1995

[Document de reference sur les maladies de type viral pour les centres de readaptation : SIDA et hepatite B.]: centres de readaptation pour jeunes en difficulte d'adaptation Montreal : Association des centres d'accueil du Quebec, [1990] v. : ill Unique Identifier : AIDSLINE CAT/9404388
AIDS & health news. Began in 1990.: Lusaka, Zambia : Kara Counselling, v. : ill Unique Identifier : AIDSLINE CAT/9416512
[Con su propio lenguaje : SIDA, una nueva experiencia educativa con y desde los jovenes.]: [San Jose] : Asociacion Demografica Costarricense, [1991] vii, 86 p. : ill., ports Unique Identifier : AIDSLINE CAT/9412473; Gamboa J
[Imagerie du SIDA.]: Paris : Medecine-sciences Flammarion, c1991 viii, 106 p. : ill (Imagerie medicale) Unique Identifier : AIDSLINE CAT/9407141; Nahum H
Executive summary : America living with AIDS.: Syndrome [Washington, D.C.] : National Commission on AIDS, [1991] [27] p Unique Identifier : AIDSLINE CAT/9414465
Living in an AIDS culture.: Pretoria : University of South Africa, c1991 ix, 55 p. : ill Unique Identifier : AIDSLINE CAT/9418727; Van Arkel Jd
Report of a one-day Seminar on Women and AIDS for CCAM National and Regioanl [sic] Steering Committee Members : Kwacha Conference Centre, Blantyre : 17th January, 1991.: Steering Committee Members [Blantyre, Malawi? : s.n., 1991] 52 leaves Unique Identifier : AIDSLINE CAT/9414532
AIDS in South Africa : facts, figures, and the future--. 1st ed.: Petervale : Conservative Alliance, 1991 40 p Unique Identifier : AIDSLINE CAT/9414514; Quirke PD
AIDS, causes and prevention. 1st ed.: New Delhi : Mittal Publications, 1992 x, 138 p. : ill Unique Identifier : AIDSLINE CAT/9413406; Jaiswal TB
Battling the rising tide of tuberculosis : an approach to the American and African epidemics.: [Boston] : Malcolm Wiener Center for Social Policy, John F. Kennedy School of Government, Harvard University, c1992 62 p. : ill (Working paper series / Malcolm Wiener Center for Social Policy) Unique Identifier : AIDSLINE CAT/9432146; Heymann J
The:acquired immune deficiency syndrome (AIDS) : 22 January 1988-23 December 1989.: [Botswana] : University of Botswana, [1992] 101 p. : ill., ports (Press cuttings ; no. 7) Unique Identifier : AIDSLINE CAT/9414528; Kwafo-Akoto KO
The:acquired immune deficiency syndrome (AIDS) : 5 January 1990-19 December 1991.: [Botswana] : University of Botswana, [1992] 94 p. : ill., ports (Press cuttings ; no. 8) Unique Identifier : AIDSLINE CAT/9414529; Kwafo-Akoto KO
HIV/AIDS and the law in Kenya : preliminary observations.: Nairobi, Kenya : Institute for Development Studies, University of Nairobi, [1992] 37 p (Working paper ; no. 484) Unique Identifier : AIDSLINE CAT/9414804; Kibwana K
[Les:combattants du SIDA.]: [France?] : Flammarion, c1993 249 p Unique Identifier : AIDSLINE CAT/9414306; Martet C
Too young to die. Rev.: Lusaka : Zambia Educational Pub. House, 1993 56 p Unique Identifier : AIDSLINE CAT/9439786; Mukonde CW
[Umweltschaden AIDS? : Hintergrunde einer biologischen Katastrophe.] Vollstandig uberarbeitete und erw. Aufl.: Bern : Zytglogge, c1993 231 p (Zytabu ; Nr. 16) Unique Identifier : AIDSLINE CAT/9433269; Jensen R
The:promise & the power : public policy analysis & the AIDS movement.: Las Colinas : Monument Press, 1993 xxix, 153 p. : port (The politics of AIDS ; v. 1) Unique Identifier : AIDSLINE CAT/9442014; Dickerson NA
[Aktuell : das Magazin der Deutschen AIDS-Hilfe.]: Berlin : Deutschen AIDS-Hilfe, v. : ill., ports Unique Identifier : AIDSLINE CAT/9435403
Civil Rights : HIV testing, contact tracing, & quarantine.: Las Colinas, Tex. : Monument Press, 1993 ix, 230 p. : port (The Politics of AIDS ; v. 2) Unique Identifier : AIDSLINE CAT/9441829; Dickerson NA
Nursing approaches to HIV/AIDS care. 3rd ed.: La Mesa, CA : Western Schools, c1993 i, 216, [10] p. : ill Unique Identifier : AIDSLINE CAT/9438087; Lamke C
[SIDA et prostitution au Cameroun.]: Paris : L'Harmattan, c1993 99 p Unique Identifier : AIDSLINE CAT/9419128; Beat-Songue P
Partner notification in the HIV context : a critical policy assessment.: San Francisco : AIDS Legal Referral Panel, [c1994] iii, 56, 23 p Unique Identifier : AIDSLINE CAT/9439792; Doughty R
The:confidentiality of HIV-related information : responding to the resurgence of aggressive public health interventions in the AIDS epidemic.: San Francisco, CA : AIDS Legal Referral Panel, [c1994] p. 111-184 Unique Identifier : AIDSLINE CAT/9439793; Doughty R
Altering the image of AIDS.: Amsterdam : VU University Press, 1994 130 p. : ill (Primary health care publications, ISSN 0926-9827 ; 8) Unique Identifier : AIDSLINE CAT/9437420; Bruyn Md
A:prescription for preventing AIDS : cure the body politic of prejudice.: Las Colinas, Tex. : Monument Press, 1994 ix, 175 p. : port (The Politics of AIDS series ; v. 3) Unique Identifier : AIDSLINE CAT/9442015; Dickerson NA
How i cured myself of AIDS : a self-treatment handbook of procedures for treating HIV positive and AIDS conditions. Rev. ed.: [Jerico Springs, Mo. : Behr & Lamb, Inc., 1994] vii, 65 p. : ill., port Unique Identifier : AIDSLINE CAT/9439174; Lamb WA
Seventh research project on AIDS, 1994 : progress report : Rome, July 4-8, 1994.: Roma : Ministerio della sanita, Istituto superiore di sanita, 1994 395 p (Rapporti ISTISAN, ISSN 0391-1675 ; ISTISAN 94/3) Unique Identifier : AIDSLINE CAT/9441481
Simian immunodeficiency virus.: Berlin ; New York : Springer-Verlag, c1994 viii, 241 p. : ill (Current topics in microbiology and immunology, ISSN 0070-217X ; 188) Unique Identifier : AIDSLINE CAT/9439144; Letvin NL; Desrosiers RC
Plague doctors : responding to the AIDS epidemic in France and America.: Westport, Conn. : Bergin & Garvey, 1995 viii, 273 p. : ill Unique Identifier : AIDSLINE CAT/9442840; Feldman JL
[Preliminary screening for antiviral AIDS drugs. I. Report on fiscal year 1988]: Eisei Shikenjo Hokoku. 1990;(108):128-31. Unique Identifier : AIDSLINE MED/95004373; Miki T; Ohnuki N; Shinkai T; Yabuuchi K; Ono T; Ohtomo N; Matsuda Y; Matsuyama M; Akiyoshi K; Ohtake T; et al; Preliminary screening for antiviral AIDS drugs has been carried out, using three different in vitro assay systems. Among 105 samples tested, 13 were found to inhibit the growth of HIV in vitro. Eleven of 13 were well-known anti-HIV chemicals, while the remaining two of plant origin were new chemicals whose anti-HIV ac
[Preliminary screening for antiviral AIDS drugs. II. Report on fiscal year 1989]: Eisei Shikenjo Hokoku. 1991;(109):107-10. Unique Identifier : AIDSLINE MED/95004407; Noro S; Sato N; Sakurada N; Fujita N; Ishizaki T; Kamimura N; Yoshida Y; Ono T; Ohtomo N; Matsuda Y; et al; Preliminary screening for antiviral AIDS drugs was carried out using three different in vitro assay systems. Among 104 samples tested, six were found to inhibit the growth of HIV in vitro. Four of six were acidic polysaccharides of sea weed origin and one was a well-known anti HIV chemical whose anti-HIV activity has
[Preliminary screening for antiviral AIDS drugs. III. Report on fiscal year 1990]: Eisei Shikenjo Hokoku. 1992;(110):88-91. Unique Identifier : AIDSLINE MED/95004480; Ohtake T; Mori H; Morimoto M; Ueba N; Kunita N; Matsuda Y; Matsuyama M; Akiyoshi K; Noro S; Sato N; et al; Preliminary screening for antiviral AIDS drugs has been carried out using three different in vitro assay systems. Among 106 samples tested, five were found to inhibit the growth of HIV in vitro. Two of five have a hopeful sign, as the range of effective doses of the samples is wide.
[The characteristics of the psychological care for HIV-infected patients]: Vrach Delo. 1992 Jan;(1):100-2. Unique Identifier : AIDSLINE MED/95027844; Frolov AF; Shabarova ZA; Kobysha IuV
[AIDS and the lung in 1994 (editorial)]: Ann Pathol. 1994;14(4):15. Unique Identifier : AIDSLINE MED/95000001; Capron F
[Pulmonary involvement in the course of human immunodeficiency virus infection. Part one: physiopathogenic mechanisms, diagnostic approach, infectious complications (see comments)]: Ann Pathol. 1994;14(4):209-20. Unique Identifier : AIDSLINE MED/95000003; Kambouchner M; Amouroux J; Service d'Anatomie et de Cytologie Pathologiques, Hopital; Avicenne, Bobigny.
[Pulmonary involvement in the course of human immunodeficiency virus. Part two: non-infectious complications]: Ann Pathol. 1994;14(4):221-6. Unique Identifier : AIDSLINE MED/95000004; Kambouchner M; Amouroux J; Service d'Anatomie et de Cytologie Pathologiques, Hopital; Avicenne, Bobigny.
Internal medicine residents' skills at identification of HIV-risk behavior and HIV-related disease.: Acad Med. 1994 Oct;69(10 Suppl):S45-7. Unique Identifier : AIDSLINE MED/95000095; Curtis JR; Paauw DS; Wenrich MD; Carline JD; Ramsey PG; University of Washington, Seattle 98195.
Management of antiretroviral drug therapy in human immunodeficiency virus infection.: Crit Rev Clin Lab Sci. 1994;31(2):169-96. Unique Identifier : AIDSLINE MED/95000289; Stretcher B; Department of Pathology and Laboratory Medicine, University of; Cincinnati College of Medicine, Ohio 45267-0714.; Nucleoside analog reverse transcriptase inhibitors, including zidovudine, didanosine, and zalcitabine, remain the cornerstone of therapy against human immunodeficiency virus (HIV) infection, the cause of AIDS. Although therapeutic regimens have been designed that are effective in slowing the progression of disease, th
Adverse effects of drugs used in the management of opportunistic infections associated with HIV infection.: Drug Saf. 1994 Jun;10(6):439-54. Unique Identifier : AIDSLINE MED/95000357; Peters BS; Carlin E; Weston RJ; Loveless SJ; Sweeney J; Weber J; Main J; Academic Department of Genitourinary Medicine and Communicable; Diseases, St Mary's Hospital, London, England.; Pneumocystis carinii pneumonia (PCP) is one of the most common AIDS-defining diagnoses. First-line therapy is cotrimoxazole (trimethoprim-sulfamethoxazole), despite a high incidence of toxic effects, and a greater incidence of hypersensitivity reactions among HIV-positive patients compared with the seronegative popula
Non-cytotoxic, IL-4, IL-5, IL-10 producing CD8+ T cells: their activation and effector functions.: Curr Opin Immunol. 1994 Jun;6(3):453-7. Unique Identifier : AIDSLINE MED/95000400; Le Gros G; Erard F; Department of Allergy/Immunology, Ciba-Geigy Ltd, Switzerland.; CD8+ T cells activated in the presence of IL-4 can develop into distinct, non-cytotoxic CD8- and cytotoxic CD8+ subsets that produce IL-4, IL-5, IL-10 but do not produce IFN-gamma. These Th2 like CD8+ cells may enhance Th2 responses, help B cells or suppress Th1 immune responses. Importantly, the switch from the cyt
Synthesis of some new heterobicyclic compounds containing spiro-1,2,4-triazine moiety as potential anti HIV and anticancer agents.: Boll Chim Farm. 1994 Jun;133(6):374-80. Unique Identifier : AIDSLINE MED/95000476; Abdel-Rahman RM; Seada M; Fawzy M; el-Baz I; Department of Chemistry, Faculty of Education, Ain-Shams; University, Roxy, Cairo, Egypt.; A number of heterobicyclic compounds such as 1,3,5-thiazine, thiazolidinone, pyrimidine, pyrimidinedione, imidazole, quinazolinone and 1,2,4-triazinone derivatives have been synthesized by interaction of 1,6-dihydro-3 (2H)-thioxo-6-spiro-(9 -fluorene)-1,2,4-triazin-5(4H)-one (1) with sulphur/nitrogen compounds in neut
Synthesis of some new 1,6-dihydro-3-substituted-6-spiro-(9'-fluorene)-1,2,4-triazin-5-( 4H)-on es as potential anti HIV and anticancer drugs.: Boll Chim Farm. 1994 Jun;133(6):381-8. Unique Identifier : AIDSLINE MED/95000477; Abdel-Rahman RM; Seada M; Fawzy M; el Baz I; Department of Chemistry, Faculty of Education, Ain Shams; University Roxy, Cairo, Egypt.; 1,6-Dihydro-3 (2H)-thioxo-6-spiro-(9 -fluorene)-1,2,4-triazin-5(4H)-one (1) has been used to synthesize several analogous compounds via nucleophilic substitution reactions. Spectroscopic data are given in support of the proposed structures. Some of the new products possessed good anti HIV and anticancer activities.
Tracheotomy in patients with acquired immunodeficiency syndrome. Is it necessary?: Arch Otolaryngol Head Neck Surg. 1994 Oct;120(10):1126-9. Unique Identifier : AIDSLINE MED/95000523; Thomas GR; Myers EM; Nunez A; Department of Otolaryngology-Head and Neck Surgery, Georgetown; University School of Medicine, Washington, DC.; OBJECTIVE: Patients with acquired immunodeficiency syndrome (AIDS) who develop respiratory failure and require mechanical ventilation have mortality rates of 85%. Tracheotomies are performed in this patient population for prolonged intubation. However, to date, objective data on tracheotomy in patients with AIDS are l
Serum antibodies from MS patients do not recognize HTLV-I, HIV-1, HIV-2 and SIV.: APMIS. 1994 Jul;102(7):514-20. Unique Identifier : AIDSLINE MED/95000583; Brokstad KA; Kalland KH; Page M; Nyland H; Haaheim L; Department of Microbiology and Immunology, Gade Institute,; University of Bergen, Norway.; A retroviral aetiology has been proposed for multiple sclerosis (MS). Although there is as yet no definitive evidence of viral involvement, there have been preliminary reports of antiretroviral antibody detection in sera from MS patients. Such sera have, for example, been found to react with HTLV-I. We here describe i
Interaction between Mycobacterium avium and human immunodeficiency virus type 1 (HIV-1) in bronchoalveolar macrophages of normal and HIV-1-infected subjects.: Am J Respir Cell Mol Biol. 1994 Oct;11(4):487-95. Unique Identifier : AIDSLINE MED/95000691; Denis M; Ghadirian E; Pulmonary Research Unit, Faculty of Medicine, University of; Sherbrooke, Quebec, Canada.; Bronchoalveolar lavage (BAL) macrophages from patients with symptomatic or asymptomatic HIV-1 infections were obtained, and their ability to restrict in vitro the growth of an AIDS-associated strain of Mycobacterium avium was compared with cells obtained from normal volunteers. BAL macrophage populations from HIV-1-in
Burkitt's like lymphoma in patients with and without HIV infection. A report of 33 patients from north-east Italy.: Acta Oncol. 1994;33(5):507-11. Unique Identifier : AIDSLINE MED/95000737; Vaccher E; Tirelli U; Division of Medical Oncology, Centro di Riferimento Oncologico,; Aviano, Italy.; With the aim of comparing the clinical features of Burkitt s like lymphoma (BL) in HIV-infected patients and in the general population, we retrospectively analyzed 35 patients with HIV-positive non-Hodgkin s lymphoma (NHL) and 535 patients with HIV-negative NHL, from 1985 to 1990.
Failure to disclose HIV risk among gay and bisexual men attending sexually transmitted disease clinics.: Am J Prev Med. 1994 May-Jun;10(3):125-9. Unique Identifier : AIDSLINE MED/95000834; Doll LS; Harrison JS; Frey RL; McKirnan D; Bartholow BN; Douglas JM Jr; Joy D; Bolan G; Doetsch J; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, GA 30333.; We analyzed data from a multisite study of 1,063 gay or bisexual men attending sexually transmitted disease clinics to evaluate factors predicting failure to disclose human immunodeficiency virus (HIV) risk behaviors to clinic staff and the extent of such failure. We compared data from a brief screening assessment on
[Sinusitis in HIV infection]: Acta Otorrinolaringol Esp. 1994 Jul-Aug;45(4):301-2. Unique Identifier : AIDSLINE MED/95000885; Tsi L; Galvez A; Broto J; Garcia Restoy E; Gual J
An alternative view of the Th1/Th2 switch hypothesis in HIV infection.: AIDS Res Hum Retroviruses. 1994 May;10(5):iii-ix. Unique Identifier : AIDSLINE MED/95000921; Romagnani S; Maggi E; Del Prete G; Division of Allergology and Clinical Immunology, Istituto di; Clinica Medica III, University of Florence, Italy.; A theory that seeks to explain what induces the relentless progression of HIV-infected subjects to AIDS has received considerable attention. This theory holds that HIV infection results in a Th1/Th2 switch. However, analysis of constitutive cytokine mRNA expression in lymphoid tissues from HIV-infected individuals did
IgM antibodies directed to HIV: the neglected issue?: AIDS Res Hum Retroviruses. 1994 May;10(5):517-20. Unique Identifier : AIDSLINE MED/95000922; Van de Perre P; Desgranges C; Burny A; AIDS Reference Laboratory, National AIDS Control Programme, Lyon,; France.
Sequence similarities between retroviral proteins and components of the spliceosome [letter]: AIDS Res Hum Retroviruses. 1994 May;10(5):521-2. Unique Identifier : AIDSLINE MED/95000923; Tenenbaum SA; Voss TG; Garry RF; Gallaher WR
Role of HIV-1 Nef expression in activation pathways in CD4+ T cells.: AIDS Res Hum Retroviruses. 1994 May;10(5):523-7. Unique Identifier : AIDSLINE MED/95000924; Carreer R; Groux H; Ameisen JC; Capron A; Centre d'Immunologie et de Biologie Parasitaire, Institut Pasteur; de Lille, France.; The role of the human immunodeficiency virus (HIV-1) Nef protein in T cell activation pathways was investigated using a Jurkat CD4+ cell line stably transfected with a Nef expression vector. Secretion of IL-2 and TNF-alpha, surface expression of IL-2R, and DNA-binding
HIV-1 infection of macrophages promotes long-term survival and sustained release of interleukins 1 alpha and 6.: AIDS Res Hum Retroviruses. 1994 May;10(5):529-39. Unique Identifier : AIDSLINE MED/95000925; Berman MA; Zaldivar F Jr; Imfeld KL; Kenney JS; Sandborg CI; Department of Medicine, California College of Medicine,; University of California, Irvine 92717.; HIV infection of macrophages in vivo may result in activation of monokine genes and cause persistent release of immunomodulatory and inflammatory cytokines. Studies that have examined cytokine (IL-1, IL-6, and TNF-alpha) activation by in vitro infection of normal peripheral blood mononuclear cells (PBMCs) with HIV-1 h
HIV-infected macrophages as efficient stimulator cells for detection of cytotoxic T cell responses to HIV in seronegative and seropositive vaccine recipients.: AIDS Res Hum Retroviruses. 1994 May;10(5):541-9. Unique Identifier : AIDSLINE MED/95000926; McElrath MJ; Hoffman M; Kluckling S; Corey L; Greenberg PD; Department of Medicine, University of Washington, Seattle 98195.; The induction of CD8+ CTL responses is a goal of most HIV-1 vaccine trials, but such potentially protective effector responses have been difficult to evaluate, particularly in these vaccine prevention trials, due to technical obstacles. We report a method to evaluate CTL responses based on the ability to infect autolo
Analysis of cytotoxic T lymphocyte responses to SIV proteins in SIV-infected macaques using antigen-specific stimulation with recombinant vaccinia and fowl poxviruses.: AIDS Res Hum Retroviruses. 1994 May;10(5):551-60. Unique Identifier : AIDSLINE MED/95000927; Kent SJ; Stallard V; Corey L; Hu SL; Morton WR; Gritz L; Panicali DL; Greenberg PD; Department of Medicine, University of Washington, Seattle 98195.; Methods to analyze CD8+ CTL responses to simian immunodeficiency virus (SIV)-encoded proteins are essential to understand lentivirus immunopathogenesis and protective immune responses. Recombinant infectious shuttle vectors are useful for analyzing CTL responses to many viruses, including HIV. Therefore, CTL responses
Genetic analysis of HIV-1 isolates from Brazil reveals presence of two distinct genetic subtypes.: AIDS Res Hum Retroviruses. 1994 May;10(5):561-7. Unique Identifier : AIDSLINE GENBANK/L22088; Louwagie J; Delwart EL; Mullins JI; McCutchan FE; Eddy G; Burke DS; Henry M. Jackson Foundation Research Laboratory, Rockville,; Maryland 20850.; The spread of the human immunodeficiency virus type 1 (HIV-1) is by now virtually worldwide. An understanding of the genetic, biological, and immunological differences among isolates collected in different geographic locales is crucial for the development of globally effective vaccines. Here we report the genetic char
Adhesion mediated by intercellular adhesion molecule 1 attenuates the potency of antibodies that block HIV-1 gp160-dependent syncytium formation.: AIDS Res Hum Retroviruses. 1994 May;10(5):585-93. Unique Identifier : AIDSLINE MED/95000931; Berman PW; Nakamura GR; Department of Immunology, Genentech, Inc., South San Francisco,; California 94080.; Several lines of evidence suggest that leukocyte adhesion molecules can promote HIV-1-mediated cell fusion and syncytium formation. In the present studies, the human kidney cell line, 293, was transfected with the envelope glycoprotein gene of the MN strain of HIV-1 alone or cotransfected with a cDNA encoding intercel
Identification and characterization of the Bel 3 protein of human foamy virus.: AIDS Res Hum Retroviruses. 1994 May;10(5):595-600. Unique Identifier : AIDSLINE MED/95000932; Weissenberger J; Flugel RM; Abteilung Retrovirale Genexpression, Forschungsschwerpunkt; Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.; The human foamy virus (HFV) is a complex retrovirus that contains several regulatory and auxiliary bel genes besides the gag, pol, and env genes. In contrast to the gene products of bel 1 and bel 2/bet that were identified previously, the Bel 3 protein has not been described to date. Here we report the identification
Absence of foamy virus DNA in Graves' disease.: AIDS Res Hum Retroviruses. 1994 May;10(5):601-5. Unique Identifier : AIDSLINE MED/95000933; Schweizer M; Turek R; Reinhardt M; Neumann-Haefelin D; Abteilung Virologie, Universitat Freiburg, Germany.; A report on the high prevalence of foamy virus DNA in lymphocytes from French patients with Graves disease prompted us to investigate a similar cohort of 41 German patients. Using PCR amplification and Southern blot hybridization, we detected foamy virus DNA only in lymphocytes of two accidentally infected humans and
Construction and in vitro properties of SIVmac mutants with deletions in nonessential genes [corrected and republished article originally printed in AIDS Res Hum Retroviruses 1994 Apr;10(4):333-42]: AIDS Res Hum Retroviruses. 1994 May;10(5):607-16. Unique Identifier : AIDSLINE MED/95000934; Gibbs JS; Regier DA; Desrosiers RC; Harvard Medical School, New England Regional Primate Research; Center, Southborough, Massachusetts 01772-9102.; The so-called nonessential genes of primate lentiviruses can be deleted without abrogating the ability of virus to replicate under at least some cell culture conditions. In SIVmac, these genes are vif, vpx, vpr, and nef. Sequences in the upstream region of U3 in the LTR have also been shown to be dispensable for repli
HTLV-I/II seroprevalence in The Gambia: a study of mother-child pairs.: AIDS Res Hum Retroviruses. 1994 May;10(5):617-20. Unique Identifier : AIDSLINE MED/95000935; Del Mistro A; Chotard J; Hall AJ; Fortuin M; Whittle H; De Rossi A; Chieco-Bianchi L; Institute of Oncology, University of Padua, Italy.
Partial envelope sequences from some of the earliest isolates of HIV-1.: AIDS Res Hum Retroviruses. 1994 May;10(5):621-3. Unique Identifier : AIDSLINE GENBANK/L23103; Reitz MS Jr; Popovic M; Saxinger WC; Hall L; Read-Connole E; Markham P; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.
HIV-1 sequence subtype D in the United States.: AIDS Res Hum Retroviruses. 1994 May;10(5):625-7. Unique Identifier : AIDSLINE GENBANK/U08193; Gao F; Yue L; Hill SC; Robertson DL; Graves AH; Saag MS; Shaw GM; Sharp PM; Hahn BH; Department of Medicine, University of Alabama at Birmingham; 35294.
Cross-infection policy [letter; comment]: Br Dent J. 1994 Sep 24;177(6):199. Unique Identifier : AIDSLINE MED/95001030; Hardie J
[With a guitar as medicine (interview by Siv Barstad)]: J Sykepleien. 1993 Nov 30;81(20):22-3. Unique Identifier : AIDSLINE MED/95001074; Halvorsen E
[Because we care]: J Sykepleien. 1993 Dec 14;81(21):30-1. Unique Identifier : AIDSLINE MED/95001092; Barstad S
Physician decision-making in antiretroviral use.: Br J Clin Pract. 1994 Sep-Oct;48(5):243-5. Unique Identifier : AIDSLINE MED/95001247; Valian R; Moyle G; Reddy D; F Hoffmann-La Roche Ltd Biotherapy Group, Basel, Switzerland.; The results of a survey of physicians treating HIV are reported. The survey aimed to determine physicians attitudes to and practices in antiretroviral prescribing and to assess the factors they use for decision-making regarding initiation and change of therapy.
Tuberculosis: current issues in diagnosis and treatment.: Br J Clin Pract. 1994 Sep-Oct;48(5):251-5. Unique Identifier : AIDSLINE MED/95001250; Polkey MI; Rees PJ; Department of Thoracic Medicine, Guy's Hospital, London.; The incidence of tuberculosis began to decline in 1801, which was probably due to improving socioeconomic conditions (certainly not the efforts of the medical profession). Patients cannot be treated unless they are detected, which underlines the importance of notification and case finding. Full multiagent chemotherapy
Cancers not associated with immunodeficiency in HIV infected persons.: Oncology (Huntingt). 1994 Jul;8(7):59-64; discussion 64, 67-8, 70. Unique Identifier : AIDSLINE MED/95001275; Gunthel CJ; Northfelt DW; Department of Medicine, University of California, San Francisco.; Kaposi s sarcoma, non-Hodgkin s lymphoma , and cervical carcinoma are the malignancies most clearly associated with HIV infection. Other malignancies with no established association with immunodeficiency, in particular, lung cancer and germ-cell malignancies, also occur in persons w
The current global situation of the HIV/AIDS pandemic.: Wkly Epidemiol Rec. 1994 Jul 1;69(26):191-2. Unique Identifier : AIDSLINE MED/95001312
Interleukin 1 beta synergises with interleukin 2 in the outgrowth of autologous tumour-reactive CD8+ effectors.: Br J Cancer. 1994 Oct;70(4):625-30. Unique Identifier : AIDSLINE MED/95001345; Baxevanis CN; Dedoussis GV; Gritzapis AD; Stathopoulos GP; Papamichail M; Department of Immunology, Hellenic Anticancer Institute, Athens,; Greece.; Using peritoneal fluid or pleural effusion obtained from 20 patients with lung, ovarian or metastatic breast cancer, we separated tumour cells from malignant effusion-associated mononuclear cells (MEMNCs) using discontinuous Ficoll-Hypaque density gradients. CD3+ T lymphocytes represented the main population of MEMNCs
Epidemiological characteristics of Kaposi's sarcoma prior to the AIDS epidemic.: Br J Cancer. 1994 Oct;70(4):674-6. Unique Identifier : AIDSLINE MED/95001354; Kaldor JM; Coates M; Vettom L; Taylor R; National Centre in HIV Epidemiology and Clinical Research,; Faculty of Medicine, University of New South Wales, Sydney,; Australia.; Twenty-six cases of Kaposi s sarcoma (KS) were recorded by the New South Wales Central Cancer Registry between 1972 and 1982, prior to the first AIDS diagnoses in Australia . The overall annual incidence was 0.47 per million. Incidence was three times higher in males. The highest
Increase in the incidence of non-Hodgkin's lymphomas: evidence for a recent sharp increase in France independent of AIDS.: Br J Cancer. 1994 Oct;70(4):713-5. Unique Identifier : AIDSLINE MED/95001364; Carli PM; Boutron MC; Maynadie M; Bailly F; Caillot D; Petrella T; Registre des Hemopathies Malignes de la Cote d'or (equipe; associee INSERM-DGS), France.; An increasing incidence of non-Hodgkin s lymphoma (NHL) has been reported in several areas of the world and often correlated with the occurrence of AIDS-related lymphomas. A registry specialised in haematopoietic malignancies enabled us to report detailed time trends in the inciden
Trends in primary cerebral lymphoma.: Br J Cancer. 1994 Oct;70(4):716-8. Unique Identifier : AIDSLINE MED/95001365; Lutz JM; Coleman MP; Thames Cancer Registry, Sutton, Surrey, UK.; Primary non-Hodgkin lymphoma of the brain is rare, representing only 1% of all non-Hodgkin lymphomas (NHLs), but its incidence has been increasing rapidly in south-east England since 1985. Among 17,322 cases of NHL registered during the 18 year period 1973-90, there were 210 cases of primary cerebral NHL, of which 179
Treatment of adult T-cell leukaemia-lymphoma with irinotecan hydrochloride (CPT-11). CPT-11 Study Group on Hematological Malignancy.: Br J Cancer. 1994 Oct;70(4):771-4. Unique Identifier : AIDSLINE MED/95001378; Tsuda H; Takatsuki K; Ohno R; Masaoka T; Okada K; Shirakawa S; Ohashi Y; Ota K; Department of Internal Medicine, Kumamoto University Medical; School, Japan.; A late phase II study of a new camptothecin analogue, irinotecan hydrochloride (CPT-11), was conducted to evaluate the anti-tumour effect and toxicity in patients with refractory leukaemia and lymphoma including adult T-cell leukaemia (ATL)-lymphoma, in a multi-institutional cooperative study. All the patients with AT
HIV/AIDS. The changing face of care.: Nurs Stand. 1994 Aug 10-16;8(46):19-21. Unique Identifier : AIDSLINE MED/95001382; Weaver K
The impact of HIV on older people: Part 1.: Nurs Stand. 1994 Aug 10-16;8(46):28-31. Unique Identifier : AIDSLINE MED/95001385; Marr J; The physical and psychological effects of HIV infection in older people have been under-researched. This two-part article draws together the available literature and concludes that HIV has a major impact on older people, which is often different from that experienced by younger people. Next week, the author looks at w
Calls for more AIDS education for midwives as pregnancy infections rise [news]: Nurs Stand. 1994 Aug 10-16;8(46):6. Unique Identifier : AIDSLINE MED/95001398
Disseminated Penicillium marneffei infection with cutaneous lesions in an HIV-positive patient.: Br J Dermatol. 1994 Aug;131(2):280-3. Unique Identifier : AIDSLINE MED/95001439; Liu MT; Wong CK; Fung CP; Department of Dermatology, Veterans General Hospital-Taipei,; Taiwan.; We report the occurrence of disseminated Penicillium marneffei infection with typical skin lesions, in an HIV-positive man. His symptoms resolved, and the skin lesions healed completely, after 2 weeks oral therapy with fluconazole.
Disseminated superficial porokeratosis in a patient with AIDS.: Br J Dermatol. 1994 Aug;131(2):284-9. Unique Identifier : AIDSLINE MED/95001440; Kanitakis J; Misery L; Nicolas JF; Lyonnet S; Chouvet B; Haftek M; Faure M; Claudy A; Thivolet J; Department of Dermatology, Hopital Edouard Herriot, Lyon,; France.; We report the case of a 50-year-old male homosexual suffering from AIDS, who developed diffuse annular hyperkeratotic lesions on the arms and legs. Histopathological examination revealed typical features of porokeratosis, which clinically was of the disseminated superficial type. Ultrastructural examination showed a p
Phenotype and suppressor activity of T-lymphocyte clones extracted from lesions of oral lichen planus.: Br J Dermatol. 1994 Sep;131(3):319-24. Unique Identifier : AIDSLINE MED/95001448; Sugerman PB; Savage NW; Seymour GJ; Department of Dentistry, University of Queensland, St Lucia,; Australia.; Lymphocytes were extracted from six biopsy specimens of oral lichen planus. T-lymphocyte lines were expanded in culture with phytohaemagglutinin and interleukin 2, and cloned by limiting dilution. Fifteen T-cell clones were isolated with a probability of clonality of 96.3%. The majority of clones (n = 13) expressed th
Idiopathic CD4+ lymphocytopenia associated with chronic pruritic papules.: Br J Dermatol. 1994 Sep;131(3):371-5. Unique Identifier : AIDSLINE MED/95001458; Wakeel RA; Urbaniak SJ; Armstrong SS; Sewell HF; Herriot R; Kernohan N; White MI; Department of Dermatology, Aberdeen Royal Hospitals NHS Trust,; U.K.; This is a case report and family study of a 65-year-old man with chronic prurigo lesions, in whom we demonstrated a selective deficiency of circulating T-helper/inducer lymphocytes (CD4+), in the absence of any apparent predisposing disease. He is seronegative for human immunodeficiency virus (HIV types 1 and 2) and h
Impaired ability of bone marrow cells from immunodeficient mice to establish long-term cultures.: Br J Haematol. 1993 Dec;85(4):646-52. Unique Identifier : AIDSLINE MED/95001476; Hamburger AW; Chen RB; Department of Pathology, University of Maryland at Baltimore; 21201.; Haemopoiesis is often depressed in patients suffering from acquired immune deficiency syndrome (AIDS). Although several mechanisms have been postulated to be responsible for depressed haemopoiesis in AIDS patients, the aetiology of this disorder is still unknown. We hypothesized that failure of the stromal microenviro
MGBG: teaching an old drug new tricks.: Ann Oncol. 1994 Jul;5(6):487-93. Unique Identifier : AIDSLINE MED/95001580; Von Hoff DD; Institute for Drug Development, Cancer Therapy and Research; Center, San Antonio, Texas.; Methylglyoxalbisguanylhydrazone or MGBG is an agent with a unique mechanism of action (polyamine biosynthesis inhibition). MGBG was discarded in the 1960s because of severe mucositis and other toxicities. New clinical trials in the late 1970s and early 1980s utilized weekly administration and indicated MGBG had signif
Bilateral abducens nerve lesions in unilateral type 3 Duane's retraction syndrome.: Br J Ophthalmol. 1994 Jul;78(7):588-91. Unique Identifier : AIDSLINE MED/95001757; Mulhern M; Keohane C; O'Connor G; Department of Ophthalmology, Cork Regional Hospital, Wilton,; Ireland.
