition of DNA.
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2529-33. Unique Identifier : AIDSLINE MED/95223974
Barbas SM; Ditzel HJ; Salonen EM; Yang WP; Silverman GJ; Burton DR; Department of Immunology, Scripps Research Institute, La Jolla,; CA 92037, USA.
Combinatorial IgG Fab phage display libraries prepared from a systemic lupus erythematosus (SLE) donor and a healthy donor were affinity selected against human placental DNA. Human monoclonal antibody Fab fragments specific for DNA were isolated from both libraries, although Fabs of the highest affinity were isolated


Combination gene therapy for liver metastasis of colon carcinoma in vivo.
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2577-81. Unique Identifier : AIDSLINE MED/95223984
Chen SH; Chen XH; Wang Y; Kosai K; Finegold MJ; Rich SS; Woo SL; Howard Hughes Medical Institute, Baylor College of Medicine,; Houston, TX 77030, USA.
The efficacy of combination therapy with a suicide gene and a cytokine gene to treat metastatic colon carcinoma in the liver was investigated. Tumor in the liver was generated by intrahepatic injection of a colon carcinoma cell line (MCA-26) in syngeneic BALB/c mice. R


Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2755-9. Unique Identifier : AIDSLINE MED/95224019
Weiner A; Erickson AL; Kansopon J; Crawford K; Muchmore E; Hughes AL; Houghton M; Walker CM; Chiron Corporation, Emeryville, CA 94608, USA.
Hepatitis C virus (HCV) establishes a persistent infection in humans and chimpanzees despite the presence of virus-specific, class I major histocompatibility complex-restricted CD8+ cytotoxic T lymphocytes (CTLs) in the liver. The data presented here demonstrate that CTLs directed against a conserved epitope in the HC


A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects.
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2770-4. Unique Identifier : AIDSLINE MED/95224022
Macreadie IG; Castelli LA; Hewish DR; Kirkpatrick A; Ward AC; Azad AA; Biomolecular Research Institute, Parkville, Victoria, Australia.
Vpr is a virion-associated protein of human immunodeficiency type 1 (HIV-1) whose function in acquired immunodeficiency syndrome (AIDS) has been uncertain. Employing the yeast Saccharomyces cerevisiae as a model to examine the effects of HIV-1 auxiliary proteins on basic cellular functions, we found that the vpr gene


Generation of cytotoxic and humoral immune responses by nonreplicative recombinant Semliki Forest virus.
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3009-13. Unique Identifier : AIDSLINE MED/95224069
Zhou X; Berglund P; Zhao H; Liljestrom P; Jondal M; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.
The Semliki Forest virus (SFV) expression system can be used to package recombinant RNA into infectious suicide particles. Such RNA encodes only the SFV replicase and the heterologous protein but no structural proteins of SFV, and it is thus deficient in productive replication. We demonstrate here that infection of C5


Retinoic acid inhibition of ex vivo human immunodeficiency virus-associated apoptosis of peripheral blood cells.
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3051-5. Unique Identifier : AIDSLINE MED/95224077
Yang Y; Bailey J; Vacchio MS; Yarchoan R; Ashwell JD; Laboratory of Immune Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892, USA.
T cells from human immunodeficiency virus (HIV)-infected individuals undergo spontaneous and activation-induced ex vivo apoptosis. Here we report that peripheral blood mononuclear cells (PBMCs) obtained from six HIV-infected individuals exhibited reduced ex vivo DNA fragmentation and cell death after ingestion of all-


A student-centred approach to learning. An HIV and AIDS awareness elective.
Prof Nurse. 1995 Feb;10(5):282-3. Unique Identifier : AIDSLINE MED/95224086
Peate I
1. Central to the philosophy of the elective module is the belief that students have individual specific needs and bring with them a wealth of knowledge and experience. 2. Electives encourage a strong sense of self-confidence in students. 3. Developing a curriculum that comprises a portfolio of meaningful personal exp


A question of prejudice. Stigma, homosexuality and HIV/AIDS.
Prof Nurse. 1995 Mar;10(6):380-3. Unique Identifier : AIDSLINE MED/95224102
Peate I
1. Nurses will, in the future, be faced with caring for a growing number of people with HIV and Aids, including both heterosexual and homosexual patients. 2. People infected with HIV may remain asymptomatic for long periods, and are capable of transmitting the virus. 3. Our value and belief systems may not be the same


Evolution of mutation rate and virulence among human retroviruses.
Philos Trans R Soc Lond B Biol Sci. 1994 Nov 29;346(1317):333-41; discussion 341-3. Unique Identifier : AIDSLINE MED/95224134
Ewald PW; Department of Biology, Amherst College, Massachusetts 01002-5000.
High mutation rates are generally considered to be detrimental to the fitness of multicellular organisms because mutations untune finely tuned biological machinery. However, high mutation rates may be favoured by a need to evade an immune system that has been strongly stimulated to recognize those variants that reprod


After epidemiological research: what next? Community action for health promotion.
Public Health Rev. 1994;22(3-4):375-94. Unique Identifier : AIDSLINE MED/95224262
Cwikel JG; Charlotte & Jack Spitzer Department of Social Work, Ben-Gurion; University of the Negev, Beer Sheva, Israel.
The underlying purpose of all epidemiological research is ultimately to use inferences in order to prevent disease and promote health and well-being. Effective skills in translating results into appropriate policy, programs, and interventions are inherently tricky, and often politically controversial. Generally they a


Analysis of bronchoalveolar lavage from human lung transplant recipients by flow cytometry.
Respir Med. 1995 Jan;89(1):27-34. Unique Identifier : AIDSLINE MED/95224294
Whitehead BF; Stoehr C; Finkle C; Patterson G; Theodore J; Clayberger C; Starnes VA; Department of Cardiothoracic Surgery, Stanford University Medical; Centre, California 94305, USA.
Bronchoalveolar lavage (BAL) cells and peripheral blood leucocytes (PBL) from 24 lung transplant recipients were analysed for leucocyte subsets and expression of cell surface antigens. Total and differential white cell counts were performed on BAL, and lymphocyte subsets were evaluated in both BAL and peripheral blood


[Preventive measures by physicians and nurses in the Flor Crombet outfit]
Rev Cubana Enferm. 1993 Jan-Jun;9(1):16-21. Unique Identifier : AIDSLINE MED/95224328
Williams Kindelan I; Fernandez Charon E; Garcia Martinez C; Bridon Romero L
A study was conducted en 100 workers from Flor Crombet Contingent in Yateras municipality, province of Guantanamo. Ninety-six men and 4 women out of 100 workers studied had health certificates, most of them made by nurses or physicians, thus sparing the need to go to a polyclinic and saving working hours. When visitin


[Cutaneous tuberculosis: a case of difficult classification]
Recenti Prog Med. 1995 Jan;86(1):21-4. Unique Identifier : AIDSLINE MED/95224355
Rotoli M; Capizzi R; Carlesimo F; Celleno L; Cavalieri S; Clinica Dermatologica, Universita Cattolica del Sacro Cuore,; Roma.
We describe a case of cutaneous tuberculosis in a 25-year-old Philippine man. Erythematous papulo-nodular lesions, measuring 0.5 to 1 cm, were present on lower limbs; a 2 cm nodule was located on the left flank. The examination of the skin biopsy showed the presence of a superficial and deep perivascular dermatitis wi


[The diagnosis of viral infections in the central nervous system in AIDS and related pathologies by the polymerase chain reaction in the cerebrospinal fluid]
Recenti Prog Med. 1995 Jan;86(1):26. Unique Identifier : AIDSLINE MED/95224357
Garavelli PL; Divisione di Malattie Infettive, Ospedale Civile, Alessandria.
Differential effects of ras and jun family members on complex retrovirus promoter activities.
Res Virol. 1994 Nov-Dec;145(6):361-7. Unique Identifier : AIDSLINE MED/95224393
Mercier G; Galien R; Emanoil-Ravier R; Laboratoire des Retrovirus et Retrotransposons des Vertebres,; UPR 0043 CNRS, Hopital Saint-Louis, Paris.
Infection by complex retroviruses such as Visna-maedi, HIV1, HTLV-I and HFV is generally not followed by particle production, but rather by a more or less prolonged latency period. Knowledge of the mechanisms triggering an infectious cycle from the latent provirus(es) is of great importance in comprehending the appear


Rapid and constant detection of HIV antibody response in saliva of HIV-infected patients; selective distribution of anti-HIV activity in the IgG isotype.
Res Virol. 1994 Nov-Dec;145(6):369-77. Unique Identifier : AIDSLINE MED/95224394
Lu XS; Delfraissy JF; Grangeot-Keros L; Rannou MT; Pillot J; Service de Microbiologie et d'Immunologie, Hopital Antoine; Beclere, Clamart, France.
Anti-HIV antibodies can be specifically detected with a sensitivity and a specificity of 100% in the saliva of all HIV-infected patients. A saliva collection device facilitates the sampling procedure, and if a rapid test is used, the diagnosis of infection can be established in as little as 10 min. The analysis of a g


Evaluation of the amplicor HIV1 DNA diagnosis test.
Res Virol. 1994 Nov-Dec;145(6):393-5. Unique Identifier : AIDSLINE MED/95224397
Poussin K; Harter-Chaput A; Sayada C; Brechot C; INSERM U370, Faculte de Medecine, Hopital Necker, Paris,; France.
Animal lentivirus- and HIV1-induced cytopathicity.
Res Virol. 1994 Nov-Dec;145(6):407-8. Unique Identifier : AIDSLINE MED/95224399
Di Guardo G
Central nervous system vasculitis secondary to infections, toxins, and neoplasms.
Semin Neurol. 1994 Dec;14(4):313-9. Unique Identifier : AIDSLINE MED/95224403
Giang DW; Department of Neurology, University of Rochester Medical Center,; New York, USA.
[Disseminated Mycobacterium avium complex infections in AIDS. Apropos of 100 cases. Groupe d'Epidemiologie clinique du SIDA en Aquitaine]
Rev Med Interne. 1995;16(2):110-20. Unique Identifier : AIDSLINE MED/95224422
Lasseur C; Maugein J; Pellegrin JL; Dupon M; Ragnaud JM; Morlat P; Pellegrin I; Constans J; Monlun E; Chene G; et al; Groupe d'Epidemiologie clinique du sida en Aquitaine, Hopital; Haut-Leveque, CHU Bordeaux, Pessac, France.
The improvement of survival of AIDS patients allowed the emergence of disseminated Mycobacterium avium Complex infections (D.MAC). Here we report the experience of the group of Epidemiologie clinique du sida en Aquitaine (GECSA) about 100 patients. There were no differences according to sex, age and route of acquisiti


[Disseminated Mycobacterium bovis tuberculosis in an aged female patient without HIV infection]
Rev Med Interne. 1995;16(2):143-5. Unique Identifier : AIDSLINE MED/95224427
Dumars A; Roblot P; Burucoa C; Roblot F; Breton I; Becq-Giraudon B; Service de Medecine Interne et Maladies Infectieuses, CHU La; Miletrie, Poitiers, France.
The authors report the case of a woman affected by disseminated infection caused by Mycobacterium bovis, without risk exposure and immunodeficiency. There were chest and urinary localisations and bacteremia. Usually, M bovis is responsible of chest tuberculosis, in patients with professional exposure. Disseminated for


[Mycobacterium avium complex (editorial)]
Rev Med Interne. 1995;16(2):99-101. Unique Identifier : AIDSLINE MED/95224435
Leclerc H
Ethics in action. A nurse is told by a friend that a colleague on her neonatal intensive care unit is HIV-positive.
RN. 1995 Mar;58(3):14-6. Unique Identifier : AIDSLINE MED/95224462
Haddad A
An HIV battle plan.
RN. 1995 Mar;58(3):18-21. Unique Identifier : AIDSLINE MED/95224463
The CDC moves to consolidate the HIV/AIDS fight [news]
RN. 1995 Mar;58(3):9. Unique Identifier : AIDSLINE MED/95224470
[Practice and needs of Swiss physicians in matters of prevention of HIV infection in their office--experience, reflections and recommendations]
Schweiz Med Wochenschr. 1995 Apr 1;125(13):621-6. Unique Identifier : AIDSLINE MED/95224502
Meystre-Agustoni G; Dubois-Arber F; Gruninger U; Cassis I; Jeannin A; Institut Universitaire de Medecine Sociale et Preventive,; Lausanne.
General practitioners play an important role in HIV/AIDS prevention. They are expected to take patients risk histories, to assess gaps in knowledge and preventive behaviours, and to practise individualised counselling. This article reviews research conducted between 1988 and 1994 on preventive activities of Swiss gen


[Primary HIV infection: an often suspected diagnosis but confirmed late]
Schweiz Med Wochenschr. 1995 Feb 25;125(8):341-6. Unique Identifier : AIDSLINE MED/95224507
Galetto-Lacour A; Kinloch-de Loes S; Hirschel B; Perrin L; Laboratoire central de virologie, Hopital cantonal universitaire; de Geneve, HCUG.
We report the history and clinical findings in 17 patients with primary HIV infection (PHI) diagnosed in the first 6 months of 1994. 9 of these patients were infected through heterosexual contacts, 5 were women with, as the only risk factor, sexual contacts with infected men. 10 of the 17 patients were symptomatic and


Health care worker protection: it is more than HIV.
Urol Nurs. 1994 Jun;14(2):48-51. Unique Identifier : AIDSLINE MED/95224565
Lerner CJ
Is the 1993/94 AIDS budget adequate? [letter]
S Afr Med J. 1994 Jul;84(7):447. Unique Identifier : AIDSLINE MED/95224640
The cost of adult AIDS inpatient care [letter]
S Afr Med J. 1994 Jul;84(7):447, 449. Unique Identifier : AIDSLINE MED/95224642
Peter DL; McDougall M; Maartens G; Girdler-Brown BV
Myelopathy in a patient dually infected with HIV-1 and HTLV-I [letter]
S Afr Med J. 1994 Jul;84(7):451-2. Unique Identifier : AIDSLINE MED/95224645
Steele AD; Hasan A; du Toit D; Fripp PJ; Lecatsas G; Joubert J
Hospital-based study of sexually transmitted diseases at Murewa rural district hospital, Zimbabwe 1991-1992.
Sex Transm Dis. 1995 Jan-Feb;22(1):1-6. Unique Identifier : AIDSLINE MED/95224649
Tswana SA; Nystrom L; Moyo SR; Blomberg J; Tianani J; Nzara M; Chieza L; Department of Medical Microbiology, University of Zimbabwe,; Harare.
BACKGROUND AND OBJECTIVES: In Zimbabwe , sexually transmitted diseases are highly prevalent and represent a significant amount of the workload for physicians. GOAL OF THIS STUDY: To estimate the prevalence of sexually transmitted diseases and human immunodeficiency virus as well a


Condom use to prevent incident STDs: the validity of self-reported condom use.
Sex Transm Dis. 1995 Jan-Feb;22(1):15-21. Unique Identifier : AIDSLINE MED/95224650
Zenilman JM; Weisman CS; Rompalo AM; Ellish N; Upchurch DM; Hook EW 3rd; Celentano D; Division of Infectious Diseases, Johns Hopkins University School; of Medicine, Baltimore, MD 21205-2196.
BACKGROUND: Studies of sexual behavior and of interventions designed to reduce human immunodeficiency virus risk usually depend on self-report. Validation of self-reported condom use measures has not been previously reported in an urban population at high risk for sexually transmitted diseases and human immunodeficien


Association between reproductive tract infections and cervical inflammatory epithelial changes.
Sex Transm Dis. 1995 Jan-Feb;22(1):25-30. Unique Identifier : AIDSLINE MED/95224652
Singh V; Gupta MM; Satyanarayana L; Parashari A; Sehgal A; Chattopadhya D; Sodhani P; Institute of Cytology and Preventive Oncology, Maulana Azad; Medical College Campus, New Delhi, India.
OBJECTIVE: To determine the association, if any, between different reproductive tract infections and cervical inflammatory epithelial changes. STUDY DESIGN: Clinical, colposcopic, cytologic, and microbiologic screening for reproductive tract infections was conducted. Subjects were screened for Chlamydia trachomatis, N


Anal human papillomavirus infection among homosexual and bisexual men: prevalence of type-specific infection and association with human immunodeficiency virus.
Sex Transm Dis. 1995 Jan-Feb;22(1):7-14. Unique Identifier : AIDSLINE MED/95224659
Breese PL; Judson FN; Penley KA; Douglas JM Jr; Department of Public Health, Denver Health and Hospitals,; Colorado.
BACKGROUND AND OBJECTIVE: High-risk types of genital human papillomavirus (HPV) infections are associated with anogenital cancer. As these cancers occur more frequently in immunosuppressed individuals, we sought to better characterize type-specific prevalence, clinical spectrum, and risk factors for anal HPV infection


[Retroviral molecular biology--possibilities of gene therapy?]
Ugeskr Laeger. 1995 Mar 6;157(10):1332-4. Unique Identifier : AIDSLINE MED/95224819
Lund BO; Nielsen JO; Hansen JS; Infektionsmedicinsk laboratorium afdeling, Hvidovre Hospital,; Kobenhavn.
[AIDS in Denmark. 1. Opportunistic infections and malignant diseases. Danish Study Group for HIV infection]
Ugeskr Laeger. 1995 Mar 6;157(10):1347-51. Unique Identifier : AIDSLINE MED/95224823
Lundgren JD; Bentsen KD; Pedersen C; Gerstoft J; Seefeldt-Nielsen T; Nielsen TL; Jensen GF; Infektionsmedicinsk afdeling, Hvidovre Hospital, Kobenhavn.
To examine the distribution of AIDS-defining illnesses among Danish AIDS patients, data on 687 AIDS patients diagnosed in the period from 1980 to 1990 (93% of all reported cases in the period) were collected. The most frequent AIDS-defining illness was Pneumocystis carinii pneumonia followed by candida oesophagitis an


[AIDS in Denmark. 2. Survival after the diagnosis of AIDS. Danish Study Group for HIV infection]
Ugeskr Laeger. 1995 Mar 6;157(10):1352-6. Unique Identifier : AIDSLINE MED/95224824
Lundgren JD; Pedersen C; Bentsen KD; Gerstoft J; Seefeldt-Nielsen T; Nielsen TL; Jensen GF; Infektionsmedicinsk afdeling, Hvidovre Hospital, Kobenhavn.
The survival pattern was studied for 687 Danish AIDS patients (93% of notified cases in the study period) who were diagnosed with AIDS during the period from 1980 to 1990. The median survival was 17 months. Factors significantly associated with a shortened survival were transfusion-acquired HIV infection, age > 40 yea


Serological and haematological diagnosis of enzootic bovine leukosis in cattle in Turkey.
Vet Rec. 1995 Jan 14;136(2):42-4. Unique Identifier : AIDSLINE MED/95224914
Batmaz H; Carli KT; Kahraman M; Cetin C; Kennerman E; Faculty of Veterinary Medicine, University of Uludag, Gorukle,; Bursa, Turkey.
A serological study of enzootic bovine leukosis in the Bursa Region of Turkey showed that of 459 cattle (282 Holstein, 127 Brown-Swiss and 50 native Boz breed) 42 (9.15 per cent) were seropositive. The seropositive cattle had higher IgG1 (P


[Activation of the major omentum-associated lymphoid tissue in Crohn disease]
Zentralbl Chir. 1995;120(2):135-44. Unique Identifier : AIDSLINE MED/95225009
Schreiber S; Gehrckens A; Raedler A; Medizinische Kernklinik und Poliklinik, Universitatskrankenhaus; Eppendorf Universitat Hamburg.
The mucosa associated lymphoid tissues of the intestinal lamina propria or the bronchial mucosa, respectively, represent a separated and well defined immunologic compartment. Due to highly specialized functions, subpopulations of lymphoid cells are distributed unevenly between the compartments and unique regulatory me


Concurrent herpes simplex type 1 necrotizing encephalitis, cytomegalovirus ventriculoencephalitis and cerebral lymphoma in an AIDS patient.
Acta Neuropathol (Berl). 1995;89(1):105-8. Unique Identifier : AIDSLINE MED/95225068
Vital C; Monlun E; Vital A; Martin-Negrier ML; Cales V; Leger F; Longy-Boursier M; Le Bras M; Bloch B; Department of Neuropathology, Bordeaux II University, France.
Unlike cytomegalovirus ( CMV ) ventriculoencephalitis, herpes simplex virus type 1 necrotizing encephalitis has only rarely been observed in AIDS patients. A 40-year-old bisexual man was followed for an HIV1 infection from 1987


Follicular dendritic cells (FDC) are not productively infected with HIV-1 in vivo.
Adv Exp Med Biol. 1994;355:165-8. Unique Identifier : AIDSLINE MED/95225169
Schmitz J; van Lunzen J; Tenner-Racz K; Grossschupff G; Racz P; Schmitz H; Dietrich M; Hufert F; Department of Virology, Bernhard Nocht Institute, Hamburg,; Germany.
Lymph node pathology in experimental FIV infection.
Adv Exp Med Biol. 1994;355:169-75. Unique Identifier : AIDSLINE MED/95225170
Callanan JJ; Racz P; Thompson H; Jarrett O; Department of Veterinary Pathology, University of Glasgow,; Bearsden, Scotland.
Lymphocyte lifespan in murine retrovirus-induced immunodeficiency.
Adv Exp Med Biol. 1994;355:177-81. Unique Identifier : AIDSLINE MED/95225171
Moutschen M; Colombi S; Deprez M; Greimers R; Van Wijk F; Hotermans C; Boniver J; Department of Pathology, CHU Sart-Tilman, Liege, Belgium.
Analysis of HIV infections in human macrophage-like cell lines.
Adv Exp Med Biol. 1994;355:183-7. Unique Identifier : AIDSLINE MED/95225172
Brys L; Van Gyseghem A; Verhaegen S; Saman E; De Baetselier P; Instituut voor Moleculaire Biologie, Vrije Universiteit Brussel.
Development of components of the mucosal immune system in SCID recipient mice.
Adv Exp Med Biol. 1994;355:255-9. Unique Identifier : AIDSLINE MED/95225185
Cebra JJ; Bos NA; Cebra ER; Cuff CF; Deenen GJ; Kroese FG; Shroff KE; Department of Biology, University of Pennsylvania, Philadelphia; 19104-6018.
Lessons from AIDS.
Ala Med. 1995 Feb;64(8):23-4. Unique Identifier : AIDSLINE MED/95225233
Campbell ES
AAP statement on perinatal HIV testing [news]
Am Fam Physician. 1995 Apr;51(5):1316. Unique Identifier : AIDSLINE MED/95225254
Historical assessment of some specific methods for projecting the AIDS epidemic.
Am J Epidemiol. 1995 Apr 15;141(8):776-81. Unique Identifier : AIDSLINE MED/95225278
Bacchetti P; Department of Epidemiology and Biostatistics, University of; California, San Francisco 94143-0840, USA.
Extrapolation and back-calculation methods for predicting future acquired immunodeficiency syndrome (AIDS) incidence are assessed by examining how they would have performed at various points in the past. The methods use monthly AIDS diagnosis counts through December 1991 for all adults and adolescents in the


Re: Factors associated with survival in human immunodeficiency virus-infected patients with very low CD4 counts [letter; comment]
Am J Epidemiol. 1995 Apr 15;141(8):788-9. Unique Identifier : AIDSLINE MED/95225280
Vanhems P; Allard R
Itraconazole treatment of disseminated histoplasmosis in patients with the acquired immunodeficiency syndrome. AIDS Clinical Trial Group.
Am J Med. 1995 Apr;98(4):336-42. Unique Identifier : AIDSLINE MED/95225302
Wheat J; Hafner R; Korzun AH; Limjoco MT; Spencer P; Larsen RA; Hecht FM; Powderly W; Department of Medicine, Indiana University, Indianapolis, USA.
PURPOSE: Amphotericin B has been the treatment of choice for disseminated histoplasmosis in patients with acquired immunodeficiency syndrome (AIDS). Oral antifungal agents would be welcome alternatives to standard treatment of disseminated histoplasmosis in less severe cases. The purpose of this study was to assess th


Aerosolized pentamidine prophylaxis of Pneumocystis carinii pneumonia [letter; comment] [published erratum appears in Am J Med 1995 Jun;98(6):602]
Am J Med. 1995 Apr;98(4):422-3. Unique Identifier : AIDSLINE MED/95225321
Wilkinson SB
Phase I/II study of intravitreal cidofovir for the treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome.
Am J Ophthalmol. 1995 Apr;119(4):466-76. Unique Identifier : AIDSLINE MED/95225331
Kirsch LS; Arevalo JF; De Clercq E; Chavez de la Paz E; Munguia D; Garcia R; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California at San Diego, La Jolla 92093-0946, USA.
PURPOSE: In this study we evaluated the safety and efficacy of the nucleoside phosphonate analogue intravitreal cidofovir to treat cytomegalovirus retinitis in humans. METHODS: We conducted a phase I/II unmasked consecutive case series in a single-center institutional referral prac


Treatment of progressive outer retinal necrosis with sorivudine.
Am J Ophthalmol. 1995 Apr;119(4):516-7. Unique Identifier : AIDSLINE MED/95225340
Pinnolis MK; Foxworthy D; Kemp B; Visual Services Department, Massachusetts Eye and Ear Infirmary,; Boston 02114, USA.
PURPOSE/METHODS: We examined a patient with progressive outer retinal necrosis, which is presumably caused by the varicella-zoster virus in patients with the acquired immunodeficiency syndrome. RESULTS/CONCLUSIONS: The patient was successfully treated with a combination of intravitreal ganciclovir and oral sorivudine.


Dissemination of HIV: how serious is it for women, medically and psychologically?
Ann N Y Acad Sci. 1994 Dec 30;736:114-21. Unique Identifier : AIDSLINE MED/95225569
Cohen MA; Alfonso CA; Metropolitan Hospital Center, New York Medical College, New York; 10029, USA.
Women's health and the articulation of policy preferences. Setting the terms of discussion.
Ann N Y Acad Sci. 1994 Dec 30;736:205-16. Unique Identifier : AIDSLINE MED/95225580
Griffin A; Faculty of Humanities and Social Sciences, Cooper Union for the; Advancement of Science and Art, New York, New York 10003, USA.
Anaesthesia for the patient with acquired immune deficiency syndrome--a review.
Ann Acad Med Singapore. 1994 Nov;23(6 Suppl):14-9. Unique Identifier : AIDSLINE MED/95225597
Frost EA; Department of Anesthesiology, New York Medical College, Valhalla; 10595, USA.
Acquired immunodeficiency syndrome affects over 10 million persons worldwide. The disease represents an enormous cost to society in health care resources and in loss from the workforce. Although initially reported in 1980 as a disease affecting mainly homosexuals and intravenous drug abusers with a predominance in mal


Haemoglobin-based blood substitutes: what's on the horizon?
Ann Acad Med Singapore. 1994 Nov;23(6 Suppl):71-6. Unique Identifier : AIDSLINE MED/95225612
Dietz NM; Joyner MJ; Department of Anesthesiology, Mayo Clinic and Foundation,; Rochester, MN 55905, USA.
Military and civilian medical organisations have long recognised that an oxygen-carrying volume expander which is easy to store, transport and administer could be life-saving for trauma victims. Concern over fatal blood-borne pathogens including hepatitis and human immunodeficiency virus (HIV), as well as a shrinking


Treatment of acyclovir-unresponsive cutaneous herpes simplex virus infection with topically applied SP-303.
Antiviral Res. 1994 Dec;25(3-4):185-92. Unique Identifier : AIDSLINE MED/95225642
Safrin S; McKinley G; McKeough M; Robinson D; Spruance SL; Department of Medicine, University of California San Francisco,; USA.
The naturally occurring polyphenolic biopolymer SP-303 has in vitro activity against both HSV-1 and HSV-2, including strains that are resistant to acyclovir . Nine AIDS patients with acyclovir-unresponsive mucocutaneous herpes simplex virus infection were treated with thrice dail


HIV proteinase inhibitors containing 2-aminobenzylstatine as a novel scissile bond replacement: biochemical and pharmacological characterization.
Antiviral Res. 1994 Dec;25(3-4):215-33. Unique Identifier : AIDSLINE MED/95225645
Billich A; Charpiot B; Fricker G; Gstach H; Lehr P; Peichl P; Scholz D; Rosenwirth B; Sandoz Forschungsinstitut, Vienna, Austria.
Derivation of the 2-aminobenzylstatine containing HIV-1 proteinase (PR) inhibitor I led to a series of compounds with considerably improved antiviral activity, the most potent derivatives inhibiting HIV-1 with IC50 values below 25 nM. This was achieved by the combination of several structural modifications, most promi


Identification of drug-related genotypic changes in HIV-1 from serum using the selective polymerase chain reaction.
Antiviral Res. 1994 Dec;25(3-4):245-58. Unique Identifier : AIDSLINE MED/95225647
Anderson BD; Shirasaka T; Kojima E; Yarchoan R; Mitsuya H; Experimental Retrovirology Section, National Cancer Institute,; Bethesda, MD 20892, USA.
We attempted to detect drug-related HIV-1 pol gene mutations by selective polymerase chain reaction (PCR) using both proviral DNA and viral RNA isolated from patients (pts) with AIDS or ARC receiving antiretroviral therapy. Peripheral blood mononuclear cell (PBM)-associated proviral DNA and serum-derived viral RNA wer


A BK virus episomal vector for constitutive high expression of exogenous cDNAs in human cells.
Arch Virol. 1995;140(2):335-9. Unique Identifier : AIDSLINE MED/95225750
Sabbioni S; Negrini M; Rimessi P; Manservigi R; Barbanti-Brodano G; Institute of Microbiology, School of Medicine, University of; Ferrara, Italy.
A BK virus (BKV) episomal vector (pRPneoCMV) was constructed for expression of cDNAs under control of the cytomegalovirus (CMV) immediate-early promoter. Transfection of pRPneoCMV for expression of the chloramphenicol acetyltransferase (CAT) gene in several human cell lines showed


