Genetic analysis of HIV-1 isolates from Brazil reveals presence of two distinct genetic subtypes. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Genetic analysis of HIV-1 isolates from Brazil reveals presence of two distinct genetic subtypes.

AIDS Res Hum Retroviruses. 1994 May;10(5):561-7. Unique Identifier : AIDSLINE GENBANK/L22088
Louwagie J; Delwart EL; Mullins JI; McCutchan FE; Eddy G; Burke DS; Henry M. Jackson Foundation Research Laboratory, Rockville,; Maryland 20850.

Abstract: The spread of the human immunodeficiency virus type 1 (HIV-1) is by now virtually worldwide. An understanding of the genetic, biological, and immunological differences among isolates collected in different geographic locales is crucial for the development of globally effective vaccines. Here we report the genetic characteristics of 21 HIV-1 isolates from Brazil. The isolates were initially characterized using a heteroduplex mobility assay. The majority (17 of 21) were related to North American/European reference isolates of genetic subtype B. Four isolates belonged to a more recently identified genotype, termed subtype F. The subtype F sequences from Brazil are distinguishable in both gag and env from five other genetic subtypes of HIV-1 currently recognized. Like many locales, Brazil harbors more than one HIV-1 subtype.
Keywords: Amino Acid Sequence AIDS Vaccines/ISOLATION & PURIF Brazil Comparative Study Gene Products, env/GENETICS Gene Products, gag/GENETICS Genes, env Genes, gag Human HIV Envelope Protein gp120/GENETICS HIV Infections/*MICROBIOLOGY HIV-1/CLASSIFICATION/*GENETICS/*ISOLATION & PURIF Molecular Sequence Data Nucleic Acid Heteroduplexes/GENETICS Peptide Fragments/GENETICS Phylogeny Sequence Homology, Amino Acid Species Specificity Support, U.S. Gov't, P.H.S. JOURNAL ARTICLEKWDaminoacidsequenceaidsvaccines/isolation&purifbrazilcomparativestudygeneproducts,env/geneticsgeneproducts,gag/geneticsgenes,envgenes,gaghumanhivenvelopeproteingp120/geneticshivinfections/KWDmicrobiologyhiv-1/classification/KWDgenetics/KWDisolation&purifmolecularsequencedatanucleicacidheteroduplexes/geneticspeptidefragments/geneticsphylogenysequencehomology,aminoacidspeciesspecificitysupport,uKWDsKWDgov't,pKWDhKWDsKWDjournalarticle
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M9510841

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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