Bilateral angle closure glaucoma and accelerated cataract formation in a patient with AIDS.: Br J Ophthalmol. 1994 Aug;78(8):656-7. Unique Identifier : AIDSLINE MED/95001777; Joshi N; Constable PH; Margolis TP; Hoyt CS; Leonard TJ; Department of Ophthalmology, Charing Cross Hospital, London.
An orally bioavailable HIV-1 protease inhibitor containing an imidazole-derived peptide bond replacement: crystallographic and pharmacokinetic analysis.: Biochemistry. 1994 Oct 4;33(39):11671-7. Unique Identifier : AIDSLINE MED/95001874; Abdel-Meguid SS; Metcalf BW; Carr TJ; Demarsh P; DesJarlais RL; Fisher S; Green DW; Ivanoff L; Lambert DM; Murthy KH; et al; Department of Macromolecular Sciences, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406.; (2R,4S,5S,1 S)-2-Phenylmethyl-4-hydroxy-5-(tert-butoxycarbonyl) amino-6-phenylhexanoyl-N-(1 -imidazo-2-yl)-2 -methylpropanamide (compound 2) is a tripeptide analogue inhibitor of HIV-1 protease in which a C-terminal imidazole substituent constitutes an isoelectronic, structural mimic of a carboxamide group. Compound 2
1H NMR structure and biological studies of the His23-->Cys mutant nucleocapsid protein of HIV-1 indicate that the conformation of the first zinc finger is critical for virus infectivity.: Biochemistry. 1994 Oct 4;33(39):11707-16. Unique Identifier : AIDSLINE MED/95001879; Demene H; Dong CZ; Ottmann M; Rouyez MC; Jullian N; Morellet N; Mely Y; Darlix JL; Fournie-Zaluski MC; Saragosti S; et al; Departement de Pharmacochimie Moleculaire et Structurale, U266; INSERM-URA D1500 CNRS, Faculte de Pharmacie, Universite Rene; Descartes, Paris, France.; The nucleocapsid protein NCp7 of human immunodeficiency virus type 1 (HIV-1), which has key functions in the virus life cycle, possesses two zinc fingers of the CX2CX4HX4C type characterized by three successive loops containing a tetrahedrally coordinated zinc atom. The replacement of any cysteine by a serine in eithe
Spatial proximity of the HIV-1 nucleocapsid protein zinc fingers investigated by time-resolved fluorescence and fluorescence resonance energy transfer.: Biochemistry. 1994 Oct 11;33(40):12085-91. Unique Identifier : AIDSLINE MED/95001923; Mely Y; Jullian N; Morellet N; De Rocquigny H; Dong CZ; Piemont E; Roques BP; Gerard D; Laboratoire de Biophysique de la Faculte de Pharmacie, CNRS UA; 491, Universite Louis Pasteur, Strasbourg, Illkirch, France.; The three-dimensional structure of peptides encompassing the two zinc-saturated finger motifs of the nucleocapsid protein NCp7 of HIV-1 has been reported by several groups. Whereas the folded structures of the finger motifs were in good agreement, discrepancies existed concerning their spatial relationship since the f
Determination of kinetic rate constants for the binding of inhibitors to HIV-1 protease and for the association and dissociation of active homodimer.: Biochemistry. 1994 Oct 18;33(41):12527-34. Unique Identifier : AIDSLINE MED/95001975; Pargellis CA; Morelock MM; Graham ET; Kinkade P; Pav S; Lubbe K; Lamarre D; Anderson PC; Department of Biochemistry, Boehringer Ingelheim Pharmaceuticals,; Inc., Ridgefield, Connecticut 06877.; Association and dissociation rate constants for a competitive inhibitor of HIV-1 protease were determined by a novel method employing a pair of integrated rate equations. This method, termed the paired progress curve method, is both rapid and reproducible. Progress curves, taken at a single concentration of inhibitor,
[CT-morphologic aspects of the liver in patients with HIV infection]: Aktuelle Radiol. 1994 Jul;4(4):188-91. Unique Identifier : AIDSLINE MED/95002230; Schedel H; Wicht L; Rogler G; Langer R; Felix R; Strahlenklinik und Poliklinik, Universitatsklinikum Rudolf; Virchow, Freie Universitat Berlin.; CT examinations of the liver in HIV-infected patients show more frequent pathological findings. The extended spectrum of differential diagnosis and atypical manifestations of disorders in immunodeficient patients needs to be considered in the interpretation of CT scans. Difficulties in the differential diagnosis of fo
Heterosexual human immunodeficiency virus risk and cocaine use [editorial; comment]: Epidemiology. 1994 Jul;5(4):389-90. Unique Identifier : AIDSLINE MED/95002336; Ostrow DG; Lang JM
Cocaine use and heterosexual exposure to human immunodeficiency virus [see comments]: Epidemiology. 1994 Jul;5(4):398-403. Unique Identifier : AIDSLINE MED/95002338; Larrat EP; Zierler S; Mayer K; Department of Community Health, Brown University School of; Medicine, Providence, RI.; We examined the relation between recent cocaine use and heterosexual exposure to human immunodeficiency virus (HIV). Five hundred nineteen heterosexually active participants in the New England Behavioral Health Study, an HIV testing and counseling program, provided information for this study. The outcome measure inclu
Capture-recapture to estimate the size of the population with human immunodeficiency virus type 1 infection.: Epidemiology. 1994 Jul;5(4):410-4. Unique Identifier : AIDSLINE MED/95002340; Abeni DD; Brancato G; Perucci CA; Epidemiology Unit, Lazio Regional Health Authority, Rome, Italy.; Estimating and monitoring the total number of people infected with human immunodeficiency virus type 1 (HIV-1) is a critical public health objective. No single epidemiologic methodology yields completely reliable estimates. We used techniques originally designed to estimate the size of wildlife populations to compleme
Public/private partnerships in managed care.: J Health Care Poor Underserved. 1994;5(3):185-9; discussion 190-1. Unique Identifier : AIDSLINE MED/95002424; Bredesen P; Office of the Mayor, Nashville, TN 37201.; Although public/private partnerships are often viewed as mechanisms for using private monies to finance public needs, partnerships among health care providers, the business and legal communities, and the public sector offer promise as a way to realign the provision of health care to special-needs communities in the pr
Thalidomide revisited.: Adverse Drug React Toxicol Rev. 1994 Summer;13(2):65-76. Unique Identifier : AIDSLINE MED/95002438; D'Arcy PF; Griffin JP; Queen's University of Belfast.
Short report: time course of clinical response with fluconazole for Candida oesophagitis in patients with AIDS.: Aliment Pharmacol Ther. 1994 Jun;8(3):347-50. Unique Identifier : AIDSLINE MED/95002480; Wilcox CM; Department of Medicine, Emory University School of Medicine,; Atlanta, Georgia 30303.; BACKGROUND: Although fluconazole is increasingly utilized for the therapy of Candida oesophagitis in patients with AIDS, the time course of response has not been adequately defined. METHODS: Over a 48-month period, all HIV-infected patients undergoing upper endoscopy at a large city-county hospital were identified pro
Graft versus host and auto-immune reactions may explain the discontinuity and severity of HIV-1-AIDS disease [editorial]: Biomed Pharmacother. 1994;48(1):1-2. Unique Identifier : AIDSLINE MED/95002651; Mathe G
Pathogenic disorders involved in immunosuppression and T cell depletion characterizing AIDS.: Biomed Pharmacother. 1994;48(1):11-6. Unique Identifier : AIDSLINE MED/95002652; Zagury JF; Lachgar A; Achour A; Chams-Harvey V; Cho YY; Le Coq H; Bizzini B; Feldman M; Burny A; Zagury D; Universite P and M Curie, Laboratorie de Physiologie Cellulaire,; Paris, France.; Four cardinal immune disorders interacting with each other may promote the progressive T cell depletion and immunosuppression characterizing AIDS. Immune activation of HIV-1 infected T4 cells leads to virus release and premature cell death. Both virus release with its resulting viral load and dead cells are the source
Screening of protein sequences databanks by Automat for search of host sequences integration and/or autoimmune disorders induction by retroviruses.: Biomed Pharmacother. 1994;48(1):17-26. Unique Identifier : AIDSLINE MED/95002653; Cantalloube HM; Nahum CE; Zagury JF; ONERA, Chatillon, France.; We have designed an efficient algorithm in order to detect systematically all the oligopeptides shared by a given protein with all the protein sequences in a databank. This software, Automat, also makes statistics on the number of shared oligopeptides. In the present study, we apply Automat on HIV-1 proteins to detect
Detection of CTL activity in PBMCS taken from HIV-ENV immunized individuals after in vitro viral infection.: Biomed Pharmacother. 1994;48(1):7-10. Unique Identifier : AIDSLINE MED/95002657; Achour A; Moukrim Z; Zagury JF; Picard O; Burny A; Zagury D; Universite Pierre et Marie Curie, Paris.; The cellular immune response to the AIDS virus in healthy individuals immunized with HIV-1 antigens has not yet been entirely understood. Unlike HIV-1 infected patients where direct measurements of anti HIV-1 CTL activities can be readily performed with fresh peripheral blood mononuclear cells, uninfected volunteers i
Are HIV-1 seropositive subjects submitted to one of the innumerable AZT randomized double-blind trials, definitively victims of cross and/or common resistance to all virostatics, even in combinations? [editorial]: Biomed Pharmacother. 1994;48(2):49-50. Unique Identifier : AIDSLINE MED/95002659; Mathe G
In vivo eradication of Friend virus as an experimental HIV-model, by combination of zidovudine, acriflavine and an ellipticine analogue. Possible application to the treatment of human pre-AIDS?: Biomed Pharmacother. 1994;48(2):51-3. Unique Identifier : AIDSLINE MED/95002660; Mathe G; Pontiggia P; Bourut C; Chenu E; Orbach-Arbouys S; Institut de Cancerologie et d'Immunologie Hopital Suisse de; Paris, France.; Simultaneous administration of zidovudine, acriflavine and celliptium to Friend virus-injected mice eradicates the virus, as evidenced by the impossibility of the treated-mouse serum, when injected to virgin recipients, to induce spleen foci formation. An adapted preliminary protocol given to patients in whose p 24 an
Inhibitory effect of the oral immune response modifier, bestatin, on cell-mediated and cell-free HIV infection in vitro.: Biomed Pharmacother. 1994;48(2):55-61. Unique Identifier : AIDSLINE MED/95002661; Bourinbaiar AS; Lee-Huang S; Krasinski K; Borkowsky W; Department of Biochemistry, New York University Medical Center,; NY 10016.; The antiviral effect of the immunomodulating anti-cancer agent, bestatin, was examined in vitro by exposing MT-4 lymphocytes to HIV in the presence of 10-fold dilutions of drug (range 100 micrograms-100 pg/ml). The reduction in infectivity was measured by p24 ELISA and compared to the effect of established anti-HIV dr
Clinical use of haematological growth factors in patients with human immunodeficiency virus (HIV-1) infection.: Biomed Pharmacother. 1994;48(2):69-72. Unique Identifier : AIDSLINE MED/95002663; Hermans P; Division of Infectious Diseases, Saint-Pierre University; Hospital, Brussels, Belgium.; HIV-infected patients commonly experience haematological disturbances including anemia, neutropenia or thrombocytopenia. Bone marrow failure may be caused by HIV itself, or by secondary involvement by opportunistic pathogens and malignancy. The need for multiple concomitant suppressive treatments may increase the risk
Involvement of alpha-interferon in HIV-1 induced immunosuppression. A potential target for AIDS prophylaxis and treatment.: Biomed Pharmacother. 1994;48(2):73-7. Unique Identifier : AIDSLINE MED/95002664; Lachgar A; Bizzini B; Laboratoire de Physiologie Cellulaire, Universite Pierre et; Marie Curie, Paris, France.; Since the immune system is impaired in the course of HIV-infection, the purpose of any AIDS vaccine therapy should be the restoration in the patient of an adequate immunocompetence to enable him to respond to the antigenic stimulus represented by the virus. In the present investigation we have shown the antiproliferat
Humoral response in rabbits immunized with calcium phosphate adjuvanted HIV-1 gp160 antigen.: Biomed Pharmacother. 1994;48(2):79-83. Unique Identifier : AIDSLINE MED/95002665; Relyveld E; Chermann JC; Institut Pasteur, Unite des Vaccins Bacteriens,; Marnes-La-Coquette, France.; Rabbits were immunized with either calcium phosphate adjuvanted purified HIV-1 gp160 or a fluid preparation. Circulating antibodies were detected by ELISA, RIPA and Western Blot tests. Sera of rabbits immunized with the adjuvanted preparation contained high levels of anti-gp160 antibodies, as well as antibodies recogn
Antiretroviral therapy for human immunodeficiency virus infection: hope and despair.: Biomed Pharmacother. 1994;48(2):85-8. Unique Identifier : AIDSLINE MED/95002666; Picard O; Service de Medecine Interne, Hopital Saint-Antoine, Paris,; France.; While considering AIDS as an infectious disease with a direct relation between the etiologic agent and the deep immunodeficiency, antiretroviral drugs created much hope. The only transient effect observed with AZT treatment may not be due only to resi
Prevalence of pancreatic disorders in HIV-infected hemophiliacs: diagnostic methods and their clinical significance.: Biomed Pharmacother. 1994;48(2):89-93. Unique Identifier : AIDSLINE MED/95002667; Tradati FC; Gringeri A; Santagostino E; Cultraro D; Simoni L; De Fazio C; Mezzi G; Cappelletti M; Malesci A; Mannucci PM; A Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Ospedale; Maggiore, Milan, Italy.; Pancreatic damage has been well described in HIV+ patients and can occur both for therapy and opportunistic infections, but its prevalence is not clear. The aim of our study was to evaluate the prevalence of pancreatic damage in a cohort of HIV+ hemophiliacs together with the clinical and prognostic value of the diagn
Surveillance of resistance to antituberculosis drugs in developing countries.: Tuber Lung Dis. 1994 Jun;75(3):163-7. Unique Identifier : AIDSLINE MED/95002895; Nunn P; Felten M; Tuberculosis Programme, World Health Organization, Geneva,; Switzerland.; Resistance to antituberculosis drugs is caused by poor management of tuberculosis control. It gives rise to treatment failure, relapse, further transmission of resistant tuberculosis, and multidrug-resistant tuberculosis. Widespread occurrence of multidrug-resistant tuberculosis would constitute a major threat to tube
Tuberculosis in the Republic of Cuba: its possible elimination.: Tuber Lung Dis. 1994 Jun;75(3):188-94. Unique Identifier : AIDSLINE MED/95002900; Gonzalez E; Armas L; Alonso A; Group for Epidemiological Surveillance and Research on Acute; Respiratory Infections and Tuberculosis, Institute Pedro Kouri,; Havana, Cuba.; SETTING: Tuberculosis elimination is a priority in most developed countries, although the AIDS epidemic and drug resistance are a handicap in some of them. Tuberculosis is an even greater problem in developing countries. OBJECTIVE: To evaluate the epidemiological situation in Cuba , t
Influence of HIV status on pathological changes in tuberculous pleuritis.: Tuber Lung Dis. 1994 Jun;75(3):195-8. Unique Identifier : AIDSLINE MED/95002901; Kitinya JN; Richter C; Perenboom R; Chande H; Mtoni IM; Muhimbili Medical Centre, Dar es Salaam, Tanzania.; SETTING: The AIDS epidemic has been associated with an increase in the incidence of tuberculosis, pulmonary or extrapulmonary. OBJECTIVE: To compare morphological changes in tuberculous pleurisy, and response to therapy in HIV-positive and-negative patients. DESIGN: 57 consecutive patients admitted between January and
Recurrence of HIV-related tuberculosis in an endemic area may be due to relapse or reinfection.: Tuber Lung Dis. 1994 Jun;75(3):199-202. Unique Identifier : AIDSLINE MED/95002902; Godfrey-Faussett P; Githui W; Batchelor B; Brindle R; Paul J; Hawken M; Gathua S; Odhiambo J; Ojoo S; Nunn P; et al; Clinical Sciences Department, London School of Hygiene and; Tropical Medicine.; SETTING: Two Research Clinics within Nairobi, Kenya , one in the Infectious Diseases Hospital, the national referral centre for tuberculosis, and one in a community based project in Pumwani district, and the Bacterial Molecular Genetics Unit at the London School of Hygiene and Tropic
In vitro and in vivo synergistic effect of isoniazid with streptomycin and clofazimine against Mycobacterium avium complex (MAC).: Tuber Lung Dis. 1994 Jun;75(3):208-12. Unique Identifier : AIDSLINE MED/95002904; Reddy MV; Srinivasan S; Gangadharam PR; Mycobacteriology Research Laboratory, University of Illinois; College of Medicine at Chicago 60612.; SETTING: Isoniazid (INH), the powerful antituberculosis drug, has also been used in regimens for treating disease caused by Mycobacterium avium complex (MAC), an important opportunistic pathogen encountered in AIDS patients. Its use for treatment of MAC disease has also been endorsed by the American Thoracic Society.
The association of tuberculosis and HIV infection in Harare, Zimbabwe.: Tuber Lung Dis. 1994 Jun;75(3):220-6. Unique Identifier : AIDSLINE MED/95002906; Houston S; Ray S; Mahari M; Neill P; Legg W; Latif AS; Emmanuel J; Bassett M; Pozniak A; Tswana S; et al; University of Zimbabwe School of Medicine, Harare.; SETTING: The tuberculosis (TB) service responsible for all TB treatment in Harare, Zimbabwe . OBJECTIVES: (1) To determine HIV seroprevalence among TB patients and controls. (2) To compare clinical and demographic characteristics of HIV-infected and uninfected TB patients. DESIGN:
Is the incidence of AIDS-associated Mycobacterium avium-intracellulare disease affected by previous exposure to BCG, M. tuberculosis or environmental mycobacteria?: Tuber Lung Dis. 1994 Jun;75(3):234-6. Unique Identifier : AIDSLINE MED/95002908; Grange JM; National Heart and Lung Institute, Royal Brompton Hospital,; London, UK.; The incidence of disease due to Mycobacterium avium-intracellulare (MAI) in AIDS patients varies from region to region. It has been previously postulated that this difference is the result of a protective effect of neonatal BCG vaccination. The basis of this hypothesis is examined and it is further postulated that a s
Reactivation of tuberculosis and leprosy in an HIV-positive case.: Tuber Lung Dis. 1994 Jun;75(3):237-8. Unique Identifier : AIDSLINE MED/95002909; Arora VK; Johri A; Department of Tuberculosis and Chest Diseases, Jawaharlal; Institute of Postgraduate Medical Education and Research,; Pondicherry, India.
Tuberculosis of the vagina in an HIV seropositive case [letter]: Tuber Lung Dis. 1994 Jun;75(3):239-40. Unique Identifier : AIDSLINE MED/95002911; Arora VK; Johri A; Arora R; Rajaram P
Passive hyperimmune plasma therapy in the treatment of acquired immunodeficiency syndrome: results of a 12-month multicenter double-blind controlled trial. The Passive Hyperimmune Therapy Study Group [see comments]: Blood. 1994 Oct 1;84(7):2130-5. Unique Identifier : AIDSLINE MED/95002918; Levy J; Youvan T; Lee ML; HemaCare Corporation, Sherman Oaks, CA 91403.; High-titer anti-human immunodeficiency virus (HIV) antibodies reduced circulating HIV viral burden and has shown promise in previous small uncontrolled studies, warranting a larger controlled study of passive hyperimmune therapy (PHT) in persons with acquired immunodeficiency syndrome (AIDS). The objective of this stu
Lymphocyte depletion during treatment with intensive chemotherapy for cancer.: Blood. 1994 Oct 1;84(7):2221-8. Unique Identifier : AIDSLINE MED/95002932; Mackall CL; Fleisher TA; Brown MR; Magrath IT; Shad AT; Horowitz ME; Wexler LH; Adde MA; McClure LL; Gress RE; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.; Recently we have observed an increased incidence of opportunistic infections in patients treated with intensive chemotherapy for cancer. Because T-cell depletion is associated with similar clinical events in human immunodeficiency virus infection and after bone marrow transplantation, we have analyzed peripheral blood
Administration of an anti-interleukin-6 monoclonal antibody to patients with acquired immunodeficiency syndrome and lymphoma: effect on lymphoma growth and on B clinical symptoms.: Blood. 1994 Oct 15;84(8):2472-9. Unique Identifier : AIDSLINE MED/95002966; Emilie D; Wijdenes J; Gisselbrecht C; Jarrousse B; Billaud E; Blay JY; Gabarre J; Gaillard JP; Brochier J; Raphael M; et al; INSERM U131, Hopital Antoine Beclere, Clamart, France.; Increased interleukin-6 (IL-6) production and expression by malignant cells of the IL-6 receptor has been evidenced in a subgroup of non-Hodgkin s lymphomas, suggesting that this cytokine plays a role in lymphoma growth and in B clinical symptoms. In this study, the effect of the administration of an anti-IL-6 monoclo
Effect of retinoic acid on HL-60 cells infected with human immunodeficiency virus type 1.: Blood. 1994 Oct 15;84(8):2480-8. Unique Identifier : AIDSLINE MED/95002967; Semmel M; Macho A; Coulaud D; Alileche A; Plaisance S; Aguilar J; Jasmin C; Unite 268 INSERM, Villejui, France.; HL-60 cells infected with human immunodeficiency virus type 1 (HIV 1) can be induced to differentiate along the granulocyte pathway by retinoic acid. In these cells, HIV mRNA synthesis is stimulated, but synthesis of viral proteins and virus replication are blocked and HIV-infected cells die after becoming apoptotic a
Stimulation of interleukin-6 production by endothelin in rat bone marrow-derived stromal cells.: Blood. 1994 Oct 15;84(8):2531-8. Unique Identifier : AIDSLINE MED/95002973; Agui T; Xin X; Cai Y; Sakai T; Matsumoto K; Institute for Experimental Animal Science, Nagoya City University; Medical School, Japan.; Endothelin (ET) produced by endothelial cells has recently been found to be a potent vasoconstricting hormone. In this report, ET is shown to be a potent stimulator of interleukin-6 (IL-6) production by rat bone marrow (BM)-derived stromal cells. It was also shown that ET increased the level of mRNA for IL-6 in these
Selective inhibition of human T-lymphotropic virus type I-transformed human T-cell growth by a tax-targeted conditionally cytotoxic recombinant retrovirus.: Blood. 1994 Oct 15;84(8):2591-6. Unique Identifier : AIDSLINE MED/95002979; Fujita M; Murata K; Shiku H; Department of Oncology, Nagasaki University School of Medicine,; Japan.; Adult T-cell leukemia (ATL), a disorder associated with high mortality rates, arises from human T-lymphotropic virus type I (HTLV-I)-infected CD4+ T cells. We designed a retroviral vector-based gene therapy approach to ATL. The long terminal repeat (LTR) of HTLV-I is transactivated by the viral tax protein. We constru
Cytomegalovirus as a co-factor of disease progression in human immunodeficiency virus type 1 infection.: Int J Clin Lab Res. 1994;24(2):86-9. Unique Identifier : AIDSLINE MED/95003082; Nardiello S; Digilio L; Pizzella T; Galanti B; Istituto di Malattie Infecttive, Cattedra di Malattie Tropicali,; Seconda Universita di Napoli, Italy.; Cytomegalovirus has been suggested as a co-factor of disease progression in patients with human immunodeficiency virus type 1 infection. Cytomegalovirus infection is highly prevalent among populations at risk of human immunodeficiency virus 1 infection, and has been associated with both an increased susceptibility to
Serum beta 2-microglobulin in intravenous drug users and its correlation with human immunodeficiency virus infection.: Int J Clin Lab Res. 1994;24(2):90-3. Unique Identifier : AIDSLINE MED/95003083; Chironna M; Fanelli M; Potenza D; Serio G; Quarto M; Institute of Hygiene, University of Bari, Italy.; High levels of serum beta 2-microglobulin have been associated with human immunodeficiency virus infection and beta 2-microglobulin has been used with other serological and immunological markers for monitoring disease progression. The usefulness of beta 2-microglobulin as a prognostic marker during human immunodeficie
[Consciousness and knowledge of AIDS--a survey on nursing school students and age-matched general female students]: Nippon Koshu Eisei Zasshi. 1994 Jul;41(7):658-65. Unique Identifier : AIDSLINE MED/95003128; Satsuta K; Takahashi m; Tate H
Attitudes of seriously ill patients toward treatment that involves high costs and burdens on others [see comments]: J Clin Ethics. 1994 Summer;5(2):109-12. Unique Identifier : AIDSLINE MED/95003131; Schneiderman LJ; Kronick R; Kaplan RM; Anderson JP; Langer RD; Department of Family and Preventive Medicine, University of; California, San Diego.
Characterization of simian immunodeficiency virus (SIV) infected AA-2 cells by SEM and immunoelectron microscopy.: Microsc Res Tech. 1994 Aug 1;28(5):430-9. Unique Identifier : AIDSLINE MED/95003206; Norton WN; Brown CR; Lewis MG; Rippy MK; Martin JE; Zack PM; Southeastern Louisiana University, Hammond 70402.; The ultrastructural features of AA-2 cells infected with either of two strains of simian immunodeficiency virus (SIVMne-E11S or SIVSMM-PBj) were examined by scanning electron microscopy (SEM). Transformed CD4+ human B lymphocytes (AA-2) were inoculated with SIV and observed at 2, 4, and 7 days post-inoculation (dPI).
Update on the management of intestinal cryptosporidiosis in AIDS.: Ann Pharmacother. 1994 Jun;28(6):767-78. Unique Identifier : AIDSLINE MED/95003254; Ritchie DJ; Becker ES; St. Louis College of Pharmacy, MO 63110.; OBJECTIVE: To update readers on the pharmacotherapeutic management of cryptosporidiosis in patients with AIDS. DATA SOURCES: A MEDLINE search was used to identify pertinent literature. Additionally, programs and abstracts from the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy; the 1st Internati
Clarification: controversies in the management of Mycobacterium avium complex infection in AIDS [letter; comment]: Ann Pharmacother. 1994 Jun;28(6):808. Unique Identifier : AIDSLINE MED/95003265; Peloquin CA
Mixed connective tissue disease complicated by infection with human immunodeficiency virus.: Intern Med. 1994 Jun;33(6):342-5. Unique Identifier : AIDSLINE MED/95003313; Ohashi M; Sugihara K; Matsumoto Y; Second Department of Internal Medicine, Nagoya City University; Medical School.; A case of HIV-infection presenting as mixed connective tissue disease (MCTD) is reported. A 26-year-old woman from Kenya was admitted with the symptoms and laboratory findings of MCTD. Her peripheral CD4 cell count was decreased. She had high titers of antibodies to HIV antigen by a
Micturitional disturbance in human T-lymphotropic virus type-1-associated myelopathy.: J Spinal Disord. 1994 Jun;7(3):255-8. Unique Identifier : AIDSLINE MED/95003343; Hattori T; Sakakibara R; Yamanishi T; Yasuda K; Hirayama K; Department of Neurology, School of Medicine, Chiba University,; Japan.; We reported the findings of micturitional histories and urodynamic studies in five patients with human T-lymphotropic virus type-1-associated myelopathy. Histories showed that all patients had obstructive as well as irritative micturitional symptoms, and four of their micturitional symptoms appeared from the onset of
Protein structure--based drug design.: Annu Rev Biophys Biomol Struct. 1994;23:349-75. Unique Identifier : AIDSLINE MED/95003486; Whittle PJ; Blundell TL; Pfizer Central Research, Sandwich, Kent, United Kingdom.; Design cycles will undoubtedly play an increasingly important role in drug discovery in the coming years, as the amount of structural information on protein targets continues to rise. However, the traditional method of drug discovery, based upon random screening and systematic modification of leads by medicinal chemis
Peplau's model of nursing: caring for a man with AIDS.: Br J Nurs. 1994 Apr 28-May 11;3(8):418-22. Unique Identifier : AIDSLINE MED/95003560; Hall K; Nursing models should be seen as an adaptable framework for care. Peplau s model of nursing centres on the interpersonal process and involves the client with a felt need and the nurse who has the knowledge to respond to the problem and be effective within the therapeutic process. When utilised effectively, negative en
Viral infections affecting periodontal health.: Periodontal Clin Investig. 1993 Fall;15(1):17-24. Unique Identifier : AIDSLINE MED/95003569; Porter SR; Mutlu S; Scully CM; Department of Oral Medicine, Pathology and Microbiology, Bristol; Dental Hospital and School, U.K.; A wide spectrum of viruses can give rise to oral and periodontal manifestations. This article reviews viral infections of clinical importance to the periodontologist and confirms the important role of the periodontologist in the recognition and treatment of common viral infections of the mouth.