Detection of the cellular membrane proteins on human T cell leukemia virus type I.
Arch Virol. 1995;140(2):375-82. Unique Identifier : AIDSLINE MED/95225755
Akari H; Goto Y; Shinjo T; Department of Veterinary Microbiology, Faculty of Agriculture,; Miyazaki University, Japan.
The presence of cellular membrane proteins on human T cell leukemia virus type I (HTLV-I) was examined. ICAM-1 and MHC-IIDR, which were highly expressed on MT-2 cells but not on MOLT-4#8 cells, became detectable on HTLV-I-binding MOLT-4#8 cells. Furthermore, a batch of other cellular molecules including LFA-1, ICAM-1,


Pharmacokinetics of interferon-alpha in pregnant women and fetoplacental passage.
Fetal Diagn Ther. 1995 Jan-Feb;10(1):7-10. Unique Identifier : AIDSLINE MED/95225973
Pons JC; Lebon P; Frydman R; Delfraissy JF; Department of Obstetrics and Gynecology, Cochin-Port Royal; Hospital, Kremlin-Bicetre, France.
Interferon (IFN) therapy is currently not approved for use during pregnancy. Two HIV-seropositive pregnant women, who were due to undergo abortion in the second trimester of pregnancy, were given a single intramuscular dose of IFN-alpha, with their informed consent. Blood samples were taken simultaneously from the mot


Atopic allergy and other hypersensitivities [editorial]
Curr Opin Immunol. 1994 Dec;6(6):835-7. Unique Identifier : AIDSLINE MED/95225998
de Vries JE; DNAX Rearch Institute, CA, USA.
Regulation of the development of type 2 T-helper cells in allergy.
Curr Opin Immunol. 1994 Dec;6(6):838-46. Unique Identifier : AIDSLINE MED/95225999
Romagnani S; University of Florence, Division of Clinical Immunology and; Allergy, Italy.
In the last few years evidence has been accumulated to suggest that allergen-reactive type 2 T helper (Th2) cells play a triggering role in the activation and/or recruitment of IgE antibody-producing B cells, mast cells and eosinophils, the cellular triad involved in the allergic inflammation. Interleukin (IL)-4 produ


Induction of non-responsiveness in human allergen-specific type 2 T helper cells.
Curr Opin Immunol. 1994 Dec;6(6):847-52. Unique Identifier : AIDSLINE MED/95226000
Yssel H; Fasler S; Lamb J; de Vries JE; DNAX Research Institute of Molecular and Cellular Biology, Palo; Alto.
Activation of allergen-reactive human T helper (Th)2 cells in the absence of professional antigen-presenting cells, induces non-responsiveness or anergy in these cells in vitro. This induction of anergy is accompanied by phenotypic modulation and altered cytokine production. Furthermore, peptide-treated Th2 cells fail


A homologue of the human MSS1 gene, a positive modulator of HIV-1 gene expression, is massively expressed in Xenopus oocytes.
Biochim Biophys Acta. 1995 Apr 4;1261(2):293-5. Unique Identifier : AIDSLINE GENBANK/X80157
Nacken W; Kingsman AJ; Kingsman SM; Sablitzky F; Sorg C; Institute for Experimental Dermatology, Munster Medical School,; Germany.
Here the nucleotide sequence of a Xenopus homologue of the human MSS1 gene, a positive modulator of the HIV-1 Tat mediated transactivation in mammalian cells, is presented. This gene is highly conserved and almost exclusively expressed in Xenopus oocytes. We speculate about a possible role of this gene in the HIV-1 Ta


Maternal health in the age of AIDS: implications for health services in developing countries.
AIDS Care. 1994;6(5):499-516. Unique Identifier : AIDSLINE MED/95226469
Preble EA; Elias CJ; Winikoff B; AIDS Control and Prevention (AIDSCAP) Project, Family Health; International, Arlington, Virginia 22201.
In developing countries, the HIV/AIDS epidemic will have a major impact on all phases of women s reproductive lives, and will alter many standard approaches to the management of MCH (maternal and child health) services related to fertility regulation, pregnancy, delivery and the postpartum period. AIDS-related increas


Destinations unknown: the gender construction and changing nature of the sexual expressions of Thai youth.
AIDS Care. 1994;6(5):517-31. Unique Identifier : AIDSLINE MED/95226470
Ford NJ; Kittisuksathit S; Institute of Population Studies, University of Exeter, Devon, UK.
This paper discusses qualitative findings from a study of the sexual awareness, lifestyles and related health service needs of young, single factory workers in Thailand . The context of this study is Thailand s growing industrialization, the deepening intensity of the threats to s


Sexual behaviour of gay and bisexual men in eight European countries.
AIDS Care. 1994;6(5):533-49. Unique Identifier : AIDSLINE MED/95226471
Bochow M; Chiarotti F; Davies P; Dubois-Arber F; Dur W; Fouchard J; Gruet F; McManus T; Markert S; Sandfort T; et al; EC-Concerted Action on AIDS/HIV Prevention Strategies, Working; Group on Homo-Bisexual Men, University of Lousanne-IUMSP,; Switzerland.
To compare the sexual behaviour and HIV risk reduction strategies of gay and bisexual men in Europe, a survey, disseminated via the gay press and gay associations, was conducted amongst gay and bisexual men in Austria , Switzerland ,


Approaching the HIV epidemic: the community's response.
AIDS Care. 1994;6(5):551-7. Unique Identifier : AIDSLINE MED/95226472
Reid E; HIV and Development Programme, UNDP, New York, NY 10017.
The HIV epidemic comes to people s attention through the language of its texts and its spokespersons. The way it is brought to people s attention will be the critical determinant of how they will respond to it. Currently, the discourse is based on metaphors of epicentres of spread identified as core transmitter groups


Controlled evaluation of a brief intervention for HIV prevention among injecting drug users not in treatment.
AIDS Care. 1994;6(5):559-70. Unique Identifier : AIDSLINE MED/95226473
Baker A; Kochan N; Dixon J; Heather N; Wodak A; National Drug & Alcohol Research Centre, University of New South; Wales, Sydney, Australia.
This study evaluated the effectiveness of a brief intervention (BI), a one-session motivational interview, in reducing HIV risk-taking behaviour among injecting drug users (IDU) not enrolled in any form of treatment for drug dependence. IDU were randomly assigned to either BI or a non-intervention control condition (N


Volunteers in an HIV social care organization.
AIDS Care. 1994;6(5):571-85. Unique Identifier : AIDSLINE MED/95226474
Bebbington AC; Gatter PN; Personal Social Services Research Unit, University of Kent,; Canterbury, UK.
This study describes volunteers who were trained at a large HIV social care centre in South London during its first two years of operation. Many shared similar backgrounds to their clients; indeed some service users were also volunteers. Common motivations for volunteering were to learn more about HIV, to give somethi


Psychosexual problems in people with HIV infection: controlled study of gay men and men with haemophilia.
AIDS Care. 1994;6(5):587-93. Unique Identifier : AIDSLINE MED/95226475
Jones M; Klimes I; Catalan J; Bethlem Royal Hospital, London, UK.
HIV infection can be associated with major psychological and social disturbance. Psychosexual problems would be expected to arise in the context of the infection, in view of the contribution that sexual behaviour can make to the acquisition and spread of HIV infection. Here the results of a study of the psychosexual c


Condom use among criminally-involved adolescents.
AIDS Care. 1994;6(5):595-603. Unique Identifier : AIDSLINE MED/95226476
Magura S; Shapiro JL; Kang SY; National Development and Research Institutes, Inc., New York, NY; 10013.
Condom use was studied for 421 sexually active, minority male adolescents who were currently in jail in New York City. Over three-quarters of the youths were users of alcohol and marijuana and about one-quarter were users of cocaine or crack, but drug injectors were rare. In the six months before arrest they had multi


A review of the HIV-related sexual behaviour of gay men and men who have sex with men.
AIDS Care. 1994;6(5):605-17; discussion 619-24. Unique Identifier : AIDSLINE MED/95226477
Donovan C; Mearns C; McEwan R; Sugden N; Department of Epidemiology and Public Health, Medical School,; University of Newcastle Upon Tyne, UK.
In the last decade studies have identified a myriad of factors associated with continued risky sex in gay men and men who have sex with men. More recently the phenomenon of relapse has been identified among this population. The results of such studies have been fed into the ongoing development of strategies to preve


WHO Global AIDS Statistics.
AIDS Care. 1994;6(5):637-8. Unique Identifier : AIDSLINE MED/95226478
Preparation and characterization of antisense oligonucleotide-peptide hybrids containing viral fusion peptides.
Bioconjug Chem. 1995 Jan-Feb;6(1):43-53. Unique Identifier : AIDSLINE MED/95226489
Soukchareun S; Tregear GW; Haralambidis J; Howard Florey Institute of Experimental Physiology and Medicine,; University of Melbourne, Parkville, Victoria, Australia.
We have developed a strategy for the synthesis of novel oligodeoxynucleotide (ODN)-peptide conjugates on a scale suitable for the investigation of their potential as antisense inhibitors of gene expression. These conjugates have the 3 -terminus of the antisense oligodeoxynucleotide linked covalently to the N-terminus


[Tuberculous splenic abscesses in AIDS (letter)]
Enferm Infecc Microbiol Clin. 1995 Feb;13(2):126. Unique Identifier : AIDSLINE MED/95226509
Lozano F; Gomez Mateos J
[Disseminated herpes zoster with pneumonitis in an HIV-positive patient (letter)]
Enferm Infecc Microbiol Clin. 1995 Feb;13(2):128-9. Unique Identifier : AIDSLINE MED/95226512
Geijo P; Santiago M; Ruiz D; de Benito L
[Visceral leishmaniasis in patients with HIV infection]
Enferm Infecc Microbiol Clin. 1995 Feb;13(2):73-9. Unique Identifier : AIDSLINE MED/95226516
Ribera E; Cucurull E; Ocana I; Vallespi T; Gasser I; Juste C; Unidad de Enfermedades Infecciosas Servicio de Medicina Interna,; Ciudad Sanitaria Vall d'Hebron, Universidad Autonoma, Barcelona.
BACKGROUND: Visceral leishmaniasis (VL) is an endemic parasitosis in Spain with a frequency which is increasing, specially among those patients with HIV infection. METHODS: The clinical characteristics of 36 episodes of VL in 20 patients with HIV infection diagnosed in the authors


Inhibition of human immunodeficiency virus type-1 by retroviral vectors expressing antisense-TAR.
Hum Gene Ther. 1994 Dec;5(12):1467-75. Unique Identifier : AIDSLINE MED/95226526
Chuah MK; Vandendriessche T; Chang HK; Ensoli B; Morgan RA; Clinical Gene Therapy Branch, National Institutes of Health,; Bethesda, MD 20892.
The human immunodeficiency virus type-1 (HIV-1) Tat activation response (TAR) region is essential for Tat-mediated trans-activation of the HIV-1 long terminal repeat (LTR). The TAR element is present on the 5 and 3 ends of all HIV-1 transcripts and is relatively conserved among different HIV-1 isolates. These proper


[The assessment and nutritional support of patients with the acquired immunodeficiency syndrome]
Nutr Hosp. 1995 Jan-Feb;10(1):35-9. Unique Identifier : AIDSLINE MED/95226537
Gil Canalda I; Bacaicoa A; Cos Blanco A; Weisz P; Lopez Guzman A; Mejia A; Gomez Candela C; Servicio de Nutricion y Dietetica, Hospital La Paz, Madrid.
Given the negative effect of malnutrition on the immune function, the possibility must be considered that this also affects the clinical progression of AIDS patients. This study was aimed at assessing the state and nutritional support indicated for patients diagnosed as having AIDS. 114 patients admitted to our hospit


Paromomycin-associated pancreatitis in HIV-related cryptosporidiosis.
Ann Pharmacother. 1995 Jan;29(1):22-4. Unique Identifier : AIDSLINE MED/95226747
Tan WW; Chapnick EK; Abter EI; Haddad S; Zimbalist EH; Lutwick LI; Department of Medicine, Maimonides Medical Center, Brooklyn, NY; 11219.
OBJECTIVE: To report a case of pancreatitis related to paromomycin administration. CASE SUMMARY: A 39-year-old man with AIDS developed pancreatitis concurrent with successful treatment of intestinal cryptosporidiosis with paromomycin. The hyperamylasemia resolved with discontinuation of the agent and recurred when par


Elevation of intracranial pressure in acute AIDS-related cryptococcal meningitis.
Clin Investig. 1994 Dec;72(12):1020-6. Unique Identifier : AIDSLINE MED/95226817
Malessa R; Krams M; Hengge U; Weiller C; Reinhardt V; Volbracht L; Rauhut F; Brockmeyer NH; Neurologische Klinik, Universitatsklinikum Essen, Germany.
Prior to the AIDS-era, elevation of intracranial pressure was known to be a typical complication of cryptococcal meningitis associated with an increased risk of early death. In AIDS-patients, however, the prevalence and clinical significance of this complication are as yet unclear. We analysed clinical features and co


Insulin-dependent diabetes mellitus following pentamidine therapy in a patient with AIDS.
Clin Investig. 1994 Dec;72(12):1027-9. Unique Identifier : AIDSLINE MED/95226818
Liegl U; Bogner JR; Goebel FD; Medizinische Poliklinik, Klinikum Innenstadt, Universitat; Munchen, Germany.
Pentamidine is known to cause severe dysglycaemia by damaging beta-cell function of the pancreas. The exact mechanism still remains unclear. We report the case of a 53-year-old man infected with the human immunodeficiency virus who developed insulin-dependent permanent diabetes mellitus 3 days after starting intraveno


Sustained elimination of hepatitis B virus from serum induced in a patient with chronic hepatitis B and advanced human immunodeficiency virus infection.
Clin Investig. 1994 Dec;72(12):1030-6. Unique Identifier : AIDSLINE MED/95226819
Wolfel T; Schirmacher P; Schlaak J; Knolle P; Dienes HP; Dippold W; Meyer zum Buschenfelde KH; Gerken G; I. Medizinische Klinik und Poliklinik, Johannes; Gutenberg-Universitat, Mainz, Germany.
A 48-year-old male patient was admitted with acquired immunodeficiency syndrome (stage III, Centers for Disease Control 1993) and viremic hepatitis B. Blood CD4 count was 15/microliters. Discontinuation of prednisolone, previously prescribed by the patient s family practitioner because of elevated liver enzymes, resul


Pneumococcal parotitis and cervical lymph node abscesses in an HIV-infected patient.
Clin Investig. 1994 Dec;72(12):1037-40. Unique Identifier : AIDSLINE MED/95226820
Stellbrink HJ; Albrecht H; Greten H; Medizinische Kernklinik und Poliklinik, Universitatskrankenhaus; Eppendorf, Hamburg, Germany.
The case of a 33-year-old patient with rapid onset of bilateral parotid gland and lymph node abscesses is described. The patient was positive for human immunodeficiency virus 1 and presented with a history of interstitial lymphocytic pneumonia and pneumococcal meningitis prior to admission. The patient received cotrim


Treatment of atypical leishmaniasis with interferon gamma resulting in progression of Kaposi's sarcoma in an AIDS patient.
Clin Investig. 1994 Dec;72(12):1041-7. Unique Identifier : AIDSLINE MED/95226821
Albrecht H; Stellbrink HJ; Gross G; Berg B; Helmchen U; Mensing H; Medizinische Kernklinik und Poliklinik, Universitatskrankenhaus; Eppendorf, Hamburg, Germany.
Visceral leishmaniasis (kala-azar) affecting HIV-infected patient is being reported in increasing frequency. A 40-year-old German bisexual patient with full-blown AIDS is described who presented with Kaposi s sarcoma, epigastric pain, diarrhea, and weight loss but without fever. Leishmania amastigotes were initially f


A high prevalence of human T-lymphotropic virus type I carriers in patients with antithyroid antibodies.
Thyroid. 1994 Winter;4(4):415-9. Unique Identifier : AIDSLINE MED/95226914
Mizokami T; Okamura K; Ikenoue H; Sato K; Kuroda T; Maeda Y; Fujishima M; Second Department of Internal Medicine, Faculty of Medicine,; Kyushu University, Fukuoka, Japan.
Human T-lymphotropic virus type I (HTLV-I) is a causative retrovirus of adult T-cell leukemia lymphoma and HTLV-I associated myelopathy/tropical spastic paraparesis. HTLV-I is also associated with some forms of pulmonary alveolitis, chronic arthropathy, polymyositis, and uveitis. In this study, the possible role of HT


Professor banned from transfusion building [news]
BMJ. 1995 Mar 18;310(6981):690. Unique Identifier : AIDSLINE MED/95226948
Connor S
Search for HIV vaccine faces setback [news]
BMJ. 1995 Mar 18;310(6981):691. Unique Identifier : AIDSLINE MED/95226949
Connor S
Kaposi's sarcoma following allogeneic bone marrow transplantation.
Bone Marrow Transplant. 1994 Dec;14(6):999-1001. Unique Identifier : AIDSLINE MED/95227123
Helg C; Adatto M; Salomon D; Roux E; Miralbell R; Chapuis B; Saurat JH; Department of Medicine, University Hospital, Geneva, Switzerland.
Localised Kaposi s sarcoma (KS) was diagnosed 240 days after allogeneic bone marrow transplantation (BMT) in a severely immunosuppressed HIV negative patient with genetic predisposition. The tumour was of host origin, based on PCR amplification of DNA minisatellites. Treatment with radiotherapy prompted almost complet


Cases of interest/regulatory update.
Medsurg Nurs. 1995 Apr;4(2):149-50. Unique Identifier : AIDSLINE MED/95227266
Kolodner DE
The negative pregnancy test. An opportunity for preconception care.
Arch Fam Med. 1995 Apr;4(4):340-5. Unique Identifier : AIDSLINE MED/95227381
Jack BW; Campanile C; McQuade W; Kogan MD; Department of Family Medicine, Brown University School of; Medicine, Providence, RI, USA.
OBJECTIVE: To identify women who would likely benefit from preconception care. METHODS: A comprehensive preconception risk survey was administered during a structured interview to 136 women who had a negative pregnancy test visit in a family practice residency ambulatory practice. The survey solicited the presence of


Hearing people through their pain.
J Trauma Stress. 1995 Jan;8(1):5-28. Unique Identifier : AIDSLINE MED/95227540
Egendorf A
The first goal in this clinical and theoretical essay is to specify what it means to hear people through their pain, by articulating intuitions that are seldom put in formal terms. What and how and whom we hear shift depending on whether we are (1) uncovering the facts, (2) appreciating their meaning with another s li


Local therapy for mucocutaneous Kaposi's sarcoma in patients with acquired immunodeficiency syndrome.
Dermatol Surg. 1995 Mar;21(3):205-8. Unique Identifier : AIDSLINE MED/95227567
Webster GF; Department of Dermatology, Jefferson Medical College,; Philadelphia, Pennsylvania 19107-5102, USA.
BACKGROUND. Kaposi s sarcoma (KS) accounts for significant morbidity in AIDS patients. Lessons are often numerous, disfiguring, painful, and may interfere with function. Although generalized therapy is available, local treatment is often more desirable. OBJECTIVE. To summarize the available data on local therapy for K


Peptidomimetic antagonists designed to inhibit the binding of CD4 to HIV GP120.
Bioorg Med Chem. 1994 Sep;2(9):1007-13. Unique Identifier : AIDSLINE MED/95227602
Ramurthy S; Lee MS; Nakanishi H; Shen R; Kahn M; Department of Pathobiology, University of Washington, Seattle; 98195.
Attempts to enhance the efficacy of our previously reported CD4 CDR2-like (residues 40-45) mimetic 1 by incorporation of the critical guanidine residue Arg-59 of CD4 are described.


Design of orally bioavailable, symmetry-based inhibitors of HIV protease.
Bioorg Med Chem. 1994 Sep;2(9):847-58. Unique Identifier : AIDSLINE MED/95227603
Kempf DJ; Marsh KC; Fino LC; Bryant P; Craig-Kennard A; Sham HL; Zhao C; Vasavanonda S; Kohlbrenner WE; Wideburg NE; et al; Pharmaceutical Products Division, Abbott Laboratories, Abbott; Park, IL 60064.
A series of novel inhibitors of HIV-1 protease with excellent oral bioavailability is described. Differential acylation of the two amino groups of symmetry-based diamine core groups 2-5 led to unsymmetrically substituted inhibitors 17-43, many of which inhibited HIV protease at subnanomolar concentrations. Anti-HIV ac


Synthesis, antiviral activity, and bioavailability studies of gamma-lactam derived HIV protease inhibitors.
Bioorg Med Chem. 1994 Sep;2(9):859-79. Unique Identifier : AIDSLINE MED/95227604
Hungate RW; Chen JL; Starbuck KE; Vacca JP; McDaniel SL; Levin RB; Dorsey BD; Guare JP; Holloway MK; Whitter W; et al; Merck Research Laboratories, West Point, PA 19486.
Incorporation of a gamma-lactam in hydroxyethylene isosteres results in modest inhibitors of HIV-1 protease. Additional structural activity studies have produced significantly more potent inhibitors with the introduction of the trisubstituted cyclopentane (see compound 20) as the optimum substituent for the C-terminus


HIV-1 protease inhibitors: ketomethylene isosteres with unusually high affinity compared with hydroxyethylene isostere analogs.
Bioorg Med Chem. 1994 Sep;2(9):919-25. Unique Identifier : AIDSLINE MED/95227608
Marinier A; Toth MV; Houseman K; Mueller R; Marshall GR; Department of Moelcular Biology and Pharmacology, Washington; University, St. Louis, MO 63130.
HIV protease is a member of the aspartic proteinase family of proteolytic enzymes which include pepsin and renin. In contrast to the enhanced affinity seen with renin and pepsin upon conversion of the transition-state isostere, ketomethylene, to the hydroxyethylene, a set of HIV


The association between HIV phenotype, virus burden, codon 215 mutation and CD4 cell decline [letter; comment]
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):101-2. Unique Identifier : AIDSLINE MED/95227732
Sabin CA; Mocroft AA; Phillips AN
Bioelectrical impedance analysis as a predictor of survival in patients with human immunodeficiency virus infection.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):20-5. Unique Identifier : AIDSLINE MED/95227734
Ott M; Fischer H; Polat H; Helm EB; Frenz M; Caspary WF; Lembcke B; Division of Gastroenterology, University Hospital, Johann; Wolfgang Goethe University, Frankfurt, Germany.
In patients with AIDS, short-term survival has been related to body weight, body composition, and serum nutritional parameters, but their prognostic impact at earlier stages of the HIV infection is not known. With an individual follow-up period of 1,000 days, we investigated the prognostic relevance of electrical tiss


The rocky road to an AIDS vaccine [editorial; comment]
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):26-9. Unique Identifier : AIDSLINE MED/95227735
Osborn JE
Strategies for addressing the social and behavioral challenges of prophylactic HIV vaccine trials [see comments]
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):30-5. Unique Identifier : AIDSLINE MED/95227736
Chesney MA; Lurie P; Coates TJ; Center for AIDS Prevention Studies, School of Medicine,; University of California, San Francisco, USA.
Incentives and disincentives to participate in prophylactic HIV vaccine research [see comments]
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):36-42. Unique Identifier : AIDSLINE MED/95227737
Jenkins RA; Temoshok LR; Virochsiri K; Henry M. Jackson Foundation for the Advancement of Military; Medicine & Military Medical Consortium for Applied Retroviral; Research, Rockville, MD, USA.
An anonymous cross-sectional paper-and-pencil survey was used to assess incentives and disincentives to participate in a Phase I preventive human immunodeficiency virus (HIV) vaccine trial in a potential Thai target population. A total of 255 persons employed in health care service and research settings completed ques


Predictors of HIV disease progression in women.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):43-50. Unique Identifier : AIDSLINE MED/95227738
Clark RA; Blakley SA; Rice J; Brandon W; Louisiana State University Medical Center, New Orleans, USA.
A retrospective cohort study was conducted to analyze variables predictive of acquired immunodeficiency syndrome (AIDS), as defined by the Centers for Disease Control (CDC) in 1987, and death in 224 women infected with the human immunodeficiency virus (HIV) who were evaluated through two HIV outpatient programs in New


Transient high titers of HIV-1 in plasma and progression of disease.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):51-7. Unique Identifier : AIDSLINE MED/95227739
Fiscus SA; Heggem-Snow A; Troiani L; Wallmark E; Folds JD; Sheff B; van der Horst CM; Department of Microbiology and Immunology, University of North; Carolina at Chapel Hill 27599, USA.
Periodic quantitative HIV-1 plasma cultures were performed on 28 seropositive individuals who had CD4 cells


Active human herpesvirus (HHV-6) infection of the central nervous system in patients with AIDS.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):69-73. Unique Identifier : AIDSLINE MED/95227741
Knox KK; Carrigan DR; Department of Pathology, Medical College of Wisconsin, Milwaukee; 53226, USA.
White matter disease is a relatively common neuropathological change observed in the central nervous system (CNS) tissues of patients with AIDS at autopsy. This disease ranges from small foci of myelin loss to extensive areas of demyelination. In the studies reported here, four of six unselected adult patients with AI


Recent trends in Pneumocystis carinii pneumonia as AIDS-defining disease in nine European countries. Coordinators for AIDS Surveillance.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):74-80. Unique Identifier : AIDSLINE MED/95227742
Delmas MC; Schwoebel V; Heisterkamp SH; Downs AM; Ancelle-Park RA; Brunet JB; European Centre for the Epidemiological Monitoring of AIDS,; Saint-Maurice, France.
We analyzed the proportion of AIDS cases with Pneumocystis carinii pneumonia (PCP) at diagnosis among the 43,198 adult AIDS cases diagnosed since January 1988 and reported by June 1992 in Austria , Belgium , Fran


Risk factors for HTLV-I among heterosexual STD clinic attenders.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):81-8. Unique Identifier : AIDSLINE MED/95227743
Figueroa JP; Morris J; Brathwaite A; Ward E; Peruga A; Hayes R; Vermund SH; Blattner W; Ministry of Health, Kingston, Jamaica.
Human T-cell lymphotropic virus type 1 (HTLV-I) status was assessed in 994 patients attending a sexually transmitted disease (STD) clinic in Kingston, Jamaica , between November 1990 and January 1991 for a new STD complaint. Of 515 heterosexual men, 36 (7.0%) were HTLV-I seropositi


Incidence and risk factors for human T-lymphotropic virus type II seroconversion among injecting drug users in Baltimore, Maryland, U.S.A.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):89-96. Unique Identifier : AIDSLINE MED/95227744
Vlahov D; Khabbaz RF; Cohn S; Galai N; Taylor E; Kaplan JE; Department of Epidemiology, Johns Hopkins School of Hygiene and; Public Health, Baltimore, Maryland.
To determine the incidence of and risk factors for human T-lymphotropic virus, type II (HTLV-II) seroconversion among injecting drug users (IDUs), specimens from IDUs recruited into the ALIVE Study in 1988/1989 were assayed at baseline for antibody to HTLV with use of enzyme immunoassay and Western blot. Participants


Lack of short-term efficacy of N-acetyl-L-cysteine in human immunodeficiency virus-positive patients with CD4 cell counts < 250/mm3 [letter]
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):98-9. Unique Identifier : AIDSLINE MED/95227746
Clotet B; Gomez M; Ruiz L; Sirera G; Romeu J
Diabetes insipidus and AIDS [letter]
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):99. Unique Identifier : AIDSLINE MED/95227747
Harris PJ; Curry R
Reliability of sexual risk behavior interviews on an alcohol rehabilitation unit.
Psychiatr Serv. 1995 Feb;46(2):115-7. Unique Identifier : AIDSLINE MED/95227772
Mahler J; Hull J; Stebinger A; Perry S; Frances R; Cornell University Medical College, New York City, USA.
HIV-related cases among 2,094 admissions to a psychiatric hospital.
Psychiatr Serv. 1995 Feb;46(2):131-5. Unique Identifier : AIDSLINE MED/95227775
Sacks M; Burton W; Dermatis H; Looser-Ott S; Perry S; Department of Psychiatry, Payne-Whitney Clinic, New York; Hospital-Cornell Medical Center, New York, USA.
OBJECTIVE: Admissions to an acute care psychiatric hospital were studied to determine what proportion of admissions were for HIV-related psychiatric disturbances, what evidence exists that the HIV-related admissions constitute a new population of psychiatric inpatients, and whether any psychiatric variables distinguis


Rates of sexually transmitted diseases among patients in a psychiatric emergency service [published erratum appears in Psychiatr Serv 1995 Apr;46(4):358]
Psychiatr Serv. 1995 Feb;46(2):136-40. Unique Identifier : AIDSLINE MED/95227776
Sitzman BT; Burch EA Jr; Bartlett LS; Urrutia G; University of Virginia Health Sciences Center, Charlottesville; 22908, USA.
OBJECTIVE: This study sought to estimate the prevalence of non-HIV sexually transmitted diseases among patients admitted to a psychiatric emergency service and to identify characteristics that might place members of this population at increased risk of acquiring these diseases. METHODS: Hospital medical records and re


An improved system for packaging recombinant adeno-associated virus vectors capable of in vivo transduction.
Gene Ther. 1995 Jan;2(1):29-37. Unique Identifier : AIDSLINE MED/95227863
Flotte TR; Barraza-Ortiz X; Solow R; Afione SA; Carter BJ; Guggino WB; Eudowood Division of Pediatric Respiratory Sciences, Johns; Hopkins University School of Medicine, Baltimore, MD 21287-2533.
Adeno-associated virus (AAV) vectors are potentially useful for gene therapy of a number of human diseases. However, the use of these vectors has been limited by the lack of stable vector-packaging cell lines. The difficulties in developing packaging cell lines relate to low levels of rep gene expression from the AAV-


Anonymous HIV survey results [news]
Midwives. 1995 Mar;108(1286):94. Unique Identifier : AIDSLINE MED/95227916
Acquired immunodeficiency syndrome with CNS toxoplasmosis: a case report.
Chung Hua I Hsueh Tsa Chih (Taipei). 1995 Jan;55(1):69-73. Unique Identifier : AIDSLINE MED/95227964
Chang CC; Liao ST; Kuo SY; Chu SJ; Chen CM; Shih TY; Chang ML; Chang DM; Department of Internal Medicine, Taipei Municipal Jen-Ai; Hospital, Taiwan, R.O.C.
Central nervous system (CNS) toxoplasmosis is an important infectious complication of acquired immunodeficiency syndrome (AIDS) which appears to result from reactivation of a previously acquired infection and requires prolonged treatment. A 31-year-old male presented in a drowsy mental state and with an unstable gait.


