Synthesis of some new 1,6-dihydro-3-substituted-6-spiro-(9'-fluorene)-1,2,4-triazin-5-( 4H)-on es as potential anti HIV and anticancer drugs. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Synthesis of some new 1,6-dihydro-3-substituted-6-spiro-(9'-fluorene)-1,2,4-triazin-5-( 4H)-on es as potential anti HIV and anticancer drugs.

Boll Chim Farm. 1994 Jun;133(6):381-8. Unique Identifier : AIDSLINE MED/95000477
Abdel-Rahman RM; Seada M; Fawzy M; el Baz I; Department of Chemistry, Faculty of Education, Ain Shams; University Roxy, Cairo, Egypt.

Abstract: 1,6-Dihydro-3 (2H)-thioxo-6-spiro-(9'-fluorene)-1,2,4-triazin-5(4H)-one (1) has been used to synthesize several analogous compounds via nucleophilic substitution reactions. Spectroscopic data are given in support of the proposed structures. Some of the new products possessed good anti HIV and anticancer activities.
Keywords: Antineoplastic Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY Antiviral Agents/*CHEMICAL SYNTHESIS/PHARMACOLOGY Drug Screening Assays, Antitumor Human HIV/*DRUG EFFECTS Spiro Compounds/*CHEMICAL SYNTHESIS/PHARMACOLOGY Triazines/*CHEMICAL SYNTHESIS/PHARMACOLOGY Tumor Cells, Cultured JOURNAL ARTICLEKWDantineoplasticagents/KWDchemicalsynthesis/pharmacologyantiviralagents/KWDchemicalsynthesis/pharmacologydrugscreeningassays,antitumorhumanhiv/KWDdrugeffectsspirocompounds/KWDchemicalsynthesis/pharmacologytriazines/KWDchemicalsynthesis/pharmacologytumorcells,culturedjournalarticle
950130
M9510855

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