[Diagnosis and therapy of gastrointestinal Kaposi's sarcoma in AIDS]: Bildgebung. 1994 Apr;61 Suppl 1:46-52. Unique Identifier : AIDSLINE MED/95003600; Zoller WG; Bogner JR; Liess H; Powitz F; Goebel FD; Klinikum Innenstadt, Bereich Gastroenterologie,; Ludwig-Maximilians-Universitat, Munchen.; Gastrointestinal Kaposi s sarcoma (KS) is one of the most frequent neoplastic diseases seen in AIDS. Visceral involvement is associated with shorter survival as compared to cutaneous KS. Our aim was therefore to investigate patients with KS endoscopically. In order to improve the early diagnosis of gastrointestinal KS
Anti-idiotypes and their application under autoimmune, neoplastic, and infectious conditions.: Int Arch Allergy Immunol. 1994 Nov;105(3):211-23. Unique Identifier : AIDSLINE MED/95003750; Shoenfeld Y; Amital H; Ferrone S; Kennedy RC; Department of Medicine B, Sheba Medical Center, Tel Hashomer,; Israel.; Idiotypes and anti-idiotypes are becoming widely used in various experimental applications in multiple fields of research. Administration of anti-idiotypes has been attempted in order to manipulate immune reactions affecting autoimmune, neoplastic, and infectious processes. Immunization with anti-idiotypes and idiotyp
Hematophagic histiocytosis: a clinicopathologic analysis of 23 cases with special reference to the association with peripheral T-cell lymphoma.: J Formos Med Assoc. 1994 May;93(5):421-8. Unique Identifier : AIDSLINE MED/95003826; Chang CS; Wang CH; Su IJ; Chen YC; Shen MC; Department of Internal Medicine, National Taiwan University; Hospital, Taipei, R.O.C.; The clinicopathologic features of 23 patients with hematophagic histiocytosis (HH) are described. All of them exhibited increased histiocytes associated with hemophagocytosis in the marrow. The patients usually presented with fever, hepatosplenomegaly, lymphadenopathy, and cytopenia. The underlying illnesses were hete
Non-spinal psoas abscess due to Mycobacterium tuberculosis in a patient with acquired immunodeficiency syndrome: report of a case.: J Formos Med Assoc. 1994 May;93(5):433-6. Unique Identifier : AIDSLINE MED/95003828; Chen YC; Chang SC; Hsieh WC; Luh KT; Shen MC; Department of Internal Medicine, National Taiwan University; Hospital, Taipei, R.O.C.; Of the 36 patients with human immunodeficiency virus (HIV) infection admitted to our institution since 1985, one had a non-spinal psoas abscess due to Mycobacterium tuberculosis without pulmonary involvement. A 32-year-old male homosexual had prolonged fever and weight loss for two months. Serologic tests for antibodi
French doctors face second trial [news]: BMJ. 1994 Aug 13;309(6952):427. Unique Identifier : AIDSLINE MED/95003877; Dorozynski A
Germany tightens up on blood safety [news]: BMJ. 1994 Aug 13;309(6952):427-8. Unique Identifier : AIDSLINE MED/95003878; Karcher HL
Occurrence of corrugated white patch lesions on lateral border of tongue in lymphoma patients during cytostatic treatment.: Eur J Cancer B Oral Oncol. 1994 May;30B(3):186-90. Unique Identifier : AIDSLINE MED/95003932; Laine PO; Department of Oral and Maxillofacial Surgery, Helsinki University; Central Hospital, Finland.; The question of whether or not there was an association between immunosuppression and occurrence of corrugated white patch lesions on the lateral border of the tongue was studied in 79 patients being treated for non-Hodgkin lymphoma or Hodgkin s disease. The mouths of 55 patients (mean age 47.8 years, 34 males, 21 fem
Value of antifungal prophylaxis with antifungal drugs against oropharyngeal candidiasis in cancer patients.: Eur J Cancer B Oral Oncol. 1994 May;30B(3):196-9. Unique Identifier : AIDSLINE MED/95003934; Meunier F; Paesmans M; Autier P; Institut J. Bordet, Brussels, Belgium.; This report focuses on the value of antifungal prophylaxis with antifungal drugs in preventing oropharyngeal candidiasis. Randomised trials comparing non-AIDS immunocompromised patients receiving or not an oral antifungal agent were reviewed. Colonisation of the throat with Candida albicans is a risk factor, principal
Treatment of refractory T-cell chronic lymphocytic leukemia with purine nucleoside analogues.: Leuk Lymphoma. 1994 Jun;14(1-2):137-9. Unique Identifier : AIDSLINE MED/95003999; Witzig TE; Weitz JJ; Lundberg JH; Tefferi A; Division of Internal Medicine and Hematology, Mayo Clinic,; Rochester, Minnesota 55905.; This report describes two cases of T-cell chronic lymphocytic leukemia (T-CLL) treated with purine nucleoside analogues. One patient had CD8+, CD3+ large granular lymphocytosis (LGL) producing transfusion-dependent anemia and was refractory to chemotherapy. Treatment with four cycles of fludarabine produced a clinical
Increased plasma M-CSF concentration in patients with adult T cell leukemia: clinical correlation.: Leuk Lymphoma. 1994 Jun;14(1-2):151-6. Unique Identifier : AIDSLINE MED/95004002; Yamada Y; Ohmoto Y; Murata K; Tsukasaki K; Momita S; Kamihira S; Atogami S; Sohda H; Moriuchi Y; Itoyama T; et al; Department of Hematology, Nagasaki University School of Medicine,; Japan.; Plasma concentration of M-CSF was measured in 35 patients with adult T cell leukemia (ATL), using a radioimmunoassay (RIA). ATL patients showed elevated levels of plasma M-CSF concentration when compared with healthy adult volunteers. Higher M-CSF levels were observed in acute ATL patients than in patients with chroni
Improved quantitative PCR using nested primers.: PCR Methods Appl. 1994 Jun;3(6):332-7. Unique Identifier : AIDSLINE MED/95004023; Haff LA; Applied Biosystems Division, Perkin-Elmer Corporation, Norwalk,; Connecticut 06859.; Quantitative PCR can often be improved by conducting the amplification with nested primers. First, fewer nonspecific amplification products, which could otherwise interfere with quantitation, are produced. Often, nonspecific products can be eliminated. In these cases, relatively simple nonspecific detection techniques
An internally controlled virion PCR for the measurement of HIV-1 RNA in plasma.: PCR Methods Appl. 1994 Jun;3(6):346-50. Unique Identifier : AIDSLINE MED/95004025; Natarajan V; Plishka RJ; Scott EW; Lane HC; Salzman NP; Department of Microbiology, Georgetown University, Washington,; D.C. 20007.; We have developed an assay to measure the HIV-1 RNA in patients plasma or sera using an infectious mutant virus as an internal control. The mutant virus VX-46 has a 25-bp insert in a conserved region between the primer-binding and major splice donor sites. To utilize this virus as an internal control, different dilut
Nonlinear forecasting of hepatitis and AIDS incidence.: Bull Math Biol. 1994 Sep;56(5):863-73. Unique Identifier : AIDSLINE MED/95004054; Liu WM; Department of Mathematical Sciences, Indiana University,; Indianapolis.; The simplex methods of nonlinear forecasting are used to study the data sets of hepatitis A and AIDS in various regions of the United States . The results are compared with those obtained from the traditional ARIMA methods. In many regions, the simplex methods developed from nonlinear d
Hematologic manifestations of infection with the human immunodeficiency virus.: Rom J Intern Med. 1994 Apr-Jun;32(2):87-118. Unique Identifier : AIDSLINE MED/95004124; Balea M; N. Gh. Lupu Institute of Internal Medicine, Bucharest, Romania.; Selective tropism of human immunodeficiency virus (HIV) for cells with CD4 receptors and especially for TH lymphocytes--key cells in hematopoiesis--has from the clinico-biologic point of view a great many hematologic manifestations of which knowledge is essential for a good diagnosis and treatment as well as for a jud
Reduction of HIV transmission from mother to infant.: Can Commun Dis Rep. 1994 Jun 30;20(12):97-101. Unique Identifier : AIDSLINE MED/95004152
Similarities of psychiatric disorders of AIDS and syphilis: history repeats itself.: Bull Menninger Clin. 1994 Summer;58(3):375-82. Unique Identifier : AIDSLINE MED/95004167; Rosenbaum M; Department of Psychiatry, University of New Mexico School of; Medicine, Albuquerque 87131.; There are marked similarities in the psychiatric disorders associated with autoimmune deficiency syndrome (AIDS) and syphilis (paresis). Although depression is most common, the psychiatric disorders in both conditions include the entire range of clinical syndromes that can simulate any type of mental disorder, functio
Cross-reactive potential of rabbit antibodies raised against a cyclic peptide representing a chimeric V3 loop of HIV-1 gp120 studied by biosensor technique and ELISA.: FEMS Immunol Med Microbiol. 1994 Jun;9(1):77-87. Unique Identifier : AIDSLINE MED/95004283; Richalet-Secordel PM; Deslandres A; Plaue S; You B; Barre-Sinoussi F; Van Regenmortel MH; Immunochemistry Laboratory (UPR 9021, CNRS), Institut de Biologie; Moleculaire et Cellulaire, Strasbourg, France.; Rabbit antibodies were induced against a free cyclic peptide representing the chimeric sequence of a consensus V3 loop of HIV-1 gp120. The reactivity of these antibodies was tested in a biosensor system (BIAcore, Pharmacia AB, Uppsala, Sweden ) and in ELISA with the peptide immunoge
[Rheumatic diseases and immunodeficiency virus infection in Lome (Togo) (letter)]: Rev Rhum Ed Fr. 1994 Feb;61(2):143-4. Unique Identifier : AIDSLINE MED/95004324; Mijiyawa M; Segbena A; Vovor A; Ekouevi K; David M; Amedegnato MD
[Diagnosis of arthritis in black Africa. Apropos of 473 cases in Congo]: Rev Rhum Ed Fr. 1994 Apr;61(4):260-5. Unique Identifier : AIDSLINE MED/95004345; Bileckot R; Ntsiba H; Okongo D; Ognami JB; Service de Rhumatologie et Reeducation Fonctionnelle, CHU de; Brazzaville, Congo.; A cross-sectional study of arthritis was conducted in the Rheumatology Department of the Brazzaville Teaching Hospital, Congo. A total of 473 patients with arthritis seen between 1989 and 1991 were subjected to the limited tests available. Gout was the leading diagnosis (n = 83). Septic arthritis (n = 82) and infectio
[Preliminary screening for antiviral AIDS drugs. IV. Report on fiscal year 1991]: Eisei Shikenjo Hokoku. 1993;(111):100-2. Unique Identifier : AIDSLINE MED/95004484; Kobayashi N; Noguchi Y; Matsuyama M; Akiyoshi K; Noro S; Sato N; Sakurada N; Fujita N; Ishizaki T; Kamimura N; et al; Preliminary screening for antiviral AIDS drugs has been carried out using three different in vitro assay systems. Among 154 samples tested, nine were found to inhibit the growth of HIV in vitro. One of nine has a hopeful sign, as the range of effective doses of the sample is wide.
Will midwives be there for these women?: Midwifery Today Childbirth Educ. 1994 Autumn;(31):19-22, 38. Unique Identifier : AIDSLINE MED/95004834; Edmunds J
Infectious disease markers in autologous and directed donations [see comments]: Transfus Med. 1994 Jun;4(2):135-8. Unique Identifier : AIDSLINE MED/95005128; Pink J; Thomson A; Wylie B; New South Wales Red Cross Blood Transfusion Service, Sydney,; Australia.; Autologous collections are strongly advocated by the New South Wales Red Cross Blood Transfusion Service (BTS) and have increased more than sevenfold since 1988. Directed donations, although not promoted, have also increased during this time. The prevalence of infectious disease markers (HIV, hepatitis C, hepatitis B
[Facing change, a challenge to raise]: Infirm Que. 1994 Sep-Oct;2(1):21-3. Unique Identifier : AIDSLINE MED/95005254; Chabot D
Nothing to fear but fear itself: HIV-infected physicians and the law of informed consent.: J Law Med Ethics. 1994 Summer;22(2):163-75, discussion 176-8. Unique Identifier : AIDSLINE MED/95005274; De Ville KA
Anal intercourse among preadolescent and early adolescent low-income urban African-Americans.: Arch Pediatr Adolesc Med. 1994 Nov;148(11):1201-4. Unique Identifier : AIDSLINE MED/95005314; Stanton B; Li X; Black MM; Ricardo I; Galbraith J; Department of Pediatrics, University of Maryland, Baltimore.; OBJECTIVE: The purpose of this study, which was conducted as part of a larger study on adolescent risk behaviors, was to determine the frequency of anal intercourse among preadolescent and early adolescent youths. DESIGN: Survey. SUBJECTS: Three hundred fifty-one low-income urban African-American youths aged 9 to 15 y
[A scale of attitudes towards AIDS: a psychometric analysis]: Rev Lat Am Enfermagem. 1994 Jul;2(2):37-53. Unique Identifier : AIDSLINE MED/95005483; Moriya TM; Gir E; Hayashida M; The objective of the present methodological study was to construct and validate a scale of attitudes of people concerning AIDS, to aid in the diagnosis of favourable and unfavourable attitudes and evaluation of educational programs related to AIDS. The steps followed to develop the Likert-type scale were: elaboration
Late CD8+ lymphocytic alveolitis after allogeneic bone marrow transplantation and chronic graft-versus-host disease.: Am J Respir Crit Care Med. 1994 Oct;150(4):1056-61. Unique Identifier : AIDSLINE MED/95005648; Leblond V; Zouabi H; Sutton L; Guillon JM; Mayaud CM; Similowski T; Beigelman C; Autran B; Department of Hematology, Pitie-Salpetriere Hospital, Paris,; France.; Late-onset interstitial pneumonitis following allogeneic bone marrow transplantation (BMT) is a rare condition usually caused by a variety of infective agents, although in some cases these are idiopathic. We investigated noninfectious late interstitial pneumonitis with lymphocytic alveolitis in seven allogeneic BMT re
Inflammatory neuropathies associated with known infections (HIV, leprosy, Chagas' disease, Lyme disease).: Baillieres Clin Neurol. 1994 Apr;3(1):149-71. Unique Identifier : AIDSLINE MED/95005811; Said G; Service de Neurologie, Hopital de Bicetre (Universite Paris; XI), France.
[The regional vaccination program in Europe (1991-1993)]: Sante. 1994 May-Jun;4(3):145-50. Unique Identifier : AIDSLINE MED/95005916; Roure C; OMS/EPI, Bureau regional de l'Europe, Copenhague, Danemark.; The European region is passing through a period of rapid transition with the most dramatic changes in the countries of central and eastern Europe (CCEE) and the former USSR. These countries are now facing serious economic problems, a dramatic rise in unemployment and social unrest which has had an impact on the develo
[Routine vaccinations in children and adults infected with HIV]: Sante. 1994 May-Jun;4(3):173-82. Unique Identifier : AIDSLINE MED/95005920; Dabis F; Lepage P; Msellati P; Van de Perre P; Nsengumuremyi F; Hitimana DG; Ladner J; Leroy V; Unite Inserm 330, Universite de Bordeaux II, France.; Five questions were raised in 1986 regarding routine immunization of children infected by the HIV: do vaccines protect these children, both in terms of immunogenicity and clinical efficacy? is immunization, particularly with live attenuated vaccines associated with an increased risk of adverse events? could the stimul
[AIDS and the media (news)]: Sante. 1994 Jul-Aug;4(4):305. Unique Identifier : AIDSLINE MED/95005943; Bloch-Mouillet E; UFR Sante Publique, Universite de Bordeaux-II.
Recent developments in research of HIV infection--a state of art (a review).: Acta Microbiol Immunol Hung. 1994;41(1):5-21. Unique Identifier : AIDSLINE MED/95006107; Fust G; National Institute of Haematology, Blood Transfusion and; Immunology, Budapest, Hungary.
The combined use of soybean agglutinin and immunomagnetic beads for T lymphocyte subset depletion of bone marrow allografts: a laboratory analysis.: J Hematother. 1994 Summer;3(2):111-20. Unique Identifier : AIDSLINE MED/95006296; Preti RA; Farley TJ; Fan Y; Ahmed T; Rose M; Ciavarella D; Hudson Valley Blood Services, Division of the New York Blood; Center, Valhalla 10595.; The prevention of graft-versus-host disease by T-lymphocyte depletion of allografts prior to bone marrow transplantation has resulted in an increase in graft failure/rejection and relapse of disease. Evidence for the selective roles of specific T-lymphocyte subsets in each of the engraftment, graft-versus-host disease
Crystal structure of an extracellular fragment of the rat CD4 receptor containing domains 3 and 4.: Structure. 1994 Jun 15;2(6):469-81. Unique Identifier : AIDSLINE MED/95006315; Lange G; Lewis SJ; Murshudov GN; Dodson GG; Moody PC; Turkenburg JP; Barclay AN; Brady RL; Department of Chemistry, University of York, UK.; BACKGROUND: CD4 is a transmembrane protein on the surface of T lymphocytes that interacts with MHC class II proteins at the surface of accessory cells, and is involved in the triggering of the lymphocytes by foreign antigens. It is also the major receptor for the human immunodeficiency virus. The extracellular portion
Laparotomy in patients infected with human immunodeficiency virus: indications and outcome [see comments]: Br J Surg. 1994 Jul;81(7):942-5. Unique Identifier : AIDSLINE MED/95006378; Lowy AM; Barie PS; Department of Surgery, Cornell University Medical College, New; York.; Four distinct disease processes account for the majority of surgically correctable intra-abdominal pathologies associated with human immunodeficiency virus (HIV) infection: cytomegalovirus infection, Kaposi s sarcoma, non-Hodgkin s lymphoma and
Evaluation of norpeptides as potential inhibitors of HIV-proteases.: Bioorg Med Chem. 1994 Jan;2(1):23-6. Unique Identifier : AIDSLINE MED/95006412; Burgess K; Pal B; Department of Chemistry, Texas A&M University, College Station; 77843.; Peptide mimics of substrates for HIV-proteases were prepared. These norpeptides are identical to a fragment of the HIV-polyprotein except that a crucial scissile bond was deleted, and an alpha,beta-disubstituted amino acid spans the P1 and P1 site. Thus all four stereoisomers of Leu psi[]Ala (i.e. H2NCH(CH2iPr)CH(Me)C
Synthesis of novel inhibitors of the HIV-1 protease: difunctional enols of simple N-protected amino acids.: Bioorg Med Chem. 1994 May;2(5):343-55. Unique Identifier : AIDSLINE MED/95006442; Vaillancourt M; Vanasse B; Le Berre N; Cohen E; Sauve G; Institut Armand-Frappier, Universite du Quebec, Laval, Canada.; A series of enol HIV-1 protease inhibitors which show competitive inhibition and the structure-activity relationship study which led to the design of these compounds are reported. By systematically modifying simple amino acids, Boc-Phe enol and Boc-Tyr enol derivati
Immunologic renal injury.: Curr Opin Nephrol Hypertens. 1993 Mar;2(2):225-30. Unique Identifier : AIDSLINE MED/95006480; Klein JB; University of Louisville School of Medicine, Kidney Disease; Program, KY 40292.; This review summarizes recent progress in the immunologic aspects of parenchymal renal disease. Progress in understanding basic immune mechanisms of glomerular injury is outlined, including the roles of chemoattractants, adhesion molecules, metalloproteinases, and cytokines. Current basic and clinical studies of focal
The spectrum of kidney diseases in patients with human immunodeficiency virus infection.: Curr Opin Nephrol Hypertens. 1993 May;2(3):355-64. Unique Identifier : AIDSLINE MED/95006494; Ortiz-Butcher C; University of Miami School of Medicine, Division of Nephrology,; FL 33101.; Familiarity with renal issues that can challenge the care of patients with human immunodeficiency virus (HIV) should expedite diagnosis and therapeutic interventions. Among the most common problems are electrolyte and acid-base imbalances from many opportunistic infections or their treatments, including hyponatremia,
Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses.: Curr Biol. 1994 Jun 1;4(6):499-505. Unique Identifier : AIDSLINE MED/95006686; Wu Y; Liu Y; Department of Pathology, New York University Medical Center, New; York 10016.; BACKGROUND: CD4+ T-cell help is critical for cytotoxic (CD8+) T-lymphocyte responses to many antigens, such as viruses, minor histocompatibility antigens and allogeneic major histocompatibility antigens. However, the nature of such help is still a mystery: cytokines such as interleukin-2 may be involved but cell-cell
Human immunodeficiency virus infection.: New Horiz. 1993 May;1(2):302-11. Unique Identifier : AIDSLINE MED/95006731; Bartlett JG; Department of Medicine, Johns Hopkins University, School of; Medicine, Baltimore, MD.; Human immunodeficiency virus (HIV) infection is an important topic for virtually all physicians, but it is especially important to those involved in critical care. Recent surveys indicate that about 5% of all hospitalized patients in the United States are infected, although this rate i
Nutritional antioxidants and the modulation of inflammation: theory and practice.: New Horiz. 1994 May;2(2):175-85. Unique Identifier : AIDSLINE MED/95006763; Grimble RF; Institute of Human Nutrition, University of Southampton, UK.; Highly potent substances are produced by the immune system. These substances include cytokines and oxidant molecules, such as hydrogen peroxide, free radicals, and hypochlorous acid. The purpose of immune cell products is to destroy invading organisms and damaged tissue, bringing about recovery. However, oxidants and
Ethical issues involved in the treatment of patients and employment of nurses with acquired immune deficiency syndrome and human immunodeficiency virus infection.: Semin Nurse Manag. 1994 Mar;2(1):32-41. Unique Identifier : AIDSLINE MED/95006997; Craig PA; Tannen MM; Among all health care professionals, nurses have the closest contact with the harsh realities of acquired immune deficiency syndrome (AIDS) and human immunodeficiency syndrome (HIV)-infected patients. Thus, nurses and nurse managers are on the ethical front line when confronted by the thorny issues of treatment of pat
Clinical applications of thymosin alpha-1 [editorial; comment]: Cancer Invest. 1994;12(5):545-7. Unique Identifier : AIDSLINE MED/95007065; Goldstein AL
Immunotherapy in Europe [see comments]: Clin Exp Allergy. 1994 Jun;24(6):515-21. Unique Identifier : AIDSLINE MED/95007128; Malling HJ; Allergy Unit 7511, National University Hospital, Copenhagen,; Denmark.
Management of retinal detachments secondary to cytomegalovirus retinitis.: Can J Ophthalmol. 1994 Jun;29(3):129-33. Unique Identifier : AIDSLINE MED/95007210; Ross WH; Bryan JS; Barloon AS; Department of Ophthalmology, St. Paul's Hospital, Vancouver, BC.; Nine patients with acquired immune deficiency syndrome underwent surgery for rhegmatogenous retinal detachments related to cytomegalovirus ( CMV ) retinitis. The patients were followed for at least 6 months or until death. Two
College policy on reporting HIV-positive physicians discriminatory, OMA says [news]: Can Med Assoc J. 1994 Oct 1;151(7):1002. Unique Identifier : AIDSLINE MED/95007275
HIV/AIDS treatment moves to the small city.: Can Med Assoc J. 1994 Oct 1;151(7):1013-5. Unique Identifier : AIDSLINE MED/95007277; Jeffery AJ; University of Toronto.
AIDS comes to the classroom.: Can Med Assoc J. 1994 Oct 1;151(7):1016-9. Unique Identifier : AIDSLINE MED/95007278; Hamilton J
Blindness in Third World, AIDS among topics as world's ophthalmologists meet in Toronto.: Can Med Assoc J. 1994 Oct 1;151(7):1031-3. Unique Identifier : AIDSLINE MED/95007280; Noble M
Sentinel hospital surveillance of HIV infection in Quebec. Quebec Sentinel Hospital HIV-Seroprevalence Study Group.: Can Med Assoc J. 1994 Oct 1;151(7):975-81. Unique Identifier : AIDSLINE MED/95007300; Alary M; Joly JR; Parent R; Fauvel M; Dionne M; Universite Laval, Centre de recherche, Hopital du; Saint-Sacrement, Quebec.; OBJECTIVE: To measure the HIV seroprevalence rate in a surrogate sample of the general population in the province of Quebec, using a network of sentinel hospitals. DESIGN: Anonymous unlinked sentinel surveillance study. SETTING: Outpatient surgery units in 19 acute care hospitals throughout Quebec. PARTICIPANTS: All p
Use of blood donation history of people with HIV infection to identify recipients at risk [see comments]: Can Med Assoc J. 1994 Oct 15;151(8):1147-51. Unique Identifier : AIDSLINE MED/95007315; Gill MJ; Meyers G; Rajwani A; Department of Medicine, University of Calgary, Alta.; OBJECTIVE: To determine whether previous blood donations from HIV-positive patients posed a threat to recipients. DESIGN: Interviewer-administered questionnaire survey. SETTING: Regional HIV outpatient referral clinic for southern Alberta. PATIENTS: All 478 patients attending the clinic from May 1, 1993, to Mar. 31, 1
Transfusion-associated bacterial sepsis.: Clin Microbiol Rev. 1994 Jul;7(3):290-302. Unique Identifier : AIDSLINE MED/95007436; Wagner SJ; Friedman LI; Dodd RY; Product Development Department, American Red Cross Holland; Laboratory for the Biomedical Sciences, American Red Cross Blood; Services, Rockville, Maryland 20855.; The incidence of sepsis caused by transfusion of bacterially contaminated blood components is similar to or less than that of transfusion-transmitted hepatitis C virus infection, yet significantly exceeds those currently estimated for transfusion-associated human immunodeficiency and hepatitis B viruses. Outcomes are
The medically important aerobic actinomycetes: epidemiology and microbiology.: Clin Microbiol Rev. 1994 Jul;7(3):357-417. Unique Identifier : AIDSLINE MED/95007441; McNeil MM; Brown JM; Emerging Bacterial and Mycotic Diseases Branch, Centers for; Disease Control and Prevention, Atlanta, Georgia 30333.; The aerobic actinomycetes are soil-inhabiting microorganisms that occur worldwide. In 1888, Nocard first recognized the pathogenic potential of this group of microorganisms. Since then, several aerobic actinomycetes have been a major source of interest for the commercial drug industry and have proved to be extremely u
Characterization and augmentation of CD4+ cytotoxic T cell lines against melanoma.: Cancer Immunol Immunother. 1994 Sep;39(3):172-8. Unique Identifier : AIDSLINE MED/95007642; Morisaki T; Morton DL; Uchiyama A; Yuzuki D; Barth A; Hoon DS; John Wayne Cancer Institute at Saint John's Hospital and Health; Center, Santa Monica, CA 90404.; Cytotoxic T cells have been implicated in the control of the progression of human melanoma. Most studies on human tumor T cell immunity have focused on the CD3+CD8+ cytotoxic T lymphocyte (CTL) phenotype; however, CD3+CD4+ CTL are important effector cells in other diseases and may also contribute to antimelanoma immun
Efficacy of Listerine antiseptic against MRSA, Candida albicans and HIV.: Bull Tokyo Dent Coll. 1994 Feb;35(1):23-6. Unique Identifier : AIDSLINE MED/95007917; Yamanaka A; Hirai K; Kato T; Naito Y; Okuda K; Toda S; Okuda K; Department of Microbiology, Tokyo Dental College, Japan.; The antiseptic activity of Listerine and Cool Mint Listerine against methicillin-resistant Staphylococcus aureus (MRSA), Candida albicans, human immuno deficiency virus (HIV) and oral bacteria was examined in this study. Exposure for 30 seconds to Listerine killed MRSA completely. Exposure for 30 seconds significantly
[Effect of acupuncture on T-lymphocyte and its subsets from the peripheral blood of patients with malignant neoplasm]: Chen Tzu Yen Chiu. 1993;18(3):174-7. Unique Identifier : AIDSLINE MED/95008156; Yuan J; Zhou R; School of Medicine of W.C.U.M.S.; Effect of acupuncture on the T-lymphocyte and its subsets from the peripheral blood of patients with malignant neoplasm has been researched in this study. 51 patients were divided into two groups: one in acupuncture treatment and the other without any treatment. 48 healthy adults were also studied as normal control gr
New and emerging infectious diseases: a self-test of clinical recognition.: Cleve Clin J Med. 1994 Jul-Aug;61(4):250-2. Unique Identifier : AIDSLINE MED/95008187; Gordon SM; Department of Infectious Disease, Cleveland Clinic Foundation, OH; 44195.
Medical aspects of pregnancy.: Cleve Clin J Med. 1994 Jul-Aug;61(4):263-71. Unique Identifier : AIDSLINE MED/95008191; Jaff MR; Department of Vascular Medicine, Milwaukee Heart and Vascular; Clinic, WI 53215.; BACKGROUND: Physiologic changes during pregnancy can precipitate or exacerbate potentially serious maternal illnesses that may adversely affect the outcome for both mother and fetus. OBJECTIVE: To review the common medical conditions that may complicate pregnancy. SUMMARY: Venous thromboembolic disease is the most com
HPV and HIV: HPV-DNA identification of colpocytologic smears in HIV positive females through in situ hybridization technique.: Clin Exp Obstet Gynecol. 1994;21(3):160-3. Unique Identifier : AIDSLINE MED/95008246; Zarcone R; Addonizio D; Voto RI; Cardone G; Di Stefano M; Cardone A; Gynaecology and Obstetrics Department, Faculty of Medicine and; Surgery, University of Naples.; Test statistics show a progressive increase of AIDS cases which can be attributed to heterosexual intercourse. Cervicovaginal withdrawals were carried out on 18 HIV positive women for identification of HPV-DNA through In Situ hybridization with three probes 6-11 (A); 16-18 (B); 31-33-51 (C). 61% of patients tested pos
Therapeutic prospects of natural alpha interferon from normal human leucocytes in the treatment of genital condylomata in HIV positive women.: Clin Exp Obstet Gynecol. 1994;21(3):173-6. Unique Identifier : AIDSLINE MED/95008249; Zarcone R; Addonizio D; Voto RI; Cardone G; Di Stefano M; Cardone A; Gynaecology and Obstetrics Department, Faculty of Medicine and; Surgery, University of Naples.; Various Authors underline that HIV positive women have a higher CIN incidence and a higher prevalence of HPV. HIV could act as cofactor in the proliferation of HPV manifestation, because of a hypothetical deficit of local immunity. 5 HIV positive patients have been examined: 3 of them presenting vulvocondylomas and/or
Retroviruses and autoimmune rheumatic diseases.: Clin Exp Immunol. 1994 Oct;98(1):1-5. Unique Identifier : AIDSLINE MED/95008324; Kalden JR; Gay S; Department of Internal Medicine III, University; Erlangen-Nuremberg, Germany.; In autoimmune rheumatic diseases, retroviruses have been repeatedly discussed as important etiologic factors. However, despite a considerable amount of indirect evidence that retroviruses might indeed be involved in triggering or perpetuating autoimmune rheumatic diseases, clear cut direct evidence is still missing. S
Expression patterns of Fc gamma receptors, HLA-DR and selected adhesion molecules on monocytes from normal and HIV-infected individuals.: Clin Exp Immunol. 1994 Oct;98(1):115-22. Unique Identifier : AIDSLINE MED/95008327; Locher C; Vanham G; Kestens L; Kruger M; Ceuppens JL; Vingerhoets J; Gigase P; Department of Tropical Medicine, John A. Burns School of; Medicine, University of Hawaii at Manoa, Honolulu.; The expression and co-expression profiles of functionally important monocyte surface markers were compared between control and HIV+ individuals using combined physical gating and dim CD4 expression to delineate the monocytes. The Fc gamma RII (CD32), the MHC class II antigen HLA-DR and the adhesion molecules CD11a (LF
Envelope glycoprotein (gp120) from HIV-1 enhances Mycobacterium avium growth in human bronchoalveolar macrophages; an effect mediated by enhanced prostaglandin synthesis.: Clin Exp Immunol. 1994 Oct;98(1):123-7. Unique Identifier : AIDSLINE MED/95008329; Denis M; Pulmonary Research Unit, Faculty of Medicine, University of; Sherbrooke, Canada.; Human bronchoalveolar lavage (BAL) macrophages were obtained from normal human volunteers and infected with an AIDS-associated strain of Mycobacterium avium. Infected cells were exposed to purified envelope glycoprotein (gp120) from HIV-1 or to the recombinant non-glycosylated gp120 fragments PBI-RF and PBI-IIIB. Nati
Streptococcal toxic shock-like syndrome: evidence of superantigen activity and its effects on T lymphocyte subsets in vivo.: Clin Exp Immunol. 1994 Oct;98(1):140-4. Unique Identifier : AIDSLINE MED/95008332; Michie C; Scott A; Cheesbrough J; Beverley P; Pasvol G; Department of Paediatrics and Neonatal Medicine, Hammersmith; Hospital, London, UK.; Toxic shock-like syndrome is a serious complication of invasive streptococcal disease. The syndrome is believed to be the consequence of exposure to exotoxins produced by the infecting organisms which behave as superantigens. We describe two patients who fulfilled clinical criteria for this syndrome, one of whom died.
Different growth factor requirements for human Th2 cells may reflect in vivo induced anergy.: Clin Exp Immunol. 1994 Oct;98(1):151-7. Unique Identifier : AIDSLINE MED/95008334; Van Reijsen FC; Wijburg OL; Gebhardt M; Van Ieperen-Van Dijk AG; Betz S; Poellabauer EM; Thepen T; Bruijnzeel-Koomen CA; Mudde GC; Department of Dermatology/Allergology, University Hospital,; Utrecht, The Netherlands.; We previously reported the isolation of allergen-specific Th2 lines and clones from atopy patch test (APT) sites of atopic dermatitis (AD) patients. Upon stimulation with allergen or anti-CD3+ phorbol myristate acetate (PMA) IL-4 was released with or without IL-5, while no (or extremely low concentrations of)
The development of transplant coronary artery disease after cardiac transplantation is correlated with a predominance of CD8+ T lymphocytes in endomyocardial biopsy derived T cell cultures.: Clin Exp Immunol. 1994 Oct;98(1):158-62. Unique Identifier : AIDSLINE MED/95008335; Jutte NH; Groeneveld K; Balk AH; Ouwehand AJ; Loonen EH; Van der Linden M; Strikwerda S; Mochtar B; Claas FH; Weimar W; Department of Internal Medicine I, Erasmus University/University; Hospital Dijkzigt, Rotterdam, The Netherlands.; Long-term survival of heart transplant recipients is limited by the development of transplant coronary artery disease (TCAD). We analysed whether the development of TCAD is correlated with the incidence of acute rejection episodes, with the formation of anti-HLA antibodies or with the composition and function of T lym
Establishment of nickel-specific T cell lines from patients with allergic contact dermatitis: comparison of different protocols.: Clin Immunol Immunopathol. 1994 Oct;73(1):142-5. Unique Identifier : AIDSLINE MED/95008375; Bour H; Nicolas JF; Garrigue JL; Demidem A; Schmitt D; INSERM U346, Hopital Edouard Herriot, Lyon, France.; Allergic contact dermatitis is a delayed-type hypersensitivity reaction, secondary to hapten-specific T lymphocyte activation in sensitized individuals. The present study reports on the establishment of T cell lines from peripheral blood mononuclear cells (PBMC) of nickel-allergic patients, initially cultured with nic
Herpes simplex virus type 1 pathogenicity in mice expressed by lytic infection in pre-B and B cells.: Clin Immunol Immunopathol. 1994 Oct;73(1):38-44. Unique Identifier : AIDSLINE MED/95008380; Lamontagne L; Jolicoeur P; Departement des Sciences Biologiques, Universite du Quebec a; Montreal, Canada.; The outcome of herpes simplex virus type 1 (HSV-1) infection in human or in the murine model can be influenced by host immunocompetency. We postulate in this work that HSV-1 infection alters bone marrow B lymphopoiesis in genetically determined susceptible mice. To verify this hypothesis, resistant C57BL/6 or suscepti
Experimental Chagas' disease: electrophysiology and cell composition of the neuromyopathic inflammatory lesions in mice infected with a myotropic and a pantropic strain of Trypanosoma cruzi.: Clin Immunol Immunopathol. 1994 Oct;73(1):69-79. Unique Identifier : AIDSLINE MED/95008384; Mirkin GA; Jones M; Sanz OP; Rey R; Sica RE; Gonzalez Cappa SM; Departamento de Microbiologia, Facultad de Medicina, Universidad; de Buenos Aires, Argentina.; C3H/HeN mice infected with the pantropic/reticulotropic Trypanosoma cruzi RA strain disclosed electromyographic signs (EMG) of neuropathic damage, while those infected with the myotropic CA-I strain showed EMG suggestive of primary muscle involvement. Although both strains induced inflammatory infiltrates in hamstring
Effect of zidovudine therapy on CD8+ T cell anti-HIV activity.: Clin Immunol Immunopathol. 1994 Oct;73(1):80-7. Unique Identifier : AIDSLINE MED/95008385; Mackewicz CE; Landay A; Hollander H; Levy JA; University of California, School of Medicine, San Francisco; 94143-0128.; CD8+ T cell suppression of HIV replication in vitro was evaluated over 1-2 years in 12 HIV-infected individuals receiving daily dosages of Zidovudine ( AZT ) and in 9 untreated subjects. In the 12 AZT-treated patients, the level of CD8+ cell antiviral a
IL-2-dependent HTLV-I-infected T cells escape from non-specific, MHC-unrestricted cellular cytotoxicity.: Clin Immunol Immunopathol. 1994 Nov;73(2):205-14. Unique Identifier : AIDSLINE MED/95008393; Plotnicky H; Cyblat D; Vernant JC; Desgranges C; Unite de Recherche sur les Hepatites, SIDA et Retrovirus; Humains, INSERM U271, Lyon, France.; The susceptibility of NK cell-mediated cytolysis was compared between 5 human HTLV-I-transformed T cell lines and 10 newly established IL-2-dependent HTLV-I-infected lines. None of the cell lines were killed after 4 hr incubation with normal PBMC. However, after 20 hr, 3 HTLV-I-transformed lines were significantly lys
Distribution and antigenic analysis of circulating F(ab')2-reactive IgG in patients with HIV-1 infection.: Clin Immunol Immunopathol. 1994 Nov;73(2):229-34. Unique Identifier : AIDSLINE MED/95008396; Silvestris F; Di Loreto M; Romito A; Grizzuti MA; Dammacco F; Department of Biomedical Sciences and Human Oncology, University; of Bari Medical School, Italy.; Serum titers and molecular specificity of anti-F(ab )2 antibodies were investigated in human immunodeficiency virus type 1 (HIV-1) infection with respect to their supposed cytopenic role on CD4+ cells. The levels of antibodies to F(ab )2 fragment and to HIV-1 glycoprotein epitopes were measured by immunoenzymatic meth
A distinctive form of soluble CD8 is secreted by stimulated CD8+ cells in HIV-1-infected and high-risk individuals.: Clin Immunol Immunopathol. 1994 Nov;73(2):252-60. Unique Identifier : AIDSLINE MED/95008399; Schlesinger M; Chu FN; Badamchian M; Jiang JD; Roboz JP; Goldstein AL; Bekesi JG; Hubert H. Humphrey Center for Experimental Medicine and Cancer; Research, Hebrew University, Hadassah Medical School, Jerusalem,; Israel.; The aim of the present study was to investigate the biochemical structure and pathogenic significance of the soluble CD8 (sCD8) present in the serum of HIV-1-infected individuals. In a longitudinal study of a cohort of HIV-infected homosexuals and the amount of sCD8 detected in the plasma was correlated with changes i
Renal alterations induced by sulfadiazine therapy in an AIDS patients [letter; comment]: Clin Nephrol. 1994 Jul;42(1):68-9. Unique Identifier : AIDSLINE MED/95008441; Marques LP; Madeira EP; Santos OR
[Migrating radiculopathy--an unusual complication of systemic lupus erythematosus in an HTLV-1 carrier]: Rinsho Shinkeigaku. 1994 May;34(5):466-9. Unique Identifier : AIDSLINE MED/95008531; Kondo T; Matsui M; Department of Neurology, Wakayama Redcross Hospital.; We reported a 54-year-old HTLV-I seropositive female patient with systemic lupus erythematosus (SLE), who developed migrating radiculopathy but without chronic progressive myelopathy. She occasionally noticed butterfly rash and photosensitivity of the skin as well as painful episodes in different joints for 10 years.
