Non-cytotoxic, IL-4, IL-5, IL-10 producing CD8+ T cells: their activation and effector functions. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Non-cytotoxic, IL-4, IL-5, IL-10 producing CD8+ T cells: their activation and effector functions.

Curr Opin Immunol. 1994 Jun;6(3):453-7. Unique Identifier : AIDSLINE MED/95000400
Le Gros G; Erard F; Department of Allergy/Immunology, Ciba-Geigy Ltd, Switzerland.

Abstract: CD8+ T cells activated in the presence of IL-4 can develop into distinct, non-cytotoxic CD8- and cytotoxic CD8+ subsets that produce IL-4, IL-5, IL-10 but do not produce IFN-gamma. These 'Th2 like' CD8+ cells may enhance Th2 responses, help B cells or suppress Th1 immune responses. Importantly, the switch from the cytotoxic, IFN-gamma producing CD8+ T-cell phenotype could compromise the host response to infectious agents such as HIV.
Keywords: Acquired Immunodeficiency Syndrome/IMMUNOLOGY Animal B-Lymphocytes/IMMUNOLOGY CD8-Positive T-Lymphocytes/*IMMUNOLOGY Human Interleukin-10/BIOSYNTHESIS Interleukin-4/BIOSYNTHESIS Interleukin-5/BIOSYNTHESIS Lymphocyte Transformation/*IMMUNOLOGY T-Lymphocytes, Helper-Inducer/IMMUNOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDacquiredimmunodeficiencysyndrome/immunologyanimalb-lymphocytes/immunologycd8-positivet-lymphocytes/KWDimmunologyhumaninterleukin-10/biosynthesisinterleukin-4/biosynthesisinterleukin-5/biosynthesislymphocytetransformation/KWDimmunologyt-lymphocytes,helper-inducer/immunologyjournalarticlereviewreview,tutorial
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