HIV-infected physicians: how best to protect the public?
Can Med Assoc J. 1995 Apr 1;152(7):1059-62. Unique Identifier : AIDSLINE MED/95227983
Karrel AI; AIDS Committee of Toronto, ON.
The debate about public safety as it relates to physicians living with HIV infection concerns all Canadians. A review of the evidence strongly suggests that the best way to protect the public is by strict adherence to universal precautions and the voluntary use of expert advisory panels on an anonymous basis. Mandator


Reported use of strategies by surgeons to prevent transmission of bloodborne diseases [see comments]
Can Med Assoc J. 1995 Apr 1;152(7):1089-95. Unique Identifier : AIDSLINE MED/95227987
Wright JG; Young NL; Stephens D; Division of Orthopaedic Surgery, Hospital for Sick Children,; University of Toronto, Ont.
OBJECTIVE: To determine how often surgeons use strategies to prevent the transmission of bloodborne diseases and what factors are associated with the use of these strategies. DESIGN: Cross-sectional mail survey. SETTING: Secondary and tertiary care teaching hospitals affiliated with the University of Toronto. PARTICIP


Canada's AIDS toll mounts. [news]
Can Med Assoc J. 1995 Apr 1;152(7):1099. Unique Identifier : AIDSLINE MED/95227988
Salicylic acid inhibits ultraviolet- and cis-platinum-induced human immunodeficiency virus expression.
Cancer Res. 1995 Apr 15;55(8):1696-700. Unique Identifier : AIDSLINE MED/95228054
Woloschak GE; Panozzo J; Schreck S; Libertin CR; Center for Mechanistic Biology and Biotechnology, Argonne; National Laboratory, Illinois 60439-4833, USA.
Previous studies have shown that exposure of HeLa cells stably transfected with an HIV-long terminal repeat-chloramphenicol acetyltransferase (HIV-LTR-CAT) construct to many DNA-damaging agents (such as UV light) induces expression from the HIV LTR. By culturing the cells with salicylic acid we demonstrated dose-depen


Pathology of AIDS-related liver disease.
Dig Dis. 1994 Nov-Dec;12(6):321-30. Unique Identifier : AIDSLINE MED/95228199
Lefkowitch JH; Department of Pathology, College of Physicians and Surgeons,; Columbia University, New York, NY 10032.
Hepatomegaly and abnormalities of serum liver tests are common problems in patients with acquired immune deficiency syndrome. Opportunist infections (Mycobacterium avium-intracellulare and cytomegalovirus ) and neoplasms (lymphoma, Kaposi s sarcoma) are among the most prevalent hepa


Treatment of skin diseases in HIV-infected patients.
Dermatol Clin. 1995 Jan;13(1):231-8. Unique Identifier : AIDSLINE MED/95228230
Buchness MR; Department of Medicine, St. Vincent's Hospital, New York, New; York, USA.
Skin diseases are common in HIV-infected patients. Although some of the cutaneous manifestations of HIV-infection resemble more severe forms of common skin diseases, as with seborrheic dermatitis and psoriasis, the response to standard treatment is not as expected. Indeed, this may be the clue that leads the clinician


Foscarnet and ganciclovir pharmacokinetics during concomitant or alternating maintenance therapy for AIDS-related cytomegalovirus retinitis.
Clin Pharmacol Ther. 1995 Apr;57(4):403-12. Unique Identifier : AIDSLINE MED/95228252
Aweeka FT; Gambertoglio JG; Kramer F; van der Horst C; Polsky B; Jayewardene A; Lizak P; Emrick L; Tong W; Jacobson MA; Division of Clinical Pharmacy, University of California, San; Francisco 94143-0622, USA.
INTRODUCTION: The use of foscarnet and ganciclovir as a combination treatment for cytomegalovirus retinitis is increasing because of limitations associated with single agent therapy. METHODS: The pharmacokinetics of foscarnet and ganciclovir were determined in 13 patients receiving


[Immunologic study on pregnancy induced hypertension]
Chung Hua Fu Chan Ko Tsa Chih. 1994 Nov;29(11):684-6. Unique Identifier : AIDSLINE MED/95228487
Guan Z; Wong XY
[The abnormalities of the cellular immunity in rheumatoid synovium]
Chung Hua Nei Ko Tsa Chih. 1994 Sep;33(9):601-4. Unique Identifier : AIDSLINE MED/95228524
Xue CS; Dong Y; Yu MX; Department of Medicine, Peking Union Medical College Hospital,; Beijing.
With the technique of immunohistochemical (ABC) method monoclonal antibodies were used to identify the lymphocyte subsets, macrophage and the expression of class II MHC (HLA-DR, HLA-DQ) antigens in the synovium cells from 18 RA patients and 8 patients with osteoarthritis as control. The results showed that the main ce


Surveillance of acquired immunodeficiency syndrome in Africa. An analysis of evaluations of the World Health Organization and other clinical definitions.
Epidemiol Rev. 1994;16(2):403-17. Unique Identifier : AIDSLINE MED/95228804
Belec L; Brogan T; Keou FX; Georges AJ; Department of Microbiology (Virology), Broussais University; Hospital, Paris, France.
Trends and patterns in the transmission of bloodborne pathogens to health care workers.
Epidemiol Rev. 1994;16(2):437-50. Unique Identifier : AIDSLINE MED/95228806
Lanphear BP; Department of Pediatrics, University of Rochester, School of; Medicine and Dentistry, NY, USA.
The key determinants of transmission of bloodborne pathogens are the dose and serum viral concentration of an exposure. This conclusion is supported by data showing that the rate of transmission of hepatitis B virus is elevated if the source patient s viral serum concentration is high and by a comparison of serum conc


Tuberculosis: distribution, risk factors, mortality.
Immunobiology. 1994 Oct;191(4-5):325-36. Unique Identifier : AIDSLINE MED/95229195
Kochi A; Tuberculosis Programme, World Health Organization, Geneva,; Switzerland.
About a century after Koch s discovery of the TB bacilli the tuberculosis epidemic which had appeared to be under control was again recognized as a major global health threat. The decline in the epidemic in this century had been largely through the improved living standards and, eventually, the availability and use of


Epidemiology of tuberculosis: the impact of HIV and multidrug-resistant strains.
Immunobiology. 1994 Oct;191(4-5):337-43. Unique Identifier : AIDSLINE MED/95229196
Crawford JT; National Center for Infectious Diseases, Centers for Disease; Control and Prevention, Atlanta, Georgia.
The recent reemergence of tuberculosis in the United States and other developed countries has been attributed to a number of factors including a decreased emphasis on tuberculosis control and immigration. Perhaps the most significant factor is the association of tuberculosis and HIV/AI


Complicated tuberculosis and residual disease.
Immunobiology. 1994 Oct;191(4-5):344-50. Unique Identifier : AIDSLINE MED/95229197
Trautmann M; Ruhnke M; Held T; Weinke T; Department of Bacteriology, University of Ulm, Germany.
Complicated and extrapulmonary manifestations of tuberculosis (TB) may cause prolonged suffering for the individual patient and represent a high economic burden for the society concerned. Complications of pulmonary TB may be the consequence of reduced individual resistance, immunosuppression or specific immune defects


Immunohistochemical analysis of cell composition and in situ cytokine expression in HIV- and non-HIV-associated tuberculous lymphadenitis.
Immunobiology. 1994 Oct;191(4-5):354-68. Unique Identifier : AIDSLINE MED/95229199
Muller H; Kruger S; Department of Pathology, Medical University of Lubeck, Germany.
Inflammatory cells in lymph nodes of eighteen patients suffering from culture-proven tuberculous lymphadenitis were examined by histological and immunohistochemical techniques. Ten patients suffered from symptomatic HIV-infection and eight patients were immunocompetent individuals without HIV-1 serology. Characteristi


Cytokine patterns at the site of mycobacterial infection.
Immunobiology. 1994 Oct;191(4-5):378-87. Unique Identifier : AIDSLINE MED/95229201
Sieling PA; Modlin RL; Division of Dermatology, UCLA, School of Medicine.
Distinct patterns of T cell cytokine production have been shown to influence the outcome of infection in mouse models and humans. Th1 or Type 1 cytokines, interleukin-2 ( IL-2 ) and interferon-gamma (IFN-gamma) are generally associated with resistance to infection, where


Macrophage activation and innate resistance to infection in SCID mice.
Immunobiology. 1994 Oct;191(4-5):424-31. Unique Identifier : AIDSLINE MED/95229206
Bancroft GJ; Kelly JP; Department of Clinical Sciences, London School of Hygiene and; Tropical Medicine, England.
Resistance to infection against a variety of pathogens requires the co-ordinated interaction of both the innate and acquired immune responses. Mice bearing the SCID mutation are devoid of T and B cells but retain elements of the innate immune system including natural killer (NK) cells, macrophages, granulocytes and co


Adhesion molecules mediating recruitment of monocytes to inflamed tissue.
Immunobiology. 1994 Oct;191(4-5):474-7. Unique Identifier : AIDSLINE MED/95229211
Patarroyo M; Microbiology and Tumorbiology Center, Karolinska Institute,; Stockholm, Sweden.
Three families of cell-surface proteins are largely responsible for the adherence of leukocytes to cells and matrices: integrins, immunoglobulin (Ig)-related molecules and selectins. Blood monocytes express beta 1 integrins VLA-4, -5 and -6 and beta 2 integrins CD11a/CD18, CD11b/CD18 and CD11c/CD18. These cells also e


Protective and memory immunity in mice infected with Mycobacterium tuberculosis.
Immunobiology. 1994 Oct;191(4-5):503-8. Unique Identifier : AIDSLINE MED/95229214
Orme I; Department of Microbiology, Colorado State University, Fort; Collins.
Experimental approaches to mechanisms of protection and pathogenesis in M. tuberculosis infection.
Immunobiology. 1994 Oct;191(4-5):526-36. Unique Identifier : AIDSLINE MED/95229217
Bloom BR; Flynn J; McDonough K; Kress Y; Chan J; Howard Hughes Medical Institute, Albert Einstein College of; Medicine, Bronx, New York.
It has, for many years, been widely assumed that the fundamental mechanism of protection in tuberculosis infection is a CD4 T cell response producing lymphokines that activate macrophages to kill or restrict the intracellular growth of M. tuberculosis. Just as certain cytokines, e.g. IFN-gamma, are currently perceived


Immunotherapy of tuberculosis with Mycobacterium vaccae NCTC 11659.
Immunobiology. 1994 Oct;191(4-5):555-63. Unique Identifier : AIDSLINE MED/95229220
Stanford JL; Stanford CA; Department of Medical Microbiology, University College London; Medical School, England.
The history of immunotherapy for tuberculosis is briefly reviewed, and the early appreciation of the importance of secreted antigens, common mycobacterial antigens and stress proteins is noted. The methods by which Mycobacterium vaccae strain NCTC 11659 was selected for special attention, and results of some of the pi


Cytokine regulation of disease progression in leprosy and tuberculosis.
Immunobiology. 1994 Oct;191(4-5):564-8. Unique Identifier : AIDSLINE MED/95229221
Kaplan G; Laboratory of Cellular Physiology and Immunology, Rockefeller; University, New York.
Studies in our laboratory have focussed on the role of cytokines in the regulation of the cellular immune response and disease progression in two important mycobacterial infection of man, namely leprosy and tuberculosis. Our studies in leprosy have involved the use of key regulatory cytokines such as IFN-gamma in the


Use of liposome preparation to treat mycobacterial infections.
Immunobiology. 1994 Oct;191(4-5):578-83. Unique Identifier : AIDSLINE MED/95229223
Bermudez LE; Kuzell Institute for Arthritis and Infectious Diseases, Medical; Research Institute of San Francisco, Pacific Presbyterian Medical; Center, CA.
Infections caused by organisms of the genus mycobacteria, such as tuberculosis M. avium disseminated infection in AIDS patients and leprosy, are extremely common around the world. Mycobacteria are intracellular organisms that invade and multiply chiefly within phagocytic cells. Antibiotic resistance among mycobacteria


Testing blood donors for HIV: current controversies.
Immunol Invest. 1995 Jan-Feb;24(1-2):147-54. Unique Identifier : AIDSLINE MED/95229228
Busch MP; Department of Laboratory Medicine, University of California, San; Francisco, USA.
Despite an estimated risk of HIV infection from anti-HIV screened blood transfusions of less than one in 225,000 per unit, there continues to be strong pressure to implement additional donor screening and viral inactivation procedures. Decisions to implement such procedures must be based on analyses that incorporate a


Viral contamination of blood components and approaches for reduction of infectivity.
Immunol Invest. 1995 Jan-Feb;24(1-2):25-48. Unique Identifier : AIDSLINE MED/95229237
Dodd RY; American Red Cross, Rockville MD 20855, USA.
Currently, the United States blood supply offers a relatively low risk of viral infection. This is a result of careful selection of donors and extensive laboratory testing using sensitive procedures. Epidemiologic data show that there is some room for improvement in donor selection, bu


Novel cellular therapies.
Immunol Invest. 1995 Jan-Feb;24(1-2):411-20. Unique Identifier : AIDSLINE MED/95229250
Klein HG; Department of Transfusion Medicine, Warren G. Magnuson Clinical; Center, National Institutes of Health, USA.
Uses of intravenous gammaglobulin in immune hematologic disease.
Immunol Invest. 1995 Jan-Feb;24(1-2):451-6. Unique Identifier : AIDSLINE MED/95229255
Bussel JB; Szatrowski TP; New York Hospital-Cornell University Medical Center, NY 10021,; USA.
In summary, for intravenous gammaglobulin use of ITP in children and adults, it is clear that intravenous gammaglobulin is an effective way to increase the platelet count acutely and this will be faster than or as fast as any other therapy. However, there is no proven curative effect of IV gammaglobulin. Its use in si


Effects of naloxone opiate blockade on the immunomodulation induced by exercise in rats.
Int J Sports Med. 1995 Jan;16(1):29-33. Unique Identifier : AIDSLINE MED/95229277
Bouix O; elMezouini M; Orsetti A; Department of Physiology, Faculty of Medicine, Montpellier,; France.
The purpose of this study was to examine the possible involvement of the endogenous opiate system in the changes in immune competence induced by isolated exercise. Male untrained rats were subjected to a 2.5 hours swimming exercise bout. Animals were killed 15 min after the end of the exercise. The concentration of le


Seven resolutions to combat AIDS [news]
Int Nurs Rev. 1995 Jan-Feb;42(1):10. Unique Identifier : AIDSLINE MED/95229335
HIV/AIDS risk high for nurses/midwives [news]
Int Nurs Rev. 1995 Jan-Feb;42(1):5. Unique Identifier : AIDSLINE MED/95229340
Bacillary angiomatosis: a treatable cause of acute psychiatric symptoms in human immunodeficiency virus infection.
J Clin Psychiatry. 1995 Apr;56(4):161-6. Unique Identifier : AIDSLINE MED/95229563
Baker J; Ruiz-Rodriguez R; Whitfeld M; Heon V; Berger TG; Department of Psychiatry, San Francisco General Hospital, CA; 94110, USA.
BACKGROUND: Bacillary angiomatosis is a systemic infection that has been most commonly reported in the setting of immunosuppression, especially human immunodeficiency virus (HIV) disease. METHOD: We report two patients who had bacillary angiomatosis who presented with psychia


Dimerization of HIV-1Lai RNA at low ionic strength. An autocomplementary sequence in the 5' leader region is evidenced by an antisense oligonucleotide.
J Biol Chem. 1995 Apr 7;270(14):8209-16. Unique Identifier : AIDSLINE MED/95229640
Muriaux D; Girard PM; Bonnet-Mathoniere B; Paoletti J; Unite de Biochimie-Enzymologie, URA 147 CNRS, Institut Gustave; Roussy, Villejuif, France.
Genomic human immunodeficiency virus type 1 (HIV-1) RNA consists of two identical RNA molecules joined noncovalently near their 5 ends in a region called the dimer linkage structure (DLS). Previous work has shown that the putative DLS is localized in a 113-nucleotide domain encompassing the 5 end of the gag gene. Th


A recombinant human immunodeficiency virus type-1 capsid protein (rp24): its expression, purification and physico-chemical characterization.
J Virol Methods. 1994 Dec;50(1-3):1-9. Unique Identifier : AIDSLINE MED/95229748
Hausdorf G; Gewiess A; Wray V; Porstmann T; Institut fur Biochemie der Charite Humboldt-Universitat,; Medizinische Fakultat (Charite), Med. Universit atsklinik III,; Berlin, Germany.
An expression system has been established in Escherichia coli to facilitate the preparation of the HIV-1 capsid protein in amounts sufficient for structural analysis. A plasmid vector pTCA5, containing the gene for the recombinant HIV-1 capsid protein rp24 under the control of the lambda-PR-promoter, was constructed w


Accurate and differential quantitation of HIV-1 tat, rev and nef mRNAs by competitive PCR.
J Virol Methods. 1994 Dec;50(1-3):115-28. Unique Identifier : AIDSLINE MED/95229751
Merzouki A; Mo T; Vellani N; Pattullo A; Estable M; O'Shaughnessy M; Tsoukas C; Cassol S; B.C. Centre for Excellence in HIV/AIDS, Saint Paul's Hospital,; Vancouver, British Columbia, Canada.
An accurate method is described for measuring the relative abundance of HIV-1 regulatory mRNAs directly in clinical specimens. Specimen RNA is reverse transcribed and coamplified with a common competitor containing tat, rev and nef internal standards using fluorescent primers and a competitive polymerase chain reactio


Detection of human T-cell leukaemia virus 1 permissive cells using cell lines producing selectable recombinant virions.
J Virol Methods. 1994 Dec;50(1-3):219-25. Unique Identifier : AIDSLINE MED/95229762
Copeland KF; Haaksma AG; Derse D; Heeney JL; Laboratory of Viral Pathogenesis, TNO-Rijswijk, The Netherlands.
A selectable retrovirus vector based on a full length HTLV-1 provirus clone, pCS-HTLV-1, was constructed by replacing the coding regions for tax, rex and the 3 region of env with the prokaryotic neomycin resistance gene under the control of the CMV promoter. Th


SIV- and HIV-2-neutralising antibodies in infected macaques measured by a novel and simple neutralisation test based on a non-commercial antigen-ELISA.
J Virol Methods. 1994 Dec;50(1-3):257-68. Unique Identifier : AIDSLINE MED/95229766
Makoschey B; Faisst AC; Le Grand R; Coulibaly C; Stahl-Hennig C; Hunsmann G; Department of Virology and Immunology, German Primate Centre,; Gottingen.
A method for the measurement of neutralising antibodies (nab) directed against SIVmac or HIV-2 was developed. The assay is based on antigen detection using a non-commercial enzyme-linked immunosorbent assay (ELISA). Studies were carried out to determine the influence of the test conditions on the nab titre. The sensit


Murine retroviral vector that induces long-term expression of HIV-1 envelope protein.
J Virol Methods. 1994 Dec;50(1-3):293-311. Unique Identifier : AIDSLINE MED/95229770
Fujita K; Maldarelli F; Purcell DF; Silver J; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892.
A retroviral vector was constructed that induces long-term expression of human immunodeficiency virus type 1 (HIV-1) rev, vpu and env genes. The vector contains the neo gene and a cytomegalovirus ( CMV ) immediate early promote


Polymerase chain reaction detection of type D simian retrovirus proviral DNA from infected macaques.
J Virol Methods. 1994 Dec;50(1-3):75-86. Unique Identifier : AIDSLINE GENBANK/X05665
Pilcher KY; Avery N; Shiigi SM; Pangares N; Malley A; Axthelm MK; Machida CA; Division of Neuroscience, Oregon Regional Primate Research; Center, Beaverton 97006.
A simple polymerase chain reaction (PCR) approach was developed for detection of Type D simian retrovirus (SRV) serogroup 2 proviral DNA using peripheral blood lymphocytes (PBLs) obtained from infected macaques. PCR primer pairs were developed against serogroup 2 envelope (env) gene sequence, and fidelity of PCR fragm


Human cord blood mononuclear cells are preferentially infected by non-syncytium-inducing, macrophage-tropic human immunodeficiency virus type 1 isolates.
J Clin Microbiol. 1995 Feb;33(2):292-7. Unique Identifier : AIDSLINE MED/95229912
Reinhardt PP; Reinhardt B; Lathey JL; Spector SA; Department of Pediatrics, University of California, San Diego, La; Jolla 92093-0672.
Identification of the factors which impact on the transmission of human immunodeficiency virus type 1 (HIV-1) from an infected mother to her infant is essential for the development of effective strategies to prevent perinatal HIV-1 infection. The current study was designed to determine if unstimulated human neonatal c


Measurement of human immunodeficiency virus type 1 p24 in serum by an ultrasensitive enzyme immunoassay, the two-site immune complex transfer enzyme immunoassay.
J Clin Microbiol. 1995 Feb;33(2):298-303. Unique Identifier : AIDSLINE MED/95229913
Hashida S; Hashinaka K; Nishikata I; Oka S; Shimada K; Saitoh A; Takamizawa A; Shinagawa H; Ishikawa E; Department of Biochemistry, Medical College of Miyazaki, Japan.
Human immunodeficiency virus type 1 (HIV-1) p24 antigen was measured by an ultrasensitive enzyme immunoassay (two-site immune complex transfer enzyme immunoassay). The antigen was reacted simultaneously with 2,4-dinitrophenyl-biotinyl-bovine serum albumin-anti-recombinant p24 (rp24) Fab conjugate and anti-rp24 Fab -b


Specific, sensitive, and rapid assay for human immunodeficiency virus type 1 pol mutations associated with resistance to zidovudine and didanosine.
J Clin Microbiol. 1995 Feb;33(2):342-7. Unique Identifier : AIDSLINE MED/95229922
Frenkel LM; Wagner LE 2nd; Atwood SM; Cummins TJ; Dewhurst S; Department of Pediatrics, University of Rochester, New York.
The effectiveness of antiretroviral therapy may be limited by the development of human immunodeficiency virus type 1 (HIV-1) resistance. Monitoring for resistance will perhaps allow changes in therapy prior to deterioration in the patient s clinical or immunologic status. Our objective was to develop a rapid, specific


In vitro growth of the microsporidian Septata intestinalis from an AIDS patient with disseminated illness.
J Clin Microbiol. 1995 Feb;33(2):463-70. Unique Identifier : AIDSLINE MED/95229944
Doultree JC; Maerz AL; Ryan NJ; Baird RW; Wright E; Crowe SM; Marshall JA; Victorian Infectious Diseases Reference Laboratory, Fairfield; Hospital, Australia.
A new species of microsporidian, Septata intestinalis, was recently recognized as an opportunistic pathogen of AIDS patients. In this study, it was cultured from the nasopharyngeal aspirate of a human immunodeficiency virus type 1-infected patient with disseminated microsp


Serologic evaluation of human immunodeficiency virus type 1-infected individuals from Argentina and the United States indicates a similar distribution of subgroup B isolates.
J Clin Microbiol. 1995 Feb;33(2):481-3. Unique Identifier : AIDSLINE MED/95229948
Warren RQ; Wong MT; Melcher GP; Blatt SP; Cahn P; Perez H; Zapiola I; Bouzas MB; Muchinik G; Anderson SA; et al; Department of Virology and Immunology, Southwest Foundation for; Biomedical Research, San Antonio, Texas 78228.
Utilizing peptides based on the V3 region of gp120, we undertook a serologic examination of human immunodeficiency virus type 1 (HIV-1)-infected individuals from Argentina to determine if prevalent HIV-1 isolates could be identified in this population. Our findings suggest that


Selective binding of peripheral blood lymphocytes to the walls of cerebral vessels in frozen sections of human brain.
J Immunol Methods. 1995 Mar 27;180(2):165-80. Unique Identifier : AIDSLINE MED/95230079
Vora AJ; Perry ME; Hobbs C; Dumonde DC; Brown KA; Division of Immunology, United Medical School, London, UK.
In order to identify the factors that control the binding of blood leucocytes to cerebral blood vessels we have modified and applied the frozen section assay of Stamper and Woodruff to the study of human brain. Cryostat sections of brain tissue obtained at post mortem were overlaid with blood lymphocytes and experimen


HIV infection amongst leprosy patients in south India.
Indian J Lepr. 1994 Oct-Dec;66(4):429-33. Unique Identifier : AIDSLINE MED/95230100
Jayasheela M; Sharma RN; Sekar B; Thyagarajan SP; BCG Laboratories, Guindy, Madras.
In a pilot study, 463 leprosy patients (374 males and 89 females) were investigated for HIV-1 and HIV-2 antibodies by screening tests. Sera positive by the screening tests were subjected to confirmatory tests. Three cases were confirmed to be positive for HIV, two for HIV-1 and one for HIV-2. All the three positive ca


A rapid and sensitive method of identification of HTLV-II subtypes.
J Med Virol. 1995 Jan;45(1):1-9. Unique Identifier : AIDSLINE MED/95230241
Dube S; Spicer T; Bryz-Gornia V; Jones B; Dean T; Love J; Ferrer J; Esteban N; Harrington W Jr; Glaser J; et al; Department of Medicine and Microbiology/Immunology, SUNY Health; Science Center, Syracuse 13210, USA.
There are 2 subtypes of human T-cell lymphoma/leukemia virus type II (HTLV-II), A and B. HTLV-II is increasingly associated with rare forms of lymphocytic neoplasia and a neurodegenerative disorder, characterized by hyperspasticity and ataxia. We have used PCR to amplify, clone and sequence 140 bp of the pol gene from


GACPAT HIV 1 + 2: a simple, inexpensive assay to screen for, and discriminate between, anti-HIV 1 and anti-HIV 2.
J Med Virol. 1995 Jan;45(1):10-6. Unique Identifier : AIDSLINE MED/95230242
Parry JV; Connell JA; Reinbott P; Garcia AB; Avillez F; Mortimer PP; Hepatitis and Retrovirus Laboratory, Central Public Health; Laboratory, London, United Kingdom.
A simple and cheap assay suitable for screening for anti-HIV 1 and anti-HIV 2 and discriminating between them was evaluated. In it specimens are incubated in U-bottomed microplate wells coated with anti-human IgG for 30 min at room temperature. After washing, 100 microliters of a 1 in 50 dilution of HIV 1-coated gelat


Controlled study of human herpesvirus 6 detection in acquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma. The French Study Group for HIV-Associated Tumors.
J Med Virol. 1995 Jan;45(1):106-12. Unique Identifier : AIDSLINE MED/95230243
Fillet AM; Raphael M; Visse B; Audouin J; Poirel L; Agut H; Bacteriology-Virology Laboratory CNRS EP 57, Pitie-Salpetriere; Hospital, France.
Human herpesvirus 6 (HHV-6) is a recently identified lymphotropic herpesvirus, which has been isolated from patients with acquired immunodeficiency syndrome (AIDS) or lymphoproliferative diseases. Two variants A and B of HHV-6 have been described, variant B being more common in children with exanthema subitum. HHV-6 i


Detection of seminal antibodies to human immunodeficiency virus in vaginal secretions after sexual intercourse: possible means of preventing the risk of human immunodeficiency virus transmission in a rape victim.
J Med Virol. 1995 Jan;45(1):113-6. Unique Identifier : AIDSLINE MED/95230244
Belec L; Matta M; Payan C; Tevi-Benissan C; Meillet D; Pillot J; Unite d'Immunologie Microbienne, Institut Pasteur, Paris,; France.
Detection of semen anti-human immunodeficiency virus (HIV) antibodies within the cervicovaginal secretions from a non-HIV-infected woman who has had a recent sexual intercourse with an HIV-infected man is theoretically possible since the seminal fluid from all HIV-infected men contains a high titer of IgG antibodies t


Unbiased usage of T-cell receptor beta variable region genes in peripheral blood cells of hepatitis C patients: no correlation with superantigen effect.
J Med Virol. 1995 Jan;45(1):24-8. Unique Identifier : AIDSLINE MED/95230247
Wang CC; Hwang LH; Yang PM; Chiang BL; Chen PJ; Chen DS; Hepatitis Research Center, National Taiwan University, Taipei,; Republic of China.
Hepatitis C virus (HCV) infection frequently causes chronic hepatitis and lack of virus clearance in these patients. In addition, many patients infected by HCV also present with hypergammaglobulinemia in the early stage of chronic infection. These observations raise a possible viral superantigen effect induced by HCV,


Enteric prevalence of adenovirus in human immunodeficiency virus seropositive patients.
J Med Virol. 1995 Jan;45(1):56-60. Unique Identifier : AIDSLINE MED/95230253
Durepaire N; Ranger-Rogez S; Gandji JA; Weinbreck P; Rogez JP; Denis F; Departement de Virologie, CHU Dupuytren, Limoges, France.
To evaluate the prevalence of adenovirus strains in human immunodeficiency virus (HIV)-positive patients and to investigate their possible role in the onset of diarrhea, a total of 103 stools from HIV-seropositive patients at various stages of infection and 200 stools from sex and age cross-matched control subjects we


Infectious virus titer, replicative and syncytium-inducing capacity of human immunodeficiency virus type 1.
J Med Virol. 1995 Jan;45(1):78-81. Unique Identifier : AIDSLINE MED/95230257
Nkengasong JN; Peeters M; Nys P; Willems B; Piot P; van der Groen G; Department of Infection and Immunity, Institute of Tropical; Medicine, Antwerp, Belgium.
The relationship was investigated between a viral infectious titer in peripheral blood mononuclear cells (PBMC) and plasma on the replicative and syncytium-inducing capacity of human immunodeficiency virus type 1 (HIV-1) isolates. The replicative capacity was defined as the minimum time required for p24 antigen to bec


Increased number of single-LTR HIV-1 DNA junctions correlates with HIV-1 antigen expression and CD4+ cell decline in vivo.
J Med Virol. 1995 Jan;45(1):91-8. Unique Identifier : AIDSLINE MED/95230259
Jurriaans S; de Ronde A; Dekker J; Cornelissen M; Goudsmit J; Human Retrovirus Laboratory, Academic Medical Center, University; of Amsterdam, The Netherlands.
Human immunodeficiency type 1 (HIV-1) DNA in peripheral blood cells of HIV-1 infected individuals may be present as integrated and/or unintegrated DNA. Several reports have indicated that a major proportion of HIV-1 DNA in the asymptomatic phase is linear, full-length, and unintegrated and in the symptomatic phase eit


Effects of experience and juvenile hormone on the organization of the mushroom bodies of honey bees.
J Neurobiol. 1995 Jan;26(1):130-44. Unique Identifier : AIDSLINE MED/95230285
Withers GS; Fahrbach SE; Robinson GE; University of Virginia Health Sciences Center, Charlottesville; 22903.
There is an age-related division of labor in the honey bee colony that is regulated by juvenile hormone. After completing metamorphosis, young workers have low titers of juvenile hormone and spend the first several weeks of their adult lives performing tasks within the hive. Older workers, approximately 3 weeks of age


HIV risk status and preventive behaviors among 17,619 women.
J Obstet Gynecol Neonatal Nurs. 1995 Jan;24(1):33-9. Unique Identifier : AIDSLINE MED/95230404
Lauver D; Armstrong K; Marks S; Schwarz S; University of Wisconsin-Madison, School of Nursing 53792, USA.
OBJECTIVES: To document the percentage of women at high risk for human immunodeficiency virus (HIV) infection among primary care clients, identify their most prevalent risk factors for HIV infection, and examine the relationships between risk status and preventive behaviors for HIV infection. DESIGN: Cross-sectional.