Pharmacokinetic interaction between zidovudine and valproic acid in patients infected with human immunodeficiency virus.: Clin Pharmacol Ther. 1994 Sep;56(3):272-8. Unique Identifier : AIDSLINE MED/95008594; Lertora JJ; Rege AB; Greenspan DL; Akula S; George WJ; Hyslop NE Jr; Agrawal KC; Department of Pharmacology, Tulane University School of Medicine,; New Orleans, LA 70112.; Zidovudine is metabolized to an inactive 5 -glucuronide and has a short plasma half-life requiring frequent dosing. The present study in six patients without symptoms who were infected with human immunodeficiency virus was undertaken to determine if coadministration of valproic acid which, like zidovudine, is metaboli
Molecular biology of HIV.: Clin Lab Med. 1994 Jun;14(2):203-20. Unique Identifier : AIDSLINE MED/95008662; Trono D; Infectious Disease Laboratory, Salk Institute, La Jolla,; California.; This article reviews the molecular events involved in HIV replication. A special emphasis is placed on aspects most relevant to AIDS pathogenesis and on recent discoveries.
HIV-induced T-lymphocyte depletion.: Clin Lab Med. 1994 Jun;14(2):221-38. Unique Identifier : AIDSLINE MED/95008663; Schattner E; Laurence J; Department of Medicine, New York Hospital-Cornell Medical Center,; New York.; A fundamental paradox of HIV disease is the progressive diminution in CD4+ lymphocytes despite the fact that only a small fraction of cells are infected. The mechanisms of T-cell depletion in HIV disease are divers. These include immune and autoimmune destruction of infected and uninfected cells, signaling derangement
Cellular latency in HIV-1 infection.: Clin Lab Med. 1994 Jun;14(2):239-55. Unique Identifier : AIDSLINE MED/95008664; Laughlin MA; Pomerantz RJ; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania.; There are multiple levels of transcriptional regulation that a cell can bring to bear on either native cellular genes or integrated proviral genes. One such level of regulation is inducible sequence-specific transcriptional factors, such as NF-kappa B, which have been extensively investigated with respect to the HIV-1
HIV-1 antibodies and serology.: Clin Lab Med. 1994 Jun;14(2):257-69. Unique Identifier : AIDSLINE MED/95008665; Farzadegan H; School of Hygiene and Public Health, Johns Hopkins University,; Baltimore, Maryland.; This article reviews various laboratory assays for screening and detection of antibodies against HIV-1 and viral components. The prognostic role of these assays in the course of HIV-1 infection is described as well as functional aspects of anti-HIV antibodies.
The cytotoxic T-lymphocyte response in HIV-1 infection.: Clin Lab Med. 1994 Jun;14(2):271-99. Unique Identifier : AIDSLINE MED/95008666; Kalams SA; Walker BD; Massachusetts General Hospital Infectious Disease Unit, Boston.; HIV infection is associated with an extremely vigorous virus-specific cytotoxic T-lymphocyte (CTL) response. This CTL activity is of sufficient magnitude to be detected using freshly isolated peripheral blood mononuclear cells, but despite this vigorous immune response, HIV-1 disease ultimately progresses. This articl
HIV-1 burden as a marker of disease progression and clinical response to therapy in AIDS.: Clin Lab Med. 1994 Jun;14(2):301-11. Unique Identifier : AIDSLINE MED/95008667; Coombs RW; Department of Laboratory Medicine, University of Washington,; Seattle.; In summary, much still needs to be learned about the pathogenetic significance of changes in virus load and importantly, the clinical significance of therapy-induced changes in virus load. The failure of current therapeutic regimens to effect a substantive and durable change in virus load is not a failure of the virol
Polymerase chain reaction and HIV.: Clin Lab Med. 1994 Jun;14(2):313-33. Unique Identifier : AIDSLINE MED/95008668; Ferre F; Immune Response Corporation, Carlsbad, California.; In this article, the synergistic progress for both polymerase chain reaction (PCR) technology and HIV-1 is reviewed. The latest developments in standard PCR technology for the detection and quantitation of HIV-1 DNA molecules are summarized. In addition, examples of applications selected from the fields of HIV-1 diagn
In situ polymerase chain reaction and HIV-1.: Clin Lab Med. 1994 Jun;14(2):351-65. Unique Identifier : AIDSLINE MED/95008670; Bagasra O; Pomerantz RJ; Department of Medicine, Jefferson Medical College, Thomas; Jefferson University, Philadelphia, Pennsylvania.; The study of low-copy viral or genomic DNA sequences by in situ hybridization is often limited by sensitivity. The ability to detect a single copy of a specific gene in situ has many advantages and multiple applications in molecular biology, pathology, and cell biology. One of the limitations of in situ hybridization,
Use of acridinium-ester-labeled DNA probes for identification of mycobacteria in Bactec 13A blood cultures.: Diagn Microbiol Infect Dis. 1994 Mar;18(3):137-9. Unique Identifier : AIDSLINE MED/95008680; Ephraim DA; Spitzer ED; Department of Laboratories, University Hospital, Stony Brook, New; York.; AccuProbe tests for mycobacteria (Gen-Probe) cannot be performed directly on Bactec 13A cultures because of interfering substances. This problem can be circumvented by subculturing to Bactec 12B media. Artifactual chemiluminescence greater than the positive cutoff was seen in 15 of 19 13A cultures containing Mycobacte
In vitro susceptibility of clinical isolates of Mycobacterium avium and M. intracellulare to folate antagonists.: Diagn Microbiol Infect Dis. 1994 Mar;18(3):201-4. Unique Identifier : AIDSLINE MED/95008691; Raszka WV Jr; Skillman LP; McEvoy PL; Department of Pediatrics, Walter Reed Army Medical Center,; Washington, DC.; An agar dilution method against trimethoprim, sulfamethoxazole, sulfisoxazole, and trimethoprim-sulfamethoxazole was used to test clinical isolates of Mycobacterium intracellulare (MI) and M. avium (MA) from both HIV-infected and non-infected patients. MI and MA isolates demonstrated similar susceptibility data and we
Guidelines for preventing dilution false negatives in in vitro laboratory testing of the donor population [see comments]: Cornea. 1994 Jul;13(4):290-3. Unique Identifier : AIDSLINE MED/95008806; Heck EL; Baxter CR; Transplant Services Center, University of Texas Southwestern; Medical Center, Dallas 75235.; In this article we develop a calculation or formula for use in determining the potential dilution effect of fluids administered during patient treatment on serologic testing parameters. The formula uses basic principles of (a) fluid distribution over time from administration; (b) ratios of plasma and extravascular flu
Survey of simian immunodeficiency virus among nonhuman primate populations.: Curr Top Microbiol Immunol. 1994;188:1-20. Unique Identifier : AIDSLINE MED/95008908; Hayami M; Ido E; Miura T; Research Center for Immunodeficiency Virus, Kyoto University,; Japan.
Mucosal transmission of simian immunodeficiency virus.: Curr Top Microbiol Immunol. 1994;188:107-22. Unique Identifier : AIDSLINE MED/95008909; Miller CJ; California Regional Primate Research Center, University of; California Davis 95616.
Comparison of regulatory features among primate lentiviruses.: Curr Top Microbiol Immunol. 1994;188:123-44. Unique Identifier : AIDSLINE GENBANK/X15781; Jeang KT; Gatignol A; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, MD 20892.
MHC of nonhuman primates.: Curr Top Microbiol Immunol. 1994;188:145-59. Unique Identifier : AIDSLINE MED/95008911; Watkins DI; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53715-1299.
CD4+ T cell responses to simian immunodeficiency virus.: Curr Top Microbiol Immunol. 1994;188:161-73. Unique Identifier : AIDSLINE MED/95008912; Mills KH; Jones WC; Immunobiology Department, National Institute for Biological; Standards and Control, South Mimms, Potters Bar, Herts, UK.
The SIVmac specific cytotoxic T lymphocyte response in the acutely infected rhesus monkey.: Curr Top Microbiol Immunol. 1994;188:175-84. Unique Identifier : AIDSLINE MED/95008913; Letvin NL; Reimann KA; Yasutomi Y; Ringler DJ; Yamamoto H; Harvard Medical School, New England Regional Primate Research; Center, Southborough, MA 01772-9102.
Simian immunodeficiency viruses of African green monkeys.: Curr Top Microbiol Immunol. 1994;188:21-33. Unique Identifier : AIDSLINE MED/95008915; Kurth R; Norley S; Paul-Ehrlich-Institute, Langen, Germany.
Towards a vaccine against AIDS: lessons from simian immunodeficiency virus vaccines.: Curr Top Microbiol Immunol. 1994;188:221-37. Unique Identifier : AIDSLINE MED/95008916; Stott EJ; National Institute for Biological Standards and Control, South; Mimms, Potters Bar, Hertfordshire, UK.
Pathology of simian immunodeficiency virus induced disease.: Curr Top Microbiol Immunol. 1994;188:35-64. Unique Identifier : AIDSLINE MED/95008917; Lackner AA; California Regional Primate Research Center, University of; California, Davis 95616.
SIVsmmPBj14: an atypical lentivirus.: Curr Top Microbiol Immunol. 1994;188:65-76. Unique Identifier : AIDSLINE MED/95008918; Fultz PN; Department of Microbiology, University of Alabama at Birmingham; 35294.; SIV-PBj14 is atypical for a lentivirus in that infection of pig-tailed macaques usually does not result in long-term progressive disease; however, this model may potentially provide valuable information about the pathogenesis of HIV and the development of AIDS. By capitalizing on some of the unique properties of the v
Conserved framework of envelope glycoproteins among lentiviruses.: Curr Top Microbiol Immunol. 1994;188:77-105. Unique Identifier : AIDSLINE MED/95008919; Pancino G; Ellerbrok H; Sitbon M; Sonigo P; Genetique des virus (CNRS UPR0415), Institut Cochin de; Genetique Moleculaire, Paris, France.
Cytotoxic T lymphocyte responses against measles virus.: Curr Top Microbiol Immunol. 1994;189:151-67. Unique Identifier : AIDSLINE MED/95008923; UytdeHaag FG; van Binnendijk RS; Kenter MJ; Osterhaus AD; Department of Virology, Erasmus University Rotterdam, The; Netherlands.
Cytotoxic T lymphocytes in humans exposed to Plasmodium falciparum by immunization or natural exposure.: Curr Top Microbiol Immunol. 1994;189:187-203. Unique Identifier : AIDSLINE MED/95008925; Hoffman SL; Sedegah M; Malik A; Malaria Program, Naval Medical Research Institute, Bethesda, MD; 20889-5607.
Cytotoxic T lymphocytes in human immunodeficiency virus infection: regulator genes.: Curr Top Microbiol Immunol. 1994;189:65-74. Unique Identifier : AIDSLINE MED/95008927; Riviere Y; Robertson MN; Buseyne F; Unite de Virologie et Immunologie Cellulaire, Institut Pasteur,; Paris, France.
Therapeutic reconstitution of human viral immunity by adoptive transfer of cytotoxic T lymphocyte clones.: Curr Top Microbiol Immunol. 1994;189:9-34. Unique Identifier : AIDSLINE MED/95008929; Riddell SR; Greenberg PD; Fred Hutchinson Cancer Research Center, Seattle, WA.
Cytotoxic T lymphocytes in dengue virus infection.: Curr Top Microbiol Immunol. 1994;189:93-108. Unique Identifier : AIDSLINE MED/95008930; Kurane I; Ennis FA; Department of Medicine, University of Massachusetts Medical; Center, Worcester 01655.
Generalized air cysts complicated by fatal bilateral pneumothoraces in a patient with AIDS-related Pneumocystis carinii pneumonia.: Chest. 1994 Oct;106(4):1271-2. Unique Identifier : AIDSLINE MED/95009005; Lazard T; Guidet B; Meynard JL; Capron F; Offenstadt G; Service de Reanimation Polyvalente, Hopital Saint-Antoine,; Paris, France.; We describe a case of air cyst lesions in an AIDS patient suffering from Pneumocystis carinii pneumonia. This case is unique because these lesions were generalized to both lungs and initially well tolerated. Pathologic examination revealed extensive tissue invasion by P carinii. The prognosis was complicated by bilate
Tamponade due to Rhodococcus equi in acquired immunodeficiency syndrome.: Chest. 1994 Oct;106(4):1278-9. Unique Identifier : AIDSLINE MED/95009009; Legras A; Lemmens B; Dequin PF; Cattier B; Besnier JM; Service de Renimation Medicale, Laboratoire de Microbiologie,; Hopital Bretonneau, France.; Infection with Rhodococcus equi has been described as a cause of cavitary pneumonia in AIDS patients. We report such a case, complicated by bacteremia, tamponade, and possible brain and liver abscesses. Medical treatment was successful with pericardiocentesis and antibiotherapy with teicoplanin, gentamicin, clarithrom
Cardiac tamponade due to primary pericardial lymphoma in a patient with AIDS.: Chest. 1994 Oct;106(4):1295-9. Unique Identifier : AIDSLINE MED/95009018; Aboulafia DM; Bush R; Picozzi VJ; Section of Hematology and Oncology, University of Washington,; Seattle.; Cardiac tamponade due to lymphomatous involvement of the heart is a dramatic and unusual complication. Because of their nonspecific clinical presentation, these tumors are seldom diagnosed antemortem. We report the case of a patient with AIDS who presented with signs and symptoms of cardiac tamponade. Emergency perica
The Fourth China National Congress on Medical Virology.: Chin Med J (Engl). 1994 May;107(5):391-4. Unique Identifier : AIDSLINE MED/95009087; Qiu FX; Duan SX; Institute of Epidemiology and Microbiology, Chinese Academy of; Preventive Medicine, Beijing.
Structure of the Drosophila HeT-A transposon: a retrotransposon-like element forming telomeres.: Chromosoma. 1994 Jun;103(3):215-24. Unique Identifier : AIDSLINE GENBANK/U06947; Danilevskaya O; Slot F; Pavlova M; Pardue ML; Department of Biology, Massachusetts Institute of Technology,; Cambridge 02139.; Telomeres of Drosophila appear to be very different from those of other organisms. A transposable element, HeT-A, plays a major role in forming telomeres and may be the sole structural element, since telomerase-generated repeats are not found. HeT-A transposes only to chromosome ends. It appears to be a retrotransposo
Malabsorption and deficiency of vitamin B12 in HIV-infected patients with chronic diarrhea.: Dig Dis Sci. 1994 Oct;39(10):2159-62. Unique Identifier : AIDSLINE MED/95009243; Ehrenpreis ED; Carlson SJ; Boorstein HL; Craig RM; Department of Gastroenterology, Cleveland Clinic Florida, Ft.; Lauderdale 33309.; Deficiency of vitamin B12 is commonly reported in HIV-infected patients. We measured vitamin B12 levels in 36 HIV-infected patients with chronic diarrhea (> 3 stools/day for six weeks or more). Eight patients had an identifiable cause of diarrhea. Vitamin B12 levels were low in 39%. Sixteen of these patients were sele
Association of lipid accumulation in small intestinal mucosa with decreased serum triglyceride and cholesterol levels in AIDS.: Dig Dis Sci. 1994 Oct;39(10):2163-9. Unique Identifier : AIDSLINE MED/95009244; Benhamou Y; Hilmarsdottir I; Desportes-Livage I; Hoang C; Datry A; Danis M; Gentilini M; Opolon P; Departement des Maladies Infectieuses, Parasitaires, Tropicales; et de Sante Publique, Groupe Hospitalier Pitie-Salpetriere,; Paris, France.; Lipid accumulation has been described in the duodenal lamina propria of human immunodeficiency virus (HIV)-infected patients with diarrhea and malabsorption. Using light and electron microscopy, we studied duodenal biopsies obtained from 54 consecutive HIV-infected patients by means of upper gastrointestinal endoscopy
[Zidovudine for asymptomatic HIV patients?]: Dtsch Med Wochenschr. 1994 Oct 7;119(40):1374-5. Unique Identifier : AIDSLINE MED/95009467; Flepp M; Departement fur Innere Medizin Universitatsspital, Zurich.
Knowledge of sexually transmitted diseases, HIV infection and AIDS among sexually active adolescents in Nairobi, Kenya and its relationship to their sexual behaviour and contraception.: East Afr Med J. 1994 Feb;71(2):122-8. Unique Identifier : AIDSLINE MED/95009594; Lema VM; Hassan MA; Department of Obstetrics and Gynaecology, College of Medicine,; University of Malawi, Blantyre.; A total of 675 male and female adolescents, aged 10 to 19 years, who were attending the adolescent antenatal clinic at the Kenyatta National Hospital and the Special STD and Skin Disease Clinic in Nairobi, between April 1, 1991 and July 31, 1991, were interviewed by means of partially structured questionnaire, to dete
Antimicrobial susceptibility and presence of extrachromosomal deoxyribonucleic acid in Salmonella and Shigella isolates from patients with AIDS.: East Afr Med J. 1994 May;71(5):292-6. Unique Identifier : AIDSLINE MED/95009612; Kariuki S; Gilks C; Brindle R; Batchelor B; Kimari J; Waiyaki P; Centre for Microbiology Research, Kenya Medical Research; Institute (KEMRI), Nairobi.; The development of multi-drug resistance by enteric bacteria is an increasing problem in the developing countries. There is need to monitor antimicrobial susceptibility of these organisms in order to ensure appropriate treatment and control of infections. Antimicrobial susceptibility patterns, plasmid DNA content and
Knowledge, practices and attitudes towards HIV positive and AIDS patients among dental auxiliaries.: East Afr Med J. 1994 May;71(5):304-10. Unique Identifier : AIDSLINE MED/95009615; Kaimenyi JT; Ndung'u FL; Department of Dental Surgery, College of Health Sciences,; University of Nairobi.; The purpose of this study was to assess knowledge, practices and attitudes towards HIV positive and AIDS patients amongst 71 dental auxiliaries using on a self administered questionnaire. 65 (91.5%) returned the questionnaire. In general, respondents knowledge was fair. 87.7% felt that dentistry as practised in
Cryptosporidiosis in HIV positive patients at Kenyatta National Hospital, Nairobi, Kenya [letter]: East Afr Med J. 1994 May;71(5):334-5. Unique Identifier : AIDSLINE MED/95009623; Mirza NB; Bhatt KM; Bhatt SM; Kanja C
Gypsy transposition correlates with the production of a retroviral envelope-like protein under the tissue-specific control of the Drosophila flamenco gene.: EMBO J. 1994 Sep 15;13(18):4401-11. Unique Identifier : AIDSLINE MED/95009941; Pelisson A; Song SU; Prud'homme N; Smith PA; Bucheton A; Corces VG; Centre de Genetique Moleculaire, CNRS, Gif sur Yvette, France.; Gypsy displays striking similarities to vertebrate retroviruses, including the presence of a yet uncharacterized additional open reading frame (ORF3) and the recent evidence for infectivity. It is mobilized with high frequency in the germline of the progeny of females homozygous for the flamenco permissive mutation. W
Role of coreceptors in positive selection and lineage commitment.: EMBO J. 1994 Oct 3;13(19):4482-9. Unique Identifier : AIDSLINE MED/95009949; Chan SH; Waltzinger C; Baron A; Benoist C; Mathis D; Laboratoire de Genetique Moleculaire des Eucaryotes du CNRS,; Unite 184 de Biologie Moleculaire et de Genie Genetique de; l'INSERM, Faculte de Medecine, Strasbourg.; Recent experiments have re-awakened interest in a stochastic/selective model of positive selection of T lymphocytes. A revised version of the model has been proposed whereby commitment of double-positive thymocytes to either the CD4 or CD8 lineage requires two engagements with MHC molecules: the first, initiating the
Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.: EMBO J. 1994 Oct 3;13(19):4504-14. Unique Identifier : AIDSLINE MED/95009951; Kearse KP; Roberts JL; Munitz TI; Wiest DL; Nakayama T; Singer A; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.; The alpha beta T cell antigen receptor (TCR) that is expressed on most T lymphocytes is a multisubunit transmembrane complex composed of at least six different proteins (alpha, beta, gamma, delta, epsilon and zeta) that are assembled in the endoplasmic reticulum (ER) and then transported to the plasma membrane. Expres
DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes.: EMBO J. 1994 Oct 3;13(19):4704-14. Unique Identifier : AIDSLINE MED/95009973; Muller HP; Varmus HE; Department of Microbiology and Immunology, University of; California, San Francisco 94143-0502.; The choice of retroviral integration sites is strongly influenced by chromatin: integration in vitro occurs more efficiently into nucleosomal DNA than into naked DNA, and a characteristic pattern of preferred insertion sites with a 10 bp periodicity is observed at the outer face of the nucleosomal DNA. At least three
Testicular tumor and the acquired immunodeficiency syndrome.: Eur Urol. 1994;26(1):71-6. Unique Identifier : AIDSLINE MED/95010215; Buzelin F; Karam G; Moreau A; Wetzel O; Gaillard F; Department of Pathology, Centre Hospitalier Universitaire,; Nantes, France.; Immunocompromised patients, particularly those suffering from the acquired immunodeficiency syndrome (AIDS), present an increased risk of tumoral pathology. From the observation of a testicular lymphoma associated with Epstein-Barr virus in a HIV + patient, we review 19 cases of testicular tumor in HIV + patients prev
Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice.: Eur J Immunol. 1994 Oct;24(10):2317-22. Unique Identifier : AIDSLINE MED/95010243; Kramer S; Mamalaki C; Horak I; Schimpl A; Kioussis D; Hung T; Institute of Virology and Immunobiology, University of Wurzburg,; Germany.; The requirement for interleukin-2 ( IL-2 ) in repertoire selection and peripheral activation of CD8 T cells was tested in mice rendered IL-2 deficient by gene targeting and expressing a transgenic T cell receptor (TcR) (F5) specific for influenza nucleoprotein (NP) 366-3
The balance between deletion and activation of CD4+8+ thymocytes is controlled by T cell receptor-antigen interactions and is affected by cyclosporin A.: Eur J Immunol. 1994 Oct;24(10):2401-9. Unique Identifier : AIDSLINE MED/95010255; Curnow SJ; Schmitt-Verhulst AM; Centre d'Immunologie, INSERM-CNRS de Marseille-Luminy, Parc; Scientifique de Luminy, France.; The sensitivity of immature thymocytes to antigen-induced deletion has been shown to correlate with their differentiation status. By using an in vitro approach we have investigated whether parameters of antigenic stimulation may also affect the response of thymocytes. Two T cell receptor (TcR)-transgenic (Tg) mouse mo
Induction of tolerance in freshly isolated alloreactive CD4+ T cells by activated T cell stimulators.: Eur J Immunol. 1994 Oct;24(10):2457-61. Unique Identifier : AIDSLINE MED/95010264; Satyaraj E; Rath S; Bal V; National Institute of Immunology, New Delhi, India.; Activated human T cells express major histocompatibility complex class II proteins, and their potential to present antigens to T cell clones has been documented extensively. The effect of such TT presentation on responder T cell clones has been shown to be the induction of tolerance, sometimes accompanied by activatio
Genetic requirements for acceleration of diabetes in non-obese diabetic mice expressing interleukin-2 in islet beta-cells.: Eur J Immunol. 1994 Oct;24(10):2535-41. Unique Identifier : AIDSLINE MED/95010275; Allison J; McClive P; Oxbrow L; Baxter A; Morahan G; Miller JF; Walter and Eliza Hall Institute of Medical Research, PO Royal; Melbourne Hospital, Victoria, Australia.; Diabetes was dramatically accelerated in non-obese diabetic (NOD) transgenic mice that expressed interleukin-2 ( IL-2 ) in their beta cells. A single cross to C57BL/6 completely prevented this effect and a further backcross to the NOD genetic background showed that at le
Municipal drinking water and cryptosporidiosis among persons with AIDS in Los Angeles County.: Epidemiol Infect. 1994 Oct;113(2):313-20. Unique Identifier : AIDSLINE MED/95010375; Sorvillo F; Lieb LE; Nahlen B; Miller J; Mascola L; Ash LR; HIV Epidemiology Program, Los Angeles County Department of Health; Services, CA 90005.; To assess unfiltered drinking water as a source of cryptosporidium infection in patients with the acquired immunodeficiency syndrome (AIDS) the prevalence of cryptosporidiosis among persons with AIDS in Los Angeles County was assessed by water service area. One water distributor, serving approximately 60% of the count
[Efficacy of interventions in drug addiction]: Epidemiol Prev. 1994 Apr;18:94-7. Unique Identifier : AIDSLINE MED/95010450; Davoli M
Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure.: Exp Hematol. 1994 Oct;22(11):1102-10. Unique Identifier : AIDSLINE MED/95010489; Maciejewski JP; Hibbs JR; Anderson S; Katevas P; Young NS; Hematology Branch, National Heart, Lung and Blood Institute,; National Institutes of Health, Bethesda, MD 20892.; Patients with aplastic anemia (AA) respond to immunosuppressive therapy, and several lines of laboratory evidence support a role for cell-mediated immunity in the pathogenesis of marrow failure including expansion of cytotoxic T lymphocytes (CTL) in the blood of AA patients, overexpression of inhibitors such as IFN-ga
Immunological recovery after bone marrow transplantation for severe aplastic anaemia: a Brazilian experience.: Eur J Haematol. 1994 Sep;53(3):150-5. Unique Identifier : AIDSLINE MED/95010588; de Souza MH; Diamond HR; Silva ML; Campos MM; Bouzas LF; Tabak D; Flowers ME; Rumjanek VM; Bone Marrow Unit, Brazilian National Cancer Institute, Rio de; Janeiro.; Twenty-nine patients with severe aplastic anaemia (SAA) were submitted to bone marrow transplantation (BMT) and their immunological recovery analysed. Total lymphocyte counts, estimation of B lymphocytes, T lymphocytes and their subsets, natural-killer (NK) activity were performed. Cells with the CD8+ phenotype and NK
Revisited indications for bone marrow examinations in HIV-infected patients.: Eur J Haematol. 1994 Sep;53(3):168-74. Unique Identifier : AIDSLINE MED/95010591; Ciaudo M; Doco-Lecompte T; Guettier C; d'Agay MF; David F; Rioual N; Buu-Hoi A; Molina JM; Kazatchkine M; Modai J; et al; Laboratory of Haematology, Saint-Louis Hospital, France.; We reviewed the indications for and the results of bone marrow examination (BME) from HIV-infected patients as an attempt to improve its diagnostic yield. One-hundred-and-eight bone marrow specimens from 90 patients during a 3-year period were examined. A cytological, histological and microbiological study was carried
Changes in serum neopterin and serum beta 2-microglobulin in subjects with lung infections.: Eur Respir J. 1994 Jul;7(7):1233-8. Unique Identifier : AIDSLINE MED/95010632; Carstens J; Andersen PL; Dept of Infectious Diseases, Marselisborg Hospital, Aarhus,; Denmark.; Our aim was to investigate whether serum neopterin and beta 2-microglobulin have any value in the distinction between Pneumocystis carinii pneumonia (PCP) and pneumonia due to extracellular bacteria. Also, to study whether neopterin and beta 2-microglobulin would correlate with the clinical course of lung infections i
Magnetic resonance imaging findings in pulmonary Kaposi's sarcoma: a series of 10 cases.: Eur Respir J. 1994 Jul;7(7):1285-9. Unique Identifier : AIDSLINE MED/95010640; Khalil AM; Carette MF; Cadranel JL; Mayaud CM; Akoun GM; Bigot JM; Dept of Radiology, Tenon hospital, Paris, France.; Since chest X-ray and CT scan features of Kaposi s sarcoma (KS) are nonspecific, we wanted to test the hypothesis that the histological components of this tumour and/or the associated haemorrhagic component, may result in a characteristic signal pattern on magnetic resonance imaging (MRI). Thoracic MRI was performed i
Practical considerations in the treatment of the HIV-infected patient.: Dent Clin North Am. 1994 Jul;38(3):403-23. Unique Identifier : AIDSLINE MED/95010956; Barr CE; Albert Einstein College of Medicine, New York, New York.; The HIV-infected patient presents a special challenge to the dentist because of the concerns relative to the diagnosis and management of their oral problems. Concerns about the patient s medical history, medications, and compromising health status, however, make the HIV-positive patient no more special than any other
Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytes.: FASEB J. 1994 Oct;8(13):1055-60. Unique Identifier : AIDSLINE MED/95011142; Loetscher P; Seitz M; Clark-Lewis I; Baggiolini M; Moser B; Theodor-Kocher Institute, University of Bern, Switzerland.; The responses of lymphocytes to six CC chemokines--MCP-1, MCP-2, MCP-3, MIP-1 alpha, MIP-1 beta, and RANTES--were studied using cloned human CD4+ and CD8+ T cells. All CC chemokines tested induced migration of both types of lymphocytes, whereas two CXC chemokines used as controls, IL-8 and IP-10, were inactive. The mo
What kind of food am I?: Gastroenterology. 1994 Oct;107(4):1208-9. Unique Identifier : AIDSLINE MED/95011261; Koretz RL
Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy.: Gastroenterology. 1994 Nov;107(5):1475-80. Unique Identifier : AIDSLINE MED/95011303; Haussinger D; Laubenberger J; vom Dahl S; Ernst T; Bayer S; Langer M; Gerok W; Hennig J; Medizinische und Radiologische Universitatsklinik Freiburg,; Germany.; BACKGROUND/AIMS: Recent in vivo studies using proton magnetic resonance (1H-MR) spectroscopy showed low levels of myo-inositol in the brain in hepatic encephalopathy; the pathogenetic relevance of this observation is unclear. METHODS: Myo-inositol and glutamine levels in the brain were studied in vivo by 1H-MR spectro
Endoscopy in the age of HIV: a study of current practices and attitudes.: Gastrointest Endosc. 1994 Jul-Aug;40(4):477-80. Unique Identifier : AIDSLINE MED/95011340; Shapiro M; Brandt LJ; Department of Medicine, Montefiore Medical Center, Bronx, New; York 10467.; Gastroenterologists are frequently asked to perform a variety of endoscopic procedures in patients with AIDS. A study published 6 years ago concluded that costly and inefficient practices resulted from anxiety about transmitting human immunodeficiency virus (HIV) to endoscopic personnel. We re-examined, by means of a
Prospective endoscopic characterization of cytomegalovirus esophagitis in AIDS.: Gastrointest Endosc. 1994 Jul-Aug;40(4):481-4. Unique Identifier : AIDSLINE MED/95011341; Wilcox CM; Straub RF; Schwartz DA; Department of Medicine, Emory University School of Medicine,; Atlanta, Georgia 30303.; Cytomegalovirus ( CMV ) esophagitis is an important cause of esophageal ulceration in patients with the acquired immunodeficiency syndrome. However, the endoscopic appearance of these lesions has not been well characterized. During a 3-year period, we identified 1
Tic disorder associated with encephalopathy in advanced HIV disease [letter]: Gen Hosp Psychiatry. 1994 Jul;16(4):298-300. Unique Identifier : AIDSLINE MED/95011516; McDaniel JS; Summerville MB
HIV-related thrombotic thrombocytopenic purpura (TTP) as first clinical manifestation of infection.: Haematologica. 1994 May-Jun;79(3):277-9. Unique Identifier : AIDSLINE MED/95011810; Cruccu V; Parisio E; Pedretti D; Villa A; Confalonieri F; III Medical Department, Fatebenefratelli-Oftalmico Hospital,; Milan, Italy.; A case of thrombotic thrombocytopenic purpura (TTP) in a 40-year-old bisexual man unaware of being HIV positive is reported. The hematologic syndrome represented the first clinical manifestation of this viral infection. The clinical picture, characterized by severe hemolytic microangiopathic anemia, thrombocytopenia,
Thrombotic thrombocytopenic purpura associated with HIV infection: report of two cases.: Haematologica. 1994 May-Jun;79(3):280-2. Unique Identifier : AIDSLINE MED/95011811; Nosari AM; Landonio G; Caggese L; Cattaneo D; Muti G; Volonterio A; Division of Hematology, Niguarda Ca Granda Hospital, Milan,; Italy.; We report two cases of thrombotic thrombocytopenic purpura (TTP) in advanced stage HIV-positive patients (CD4+
[Superantigens in human disease]: Harefuah. 1994 Jun 15;126(12):719-23. Unique Identifier : AIDSLINE MED/95011847; Toeg A; Harach G; Schaffer-Arlozorov R; Zahavi J
[Nutrition and HIV infection]: Harefuah. 1994 Aug;127(3-4):133-7. Unique Identifier : AIDSLINE MED/95011866; Lasry Y; Berner Y; Bentwich Z
Microsporidiosis in HIV positive patients: current methods for diagnosis using biopsy, cytologic, ultrastructural, immunological, and tissue culture techniques.: Folia Parasitol (Praha). 1994;41(2):101-9. Unique Identifier : AIDSLINE MED/95011889; Schwartz DA; Bryan RT; Weber R; Visvesvara GS; Department of Pathology, Emory University School of Medicine,; Atlanta, GA.; Microsporidiosis is an increasingly important opportunistic infection in HIV-positive patients. Five species of microsporidia (Enterocytozoon bieneusi, Encephalitozoon hellem and E. cuniculi, Septata intestinalis, and Pleistophora sp.) have been reported to occur in AIDS, with each agent producing a different clinicop
Federal funding for health services research on AIDS, 1986-1991.: Health Aff (Millwood). 1994 Summer;13(3):261-6. Unique Identifier : AIDSLINE MED/95012004; Rudzinski KA; Marconi KM; McKinney MM
[The effect of CD8+ cells on isolation and replication of HIV-1]: Hokkaido Igaku Zasshi. 1994 May;69(3):411-22. Unique Identifier : AIDSLINE MED/95012026; Tateno Y; Department of Pediatrics, Hokkaido University School of Medicine,; Sapporo, Japan.; Human immunodeficiency virus type 1 (HIV-1) seropositive individuals are known to have a population of CD8+T lymphocytes which can suppress the replication of the virus. Two hundred and twelve peripheral blood mononuclear cells (PBMC) samples obtained from 42 seropositive individuals were examined for HIV-1 isolation.
