Absence of foamy virus DNA in Graves' disease. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Absence of foamy virus DNA in Graves' disease.

AIDS Res Hum Retroviruses. 1994 May;10(5):601-5. Unique Identifier : AIDSLINE MED/95000933
Schweizer M; Turek R; Reinhardt M; Neumann-Haefelin D; Abteilung Virologie, Universitat Freiburg, Germany.

Abstract: A report on the high prevalence of foamy virus DNA in lymphocytes from French patients with Graves' disease prompted us to investigate a similar cohort of 41 German patients. Using PCR amplification and Southern blot hybridization, we detected foamy virus DNA only in lymphocytes of two accidentally infected humans and five naturally infected monkeys, as well as in DNA samples from four Graves' disease patients investigated in the French study. However, we failed to detect foamy virus DNA in peripheral blood lymphocytes from any of the 41 Graves' disease patients of the German cohort. Thus, a causative role of foamy viruses in this thyroid disease is highly improbable.
Keywords: Adult Aged Aged, 80 and over Base Sequence Cohort Studies DNA Primers/GENETICS DNA, Viral/*GENETICS/*ISOLATION & PURIF Female Genes, myc Genes, pol Germany Graves' Disease/ETIOLOGY/*MICROBIOLOGY Human Lymphocytes/MICROBIOLOGY Male Middle Age Molecular Sequence Data Spumavirus/*GENETICS/*ISOLATION & PURIF/PATHOGENICITY Support, Non-U.S. Gov't JOURNAL ARTICLEKWDadultagedaged,80andoverbasesequencecohortstudiesdnaprimers/geneticsdna,viral/KWDgenetics/KWDisolation&puriffemalegenes,mycgenes,polgermanygraves'disease/etiology/KWDmicrobiologyhumanlymphocytes/microbiologymalemiddleagemolecularsequencedataspumavirus/KWDgenetics/KWDisolation&purif/pathogenicitysupport,non-uKWDsKWDgov'tjournalarticle
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