Psychosocial factors in HIV-infected men examined [news]
J Psychosoc Nurs Ment Health Serv. 1994 Dec;32(12):49. Unique Identifier : AIDSLINE MED/95230632
[Angiocentric lymphoma associated with anemia secondary to parvovirus B19 infection]
Rinsho Ketsueki. 1995 Feb;36(2):134-40. Unique Identifier : AIDSLINE MED/95230901
Nishikori M; Noda K; Nagai T; Kurokawa I; Okamura A; Department of Internal Medicine, Hyogo Prefectural Tsukaguchi; Hospital.
A 50-year-old woman was admitted to our hospital in May 1993 because of papules, cervical lymphadenopathy and interstitial pneumonia. Oxygen inhalation and pulse therapy of corticosteroid were started. A biopsy of the left inguinal lymphnode showed T zone enlargement and marked vascularization with polymorphous atypic


[Progression of HIV infection in a cohort of hemophiliacs over an 11-year period]
Med Clin (Barc). 1995 Mar 25;104(11):411-4. Unique Identifier : AIDSLINE MED/95231084
Altisent Roca C; Ayestaran Altuna A; Tusell Puigbert JM; Oliveras Martin J; Montoro Ronsano JB; Vila Baucells M; Unidad de Hemofilia, Hospital General Universitari Vall d'Hebron,; Barcelona.
BACKGROUND: The progression of HIV infection in a cohort of hemophiliacs was evaluated taking into consideration the particularities of the natural history of HIV in this population and comparing the same with that described for other series of hemophiliacs and other risk groups for HIV infection. METHODS: A cohort of


[Human lymphotropic virus type I (HTLV-I)]
Med Clin (Barc). 1995 Mar 25;104(11):426-35. Unique Identifier : AIDSLINE MED/95231089
Vallejo A; Soriano V; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.
[Oral Kaposi's sarcoma: role of radiotherapy (letter)]
Med Clin (Barc). 1995 Mar 25;104(11):436-7. Unique Identifier : AIDSLINE MED/95231091
Conill C; Verger E; Ferrer F; Ferre J
The glimmer of HIV proteinase inhibitors [comment] [see comments]
Lancet. 1995 Apr 15;345(8955):936-7. Unique Identifier : AIDSLINE MED/95231113
Lipsky JJ; Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Safety and activity of saquinavir in HIV infection [see comments]
Lancet. 1995 Apr 15;345(8955):952-5. Unique Identifier : AIDSLINE MED/95231119
Kitchen VS; Skinner C; Ariyoshi K; Lane EA; Duncan IB; Burckhardt J; Burger HU; Bragman K; Pinching AJ; Weber JN; Department of Genito-Urinary Medicine & Communicable Diseases, St; Mary's Hospital Medical School, London, UK.
We evaluated saquinavir, an orally active, selective inhibitor of HIV proteinase, in a randomised, double-blind, dose-ranging study in 49 zidovudine-naive HIV-positive patients with few or no symptoms and CD4 cell counts of 500 or less. The study was designed to assess the antiviral activity and tolerability of saquin


HTLV screening of Swedish blood donors [news] [published erratum appears in Lancet 1995 May 13;345(8959):1250]
Lancet. 1995 Apr 15;345(8955):978. Unique Identifier : AIDSLINE MED/95231129
Giesecke J
Transmission of HIV [letter; comment]
Lancet. 1995 Apr 15;345(8955):988. Unique Identifier : AIDSLINE MED/95231144
Murphy DJ; Mulcahy F
HIV-1 subtypes and male-to-female transmission in Thailand.
Lancet. 1995 Apr 29;345(8957):1078-83. Unique Identifier : AIDSLINE MED/95231169
Kunanusont C; Foy HM; Kreiss JK; Rerks-Ngarm S; Phanuphak P; Raktham S; Pau CP; Young NL; Department of Communicable Disease Control, Ministry of Public; Health, Nonthaburi, Thailand.
We examined the risk factors for heterosexual transmission of HIV in a case-control study of couples in Thailand . 90 HIV-positive men and their regular sex partners were enrolled at the immune clinic, Chulalongkorn Hospital, where 92% of male index cases had HIV-1 serotype A (sub


Routine testing of HIV status of babies? [news]
Lancet. 1995 Apr 29;345(8957):1102. Unique Identifier : AIDSLINE MED/95231178
Harrigan P
Treatment of children with HIV infection. PENTA (Paediatric European Network for Treatment of AIDS) [letter; comment]
Lancet. 1995 Apr 29;345(8957):1115. Unique Identifier : AIDSLINE MED/95231193
Gibb DM; Darbyshire JH; Debre M; Giaquinto C; Aboulker JP; Martinez M; Tudor-Williams G
Lymphoma of the head and neck and acquired immunodeficiency syndrome: clinical investigation and immunohistological study.
Laryngoscope. 1995 Apr;105(4 Pt 2 Su 68):1-18. Unique Identifier : AIDSLINE MED/95231235
Finn DG; Department of Otolaryngology--Head and Neck Surgery, New York Eye; and Ear Infirmary/New York Medical College, USA.
The epidemic of acquired immunodeficiency syndrome (AIDS) has made an enormous impact in the practice of medicine within the past decade. Of the many associated problems, the increasing frequency of human immunodeficiency virus (HIV)-related malignancies, particularly lymphoma, has been both a fascinating area of stud


[Comparison of intestinal parasite infestation indexes among HIV positive and negative populations]
Medicina (B Aires). 1994;54(4):307-10. Unique Identifier : AIDSLINE MED/95231270
Mendez OC; Szmulewicz G; Menghi C; Torres S; Gonzalez G; Gatta C; Hospital de Clinicas Jose de San Martin, Facultad de Medicina,; Universidad de Buenos Aires, Argentina.
This study was carried out on two groups of patients treated at the Jose de San Martin Clinical Hospital. One group was composed of 82 HIV-seropositive patients with no signs of diarrhea, and another one of 300 patients, not suspected of HIV infection, was considered as control population. Stool samples were collected


Tuberculosis in Australia, 1989-1992. Bacteriologically confirmed cases and drug resistance [see comments]
Med J Aust. 1995 Mar 20;162(6):287-90. Unique Identifier : AIDSLINE MED/95231333
Dawson DJ; Cheah DF; Chew WK; Haverkort FC; Lumb R; Sievers AS; Laboratory of Microbiology and Pathology, Queensland Health,; Brisbane.
OBJECTIVE: To collate statistics, including drug susceptibility, of patients with bacteriologically confirmed tuberculosis in Australia during 1989-1992. DESIGN: Collaborative project among the five Australian mycobacterial reference laboratories. STUDY POPULATION: 2509 Australi


Infectious diarrhoea revisited [see comments]
Med J Aust. 1995 Mar 20;162(6):314-7. Unique Identifier : AIDSLINE MED/95231341
Richards MJ; Crotty B; Infectious Disease Services, Austin Repatriation Hospital,; Melbourne, VIC.
[The role of opportunistic protozoa in human pathology today]
Med Parazitol (Mosk). 1994 Oct-Dec;(4):3-8. Unique Identifier : AIDSLINE MED/95231402
Lysenko AIa
The paper deals with opportunistic protozoa, their common properties distinctions from commensals and obligate parasites, and the specific features of their caused opportunistic infections. It also provides evidence for the increasing contribution of opportunistic protozoa to human pathology today and for paramount ne


SA AIDS comic Roxy [news]
Nurs RSA. 1994 Oct;9(10):4. Unique Identifier : AIDSLINE MED/95231586
Disinfectants: the whats and wherefores? [letter]
Nurs RSA. 1994 Nov-Dec;9(11-12):2. Unique Identifier : AIDSLINE MED/95231591
Mapping the AIDS pandemic: geographical progression of HIV in South Africa 1990-93.
Nurs RSA. 1994 Sep;9(9):20-1. Unique Identifier : AIDSLINE MED/95231597
Webb D
Immune reactions following systemic immunization prior or subsequent to intrastriatal transplantation of allogeneic mesencephalic tissue in adult rats.
Neuroscience. 1995 Feb;64(3):629-41. Unique Identifier : AIDSLINE MED/95231704
Duan WM; Widner H; Frodl EM; Brundin P; Department of Neurology, University Hospital, Lund, Sweden.
We have previously found that dissociated mesencephalic tissue, which differs from the host at both major histocompatibility complex and non-major histocompatibility complex gene loci, can survive stereotaxic transplantation to the striatum of adult rats. We have now studied the outcome of intrastriatal neural allogra


Sexually transmitted diseases and HIV infection.
Nurse Pract. 1995 Feb;20(2):66-71. Unique Identifier : AIDSLINE MED/95231804
Hepatitis C prevalence and needle/syringe sharing behaviours in recent onset injecting drug users.
N Z Med J. 1995 Mar 22;108(996):103-5. Unique Identifier : AIDSLINE MED/95231810
Robinson GM; Reynolds JN; Robinson BJ; Wellington Drug Clinic.
AIM. To investigate the prevalence of hepatitis C antibody (anti-HCV) in injecting drug users (IDU), particularly amongst those of recent onset beginning since the advent of the needle-exchange programme. Secondly this study sought information on needle-sharing practices. METHODS. The records of injecting drug users o


Responses to hepatitis B vaccine boosters in human immunodeficiency virus-infected children.
Pediatr Infect Dis J. 1995 Jan;14(1):65-7. Unique Identifier : AIDSLINE MED/95231938
Choudhury SA; Peters VB; Department of Pediatrics, Mount Sinai School of Medicine, New; York, NY, USA.
Immune complex-dissociated p24 antigenemia in the diagnosis of human immunodeficiency virus infection in vertically infected Brazilian children.
Pediatr Infect Dis J. 1995 Jan;14(1):67-9. Unique Identifier : AIDSLINE MED/95231939
Nielsen K; Santos E; Rubini N; Sales W; Sion F; Sa CA; Detels R; Wei L; Bryson Y; Department of Pediatrics, UCLA School of Medicine, USA.
Depression in life-threatening illness and its treatment.
Nurs Times. 1995 Mar 15-21;91(11):41-3. Unique Identifier : AIDSLINE MED/95231962
Saunders P
Health-care professionals may feel at a loss when caring for the individual faced with a life-threatening illness who is also depressed, and may even consider that depression in such circumstances is inevitable. Assessment of the individual s mental state may be made difficult by physical symptoms and other factors, m


Number of women using HIV services on the rise [news]
Nurs Times. 1995 Mar 15-21;91(11):8. Unique Identifier : AIDSLINE MED/95231971
Nurses' role in supporting people who are HIV positive.
Nurs Times. 1995 Mar 22-8;91(12):37-9. Unique Identifier : AIDSLINE MED/95231980
Firn S; Norman I
This is the second of two papers which report the results of a research study of the psychological and emotional needs of people with HIV disease and how nurses might best offer support. This paper discusses the nurse s role in offering psychological and emotional support to patients. Inductive analysis of in-depth in


Pulmonary tuberculosis. Is resurgence due to reactivation or new infection?
Postgrad Med. 1995 Apr;97(4):35-8, 44, 47-8. Unique Identifier : AIDSLINE MED/95232040
Colice GL; Duke University School of Medicine, Durham, North Carolina, USA.
Spread of tuberculosis consists of three phases: In the transmission phase, Mycobacterium tuberculosis is transferred from a source of a host via aerosolization of respiratory secretions. During the infective phase, the organism establishes itself within the lung of the new host. In the pathogenetic phase, organism- a


Psoriatic arthritis. Diverse and sometimes highly destructive.
Postgrad Med. 1995 Apr;97(4):97-9, 103-6, 108. Unique Identifier : AIDSLINE MED/95232044
Bulbul R; Williams WV; Schumacher HR Jr; Rheumatology Division, University of Pennsylvania School of; Medicine, Philadelphia, USA.
Psoriatic arthritis is an inflammatory arthritis with diverse clinical manifestations. Certain subsets of patients tend to run a more severe course of erosive disease. A few points are noteworthy: When a diagnosis of psoriatic arthritis is being considered, ask if there is any family history of psoriasis and search fo


Treatment and prevention of chronic viral hepatitis.
Pharmacol Ther. 1995 Jan;65(1):47-73. Unique Identifier : AIDSLINE MED/95232136
Dusheiko GM; Royal Free Hospital and School of Medicine, London, U.K.
Chronic viral hepatitis caused by hepatitis B, C or D may lead to cirrhosis, hepatocellular failure and hepatocellular carcinoma. The morbidity of these diseases has necessitated a prolonged search for effective therapy. Interferon-alpha has been studied widely, and remains the mainstay of treatment. Therapy for hepat


[Ultrasound aspects in AIDS-related splenic diseases]
Radiol Med (Torino). 1995 Jan-Feb;89(1-2):100-4. Unique Identifier : AIDSLINE MED/95232246
Cecconi L; Schinina V; Busi Rizzi E; Mazzuoli G; Servizio di Radiologia, Ospedale Lazzaro Spallanzani, Roma.
The authors reviewed retrospectively 139 splenopathies detected during 432 US examinations of the abdomen in AIDS patients to assess the role of US in correlation with anamnestic-clinical data and histologic findings in 45 cases. Splenomegaly was the main sign of abnormal splenic conditions, since it was present in al


[Attitudes towards AIDS. A questionnaire for health professionals]
Rev Enferm. 1995 Mar;18(199):23-8. Unique Identifier : AIDSLINE MED/95232358
Gala Leon FJ; Diaz Rodriguez M; Martinez Nieto JM; Barba Chacon A; Lupiani Jimenez M; Paublete Herrera CP
[Estimation of AIDS morbidity and mortality in Spain]
Rev Sanid Hig Publica (Madr). 1994 Jan-Feb;68(1):179-85. Unique Identifier : AIDSLINE MED/95232384
Castilla Catalan J; Gutierrez Rodriguez A; Sendra Gutierrez JM; Garcia Puente E; Centro Nacional de Epidemiologia, Instituto de Salud Carlos III,; Madrid.
BACKGROUND: To obtain corrected estimates of the cumulative incidence and mortality, as well as prevalence of AIDS in Spain on June 1992. METHODS: The number of cases in the National Register of AIDS by December 1992 was adjusted for reporting delays to estimate the cumulative incid


A comparison of the progression rate to acquired immunodeficiency syndrome between intravenous drug users and homosexual men.
Scand J Soc Med. 1994 Dec;22(4):309-14. Unique Identifier : AIDSLINE MED/95232421
Eskild A; Magnus P; Sohlberg C; Jensen F; Kittelsen P; Department of Epidemiology, National Institute of Public Health,; Oslo, Norway.
In order to study differences in progression to Acquired Immunodeficiency Syndrome (AIDS) between risk groups, 205 homosexual men and 185 intravenous drug users (IVDUs) were followed from diagnosed seropositivity for Human Immunodeficiency Virus Type-1 (HIV) for a mean period of 46 months (range 1-88 months). Seven (4


[Toxoplasmosis and ocular pathology]
Schweiz Med Wochenschr Suppl. 1995;65:82S-88S. Unique Identifier : AIDSLINE MED/95232435
Schnyder CC; Hopital ophtalmique Jules Gonin, Lausanne.
Toxoplasmosis is the leading cause of posterior uveitis in the immunocompetent adult, and potentially leads to blindness. Ocular Toxoplasmosis is usually considered a recurrence of a congenital infection, and this fact enhances the importance of prevention in pregnant women in order to avoid transplacental passage of


A movable institute: the AIDS dream team [news]
Science. 1995 Apr 14;268(5208):191. Unique Identifier : AIDSLINE MED/95232487
Congressman uncovers the HIV conspiracy [news]
Science. 1995 Apr 14;268(5208):191. Unique Identifier : AIDSLINE MED/95232488
AIDS research. Cytokines move from the margins into the spotlight [news]
Science. 1995 Apr 14;268(5208):205-6. Unique Identifier : AIDSLINE MED/95232493
Balter M
AIDS data [letter; comment]
Science. 1995 Apr 21;268(5209):350-2. Unique Identifier : AIDSLINE MED/95232513
Duesberg P
AIDS therapy. New hope against blindness [news]
Science. 1995 Apr 21;268(5209):368-9. Unique Identifier : AIDSLINE MED/95232521
Cohen J
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein.
Science. 1995 Apr 21;268(5209):429-31. Unique Identifier : AIDSLINE MED/95232534
Li CJ; Friedman DJ; Wang C; Metelev V; Pardee AB; Division of Cell Growth and Regulation, Dana-Farber Cancer; Institute, Boston, MA, USA.
Infection by human immunodeficiency virus-type 1 (HIV-1) is typified by the progressive depletion of CD4 T lymphocytes and deterioration of immune function in most patients. A central unresolved issue in acquired immunodeficiency syndrome (AIDS) pathogenesis is the mechanism underlying this T cell depletion. HIV-1 Tat


Profile of HIV disease in an American border city.
South Med J. 1995 Apr;88(4):429-32. Unique Identifier : AIDSLINE MED/95232582
Verghese A; Nabhan D; Escobedo MA; Guardado J; Guerra LG; Ho H; Casner P; Berk ML; Department of Internal Medicine, Texas Tech University Health; Sciences Center, El Paso 79905-1298, USA.
A previous study on patterns of migration of HIV-infected persons suggested that most patients in a rural setting in eastern Tennessee acquired their disease in an urban area, typically during a period of prolonged residence. Disease and disability were the most common reasons for returning to their hometown. We studi


Vitiligo and alopecia areata in patients with human immunodeficiency virus infection.
South Med J. 1995 Apr;88(4):489-91. Unique Identifier : AIDSLINE MED/95232597
Cho M; Cohen PR; Duvic M; Department of Dermatology, University of Texas Medical School at; Houston 77030, USA.
In patients infected with human immunodeficiency virus (HIV) the development of autoimmune diseases, while not life threatening, is an interesting phenomenon that may result from immune dysfunction or from B cell infection by HIV, Epstein-Barr virus, or other unknown viruses. Vitiligo and alopecia areata are among the


Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues--evidence for a function for envelope gene products.
Ups J Med Sci. 1994;99(2):113-20. Unique Identifier : AIDSLINE MED/95232827
Larsson E; Andersson AC; Nilsson BO; Department of Pathology, Uppsala University Hospital, Sweden.
ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. It is expressed in several human tissues as LTR env spliced transcripts (9 and 3.5 kb). The highest level of expression is to be found in placenta and virus expression is down-regulated in choriocarcinoma cell lines. By me


[Activation of viral reproduction in a mixed infection with human immunodeficiency virus and herpes viruses]
Vopr Virusol. 1994 Sep-Oct;39(5):223-6. Unique Identifier : AIDSLINE MED/95232923
Barinskii IF; Nosik DN; Kal'nov SL; Nikitina AA; L'vov ND; Petrova MS; Tsibezov VV
Mutual activation of reproduction of type 1 HIV and herpes simplex types 1 and 2 viruses (HSV) was observed in simultaneous infection of continuous T-cellular lymphoblastoid lines (CEM, 119, Hut-78, MT-4, Jurkat-tat) and U-937 monocytic line. Syncytium formation and cytodestructive pattern of reproduction of viruses o


[A nonisotopic method of quantitative PCR analysis in diagnosing HIV infection]
Vopr Virusol. 1994 Nov-Dec;39(6):242-5. Unique Identifier : AIDSLINE MED/95232928
Radiuk SN; Matsevich GR; Andzhaparidze OG
A nonisotopic method for the detection of HIV DNA has been developed, based on the use of avidin-biotin complex to identify the products of polymerase chain reaction (PCR). Biotin label integrated in deoxyuridine triphosphate (bio-11-dUTP) was incorporated in the structure of amplified fragments in the course of PCR.


[Amplification of the activity of HIV-1 isolates purified from seropositive children after cryopreservation of persistently-infected cells]
Vopr Virusol. 1994 Nov-Dec;39(6):251-4. Unique Identifier : AIDSLINE MED/95232931
Selimova LM; Iurin OG; Irova TI; Gushchina EA; Kuznetsova VV; Pokrovskii VV; Uryvaev LV; L'vov DK
HIV-1 strains MC-1974 and MC-1978 were isolated from children infected in hospital. Both children presented with symptoms of HIV infection by the moment the blood samples for virus isolation were collected. In vitro the isolated strains showed weak infective activity and caused no cytopathic effect in sensitive cells.


[Study of the anti-HIV activity of miramistin]
Vopr Virusol. 1994 Nov-Dec;39(6):267-9. Unique Identifier : AIDSLINE MED/95232937
Krivorutchenko IuL; KrivosheinIuS; Marennikova SS; Stepanova LG; Nosik DN; Kalnina LB; Rud'ko AP
The anti-HIV activity of a cationic detergent myramistin and nonionic detergent dezintegron-0 (d-0) was studied using HIV-1 strains III B/H9 and BRU in lymphoblastoid cells MT-4 and Jurkat-tat. Myramistin in a concentration of 0.075 mg/ml was shown to prevent HIV-1 replication in MT-4 when these cells were cocultivate


[Isolation of human B-cells, specific for viral peptides, using magnetic spheres]
Vopr Virusol. 1994 Nov-Dec;39(6):272-4. Unique Identifier : AIDSLINE MED/95232939
Sidorova EV; Borisova TK; Rozen A
A method for isolation of human B cells specific to viral peptides using magnetic beads has been developed. The method was used for the isolation from human tonsils of B cells specific to HIV-1 gp 120 MN-24 peptide (residues 302-322) and to Epstein-Barr virus 107 EBNA-1 peptide. The cells selected with beads were tran


[The effect of fetal calf serum on the anti-HIV properties of miramistin]
Vopr Virusol. 1994 Nov-Dec;39(6):281-3. Unique Identifier : AIDSLINE MED/95232943
Krivorutchenko IuL; Krivoshein IuS; Andronovskaia IB; Nosik DN; Kalnina LB; Petrova MS
The anti-HIV activity of an antiseptic miramistin in the presence of fetal calf serum (FCS) was studied. It has been recently shown that cation detergent miramistin at a concentration of 100 micrograms/ml prevented HIV-1 replication in MT-4 cells when these cells were cocultivated with MT-4 cells previously infected a


[Tuberculosis of the esophagus]
Wien Klin Wochenschr. 1995;107(5):155-7. Unique Identifier : AIDSLINE MED/95232984
Monig SP; Schmidt R; Wolters U; Krug B; Klinik und Poliklinik fur Chirurgie, Universitat zu Koln,; Bundesrepublik Deutschland.
Tuberculosis of the esophagus is a rare disease, occurring in most cases secondary to tuberculous infection of other organs. There are neither characteristic symptoms or diagnostic signs, nor typical X-ray or laboratory findings. Histology, too, often fails to establish a reliable diagnosis, so that esophageal tubercu


[The physician's responsibility in patient education in HIV infection]
Z Arztl Fortbild (Jena). 1994 Dec;88(12):1002-8; discussion 1008-14. Unique Identifier : AIDSLINE MED/95232992
Rieger HJ
[Confidence between patient comprehension and the physician's capacity to educate ]
Z Arztl Fortbild (Jena). 1994 Dec;88(12):987-94. Unique Identifier : AIDSLINE MED/95233008
Bochnik HJ; Zentrum der Psychiatrie, Universitat, Frankfurt/M.
Pneumocystis carinii pneumonia.
AJR Am J Roentgenol. 1995 May;164(5):1098. Unique Identifier : AIDSLINE MED/95233241
Gervais DA; Whitman GJ; Chew FS; Department of Radiology, Massachusetts General Hospital, Boston,; USA.
Hepatic manifestations of porphyria cutanea tarda in a patient with AIDS.
Am J Gastroenterol. 1995 Apr;90(4):658-9. Unique Identifier : AIDSLINE MED/95233364
Sepkowitz DV; Hennessey P; Torno RB; Lampert MA; Division of Infectious Disease, Long Island College Hospital,; Brooklyn, New York, USA.
Transfer of neuropathogenic simian immunodeficiency virus with naturally infected microglia.
Am J Pathol. 1995 Apr;146(4):914-23. Unique Identifier : AIDSLINE MED/95233499
Watry D; Lane TE; Streb M; Fox HS; Department of Neuropharmacology, Scipps Research Institute, La; Jolla, California 92037, USA.
The central nervous system (CNS) is a target for human immunodeficiency virus infection, and, in individuals with acquired immune deficiency syndrome, this can lead to a devastating dementia . Only certain viral variants appear capable of invading the CNS and infecting microglia and


Different subsets of T cells in conjunction with natural killer cells, macrophages, and activated microglia participate in the intracerebral immune response to Toxoplasma gondii in athymic nude and immunocompetent rats.
Am J Pathol. 1995 Apr;146(4):999-1007. Unique Identifier : AIDSLINE MED/95233508
Schluter D; Hein A; Dorries R; Deckert-Schluter M; Department of Medical Microbiology and Hygiene, Heidelberg; University, Mannheim Clinic, Germany.
Oral infection of athymic nude and immunocompetent Lewis rats with Toxoplasma gondii induced a chronic nonlethal encephalitis. The histopathological pattern of Toxoplasma encephalitis was significantly different in both groups of animals and there were substantially larger numbers of Toxoplasma cysts in the brains of


Intermittent trimethoprim-sulfamethoxazole compared with dapsone-pyrimethamine for the simultaneous primary prophylaxis of Pneumocystis pneumonia and toxoplasmosis in patients infected with HIV [see comments]
Ann Intern Med. 1995 May 15;122(10):755-61. Unique Identifier : AIDSLINE MED/95233645
Podzamczer D; Salazar A; Jimenez J; Consiglio E; Santin M; Casanova A; Rufi G; Gudiol F; Infectious Disease Service, Ciutat Sanitaria de Bellvitge,; Barcelona, Spain.
OBJECTIVE: To evaluate the efficacy and safety of two oral, intermittent drug regimens for the simultaneous primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmosis in patients with HIV infection. DESIGN: Nonblinded randomized study: Patients received either 1) trimethoprim-sulfamethoxazole (160 mg-800


The effect of cellular energetics on foreign protein production.
Appl Biochem Biotechnol. 1995 Feb;50(2):145-59. Unique Identifier : AIDSLINE MED/95233757
Ko YF; Bentley WE; Weigand WA; Department of Chemical Engineering, University of Maryland,; College Park 20742.
Escherichia coli strain F-122 was used to determine if there are additional physiological effects, other than decreasing energetic efficiency accompanied by the excretion of the acetate, on foreign protein production. This organism was the host for expressing HIV582-beta-galactosidase fusion protein under the control


Cytomegalovirus retinitis in AIDS.
Arch Dis Child. 1995 Jan;72(1):54-5. Unique Identifier : AIDSLINE MED/95233791
Peters MJ; Moeller HU; Russell-Eggitt I; Novelli V; Great Ormond Street Hospital for Children NHS Trust, London.
Cytomegalovirus retinitis is common in adults with AIDS but has been reported infrequently in children with perinatally acquired HIV infection. The cases are presented of two infants with vertically acquired HIV infection who developed disseminated cytomegalovirus infection and ret


Who decides who decides? When disagreement occurs between the physician and the patient's appointed proxy about the patient's decision-making capacity.
Arch Intern Med. 1995 Apr 24;155(8):793-6. Unique Identifier : AIDSLINE MED/95233840
Schneiderman LJ; Teetzel H; Department of Family and Preventive Medicine, University of; California, San Diego, La Jolla 92093-0622, USA.
Changes in survival over time after a first episode of Pneumocystis carinii pneumonia for European patients with acquired immunodeficiency syndrome. Multicentre Study Group on AIDS in Europe.
Arch Intern Med. 1995 Apr 24;155(8):822-8. Unique Identifier : AIDSLINE MED/95233844
Lundgren JD; Barton SE; Katlama C; Ledergerber B; Gonzalez-Lahoz J; Pinching AJ; Proenca R; Hemmer R; Pedersen C; Phillips AN; Hvidovre (Denmark) Hospital, University of Copenhagen.
BACKGROUND: Factors associated with improved survival over time for patients with the acquired immunodeficiency syndrome (AIDS) who have Pneumocystis carinii pneumonia at diagnosis are not clearly defined. METHODS: An inception cohort of 2533 patients with AIDS, diagnosed from 1979 to 1989, from 52 centers in 17 Europ