[The influence of subclinical level of graft versus host reaction on reconstitution of host lymphoid tissues]: Hokkaido Igaku Zasshi. 1994 May;69(3):453-65. Unique Identifier : AIDSLINE MED/95012030; Hirano M; Third Department of Internal Medicine, Hokkaido University School; of Medicine, Sapporo, Japan.; In this study reconstitution of lymphoid tissues under the influence of subclinical graft versus host reaction (GVHR) was investigated. Lethally irradiated recipient mice (AKR: H-2k, Mls-1a) were reconstituted with donor (B10: H-2b, Mls-1b) bone marrow (BM) cells treated with anti-Thy 1 antibody alone without compleme
[Pathological and molecular analyses of mammary tumors induced in HTLV-I pX transgenic rats]: Hokkaido Igaku Zasshi. 1994 May;69(3):479-91, 493, 495-7. Unique Identifier : AIDSLINE MED/95012032; Yamada S; Department of Pediatrics, Hokkaido University School of Medicine,; Sapporo, Japan.; The pX gene of human T-cell leukemia virus type I (HTLV-I) is known to be a potent transactivator of the viral gene and the host genes which are important for cell proliferation in vitro. It has been reported that various diseases occur in transgenic mice harboring either tax, pX, or env-pX gene, such as mesenchymal t
Hepatitis C in HIV-infected patients with and without AIDS: prevalence and relationship to patient survival.: Hepatology. 1994 Nov;20(5):1152-5. Unique Identifier : AIDSLINE MED/95012127; Wright TL; Hollander H; Pu X; Held MJ; Lipson P; Quan S; Polito A; Thaler MM; Bacchetti P; Scharschmidt BF; Department of Medicine, University of California, San Francisco; 94121.; BACKGROUND: Limited information is available about the prevalence of hepatitis C virus in patients with human immunodeficiency virus in relation to specific risk factors or about the influence of hepatitis C virus coinfection on survival. This retrospective study addressed these questions. METHODS: The study populatio
Histopathology of cerebral toxoplasmosis in human immunodeficiency virus infection: a comparison between patients with early-onset and late-onset acquired immunodeficiency syndrome.: Hum Pathol. 1994 Oct;25(10):1091-7. Unique Identifier : AIDSLINE MED/95012208; Falangola MF; Reichler BS; Petito CK; Department of Pathology, University of Miami School of Medicine,; FL 33136.; We reviewed the histological features of untreated toxoplasmosis in 18 cases with the acquired immunodeficiency syndrome (AIDS), eight of which were surgical biopsies and 10 of which were autopsy specimens. The results were compared according to the clinical status of the patient at the time the diagnosis of toxoplasm
Human T-lymphotropic virus type I DNA in spinal cord of tropical spastic paraparesis with concomitant human T-lymphotropic virus type I-negative Hodgkin's disease.: Hum Pathol. 1994 Oct;25(10):1101-6. Unique Identifier : AIDSLINE MED/95012210; Navarro-Roman L; Corbin DO; Katz D; Callender DP; Prussia PR; Garriques S; Fraser HS; Jaffe ES; Roman GC; Department of Pathology, School of Medicine, UT Health Science; Center, San Antonio, 78284-7750.; We studied a 58-year-old black woman from Barbados who simultaneously developed myelopathy and lymphoma with human T-lymphotropic virus type I (HTLV-I) antibodies in serum and cerebrospinal fluid and died 3 years after onset. Neuropathological examination showed typical tropical
TRendys in biochemistry.: Indian J Biochem Biophys. 1994 Apr;31(2):88-90. Unique Identifier : AIDSLINE MED/95012347; Gupta RK
[Immunohistochemical characterization of the intestinal immune system of patients with AIDS]: Immun Infekt. 1994 Feb;22(1):26-7. Unique Identifier : AIDSLINE MED/95012371; Lennartz EG; Herbst EW; Peter HH; Pathologisches Institut, Abteilung Rheumatologie, Universitat; Freiburg.; Lamina propria mononuclear cells in duodenal and colonic biopsies of AIDS patients and controls were immunohistologically studied for T-cells (CD3), IgA1+, IgA2+, IgM+, IgG2+, IgG4+ and J-chain-positive cells. In AIDS patients, there was a decrease of IgA1+ (p = 0.0009), IgA2+ (p = 0.011), IgM+ (p = 0.018), IgG4+ (p =
[Roche begins phase III study with a new AIDS medication]: Immun Infekt. 1994 Jun;22(3):VI. Unique Identifier : AIDSLINE MED/95012376
[The Th1/Th2 concept--its importance for regulation of IgE]: Immun Infekt. 1994 Jun;22(3):88-93. Unique Identifier : AIDSLINE MED/95012384; Haas H; Schlaak M; Medizinische Klinik, Forschungsinstitut Borstel.; T helper type 2 (TH2) cells are a major source of interleukin- (IL-)4 which plays a critical role in the induction of the IgE synthesis. Their counterplayers, the T helper type 1 (TH1) cells produce interferon- (IFN-)gamma which inhibits the IL-4-induced IgE synthesis. Thus, the TH2/TH1 ratio plays an important role i
[Important study demonstrates anew the utility of early AZT therapy]: Immun Infekt. 1994 Aug;22(4):III. Unique Identifier : AIDSLINE MED/95012386
[Avian mycobacteria]: Immun Infekt. 1994 Aug;22(4):131-6. Unique Identifier : AIDSLINE MED/95012387; Schroder KH; Naumann L; Forschungsinstitut Borstel.; The avian mycobacteria have been identified first in relation to their virulence for hens. But this property was not definitely to correlate with serovars. Furthermore, this heterogenicity was to confirm on molecular level. Therefore it was necessary to introduce a M.avium complex beside true M.avium. M.avium has spec
Chlamydia trachomatis and HIV infection.: Immunol Lett. 1994 Apr;40(1):27-30. Unique Identifier : AIDSLINE MED/95012425; Schattner A; Hanuka N; Sarov B; Bentwich Z; Division of Medicine, Kaplan Hospital, Rehovot, Israel.; To study the interactions between Chlamydia trachomatis (CT) and human immunodeficiency virus (HIV) infections, we examined CT serologies in sequential serum samples of male homosexuals (MHS), followed over a mean period of 4 years. Of the MHS studied, 77 were HIV(-), 18 were HIV(+) and 10 patients seroconverted durin
Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene [published erratum appears in Immunogenetics 1995;42(1):76]: Immunogenetics. 1994;40(5):331-8. Unique Identifier : AIDSLINE GENBANK/U13735; Abbott CA; Baker E; Sutherland GR; McCaughan GW; A. W. Morrow Gastroenterology and Liver Centre, Royal Prince; Alfred Hospital, Sydney, Australia.; CD26 is a lymphocyte cell surface antigen which is increased during T-cell activation and is also expressed in other tissues. It is an atypical serine protease belonging to the prolyl oligopeptidase family. CD26 has been implicated in a variety of biological functions including T-cell activation, cell-to-cell adhesion
Comparison of the indirect immunofluorescence assay with western blot for the detection of HIV antibody.: Indian J Med Res. 1994 Apr;99:143-8. Unique Identifier : AIDSLINE MED/95012481; Abraham P; Babu PG; John TJ; Department of Microbiology, Christian Medical College Hospital,; Vellore.; With the increase in the prevalence of human immunodeficiency virus (HIV) infection in India , there is an urgent need to explore cost-containing methods of HIV antibody detection. We compared the indirect immunofluorescence assay (IFA) with the widely used but expensive confirmatory
Rising trend in the prevalence of HIV infection among blood donors.: Indian J Med Res. 1994 May;99:195-7. Unique Identifier : AIDSLINE MED/95012491; Bhushan N; Pulimood BR; Babu PG; John TJ; Department of Microbiology, Christian Medical College & Hospital,; Vellore.; The prevalence of HIV infection among blood donors was analysed, for the five year period from April 1988 to March 1993. All donors were patients relatives or volunteers; no paid/commercial donors were accepted. Each year between 14,084 and 15,544 donor blood samples were screened by ELISA and those found reactive we
Acquired immunodeficiency syndrome and its ocular complications.: Indian J Ophthalmol. 1994 Jun;42(2):51-63. Unique Identifier : AIDSLINE MED/95012549; Rao NA; Doheny Eye Institute, Los Angeles, California 90033.; Human immunodeficiency virus infection is the first major pandemic of the 20th century. At present, almost 10 million people are known to be infected with this virus, and it is estimated that by the year 2000, approximately 40 million people will be infected. Transmission of this deadly infection is predominantly by s
Mycobacterium bovis BCG priming induces a strong potentiation of the antibody response induced by recombinant BCG expressing a foreign antigen.: Infect Immun. 1994 Oct;62(10):4287-95. Unique Identifier : AIDSLINE MED/95012613; Gheorghiu M; Lagranderie MR; Gicquel BM; Leclerc CD; Laboratoire du BCG, Institut Pasteur, Paris, France.; Several recent studies have demonstrated that strong cellular or humoral immune responses can be induced against foreign antigens expressed by recombinant Mycobacterium bovis BCG. It has therefore been suggested that BCG could represent one of the best candidate vectors for live recombinant vaccines. However, a large
Interleukin-10 is expressed by bovine type 1 helper, type 2 helper, and unrestricted parasite-specific T-cell clones and inhibits proliferation of all three subsets in an accessory-cell-dependent manner.: Infect Immun. 1994 Nov;62(11):4697-708. Unique Identifier : AIDSLINE MED/95012676; Brown WC; Woods VM; Chitko-McKown CG; Hash SM; Rice-Ficht AC; Department of Veterinary Pathobiology, Texas A&M University,; College Station 77843.; Murine interleukin-10 (IL-10) is produced by type 2 helper (Th2) cells and selectively inhibits cytokine synthesis by type 1 helper (Th1) cells, whereas human IL-10 is produced by and inhibits proliferation and cytokine synthesis by both Th1 and Th2 subsets. This study reports that bovine IL-10 mRNA is expressed by Th
Use of anti-CD4+ hybridoma cells to induce Pneumocystis carinii in mice.: Infect Immun. 1994 Nov;62(11):4887-92. Unique Identifier : AIDSLINE MED/95012703; McFadden DC; Powles MA; Smith JG; Flattery AM; Bartizal K; Schmatz DM; Merck Research Laboratories, Rahway, New Jersey 07065-0900.; A reduction of peripheral CD4+ cell levels has been correlated with the onset of Pneumocystis carinii pneumonia in AIDS patients. Most in vivo drug discovery and development for P. carinii have been conducted in corticosteroid-treated rats. There is need for the development of new small animal models with more selecti
Role for CD8+ T cells in antichlamydial immunity defined by Chlamydia-specific T-lymphocyte clones.: Infect Immun. 1994 Nov;62(11):5195-7. Unique Identifier : AIDSLINE MED/95012748; Igietseme JU; Magee DM; Williams DM; Rank RG; Department of Microbiology and Immunology, University of Arkansas; for Medical Sciences, Little Rock 72205.; The role of CD8+ T cells in antichlamydial immunity was investigated in a murine model of chlamydial genital infection by using T-cell clones generated against the Chlamydia trachomatis agent of mouse pneumonitis (MoPn). Two CD8+ T-cell clones tested (2.1F and 2.14-9) were chlamydia antigen specific and MHC restricted
A seroepidemiological study of human immunodeficiency virus infection in northeast Zaire.: Infection. 1994 May-Jun;22(3):174-7. Unique Identifier : AIDSLINE MED/95012754; Bernal MC; Galan MI; Ocete MD; Leyva A; Garcia F; Garcia-Valdecasas J; Maroto MC; Piedrola G; Dept. of Microbiology, Faculty of Medicine, Granada, Spain.; To evaluate the incidence of human immunodeficiency virus type 2 infections in an endemic African area, we have studied 134 patients from Northeast Zaire . Sera were tested for HIV-1 and HIV-2 antibodies to asses cross-reactivity or a possible double infection. Sixty five (48.5%) s
Foscarnet and ganciclovir combination therapy for CMV disease in HIV-infected patients.: Infection. 1994 May-Jun;22(3):197-200. Unique Identifier : AIDSLINE MED/95012759; Salzberger B; Stoehr A; Heise W; Fatkenheuer G; Schwenk A; Franzen C; Cornely O; Schrappe M; Medizinische Klinik I, Universitatsklinik Koln, Germany.; An open prospective trial of combined ganciclovir and foscarnet therapy for 3 weeks was initiated in 14 episodes of severe CMV-disease in 13 HIV-infected patients (all CDC class IV, age 30-42, median 34 years, CD4+ cell count 0-80, median 10/microliters). In seven episodes of gastrointestinal disease (five colitis, tw
Role of autoimmunity in protein S deficiency during HIV-1 infection.: Infection. 1994 May-Jun;22(3):201-3. Unique Identifier : AIDSLINE MED/95012760; Lafeuillade A; Sorice M; Griggi T; Pellegrino P; Geoffroy M; Profizi N; Dept. of Infectious Diseases, Chalucet Hospital, Toulon, France.; The objective of the study was to evaluate the role of autoimmune mechanisms in the pathophysiology of protein S deficiency during HIV-1 infection. In a prospective study the correlation between protein S activity and the presence of anti-protein S autoantibodies or anti-cardiolipin antibodies in HIV-1-positive patien
No evidence of mycoplasmas in peripheral blood mononuclear cell fraction of HIV-infected patients.: Infection. 1994 May-Jun;22(3):204-6. Unique Identifier : AIDSLINE MED/95012761; van Kuppeveld F; Melchers W; Kissing J; van der Logt J; Galama J; Dept. of Microbiology, University of Nijmegen, The Netherlands.; In this study, the prevalence of mycoplasmas in peripheral blood mononuclear cells (PBMC) from HIV-infected individuals was investigated using a mycoplasma genus-specific PCR assay. No mycoplasmas were detected in the PBMC samples from any of the 25 HIV-infected individuals (CDC 2, n = 8; CDC 3, n = 2; CDC 4, n = 15)
Plasma fibronectin levels in patients with HIV-1 infection (Infection 22 [1994] 116) [letter; comment]: Infection. 1994 May-Jun;22(3):219. Unique Identifier : AIDSLINE MED/95012766; Rodriguez-Cuartero A; Nunez-Carril J
Simultaneous occurrence of visceral leishmaniasis and disseminated histoplasmosis in an Italian patient with HIV infection [letter]: Infection. 1994 May-Jun;22(3):224-5. Unique Identifier : AIDSLINE MED/95012769; Manfredi R; Mazzoni A; Pileri S; Marinacci G; Nanetti A; Poggi S; Chiodo F
Optimal adaptive control of pharmacodynamic effects with aminoglycoside antibiotics: a required approach for the future.: Int J Biomed Comput. 1994 Jun;36(1-2):43-57. Unique Identifier : AIDSLINE MED/95012803; Garraffo R; Department of Pharmacology, Hospital Pasteur, Nice, France.; Many factors are considered in designing optimal drug regimens, including dose, route of administration, and the frequency and rate of administration. It is evident that the first parameter to be considered in dosage regimen determinations is the pharmacokinetics of the drug in the treated patient, or more extensively
Expression of an endogenous retroviral gene product in human placenta.: Int J Cancer. 1994 Sep 15;58(6):836-40. Unique Identifier : AIDSLINE MED/95012822; Kitamura M; Maruyama N; Shirasawa T; Nagasawa R; Watanabe K; Tateno M; Yoshiki T; Department of Molecular Pathology, Tokyo Metropolitan Institute; of Gerontology, Japan.; To investigate the presence and potential pathophysiological role of endogenous retroviruses in humans, we prepared a recombinant protein using clone 4-I, a proviral sequence. DNA fragments containing the env region of clone 4-I were subcloned into a prokaryotic expression vector (pET3), and 2 fusion proteins, SU413 a
HIV-associated lymphoma in Africa: an autopsy study in Cote d'Ivoire.: Int J Cancer. 1994 Oct 1;59(1):20-4. Unique Identifier : AIDSLINE MED/95012846; Lucas SB; Diomande M; Hounnou A; Beaumel A; Giordano C; Kadio A; Peacock CS; Honde M; De Cock KM; Projet RETRO-CI, Abidjan, Cote d'Ivoire.; HIV infection predisposes to the development of non-Hodgkin lymphoma (NHL). The frequency of NHL among HIV-positive adults and children in sub-Saharan Africa is not known. In 1991-1992, a representative autopsy study of HIV infection was performed in Abidjan, Cote d Ivoire . Of
DNA of lymphoma-associated herpesvirus (HVMF1) in SIV-infected monkeys (Macaca fascicularis) shows homologies to EBNA-1, -2 and 5 genes.: Int J Cancer. 1994 Oct 15;59(2):287-95. Unique Identifier : AIDSLINE GENBANK/X77781; Li SL; Biberfeld P; Ernberg I; Immunopathology Laboratory, Karolinska Institute, Stockholm,; Sweden.; We have characterized a new Epstein-Barr-virus(EBV)-like herpesvirus associated with lymphomas of SIV-infected cynomolgus (Macaca fascicularis) monkeys and propose that this virus is designated herpesvirus macaca fascicularis I (HVMFI). Genomic regions in HVMF1 of potential significance for tumor pathogenesis were ana
Detection of neutralizing antibodies against human T-cell leukemia virus type 1 using a cell-free infection system and polymerase chain reaction.: Int J Cancer. 1994 Nov 1;59(3):416-21. Unique Identifier : AIDSLINE MED/95012902; Haraguchi Y; Yang DW; Handa A; Shimizu N; Tanaka Y; Hoshino H; Department of Hygiene and Virology, Gunma University School of; Medicine, Japan.; We have developed a cell-free infection system to titrate neutralizing antibodies against human T-cell leukemia virus type 1 (HTLV-1) using the polymerase chain reaction (PCR). S+L-CCC (8C) feline kidney or U-251 MG human glioma cells were infected with a cell-free culture supernatant derived from HTLV-1-infected c77
Sterilization of HIV by gamma irradiation. A bone allograft model.: Int Orthop. 1994 Jun;18(3):172-6. Unique Identifier : AIDSLINE MED/95012918; Campbell DG; Li P; Stephenson AJ; Oakeshott RD; Orthopaedic Surgery Unit, Royal Adelaide Hospital North Terrace,; Australia.; A human immuno-deficiency virus (HIV) infected bone allograft model has been created using HTLV-IIIB virus in a concentration simulating a massively HIV infected bone allograft donor [HTLV-III is the denomination initially given to the human immuno-deficiency by the american team of Prof. Gallo. It represent the virus
AIDS vaccines and adjuvant formulations.: Int J Immunopharmacol. 1994 May-Jun;16(5-6):369-79. Unique Identifier : AIDSLINE MED/95012932; Cernescu CE; St. Nicolau Institute of Virology, Bucharest, Romania.; The AIDS epidemic is too large to continue ignoring prevention programs that appear to work. In this review the promising experimental immunogens and how close they are to the optimal requirements for a preventive vaccine are presented. Adjuvants and adjuvant formulations (mainly mixtures of adjuvants with suitable ve
Cytokines in HIV infection.: Int J Immunopharmacol. 1994 May-Jun;16(5-6):391-6. Unique Identifier : AIDSLINE MED/95012935; Emilie D; Fior R; Jarrousse B; Marfaing-Koka A; Merrien D; Devergne O; Crevon MC; Maillot MC; Galanaud P; INSERM U131, Clamart, France.; Human immunodeficiency virus infection leads to a deregulated production of a number of cytokines. Some of them (IL-1, IL-6, TNF-alpha, interferon-gamma) are produced in increased amounts in vivo, whereas the production of IL-2 is decreased. This latter abnormality pla
The evolution of a public health policy: health care providers and the transmission of HIV.: Int J Health Serv. 1994;24(3):535-48. Unique Identifier : AIDSLINE MED/95012971; Guttmacher S; Department of Health Studies New York University, NY 10012.; The single known instance of transmission of HIV from a health care provider to a patient raised issues concerning the responsibility of clinicians to their patients, and sparked debate over policies to prevent the spread of HIV in health care facilities. The intensity and politicization of the debate were reflected i
Molluscum contagiosum.: Int J Dermatol. 1994 Jul;33(7):453-61. Unique Identifier : AIDSLINE MED/95012979; Gottlieb SL; Myskowski PL; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, New York 10021.
Photodermatosis in association with the acquired immune deficiency syndrome [letter; comment]: Int J Dermatol. 1994 Jul;33(7):523-4. Unique Identifier : AIDSLINE MED/95013003; Colebunders R; Fleerackers Y; Stevens A; Van Damme P
Molecular structures of CPF-dipeptides, inhibitors for the binding of CD4 with gp120.: Int J Pept Protein Res. 1994 Jun;43(6):520-8. Unique Identifier : AIDSLINE MED/95013040; Venkatramani L; Hossain MB; Van der Helm D; Department of Chemistry & Biochemistry, University of Oklahoma,; Norman.; The dipeptides N-carbomethoxycarbonyl-prolyl-phenylalanyl-benzyl esters (CPFs) play a significant role in the prevention of HIV-1 virus infection by interacting with the glycoprotein gp120, one of the envelope proteins of the HIV-1 virus. Of the four possible isomers of CPF, (L-pro-L-phe), (L-pro-D-phe), (D-pro-L-phe)
[The principal causes of mortality in young people in the Autonomous Community of Madrid: 1990-1991]: Gac Sanit. 1994 May-Jun;8(42):117-21. Unique Identifier : AIDSLINE MED/95013052; Sarasqueta Eizaguirre C; Zunzunegui Pastor MV; Area de Epidemiologia, Centro Universitario de Salud Publica,; Madrid.; Our objective is to quantify the mortality from AIDS, narcotic related deaths, and traffic accidents among those between 15 and 39 years of age, in the Community of Madrid, 1990-1991. Data provided by the Regional Register of AIDS, Forensic Institute of Madrid, local police teams and the Traffic Directorate General ha
[An improvement in the AIDS mortality statistics in Catalonia]: Gac Sanit. 1994 May-Jun;8(42):122-7. Unique Identifier : AIDSLINE MED/95013053; Mingot M; Salas T; Segura A; Casabona J; Unitat de Qualitat Assistencial, Institut Catala de la Salut,; Lleida.; Differences between the number of AIDS death reported to the mortality register and to the AIDS register in Catalonia, Spain are relatively small, due to bot registers cooperation. Official mortality statistics are able to identify 78% of AIDS deaths. This proportion can be increase
Patterns of ambulatory care for AIDS patients, and association with emergency room use.: Health Serv Res. 1994 Oct;29(4):489-510. Unique Identifier : AIDSLINE MED/95013356; Mauskopf J; Turner BJ; Markson LE; Houchens RL; Fanning TR; McKee L; Division of International Surveillance, Epidemiology, and; Economic Research, Burroughs Wellcome Co., Research Triangle; Park, NC.; OBJECTIVE. We examined the association of patterns of ambulatory care for AIDS patients with any use of the emergency room (ER) and the monthly rate of ER visits in the six months after AIDS diagnosis. DATA SOURCES/STUDY SETTING. The study population was obtained from the New York State Medicaid HIV/AIDS Research Data
[AIDS]: HNO. 1994 Jul;42(7):447-59. Unique Identifier : AIDSLINE MED/95013435; L'age M; L'age-Stehr J; II. Innere Abteilung des Auguste-Viktoria-Krankenhauses Berlin.
Influence of HLA class I and class II antigens on the peripheral T-cell receptor repertoire.: Hum Immunol. 1994 Jun;40(2):111-22. Unique Identifier : AIDSLINE MED/95013446; Reed EF; Tugulea SL; Suciu-Foca N; Department of Pathology, College of Physicians and Surgeons of; Columbia University, New York City, New York.; Using TCR-specific mAbs, we analyzed the TCR distribution in the CD4 and CD8 compartments of peripheral blood T cells from members of six families, including two which were informative for an HLA-B/DR crossover. TCR distribution in the CD4 compartment is influenced by MHC class II antigens as it was similar in the chi
Nonrandom T-cell receptor J beta usage pattern in human CD4+ and CD8+ peripheral T cells.: Hum Immunol. 1994 Jun;40(2):93-100. Unique Identifier : AIDSLINE MED/95013454; Jeddi-Tehrani M; Grunewald J; Hodara V; Andersson R; Wigzell H; Department of Immunology, Karolinska Institute, Stockholm,; Sweden.; Association frequencies of TCR J beta gene segments with six V beta families (V beta 3, 6.1-3, 8, 9, 12, and 18) were analyzed in T-cell populations obtained from healthy blood donors. The six selected V beta families are located at various chromosomal positions relative to other recombinatorial elements (D beta, J be
[AIDS Project--Adam and Eve Cohabitation Consultation]: Jordemodern. 1994 Mar;107(3):75-6. Unique Identifier : AIDSLINE MED/95013547; Isaksson I
Subtype analysis of HTLV-1 in patients with HTLV-1 uveitis.: Jpn J Cancer Res. 1994 Aug;85(8):767-70. Unique Identifier : AIDSLINE MED/95013646; Ono A; Miura T; Araki S; Yamaguchi K; Takatsuki K; Mori S; Hayami M; Mochizuki M; Watanabe T; Department of Pathology, University of Tokyo.; The hypothesis that HTLV-1 uveitis, a recently identified disease entity associated with human T-cell leukemia virus type I (HTLV-1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTLV-1 from five patients with HTLV-1 uveitis (HU) and four with adult T
HTLV-II non-integrated malignant lymphoma induction in Japanese white rabbits following intravenous inoculation of HTLV-II-infected simian leukocyte cell line (Si-IIA).: Jpn J Cancer Res. 1994 Aug;85(8):808-18. Unique Identifier : AIDSLINE MED/95013653; Hayashi K; Ohara N; Koirala TR; Ino H; Chen HL; Teramoto N; Kondo E; Yoshino T; Takahashi K; Yamada M; et al; Second Department of Pathology, Okayama University Medical; School.; Lymphoma induction in rabbits by an unknown factor derived from an HTLV-II-producing simian (Cynomolgus) leukocyte cell line (Si-IIA) is reported. Thirteen of 17 male Japanese white rabbits (76%) inoculated intravenously with Si-IIA cells developed malignant lymphoma including Hodgkin-like lymphoma between 62 and 167
Induction mechanism of human blood CD8+ T cell proliferation and cytotoxicity by natural killer cell stimulatory factor (interleukin-12).: Jpn J Cancer Res. 1994 Aug;85(8):853-61. Unique Identifier : AIDSLINE MED/95013659; Nabioullin R; Sone S; Nii A; Haku T; Ogura T; Third Department of Internal Medicine, University of Tokushima; School of Medicine.; Natural killer cell stimulatory factor (NKSF/IL-12) has been found to induce cytotoxic activity of human blood T cells. In the present study, the effect of NKSF on induction of cytotoxic CD8+ T cells in the presence or absence of monocytes was examined. Highly purified lymphocytes (> 99%) and monocytes (> 90%) were is
Toxoplasmosis and human immunodeficiency virus (HIV) disease.: J Antimicrob Chemother. 1994 Jun;33(6):1079-82. Unique Identifier : AIDSLINE MED/95013835; New LC; Holliman RE; PHLS Toxoplasma Reference Unit, St George's Hospital, London, UK.
Effect of pentamidine on the growth of Cryptococcus neoformans.: J Antimicrob Chemother. 1994 Jun;33(6):1229-32. Unique Identifier : AIDSLINE MED/95013850; Barchiesi F; Del Poeta M; Morbiducci V; Ancarani F; Scalise G; Institute of Infectious Diseases and Public Health, University of; Ancona, Italy.
