Synthesis of some new heterobicyclic compounds containing spiro-1,2,4-triazine moiety as potential anti HIV and anticancer agents. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Synthesis of some new heterobicyclic compounds containing spiro-1,2,4-triazine moiety as potential anti HIV and anticancer agents.

Boll Chim Farm. 1994 Jun;133(6):374-80. Unique Identifier : AIDSLINE MED/95000476
Abdel-Rahman RM; Seada M; Fawzy M; el-Baz I; Department of Chemistry, Faculty of Education, Ain-Shams; University, Roxy, Cairo, Egypt.

Abstract: A number of heterobicyclic compounds such as 1,3,5-thiazine, thiazolidinone, pyrimidine, pyrimidinedione, imidazole, quinazolinone and 1,2,4-triazinone derivatives have been synthesized by interaction of 1,6-dihydro-3 (2H)-thioxo-6-spiro-(9'-fluorene)-1,2,4-triazin-5(4H)-one (1) with sulphur/nitrogen compounds in neutral or alkaline medium. Structure elucidation of the new compounds has been carried out with the help of elemental analysis and spectral data. Some of these compounds were tested for in vitro anti HIV and anticancer activities.
Keywords: Antineoplastic Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY Antiviral Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY Drug Screening Assays, Antitumor Human HIV/*DRUG EFFECTS Spiro Compounds/*CHEMICAL SYNTHESIS/PHARMACOLOGY Triazines/*CHEMICAL SYNTHESIS/PHARMACOLOGY Tumor Cells, Cultured JOURNAL ARTICLEKWDantineoplasticagents/KWDchemicalsynthesis/pharmacologyantiviralagents/KWDchemicalsynthesis/pharmacologydrugscreeningassays,antitumorhumanhiv/KWDdrugeffectsspirocompounds/KWDchemicalsynthesis/pharmacologytriazines/KWDchemicalsynthesis/pharmacologytumorcells,culturedjournalarticle
950130
M9510856

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