Tuberculosis in health care workers at a hospital with an outbreak of multidrug-resistant Mycobacterium tuberculosis.
Arch Intern Med. 1995 Apr 24;155(8):854-9. Unique Identifier : AIDSLINE MED/95233848
Jereb JA; Klevens RM; Privett TD; Smith PJ; Crawford JT; Sharp VL; Davis BJ; Jarvis WR; Dooley SW; Centers for Disease Control and Prevention, Atlanta, Ga., USA.
OBJECTIVE: Investigate reports of tuberculosis in health care workers employed at a hospital with an outbreak of multidrug-resistant Mycobacterium tuberculosis. DESIGN: Case series of tuberculosis in health care workers, January 1, 1989, through May 31, 1992. Antimicrobial susceptibility testing and restriction fragme


Pneumocystis carinii pneumonia during immunosuppressive therapy for antineutrophil cytoplasmic autoantibody-positive vasculitis.
Arch Intern Med. 1995 Apr 24;155(8):872-4. Unique Identifier : AIDSLINE MED/95233851
Huynh-Do U; Gantenbein H; Binswanger U; Department of Internal Medicine, University Hospital, Zurich,; Switzerland.
We describe two human immunodeficiency virus-negative patients who developed Pneumocystis carinii pneumonia (PCP) during immunosuppressive therapy for antineutrophil cytoplasmic autoantibody-positive vasculitis and review the literature regarding the pathogenesis and frequency of PCP. The recent application of DNA amp


Noninvasive long-term ventilatory support for individuals with spinal muscular atrophy and functional bulbar musculature.
Arch Phys Med Rehabil. 1995 Mar;76(3):213-7. Unique Identifier : AIDSLINE MED/95233865
Bach JR; Wang TG; UMD-New Jersey Medical School, Department of Physical Medicine; and Rehabilitation, West Orange, USA.
Ten individuals with spinal muscular atrophy (SMA) and chronic ventilatory insufficiency were trained in the use of assisted coughing techniques and received intermittent positive pressure ventilation (IPPV) via oral and/or nasal interfaces for a mean of 5.3 (range = 1 to 17) years. During this time they had significa


Gouty arthritis in the acquired immunodeficiency syndrome. An unusual but aggressive case.
Arthritis Rheum. 1995 Apr;38(4):570-2. Unique Identifier : AIDSLINE MED/95234078
Disla E; Stein S; Acevedo M; Cuppari G; Department of Medicine, Cabrini Medical Center, New York, NY; 10003, USA.
Patients with the acquired immunodeficiency syndrome (AIDS) are characteristically hypouricemic. Therefore, the occurrence of gouty arthritis in association with AIDS would be expected to be a rare phenomenon. We describe a patient with AIDS in whom gouty arthritis developed. Features of both diseases in relation to t


Can live attenuated virus work as post-exposure treatment?
Immunol Today. 1995 Mar;16(3):131-5. Unique Identifier : AIDSLINE MED/95234142
Bonhoeffer S; Nowak MA; Dept of Zoology, University of Oxford, UK.
Simple mathematical models for the competition between different virus variants in the presence of a crossreactive immune response show that, contrary to expectation, selection can favour variants that induce low viral loads. Here, Sebastian Bonhoeffer and Martin Nowak suggest that such competitively superior , but


Infant feeding policy and practice in the presence of HIV-1 infection [editorial]
AIDS. 1995 Feb;9(2):107-19. Unique Identifier : AIDSLINE MED/95234242
Nicoll A; Newell ML; Van Praag E; Van de Perre P; Peckham C
Retinoic acid inhibits both the basal activity and phorbol ester-mediated activation of the HIV long terminal repeat promoter.
AIDS. 1995 Feb;9(2):129-36. Unique Identifier : AIDSLINE MED/95234244
Towers G; Harris J; Lang G; Collins MK; Latchman DS; Chester Beatty Laboratories, Institute of Cancer Research,; London, UK.
OBJECTIVE: To establish whether the steroid hormone retinoic acid (RA) was able to modulate the activity of the HIV-1 promoter. DESIGN: The effect of RA and nuclear factor (NF)-kappa B on HIV-1 promoter activity was investigated using HIV-1 long terminal repeat (LTR)-based reporter constructs. METHODS: The activity of


Long-term survival without clinical AIDS after CD4+ cell counts fall below 200 x 10(6)/l.
AIDS. 1995 Feb;9(2):145-52. Unique Identifier : AIDSLINE MED/95234246
Hoover DR; Rinaldo C; He Y; Phair J; Fahey J; Graham NM; Department of Epidemiology, Johns Hopkins University, School of; Hygiene and Public Health, Baltimore, MD 21205, USA.
OBJECTIVE: Quantify and study cofactors of long-term survival without AIDS in HIV-1-infected individuals with CD4+ cell counts


Improved brain delivery and in vitro activity of zidovudine through the use of a redox chemical delivery system.
AIDS. 1995 Feb;9(2):153-8. Unique Identifier : AIDSLINE MED/95234247
Mizrachi Y; Rubinstein A; Harish Z; Biegon A; Anderson WR; Brewster ME; Division of Allergy and Immunology, Albert Einstein College of; Medicine, Bronx, NY 10461-1602, USA.
OBJECTIVE: Improved therapy for AIDS dementia and related encephalopathies may be achieved through enhanced delivery of effective antiretroviral agents to the central nervous system (CNS). DESIGN: A novel chemical delivery system (CDS) was used, which utilized redox trapping of dru


Response of HIV RNA to didanosine as a predictive marker of survival.
AIDS. 1995 Feb;9(2):159-63. Unique Identifier : AIDSLINE MED/95234248
Yerly S; Kaiser L; Mermillod B; Baumberger C; Hirschel B; Perrin L; Central Laboratory of Virology, Geneva University Hospital,; Switzerland.
OBJECTIVE: To evaluate whether early changes in viraemia in response to didanosine (ddI) predict death and occurrence of new AIDS-defining events. METHODS: Forty-three patients were followed during ddI treatment with sequential determinations of serum viraemia, mutations associated with drug resistance, CD4 counts and


HIV infection and drug use: influence on cognitive function.
AIDS. 1995 Feb;9(2):165-70. Unique Identifier : AIDSLINE MED/95234249
Grassi MP; Clerici F; Perin C; Zocchetti C; Borella M; Cargnel A; Mangoni A; Department of Neurology, L. Sacco Hospital, Milan, Italy.
OBJECTIVE: To examine the involvement of cognitive function in HIV-seropositive drug users (DU) in a pre-AIDS state. DESIGN: Fifty-six HIV-positive DU were prospectively evaluated. They belonged to groups II, III and IV (subgroups A, C2 and E) of the 1987 Centers for Disease Control and Prevention classification, with


Same-sex behavior, sexually transmitted diseases and HIV risks among young northern Thai men.
AIDS. 1995 Feb;9(2):171-6. Unique Identifier : AIDSLINE MED/95234250
Beyrer C; Eiumtrakul S; Celentano DD; Nelson KE; Ruckphaopunt S; Khamboonruang C; Johns Hopkins University, School of Hygiene and Public Health,; Baltimore, Maryland, USA.
OBJECTIVES: To assess the risks for HIV infection and sexually transmitted diseases (STD) among young northern Thai men who have sex with men (MSM), and to examine the possible role of male same-sex behavior in the northern Thai HIV/AIDS epidemic. METHODS: Two cohorts of northern Thai military conscripts and one cohor


Increasing HIV-1 seroprevalence associated with genital ulcer disease, New York City, 1990-1992.
AIDS. 1995 Feb;9(2):177-81. Unique Identifier : AIDSLINE MED/95234251
Torian LV; Weisfuse IB; Makki HA; Benson DA; DiCamillo LM; Toribio FE; Office of AIDS Research and HIV Serosurveys, New York City; Department of Health, NY 10013, USA.
OBJECTIVE: To measure HIV seroprevalence trends associated with sexually transmitted diseases (STD) causing ulcerative lesions [genital ulcer disease (GUD)], such as syphilis, chancroid and genital herpes , in New York City between 1990 and 1992. DESIGN: Unlinked HIV-1 serosurvey


Imprisonment: a risk factor for HIV infection counteracting education and prevention programmes for intravenous drug users.
AIDS. 1995 Feb;9(2):183-90. Unique Identifier : AIDSLINE MED/95234252
Muller R; Stark K; Guggenmoos-Holzmann I; Wirth D; Bienzle U; Institute of Medical Statistics, Free University of Berlin,; Germany.
OBJECTIVES: To examine changes of risk behaviour and its determinants as well as risk factors for HIV infection in intravenous drug users (IVDU) with particular attention to imprisonment and its risk patterns. SETTING: In 1993 a multisite cross-sectional study was carried out by standardized questionnaires and blood/s


HIV prevalence and risk factors in university students.
AIDS. 1995 Feb;9(2):191-7. Unique Identifier : AIDSLINE MED/95234253
Raab GM; Burns SM; Scott G; Cudmore S; Ross A; Gore SM; O'Brien F; Shaw T; Medical Research Council Biostatistics Initiative for HIV and; AIDS Studies in Scotland, Centre for HIV Research.
OBJECTIVE: To estimate HIV prevalence and risks in university students. DESIGN: Anonymous self-completion questionnaire and HIV survey with saliva samples. SETTING: University students at matriculation. PARTICIPANTS: All first and third year undergraduates and newly registering postgraduates at the University of Edinb


Reduced frequency of percutaneous injuries in surgeons: 1993 versus 1988.
AIDS. 1995 Feb;9(2):199-202. Unique Identifier : AIDSLINE MED/95234254
Lowenfels AB; Mehta V; Levi DA; Montecalvo MA; Savino JA; Wormser GP; Department of Surgery, New York Medical College, Valhalla 10595,; USA.
OBJECTIVE: To compare the frequency of occupational injuries reported by surgeons in 1993 with similar data obtained in 1988. DESIGN AND SETTING: Two point-prevalence studies of percutaneous injuries of surgeons practicing in tertiary and non-tertiary-care hospitals in the New York metropolitan area. PARTICIPANTS: A t


T lymphocytes with gamma/delta T-cell receptors in patients with AIDS and Pneumocystis carinii pneumonia [letter; comment]
AIDS. 1995 Feb;9(2):203-4. Unique Identifier : AIDSLINE MED/95234255
Agostini C; Zambello R; Trentin L; Semenzato G
Zidovudine to decrease mother-to-child transmission of HIV-1: is it good for developing countries? [letter]
AIDS. 1995 Feb;9(2):204-6. Unique Identifier : AIDSLINE MED/95234256
Dabis F; Mandelbrot L; Msellati P; Van de Perre P
Kaposi's sarcoma involving bone in a patient with AIDS [letter]
AIDS. 1995 Feb;9(2):206-8. Unique Identifier : AIDSLINE MED/95234257
Horusitzky A; Cariou D; Chicheportiche V; Brice P; Aerts J; Ziza JM; Raguin G
Octreotide therapy in AIDS-related, refractory diarrhea: results of a multicentre Canadian-European study. Octreotide International Multicentre AIDS-Diarrhea Study [letter]
AIDS. 1995 Feb;9(2):209-10. Unique Identifier : AIDSLINE MED/95234258
Montaner JS; Harris AG
The European-Australian Collaborative Group Study 017 of zidovudine versus placebo [letter; comment]
AIDS. 1995 Feb;9(2):211. Unique Identifier : AIDSLINE MED/95234259
Mulder JW; Cooper DA
HIV risk behaviour among injecting drug users in Warsaw [letter]
AIDS. 1995 Feb;9(2):211-3. Unique Identifier : AIDSLINE MED/95234260
Stark K; Sieroslawski J; Wirth D; Godwod-Sikorska C; Muller R; Bienzle U
Prostitution and HIV [letter; comment]
AIDS. 1995 Feb;9(2):213. Unique Identifier : AIDSLINE MED/95234261
Harcourt C; O'Connor C
Drug-resistant Mycobacterium tuberculosis strains in tuberculosis inpatients in Bangui, Central African Republic [letter]
AIDS. 1995 Feb;9(2):213-4. Unique Identifier : AIDSLINE MED/95234262
Garin B; Di Costanzo B; Kassa Kelembho E; Legot B; Guerin D; Ouapou-Lena F; Vohito MD; Vincent V; Mathiot C
Pathogenicity of the microsporidia [letter; comment]
AIDS. 1995 Feb;9(2):215. Unique Identifier : AIDSLINE MED/95234263
Sorvillo F; Kerndt P
Diabetes mellitus following treatment of AIDS with didanosine [letter]
AIDS. 1995 Feb;9(2):215-6. Unique Identifier : AIDSLINE MED/95234264
Chidiac C; Alfandari S; Caron J; Mouton Y
Use of prophylactic antibiotics in children.
Adv Pediatr Infect Dis. 1995;10:227-62. Unique Identifier : AIDSLINE MED/95234270
Bitar CN; Steele RW; Department of Pediatrics, Louisiana State University School of; Medicine, New Orleans, USA.
Antibiotic allergy in children.
Adv Pediatr Infect Dis. 1995;10:307-35. Unique Identifier : AIDSLINE MED/95234272
Wilson NW; West Virginia University, Department of Pediatrics, Robert S.; Byrd Health Science Center, Morgantown, USA.
Superantigens and their role in infectious disease.
Adv Pediatr Infect Dis. 1995;10:369-90. Unique Identifier : AIDSLINE MED/95234274
Schafer R; Sheil JM; Department of Microbiology and Immunology, West Virginia; University School of Medicine, Morgantown, USA.
Although the exact mechanisms by which superantigens may contribute to the pathogenesis of diseases are unknown, it seems increasingly likely that they have a role in the induction and pathogenesis of disease. The studies described here demonstrate that in several different diseases either bacterial or viral superanti


[Study on the specific binding site of NF-k B-like factor at the 5' upstream region of human lymphotoxin gene]
I Chuan Hsueh Pao. 1994;21(6):417-23. Unique Identifier : AIDSLINE MED/95234354
Xu R; Zhao S; Institute of Genetics, Fudan University Shanghai.
Lymphotoxin(LT) is a glycoprotein secreted by activated T lymphocytes. The expression of LT gene is primarily controlled at the level of transcription. By using human LT DNA as a probe, we have carried out a RNA dot blotting test and found that the longer the Jurkat cells exposed to the PMA and PHA, the more was the e


[Investigation on etiology of abnormal ratio of CD4/CD8 cells in allergic nasal mucosal epithelium]
Chung Hua Erh Pi Yen Hou Ko Tsa Chih. 1994;29(5):286-8. Unique Identifier : AIDSLINE MED/95234374
Yang P; First Affiliated Hospital, Shanxi Medical College, Taiyuan.
The lymphocytes of nasal mucosal epithelium were separated and the phenotype number of CD3, CD4 and CD8 cells were identified with immunohistochemical staining under light microscope. The number was increased significantly in CD4 cells and decreased in CD8 cells of rats nasal epithelium after stimulation with histami


Cellular and molecular aspects of organotin-induced thymus atrophy.
Hum Exp Toxicol. 1994 Dec;13(12):876-9. Unique Identifier : AIDSLINE MED/95234390
Pieters RH; Bol M; Seinen W; Penninks AH; Research Institute of Toxicology, Utrecht University, The; Netherlands.
1. Organotin compounds, di-n-butyltin dichloride (DBTC) in particular, have been shown to cause thymus atrophy in the rat. 2. DBTC-induced thymus atrophy results from a depletion of small CD4+CD8+ thymocytes which is caused by a diminished production of immature CD4-CD8+ and CD4+CD8+ thymoblasts. 3. DBTC inhibits the


Current management of primary central nervous system lymphoma.
Oncology (Huntingt). 1995 Jan;9(1):63-71; discussion 71, 75-6, 78. Unique Identifier : AIDSLINE MED/95234532
Deangelis LM; Department of Neurology, Memorial Sloan-Kettering Cancer Center,; New York, New York, USA.
Primary CNS lymphoma is rising in incidence in both the AIDS and non-AIDS populations. It is a non-Hodgkin s lymphoma that usually presents as a brain tumor, but the leptomeninges, eyes, and spinal cord also are frequently affected. Systemic lym


Modulation of specific T cell responses by concurrent infection with Leishmania major and LP-BM5 murine leukemia viruses.
Int Immunol. 1995 Jan;7(1):131-8. Unique Identifier : AIDSLINE MED/95234628
Doherty TM; Morse HC 3rd; Coffman RL; Department of Immunology, DNAX Research Institute for Cellular; and Molecular Biology, Palo Alto, CA 94304, USA.
C57BL/6 mice infected with a murine leukemia virus (MuLV) mixture designated LP-BM5 develop an immunodeficiency syndrome termed MAIDS, characterized by a variety of T and B cell abnormalities, including elevated levels of IgE, suggesting that IL-4 expression is increased in these animals. It has been suggested that th


Production of IgG autoantibodies to TCRs in mice infected with the retrovirus LP-BM5.
Int Immunol. 1995 Jan;7(1):31-6. Unique Identifier : AIDSLINE MED/95234632
Dehghanpisheh K; Huang D; Schluter SF; Watson RR; Marchalonis JJ; Department of Microbiology, University of Arizona, College of; Medicine, Tucson 85724, USA.
Autoantibodies (AAbs) directed against particular segments of the variable region of TCR beta chains occur in normal humans and in certain autoimmune diseases, but the factors regulating the appearance of such antibodies are unknown. We report that AAbs binding a peptide determinant corresponding to the CDR1 of the V


Cross-linking of the CAMPATH-1 antigen (CD52) triggers activation of normal human T lymphocytes.
Int Immunol. 1995 Jan;7(1):69-77. Unique Identifier : AIDSLINE MED/95234636
Rowan WC; Hale G; Tite JP; Brett SJ; Molecular Immunology Section, Wellcome Research Labs, Beckenham,; Kent, UK.
The CAMPATH-1 (CD52) antigen is a 21-28 kDa glycopeptide which is highly expressed on lymphocytes and macrophages and is coupled to the membrane by a glycosylphosphatidylinositol (GPI) anchoring structure. The function of this molecule is unknown. However, it is an extremely good target for complement-mediated attack


Lactate dehydrogenase-release assay: a reliable, nonradioactive technique for analysis of cytotoxic lymphocyte-mediated lytic activity against blasts from acute myelocytic leukemia.
Ann Hematol. 1995 Mar;70(3):153-8. Unique Identifier : AIDSLINE MED/95234780
Weidmann E; Brieger J; Jahn B; Hoelzer D; Bergmann L; Mitrou PS; Department of Internal Medicine, J. Goethe University Hospital,; Frankfurt/M, Germany.
Treatment of patients in remission of acute myelocytic leukemia using immunotherapy with interleukin 2 is a new approach to prolonging remission duration in this disease. As an important mechanism for the pathophysiology of eradication of residual myelocytic blast populations, activation of cytotoxic effector lymphocy


Illnesses that Australians most feared in 1986 and 1993.
Aust J Public Health. 1994 Dec;18(4):366-9. Unique Identifier : AIDSLINE MED/95234788
Borland R; Donaghue N; Hill D; Centre for Behavioural Research in Cancer, Melbourne.
This study identified illnesses Australians most feared getting, and determined whether there had been any changes between 1986 and 1993. An open-ended question about illnesses was embedded in an omnibus face-to-face survey of representative samples of Australians (1986, n = 1213; 1993, n = 1268). Cancer was by far th


Assessment of self-report in HIV surveillance: a pilot study.
Aust J Public Health. 1994 Dec;18(4):429-32. Unique Identifier : AIDSLINE MED/95234799
McDonald AM; Imrie A; Neilsen G; Downie J; Gertig DM; Robertson P; Guinan J; Mullins S; Kaldor JM; National Centre in HIV Epidemiology and Clinical Research,; Sydney.
The basis of HIV exposure category classification was investigated among selected cases of newly diagnosed HIV infection. Questionnaires seeking specific information on patient-reported exposure to HIV were forwarded to doctors who had requested the HIV antibody test for patients who met the study sample criteria. The


Prevention issues at the Tenth International Conference on AIDS.
Aust J Public Health. 1994 Dec;18(4):452-4. Unique Identifier : AIDSLINE MED/95234804
Kelaher M; National Drug and Alcohol Research Centre, University of New; South Wales, Sydney.
[Resolution with steroid therapy of an idiopathic esophageal fistula in a patient with AIDS]
An Med Interna. 1995 Jan;12(1):28-30. Unique Identifier : AIDSLINE MED/95234856
Garcia Calvo MI; Trillo Belizon C; Santalla Pecina F; Retamero Orta MD; Gomez Huelgas R; Servicio de Medicina Interna, Hospital General Basico de la; Axarquia, Velez Malaga.
We present a case of AIDS with idiopathic esophagic fistula which had a positive response to steroid therapy. We discuss the diagnostic potential and the therapeutic attitude in these cases.


[Malignant fibrous histiocytoma or pseudotumor of fusiform cell? (letter; comment)]
An Med Interna. 1995 Jan;12(1):47-8. Unique Identifier : AIDSLINE MED/95234865
Valer Corellano J
[Malignant fibrous histiocytoma or pseudotumor of fusiform cell? (letter)]
An Med Interna. 1995 Jan;12(1):48. Unique Identifier : AIDSLINE MED/95234866
Povar Marcos J; Alvarez Alegret R; Arazo Garces P; Ramos Paesa C; Aguirre Errasti JM
Monoclonal integration of HTLV-1 in pleural effusion cells in a seropositive patient with tuberculous pleuritis.
Int J Hematol. 1995 Jan;61(1):35-8. Unique Identifier : AIDSLINE MED/95234911
Chiyoda S; Kinoshita T; Miwa M; Department of Internal Medicine, Japanese Red Cross Nagasaki; Atomic Bomb Hospital, Nagasaki.
The pleural effusion of a 79-year-old man who was a carrier of human T-cell leukemia virus type 1 (HTLV-1) showed monoclonal growth of HTLV-1 infected T-cells. While the integration pattern of HTLV-1 was polyclonal in the peripheral blood mononuclear cells, it was monoclonal in the infiltrated cells of the pleural eff


[HIV: a risk for interventional radiologists? (editorial)]
Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr. 1995 Mar;162(3):189-90. Unique Identifier : AIDSLINE MED/95234914
Gerken G
Salmon farming: occupational health in a new rural industry.
Occup Med (Oxf). 1995 Apr;45(2):89-92. Unique Identifier : AIDSLINE MED/95234973
Douglas JD; Tweedale Medical Practice, Fort William, UK.
The medical hazards of salmon farming can be grouped into those related to marine safety, fish husbandry, fish-farm diving and disease treatments. The hostile water environment requires thermal protection and personal buoyancy aids as workers frequently fall in the water from boats or cages. Feedstuffs may generate re


Tuberculosis trends in eastern Europe and the former USSR.
Tuber Lung Dis. 1994 Dec;75(6):400-16. Unique Identifier : AIDSLINE MED/95234976
Raviglione MC; Rieder HL; Styblo K; Khomenko AG; Esteves K; Kochi A; Tuberculosis Programme, World Health Organization, Geneva,; Switzerland.
The aim of this paper is to assess trends in tuberculosis morbidity and mortality in the countries of Eastern Europe and the former USSR. Data on morbidity and mortality were obtained from reports of the Ministries of Health, a 1992 WHO questionnaire, national tuberculosis associations, and other sources. The quality


Tuberculous pericarditis in Tanzanian patients with and without HIV infection.
Tuber Lung Dis. 1994 Dec;75(6):429-34. Unique Identifier : AIDSLINE MED/95234979
Cegielski JP; Lwakatare J; Dukes CS; Lema LE; Lallinger GJ; Kitinya J; Reller LB; Sheriff F; Duke University Medical Center, Durham, NC 27710, USA.
SETTING: Large academic medical center in Tanzania . OBJECTIVES: To determine the etiologies and outcomes of large pericardial effusions in HIV-infected and uninfected patients. DESIGN: Prospective cohort study of patients admitted with new large pericardial effusions, confirmed e


Cerebral tuberculosis in the immunocompetent host: 8 cases observed in Switzerland.
Tuber Lung Dis. 1994 Dec;75(6):454-9. Unique Identifier : AIDSLINE MED/95234983
Labhard N; Nicod L; Zellweger JP; Policlinique Medicale Universitaire, Lausanne, Switzerland.
8 cases of cerebral tuberculosis were observed between January 1985 and June 1993 at the University Hospitals of Lausanne and Geneva, Switzerland . 5 patients were foreigners and 3 were Swiss, 2 of them alcoholics. All patients were HIV seronegative. Mycobacterium tuberculosis


Impact of the HIV epidemic on trends in tuberculosis in Abidjan, Cote d'Ivoire.
Tuber Lung Dis. 1995 Feb;76(1):11-6. Unique Identifier : AIDSLINE MED/95234987
Richards SB; St Louis ME; Nieburg P; Coulibaly IM; Coulibaly D; Abouya L; Gayle HD; De Cock KM; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333, USA.
SETTING: West African capital city with excellent, population-based notification of tuberculosis cases during a decade with a rapidly emerging HIV epidemic. OBJECTIVE: To evaluate the impact of the HIV epidemic on tuberculosis in Abidjan, Cote d Ivoire . DESIGN: Review of data


Trend of HIV infection in patients with pulmonary tuberculosis in south India.
Tuber Lung Dis. 1995 Feb;76(1):17-9. Unique Identifier : AIDSLINE MED/95234988
Solomon S; Anuradha S; Rajasekaran S; Institute of Microbiology, Madras Medical College, India.
SETTING: Tuberculosis is life threatening, transmissible and pandemic especially among millions of HIV infected persons. In developing countries like India where HIV infection is becoming prevalent and where tuberculosis infection has long been endemic, its incidence is increasing.


Dysregulation of homeostasis of blood T-lymphocyte subpopulations persists in chronic multibacillary pulmonary tuberculosis patients refractory to treatment.
Tuber Lung Dis. 1995 Feb;76(1):59-64. Unique Identifier : AIDSLINE MED/95234997
Bose M; Gupta A; Banavalikar JN; Saha K; Vallabhbhai Patel Chest Institute, University of Delhi, India.
DESIGN: The dysregulation of homeostasis of blood-T lymphocyte subpopulations was studied in 21 cases of chronic, multibacillary pulmonary tuberculosis refractory to treatment. The clinico-bacteriological and immunological parameters studied in these cases (Gr A) were compared with those of a group of 10 newly-diagnos


Acute eosinophilic pneumonia in a patient infected with the human immunodeficiency virus.
Tuber Lung Dis. 1995 Feb;76(1):77-9. Unique Identifier : AIDSLINE MED/95235000
Mayo J; Collazos J; Martinez E; Diaz F; Section of Infectious Diseases, Hospital de Galdakao, Vizcaya,; Spain.
A 24-year-old man infected with the human immunodeficiency virus (HIV) developed cough and progressive dyspnea over a period of 4 weeks. Absolute blood eosinophil count was 3360/mm3. Chest X-ray revealed alveolointerstitial infiltrates in both lower lobes. Eosinophilia was also found in bronchoalveolar lavage fluid. T


Localization of the inducible enhancer in the mouse interleukin-5 gene that is responsive to T-cell receptor stimulation.
Blood. 1995 Apr 15;85(8):2069-77. Unique Identifier : AIDSLINE GENBANK
Bourke PF; van Leeuwen BH; Campbell HD; Young IG; Division of Biochemistry and Molecular Biology, John Curtin; School of Medical Research, Australian National University,; Canberra.
Transcriptional regulation of the interleukin-5 (IL-5) gene in T lymphocytes appears to be of central importance in the control of the eosinophilia characteristic of allergic responses and certain parasite infections. Previous studies of IL-5 gene regulation have been hampered by the lack of a transfection assay, whic


Blood transfusions and immunophenotypic alterations of lymphocyte subsets in sickle cell anemia. The Transfusion Safety Study Group.
Blood. 1995 Apr 15;85(8):2091-7. Unique Identifier : AIDSLINE MED/95235032
Wong WY; Powars DR; Operskalski EA; Hassett J; Parker JW; Sarnaik S; Pegelow CH; Hilgartner MW; Johnson CS; Zhou Y; et al; Department of Pediatrics, University of Southern California; School of Medicine, Los Angeles 90032, USA.
Transfusions purportedly induce dysfunction of cell-mediated immunity in sickle cell anemia (SCA). We studied hematologic and lymphocytic indices in 173 human immunodeficiency virus (HIV)-negative subjects with SCA and 131 black controls. Children aged 1 to 7 years with SCA had leukocyte counts and percentages of gran


Engrafted maternal T cells in a severe combined immunodeficiency patient express T-cell receptor variable beta segments characterized by a restricted V-D-J junctional diversity.
Blood. 1995 Apr 15;85(8):2105-13. Unique Identifier : AIDSLINE MED/95235034
Sottini A; Quiros-Roldan E; Notarangelo LD; Malagoli A; Primi D; Imberti L; Consorzio per le Biotecnologie, Terzo Laboratorio Analisi,; Servizio di Immunologia Clinica, Spedali Civili, Brescia, Italy.
To better understand the peculiar functional behavior of engrafted maternal T cells in a severe combined immunodeficiency (SCID) patient, we characterized, at the molecular level, the T-cell repertoire of a SCID child with a high number of engrafted, mature, activated lymphocytes. We found that, although these transpl


Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication.
Blood. 1995 Apr 15;85(8):2114-23. Unique Identifier : AIDSLINE MED/95235035
Foli A; Saville MW; Baseler MW; Yarchoan R; Medicine Branch, National Cancer Institute, National Institutes; of Health, Bethesda, MD 20892, USA.
The cytokines interleukin-12 (IL-12) and IL-4 play important roles in the development of Th1-like (type-1) and Th2-like (type-2) T-cell responses, respectively, and there is evidence that type-1/type-2 T helper imbalances are important in the pathogenesis of human immunodeficiency virus (HIV) disease. With this backgr


Detection of Cryptococcus neoformans in bronchial lavage cytology: report of four cases.
Intern Med. 1995 Jan;34(1):54-7. Unique Identifier : AIDSLINE MED/95235152
Maesaki S; Kohno S; Mashimoto H; Araki J; Asai S; Hara K; Sasebo General Hospital.
Four cases of pulmonary cryptococcosis were diagnosed by cytological detection of Cryptococcus neoformans in bronchial lavage. Three patients had underlying diseases, but not HIV infection. The chest X-rays showed 2 patients with nodular lesions and 2 with cavitary lesions. The cryptococcal antigen in the serum was po