1993: the year in perspective.: J Ark Med Soc. 1994 Jul;91(2):88-90. Unique Identifier : AIDSLINE MED/95013985; Bunch J; Thomasson B
Suramin inhibits binding of the V3 region of HIV-1 envelope glycoprotein gp120 to galactosylceramide, the receptor for HIV-1 gp120 on human colon epithelial cells.: J Biol Chem. 1994 Sep 30;269(39):24349-53. Unique Identifier : AIDSLINE MED/95014178; Yahi N; Sabatier JM; Nickel P; Mabrouk K; Gonzalez-Scarano F; Fantini J; CNRS URA 1455, Faculte de Medecine Nord, Marseille, France.; The infection of human colonic epithelial cells HT-29 by human immunodeficiency virus type 1 (HIV-1) occurs independently of CD4, the main HIV-1 receptor expressed on lymphocytes and macrophages. Recent studies from our group have shown that HT-29 cells express the glycosphingolipid galactosylceramide (GalCer), a pote
Potential of azidothymidine to activate the HIV-1 promoter.: J Biol Chem. 1994 Oct 7;269(40):24553-6. Unique Identifier : AIDSLINE MED/95014212; Kurata S; Department of Biochemical Genetics, Tokyo Medical and Dental; University, Japan.; Azidothymidine ( AZT ) has been used for treatment of acquired immunodeficiency syndrome (AIDS), but a recent concord trial showed that it is ineffective for suppressing the development of AIDS. In this study, the effects of AZT on three cell lines tran
The influence of DNA and nucleosome structure on integration events directed by HIV integrase.: J Biol Chem. 1994 Oct 7;269(40):25031-41. Unique Identifier : AIDSLINE MED/95014279; Pruss D; Reeves R; Bushman FD; Wolffe AP; Laboratory of Molecular Embryology, NICHHD, National Institutes; of Health, Bethesda, Maryland 20892.; DNA copies of the human immunodeficiency virus (HIV) genome integrate nonrandomly into the chromosomal DNA of the host cell. In this report, we investigate the molecular basis of this selectivity using the virus-encoded HIV integrase to direct integration of a synthetic HIV long terminal repeat substrate into either D
The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.: J Biol Chem. 1994 Oct 14;269(41):25426-31. Unique Identifier : AIDSLINE MED/95014339; Olah Z; Lehel C; Anderson WB; Eiden MV; Wilson CA; Laboratory of Cellular Oncology, NCI, National Institutes of; Health, Bethesda, Maryland 20892.; The primate type C retrovirus gibbon ape leukemia virus (GaLV) has been shown to use a widely expressed, multiple membrane-spanning protein of unknown function as its cell surface receptor on human cells (GLVR1) (Johann, S. V., Gibbons, J. J., and O Hara, B. (1992) J. Virol. 66, 1635-1640; O Hara, B., Johann, S. V., K
Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases.: J Biol Chem. 1994 Oct 21;269(42):26344-8. Unique Identifier : AIDSLINE MED/95014470; Chen Z; Li Y; Chen E; Hall DL; Darke PL; Culberson C; Shafer JA; Kuo LC; Department of Biological Chemistry, Merck Research Laboratories,; West Point, Pennsylvania 19486.; L-735,524 is a potent, orally bioavailable inhibitor of human immunodeficiency virus (HIV) protease currently in a Phase II clinical trial. We report here the three-dimensional structure of L-735,524 complexed to HIV-2 protease at 1.9-A resolution, as well as the structure of the native HIV-2 protease at 2.5-A resolut
Mutually exclusive binding of peptide and invariant chain to major histocompatibility complex class II antigens.: J Biol Chem. 1994 Oct 21;269(42):26531-8. Unique Identifier : AIDSLINE MED/95014498; Ericson ML; Sundstrom M; Sansom DM; Charron DJ; Laboratoire d'Immunogenetique Humaine, INSERM U.396, Institut; des Cordeliers, Paris, France.; The invariant chain is a membrane protein associated with the major histocompatibility complex class II antigens both intra- and extracellularly. The extracellular portion of the human invariant chain (Ii) was expressed in Escherichia coli as a fusion protein with a polyhistidine tail and purified by metal affinity ch
The reproductive careers of a cohort of men and women following an HIV-positive diagnosis.: J Biosoc Sci. 1994 Jul;26(3):409-15. Unique Identifier : AIDSLINE MED/95014618; Green G; MRC Medical Sociology Unit, Glasgow.; This report examines the consequences of a positive HIV diagnosis upon the reproductive decision-making of 39 men and women in Scotland. Whilst the majority initially decide never to have any (more) children this sometimes changes as other factors gain ascendancy, such as a partner wanting their child and about one-
Abscesses secondary to parenteral abuse of drugs. A study of demographic and bacteriological characteristics.: J Bone Joint Surg Am. 1994 Oct;76(10):1526-30. Unique Identifier : AIDSLINE MED/95014630; Schnall SB; Holtom PD; Lilley JC; Department of Orthopaedics, University of Southern California; Medical Center, Los Angeles.; Seventy-seven patients (eighty-six lesions) who had been seen over a fifteen-month period because of an abscess at the site of injection due to parenteral abuse of drugs were identified in a retrospective review. Forty-one patients (forty-five abscesses) had had cultures before antibiotic therapy. Thirty (73 per cent)
Long-term survivors of HIV infection.: Hosp Pract (Off Ed). 1994 Oct 15;29(10):41-4, 47, 51-2. Unique Identifier : AIDSLINE MED/95014838; Levy JA; Department of Medicine, University of California, San Francisco,; School of Medicine.; The persistent immune competence seen in a small percentage of HIV-infected individuals reflects the heterogeneity of both the virus and the host. Some HIV strains, for example, are more cytopathic than others. Host factors that promote longer survival lack enhancing antibodies, an appropriate balance of two crucial C
Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency.: J Clin Immunol. 1994 May;14(3):149-61. Unique Identifier : AIDSLINE MED/95014860; Chehimi J; Trinchieri G; Children's Hospital of Philadelphia, Pennsylvania.; Interleukin-12 (IL-12) is a disulfide-linked heterodimeric cytokine originally identified as a product of EBV-transformed B cell lines. Monocyte/macrophages are the physiologically most relevant producers of IL-12, in response to both Gram-positive and -negative bacteria, bacterial products, and intracellular parasite
T helper cell dysfunction in systemic lupus erythematosus (SLE): relation to disease activity.: J Clin Immunol. 1994 May;14(3):169-77. Unique Identifier : AIDSLINE MED/95014862; Bermas BL; Petri M; Goldman D; Mittleman B; Miller MW; Stocks NI; Via CS; Shearer GM; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.; Patients with systemic lupus erythematosus (SLE) are known to have defects in both humoral and cellular immunity. The significance of defective T cell-mediated immunity and its relationship to disease activity have not been clearly established. We studied in vitro T helper cell (Th) function in 150 SLE outpatients and
Quantification of human immunodeficiency virus in plasma by RNA PCR, viral culture, and p24 antigen detection.: J Clin Microbiol. 1994 Jul;32(7):1669-73. Unique Identifier : AIDSLINE MED/95014929; Van Kerckhoven I; Fransen K; Peeters M; De Beenhouwer H; Piot P; van der Groen G; Department of Infection and Immunity, Institute of Tropical; Medicine, Antwerp, Belgium.; A semiquantitative PCR technique for detecting human immunodeficiency virus type 1 (HIV-1) RNA in plasma was compared with quantitative viral culture and p24 antigen detection in plasma. Ninety-three samples from 20 symptomatic, 10 asymptomatic, and 10 seronegative individuals were tested. For most of the seropositive
Restriction fragment length polymorphism analysis of clinical isolates of Mycobacterium haemophilum.: J Clin Microbiol. 1994 Jul;32(7):1763-7. Unique Identifier : AIDSLINE GENBANK/X78536; Kikuchi K; Bernard EM; Kiehn TE; Armstrong D; Riley LW; Department of Medicine, Memorial Sloan-Kettering Cancer Center,; New York, New York 10021.; Mycobacterium haemophilum is an emerging opportunistic pathogen, and since 1989, infections caused by this organism have been identified more frequently in the New York City area than in any other region of the United States . A DNA fingerprinting method, based on restriction fragment l
Polyclonal infections due to Mycobacterium avium complex in patients with AIDS detected by pulsed-field gel electrophoresis of sequential clinical isolates.: J Clin Microbiol. 1994 Jul;32(7):1773-8. Unique Identifier : AIDSLINE MED/95014948; Slutsky AM; Arbeit RD; Barber TW; Rich J; von Reyn CF; Pieciak W; Barlow MA; Maslow JN; Infectious Diseases Section, VA Medical Center, Boston,; Massachusetts 02130.; Invasive infection with organisms of the Mycobacterium avium complex (MAC) is common among patients with advanced human immunodeficiency virus infection. In previous studies, we analyzed multiple individual colonies of MAC isolated from specimens obtained at the same time and observed that 14 to 20% of patients are si
Tentative evidence of AIDS-associated biotype of Mycobacterium kansasii.: J Clin Microbiol. 1994 Jul;32(7):1779-82. Unique Identifier : AIDSLINE MED/95014949; Tortoli E; Simonetti MT; Lacchini C; Penati V; Urbano P; Microbiological and Virological Laboratory, Careggi Hospital,; Florence, Italy.; Previous studies revealed heterogeneous behavior within the species Mycobacterium kansasii against commercially available DNA probes (Accuprobe M. kansasii culture identification test; Gen-Probe); several isolates, conventionally identified as M. kansasii, failed in fact to hybridize. Looking for a possible associatio
Pharmacokinetics of zidovudine in HIV-positive patients with liver disease.: J Clin Pharmacol. 1994 Jul;34(7):782-6. Unique Identifier : AIDSLINE MED/95015071; Bareggi SR; Cinque P; Mazzei M; D'Arminio A; Ruggieri A; Pirola R; Nicolin A; Lazzarin A; Department of Pharmacology, School of Medicine, Universita degli; Studi, Milan, Italy.; The pharmacokinetics of zidovudine (ZDV) have been studied in eight AIDS patients with normal liver function, and in four AIDS patients with liver disease. Patients who were previously untreated with ZDV were given 250 mg ZDV, and plasma levels of ZDV and its glucuronic metabolite, GZDV, were determined at 0.5, 1, 1.5
Effects of psoralen plus UVA radiation (PUVA) on HIV-1 in human beings: a pilot study [see comments]: J Am Acad Dermatol. 1994 Nov;31(5 Pt 1):735-40. Unique Identifier : AIDSLINE MED/95015122; Horn TD; Morison WL; Farzadegan H; Zmudzka BZ; Beer JZ; Johns Hopkins Medical Institutions, Department of Dermatology,; Baltimore, MD 21287.; BACKGROUND: Laboratory data document the activation of the HIV-1 genome on exposure to UV radiation, including PUVA. The overall effects of UV radiation exposure on HIV-1 infection in human beings are unknown. OBJECTIVE: Our purpose was to observe CD4 cell counts and quantitative markers of HIV-1 load in late-stage HI
Cutaneous findings in HIV-1-positive patients: a 42-month prospective study. Military Medical Consortium for the Advancement of Retroviral Research (MMCARR) [published errata appear in J Am Acad Dermatol 1995 Jun;32(6):976 and 1995 Aug;33(2 Pt 1):206]: J Am Acad Dermatol. 1994 Nov;31(5 Pt 1):746-54. Unique Identifier : AIDSLINE MED/95015124; Smith KJ; Skelton HG; Yeager J; Ledsky R; McCarthy W; Baxter D; Turiansky GW; Wagner KF; Turianski G [corrected to Turiansky GW]; Walter Reed Army Institute of Research, Bethesda, Maryland.; BACKGROUND: Cutaneous disease is common in patients infected with HIV-1. OBJECTIVE: The aim of our study was to identify cutaneous markers associated with HIV-1 infection and disease progression as measured by Walter Reed (WR) stage. METHODS: For 42 months we have observed 912 HIV-1-positive patients in all WR stages.
Differences in HIV knowledge and attitudes between first- and fourth-year dental students.: J Dent Educ. 1994 Aug;58(8):668-72. Unique Identifier : AIDSLINE MED/95015221; Anderson DG; Call RL; Vojir CP; University of Colorado Health Sciences Center, Mountain-Plains; Regional AIDS Education and Training Center, Denver 80262.
Sensitivity to indirect contacts with other persons: AIDS aversion as a composite of aversion to strangers, infection, moral taint, and misfortune.: J Abnorm Psychol. 1994 Aug;103(3):495-504. Unique Identifier : AIDSLINE MED/95015267; Rozin P; Markwith M; McCauley C; Department of Psychology, University of Pennsylvania,; Philadelphia 19104-6196.; College students and their parents rated their willingness to wear sweaters previously worn by a target person described as having AIDS, another infectious illness (tuberculosis), a misfortune (maimed in automobile accident), moral taint (convicted murderer), or simply as a healthy but unknown man. Parallel ratings we
Specialized home care for patients with AIDS: an experiment in Rotterdam, The Netherlands.: J Adv Nurs. 1994 Jun;19(6):1132-40. Unique Identifier : AIDSLINE MED/95015312; Moons M; Kerkstra A; Biewenga T; Netherlands Institute of Primary Health, Utrecht.; Patients with AIDs are permanently dependent on medical and technical nursing care. During a certain phase of the disease some of the patients have to visit the out-patient clinic of the hospital for regular treatment. It was noticed that AIDS patients find these visits a severe burden. Therefore in Rotterdam an exper
Heterosexuals 'too casual' about AIDS [news]: J Adv Nurs. 1994 Aug;20(2):208. Unique Identifier : AIDSLINE MED/95015354
Prevalence and characteristics of pain in persons with terminal-stage AIDS.: J Adv Nurs. 1994 Aug;20(2):260-8. Unique Identifier : AIDSLINE MED/95015362; Eldridge AD; Severance-Lossin L; Nicholas PK; Leuner JD; Respite Unit, Boston Health Care for the Homeless.; A retrospective chart review was undertaken to collect and report data on the prevalence and characteristics of pain in persons with terminal-stage AIDS. A convenience sample consisting of 50 patient charts at a residential AIDS hospice was utilized. Data were collected from the McCaffery Initial Pain Assessment Tool
Frequency of development of acute global left ventricular dysfunction in human immunodeficiency virus infection.: J Am Coll Cardiol. 1994 Oct;24(4):1018-24. Unique Identifier : AIDSLINE MED/95015412; De Castro S; d'Amati G; Gallo P; Cartoni D; Santopadre P; Vullo V; Cirelli A; Migliau G; Institute of the Sixth Medical Clinic, La Sapienza University,; Rome, Italy.; OBJECTIVES. This study evaluated prospectively the frequency, clinical outcome and pathologic findings of acute global left ventricular dysfunction in human immunodeficiency virus (HIV) infection during the various stages of the disease. BACKGROUND. Acute global left ventricular dysfunction in the course of HIV infect
Myocarditis and cardiotropic viral infection associated with severe left ventricular dysfunction in late-stage infection with human immunodeficiency virus.: J Am Coll Cardiol. 1994 Oct;24(4):1025-32. Unique Identifier : AIDSLINE MED/95015413; Herskowitz A; Wu TC; Willoughby SB; Vlahov D; Ansari AA; Beschorner WE; Baughman KL; Department of Medicine, School of Public Health and Hygiene,; Johns Hopkins Medical Institutions, Baltimore, Maryland.; OBJECTIVES. The purpose of this study was to characterize the histologic and immunopathologic results of 37 endomyocardial biopsy samples from patients infected with human immunodeficiency virus type 1 (HIV-1) who were evaluated for unexplained global left ventricular dysfunction. BACKGROUND. Recent studies have ident
Physiological factors associated with falls in older community-dwelling women.: J Am Geriatr Soc. 1994 Oct;42(10):1110-7. Unique Identifier : AIDSLINE MED/95015564; Lord SR; Ward JA; Williams P; Anstey KJ; Prince of Wales Medical Research Institute, Randwick, NSW,; Australia.; OBJECTIVE: To determine the prevalence of impaired vision, peripheral sensation, lower limb muscle strength, reaction time, and balance in a large community-dwelling population of women aged 65 years and over, and to determine whether impaired performances in these tests are associated with falls. DESIGN: One-year pro
Thalidomide in AIDS: one institution's response to the challenge of an experimental protocol.: J Am Med Wom Assoc. 1994 Jul-Aug;49(4):122-3. Unique Identifier : AIDSLINE MED/95015579; Killip T; Harlow N; Beth Israel Medical Center, New York City.
Detection of the new tuberculosis: ocular examination as a diagnostic imperative.: J Am Optom Assoc. 1994 Jul;65(7):472-9. Unique Identifier : AIDSLINE MED/95015582; Frankel RM; Boname ME; New England College of Optometry, Boston, MA 02115.; BACKGROUND: Until recently, tuberculosis in the U.S. had been considered a public health concern of the past, largely conquered by therapy devised in the 1950s. However, in the past several years, the incidence of tuberculosis has increased steeply and unexpectedly, owing to a conspiracy of new factors. These include:
Lymphoma of the thyroid mimicking thyroiditis in a patient with the acquired immune deficiency syndrome.: J Endocrinol Invest. 1994 Apr;17(4):279-82. Unique Identifier : AIDSLINE MED/95015609; Gochu J; Piper B; Montana J; Park HS; Poretsky L; Department of Medicine, Cabrini Medical Center, New York, New; York 10003.; A 35-year-old man with AIDS and a history of a remission from the lymphoma of the right tonsil (previously treated with chemotherapy and radiation) presented with a variety of clinical, laboratory and radiological findings strongly suggestive of subacute thyroiditis. Fine needle aspiration biopsy failed to establish t
Introduction of a fast and sensitive fluorescent in situ hybridization method for single-copy detection of human papillomavirus (HPV) genome.: J Histochem Cytochem. 1994 Nov;42(11):1503-12. Unique Identifier : AIDSLINE MED/95015784; Siadat-Pajouh M; Ayscue AH; Periasamy A; Herman B; Laboratories for Cell Biology, University of North Carolina,; Chapel Hill 27599.; At present, in situ hybridization (ISH) is the only method for detection of specific genes in morphologically intact cells or tissue. We have developed a highly sensitive and quantitative fluorescence-based in situ hybridization (FISH) technique that can detect as few as one to five copies of the integrated human papi
Thymic development in human CD4 transgenic mice. Positive selection occurs after commitment to the CD8 lineage.: J Immunol. 1994 Oct 15;153(8):3491-503. Unique Identifier : AIDSLINE MED/95015837; Paterson RK; Burkly LC; Kurahara DK; Dunlap A; Flavell RA; Finkel TH; Department of Pediatrics, National Jewish Center for Immunology; and Respiratory Medicine, Denver, CO 80206.; Developing T cells are positively selected on the basis of their recognition of polymorphic MHCs (major histocompatibility molecules). The CD4 and CD8 co-receptors, together with a compatible TCR-alpha beta, bind class II and class I MHC, respectively, delivering a signal that allows T cell maturation to proceed along
Retroviral transduction of protein kinase C-gamma into tumor-specific T cells allows antigen-independent long-term growth in IL-2 with retention of functional specificity in vitro and ability to mediate tumor therapy in vivo.: J Immunol. 1994 Oct 15;153(8):3630-8. Unique Identifier : AIDSLINE MED/95015852; Chen W; Schweins E; Chen X; Finn OJ; Cheever MA; Department of Medicine, University of Washington, Seattle 98195.; The aim of our study was to examine the potential usefulness of transducing the protein kinase C-gamma (PKC-gamma) cDNA gene into tumor-specific T cells as a technique for facilitating the generation of large numbers of functional Ag-specific T for tumor therapy. Murine CD8+, F-MuLV gag-specific CTL clones, and CD4+,
IL-12 regulates T helper type 1 cytokine responses in human infectious disease [published erratum appears in J Immunol 1994 Dec 1;153(11):5347]: J Immunol. 1994 Oct 15;153(8):3639-47. Unique Identifier : AIDSLINE MED/95015853; Sieling PA; Wang XH; Gately MK; Oliveros JL; McHugh T; Barnes PF; Wolf SF; Golkar L; Yamamura M; Yogi Y; et al; Division of Dermatology, University of California-Los Angeles,; School of Medicine 90024.; We investigated the role of IL-12 in regulating T cell and cytokine responses in human infectious disease by using the spectrum of leprosy as a model. Tuberculoid patients mount strong T cell responses to Mycobacterium leprae, with production of the type 1 cytokines IL-2
Lipopolysaccharide-dependent induction of IL-10 receptor expression on murine fibroblasts.: J Immunol. 1994 Oct 15;153(8):3734-44. Unique Identifier : AIDSLINE MED/95015864; Weber-Nordt RM; Meraz MA; Schreiber RD; Department of Pathology, Washington University School of; Medicine, St. Louis, MO 63110.; Although various biologic activities of IL-10 have been identified, little is known about IL-10 s molecular mechanism of action. Herein we report the characterization of IL-10R on different murine cell lines and demonstrate the LPS inducibility of this protein. With the use of purified recombinant murine IL-10 and lab
CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse.: J Immunol. 1994 Oct 15;153(8):3764-74. Unique Identifier : AIDSLINE MED/95015867; Blair PJ; Bultman SJ; Haas JC; Rouse BT; Wilkinson JE; Godfrey VL; Biology Division, Oak Ridge National Laboratory, TN 37831-8077.; Mice hemizygous for the X-linked mutation, scurfy (sf), exhibit a fatal lymphoreticular disease that is mediated by T lymphocytes. To evaluate the respective roles of CD4 or CD8 single positive T cells in scurfy disease, neonates were treated with mAbs directed against the CD4 or CD8 molecules. Whereas mice treated wi
TAT-mediated transcellular activation of HIV-1 long terminal repeat directed gene expression by HIV-1-infected peripheral blood mononuclear cells.: J Immunol. 1994 Oct 15;153(8):3831-9. Unique Identifier : AIDSLINE MED/95015874; Thomas CA; Dobkin J; Weinberger OK; Department of Physiology, Columbia University, New York, NY; 10032.; We have previously shown evidence of Tat-mediated transcellular activation of the HIV-1 long terminal repeat (LTR) in vitro by using a laboratory-adapted strain of HIV-1. To examine the biologic significance of this observation, we asked whether primary PBMCs from HIV-1-infected individuals will transactivate the HIV-
IL-10 inhibits cytokine production, vascular leakage, and swelling during T helper 1 cell-induced delayed-type hypersensitivity.: J Immunol. 1994 Nov 1;153(9):3967-78. Unique Identifier : AIDSLINE MED/95015887; Li L; Elliott JF; Mosmann TR; Department of Immunology, University of Alberta, Edmonton,; Canada.; The Th1 group of cytokines ( IL-2 , IFN-gamma, and lymphotoxin (LT)) is usually associated with delayed-type hypersensitivity (DTH), whereas Th2 cytokines (IL-4, IL-5, IL-6, and IL-10) often accompany Ab production. Strong DTH and Ab responses are often mutually exclusiv
A humanized, bispecific immunoadhesin-antibody that retargets CD3+ effectors to kill HIV-1-infected cells.: J Immunol. 1994 Nov 1;153(9):4268-80. Unique Identifier : AIDSLINE MED/95015917; Chamow SM; Zhang DZ; Tan XY; Mhatre SM; Marsters SA; Peers DH; Byrn RA; Ashkenazi A; Junghans RP; Department of Recovery Sciences, Genentech Inc., South San; Francisco, CA 94080.; HIV infection depletes the immune system of the coordinating functions of CD4+ T cells and APCs, whereas the population of CD8+ CTLs remains largely intact: functional but undirected. We have developed a humanized bispecific immunoadhesin-antibody (BIA) that redirects these remaining T cells to kill HIV-infected cells
Alcian blue-treated polystyrene microtitre plates for use in an ELISA to measure antibodies against synthetic peptides.: J Immunol Methods. 1994 Sep 30;175(1):131-5. Unique Identifier : AIDSLINE MED/95015929; Lagace J; Arsenault S; Cohen EA; Department of Microbiology and Immunology, Universite de; Montreal, Quebec, Canada.; Short peptides often do not bind well to the plastic surface of microtitre wells in solid-phase immunoassays. To improve the reactivity of synthetic peptides coated on the solid phase, we have developed a highly sensitive, rapid and simple ELISA. This ELISA is based on the treatment of microtitre plates with Alcian bl
Analysis of diversity of T cell antigen receptor genes using polymerase chain reaction and sequencing gel electrophoresis.: J Immunol Methods. 1994 Oct 14;175(2):227-36. Unique Identifier : AIDSLINE MED/95015947; Yurovsky VV; Schulze DH; White B; Department of Medicine, University of Maryland School of; Medicine, Baltimore 21201.; A sensitive, highly resolvable, and quantitative method was designed to analyse the diversity of polymerase chain reaction (PCR)-amplified transcripts which possess length polymorphism. A reverse transcriptase-PCR technique was used to amplify rearranged T cell antigen receptor (TCR) transcripts isolated from human bl
Assessment of a positive selection technique using an avidin column to isolate human peripheral blood T cell subsets.: J Immunol Methods. 1994 Oct 14;175(2):247-57. Unique Identifier : AIDSLINE MED/95015949; Davis LS; McIlraith MJ; Paecheo T; Becker B; Adix LM; Thomas R; Wacholtz MC; Lipsky PE; Department of Internal Medicine, University of Texas Southwestern; Medical Center, Dallas 75235-8884.; The current studies were designed to assess a new technique for positively selecting human T cells from whole peripheral blood mononuclear cells using the minimal amount of monoclonal antibody required to bind the T cell to an avidin column indirectly via a biotin-conjugated secondary antibody. Positive selection of T
Simplified conjugation chemistry for coupling peptides to F(ab') fragments: autologous red cell agglutination assay for HIV-1 antibodies.: J Immunol Methods. 1994 Oct 14;175(2):267-73. Unique Identifier : AIDSLINE MED/95015951; Wilson KM; Catimel B; Mitchelhill KI; Kemp BE; St. Vincent's Institute of Medical Research, Fitzroy, Victoria,; Australia.; The rapid whole blood test, developed for the detection of circulating antibodies to human immunodeficiency virus type 1 (HIV-1), is based on agglutination of autologous red blood cells using an anti-human glycophorin antibody conjugated to the HIV-1 immunodominant epitope of gp41 (579-613). A simplified procedure for
AIDS [letter]: J Indian Med Assoc. 1994 Jun;92(6):207. Unique Identifier : AIDSLINE MED/95015964; Mehta BS
Epidermal langerhans cells of AIDS patients express HIV-1 regulatory and structural genes.: J Invest Dermatol. 1994 Oct;103(4):593-6. Unique Identifier : AIDSLINE MED/95015991; Henry M; Uthman A; Ballaun C; Stingl G; Tschachler E; Department of Dermatology, University of Vienna Medical School,; Austria.; In this study we searched for the presence of human immunodeficiency virus (HIV-1)-spliced mRNA in epidermal cells from AIDS patients. Using reverse polymerase chain reaction and Southern hybridization we detected mRNA for HIV-1 regulatory (tat, rev, nef) and structural genes (env) in epidermal cells highly enriched f
AIDS appearance in children is associated with the velocity of disease progression in their mothers.: J Infect Dis. 1994 Oct;170(4):1000-2. Unique Identifier : AIDSLINE MED/95015998; Tovo PA; de Martino M; Gabiano C; Galli L; Tibaldi C; Vierucci A; Veglia F; Department of Pediatrics and Oncologic Gynecology, University of; Turin, Italy.; Thirty-four human immunodeficiency virus type 1 (HIV-1)-infected mother-child pairs were studied from delivery, and the association between velocity of disease progression in mothers and age at AIDS appearance in their children was analyzed. Four maternal disease stages were defined, and the velocity of HIV-1 progress
Effects of antiviral therapy on the production of anti-human immunodeficiency virus-specific immunoglobulin in infants and children.: J Infect Dis. 1994 Oct;170(4):1003-6. Unique Identifier : AIDSLINE MED/95015999; Pollack H; Zhan MX; Moore T; Tao PZ; Krasinski K; Borkowsky W; Department of Pediatrics, New York University Medical Center, NY; 10016.; The effect of zidovudine therapy on human immunodeficiency virus (HIV)-specific antibody production was studied in 64 HIV-1-infected infants and children > 6 months old. HIV-specific in vitro antibody production (IVAP) was measured in cultures of peripheral blood mononuclear cells (PBMC). IVAP decreased in 85% of chil
Prevalence of human T cell lymphotropic virus (HTLV) types I and II and human immunodeficiency virus type 1 infections among persons with Hansen's disease in New York City.: J Infect Dis. 1994 Oct;170(4):1007-9. Unique Identifier : AIDSLINE MED/95016000; Glaser JB; Levis WR; Gruber T; Cabrera A; Poiesz BJ; Division of Infectious Diseases, Staten Island University; Hospital, NY 10305.; One-hundred seven consecutive patients attending a New York Hansen s disease clinic from November 1990 through June 1991 were tested for retroviruses. This cohort included 58 patients diagnosed with Hansen s disease after the onset of the AIDS epidemic, 54 of whom immigrated to the United
Failure of short-term CD4-PE40 infusions to reduce virus load in human immunodeficiency virus-infected persons.: J Infect Dis. 1994 Oct;170(4):1009-13. Unique Identifier : AIDSLINE MED/95016001; Ramachandran RV; Katzenstein DA; Wood R; Batts DH; Merigan TC; Center for AIDS Research, Stanford University Medical Center,; California 94305.; The safety, immunologic, and antiviral effects of a recombinant biologic product that combines the second and third domains of the CD4 molecule and Pseudomonas exotoxin A (PE40) were evaluated in 21 human immunodeficiency virus (HIV)-infected subjects in a phase III open-label dose-ranging study. Subjects with CD4+ ly
Frequent reinfection and reactivation of hepatitis C virus genotypes in multitransfused hemophiliacs.: J Infect Dis. 1994 Oct;170(4):1018-22. Unique Identifier : AIDSLINE MED/95016003; Jarvis LM; Watson HG; McOmish F; Peutherer JF; Ludlam CA; Simmonds P; Department of Medical Microbiology, Medical School, University of; Edinburgh, United Kingdom.; The frequency and dynamics of infection with different genotypes of hepatitis C virus were investigated in a cohort of hemophiliacs repeatedly exposed to non-virus-inactivated clotting factor. Among 63 infected hemophiliacs, genotype 1 (n = 38, subtypes 1a [27] and 1b [11]) was predominant; genotypes 2a (n = 1), 2b (n
Does early zidovudine treatment prevent the emergency of syncytium-inducing human immunodeficiency virus? [letter; comment]: J Infect Dis. 1994 Oct;170(4):1041-2. Unique Identifier : AIDSLINE MED/95016008; Leal M; Torres Y; Medrano FJ; Calderon EJ; Rey C; Lissen E
The serologic significance of F viral genotype for human immunodeficiency virus type 1 epidemic [letter]: J Infect Dis. 1994 Oct;170(4):1043-4. Unique Identifier : AIDSLINE MED/95016010; Cernescu CE; Tardei G; Necula A; Ruta SM; Pau CP
Long-term effects of interleukin-2 on CD4 cell counts in human immunodeficiency virus-infected patients [letter]: J Infect Dis. 1994 Oct;170(4):1044-6. Unique Identifier : AIDSLINE MED/95016011; Ramachandran RV; Katzenstein D; Merigan TC
Candida organisms in dental plaque from AIDS patients [letter]: J Infect Dis. 1994 Oct;170(4):1053-4. Unique Identifier : AIDSLINE MED/95016017; Berthold P; Stewart J; Cumming C; Decker S; MacGregor R; Malamud D
Detection of multiple human papillomavirus types in condylomata acuminata from immunosuppressed patients.: J Infect Dis. 1994 Oct;170(4):759-65. Unique Identifier : AIDSLINE MED/95016020; Brown DR; Bryan JT; Cramer H; Katz BP; Handy V; Fife KH; Department of Medicine, Indiana University School of Medicine,; Indianapolis 46202-5124.; Using the hybrid capture method, condylomata acuminata from healthy patients (controls) and patients with altered cell-mediated immunity were analyzed for multiple human papillomavirus (HPV) DNA: 82.9% and 38.0% of lesions from 41 controls and 21 patients, respectively, were HPV DNA-positive only with probes for low-r
High frequency of Gag- and envelope-specific cytotoxic T lymphocyte precursors in children with vertically acquired human immunodeficiency virus type 1 infection.: J Infect Dis. 1994 Oct;170(4):766-74. Unique Identifier : AIDSLINE MED/95016021; McFarland EJ; Harding PA; Luckey D; Conway B; Young RK; Kuritzkes DR; Department of Medicine, University of Colorado Health Sciences; Center, Children's Hospital, Denver 80262.; Circulating human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocytes (CTL) are seen less frequently in unstimulated peripheral blood mononuclear cells (PBMC) from children with vertically acquired HIV infection than in PBMC from HIV-infected adults. HIV-1 Gag-, reverse transcriptase (RT)-, and enve
CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA-DR+ CD38- CD8+ cells is associated with subsequent stable CD4+ cell levels. The Multicenter AIDS Cohort Study Group.: J Infect Dis. 1994 Oct;170(4):775-81. Unique Identifier : AIDSLINE MED/95016022; Giorgi JV; Ho HN; Hirji K; Chou CC; Hultin LE; O'Rourke S; Park L; Margolick JB; Ferbas J; Phair JP; Department of Medicine, University of California, Los Angeles; (UCLA).; Subsets of activated CD8+ lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became seropositive for human immunodeficiency virus type 1 (HIV). Profound CD8+ cell activation was seen in all subjects at sero
Determinants of antibody response after recombinant gp160 boosting in vaccinia-naive volunteers primed with gp160-recombinant vaccinia virus. The National Institute of Allergy and Infectious Diseases AIDS Vaccine Clinical Trials Network.: J Infect Dis. 1994 Oct;170(4):782-6. Unique Identifier : AIDSLINE MED/95016023; Graham BS; Gorse GJ; Schwartz DH; Keefer MC; McElrath MJ; Matthews TJ; Wright PF; Belshe RB; Clements ML; Dolin R; et al; Dept. of Medicine, Vanderbilt University School of Medicine,; Nashville, TN 37232.; Priming with a live recombinant vector followed by subunit boosting is a promising strategy for human immunodeficiency virus (HIV) immunization. Twenty-nine vaccinia-naive volunteers were primed with gp160-recombinant vaccinia virus (HIVAC-1e) and boosted with recombinant (r) gp160 to define factors associated with th
Host soluble factors with blocking and stimulating activity on the expression of the bovine leukemia virus.: J Infect Dis. 1994 Oct;170(4):787-94. Unique Identifier : AIDSLINE MED/95016024; Zandomeni RO; Esteban E; Carrera-Zandomeni M; Ferrer JF; Comparative Leukemia and Retrovirus Unit, University of; Pennsylvania, Kennett Square 19348.; The bovine leukemia virus (BLV), like the human T cell leukemia viruses (HTLV-I and -II), is usually present in its host in a transcriptionally repressed state. However, the viral genome becomes derepressed a few hours after the infected lymphocytes are cultured in vitro. Depending upon the concentrations tested, plas
Adjunctive folinic acid with trimethoprim-sulfamethoxazole for Pneumocystis carinii pneumonia in AIDS patients is associated with an increased risk of therapeutic failure and death.: J Infect Dis. 1994 Oct;170(4):912-7. Unique Identifier : AIDSLINE MED/95016043; Safrin S; Lee BL; Sande MA; Department of Medicine, University of California, San Francisco.; Ninety-two AIDS patients with Pneumocystis carinii pneumonia (PCP) were randomized to receive folinic acid or matching placebo in conjunction with trimethoprim-sulfamethoxazole in a prospective, double-blind trial. Neither frequency of dose-limiting toxicity (26% vs. 37%; P = .4) nor time to occurrence (P = .7) was as
Blood culture in the first 6 months of life for the diagnosis of vertically transmitted human immunodeficiency virus infection. The Women and Infants Transmission Study Group.: J Infect Dis. 1994 Oct;170(4):996-1000. Unique Identifier : AIDSLINE MED/95016055; McIntosh K; Pitt J; Brambilla D; Carroll S; Diaz C; Handelsman E; Moye J; Rich K; Department of Pediatrics, Children's Hospital, Harvard Medical; School, Boston, Massachusetts.; Serial blood cultures over the first 6 months of life in 310 infants with vertical exposure to human immunodeficiency virus (HIV) in the Women and Infants Transmission Study were analyzed to determine their value for early diagnosis of HIV infection. Cultures were done at 0-7 days and 1, 2, 4, and 6 months of age: 55
Effects of interferon-alpha on a reduced release of interleukin-8 from latently HIV-1-infected monocytic cell line U937 cells.: J Interferon Res. 1994 Jun;14(3):129-32. Unique Identifier : AIDSLINE MED/95016069; Ohashi K; Akazawa R; Kurimoto M; Fujisaki Institute, Hayashibara Biochemical Labs., Inc., Okayama,; Japan.; The effects of human interferon-alpha (IFN-alpha) on the release of an antimicrobial interleukin, interleukin-8 (IL-8), from human immunodeficiency virus type 1 (HIV-1)-infected myelomonocytic cell line, U937, were studied in vitro to evaluate the potential of IFN-alpha in the management of acquired immunodeficiency s
[False positives and false negatives seen in anti-HIV-1 antibody tests]: Kansenshogaku Zasshi. 1994 Aug;68(8):949-52. Unique Identifier : AIDSLINE MED/95016104; Osato K; Matsubayashi T; Nagao T; Inuzumi K; Araki H; Kawai K; Osaka Prefectural Bandai Clinic for STD.; From September 1986 to December 1993 31059 anti-HIV antibody tests were performed on the samples from our clinic, from 29 health centers and their branches of Osaka Prefecture, from a hospital and from high risk groups. Enzyme immune assay (EIA) was used up to 1988 and from 1989 particle agglutination (PA) has been em
Antibodies to 68, 52, and 48 kd proteins of Mycobacterium avium in serum samples from patients with Mycobacterium avium infection.: J Lab Clin Med. 1994 Oct;124(4):546-53. Unique Identifier : AIDSLINE MED/95016220; Rao SP; Catanzaro A; Department of Medicine, Pulmonary and Critical Care Division,; University of California, San Diego.; Mycobacterium avium complex (MAC) is responsible for the highest incidence of disseminated bacterial infection in patients with AIDS. Disease caused by this organism was originally thought to be rare in nonimmunocompromised individuals, but it is now being encountered more frequently. Relatively little is known about
The effect of HIV disease on serum markers of hepatitis delta infection in intravenous drug abusers.: J Lab Clin Med. 1994 Oct;124(4):564-8. Unique Identifier : AIDSLINE MED/95016222; Lake-Bakaar G; Bhat K; Govindarajan S; Department of Medicine, State University of New York Health; Science Center at Brooklyn.; The prevalence of serum markers of delta hepatitis was determined prospectively in 82 intravenous drug abusers at various stages of human immunodeficiency virus (HIV) disease. Seventeen were HIV negative, 30 were HIV positive without acquired immunodeficiency syndrome (AIDS) and 35 had been diagnosed as having AIDS. A
Presentation of endogenous tumor antigens to CD4+ T lymphocytes by murine melanoma cells transfected with major histocompatibility complex class II genes.: J Leukoc Biol. 1994 Oct;56(4):469-74. Unique Identifier : AIDSLINE MED/95016288; Chen PW; Ullrich SE; Ananthaswamy HN; Department of Immunology, The University of Texas M.D. Anderson; Cancer Center, Houston 77030.; In a previous study, we demonstrated that K1735 transfectants expressing either Kk or Ak antigens alone produced tumors in syngeneic mice, whereas transfectants that expressed both antigens were rejected. In this study, we investigated whether K1735 transfectants expressing Ak molecules can present endogenous tumor an
Jacalin, a lectin that inhibits in vitro HIV-1 infection, induces intracellular calcium increase via CD4 in cells lacking the CD3/TcR complex.: J Leukoc Biol. 1994 Oct;56(4):521-4. Unique Identifier : AIDSLINE MED/95016296; Lafont V; Dornand J; d'Angeac AD; Monier S; Alcover A; Favero J; INSERM U65, Universite de Montpellier II, France.; The lectin jacalin interacts with the CD4 cell surface antigen; this lectin inhibits in vitro infection by human immunodeficiency virus type 1 without preventing virus binding on the host cell. The infection process is known to involve cellular events triggered by the binding of the viral external glycoprotein gp120 t
Throwing out the lifelines.: J Med Assoc Ga. 1994 Jul;83(7):391-5. Unique Identifier : AIDSLINE MED/95016321; Kokenes N
Lactic acidosis and acquired immunodeficiency syndrome [letter]: J Intern Med. 1994 Oct;236(4):478-9. Unique Identifier : AIDSLINE MED/95016407; Odeh M
A family of serine proteases expressed exclusively in myelo-monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells.: J Exp Med. 1994 Oct 1;180(4):1445-56. Unique Identifier : AIDSLINE MED/95016436; Franzoso G; Biswas P; Poli G; Carlson LM; Brown KD; Tomita-Yamaguchi M; Fauci AS; Siebenlist UK; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda,; Maryland 20892.; Two groups of U937 promonocytic cells were obtained by limiting dilution cloning which differed strikingly in their ability to support human immunodeficiency virus 1 (HIV-1) replication. Plus clones replicated the virus efficiently, whereas minus clones did not. We examined these clones for differences in nuclear fact
Quantitative analysis of mononuclear cells expressing human immunodeficiency virus type 1 RNA in esophageal mucosa.: J Exp Med. 1994 Oct 1;180(4):1541-6. Unique Identifier : AIDSLINE MED/95016446; Smith PD; Fox CH; Masur H; Winter HS; Alling DW; Department of Medicine, University of Alabama School of Medicine,; Birmingham 35294.; The mucosa of the gastrointestinal tract is presumably an important reservoir for human immunodeficiency virus type 1 (HIV-1), but the level of virus-expressing cells within the mucosa of infected patients is not known. To study this issue, we identified HIV-1 mRNA-expressing (positive) mononuclear cells by in situ hy
Transgenic mice as models of human immunodeficiency virus expression and related cellular effects.: J Gen Virol. 1994 Oct;75 ( Pt 10):2549-58. Unique Identifier : AIDSLINE MED/95016506; Brady HJ; Pennington DJ; Dzierzak EA; Laboratory of Gene Structure and Expression, National Institute; for Medical Research, Mill Hill, London, U.K.
Particle assembly and Vpr expression in human immunodeficiency virus type 1-infected cells demonstrated by immunoelectron microscopy.: J Gen Virol. 1994 Oct;75 ( Pt 10):2607-14. Unique Identifier : AIDSLINE MED/95016512; Wang JJ; Lu Y; Ratner L; Department of Biology and Anatomy, National Defense Medical; Center, Taipei, Taiwan, Republic of China.; The 96 amino acid viral protein R (Vpr) of human immunodeficiency virus type 1 (HIV-1) was detected during virus assembly in intracellular vacuoles and at the plasma membrane on peripheral blood mononuclear cells. In both immature and mature virus particles, Vpr was located immediately beneath the viral envelope, colo
Altered expression of a novel cellular gene as a consequence of integration of human T cell lymphotropic virus type 1.: J Gen Virol. 1994 Oct;75 ( Pt 10):2625-33. Unique Identifier : AIDSLINE GENBANK/X76302; Nakamura Y; Moriuchi R; Nakayama D; Yamashita I; Higashiyama Y; Yamamoto T; Kusano Y; Hino S; Miyamoto T; Katamine S; Department of Bacteriology, Nagasaki University School of; Medicine, Japan.; By analysing a genomic DNA clone derived from the human T cell lymphotropic virus type 1 (HTLV-1)-infected cell line, TL-Su, we found that an integrated HTLV-1 provirus interrupted the poly(A) signal-containing exon of a novel gene, RY-1. Nucleotide sequence analysis of a cDNA derived from Jurkat cells revealed that t
Reactivity of primate sera to foamy virus Gag and Bet proteins.: J Gen Virol. 1994 Oct;75 ( Pt 10):2635-44. Unique Identifier : AIDSLINE GENBANK/X79001; Hahn H; Baunach G; Brautigam S; Mergia A; Neumann-Haefelin D; Daniel MD; McClure MO; Rethwilm A; Institut fur Virologie und Immunbiologie, Universitat; Wurzburg, Germany.; In order to establish criteria for the serodiagnosis of foamy virus infections we investigated the extent to which sera from infected individuals of human and primate origin react with structural and non-structural virus proteins in immunoblot assays. Using lysates from infected cells as the source of virus antigen, a
Origin and evolution of the c-src-transducing avian sarcoma virus PR2257.: J Gen Virol. 1994 Oct;75 ( Pt 10):2777-81. Unique Identifier : AIDSLINE GENBANK/L21974; Yatsula BA; Geryk J; Briestanska J; Karakoz I; Svoboda J; Rynditch AV; Calothy G; Dezelee P; Unite de Recherche Associee 1443 du Centre National de la; Recherche Scientifique, Institut Curie, Orsay, France.; Avian sarcoma virus PR2257 transduced de novo the c-src gene and about 900 bp of 3 non-coding sequences belonging to the src locus. This virus contains only one mutation in the c-src coding sequence causing a reading frame shift after Pro-525. The molecular clone studied was derived from a cell line of transformed qu
Inhibition of feline immunodeficiency virus gene expression and replication by alphaherpesvirus ICP4 homologues.: J Gen Virol. 1994 Oct;75 ( Pt 10):2783-7. Unique Identifier : AIDSLINE MED/95016533; Kawaguchi Y; Maeda K; Miyazawa T; Ono M; Tsubota K; Tomonaga K; Mikami T; Department of Veterinary Microbiology, Faculty of Agriculture,; University of Tokyo, Japan.; We investigated the effects of pseudorabies virus (PRV), herpes simplex virus type 1 (HSV-1), and equine herpesvirus type 1 (EHV-1) ICP4 homologues on feline immunodeficiency virus (FIV) long terminal repeat (LTR)-directed gene expression. This was done by using the transient expression chloramphenicol acetyltransfera
Defective response to T cell mitogens in mice injected with human immunodeficiency virus type 1-infected U937 cells.: J Gen Virol. 1994 Oct;75 ( Pt 10):2789-94. Unique Identifier : AIDSLINE MED/95016534; Ausiello CM; Sestili P; Locardi C; Logozzi M; Rizza P; Parlanti E; Yang L; Modica A; Modesti A; Musiani P; et al; Laboratory of Bacteriology and Medical Mycology, Istituto; Superiore di Sanita, Rome, Italy.; Swiss mice were injected intraperitoneally with uninfected or human immunodeficiency virus type 1 (HIV-1) infected human U937 cells. At 6 days, no residual human cells were detected in mouse tissues as determined by PCR analysis of DNAs from injected mice using primers and probes for the human HLA-DQ alpha gene. At 6
Interleukin 4 and human immunodeficiency virus stimulate LFA-1-ICAM-1-mediated aggregation of monocytes and subsequent giant cell formation.: J Gen Virol. 1994 Oct;75 ( Pt 10):2795-802. Unique Identifier : AIDSLINE MED/95016535; Kazazi F; Chang J; Lopez A; Vadas M; Cunningham AL; Department of Virology, ICPMR, Westmead Hospital, Sydney,; Australia.; The effects of recombinant interleukin 4 (IL-4) on cell cluster and multinucleated giant cell (MGC) formation from human immunodeficiency virus (HIV)-infected and uninfected monocytes were examined. Human blood monocytes were isolated by centrifugal elutriation and monoclonal antibody-complement-dependent lysis of res
Coping with AIDS and the threat of AIDS in intravenous drug abusers.: J Genet Psychol. 1994 Jun;155(2):147-59. Unique Identifier : AIDSLINE MED/95016565; Brook JS; Brook DW; Wynn PS; Whiteman M; Masci JR; de Catalogne J; Roberto J; Amundsen F; Department of Psychiatry and Behavioral Sciences New York Medical; College.; In this investigation of patterns of coping with AIDS or the threat of AIDS by male intravenous drug abusers (both HIV positive and HIV negative), psychosocial measures were used to study the effects of personality factors and social support. Correlational analyses and multiple hierarchical regression analyses were us
The Soriano Award Lecture. Emerging infections of the nervous system.: J Neurol Sci. 1994 Jun;124(1):3-14. Unique Identifier : AIDSLINE MED/95016810; Johnson RT; Department of Neurology, Johns Hopkins University School of; Medicine, Johns Hopkins Hospital, Baltimore, MD 21287.; The epidemic of acquired immunodeficiency disease [AIDS] has focused interest on the origins of new infectious agents. Great plagues are well known from the distant past, but a number of novel diseases affecting the nervous system infections have emerged in recent years. The causes of such new disorders are diverse: w
HTLV-1-associated myelopathy in China. A disease acquired overseas?: J Neurol. 1994 May;241(6):398-400. Unique Identifier : AIDSLINE MED/95016829; Seyfert S; Blum S; Neurologische Klinik, Klinikum Steglitz, Freie Universitat; Berlin, Germany.; This case report documents the first patient from mainland China with an HTLV-1-associated myelopathy. The available epidemiological data suggest a low rate of HTLV1 infection in China, although the surveys are comparatively small. Possible transmission routes and the risk of encoun
Comparative analysis of intrathecal antibody synthesis and DNA amplification for the diagnosis of cytomegalovirus infection of the central nervous system in AIDS patients.: J Neurol. 1994 Jun;241(7):407-14. Unique Identifier : AIDSLINE MED/95016833; Weber T; Beck R; Stark E; Gerhards J; Korn K; Haas J; Luer W; Jahn G; Neurologische Klinik und Poliklinik, Georg-August-Universitat; Gottingen, Germany.; We evaluated 49 paired cerebrospinal fluid (CSF) and serum samples of 35 patients infected with the human immunodeficiency virus type 1 (HIV-1) for laboratory evidence of cytomegalovirus ( CMV ) infection. The patients were gro
Nutritional status and immune responses in mice with murine AIDS are normalized by vitamin E supplementation.: J Nutr. 1994 Oct;124(10):2024-32. Unique Identifier : AIDSLINE MED/95017143; Wang Y; Huang DS; Liang B; Watson RR; Department of Family and Community Medicine, University of; Arizona, Tucson 85724.; Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine AIDS, which is functionally similar to human AIDS. Vitamin E effects on immune functions, cytokine production and nutritional concentrations in retrovirus-infected mice were determined. Retrovirus infection inhibited release of interleukin-2 (IL)
Why have autopsies grown so unpopular and what can we do about it? The clinical-pathological conference! [editorial]: J Okla State Med Assoc. 1994 Aug;87(8):351. Unique Identifier : AIDSLINE MED/95017217; Wlodaver CG
Cocaine abuse in methadone maintenance programs: integrating pharmacotherapy with psychosocial interventions.: J Psychoactive Drugs. 1994 Apr-Jun;26(2):137-46. Unique Identifier : AIDSLINE MED/95017315; Avants SK; Margolin A; Kosten TR; Yale University School of Medicine, Department of Psychiatry, New; Haven, Connecticut 06519.; Cocaine abuse by methadone-maintained patients threatens to undermine the success of methadone programs by sustaining a drug-abusing lifestyle as well as contributing to the spread of HIV. The search for a pharmacotherapeutic agent for the treatment of cocaine has met with limited success. The most promising results e
Effectiveness of streamlined admissions to methadone treatment: a simplified time-series analysis.: J Psychoactive Drugs. 1994 Apr-Jun;26(2):207-16. Unique Identifier : AIDSLINE MED/95017322; Dennis ML; Ingram PW; Burks ME; Rachal JV; Center for Social Research and Policy Analysis, Research Triangle; Institute, Research Triangle Park, North Carolina 27709-2194.; Increasing the availability of, and streamlining the admissions process to, methadone treatment have consistently been the focus of national plans to address the acquired immune deficiency syndrome (AIDS) epidemic. This article uses simplified time-series analysis to evaluate one of the first methadone treatment Waiti
Retention of patients who entered methadone maintenance via an interim methadone clinic.: J Psychoactive Drugs. 1994 Apr-Jun;26(2):217-21. Unique Identifier : AIDSLINE MED/95017323; Friedman P; Des Jarlais DC; Peyser NP; Nichols SE; Drew E; Newman RG; Chemical Dependency Institute, Beth Israel Medical Center, New; York, New York 10003.; Time in treatment is considered an important predictor of good outcomes for drug abuse treatment. Patient retention would be of particular concern for low-service types of treatment. Interim methadone maintenance was developed as an alternative to waiting lists and as a method of providing HIV risk-reduction services
Reasons for discharge from methadone maintenance for addicts at high risk of HIV infection or transmission.: J Psychoactive Drugs. 1994 Apr-Jun;26(2):223-32. Unique Identifier : AIDSLINE MED/95017324; Grella CE; Anglin MD; Wugalter SE; Rawson R; Hasson A; UCLA Drug Abuse Research Center 90024.; This article reports on a methadone maintenance program that had the goal of retaining in treatment heroin addicts at high risk of HIV infection and/or transmission. Subjects were recruited from four-high-risk target groups and randomly assigned to either an enhanced or standard methadone maintenance group. The analys
Limitations of fractional shortening as an index of contractility in pediatric patients infected with human immunodeficiency virus.: J Pediatr. 1994 Oct;125(4):563-70. Unique Identifier : AIDSLINE MED/95017332; Lipshultz SE; Orav EJ; Sanders SP; McIntosh K; Colan SD; Department of Cardiology, Children's Hospital, Boston, MA 02115.; Left ventricular fractional shortening (FS) is dependent on left ventricular preload and afterload, as well as contractility. Contractility may therefore not be accurately described by FS, especially in infants and children infected with human immunodeficiency virus (HIV), who tend to have abnormal left ventricular pr
AIDS and intravenous drug use: a growing menace.: J Drug Educ. 1994;24(2):133-8. Unique Identifier : AIDSLINE MED/95017384; Zapata V; Blanton C; Department of Health Science, California State University, Los; Angeles 90032.; The AIDS virus is transmitted through the exchange of bodily fluids between an infected person and an uninfected person, and the sharing of needles by IV drug users has been one of the primary means of transmission. The incidence of infection by this method has increased in the world, and in the inner cities of the
Academic, behavioral, and social adaptation of boys with hemophilia/HIV disease.: J Pediatr Psychol. 1994 Aug;19(4):457-73. Unique Identifier : AIDSLINE MED/95017393; Colegrove RW Jr; Huntzinger RM; University of Southern California School of Medicine.; Examined the intelligence, academic achievement, behavior, and social competency of 37 school-aged boys with hemophilia, 56% with HIV infection. IQ scores fell in the average range, but total reading scores were almost 1 standard deviation below the mean. Parent and teacher ratings of social functioning and behavior f
A neurotic lawyer: AIDS or Oedipus?: J Pers Assess. 1994 Aug;63(1):10-26. Unique Identifier : AIDSLINE MED/95017487; Peterson CA; Veterans Administration, Minneapolis, MN 55417.
Wild-type and mutant HIV-1 and HIV-2 Tat proteins expressed in Escherichia coli as fusions with glutathione S-transferase.: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1116-21. Unique Identifier : AIDSLINE MED/95017542; Rhim H; Echetebu CO; Herrmann CH; Rice AP; Division of Molecular Virology, Baylor College of Medicine,; Houston, Texas 77030.; Human immunodeficiency virus type 1 (HIV-1) and HIV-2 encode related transcriptional activators known as Tat-1 and Tat-2, respectively, that are required for efficient viral replication. The Tat proteins have been studied extensively, and it appears that their mechanism of action is unique to the primate immunodeficie
The effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in HIV-seropositive persons.: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1122-33. Unique Identifier : AIDSLINE MED/95017543; Ullum H; Palmo J; Halkjaer-Kristensen J; Diamant M; Klokker M; Kruuse A; LaPerriere A; Pedersen BK; Copenhagen Muscle Research Center, Department of Infectious; Diseases, Rigshospitalet, Denmark.; Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4+, CD4+45RA+, and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold
Initial assessment of patients infected with human immunodeficiency virus: the yield and cost of laboratory testing.: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1134-40. Unique Identifier : AIDSLINE MED/95017544; Freedberg KA; Malabanan A; Samet JH; Libman H; Department of Medicine, Boston City Hospital, MA 02118.; Our objective was to determine the yield and cost of standardized laboratory testing of HIV-infected patients entering medical care after testing positive for HIV. An HIV staging and referral clinic in a municipal public hospital was our site for a cross-sectional study, and 308 patients were evaluated in the clinic b
Treatment of experimental Toxoplasma gondii infection by clarithromycin-based combination therapy with minocycline or pyrimethamine.: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1141-8. Unique Identifier : AIDSLINE MED/95017545; Alder J; Hutch T; Meulbroek JA; Clement JC; Department of Anti-infective Microbiology, Abbott Laboratories,; Abbott Park, Illinois 60064-3500.; The efficacy of clarithromycin combined with either pyrimethamine or minocycline for treatment of experimental Toxoplasma gondii infection was investigated. Mice were infected intraperitoneally with 2 x 10(3) to 2 x 10(4) T. gondii strain RH or TS4 tachyzoites. Mortality was recorded for 35 days postinfection. Latency
Decreased plasma concentrations of HDL cholesterol in HIV-infected individuals are associated with immune activation.: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1149-56. Unique Identifier : AIDSLINE MED/95017546; Zangerle R; Sarcletti M; Gallati H; Reibnegger G; Wachter H; Fuchs D; Department of Dermatology and Venereology, University of; Innsbruck, Austria.; We investigated 63 individuals with HIV infection, 34 of whom were asymptomatic (nine had oral candidiasis, four had constitutional signs and symptoms, and 16 had AIDS), for plasma lipids, soluble tumor necrosis factor receptor 75 (sTNF-R75) and other immune activation markers, namely urinary neopterin, beta 2-microgl
Natural history of HIV infection in Filipino female commercial sex workers.: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1157-68. Unique Identifier : AIDSLINE MED/95017547; Manaloto CR; Perrault JG; Caringal LT; Santiago EG; Wignall FS; Gonzales VL; Anthony RL; Hayes CG; U.S. Naval Medical Research Unit No. 2 Detachment, Manila,; Philippines.; A prospective follow-up study of the progression of HIV infection, from seroconversion to onset of opportunistic infections (OI) indicative of immune deficiency and to death, was performed in a cohort of 54 HIV-1 antibody positive Filipino female commercial sex workers (FCSW). The cumulative probability of having a CD
Role of the primary infection in epidemics of HIV infection in gay cohorts [see comments]: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1169-84. Unique Identifier : AIDSLINE MED/95017548; Jacquez JA; Koopman JS; Simon CP; Longini IM Jr; Department of Physiology, University of Michigan, Ann Arbor; 48109-0622.; A review of the data on infectivity per contact for transmission of the HIV suggests that the infectivity may be on the order of 0.1-0.3 per anal intercourse in the period of the initial infection, 10(-4) to 10(-3) in the long asymptomatic period, and 10(-3) to 10(-2) in the period leading into AIDS. The pattern of hi
A review of human immunodeficiency virus infection in India.: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1185-94. Unique Identifier : AIDSLINE MED/95017549; Jain MK; John TJ; Keusch GT; Department of Virology and Microbiology, Christian Medical; College, Vellore, India.; By the turn of the century 20-50 million adults are projected to be HIV positive in Asia, and India will have the largest burden of newly infected patients in a single country. To determine the present status of the epidemic, a systematic review of available data in India has been c
The seroepidemiology of human immunodeficiency virus in the United States household population: NHANES III, 1988-1991.: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1195-201. Unique Identifier : AIDSLINE MED/95017550; McQuillan GM; Khare M; Ezzati-Rice TM; Karon JM; Schable CA; Murphy RS; Division of Health Examination Statistics, National Center for; Health Statistics, Hyattsville, MD 20782.; To provide an estimate of the seroprevalence of human immunodeficiency virus (HIV) in a representative sample of the U.S. household population, serum samples from participants in the third National Health and Nutrition Examination Survey (NHANES III) were tested for HIV antibody. The testing was performed anonymously
AIDS-associated Kaposi's sarcoma and non-Hodgkin's lymphomas reporting in Italy: a linkage study.: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1202-7. Unique Identifier : AIDSLINE MED/95017551; Serraino D; Franceschi S; Greco D; Carbone A; Monfardini S; Tirelli U; Epidemiology Unit, Aviano Cancer Centre, Italy.; To evaluate the completeness and accuracy in the reporting of AIDS-associated Kaposi s sarcoma (KS) and non-Hodgkin s lymphomas (NHL) in Italy , a linkage study of the notifications to the Italian AIDS Registry (RAIDS--the national compulsory AIDS surveillance system) and the clinica
Modulation of host cell growth during FIV infection in vitro [letter]: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1208-10. Unique Identifier : AIDSLINE MED/95017552; Piedimonte G; Corradi A; Cabassi E; Moraillon A; Eloit M; Parodi AL
Epiglottitis as a manifestation of acute HIV infection [letter]: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1210-1. Unique Identifier : AIDSLINE MED/95017553; Pedersen BK; Pedersen C
HIV-1 infection in multi-transfused thalassemic Indian children [letter]: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1211. Unique Identifier : AIDSLINE MED/95017554; Kumar RM; Uduman S; Khurranna A
Dentists and AIDS: a survey of knowledge, attitudes, and behavior in Italy.: J Public Health Dent. 1994 Summer;54(3):145-52. Unique Identifier : AIDSLINE MED/95017829; Angelillo IF; Villari P; D'Errico MM; Grasso GM; Ricciardi G; Pavia M; Medical School University of Reggio Calabria, Catanzaro, Italy.; OBJECTIVES: Italy , together with Spain , is second only to France in the total number of AIDS cases in Europe, with over 16,800 as of March 1993. The purpose of this study was to evaluate knowledge, attitudes, a
RS3PE syndrome: no evidence for retroviruses.: J Rheumatol. 1994 Jun;21(6):1105-6. Unique Identifier : AIDSLINE MED/95017906; Russell EB; McCarty DJ; Schwab J; Hanel D; Komorowski R; Stransky G; Gay S; Department of Medicine, Medical College of Wisconsin, Milwaukee; 53226.; OBJECTIVE. To determine whether human T cell lymphotrophic virus (HTLV) infection is associated with remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome. METHODS. Three patients presenting with RS3PE syndrome and 7 controls were examined for the presence of HTLV crossreactive antigens. RES
Intrinsic spinal cord lesions in 2 patients with ankylosing spondylitis.: J Rheumatol. 1994 Jun;21(6):1160-1. Unique Identifier : AIDSLINE MED/95017920; Dolan AL; Gibson T; Department of Rheumatology, Guy's Hospital, London, UK.; Two men with longstanding ankylosing spondylitis (AS) developed spastic paraparesis. Extensive investigation failed to find a cause and it was concluded that some acute undetermined intrinsic spinal cord lesion had occurred. Similar descriptions in the past have been attributed to associated multiple sclerosis, but we
Salmonella septic arthritis in patients with human immunodeficiency virus [letter; comment]: J Rheumatol. 1994 Jun;21(6):1172-3. Unique Identifier : AIDSLINE MED/95017927; Olive AT; Tena X
Empyema thoracis in AIDS [letter]: J R Soc Med. 1994 Sep;87(9):570. Unique Identifier : AIDSLINE MED/95017960; Hornick P; Smith PL
Is the prescription of amphetamine justified as a harm reduction measure?: J R Soc Health. 1994 Jun;114(3):127-31. Unique Identifier : AIDSLINE MED/95017968; Fleming PM; Roberts D; Drug Advice Centre, Cosham, Portsmouth, Hampshire.; Although amphetamine is the most widely illicitly used drug in the United Kingdom after cannabis, relatively few problematic users present to treatment agencies. Injecting amphetamine users are a high risk group as far as HIV transmission is concerned. This paper reviews the first 3 ye
Mother-child transmission of HIV [news]: J R Soc Health. 1994 Aug;114(4):176. Unique Identifier : AIDSLINE MED/95017979
Urban Tb [news]: J R Soc Health. 1994 Aug;114(4):176. Unique Identifier : AIDSLINE MED/95017980
Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction.: J Med Chem. 1994 Sep 16;37(19):3040-50. Unique Identifier : AIDSLINE MED/95018013; Cushman M; Golebiewski WM; McMahon JB; Buckheit RW Jr; Clanton DJ; Weislow O; Haugwitz RD; Bader JP; Graham L; Rice WG; Department of Medicinal Chemistry and Pharmacognosy, School of; Pharmacy and Pharmacal Sciences, Purdue University, West; Lafayette, Indiana 47907.; Cosalane (3), a novel anti-HIV agent having a disalicylmethane unit linked to C-3 of cholestane by a three-carbon linker, was synthesized from commercially available starting materials by a convergent route. Cosalane proved to be a potent inhibitor of HIV with a broad range of activity against a variety of laboratory,
Inhibitors of HIV-1 proteinase containing 2-heterosubstituted 4-amino-3-hydroxy-5-phenylpentanoic acid: synthesis, enzyme inhibition, and antiviral activity.: J Med Chem. 1994 Sep 16;37(19):3079-89. Unique Identifier : AIDSLINE MED/95018018; Scholz D; Billich A; Charpiot B; Ettmayer P; Lehr P; Rosenwirth B; Schreiner E; Gstach H; Department of Antiretroviral Therapy, SANDOZ Forschungsinstitut; Ges.m.b.H., Vienna, Austria.; A convenient procedure for the synthesis of 2-heterosubstituted statine derivatives as novel building blocks in HIV- protease inhibitors has been developed. The synthesis starts with protected L-phenylalaninols, which were converted to gamma-amino alpha, beta-unsatur
Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'--P2' amide bond isostere.: J Med Chem. 1994 Sep 16;37(19):3100-7. Unique Identifier : AIDSLINE MED/95018020; Thompson SK; Murthy KH; Zhao B; Winborne E; Green DW; Fisher SM; DesJarlais RL; Tomaszek TA Jr; Meek TD; Gleason JG; et al; Department of Medicinal Chemistry, SmithKline Beecham; Pharmaceuticals, King of Prussia, Pennsylvania 19406.; The rational design and synthesis of a highly potent inhibitor of HIV-1 protease have been accomplished. The inhibitor, SB 206343, is based on a model derived from the structure of the MVT-101/HIV-1 protease complex and contains a 4(5)-acylimidazole ring as an isosteric replacement for the P1 --P2 amide bond. It is a
Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors.: J Med Chem. 1994 Sep 30;37(20):3200-4. Unique Identifier : AIDSLINE MED/95018033; Thaisrivongs S; Tomich PK; Watenpaugh KD; Chong KT; Howe WJ; Yang CP; Strohbach JW; Turner SR; McGrath JP; Bohanon MJ; et al; Medicinal Chemistry Research, Upjohn Laboratories, Kalamazoo,; Michigan 49001.
Conformationally locked nucleoside analogues. Synthesis of dideoxycarbocyclic nucleoside analogues structurally related to neplanocin C.: J Med Chem. 1994 Sep 30;37(20):3389-99. Unique Identifier : AIDSLINE MED/95018055; Rodriguez JB; Marquez VE; Nicklaus MC; Mitsuya H; Barchi JJ Jr; Laboratory of Medicinal Chemistry, National Cancer Institute,; NIH, Bethesda, Maryland 20892.; The glycon moiety of nucleosides in solution is known to exist in a rapid dynamic equilibrium between extreme northern and southern conformations as defined by the pseudorotation cycle. The concept of preparing rigid nucleoside analogues with the glycon conformation locked in one of these two extremes was tested with
L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor.: J Med Chem. 1994 Oct 14;37(21):3443-51. Unique Identifier : AIDSLINE MED/95018061; Dorsey BD; Levin RB; McDaniel SL; Vacca JP; Guare JP; Darke PL; Zugay JA; Emini EA; Schleif WA; Quintero JC; et al; Department of Medicinal Chemistry, Merck Research Laboratories,; West Point, Pennsylvania 19486.; A series of HIV protease inhibitors possessing a hydroxylaminepentanamide transition state isostere have been developed. Incorporation of a basic amine into the backbone of the L-685,434 (2) series provided antiviral potency combined with a highly improved pharmacok
Synthesis and antiviral (HIV-1, HBV) activities of 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidine diastereomers. Potential prodrugs to 3'-fluoro-3'-deoxythymidine.: J Med Chem. 1994 Oct 14;37(21):3554-60. Unique Identifier : AIDSLINE MED/95018073; Kumar R; Wang L; Wiebe LI; Knaus EE; Faculty of Pharmacy and Pharmaceutical Sciences, University of; Alberta, Edmonton, Canada.; A new class of 5-halo-6-methoxy(or azido)-5,6-dihydro-3 -fluoro-3 - deoxythymidines (4-13) were investigated as potential anti-AIDS drugs. These 5,6-dihydro derivatives, which are also potential prodrugs to 3 -fluoro-3 -deoxythymidine (FLT), were designed to have properties which would enhance their duration of action
Sexual transmission of SIVagm in wild grivet monkeys.: J Med Primatol. 1994 Jan;23(1):1-7. Unique Identifier : AIDSLINE MED/95018141; Phillips-Conroy JE; Jolly CJ; Petros B; Allan JS; Desrosiers RC; Department of Anatomy and Neurobiology, Washington University; School of Medicine, St. Louis, MO.; This study reports the prevalence of simian immunodeficiency virus and the relationship of serostatus to age and sex among a wild population of Ethiopian grivet monkeys (Cercopithecus aethiops aethiops). Seropositivity paralleled patterns of sexual activity, being nearly universal in females of reproductive age, and a
Chimpanzees in AIDS research: a biomedical and bioethical perspective.: J Med Primatol. 1994 Jan;23(1):49-51. Unique Identifier : AIDSLINE MED/95018147; van Akker R; Balls M; Eichberg JW; Goodall J; Heeney JL; Osterhaus AD; Prince AM; Spruit I; Ministry of Education and Science, Zoetermeer, The Netherlands.; The present article represents a consensus view of the appropriate utilization of chimpanzees in AIDS research arrived at as a result of a meeting of a group of scientists involved in AIDS research with chimpanzees and bioethicists. The paper considers which types of studies are scientifically justifiable in this spec
Spontaneous renal lymphosarcoma in a juvenile cynomolgus monkey (Macaca fascicularis).: J Med Primatol. 1994 Jan;23(1):56-7. Unique Identifier : AIDSLINE MED/95018149; Anderson WI; Inhelder JL; King NW JR; Department of Pathology, Wyeth-Ayerst Research, Chazy, NY 12921.; Spontaneous lymphosarcoma, likely of renal origin, was diagnosed in a naive, juvenile, male cynomolgus monkey (Macaca fascicularis). Histologically, renal architecture was effaced by dense infiltrating sheets of plump cells with indistinct borders and scant amphophilic cytoplasm. Mitoses were uncommon. Similar neoplas
Amino acid requirements of the nucleocapsid protein of HIV-1 for increasing catalytic activity of a Ki-ras ribozyme in vitro.: J Mol Biol. 1994 Sep 30;242(4):422-9. Unique Identifier : AIDSLINE MED/95018209; Muller G; Strack B; Dannull J; Sproat BS; Surovoy A; Jung G; Moelling K; Max-Planck-Institut fur Molekulare Genetik, Berlin (Dahlem),; FRG.; The nucleocapsid protein NCp7 of HIV-1 is a single-stranded nucleic acid binding protein with several functions such as specific recognition, dimerization and packaging of viral RNA, tRNA annealing to viral RNA and protection against nucleases. Since some of these functions involve annealing and double-stranded RNA-me
Interaction between tumour necrosis factor alpha ribozyme and cellular proteins. Involvement in ribozyme stability and activity.: J Mol Biol. 1994 Oct 7;242(5):619-29. Unique Identifier : AIDSLINE MED/95018229; Sioud M; Institute of Immunology and Rheumatology, Rikshospitalet, Oslo,; Norway.; Ribozymes are RNA molecules that cleave other RNA molecules. Thus, ribozymes offer a new way of inhibiting expression of specific genes whose nucleotide sequences are known. Intracellular stability of ribozymes is an important factor for their efficacy. We previously showed that hammerhead ribozyme directed against mR
Postoperative infections in asymptomatic HIV-seropositive orthopedic trauma patients.: J Trauma. 1994 Oct;37(4):545-50; discussion 550-1. Unique Identifier : AIDSLINE MED/95018407; Paiement GD; Hymes RA; LaDouceur MS; Gosselin RA; Green HD; Department of Orthopedic Surgery University of California, San; Francisco General Hospital 94110.; In a retrospective study of 476 surgical orthopedic trauma patients, we compared postoperative infection rates between individuals seropositive for the human immunodeficiency virus (HIV) and with no associated clinical symptoms with HIV-seronegative patients. Overall, the surgical postoperative infection rate was 16.7
Hepatobiliary abnormalities on sonography in children with HIV infection.: J Ultrasound Med. 1994 Mar;13(3):205-10. Unique Identifier : AIDSLINE MED/95018502; Chung CJ; Sivit CJ; Rakusan TA; Chandra RS; Ellaurie M; Department of Diagnostic Imaging and Radiology, Children's; National Medical Center, Washington, DC 20010.; Our purpose was to characterize the spectrum of hepatobiliary abnormalities on sonography in children with vertically transmitted HIV infection. Abdominal sonograms were performed on 41 children with HIV infection and correlated with clinical and histopathologic data. Hepatobiliary abnormalities were noted in 26 (63%)
Non-Hodgkin's lymphoma mimicking a scrotal abscess in a patient with AIDS.: J Ultrasound Med. 1994 Sep;13(9):715-8. Unique Identifier : AIDSLINE MED/95018574; Korn RL; Langer JE; Nisenbaum HL; Miller WT Jr; Cheung LP; Department of Radiology, University of Pennsylvania Medical; Center, Philadelphia.