[Secondary prevention of sexually transmissible diseases in public health service--analysis of initial experiences in a Bremen counselling office of the chief public health office]
Gesundheitswesen. 1995 Feb;57(2):86-91. Unique Identifier : AIDSLINE MED/95235221
Jager H; Deutscher Entwicklungsdienst, Fachreferat Gesundheit, Berlin.
Medical activities of the Public Health STD programme in Bremen were analysed during a period of one year. This experimental project comprises various activities on primary prevention, counselling services, including streetwork, on social and health issues related to sexual health and confidential, anonymous diagnosis


[Clinical study on repeated infantile respiratory tract infection treated by kanggan zhibao oral liquor]
Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 Oct;14(10):586-8. Unique Identifier : AIDSLINE MED/95235261
Ma R; Zhang XL; Tian J; First Affiliated Hospital, Tianjin College, TCM.
The clinical observation of repeated infantile respiratory tract infection treated by Kanggan Zhibao (KGZB) oral liquor and controlled with levomisole was studied. The results showed that the total effective rate of KGZB was 93.2%, which was significantly more effective than that of the control group (P


[Immunological observation on chyluric patients with heat-clearing and hemostatic drugs]
Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 Oct;14(10):601-3. Unique Identifier : AIDSLINE MED/95235266
Xing C; Xing XM; Xing L; Jining Infectious Diseases Hospital, Shandong.
In order to investigate the pathogenesis and therapeutic mechanism of chyluria, an experiment with a basic Heat-clearing and hemostatic prescription was conducted in treating 30 patients of chyluria. The result, 26 cases were cured completely. The cell-mediated and humoral immunity observation showed that OKT3 and OKT


Overview of toxicological data on rifabutin.
Exp Toxicol Pathol. 1995 Jan;47(1):1-9. Unique Identifier : AIDSLINE MED/95235288
Brughera M; Scampini G; Newman AJ; Castellino S; Sammartini U; Mazue G; Pharmacia Farmitalia Carlo Erba, R & D/Toxicology Dpt., Nerviano; (Milano), Italy.
Rifabutin is a wide spectrum antibiotic particularly active on atypical and rifampicin-resistant mycobacteria. Rifabutin is more potent than rifampicin on Mycobacterium tuberculosis in vitro. Its mode of action is characterized by a high intracellular penetration in treated individuals. Clinical trials have proven the


Adhesion molecules in the nickel allergic reaction.
Int Arch Allergy Immunol. 1995 Apr;106(4):345-50. Unique Identifier : AIDSLINE MED/95235337
Silvennoinen-Kassinen S; Vainio O; Karvonen J; Kauppinen M; Kallioinen M; Department of Medical Microbiology, University of Turku, Finland.
Nickel is the major cause of allergic contact dermatitis, and to increase our understanding of this immune reaction we studied changes in the expression of adhesion molecules on mononuclear cells during nickel stimulation in vivo and in vitro. Nickel-induced lymphocyte cultures were used in vitro, the cells being exam


Anti-CD4 activity in circulating immune complexes in HIV-infected patients.
Int Arch Allergy Immunol. 1995 Apr;106(4):366-71. Unique Identifier : AIDSLINE MED/95235340
Feijoo E; Subira D; Fernandez-Guerrero M; Garcia R; Ortiz F; Department of Immunology, Fundacion Jimenez Diaz, Madrid,; Spain.
Levels of circulating immune complexes (CIC) measured by precipitation with 1.04 M ammonium sulfate ranged from 22 to 2,040 micrograms/ml in a group of 141 HIV-infected patients. CIC were elevated (> 200 micrograms/ml) in 72.2% of infected individuals. When analyzed for their HIV antigen composition, those CIC contain


Italy's patients with AIDS revolt [news]
BMJ. 1995 Apr 8;310(6984):893. Unique Identifier : AIDSLINE MED/95235366
Endean C
Differences in progression of HIV infection between men and women [letter; comment]
BMJ. 1995 Apr 8;310(6984):941. Unique Identifier : AIDSLINE MED/95235407
Egger M; Twisselmann W; Ledergerber B
Heart muscle disease related to HIV infection [letter; comment]
BMJ. 1995 Apr 8;310(6984):941-2. Unique Identifier : AIDSLINE MED/95235408
Kelleher P; Sweeney J; Anderson J
Epstein-Barr virus-associated non-Hodgkin's lymphoma in HIV-infected patients.
Leuk Lymphoma. 1995 Jan;16(3-4):217-21. Unique Identifier : AIDSLINE MED/95235430
Hernandez AM; Shibata D; Department of Pathology, University of Southern California,; School of Medicine, Los Angeles, USA.
Epstein-Barr virus (EBV) has been implicated in the pathogenesis of many lymphoproliferations arising in diverse settings, including HIV-infection. The precise roles of EBV may differ between these settings. For example, both the frequencies of EBV-association and the specific c-MYC translocations differ between spora


HIV-associated lymphoma of the gastrointestinal tract: the University of Toronto AIDS-Lymphoma Study Group experience.
Leuk Lymphoma. 1995 Jan;16(3-4):343-9. Unique Identifier : AIDSLINE MED/95235444
Imrie KR; Sawka CA; Kutas G; Brandwein J; Warner E; Burkes R; Quirt I; McGeer A; Shepherd FA; Department of Medicine, Toronto Hospital, Ontario, Canada.
We present a retrospective analysis of 31 (30 male) patients with HIV-associated gastrointestinal lymphoma which was undertaken to determine the natural history and response to therapy. Only seven patients had stage I or II lymphoma and 22 had stage IV. Pathology included diffuse large cell (13), immunoblastic (10), a


Lysis of uninfected HIV-1 gp120-coated peripheral blood-derived T lymphocytes by monocyte-mediated antibody-dependent cellular cytotoxicity.
FEMS Immunol Med Microbiol. 1995 Jan;10(2):83-91. Unique Identifier : AIDSLINE MED/95235494
Hober D; Jewett A; Bonavida B; Department of Microbiology and Immunology, UCLA School of; Medicine, University of California 90024, USA.
Previous reports from our laboratory have demonstrated that peripheral blood monocytes (PBM) from HIV-1 infected individuals are de novo activated and are cytotoxic in vitro. Significant monocyte-antibody-dependent cellular cytotoxicity (ADCC) was obtained against HIV-1 inactivated CD4+ CEM target cells coated with HI


[Pseudo-tumoral cystitis due to Toxoplasma in an patient with AIDS]
Prog Urol. 1995 Apr;5(2):270-3. Unique Identifier : AIDSLINE MED/95235597
Bron J; Haab F; Welker Y; Attal P; Benali A; Frija J; Teillac P; Le Duc A; Service d'Urologie, Hopital Saint-Louis, Paris.
The authors report a case of cystitis due to Toxoplasma Gondii infection in a patient suffering from AIDS. Initial symptoms consisted of dysuria, extreme frequency and urgent micturition responsible for pseudo urinary incontinence. Urine culture was sterile. Pelvic computed tomography and pelvic MRI demonstrated thick


[Immune status of adult population of the Bryansk region living in territory polluted by radionuclides]
Radiats Biol Radioecol. 1995 Jan-Feb;35(1):83-95. Unique Identifier : AIDSLINE MED/95235737
Oradovskaia IV; Fadeeva ID; Ul'ianova NV; Nikonova MF; Litvina MM; Lavdovskaia MV; Chernetsova LF; Khoroshilova NV
Clinical and immunological investigation with immune status evaluation of three groups of adult population of Bryansk Region was performed. The first group included 165 persons living in Vyshkov (settlement of town type in Bryansk Region) contaminated with radionuclides as a result of Chernobyl accident. The second gr


Determination of L-735 524, an human immunodeficiency virus protease inhibitor, in human plasma and urine via high-performance liquid chromatography with column switching.
J Chromatogr A. 1995 Feb 10;692(1-2):45-52. Unique Identifier : AIDSLINE MED/95235759
Woolf E; Au T; Haddix H; Matuszewski B; Merck Research Laboratories, Department of Drug Metabolism, West; Point, PA 19486.
A method for the determination of an HIV protease inhibitor, L-735 524, in human plasma and urine is described. Isolation of the analyte and the internal standard from the matrices was achieved via multiple liquid-liquid extractions with methyl tert.-butyl ether. The analyte lacks significant UV absorption at waveleng


The battle against ignorance [editorial]
Nurs Spectr (Wash D C). 1995 Apr 17;5(8):3. Unique Identifier : AIDSLINE MED/95235793
Pauly-O'Neill S
Tapping into community resources to confront the AIDS challenge.
Nurs Spectr (Wash D C). 1995 Apr 17;5(8):6-8. Unique Identifier : AIDSLINE MED/95235795
Johnson S
Inova's HIV clinical training/mentor program.
Nurs Spectr (Wash D C). 1995 Apr 17;5(8):9. Unique Identifier : AIDSLINE MED/95235796
Mackey J
In defeat of the odds [editorial]
Palliat Med. 1995 Jan;9(1):61-2. Unique Identifier : AIDSLINE MED/95235824
Cook LD
Computer-based screening of patients with HIV/AIDS for clinical-trial eligibility.
Online J Curr Clin Trials. 1995 Mar 28;Doc No 179:[3347 words; 32 paragraphs]. Unique Identifier : AIDSLINE MED/95235872
Carlson RW; Tu SW; Lane NM; Lai TL; Kemper CA; Musen MA; Shortliffe EH; Division of Medical Oncology, Stanford University Medical Center,; Palo Alto, CA 94304, USA.
OBJECTIVE: To assess the potential effect of a computer-based system on accrual to clinical trials, we have developed methodology to identify retrospectively and prospectively patients who are eligible or potentially eligible for protocols. DESIGN: Retrospective chart abstraction with computer screening of data for po


The epidemiology of HIV in India.
Trends Microbiol. 1995 Jan;3(1):17-21. Unique Identifier : AIDSLINE MED/95235949
Dietrich U; Maniar JK; Rubsamen-Waigmann H; Georg-Speyer-Haus, Frankfurt, Germany.
India is the first country outside Africa where an HIV-2 epidemic is running in parallel to an HIV-1 epidemic, resulting in a significant proportion of double infections. HIV is spreading rapidly, mainly by heterosexual contact, but also among intravenous drug users. Genetic analyse


Recombinant cytokines for controlling mycobacterial infections.
Trends Microbiol. 1995 Jan;3(1):22-7. Unique Identifier : AIDSLINE MED/95235950
Bermudez LE; Kaplan G; Kuzell Institute for Arthritis and Infectious Diseases,; California Pacific Medical Center Research Institute, San; Francisco 94115-1896, USA.
Knowing how mycobacteria exploit host cytokines to survive and which cytokines have important roles in host defense against mycobacteria should allow the use of these molecules in the treatment of mycobacterial infections. Both interleukin 2 and interferon gamma have been used to treat patients with leprosy, and granu


Bilateral red eyes in a patient infected with human immunodeficiency virus [clinical conference]
Ann Allergy Asthma Immunol. 1995 Apr;74(4):289-93. Unique Identifier : AIDSLINE MED/95236236
Bielory L; Sohn T; Rescigno R; Department of Medicine, UMD-New Jersey Medical School, Newark,; USA.
Comparison of CD4 cell count by a simple enzyme-linked immunosorbent assay using the TRAx CD4 test kit and by flow cytometry and hematology.
Clin Diagn Lab Immunol. 1995 Jan;2(1):104-14. Unique Identifier : AIDSLINE MED/95236252
Paxton H; Pins M; Denton G; McGonigle AD; Meisner PS; Phair JP; Department of Flow Cytometry, Maryland Medical Metpath,; Baltimore.
Measurement of CD4 T-lymphocyte levels is clinically useful in monitoring immune status in a number of conditions, including human immunodeficiency virus (HIV) infection, in which the absolute CD4 count is used to guide therapy. The absolute CD4 count is obtained by multiplying the results of the leukocyte count and t


Elevated levels of circulating tumor necrosis factor alpha in human immunodeficiency virus type 1-infected Africans living in Sweden.
Clin Diagn Lab Immunol. 1995 Jan;2(1):118-9. Unique Identifier : AIDSLINE MED/95236254
Sonnerborg A; Ayehunie S; Julander I; Division of Clinical Virology Institutet, Huddinge University; Hospital, Sweden.
Elevated levels of tumor necrosis factor alpha in serum were found in human immunodeficiency virus type 1 (HIV-1)-infected Africans to a higher extent than in matched HIV-1-infected Caucasians, both groups living in Sweden . The results suggest that factors not related to the enviro


A simple method for the propagation of cervical lymphocytes.
Clin Diagn Lab Immunol. 1995 Jan;2(1):40-3. Unique Identifier : AIDSLINE MED/95236262
Moscicki AB; Hunter SD; Garland S; Quinn M; Crowe SM; Shortman K; Stites D; Department of Pediatrics, University of California, San; Francisco.
Local immune function is most likely a key influence in the establishment of human papillomavirus infections and its subsequent disease. Unfortunately, little information is known about local cervical immunity, and even less is known about human papillomavirus immunoreactivity. In addition, studies of local immunoreac


Dilution assessment of cervicovaginal secretions obtained by vaginal washing for immunological assays.
Clin Diagn Lab Immunol. 1995 Jan;2(1):57-61. Unique Identifier : AIDSLINE MED/95236265
Belec L; Meillet D; Levy M; Georges A; Tevi-Benissan C; Pillot J; Unite d'Immunologie Microbienne, Institut Pasteur, Paris,; France.
Local immunological defense mechanisms in the cervicovaginal mucosa currently remain incompletely defined, especially from a quantitative point of view. Addition of an inert substance, lithium chloride (LiCl), into the washing buffer used to carry out the vaginal washing for collecting cervicovaginal secretions and me


Changes in CD45 isoform expression vary according to the duration of T-cell memory after vaccination.
Clin Diagn Lab Immunol. 1995 Jan;2(1):73-81. Unique Identifier : AIDSLINE MED/95236268
McElhaney JE; Pinkoski MJ; Meneilly GS; Department of Medicine, University of Alberta, Edmonton, Canada.
Healthy young (


Sensitivity of immune complex-dissociated p24 antigen testing for early detection of human immunodeficiency virus in infants.
Clin Diagn Lab Immunol. 1995 Jan;2(1):87-90. Unique Identifier : AIDSLINE MED/95236270
Lewis DE; Adu-Oppong A; Hollinger FB; Rosenblatt HM; Hanson IC; Reuben JM; Kline MW; Kozinetz CA; Shearer WT; Department of Microbiology, Baylor College of Medicine, Houston,; Texas 77030.
Several investigators have suggested that early diagnosis of human immunodeficiency virus (HIV) infection in infants could be accomplished with a modified, more-sensitive, acid-dissociated p24 antigen enzyme-linked immunosorbent assay (ELISA) technique (p24 antigen immune complex dissociation [ICD]). We compared detec


Enhancement of natural killer cell activity in human immunodeficiency virus-infected subjects by in vitro treatment with biologic response modifier OK-432.
Clin Diagn Lab Immunol. 1995 Jan;2(1):91-7. Unique Identifier : AIDSLINE MED/95236271
Huang XL; Fan Z; Murayama T; Rinaldo C; Department of Infectious Diseases and Microbiology, University of; Pittsburgh Graduate School of Public Health, Pennsylvania.
A decrease in natural killer (NK) cell function has been related to the progression of human immunodeficiency virus (HIV) infection. In the present study, we assessed the ability of a streptococcus-derived biologic response modifier, OK-432, to augment NK lysis of uninfected K562 and U937 cells and HIV-infected U937 c


Design of a genetic immunotoxin to eliminate toxin immunogenicity.
Gene Ther. 1995 Mar;2(2):116-23. Unique Identifier : AIDSLINE MED/95236280
Chen SY; Zani C; Khouri Y; Marasco WA; Department of Pathology, Dana-Farber Cancer Institute, Harvard; Medical School, Boston, MA 02115.
Host antibody response to toxin molecules is a major obstacle to the use of immunotoxins as efficacious agents in the treatment of human cancer and other diseases. In this study, a genetic form of immunotoxin has been designed which should eliminate toxin immunogenicity by replacing the toxin protein moiety with weakl


TCR alpha-CD3 delta epsilon association is the initial step in alpha beta dimer formation in murine T cells and is limiting in immature CD4+ CD8+ thymocytes.
Immunity. 1995 Apr;2(4):391-9. Unique Identifier : AIDSLINE MED/95236299
Kearse KP; Roberts JL; Singer A; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.
The present study has examined the molecular events leading to formation of alpha beta dimers in normal murine thymocytes and mature T cells. We demonstrate that TCR assembly proceeds by initial association of TCR alpha with CD3 delta epsilon proteins and by association of TCR beta with CD3 gamma epsilon proteins to f


Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.
Immunity. 1995 Apr;2(4):413-25. Unique Identifier : AIDSLINE MED/95236301
Suzuki H; Punt JA; Granger LG; Singer A; Experimental Immunology Branch, National Cancer Institute,; Bethesda, Maryland 20892, USA.
Differentiation of immature CD4+ CD8+ thymocytes into mature CD4+ CD8- and CD4-CD8+ T cells requires that synthesis of one or the other coreceptor molecule be terminated, a process referred to as lineage commitment. The present study has utilized a novel coreceptor reexpression assay to identify lineage commitment in


Studies on in vivo induction of HIV-1 envelope-specific cytotoxic T lymphocytes by synthetic peptides from the V3 loop region of HIV-1 IIIB gp 120.
Cell Immunol. 1995 Feb;160(2):217-23. Unique Identifier : AIDSLINE MED/95236465
Nehete PN; Casement KS; Arlinghaus RB; Sastry KJ; Department of Molecular Pathology, University of Texas M.D.; Anderson Cancer Center, Houston 77030, USA.
We have previously reported the induction of MHC class I-restricted, CD8+ cytotoxic T lymphocytes (CTLs) specific to human immunodeficiency virus type 1 (HIV-1) in mice by a 15-amino acid peptide (R15K) from the V3 loop in gp120. We now present evidence showing that CTL activity induced by R15K was stable for 8-10 wee


IL-4-based helper activity of CD4+ T cells is radiation sensitive.
Cell Immunol. 1995 Feb;160(2):248-56. Unique Identifier : AIDSLINE MED/95236469
DeKruyff RH; Fang Y; Umetsu DT; Department of Pediatrics, Stanford University, California 94305,; USA.
The capacity of CD4+ T cells to induce IgG synthesis in B cells has been known to be radioresistant for more than 20 years. However, the radiation sensitivity of helper T cells with regard to their ability to induce the synthesis of isotypes other than IgG has not been studied. We therefore irradiated KLH-primed lymph


Systemic treatment with interleukin-4 induces regression of pulmonary metastases in a murine renal cell carcinoma model.
Cell Immunol. 1995 Feb;160(2):257-63. Unique Identifier : AIDSLINE MED/95236470
Hillman GG; Younes E; Visscher D; Ali E; Lam JS; Montecillo E; Pontes JE; Haas GP; Puri RK; Department of Urology, Wayne State University School of Medicine,; Detroit, Michigan 48201, USA.
Advanced metastatic renal cell carcinoma has been shown to be responsive to immunotherapy but the response rate is still limited. We have investigated the therapeutic potential of systemic interleukin-4 (IL-4) administration for the treatment of pulmonary metastases in the murine Renca renal adenocarcinoma model. Renc


Modulation of IL-4 production in murine spleen cells by prostaglandins.
Cell Immunol. 1995 Feb;160(2):278-85. Unique Identifier : AIDSLINE MED/95236473
Parker CW; Huber MG; Godt SM; Department of Internal Medicine, Washington University School of; Medicine, St. Louis, Missouri 63110, USA.
Recently, it has been reported that IL-4 production by murine Th2 cell lines is insensitive to inhibition by E-type prostaglandins. In the present study, IL-4 production in vitro by freshly isolated concanavalin A (Con A)-stimulated murine spleen cells was readily suppressed by PGE2 with an I50 of 2 nM. Comparable sup


Diffuse Tl-201 uptake in the lungs. Etiologic classification and pattern recognition.
Clin Nucl Med. 1995 Feb;20(2):164-72. Unique Identifier : AIDSLINE MED/95236714
Abdel-Dayem H; Bag R; Macapinlac H; Elgazzar AH; Habbab N; Pescatore F; Kempf J; Department of Radiology, St. Vincent's Hospital and Medical; Center of New York,Valhalla, USA.
Diffuse Tl-201 uptake in the lungs could be because of cardiac, neoplastic, inflammatory, or interstitial lung disease. Examples from the different categories, differential diagnosis, and different patterns are presented. The authors discuss the different mechanisms of increased Tl-201 uptake in the lungs which vary a


Adolescents and AIDS prevention. The pediatrician's role [see comments]
Clin Pediatr (Phila). 1995 Jan;34(1):41-5. Unique Identifier : AIDSLINE MED/95236732
Post SG; Botkin JR; Center for Biomedical Ethics, School of Medicine, Case Western; Reserve University, Cleveland, OH 44106, USA.
Preventing AIDS in teenagers in the 1990s [editorial; comment]
Clin Pediatr (Phila). 1995 Jan;34(1):46-7. Unique Identifier : AIDSLINE MED/95236733
McGrath JW; Strasburger VC
Pharmacokinetics and organ clearance of a 3'-biotinylated, internally [32P]-labeled phosphodiester oligodeoxynucleotide coupled to a neutral avidin/monoclonal antibody conjugate.
Drug Metab Dispos. 1995 Jan;23(1):55-9. Unique Identifier : AIDSLINE MED/95236949
Kang YS; Boado RJ; Pardridge WM; Department of Medicine, UCLA School of Medicine 90024.
The pharmacokinetics and organ uptake of a 3 -biotinylated, [32P] internally labeled 36-mer phosphodiester oligodeoxynucleotide (PO-ODN) were measured after intravenous injection in the anesthetized adult rat. The PO-ODN was antisense to the tat gene of the human immunodeficiency virus, and was 3 -biotinylated to a) p


gp120, an HIV-1 protein, increases susceptibility to hypoglycemic and ischemic brain injury in perinatal rats.
Exp Neurol. 1995 Mar;132(1):123-33. Unique Identifier : AIDSLINE MED/95237325
Barks JD; Sun R; Malinak C; Silverstein FS; Department of Pediatrics, University of Michigan, Ann Arbor, USA.
Recent data suggest that gp120, a glycoprotein secreted by HIV-1-infected macrophages, is neurotoxic, and that toxicity is mediated, at least in part, by overactivation of NMDA-type excitatory amino acid receptors. In experimental animals, considerable evidence indicates that hypoglycemic and ischemic neuronal injury


A longitudinal comparison of the AIDS-related attitudes and knowledge of parents and their children.
Fam Plann Perspect. 1995 Jan-Feb;27(1):4-10, 17. Unique Identifier : AIDSLINE MED/95237358
Levy SR; Weeks K; Handler A; Perhats C; Franck JA; Hedeker D; Zhu C; Flay BR; Prevention Research Center, University of Illinois at Chicago.
As part of an evaluation of an experimental school-based AIDS risk-reduction program, data from 2,392 middle-school students in 15 high-risk school districts and from 1,627 of their parents were compared to examine how young adolescents and their parents differ with respect to AIDs-related knowledge and attitudes. At


Liposome destabilization induced by the HIV-1 fusion peptide effect of a single amino acid substitution.
FEBS Lett. 1995 Apr 3;362(2):243-6. Unique Identifier : AIDSLINE MED/95237389
Pereira FB; Goni FM; Nieva JL; Department of Biochemistry and Molecular Biology, University of; the Basque Country, Bilbao, Spain.
The 23-residue synthetic peptide representing the N-terminus of HIV-1 gp41 is known to induce either leakage or fusion of lipid vesicles depending on the experimental conditions. In this paper we report that a polar amino acid substitution V-->E at position 2, known to block gp41 activity in vivo, makes the peptide un


[Efficacy of thalidomide in the treatment of esophageal ulcers in human immunodeficiency virus infection (letter)]
Gastroenterol Clin Biol. 1995 Jan;19(1):128-9. Unique Identifier : AIDSLINE MED/95237489
Sire S; Fraisse P; Rey D; Jacquemin C; Kempf G; Partisani M; Lang JM
HIV prevalence and risk behaviour among prostitutes and clients in Amsterdam: migrants at increased risk for HIV infection.
Genitourin Med. 1993 Aug;69(4):251-6. Unique Identifier : AIDSLINE MED/95237824
van Haastrecht HJ; Fennema JS; Coutinho RA; van der Helm TC; Kint JA; van den Hoek JA; Municipal Health Service, Department of Public Health and; Environment Amsterdam, the Netherlands.
OBJECTIVES--To study groups of prostitutes and clients of prostitutes in order (i) to determine HIV prevalence and sexual risk behaviour, (ii) to determine differences between samples recruited within and outside a clinic for sexually transmitted diseases (STD) and (iii) to determine correlates of inconsistent condom


Detection of varicella-zoster virus DNA using the polymerase chain reaction in an immunocompromised patient with transverse myelitis secondary to herpes zoster.
Genitourin Med. 1993 Aug;69(4):273-5. Unique Identifier : AIDSLINE MED/95237829
Grant AD; Fox JD; Brink NS; Miller RF; Department of Medicine, University College and Middlesex School; of Medicine, London, UK.
A case of herpes zoster transverse myelitis is described in which the clinical diagnosis was confirmed by demonstrating the presence of varicella-zoster virus (VZV) DNA in the cerebrospinal fluid (CSF) by amplification using the polymerase chain reaction. This case illustrates the potential role of the selective ampli


Neisseria gonorrhoeae isolated at St. Mary's Hospital London, 1980-91.
Genitourin Med. 1993 Aug;69(4):286-9. Unique Identifier : AIDSLINE MED/95237832
Renton AM; Ison CA; Whitaker L; Kirtland K; Kupek E; Harris JR; Academic Department of Public Health, St. Mary's Hospital Medical; School, London, UK.
OBJECTIVE--To describe and discuss the trends in the isolation of Neisseria gonorrhoeae from patients attending the Genitourinary Medicine Clinic at St. Mary s Hospital, Paddington, London between 1980 and 1991. DESIGN--A retrospective study of the total number of gonococci isolated over an eleven year period was perf


Soap and water prophylaxis for limiting genital ulcer disease and HIV-1 infection in men in sub-Saharan Africa.
Genitourin Med. 1993 Aug;69(4):297-300. Unique Identifier : AIDSLINE MED/95237835
O'Farrell N; Department of Genito-urinary Medicine, Guy's Hospitals, London,; UK.
In general, East, Central and Southern Africa appear to be worse affected by HIV-1 infection than West Africa. So far there is little evidence to suggest that differences in either sexual behaviour or numbers of sexual partners could account for this disparity. Two risk factors in men for acquiring HIV-1, that tend to


Tissue erosion with perianal warts in HIV infection.
Genitourin Med. 1993 Aug;69(4):312-3. Unique Identifier : AIDSLINE MED/95237838
Nathan M; Beck S; Department of Genitourinary Medicine, Doncaster Royal Infirmary,; UK.
A case of painful tissue erosion due to perianal warts is described with HIV infection. Such a development can be avoided by frequent and careful monitoring.


Risk for hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections among prostitutes [letter]
Genitourin Med. 1993 Aug;69(4):321-2. Unique Identifier : AIDSLINE MED/95237840
Echevarria S; San Miguel G; Pelayo T; Salas C; Casafont F; Crespo F; Pons Romero F
Staphylococcus aureus pericarditis in a patient with AIDS [letter]
Genitourin Med. 1993 Aug;69(4):324-5. Unique Identifier : AIDSLINE MED/95237844
Grant A; Pitkin AD; Buscombe JR; Corcoran GD; Miller RF
Fournier's gangrene and HIV disease [letter]
Genitourin Med. 1993 Aug;69(4):326. Unique Identifier : AIDSLINE MED/95237845
Murphy M; Mulcahy F
Prevent AIDS [letter; comment]
Image J Nurs Sch. 1995 Spring;27(1):4. Unique Identifier : AIDSLINE MED/95237852
Girardin BW
Women and AIDS [letter; comment]
Image J Nurs Sch. 1995 Spring;27(1):4. Unique Identifier : AIDSLINE MED/95237853
Doonan S
Disparity in the percentage of CD4+ T lymphocytes and prognosis of HIV-infected intravenous drug users in Malaysia.
Immunol Lett. 1994 Dec;43(3):177-82. Unique Identifier : AIDSLINE MED/95237873
Norazmi MN; Suarn S; Department of Immunology, School of Medical Sciences, Universiti; Sains Malaysia, Kelantan.
The CD4+ T-lymphocyte absolute count (CD4ac), CD4+ T-lymphocyte percentage (CD4%) and total lymphocyte count (Loac) were assessed in HIV-seropositive intravenous drug users (IVDU) with reference to their correlation with the clinical categories A, B, and C as stipulated by the Centre of Disease Control and Prevention,


Molecular characterization of a human anti-HIV 1 monoclonal antibody revealed a CD26-related motif in CDR2.
Immunol Lett. 1995 Jan;44(1):25-30. Unique Identifier : AIDSLINE MED/95237884
Chin LT; Duenas M; Levi M; Hinkula J; Wahren B; Borrebaeck CA; Department of Immunotechnology, Lund University, Sweden.
Genes encoding the immunoglobulin variable regions of a human anti-HIV-1 IgG1 kappa monoclonal antibody were rescued from a hybridoma, derived from a sero-negative donor, using PCR cloning and expression in Escherichia coli. The ELISA binding results obtained from the expressed Fab fragment confirmed the anti-V3 loop


Tumor-associated glycoantigen, sialyl Lewis(a) as a target for bispecific antibody-directed adoptive tumor immunotherapy.
Immunol Lett. 1995 Jan;44(1):35-40. Unique Identifier : AIDSLINE MED/95237886
Ohta S; Tsukamoto H; Watanabe K; Makino K; Kuge S; Hanai N; Habu S; Nishimura T; Department of Immunology, Tokai University School of Medicine,; Isehara, Japan.
The KM231 mAb recognizing sialyl Lewis(a) (sLe(a)) epitope of glycoprotein or glycolipid expressed on various human cancers was used to prepare bispecific antibody (BSAb) containing anti-CD3 x anti-sLe(a) mAb. The effect of anti-CD3 x anti-sLe(a) BSAb on the induction of cytotoxicity by activated T cells was investiga


High mortality in the Thule cohort: an unhealthy worker effect.
Int J Epidemiol. 1994 Dec;23(6):1174-8. Unique Identifier : AIDSLINE MED/95238073
Juel K; Danish Institute for Clinical Epidemiology, Copenhagen.
BACKGROUND. The objective was to study mortality in the Thule cohort in order to clarify whether it is a selected population and to ascertain the possibility of misinterpretation when national mortality rates are used as reference in the analysis of occupational mortality. METHODS. The cohort consists of 4322 Danish m


Regarding Stelzer and Griffin, IJROBP 27:1057-1061; 1993. Oncology Working Group [letter; comment]
Int J Radiat Oncol Biol Phys. 1995 Apr 30;32(1):276-7. Unique Identifier : AIDSLINE MED/95238204
Law M; Cooper S; Newell M
Evolution of endemic pemphigus foliaceus (fogo selvagem) after HIV-1 infection.
J Am Acad Dermatol. 1995 May;32(5 Pt 1):809-11. Unique Identifier : AIDSLINE MED/95238639
Cunha PR; Focaccia RR; Diaz LA; Department of Dermatology, Facultade de Medicina de Jundiai, Sao; Paulo, Brazil.
Cutaneous manifestations of disseminated cryptococcosis.
J Am Acad Dermatol. 1995 May;32(5 Pt 2):844-50. Unique Identifier : AIDSLINE MED/95238651
Dimino-Emme L; Gurevitch AW; Department of Medicine, Harbor-UCLA, Medical Center, Torrance,; USA.
Disseminated cryptococcosis is a life-threatening infection with cutaneous dissemination in 10% to 20% of cases. We describe seven patients with disseminated cryptococcosis with variable cutaneous manifestations. AIDS was a predisposing factor in six patients. Cutaneous presentations included a draining sinus tract, v


Multiple dermatofibromas in a woman with HIV infection and systemic lupus erythematosus.
J Am Acad Dermatol. 1995 May;32(5 Pt 2):901-3. Unique Identifier : AIDSLINE MED/95238665
Lu I; Cohen PR; Grossman ME; Department of Dermatology, College of Physicians and Surgeons of; Columbia University, New York, NY, USA.
Associations of multiple dermatofibromas with autoimmune disorders, altered immunity, or both have been described. We report the case of a 33-year-old black woman with HIV infection and an 11-year history of systemic lupus erythematosus in whom 15 dermatofibromas developed while she was receiving systemic corticostero


Pyoderma gangrenosum in an HIV-infected patient.
J Am Acad Dermatol. 1995 May;32(5 Pt 2):912-4. Unique Identifier : AIDSLINE MED/95238668
Clark HH; Cohen PR; Department of Dermatology, University of Texas M.D. Anderson; Cancer Center, Houston 77030, USA.
Pyoderma gangrenosum has previously been reported in four patients with HIV infection. We describe here the case of a fifth HIV-infected patient with pyoderma gangrenosum and review the characteristics of the four previously reported cases.


NIDR--a view from the inside.
J Dent Res. 1995 Feb;74(2):630-3. Unique Identifier : AIDSLINE MED/95238670
Loe H
Dentists' attitudes toward the treatment of HIV-positive patients.
J Am Dent Assoc. 1995 Apr;126(4):509-14. Unique Identifier : AIDSLINE MED/95238740
Bennett ME; Weyant RJ; Wallisch JM; Green G; University of Pittsburgh School of Dental Medicine, Department of; Dental Behavioral Science 15261, USA.
The authors studied the attitudes of 1,000 U.S. dentists toward the treatment of HIV-positive patients. Using a random-sample mail survey, they measured dentists professional attitudes toward treating HIV/AIDS patients, fear of contagion and negative emotions toward HIV-positive patients. The results indicate that 68


Elevated IgE level in relationship to nutritional status and immune parameters in early human immunodeficiency virus-1 disease.
J Allergy Clin Immunol. 1995 Apr;95(4):886-92. Unique Identifier : AIDSLINE MED/95238799
Shor-Posner G; Miguez-Burbano MJ; Lu Y; Feaster D; Fletcher M; Sauberlich H; Baum MK; Department of Epidemiology and Public Health, University of Miami; School of Medicine, FL 33101, USA.
Elevation of IgE has been associated with T-cell dysregulation and with the occurrence of opportunistic infections in patients with acquired immunodeficiency syndrome. The precise cause of IgE overproduction during the early stages of human immunodeficiency virus (HIV)-1 disease, however, has not been established. In


Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation.
J Immunol. 1995 May 1;154(9):4294-301. Unique Identifier : AIDSLINE MED/95238926
Elson LH; Nutman TB; Metcalfe DD; Prussin C; Laboratory of Parasitic Diseases, National Institute of Allergy; and Infectious Diseases, National Institutes of Health, Bethesda,; MD 20892, USA.
Using three-color flow cytometric analysis for the detection of intracellular cytokines, we have been able to determine the exact combination of cytokines produced by individual T lymphocytes. Because CD4+CD27- lymphocytes have been shown to produce more IL-4 and IL-5 than CD4+CD27+ lymphocytes, cells from normal indi


Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1.
J Immunol. 1995 May 1;154(9):4363-70. Unique Identifier : AIDSLINE MED/95238933
Lancki DW; Qian D; Fields P; Gajewski T; Fitch FW; Department of Pathology, University of Chicago, IL 60637, USA.
The protein tyrosine kinase Fyn has been shown to be involved in signal transduction through the TCR and the glycosyl-phosphatidylinositol-linked surface molecule Thy-1 expressed on T cells. In this study, we examine the requirement for Fyn expression in signaling through the TCR or Thy-1 using a panel of Ag-specific


V7, a novel leukocyte surface protein that participates in T cell activation. I. Tissue distribution and functional studies.
J Immunol. 1995 May 1;154(9):4423-33. Unique Identifier : AIDSLINE MED/95238940
Rivas A; Ruegg CL; Zeitung J; Laus R; Warnke R; Benike C; Engleman EG; Department of Pathology, Stanford University School of Medicine,; CA 94305, USA.
Among a panel of mouse mAbs generated to a human T cell clone, one mAb, V7.1, inhibited T cell activation in the mixed lymphocyte reaction and was studied further. V7.1 reacted strongly with Ag-specific T cell clones, in addition to freshly isolated monocytes and granulocytes. However, the mAb reacted weakly with fres


IL-12 enhances Th1-type responses in human Leishmania donovani infections.
J Immunol. 1995 May 1;154(9):4623-9. Unique Identifier : AIDSLINE MED/95238960
Ghalib HW; Whittle JA; Kubin M; Hashim FA; el-Hassan AM; Grabstein KH; Trinchieri G; Reed SG; Department of Microbiology, College of Medicine, University of; Juba, Khartoum, Sudan.
IL-12 is a pluripotent cytokine that interacts with NK and T cells to play a central role in the initiation and maintenance of Th1 responses and IFN-gamma production. Because of the interactive relationship between IL-12 and IFN-gamma response to infectious organisms, a study was undertaken to examine the role of IL-1


CD8 T lymphocytes specific for the secreted p60 antigen protect against Listeria monocytogenes infection.
J Immunol. 1995 May 1;154(9):4642-50. Unique Identifier : AIDSLINE MED/95238962
Harty JT; Pamer EG; Department of Microbiology, College of Medicine, University of; Iowa, Iowa City 52242, USA.
The ability of Listeria monocytogenes to gain access to the cytoplasm of infected cells results in the processing and presentation of bacterial Ags through the MHC class I pathway. As a result, CD8 T cells are the most effective mediators of acquired immunity in the mouse model of L. monocytogenes infection. CD8 T cel


Vaccination routes that fail to elicit protective immunity against Schistosoma mansoni induce the production of TGF-beta, which down-regulates macrophage antiparasitic activity.
J Immunol. 1995 May 1;154(9):4693-700. Unique Identifier : AIDSLINE MED/95238968
Williams ME; Caspar P; Oswald I; Sharma HK; Pankewycz O; Sher A; James SL; Immunobiology Section, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892, USA.
C57BL/6 mice immunized intradermally (i.d.) with bacillus Calmette Guerin (BCG) plus killed skin-stage schistosomula are protected against subsequent infection with Schistosoma mansoni, whereas immunization by i.v. or i.m. routes is not protective. Moreover, previous immunization via the nonprotective i.v. route inter


IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia.
J Immunol. 1995 May 1;154(9):4701-9. Unique Identifier : AIDSLINE MED/95238969
Wynn TA; Jankovic D; Hieny S; Cheever AW; Sher A; Immunology and Cell Biology Section, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892, USA.
Vaccination of mice with radiation-attenuated cercariae of Schistosoma mansoni results in a highly significant but partial protection against challenge infection. This immunity is dependent on CD4+ T cells, and because of its suppression by anti-IFN-gamma, appears to be caused by a Th1 response. Nevertheless, both Th1


Gynecological surgical outcomes among asymptomatic human immunodeficiency virus-infected women and uninfected control subjects.
J La State Med Soc. 1995 Mar;147(3):109-12. Unique Identifier : AIDSLINE MED/95239058
Devito JR; Robinson WR; Tulane University School of Medicine, Dept of Obstetrics and; Gynecology, New Orleans 70112, USA.
To determine the effect of asymptomatic human immunodeficiency virus (HIV) infection on the risk of complications and outcomes in women undergoing gynecological surgical procedures, retrospective analysis was performed of 62 asymptomatic HIV-infected women who underwent gynecological procedures. One hundred forty sero


The role of the innate immune response in Th1 cell development following Leishmania major infection.
J Leukoc Biol. 1995 Apr;57(4):515-22. Unique Identifier : AIDSLINE MED/95239064
Scharton-Kersten T; Scott P; Department of Pathobiology, University of Pennsylvania, School of; Veterinary Medicine, Philadelphia 19104, USA.
Infection of mice with the protozoan parasite Leishmania major is an established model with which to study the in vivo development of CD4+ Th cell subsets. Interferon-gamma (IFN-gamma), produced by natural killer (NK) cells (AsGM1+, CD4-, CD8-, CD3-), regulates CD4+ T cell subset development and early resistance to L.


T cells and HIV-induced T cell syncytia exhibit the same motility cycle.
J Leukoc Biol. 1995 Apr;57(4):643-50. Unique Identifier : AIDSLINE MED/95239082
Sylwester A; Shutt D; Wessels D; Stapleton JT; Stites J; Kennedy RC; Soll DR; Department of Biological Sciences, University of Iowa, Iowa City; 52242, USA.
Ameboid cells ranging in complexity from Dictyostelium amebas to human polymorphonuclear leukocytes (PMNs) translocate in a cyclical fashion. Using computer-assisted motion analysis, we have analyzed the motility of human lymphocytes of the immortal SupT1 cell line and of a peripheral blood mononuclear cell population


Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway.
J Exp Med. 1995 May 1;181(5):1623-33. Unique Identifier : AIDSLINE MED/95239105
Lucas B; Vasseur F; Penit C; Unite 345 Institut de la Sante et de la Recherche Medicale,; CHU Necker-Enfants, Paris, France.
Kinetics of mature T cell generation in the thymus of normal or major histocompatibility complex (MHC) class I- or II-deficient mice were studied by the bromodeoxyuridine pulse labeling method. As previously described, the early activation and final maturation phases were found to be synchronous for the two T cell lin


Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.
J Exp Med. 1995 May 1;181(5):1755-62. Unique Identifier : AIDSLINE MED/95239117
Jacobson NG; Szabo SJ; Weber-Nordt RM; Zhong Z; Schreiber RD; Darnell JE Jr; Murphy KM; Department of Pathology, Washington University School of; Medicine, St. Louis, Missouri 63110, USA.
Interleukin 12 (IL-12) initiates the differentiation of naive CD4+ T cells to T helper type 1 (Th1) cells critical for resistance to intracellular pathogens such as Leishmania major. To explore the basis of IL-12 action, we analyzed induction of nuclear factors in Th1 cells. IL-12 selectively induced nuclear DNA-bindi


T cell receptor repertoire in polymyositis: clonal expansion of autoaggressive CD8+ T cells.
J Exp Med. 1995 May 1;181(5):1863-8. Unique Identifier : AIDSLINE MED/95239128
Bender A; Ernst N; Iglesias A; Dornmair K; Wekerle H; Hohlfeld R; Department of Neuroimmunology, Max-Planck-Institute of; Psychiatry, Martinsried, Germany.
In polymyositis (PM), CD8+ T cell receptor (TCR) alpha/beta + cells invade and destroy major histocompatibility complex class I-positive muscle fibers. We combined polymerase chain reaction (PCR) and double-fluorescence immunocytochemistry to analyze the T cell receptor (TCR) repertoire expressed in muscle of PM patie


Absence of human retroviral antibodies in epidemic neuropathy in Cuba: report of the first two cases of HTLV-I-associated tropical spastic paraparesis observed in Cuba [letter]
J Neurol Sci. 1995 Jan;128(1):112-3. Unique Identifier : AIDSLINE MED/95239214
Estrada RA; Luis S; Mustelier R; Ruiz W; Rodriguez B; Miranda A; Roman GC
Contralateral early blink reflex in patients with HTLV-I associated myelopathy/tropical spastic paraparesis.
J Neurol Sci. 1995 Jan;128(1):51-7. Unique Identifier : AIDSLINE MED/95239220
Leon FE; Arimura K; Arimura Y; Sonoda Y; Osame M; Third Department of Internal Medicine, Kagoshima University; School of Medicine, Japan.
Thirty-two Japanese patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) were studied by means of the electrically elicited blink reflex and three responses (R1, R2, R3) were registered. 69% of the patients displayed a uni- or bilateral crossed R1 response (R1k) as compared to 11% in the c


Epidemiology of hemophilia and of HIV infection in Italy. GICC. Gruppo Italiano Coagulopatie Congenite.
J Clin Epidemiol. 1994 Nov;47(11):1297-306. Unique Identifier : AIDSLINE MED/95239253
Ghirardini A; Schinaia N; Chiarotti F; De Biasi R; Rodeghiero F; Binkin N; Istituto Superiore di Sanita', AIDS Center, Rome, Italy.
To evaluate the incidence and prevalence of hemophilia in Italy and the impact of HIV infection on the Italian hemophiliac population, data from a computerized national registry of patients from 95% of the hemophilia care centers in Italy were analyzed. A total of 4643 patients were


A novel magnetic particle agglutination in microtiter plates for rapid detection of human T-lymphotropic virus type I antibody.
J Clin Lab Anal. 1995;9(1):59-62. Unique Identifier : AIDSLINE MED/95239482
Sohma K; Kinoshita Y; Morishita S; Fujino R; Saito T; Diagnostic Research Laboratories, Fujirebio, Inc., Tokyo, Japan.
We have developed a novel magnetic particle agglutination (MPA) method for rapid detection of antibody to human T-lymphotropic virus type I (HTLV-I). This method is suitable for screening determination. The assay uses purified viral antigen coated on magnetic particles, which are novel artificial particles made of gel


Mycoses in AIDS patients.
J Med Vet Mycol. 1994;32 Suppl 1:65-77. Unique Identifier : AIDSLINE MED/95239515
Dupont B; Denning DW; Marriott D; Sugar A; Viviani MA; Sirisanthana T; Institut Pasteur, Paris, France.
Biotypes of oral Candida albicans isolates in human immunodeficiency virus-infected patients from diverse geographic locations.
J Oral Pathol Med. 1995 Jan;24(1):32-6. Unique Identifier : AIDSLINE MED/95239636
Tsang PC; Samaranayake LP; Philipsen HP; McCulloug M; Reichart PA; Schmidt-Westhausen A; Scully C; Porter SR; Oral Biology Unit, University of Kong.
Oral Candida albicans isolates from HIV-infected individuals in Hong Kong , Australia , Germany and England were characterised using a biotyping system base


Structural studies of HIV-1 Tat protein.
J Mol Biol. 1995 Apr 7;247(4):529-35. Unique Identifier : AIDSLINE PDB
Bayer P; Kraft M; Ejchart A; Westendorp M; Frank R; Rosch P; Lehrstuhl fur Biopolymere und Bayreuther Institut fur; Makromolekulforschung Universitat Bayreuth, Germany.
Tat (trans-activator) proteins are early RNA binding proteins regulating lentiviral transcription. These proteins are necessary components in the life cycle of all known lentiviruses, such as the human immunodeficiency viruses (HIV) or the equine infectious anemia virus (EIAV). Tat proteins are thus ideal targets for


Recombination in AIDS viruses.
J Mol Evol. 1995 Mar;40(3):249-59. Unique Identifier : AIDSLINE GENBANK/X15781
Robertson DL; Hahn BH; Sharp PM; Department of Genetics, University of Nottingham, Queens Medical; Centre, United Kingdom.
Recombination contributes to the generation of genetic diversity in human immunodeficiency viruses (HIV) but can only occur between viruses replicating within the same cell. Since individuals have not been found to be simultaneously coinfected with multiple divergent strains of HIV-1 or HIV-2, recombination events hav


Promising new treatments for cytomegalovirus retinitis.
JAMA. 1995 May 10;273(18):1457-9. Unique Identifier : AIDSLINE MED/95239886
Polis MA; Masur H; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, MD 20892-1880, USA.
Differing attitudes toward people who have AIDS [comment]
J Soc Psychol. 1995 Feb;135(1):105-6. Unique Identifier : AIDSLINE MED/95240041
Posson TR; Jackson TT; Department of Psychology, Fort Hays State University, KS; 67601-4099.
Comparison of health-related quality of life in clinical trial and nonclinical trial human immunodeficiency virus-infected cohorts.
Med Care. 1995 Apr;33(4 Suppl):AS15-25. Unique Identifier : AIDSLINE MED/95240182
Cunningham WE; Bozzette SA; Hays RD; Kanouse DE; Shapiro MF; Department of Medicine, School of Medicine, University of; California, Los Angeles, USA.
Clinical trials randomly assign treatments and select participants to maximize internal validity, but such selection threatens generalizability by excluding important groups with the diseases under study. Particularly in human immunodeficiency virus (HIV) disease, the results of clinical trials are applied broadly to


Change in clinical status, health status, and health utility outcomes in HIV-infected patients.
Med Care. 1995 Apr;33(4 Suppl):AS173-82. Unique Identifier : AIDSLINE MED/95240185
Revicki DA; Wu AW; Murray MI; Medical Technology Assessment Program, Battelle Centers for; Public Health Research and Evaluation, Arlington, VA 22201, USA.
Psychometric health status scales and health utility scales were compared to measure the impact of changes in clinical status in patients infected with the human immunodeficiency virus (HIV). The data used included the first two waves of a longitudinal study of 160 HIV-infected patients, a population that was 34% wome


Kaposi's sarcoma and new herpesvirus [letter]
Lancet. 1995 Apr 22;345(8956):1043. Unique Identifier : AIDSLINE MED/95240251
Collandre H; Ferris S; Grau O; Montagnier L; Blanchard A
Kaposi's-sarcoma-associated herpesvirus in HIV-negative Kaposi's sarcoma [letter]
Lancet. 1995 Apr 22;345(8956):1043-4. Unique Identifier : AIDSLINE MED/95240252
Boshoff C; Whitby D; Hatziioannou T; Fisher C; van der Walt J; Hatzakis A; Weiss R; Schulz T
HIV-1 subtype C in China [letter]
Lancet. 1995 Apr 22;345(8956):1051-2. Unique Identifier : AIDSLINE MED/95240271
Luo CC; Tian C; Hu DJ; Kai M; Dondero T; Zheng X
Transmission of oral Candida albicans strains between HIV-positive patients [letter]
Lancet. 1995 Apr 22;345(8956):1052-3. Unique Identifier : AIDSLINE MED/95240272
Boerlin P; Addo M; Boerlin-Petzold F; Durussel C; Pagani JL; Chave JP; Bille J
AIDS in Manchester, 1959? [letter; comment]
Lancet. 1995 Apr 22;345(8956):1058. Unique Identifier : AIDSLINE MED/95240282
Corbitt G; Bailey AS
Cryptosporidium and the food supply.
Lancet. 1995 May 6;345(8958):1128-9. Unique Identifier : AIDSLINE MED/95240293
Petersen C; Division of Infectious Diseases, San Francisco, General Hospital,; CA, USA.
Emergence of fluoroquinolone-resistant tuberculosis in New York City.
Lancet. 1995 May 6;345(8958):1148-50. Unique Identifier : AIDSLINE MED/95240301
Sullivan EA; Kreiswirth BN; Palumbo L; Kapur V; Musser JM; Ebrahimzadeh A; Frieden TR; New York City Department of Health, New York, USA.
22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 a


Kaposi's sarcoma and new herpesvirus [letter; comment]
Lancet. 1995 May 6;345(8958):1180. Unique Identifier : AIDSLINE MED/95240328
Lebbe C; de Cremoux P; Rybojad M; Costa da Cunha C; Morel P; Calvo F
Down-regulation of Th2 cell-mediated murine peritoneal eosinophilia by antiallergic agents.
Life Sci. 1995;56(19):1647-54. Unique Identifier : AIDSLINE MED/95240356
Yamaya H; Basaki Y; Togawa M; Kojima M; Kiniwa M; Matsuura N; Immunological Research Laboratory, Hanno Research Center, Taiho; Pharmaceutical Co. Ltd., Saitama, Japan.
Local eosinophilia has been linked to the pathogenesis of the inflammatory aspect of allergic diseases. The present study found that co-injection of D10G4.1 (D10) cells, a murine Th2 clone, with conalbumin (CA) into the peritoneal cavity of AKR/J mice increased the number of peritoneal eosinophils. The accumulation of


Guardianship and the refusal of treatment.
MCN Am J Matern Child Nurs. 1995 Mar-Apr;20(2):109. Unique Identifier : AIDSLINE MED/95240370
Rhodes AM; University of Iowa, Iowa City, USA.
AIDS among migrant farmers [news]
MCN Am J Matern Child Nurs. 1995 Mar-Apr;20(2):118. Unique Identifier : AIDSLINE MED/95240373
Free access to electronic AIDS information [news]
MCN Am J Matern Child Nurs. 1995 Mar-Apr;20(2):118. Unique Identifier : AIDSLINE MED/95240374
Zidovudine in pregnancy.
MCN Am J Matern Child Nurs. 1995 Mar-Apr;20(2):122. Unique Identifier : AIDSLINE MED/95240375
Corbett JV; Kenney C; University of San Francisco, School of Nursing, USA.
CD4+/CD8+ T-lymphocyte ratio: effects of rehydration before exercise in dehydrated men.
Med Sci Sports Exerc. 1995 Feb;27(2):194-9. Unique Identifier : AIDSLINE MED/95240415
Greenleaf JE; Jackson CG; Lawless D; Laboratory for Human Environmental Physiology, NASA, Ames; Research Center, Moffett Field, CA 94035-1000, USA.
Effects of fluid ingestion on CD4+/CD8+ T-lymphocyte cell ratios were measured in four dehydrated men (ages 30-46 yr) before and after 70 min of supine submaximal (71% VO2max) lower extremity cycle exercise. Just before exercise, Evans blue dye was injected for measurement of plasma volume. The subjects then drank one


Multiple anti-cytokine activities secreted from tanapox virus-infected cells.
Microb Pathog. 1994 Nov;17(5):347-53. Unique Identifier : AIDSLINE MED/95240435
Essani K; Chalasani S; Eversole R; Beuving L; Birmingham L; Department of Biological Sciences, Western Michigan University,; Kalamazoo 49008, USA.
Tanapox virus (TPV) produces a mild disease in humans characterized by transient fever, one or more nodular skin lesions and regional lymphadenopathy. We demonstrate that TPV-infected cells, but not mock-infected cells, secrete an early 38 kDa glycopeptide that, unlike any other known protein, binds to human (h) inter


Tumor necrosis factor receptor expression in HIV-1-infected CD4+ T cells.
Microbiol Immunol. 1994;38(12):1005-8. Unique Identifier : AIDSLINE MED/95240465
Hober D; De Groote D; Vanpouille N; Dehart I; Shen L; Wattre P; Maniez-Montreuil M; Laboratoire de Bacteriologie-Virologie B CHRU Lille, France.
We investigated whether HIV-1 can regulate tumor necrosis factor receptor (TNFR) expression in SupT-1, a CD4+ T-cell line. The cells were infected with HIV-1 containing 1,000 cpm RT activity, as early as day 3 after infection and all along the culture the supernatant level of core protein p24 was > 250 pg/ml, and on d


Alteration of immune responses of rabbits infected with bovine immunodeficiency-like virus.
Microbiol Immunol. 1994;38(12):943-50. Unique Identifier : AIDSLINE MED/95240469
Hirai N; Xuan S; Ochiai K; Onuma M; Department of Epizootiology, Faculty of Veterinary Medicine,; Hokkaido University, Japan.
Nine 3-month-old rabbits were inoculated with bovine immunodeficiency-like virus (BIV) to study the pathogenesis of BIV and alteration of the immune responses in experimentally infected rabbits. BIV proviral DNA and anti-BIV antibodies were detected from all rabbits inoculated with BIV-infected bovine embryo spleen (B


['94 oncology update]
Med Klin. 1995 Mar 1;90(3):144-59. Unique Identifier : AIDSLINE MED/95240499
Pfreundschuh M; Medizinische Klinik und Poliklinik, Innere Medizin I,; Universitat des Saarlandes, Homburg, Saar.
[Cross reactivity and amino acid structural homology of immunodominant peptide fragments of structural viruses from the human retroviruses HTLV-I, HTLV-II, HIV-1, and HIV-2]
Mol Biol (Mosk). 1995 Jan-Feb;29(1):225-38. Unique Identifier : AIDSLINE MED/95240642
Rasuli AM; Rasuli ShM; Klepikov NN; Andreev SM; Meshcheriakova DV; Tarasova SO; Seniuta NB; Syrtsev AV; Gurtsevich VE
Twelve synthetic peptides corresponding to 9 immunodominant regions of structural proteins of human retroviruses HTLV-I, HIV-1, and HIV-2 were studied in enzyme-linked immunosorbent assay for cross reactivity with heterotypical for each peptide anti-retroviral antibodies. The search of amino acid homologies was carrie


Anomaly admitted in 'first' AIDS case [news]
Nature. 1995 May 4;375(6526):4. Unique Identifier : AIDSLINE MED/95240727
Masood E
Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by a human pregnancy hormone [published erratum appears in Nature 1995 Aug 3;376(6539):447] [see comments]
Nature. 1995 May 4;375(6526):64-8. Unique Identifier : AIDSLINE MED/95240733
Lunardi-Iskandar Y; Bryant JL; Zeman RA; Lam VH; Samaniego F; Besnier JM; Hermans P; Thierry AR; Gill P; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892, USA.
Kaposi s sarcoma (KS) occurs more often in men than in women and HIV-1-associated KS has a high occurrence in homosexual men (over 30%). Most cultures of KS tumours yield cells with properties of hyperplastic (not malignant) endothelial cells under the control of several cytokines. The role of HIV-1 may be in promotin


[Feasibility of transferring medical-technological aid to the home situation for patients with cancer or a serious infection]
Ned Tijdschr Geneeskd. 1995 Apr 15;139(15):788-91. Unique Identifier : AIDSLINE MED/95240774
Witteveen PO; van Boxtel AJ; Nieuwland M; Neijt JP; Blijham GH; Academisch Ziekenhuis, afd. Interne Geneeskunde, Utrecht.
OBJECTIVE. To describe the feasibility of home care technology for patients with cancer or serious infectious diseases. SETTING. Utrecht. METHODS. One hundred and thirty one patients with cancer or serious infections were treated at home with parenteral administration of fluid, cytostatics, analgetics, blood products


[HIV infection in the Rijnmond region, 1985-1993: more transmission via heterosexual contact and drug abuse and more female patients (letter)]
Ned Tijdschr Geneeskd. 1995 Apr 15;139(15):806. Unique Identifier : AIDSLINE MED/95240783
Tamsma N; de Zwart O; van Gerven PJ
Streptococcus pyogenes peritonitis associated with genital swelling and gastroenteritis caused by Cryptosporidium and Salmonella paratyphi B in an HIV infected patient on CAPD [letter]
Nephrol Dial Transplant. 1995;10(1):140-1. Unique Identifier : AIDSLINE MED/95240914
Abraham G
HIV-associated IgA nephropathy--a post-mortem study.
Nephrol Dial Transplant. 1995;10(1):35-8. Unique Identifier : AIDSLINE MED/95240922
Beaufils H; Jouanneau C; Katlama C; Sazdovitch V; Hauw JJ; INSERM U 192 Hopital des Enfants-Malades, Paris, France.
Between November 1983 and December 1991, we undertook a systematic study of kidney in deceased AIDS patients using light and immunofluorescence microscopy. Among the 116 examined kidneys (from 106 men and 10 women), nine (7.75%) showed diffuse mesangial IgA deposits. By light microscopy, glomerular lesions were absent


The impact of knowledge of human immunodeficiency virus serostatus on contraceptive choice and repeat pregnancy.
Obstet Gynecol. 1995 May;85(5 Pt 1):675-9. Unique Identifier : AIDSLINE MED/95240994
Lindsay MK; Grant J; Peterson HB; Willis S; Nelson P; Klein L; Department of Obstetrics and Gynecology, Emory University,; Atlanta, USA.
OBJECTIVE: To examine relationships among human immunodeficiency virus (HIV) serostatus, postpartum contraceptive choice, and the rate of repeat pregnancy within a short interval. METHODS: This retrospective cohort study was performed in 83 seropositive and 218 seronegative women identified from an inner-city prenatal


Human papillomavirus infection in human immunodeficiency virus-seropositive women.
Obstet Gynecol. 1995 May;85(5 Pt 1):680-6. Unique Identifier : AIDSLINE MED/95240995
Sun XW; Ellerbrock TV; Lungu O; Chiasson MA; Bush TJ; Wright TC Jr; Department of Pathology, College of Physicians and Surgeons,; Columbia University, New York, New York, USA.
OBJECTIVE: To compare the prevalence of human papillomavirus (HPV) infections in women who are seropositive and seronegative for human immunodeficiency virus (HIV), and to determine if associations between HPV and cervical disease are altered in HIV-seropositive women. METHODS: In this cross-sectional study, 344 HIV-s


Intravitreal cidofovir (HPMPC) treatment of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome [published erratum appears in Ophthalmology 1995 May;102(5):702]
Ophthalmology. 1995 Apr;102(4):533-42; discussion 542-3. Unique Identifier : AIDSLINE MED/95241071
Kirsch LS; Arevalo JF; Chavez de la Paz E; Munguia D; de Clercq E; Freeman WR; Department of Ophthalmology, Shiley Eye Center, University of; California at San Diego, La Jolla 92093-0946, USA.
PURPOSE: The authors previously conducted a pilot, dose-escalating study which suggested that a 20-micrograms dose of intravitreal cidofovir (HPMPC) may be safe and effective in treating cytomegalovirus ( CMV ) retinitis in hum


[Ras proteins and promoters of retroelements: the dangerous liaisons (editorial)]
Pathol Biol (Paris). 1994 Oct;42(8):743-6. Unique Identifier : AIDSLINE MED/95241161
Galien R
[Immunoglobulins E and human immunodeficiency virus infection (HIV)]
Pathol Biol (Paris). 1994 Oct;42(8):750-3. Unique Identifier : AIDSLINE MED/95241163
Fresard A; Vindimian M; Genin C; Le Petit JC; Pozzetto B; Lucht F; Service des Maladies Infectieuses et Tropicales, Hopital; Bellevue, CHU, ST-Etienne, France.
Except for Ig E, serum immunoglobulin abnormalities in persons with human immunodeficiency virus (HIV) infection have been well described. Serum IgE levels have been shown to rise with progressive disease. The authors evaluated IgE in 148 HIV-seropositive individuals with or without acquired immunodeficiency syndrome


[Current data on epidermal Langerhans cells]
Pathol Biol (Paris). 1994 Oct;42(8):767-74. Unique Identifier : AIDSLINE MED/95241166
Dezutter-Dambuyant C; Unite INSERM 346, Clinique Dermatologique, Pavillon R, Hopital; Edouard Herriot, Lyon, France.
The skin may be considered as well as a target and an initiator of self immune reactions. Two to 5% of the epidermal cells are Langerhans cells which are the only cells to specifically take, process and present the antigens to lymphocytes in order to induce an immune response. Such an ability and the location of the L


Severe cystic pulmonary disease associated with chronic Pneumocystis carinii infection in a child with AIDS.
Pediatr Radiol. 1994;24(8):606-8. Unique Identifier : AIDSLINE MED/95241211
Evlogias NE; Leonidas JC; Rooney J; Valderama E; Department of Radiology, Schneider Children's Hospital, New Hyde; Park, NY 11040, USA.
A 3-year-old HIV-positive boy developed Pneumocystis carinii pneumonia (PCP) resulting in chronic interstitial pulmonary disease, which persisted for the following 3 years; he was essentially asymptomatic and the lung findings had therefore been attributed to lymphocytic interstitial pneumonia (LIP). He subsequently d


Pneumatosis intestinalis in a child with AIDS and pseudomembranous colitis.
Pediatr Radiol. 1994;24(8):609-10. Unique Identifier : AIDSLINE MED/95241212
Burton EM; Mercado-Deane MG; Patel K; Department of Radiology, Medical College of Georgia, Augusta; 30912-3900, USA.
Pneumatosis intestinalis (PI) was first reported in three children and one adult with acquired immune deficiency syndrome (AIDS) in 1990. The microorganisms cultured from these patients included Cryptosporidium, rotavirus, cytomegalovirus , and Pseudomonas. We report the fourth chil


Cerebral infarction in pediatric acquired immunodeficiency syndrome.
Pediatr Radiol. 1994;24(8):611-2. Unique Identifier : AIDSLINE MED/95241213
Moriarty DM; Haller JO; Loh JP; Fikrig S; Department of Radiology, SUNY/Health Science Center at Brooklyn; 11203, USA.
Cerebral infarction is an uncommon complication of AIDS in pediatric patients. We have seen three HIV-infected children who developed acute neurological deficits due to stroke. Cerebral infarction must be considered in the work-up of a child with AIDS who presents with focal neurological deficit, seizure or mental sta


Older children and adolescents living with perinatally acquired human immunodeficiency virus infection.
Pediatrics. 1995 May;95(5):657-63. Unique Identifier : AIDSLINE MED/95241219
Grubman S; Gross E; Lerner-Weiss N; Hernandez M; McSherry GD; Hoyt LG; Boland M; Oleske JM; Department of Pediatrics, University of Medicine and Dentistry of; New Jersey-New Jersey Medical School, Newark, USA.
OBJECTIVE. To describe the clinical, immunologic, and psychosocial characteristics of children living with perinatally-acquired human immunodeficiency virus (HIV) infection beyond the age of 9 years. METHODS. This is a descriptive cohort study of 42 surviving perinatally infected children older than 9 years followed a


Unrecognized human immunodeficiency virus type 1 infection in a cohort of transfused neonates: a retrospective investigation.
Pediatrics. 1995 May;95(5):717-21. Unique Identifier : AIDSLINE MED/95241230
Lieb LE; Mundy TM; Goldfinger D; Pepkowitz SH; Brunell PA; Caldwell MB; Ward JW; Los Angeles County Department of Health Services, CA 90005, USA.
OBJECTIVE. To retrospectively identify unrecognized human immunodeficiency virus type 1 (HIV-1) infection among a cohort of children transfused as neonates before donated blood was routinely screened for HIV-1 antibody. METHODS. Records at a large, private, metropolitan hospital were reviewed to identify children who


Mother-to-infant HIV transmission: timing, risk factors and prevention.
Paediatr Perinat Epidemiol. 1995 Jan;9(1):1-29. Unique Identifier : AIDSLINE MED/95241330
Kuhn L; Stein ZA; Columbia University, Division of Epidemiology, Gertrude H.; Sergievsky Center, New York, NY 10032.
Identifying when--during pregnancy, delivery or the postnatal period--transmission of human immunodeficiency virus (HIV) from mother to infant usually takes place is critical to the development of methods to prevent maternal-infant transmission. Evidence is reviewed in this paper as to whether transmission occurs prep


Pneumocystis carinii pneumonia presenting with pneumomediastinum in an HIV-positive patient.
Postgrad Med J. 1995 Feb;71(832):96-7. Unique Identifier : AIDSLINE MED/95241367
Moss S; Carey PB; Hind CR; AIDS Clinical Group, Royal Liverpool University Hospital, UK.
A 19-year-old man presented with community-acquired pneumonia, complicated by pneumomediastinum. Subsequently he was found to be HIV-positive, and to have Pneumocystis carinii pneumonia.


[Ofloxacin-cycloserine-protionamide-INH combination against treatment refractory lung tuberculosis]
Pneumologie. 1995 Feb;49(2):72-6. Unique Identifier : AIDSLINE MED/95241431
Muhlberger F; Nturanye F; Nasbimana J; Portaels F; Sanatorium Gishari, Ruanda.
Multiresistant tuberculoses are on the increase. The conversion rates in additional therapy are only modest. 17 multiresistant patients and 6 treatment-refractory tuberculoses were treated by us with ofloxacin-cycloserin-protionamide-INH. 16 of these patients were HIV positive. 21 patients converted after 3 months of


Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam.
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3142-6. Unique Identifier : AIDSLINE MED/95241461
Nabors GS; Afonso LC; Farrell JP; Scott P; Department of Pathobiology, University of Pennsylvania,; Philadelphia 19104, USA.
Successful treatment in allergic, autoimmune, and infectious diseases often requires altering the nature of a detrimental immune response mediated by a particular CD4+ T helper (Th) cell subset. While several factors contribute to the development of CD4+ Th1 and Th2 cells, the requirements for switching an established


Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs.
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3283-7. Unique Identifier : AIDSLINE MED/95241487
Thormar H; Georgsson G; Palsson PA; Balzarini J; Naesens L; Torsteinsdottir S; De Clercq E; Institute of Biology, University of Iceland, Reykjavik.
The acyclic nucleoside phosphonate analog 9-(2-phosphonylmethoxyethyl)adenine (PMEA) was recently found to be effective as an inhibitor of visna virus replication and cytopathic effect in sheep choroid plexus cultures. To study whether PMEA also affects visna virus infection in sheep, two groups of four lambs each wer


Protein structure-based design of potent orally bioavailable, nonpeptide inhibitors of human immunodeficiency virus protease.
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3298-302. Unique Identifier : AIDSLINE MED/95241490
Reich SH; Melnick M; Davies JF 2nd; Appelt K; Lewis KK; Fuhry MA; Pino M; Trippe AJ; Nguyen D; Dawson H; et al; Agouron Pharmaceuticals, Inc., San Diego, CA 92121, USA.
A class of potent nonpeptidic inhibitors of human immunodeficiency virus protease has been designed by using the three-dimensional structure of the enzyme as a guide. By employing iterative protein cocrystal structure analysis, design, and synthesis the binding affinity of the lead compound was incrementally improved


Differential modulation of Th1- and Th2-related cytokine mRNA expression by a synthetic peptide homologous to a conserved domain within retroviral envelope protein [published erratum appears in Proc Natl Acad Sci U S A 1995 Sep 12;92(19):9009]
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3611-5. Unique Identifier : AIDSLINE MED/95241550
Haraguchi S; Good RA; James-Yarish M; Cianciolo GJ; Day NK; Department of Pediatrics, All Children's Hospital, University of; South Florida College of Medicine, St. Petersburg 33701, USA.
The influence of a synthetic retroviral peptide, CKS-17, on T helper type 1 (Th1)- or Th2-related cytokines was investigated in human blood mononuclear cells. Cells were stimulated with staphylococcal enterotoxin A, anti-CD3 plus anti-CD28 monoclonal antibodies, or lipopolysaccharide to induce cytokine mRNA. mRNA was


The glucocorticoid receptor type II complex is a target of the HIV-1 vpr gene product.
Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3621-5. Unique Identifier : AIDSLINE MED/95241552
Refaeli Y; Levy DN; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104, USA.
The vpr gene of human immunodeficiency virus type 1 (HIV-1) encodes a 15-kDa virion-associated protein that functions as a regulator of cellular processes linked to the HIV life cycle. We report the interaction of a 41-kDa cytosolic viral protein R interacting protein 1 (Rip-1) with Vpr in vitro. Rip-1 displays a wide


Fear of acquiring HIV is receding [news]
Prof Nurse. 1995 Apr;10(7):467. Unique Identifier : AIDSLINE MED/95241588
Obsessive-compulsive disorder in HIV disease. Response to fluoxetine.
Psychosomatics. 1995 Mar-Apr;36(2):147-50. Unique Identifier : AIDSLINE MED/95241669
McDaniel JS; Johnson KM; Grady Health System Infectious Disease Program, Department of; Psychiatry and Behavioral Sciences, Emory University School of; Medicine, Atlanta, GA.
Recent changes in consultation-liaison psychiatry. A blueprint for the future [see comments]
Psychosomatics. 1995 Mar-Apr;36(2):95-102. Unique Identifier : AIDSLINE MED/95241675
Cavanaugh S; Milne J; Department of Psychiatry, Rush-Presbyterian-St. Luke's Medical; Center, Chicago, IL 60612.
To better understand the changes in the past 5 years on consultation-liaison (C-L) services in the United States , 119 university programs were surveyed. The return response was 64%. Of the 76 respondents, 32% had decreased funding, 54% no changes or stable finding, and 14% improved fun


[AIDS in Naples in 1800. 12 cases of Kaposi sarcoma described by Tommaso de Amicis]
Pubbl Stn Zool Napoli [II]. 1994;16(2):275-309. Unique Identifier : AIDSLINE MED/95241677
Villone G; Dipartimento di Medicina Sperimentale, Clinica Universita degli; Studi di Reggio Calabria, Catanzaro, Italy.
In 1882, Tommaso de Amicis, dermatologist and venereologist at the University of Naples, Italy , published a description of twelve cases of Kaposi s sarcoma. This article is the second report about the above-mentioned disease after the first description of five cases by Moritz Kaposi


[History of virology, viral diseases, and virologists]
Pubbl Stn Zool Napoli [II]. 1994;16(2):339-54. Unique Identifier : AIDSLINE MED/95241678
Grmek MD; Ecole Pratiques des Hautes Etudes, Paris, France.
AIDS-related Kaposi sarcoma of the lung: radiographic findings and staging system with bronchoscopic correlation.
Radiology. 1995 May;195(2):545-52. Unique Identifier : AIDSLINE MED/95241736
Gruden JF; Huang L; Webb WR; Gamsu G; Hopewell PC; Sides DM; Department of Radiology, San Francisco General Hospital, CA; 94110, USA.
PURPOSE: To determine the chest radiographic findings in patients with tracheobronchial Kaposi sarcoma (KS) and to develop a radiographic staging system that allows comparison of radiographic to bronchoscopic findings and allows assessment of the typical temporal progression of pulmonary KS. MATERIALS AND METHODS: The


[Current epidemiology of tuberculosis]
Rev Pneumol Clin. 1994;50(3):106-15. Unique Identifier : AIDSLINE MED/95241931
Vaylet F; Allard P; Natali F; Marotel C; L'Her P; Service de Pneumologie, Hopital d'Instruction des Armees D.; Larrey, Versailles.
A major health threat in developing countries, the incidence of tuberculosis has decreased steadily in Western countries over the last century. However, since 1986, first in the United States , then more recently in several European countries, the number of declared cases has increased.


[Prevalence of pneumocystosis in HIV infected patients in a pneumology unit. Autopsy study performed in Abidjan (Cote d'Ivoire)]
Rev Pneumol Clin. 1994;50(3):116-20. Unique Identifier : AIDSLINE MED/95241932
Coulibaly G; N'Dhatz M; Domoua K; Aka-Danguy E; Traore F; Konan JB; Beaume A; Diomande M; Lucas S; Decock KM; et al; Service de Pneumophtisiologie, CHU de Treichville, Abidjan.
Autopsies were performed in the Pathology Department of the Treichville University Hospital, Abidjan, Ivory Coast in 70 HIV infected subjects who had died in the Department of Pneumophtisiology. The prevalence of Pneumocystis carinii pneumonia was determined. None of the patie


[Plurifocal alveolar pneumonia in a patient with AIDS: disseminated Mycobacterium avium intracellulare infection with difficult diagnosis]
Rev Pneumol Clin. 1994;50(3):124-7. Unique Identifier : AIDSLINE MED/95241934
Jacomet C; Sivignon F; Chatelet FP; Lebrette MG; Valette M; Rozenbaum W; Service des Maladies Infectieuses, Hopital Rothschild, Paris.
In patients with the acquired immunodeficiency syndrome (AIDS), manifestations of generalized Mycobacterium avium intracellulare infection are non-specific and pneumopathy is rarely encountered. We report a case of a patient with AIDS who had clinical and radiological manifestations of multifocal alveolar pneumopathy


[Pulmonary cryptococcosis: an uncommon opportunistic infection in AIDS on the Ivory Coast (letter)]
Rev Pneumol Clin. 1994;50(4):184-5. Unique Identifier : AIDSLINE MED/95241952
Domoua K; Coulibaly G; N'Dhatz MN; Traore F; Vagamon B; Edmond K; Beugre LK; Konan JB; Beaumel A; Yapi A
Activated CD4+ and CD8+ T-cell subsets in Wegener's granulomatosis.
Rheumatol Int. 1995;14(5):213-9. Unique Identifier : AIDSLINE MED/95241961
Schlesier M; Kaspar T; Gutfleisch J; Wolff-Vorbeck G; Peter HH; Abteilung Rheumatologie und klinische Immunologie, Medizinische; Universitatsklinik, Freiburg, Germany.
Several lines of evidence argue in favour of an involvement of T cells in the pathogenesis of Wegener s granulomatosis (WG). These include the presence of highly specific IgG autoantibodies to proteinase 3, perivascular T-cell infiltrates and elevated amounts of soluble interleukin-2 (


[The International Colloquium on the Econometrics of AIDS (news)]
Rev Sanid Hig Publica (Madr). 1993 Mar-Apr;67(2):165-7. Unique Identifier : AIDSLINE MED/95242052
V beta-specific activation of T cells by the HIV glycoprotein gp 160.
Scand J Immunol. 1995 May;41(5):487-98. Unique Identifier : AIDSLINE MED/95242065
Akolkar PN; Chirmule N; Gulwani-Akolkar B; Pahwa S; Kalyanaraman VS; Pergolizzi R; Macphail S; Silver J; Department of Medicine, North Shore University Hospital/Cornell; University Medical College, Manhasset, NY, USA.
Studies by several groups have suggested that HIV infection in vivo results in a V beta-specific alteration of the TCR repertoire and that this might play a role in the pathogenesis of AIDS. However, there is very little agreement as to which V beta segments are affected. In order to circumvent the confounding factors


Expression cloning of a protective Leishmania antigen.
Science. 1995 Apr 28;268(5210):563-6. Unique Identifier : AIDSLINE MED/95242101
Mougneau E; Altare F; Wakil AE; Zheng S; Coppola T; Wang ZE; Waldmann R; Locksley RM; Glaichenhaus N; Institut de Pharmacologie Moleculaire et Cellulaire, UPR411; CNRS, Valbonne, France.
Parasite-specific CD4+ T cells have been shown to transfer protection against Leishmania major in susceptible BALB/c mice. An epitope-tagged expression library was used to identify the antigen recognized by a protective CD4+ T cell clone. The expression library allowed recombinant proteins made in bacteria to be captu


Herpes-like sequences in HIV-infected and uninfected Kaposi's sarcoma patients [letter; comment]
Science. 1995 Apr 28;268(5210):582-3. Unique Identifier : AIDSLINE MED/95242107
Ambroziak JA; Blackbourn DJ; Herndier BG; Glogau RG; Gullett JH; McDonald AR; Lennette ET; Levy JA
Incentives can lower the incidence of HIV/AIDS in Africa [editorial]
Soc Sci Med. 1995 Feb;40(4):419-24. Unique Identifier : AIDSLINE MED/95242113
Good CM
The experience of an AIDS prevention program focused on South African traditional healers.
Soc Sci Med. 1995 Feb;40(4):503-15. Unique Identifier : AIDSLINE MED/95242123
Green EC; Zokwe B; Dupree JD; Department of Traditional Medicine, GEMT, Maputo, Mozambique.
A national HIV/STD prevention program focused on traditional healers was started in South Africa in late 1992. An initial group of 28 healers (the first generation ) was trained in HIV/AIDS and STD prevention. These 28 in turn trained a total of 630 additional healers (the secon


Detection of H-Y-reactive T lymphocytes in primary mixed lymphocyte reaction in DA rats.
Transplant Proc. 1995 Apr;27(2):1593-5. Unique Identifier : AIDSLINE MED/95242430
Sugiura W; Miyamoto M; Kimura H; Imada M; Tsujimura K; Honda M; Yamashita A; Department of Second Anatomy, Hamamatsu University School of; Medicine, Japan.
Graft-versus-host reactivity of rat T-cell subsets in isolated class I difference.
Transplant Proc. 1995 Apr;27(2):1596-7. Unique Identifier : AIDSLINE MED/95242431
Hasegawa T; Yamaguchi A; Li XK; Yokoi Y; Nakamura S; Baba S; Kimura H; Department of Research Surgery, National Children's Medical; Research Center, Tokyo, Japan.
Proliferative activity in the splenic compartment during hepatic allograft rejection in the rat.
Transplant Proc. 1995 Apr;27(2):1614-6. Unique Identifier : AIDSLINE MED/95242438
Yamaguchi Y; Misumi M; Hisama N; Miyanari N; Hamaguchi H; Ichiguchi O; Goto M; Mori K; Ogawa M; Department of Surgery II, Kumamoto University Medical School,; Japan.
Characterization of hepatic allograft infiltrates in rats pretreated with donor-specific blood transfusion: the role of OX-22(-)CD4+ Th2-like cells.
Transplant Proc. 1995 Apr;27(2):1622-4. Unique Identifier : AIDSLINE MED/95242441
Miyanari N; Yamaguchi Y; Hisama N; Ichiguchi O; Goto M; Hamaguchi H; Mori K; Ogawa M; Department of Surgery II, Kumamoto University Medical School,; Japan.
False-positive p24 antigenaemia detected in renal allograft recipients: possible role of rabbit antithymocyte globulins.
Transplant Proc. 1995 Apr;27(2):1738. Unique Identifier : AIDSLINE MED/95242498
Vincent F; Raynal N; Francois A; Belec L; Duboust A; Glotz D; Bariety J; Service de Nephrologie, Hopital Broussais, Paris, France.
Concurrent central nervous system toxoplasmosis and simian immunodeficiency virus-induced AIDS encephalomyelitis in a Barbary macaque (Macaca sylvana).
Vet Pathol. 1995 Jan;32(1):81-3. Unique Identifier : AIDSLINE MED/95242628
Sasseville VG; Pauley DR; MacKey JJ; Simon MA; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772-9102.
Analysis of leucocytes and lymphocyte subsets for different clinical stages of naturally acquired feline immunodeficiency virus infection.
Vet Immunol Immunopathol. 1994 Dec;44(1):1-12. Unique Identifier : AIDSLINE MED/95242651
Walker C; Canfield PJ; Love DN; Department of Veterinary Pathology, University of Sydney, N.S.W.,; Australia.
We report alterations in leucocytes numbers and lymphocyte subset percentages, determined by flow cytometry, for three observed and previously defined clinical stages (asymptomatic carrier (AC), AIDS-related complex (ARC) and AIDS) of naturally occurring FIV infection. Unstaged FIV-positive cats had significantly lowe


Immunopathology of experimental Jembrana disease in Bali cattle.
Vet Immunol Immunopathol. 1994 Dec;44(1):31-44. Unique Identifier : AIDSLINE MED/95242653
Dharma DM; Ladds PW; Wilcox GE; Campbell RS; Bali Cattle Disease Investigation Unit, Denpasar, Indonesia.
Sequential immunohistochemical studies of the lymphoreticular responses of Bali cattle (Bos javanicus syn. Bos sondaicus) after inoculation with the Jembrana disease virus were carried out using the peroxidase-antiperoxidase test for immunoglobulin containing cell assessment and the indirect immunoperoxidase test for


Prevalence of antibodies to HTLV-I/II in high-risk patients and blood donors in Denmark [letter]
Vox Sang. 1995;68(1):63-4. Unique Identifier : AIDSLINE MED/95242706
Christiansen CB; Wantzin P; Dickmeiss E
Making the health care system 'safe' for persons with HIV infection or AIDS.
West J Med. 1995 Mar;162(3):229-34. Unique Identifier : AIDSLINE MED/95242739
Kimball AM; Lafferty B; Shields A; Smyser M; Division of HIV/AIDS, Washington Department of Health, Seattle,; USA.
If health care reform is implemented in states and nationally, the safety of this process needs to be examined for persons with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS). Reform should assure ongoing prevention and transmission control of HIV and continuous coverage


Observation of T cell surface antigens in the clinical course of adult T-cell leukemia: case report of a spontaneous remission.
Acta Haematol. 1995;93(1):40-5. Unique Identifier : AIDSLINE MED/95242894
Suzuki M; Uno H; Kiyomizu A; Kubuki Y; Yamashita K; Maeda K; Matsuoka H; Tsuda K; Tsubouchi H; Second Department of Internal Medicine, Miyazaki Medical School,; Japan.
A patient with acute adult T-cell leukemia (ATL) in whom spontaneous remission was observed without any specific treatment having been given is described. The abnormal cell phenotype was CD4+, CD45RO+ and CD8-. As the number of abnormal cells decreased, CD4+ cell count decreased and CD8+ cells and CD45RA+ cells increa


Identification of an amino acid substitution involved in the reduction of sensitivity of HIV-1 to an inhibitor of viral proteinase.
Acta Virol. 1994 Oct;38(5):297-8. Unique Identifier : AIDSLINE MED/95243063
Turriziani O; Antonelli G; Jacobsen H; Mous J; Riva E; Pistello M; Dianzani F; Institute of Virology, University La Sapienza, Rome, Italy.
Clones derived from HIV variants previously characterized as resistant to Ro31-8959, an inhibitor of viral proteinase (PR), were sequenced. Substitution of glycine by valine at position 48 of the PR protein was found. None of the 20 clones derived from wild type HTLV-IIIB contain this mutation. Since such a position i


Topics in protozoal diseases [letter; comment]
Am J Clin Pathol. 1995 Apr;103(4):535. Unique Identifier : AIDSLINE MED/95243214
Laguna F; Gonzalez-Lahoz JM
Yes, put on gloves, but also take them off [letter; comment]
Anesth Analg. 1995 May;80(5):1066. Unique Identifier : AIDSLINE MED/95243496
Cullen BF
[Current aspects of laryngeal tuberculosis. Apropos of 4 cases and review of the literature]
Ann Otolaryngol Chir Cervicofac. 1994;111(4):201-7. Unique Identifier : AIDSLINE MED/95243556
Gallas D; Coste A; Bedbeder P; Peynegre R; Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale,; Centre Hospitalier Intercommunal de Creteil.
After the discovery of streptomycin 1944, laryngeal tuberculosis became a rare complication of advanced pulmonary tuberculosis. Since that time the clinical aspects of the disease have changed. We analyzed these changes by reviewing 65 papers in English and in French published from 1965 to 1991 involving 738 cases and


Inhibition of human immunodeficiency virus integrase by bis-catechols.
Antimicrob Agents Chemother. 1995 Feb;39(2):320-4. Unique Identifier : AIDSLINE MED/95243569
LaFemina RL; Graham PL; LeGrow K; Hastings JC; Wolfe A; Young SD; Emini EA; Hazuda DJ; Department of Antiviral Research, Merck Research Laboratories,; West Point, Pennsylvania 19486, USA.
The human immunodeficiency virus type 1 (HIV-1) integrase protein is required for the productive infection of T-lymphoid cells in culture (R. L. LaFemina, C. L. Schneider, H. L. Robbins, P. L. Callahan, K. LeGrow, E. Roth, W. A. Schleif, and E. A. Emini, J. Virol. 66:7414-7419, 1992). This observation suggests that ch


Effect of zidovudine on transplacental pharmacokinetics of ddI in the pigtailed macaque (Macaca nemestrina).
Antimicrob Agents Chemother. 1995 Feb;39(2):343-5. Unique Identifier : AIDSLINE MED/95243574
Pereira CM; Nosbisch C; Baughman WL; Unadkat JD; Department of Pharmaceutics, BG-20, University of Washington,; Seattle 98195, USA.
Since zidovudine and ddI may be used in combination in the future to treat pregnant women who are human immunodeficiency virus positive, we conducted a study to determine whether zidovudine affects the transfer of ddI across the placenta. Zidovudine and ddI were infused simultaneously to three near-term pregnant macaq


Antiviral properties of aminodiol inhibitors against human immunodeficiency virus and protease.
Antimicrob Agents Chemother. 1995 Feb;39(2):374-9. Unique Identifier : AIDSLINE MED/95243581
Bechtold CM; Patick AK; Alam M; Greytok J; Tino JA; Chen P; Gordon E; Ahmad S; Barrish JC; Zahler R; et al; Department of Virology, Bristol-Myers Squibb Pharmaceutical; Research Institute, Wallingford, Connecticut 06492-7660, USA.
A series of aminodiol inhibitors of human immunodeficiency virus type 1 (HIV-1) protease were identified by using an in vitro peptide cleavage assay. BMS 182,193, BMS 186,318, and BMS 187,071 protected cells against HIV-1, HIV-2, and simian immunodeficiency virus infections, with 50% effective doses ranging from 0.05


Detection of HIV-specific DNA sequences in epidermal Langerhans cells infected in vitro by means of a cell-free system.
Arch Dermatol Res. 1994;287(1):36-41. Unique Identifier : AIDSLINE MED/95243718
Charbonnier AS; Mallet F; Fiers MM; Desgranges C; Dezutter-Dambuyant C; Schmitt D; Unite INSERM 346, Clinique Dermatologique, Hopital Edouard; Herriot, Lyon, France.
As dendritic antigen-presenting cells in skin and mucous membranes, Langerhans cells (LC) are found in areas at risk of inoculation by the human immunodeficiency virus (HIV). LC have been reported as targets for HIV-1. The aim of the present study was to investigate whether LC can be experimentally infected by HIV pro


Multi drug resistant tuberculosis: what will happen in developing countries? [editorial]
Ann Soc Belg Med Trop. 1994 Dec;74(4):263-7. Unique Identifier : AIDSLINE MED/95243746
Colebunders R; Dujardin B; Taelman H; Portaels F
Zidovudine compared with didanosine in patients with advanced HIV type 1 infection and little or no previous experience with zidovudine. AIDS Clinical Trials Group [published erratum appears in Arch Intern Med 1995 Nov 13;155(20):2255]
Arch Intern Med. 1995 May 8;155(9):961-74. Unique Identifier : AIDSLINE MED/95243794
Dolin R; Amato DA; Fischl MA; Pettinelli C; Beltangady M; Liou SH; Brown MJ; Cross AP; Hirsch MS; Hardy WD; et al; Department of Medicine, University of Rochester (NY) School of; Medicine and Dentistry, USA.
BACKGROUND: We conducted a trial to compare treatment with zidovudine or didanosine in patients with advanced human immunodeficiency virus type 1 (HIV-1) infection who had received little or no previous therapy with zidovudine. METHODS: Six hundred seventeen patients with acquired immunodeficiency syndrome (AIDS), adv


AIDS-associated Kaposi's sarcoma. Duesberg phenomenon' [letter; comment] [see comments]
Science. 1995 Feb 24;267(5201):1080. Unique Identifier : AIDSLINE MED/95232481
Ascher MS; Sheppard HW
Crack cocaine and HIV in the inner city [letter; comment]
N Engl J Med. 1995 May 4;332(18):1233; discussion 1234-5. Unique Identifier : AIDSLINE MED/95214715
Sugarman K; Herman M
Envelope V2 configuration and HIV-1 phenotype: clarification [letter; comment]
Science. 1995 Apr 7;268(5207):115. Unique Identifier : AIDSLINE MED/952