Molecular biology of the human immunodeficiency virus accessory proteins.: J Virol. 1994 Nov;68(11):6831-5. Unique Identifier : AIDSLINE MED/95018589; Subbramanian RA; Cohen EA; Department of Microbiology and Immunology, Faculty of Medicine,; University of Montreal, Quebec, Canada.
Immunological evidence for interactions between the first, second, and fifth conserved domains of the gp120 surface glycoprotein of human immunodeficiency virus type 1.: J Virol. 1994 Nov;68(11):6836-47. Unique Identifier : AIDSLINE MED/95018590; Moore JP; Willey RL; Lewis GK; Robinson J; Sodroski J; Aaron Diamond AIDS Research Center, New York University School of; Medicine, New York 10016.; We have used a combination of genetic and immunological techniques to explore how amino acid substitutions in the second conserved (C2) domain of gp120 from human immunodeficiency virus type 1 (HIV-1) affect the conformation of the protein. It was reported previously (R. L. Willey, E. K. Ross, A. J. Buckler-White, T.
Interference of interleukin-10 with human immunodeficiency virus type 1 replication in primary monocyte-derived macrophages.: J Virol. 1994 Nov;68(11):6967-75. Unique Identifier : AIDSLINE MED/95018604; Kootstra NA; van 't Wout A; Huisman HG; Miedema F; Schuitemaker H; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam.; Previously we demonstrated an inhibitory effect of interleukin-4 (IL-4) on establishment of human immunodeficiency virus type 1 (HIV-1) infection in primary macrophages. The reported similarities between the biological effects of IL-4 and IL-10 prompted us to study the effect of IL-10 on HIV-1 replication. Treatment o
Molecular cloning and characterization of an immunosuppressive and weakly oncogenic variant of Friend murine leukemia virus, FIS-2.: J Virol. 1994 Nov;68(11):6976-84. Unique Identifier : AIDSLINE GENBANK/Z35111; Dai HY; Faxvaag A; Troseth GI; Aarset H; Dalen A; Unigen Center for Molecular Biology, University of Trondheim,; Norway.; The FIS variant is a weakly leukemogenic, relatively strong immunosuppressive murine retrovirus which was isolated from the T helper cells of adult NMRI mice infected with Friend murine leukemia virus (F-MuLV) complex (FV). Unlike FV, it does not induce acute erythroleukemia but retains the immunosuppressive property
Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D.: J Virol. 1994 Nov;68(11):6994-7000. Unique Identifier : AIDSLINE MED/95018607; Conley AJ; Gorny MK; Kessler JA 2nd; Boots LJ; Ossorio-Castro M; Koenig S; Lineberger DW; Emini EA; Williams C; Zolla-Pazner S; Department of Antiviral Research, Merck Research Laboratories,; West Point, Pennsylvania 19486.; Human monoclonal antibody 447-52D binds to the V3 determinant of the human immunodeficiency virus type 1 (HIV-1) gp120 external glycoprotein. Its binding requires the expression of the GPxR sequence at the center of the V3 domain. HIV-1 variants that are adapted to replication in T-lymphoid cell lines and express this
La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA.: J Virol. 1994 Nov;68(11):7001-7. Unique Identifier : AIDSLINE MED/95018608; Svitkin YV; Pause A; Sonenberg N; Department of Biochemistry, McGill University, Montreal, Quebec,; Canada.; The trans-activation response element (TAR) at the 5 end of the human immunodeficiency virus type 1 (HIV-1) mRNAs forms a stable hairpin structure which is a target for binding of the virally encoded protein Tat, which activates viral gene expression, as well as several cellular factors. TAR is also inhibitory to tra
Direct interactions between autoantigen La and human immunodeficiency virus leader RNA [published erratum appears in J Virol 1995 Jan;69(1):618]: J Virol. 1994 Nov;68(11):7008-20. Unique Identifier : AIDSLINE MED/95018609; Chang YN; Kenan DJ; Keene JD; Gatignol A; Jeang KT; Molecular Virology Section, National Institute of Allergy and; Infectious Diseases, NIH, Bethesda, MD 20892.; We have characterized the in vivo and in vitro binding of human La protein to the human immunodeficiency virus type 1 (HIV-1) leader RNA, the trans-activation response element (TAR). In immunoprecipitation studies using anti-La serum, La-TAR ribonucleoproteins were recovered from HIV-1-infected lymphocytes. Further ch
A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge.: J Virol. 1994 Nov;68(11):7021-9. Unique Identifier : AIDSLINE MED/95018610; Lohman BL; McChesney MB; Miller CJ; McGowan E; Joye SM; Van Rompay KK; Reay E; Antipa L; Pedersen NC; Marthas ML; Department of Medicine, University of California--Davis 95616.; Three infectious, attenuated molecular clones of simian immunodeficiency virus (SIVmac) were tested for viral and host determinants of protective immunity. The viruses differed in degree of virulence from highly attenuated to moderately attenuated to partially attenuated. Levels of immune stimulation and antiviral imm
Improved self-inactivating retroviral vectors derived from spleen necrosis virus.: J Virol. 1994 Nov;68(11):7060-6. Unique Identifier : AIDSLINE MED/95018614; Olson P; Nelson S; Dornburg R; Department of Molecular Genetics and Microbiology, Robert Wood; Johnson Medical School, University of Medicine and Dentistry of; New Jersey, Piscataway 08854.; Self-inactivating (SIN) retroviral vectors contain a deletion spanning most of the right long terminal repeat s (LTR s) U3 region. Reverse transcription copies this deletion to both LTRs. As a result, there is no transcription from the 5 LTR, preventing further replication. Many previously developed SIN vectors, howe
Expression of human immunodeficiency virus type 1 in the nervous system of transgenic mice leads to neurological disease.: J Virol. 1994 Nov;68(11):7099-107. Unique Identifier : AIDSLINE MED/95018619; Thomas FP; Chalk C; Lalonde R; Robitaille Y; Jolicoeur P; Laboratory of Molecular Biology, Clinical Research Institute of; Montreal, Quebec, Canada.; Patients infected with the human immunodeficiency virus type 1 (HIV-1) frequently develop central and peripheral nervous system complications, some of which may reflect the effect of the virus itself. In order to elucidate the pathogenic mechanisms of HIV in neurological disease in a small animal model, we generated t
An amphipathic peptide from the C-terminal region of the human immunodeficiency virus envelope glycoprotein causes pore formation in membranes.: J Virol. 1994 Nov;68(11):7115-23. Unique Identifier : AIDSLINE MED/95018621; Chernomordik L; Chanturiya AN; Suss-Toby E; Nora E; Zimmerberg J; Laboratory of Theoretical and Physical Biology, National; Institute of Child Health and Human Development, National; Institutes of Health, Bethesda, Maryland 20892.; The peptide fragment of the carboxy-terminal region of the human immunodeficiency virus (HIV) transmembrane protein (gp41) has been implicated in T-cell death. This positively charged, amphipathic helix (amino acids 828 to 848) of the envelope protein is located within virions or cytoplasm. We studied the interaction
Antibody reactivity to the immunodominant epitopes of the caprine arthritis-encephalitis virus gp38 transmembrane protein associates with the development of arthritis.: J Virol. 1994 Nov;68(11):7139-47. Unique Identifier : AIDSLINE MED/95018624; Bertoni G; Zahno ML; Zanoni R; Vogt HR; Peterhans E; Ruff G; Cheevers WP; Sonigo P; Pancino G; Institute of Veterinary Virology, University of Berne,; Switzerland.; High titers of antibodies to caprine arthritis-encephalitis virus (CAEV) envelope (Env) glycoproteins are found in infected goats developing a progressive arthritis. In order to identify linear B epitopes of the CAEV Env, which may be involved in the immunopathology of arthritis, we constructed a lambda gt11 Env expre
Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.: J Virol. 1994 Nov;68(11):7188-99. Unique Identifier : AIDSLINE GENBANK/S73885; Ou SH; Garcia-Martinez LF; Paulssen EJ; Gaynor RB; Department of Medicine, University of Texas Southwestern Medical; Center at Dallas 75235-8594.; Human immunodeficiency virus type 1 (HIV-1) gene expression is dependent on a number of cis-acting DNA elements present in the HIV-1 long terminal repeat. Previous studies have demonstrated that the TATA element is critical for basal and Tat-induced HIV-1 gene expression. The HIV-1 TATA region has an unusual structure
High incidence of HAM/TSP-like symptoms in WKA rats after administration of human T-cell leukemia virus type 1-producing cells.: J Virol. 1994 Nov;68(11):7221-6. Unique Identifier : AIDSLINE MED/95018632; Kushida S; Mizusawa H; Matsumura M; Tanaka H; Ami Y; Hori M; Yagami K; Kameyama T; Tanaka Y; Yoshida A; et al; Institute of Basic Medical Sciences, University of Tsukuba,; Ibaraki, Japan.; We demonstrate a significantly high incidence of human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM)-or tropical spastic paraparesis (TSP)-like symptoms in WKA rats after injection with HTLV-1-producing MT-2 cells, while no symptoms were observed in F344 rats injected with MT-2 cells or in control
Serum response factor has functional roles both in indirect binding to the CArG box and in the transcriptional activation function of human T-cell leukemia virus type I Tax.: J Virol. 1994 Nov;68(11):7275-83. Unique Identifier : AIDSLINE MED/95018639; Fujii M; Tsuchiya H; Chuhjo T; Minamino T; Miyamoto K; Seiki M; Department of Molecular Virology and Oncology, Kanazawa; University, Ishikawa, Japan.; We previously reported that Tax1 of human T-cell leukemia virus type I interacts directly with serum response factor (SRF) and that Tax1 activates the transcription of several cellular immediate-early genes through the SRF binding site (CArG box). This activation required the transcriptional activation function of Tax
Effect of CD4 gene expression on adenovirus replication.: J Virol. 1994 Nov;68(11):7284-91. Unique Identifier : AIDSLINE MED/95018640; Hotta J; Shi L; Ginsberg HS; Department of Microbiology, College of Physicians and Surgeons,; Columbia University, New York, New York 10032.; The gene encoding the CD4 receptor was introduced into KB cells to establish the KBT4 cell line, a cell line susceptible to infection with human immunodeficiency virus type 1. Adenovirus replication was found to be significantly less in these cells than in the parental KB cells. Similar decreased adenovirus type 5 (Ad
Genetic diversity of human immunodeficiency virus type 2: evidence for distinct sequence subtypes with differences in virus biology.: J Virol. 1994 Nov;68(11):7433-47. Unique Identifier : AIDSLINE GENBANK/L33097; Gao F; Yue L; Robertson DL; Hill SC; Hui H; Biggar RJ; Neequaye AE; Whelan TM; Ho DD; Shaw GM; et al; Department of Medicine, University of Alabama at Birmingham; 35294.; The virulence properties of human immunodeficiency virus type 2 (HIV-2) are known to vary significantly and to range from relative attenuation in certain individuals to high-level pathogenicity in others. These differences in clinical manifestations may, at least in part, be determined by genetic differences among inf
Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences.: J Virol. 1994 Nov;68(11):7467-81. Unique Identifier : AIDSLINE +; Korber BT; Kunstman KJ; Patterson BK; Furtado M; McEvilly MM; Levy R; Wolinsky SM; Theory Division, Los Alamos National Laboratory, New Mexico; 87545.; Human immunodeficiency virus type 1 (HIV-1) sequences were generated from blood and from brain tissue obtained by stereotactic biopsy from six patients undergoing a diagnostic neurosurgical procedure. Proviral DNA was directly amplified by nested PCR, and 8 to 36 clones from each sample were sequenced. Phylogenetic an
A point mutation in the env gene of a murine leukemia virus induces syncytium formation and neurologic disease.: J Virol. 1994 Nov;68(11):7516-24. Unique Identifier : AIDSLINE MED/95018665; Park BH; Matuschke B; Lavi E; Gaulton GN; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104.; TR1.3 is a Friend-related murine leukemia virus that has been shown to cause intracerebral hemorrhages and neurologic disease due to infection and subsequent cytopathology of cerebral vessel endothelium. A striking feature of this pathology is the formation of endothelial cell syncytia. The pathogenesis of this diseas
Apoptosis induced in mouse hepatitis virus-infected cells by a virus-specific CD8+ cytotoxic T-lymphocyte clone.: J Virol. 1994 Nov;68(11):7540-5. Unique Identifier : AIDSLINE MED/95018669; Shibata S; Kyuwa S; Lee SK; Toyoda Y; Goto N; Laboratory of Veterinary Pathology, Faculty of Agriculture,; University of Tokyo, Japan.; Morphological changes of mouse hepatitis virus-infected J774.1 cells cocultured with cloned mouse hepatitis virus-specific CD8+ cytotoxic T lymphocytes were examined by electron microscopy. Condensation and margination of chromatin, cellular shrinkage with severe vacuolar degeneration, and blebbing were observed. In a
Alpha interferon-induced antiretroviral activities: restriction of viral nucleic acid synthesis and progeny virion production in human immunodeficiency virus type 1-infected monocytes.: J Virol. 1994 Nov;68(11):7559-65. Unique Identifier : AIDSLINE MED/95018673; Baca-Regen L; Heinzinger N; Stevenson M; Gendelman HE; Department of Pathology, University of Nebraska Medical Center,; Omaha 68198-5215.; Alpha interferon (IFN-alpha) restricts multiple steps of the human immunodeficiency virus type 1 (HIV-1) life cycle. A well-described effect of IFN-alpha is in the modulation of viral nucleic acid synthesis. We demonstrate that IFN-alpha influences HIV-1 DNA synthesis principally by reducing the production of late pro
Insertion of N-linked glycosylation sites in the variable regions of the human immunodeficiency virus type 1 surface glycoprotein through AAT triplet reiteration.: J Virol. 1994 Nov;68(11):7566-9. Unique Identifier : AIDSLINE MED/95018674; Bosch ML; Andeweg AC; Schipper R; Kenter M; Laboratory of Immunobiology, National Institute for Public Health; and Environmental Protection, The Netherlands.; Variable regions with sequence length variation in the human immunodeficiency virus type 1 envelope exhibit an unusual pattern of codon usage with AAT, ACT, and AGT together composing > 70% of all codons used. We postulate that this distribution is caused by insertion of AAT triplets followed by point mutations and se
Intravirion reverse transcripts in the peripheral blood plasma on human immunodeficiency virus type 1-infected individuals.: J Virol. 1994 Nov;68(11):7591-7. Unique Identifier : AIDSLINE MED/95018679; Zhang H; Bagasra O; Niikura M; Poiesz BJ; Pomerantz RJ; Dorrance H. Hamilton Laboratories, Department of Medicine,; Jefferson Medical College, Thomas Jefferson University,; Philadelphia, Pennsylvania 19107.; Variable levels of viral DNA have been demonstrated within human immunodeficiency virus type 1 (HIV-1) virions purified from cell cultures. In the present studies, it is demonstrated that DNase-resistant viral DNA is associated with HIV-1 virions purified from the peripheral blood plasma of both symptomatic and asympt
Amino acid sequence analysis of the proteolytic cleavage products of the bovine immunodeficiency virus Gag precursor polypeptide.: J Virol. 1994 Nov;68(11):7620-7. Unique Identifier : AIDSLINE MED/95018684; Tobin GJ; Sowder RC 2nd; Fabris D; Hu MY; Battles JK; Fenselau C; Henderson LE; Gonda MA; Laboratory of Cell and Molecular Structure, Program Resources,; Inc./DynCorp, National Cancer Institute-Frederick Cancer Research; and Development Center, Maryland 21702-1201.; Bovine immunodeficiency virus Gag proteins were purified from virions, and their amino acid sequences and molecular masses were determined. The matrix, capsid, and nucleocapsid (MA, CA, and NC, respectively) and three smaller proteins (p2L, p3, and p2) were found to have molecular masses of 14.6, 24.6, and 7.3 and 2.5
Selective amplification of simian immunodeficiency virus genotypes after intrarectal inoculation of rhesus monkeys.: J Virol. 1994 Nov;68(11):7649-53. Unique Identifier : AIDSLINE MED/95018689; Trivedi P; Meyer KK; Streblow DN; Preuninger BL; Schultz KT; Pauza CD; Department of Pathology and Laboratory Medicine, University of; Wisconsin, Madison 53706-1532.; Animal models for sexual transmission of human immunodeficiency virus can define the influences of virus type, dose, and route of inoculation on infection and clinical outcome. We used an uncloned simian immunodeficiency virus stock (SIVmac) to inoculate cells in vitro and to inoculate rhesus monkeys by intravenous an
Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus.: J Virol. 1994 Nov;68(11):7665-7. Unique Identifier : AIDSLINE MED/95018692; LaBranche CC; Sauter MM; Haggarty BS; Vance PJ; Romano J; Hart TK; Bugelski PJ; Hoxie JA; Hematology-Oncology Division, Hospital of the University of; Pennsylvania, Philadelphia 19104.
Fournier's gangrene as the presenting sign of an undiagnosed human immunodeficiency virus infection [see comments]: J Urol. 1994 Nov;152(5 Pt 1):1552-4. Unique Identifier : AIDSLINE MED/95018741; McKay TC; Waters WB; Department of Urology, Loyola University Medical Center, Maywood,; Illinois.
International disunity on HIV vaccine efficacy trials [news]: JAMA. 1994 Oct 12;272(14):1090-1. Unique Identifier : AIDSLINE MED/95018877; Cotton P
From the Centers for Disease Control and Prevention. AIDS among racial/ethnic minorities--US, 1993.: JAMA. 1994 Oct 19;272(15):1163-4. Unique Identifier : AIDSLINE MED/95018910
Safety and cost-effectiveness of solvent-detergent-treated plasma. In search of a zero-risk blood supply.: JAMA. 1994 Oct 19;272(15):1210-4. Unique Identifier : AIDSLINE MED/95018929; AuBuchon JP; Birkmeyer JD; Department of Pathology, Dartmouth-Hitchcock Medical Center,; Lebanon, NH 03756.; OBJECTIVE--To determine the public health and economic implications of solvent-detergent-treated frozen plasma (SD FP). While this processing technique nearly eliminates the risk of transmitting lipid-enveloped viruses (hepatitis B and C and human immunodeficiency virus), it has associated costs and, because it requir
High-tech assault on HIV: gene therapy [news]: JAMA. 1994 Oct 26;272(16):1235-6. Unique Identifier : AIDSLINE MED/95018935; Cotton P
From the Health Resources and Services Administration [news]: JAMA. 1994 Oct 26;272(16):1242. Unique Identifier : AIDSLINE MED/95018938; Sumaya CV; Macher AM; Bowen GS; Goosby EP
[A patient with adult T cell leukemia in smoldering stage expressing an aberrant phenotype of CD3- and CD4+]: Rinsho Ketsueki. 1994 Aug;35(8):774-9. Unique Identifier : AIDSLINE MED/95019154; Nasu K; Matsubayashi H; Maeda Y; Matsuura R; Suzuki A; Kasakura S; Department of Clinical Pathology, Kobe City General Hospital.; This report is of a patient with adult T cell leukemia (ATL) in the smoldering stage showing expression an aberrant phenotype of CD3-, CD4+ and CD8-. A 71-year-old woman was admitted to our hospital in December 1992, because of skin eruption and persistent low grade fever. Laboratory examination showed a leukocyte cou
[Measurement of ADF/thioredoxin in human serum and its clinical significance]: Rinsho Byori. 1994 Aug;42(8):853-9. Unique Identifier : AIDSLINE MED/95019213; Kitaoka Y; Sachi Y; Mori T; Yodoi J; Department of Biological Responses, Kyoto University.; The adult T cell leukemia (ATL)-derived factor (ADF) was first described as an interleukin 2 receptor alpha chain (IL-2R alpha) inducing factor which is produced by an HTLV-I infected cell line. Subsequent purification and gene cloning proved that it is a human homologue of a bacterial reducing coenzyme, thioredoxin (
HTLV-I associated uveitis and hyperthyroidism.: Jpn J Ophthalmol. 1994;38(1):56-61. Unique Identifier : AIDSLINE MED/95019292; Nakao K; Ohba N; Otsuka S; Okubo A; Yanagita T; Hashimoto N; Arimura H; Department of Ophthalmology, Kagoshima University Faculty of; Medicine, Japan.; The records of 76 consecutive patients with etiology-undefined uveitis examined during the 3-year period between 1990 and 1992 were reviewed and 6 patients were found who had concomitant hyperthyroidism. These 6 patients had presented with uveitis symptoms and signs when hyperthyroidism was relieved with thiamazole th
Elevated anti-human T-cell lymphotropic virus type I antibody in serum of patients with retinal vasculitis and uveitis living in Izumo area.: Jpn J Ophthalmol. 1994;38(1):62-6. Unique Identifier : AIDSLINE MED/95019293; Kawamoto K; Hayasaka S; Department of Ophthalmology, Shimane Medical University, Japan.; Four patients with human T-lymphotropic virus type I associated myelopathy (HAM) were examined ophthalmologically, and serum titers to human T-lymphotropic virus type I (HTLV-I) in 11 patients with nonspecific retinal vasculitis or uveitis were determined. All of the patients lived in the Izumo area. All 4 patients wi
Host virus interactions and the molecular regulation of HIV-1: role in the pathogenesis of HIV-associated nephropathy [editorial]: Kidney Int. 1994 Jul;46(1):16-27. Unique Identifier : AIDSLINE MED/95019431; Rappaport J; Kopp JB; Klotman PE
[Clinical studies of reduced accommodation in patients with HIV-1 infection]: Klin Monatsbl Augenheilkd. 1994 Jun;204(6):523-6. Unique Identifier : AIDSLINE MED/95019504; Thierfelder S; Mellinghoff-Kreplin G; Hasenfratz G; Universitats-Augenklinik Wurzburg.; PROBLEM Reduced accommodation in HIV-patients has been described. Yet, in literature, statistics on this item cannot be found. PATIENTS AND METHOD In 58 HIV-infected subjects of different infection stages, accommodation was measured using Clement-Clark s accommodometer. Average age was 34.9 years (sigma = 8.3 years) S
Establishing specific retrovirus-free breeding colonies of macaques: an approach to primary screening and surveillance.: Lab Anim Sci. 1994 Jun;44(3):217-21. Unique Identifier : AIDSLINE MED/95019573; Lerche NW; Yee JL; Jennings MB; Simian Retrovirus Reference Laboratory, University of California,; Davis 95616.; For reasons of occupational safety and animal health, as well as to improve the quality of nonhuman primates used in biomedical research, the establishment and maintenance of specific retrovirus-free breeding colonies of macaques (genus Macaca) are now high priorities. Sensitive and specific screening tests are now av
Evidence for bovine leukemia virus in mammary epithelial cells of infected cows.: Lab Invest. 1994 Sep;71(3):359-65. Unique Identifier : AIDSLINE MED/95019593; Buehring GC; Kramme PM; Schultz RD; School of Public Health, University of California, Berkeley.; BACKGROUND: Bovine leukemia virus (BLV), a retrovirus, usually causes a subclinical infection of dairy and beef cattle, but in
Have you met your HIV/AIDS CE requirement yet?: Ky Nurse. 1994 Jul-Sep;42(3):21. Unique Identifier : AIDSLINE MED/95019723
Elevated plasma soluble interleukin 2 receptor level correlates with defective natural killer and CD8+ T-cells in myelodysplastic syndromes.: Leuk Res. 1994 Oct;18(10):777-82. Unique Identifier : AIDSLINE MED/95019779; Yokose N; Ogata K; Ito T; An E; Tamura H; Dan K; Hamaguchi H; Sakamaki H; Onozawa Y; Nomura T; Third Department of Internal Medicine, Nippon Medical School,; Tokyo, Japan.; The plasma soluble interleukin 2 receptor (sIL-2R) level and its relationships with haematologic and immunologic data were examined in 40 patients with myelodysplastic syndromes (MDS). The plasma sIL-2R level was significantly higher in the high-risk MDS group (refractory anaemia with excess blasts (RAEB), RAEB in tra
Increased serum levels of C-terminal parathyroid hormone-related protein in different diseases associated with HTLV-1 infection.: Leukemia. 1994 Oct;8(10):1708-11. Unique Identifier : AIDSLINE MED/95019813; Yamaguchi K; Kiyokawa T; Watanabe T; Ideta T; Asayama K; Mochizuki M; Blank A; Takatsuki K; Blood Transfusion Service, Kumamoto University School of; Medicine, Japan.; We analyzed the serum levels of C-terminal parathyroid hormone-related protein (C-PTHrP) in asymptomatic carriers of human T lymphotropic virus type 1 (HTLV-1) and patients with three HTLV-1 related diseases; adult T-cell leukemia (ATL), HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 uv
HTLV-I positive adult T-cell leukaemia/lymphoma (ATLL) in Chile.: Leukemia. 1994 Oct;8(10):1763-7. Unique Identifier : AIDSLINE MED/95019821; Cabrera ME; Labra S; Catovsky D; Ford AM; Colman SM; Greaves MF; Matutes E; Department of Medicine, Faculty of Medicine, University of Chile,; Hospital del Salvador, Santiago de Chile.; We describe the clinical and laboratory features of nine patients born in Chile with HTLV-I-positive adult T-cell leukemia/lymphoma (ATLL). All were adults (median age 51 years) of Caucasian origin without evidence of Indian or foreign extraction and none had been out of the country
[From make love and not war to the practice of safe sex: personal history of AIDS and various reflexions]: Med Clin (Barc). 1994 Jul 2;103(5):181-5. Unique Identifier : AIDSLINE MED/95019943; Olle Goig JE
[Efficacy of intracavitary amphotericin B in the treatment of aspergilloma associated with the acquired immunodeficiency syndrome (letter)]: Med Clin (Barc). 1994 Sep 10;103(7):279. Unique Identifier : AIDSLINE MED/95019961; Pintado V; Montilla P; Casado JL; Guerrero A
Gnashings of HIV.: Lancet. 1994 Oct 1;344(8927):904. Unique Identifier : AIDSLINE MED/95020006; Scully C; Mortimer P; Eastman Dental Institute for Oral Healthcare Sciences, London,; UK.
HIV transfection in brothels [letter]: Lancet. 1994 Oct 1;344(8927):953. Unique Identifier : AIDSLINE MED/95020030; Shields JW
HIV-1 subtype E in Yunnan, China [letter]: Lancet. 1994 Oct 1;344(8927):953-4. Unique Identifier : AIDSLINE MED/95020031; Cheng H; Zhang J; Capizzi J; Young NL; Mastro TD
Localisation of HIV-1 to human papillomavirus associated cervical lesions [letter]: Lancet. 1994 Oct 1;344(8927):954-5. Unique Identifier : AIDSLINE MED/95020032; Vernon SD; Zaki SR; Reeves WC
Needle-exchange programme against AIDS in Brazil [news]: Lancet. 1994 Oct 8;344(8928):1013. Unique Identifier : AIDSLINE MED/95020060; Csillag C
Amplification of Mycobacterium tuberculosis from peripheral blood [letter; comment]: Lancet. 1994 Oct 8;344(8928):1021. Unique Identifier : AIDSLINE MED/95020073; Palenque E; Rebollo MJ; Aguado JM
Nosocomial HIV-1 transmission and primary prevention in Romania [letter; comment]: Lancet. 1994 Oct 8;344(8928):1028-9. Unique Identifier : AIDSLINE MED/95020089; Apetrei C; Buzdugan I; Mitroi I; Iancu L; Duca M
Nosocomial HIV-1 transmission and primary prevention in Romania [letter; comment]: Lancet. 1994 Oct 8;344(8928):1029. Unique Identifier : AIDSLINE MED/95020090; Kuvin SF
Red light on Calcutta; health via schools in Andhra Pradesh.: Lancet. 1994 Oct 15;344(8929):1038. Unique Identifier : AIDSLINE MED/95020118; Fox R
HIV and the immune system [news]: Lancet. 1994 Oct 15;344(8929):1081. Unique Identifier : AIDSLINE MED/95020137; Rowe PM
New international AIDS organisation [letter; comment]: Lancet. 1994 Oct 15;344(8929):1092. Unique Identifier : AIDSLINE MED/95020157; Arya SC
On being poor with HIV [comment]: Lancet. 1994 Oct 22;344(8930):1100-1. Unique Identifier : AIDSLINE MED/95020171; Sampson JH; Neaton J; Research and Education Group/Oregon SW Washington Community; Programs for Clinical Research on AIDS, Portland.
Prevalence of serum and salivary antibodies to HTLV-1 in Sjogren's syndrome [see comments]: Lancet. 1994 Oct 22;344(8930):1116-9. Unique Identifier : AIDSLINE MED/95020177; Terada K; Katamine S; Eguchi K; Moriuchi R; Kita M; Shimada H; Yamashita I; Iwata K; Tsuji Y; Nagataki S; et al; Department of Bacteriology, Nagasaki University School of; Medicine, Japan.; There is accumulating evidence that human T-lymphotropic virus-1 (HTLV-1) infection contributes to the development of various inflammatory disorders. To elucidate the relation between the infection and Sjogren s syndrome, seroepidemiological and virological studies were conducted on patients with this syndrome in Naga
Lower socioeconomic status and shorter survival following HIV infection [see comments]: Lancet. 1994 Oct 22;344(8930):1120-4. Unique Identifier : AIDSLINE MED/95020178; Hogg RS; Strathdee SA; Craib KJ; O'Shaughnessy MV; Montaner JS; Schechter MT; British Columbia Centre for Excellence in HIV/AIDS, University of; British Columbia, Vancouver, Canada.; We studied the association between socioeconomic status and survival in a prospective study of 364 HIV-infected homosexual men who were recruited during 1982-84. The participants were divided by annual income; those earning above Canadian $10,000 (high-income; n = 274) and those below $10,000 (low-income; n = 90) at r
Go-ahead for HIV vaccine trial in developing world [news]: Lancet. 1994 Oct 29;344(8931):1218. Unique Identifier : AIDSLINE MED/95020241; Thompson C
[Ten facts about AIDS in Africa. A presentation by K.M. De Cock of Project Retroci]: Med Trop (Mars). 1994;54(2):107-9. Unique Identifier : AIDSLINE MED/95020474; Rey JL; Service de Sante des Armees ORSTOM, Montpellier, France.
[Trends in the HIV/AIDS epidemic in Benin (1990-1993]: Med Trop (Mars). 1994;54(2):137-40. Unique Identifier : AIDSLINE MED/95020482; Davo N; Adjovi C; Anagonou S; Foundohou J; Helynck B; Josse R; Programme National de Lutte contre le SIDA - Benin, Cotonou.; Since 1990 within the framework of a National Program against AIDS, surveillance in the Republic of Benin has relied on disease-control centers established in 20 selected locations. Seropositivity for HIV is always established by Western-blotting and diagnosis of AIDS is based on BA
Cytomegalovirus vasculitis. Case reports and review of the literature.: Medicine (Baltimore). 1994 Sep;73(5):246-55. Unique Identifier : AIDSLINE MED/95020518; Golden MP; Hammer SM; Wanke CA; Albrecht MA; Division of Infectious Diseases, New England Deaconess Hospital,; Boston, Massachusetts.; Cytomegalovirus ( CMV ) infection is a substantial cause of morbidity and mortality among immunocompromised patients. It may present with a mild, self-limited syndrome, retinitis, colitis, or invasive disease with pneumonitis, hepatitis, and bone marrow suppressio
Systemic strongyloidiasis in patients infected with the human immunodeficiency virus. A report of 3 cases and review of the literature.: Medicine (Baltimore). 1994 Sep;73(5):256-63. Unique Identifier : AIDSLINE MED/95020519; Celedon JC; Mathur-Wagh U; Fox J; Garcia R; Wiest PM; Pulmonary and Critical Care Division, Brown University School of; Medicine, Providence, Rhode Island.; We report 3 cases of systemic strongyloidiasis in HIV-infected individuals and review 11 additional cases reported in the English-language literature. Systemic strongloidiasis is a rare and potentially fatal complication of late-stage HIV disease. A combination of gastrointestinal and respiratory symptoms in an HIV-in
Construction and use of integrative vectors to express foreign genes in mycobacteria.: Mol Microbiol. 1993 Dec;10(5):983-93. Unique Identifier : AIDSLINE MED/95020585; Dellagostin OA; Wall S; Norman E; O'Shaughnessy T; Dale JW; McFadden J; Molecular Microbiology Group, School of Biological Sciences,; University of Surrey, Guildford, UK.; We have constructed a mycobacterial integrative vector by placing two copies of the insertion sequence IS900 flanking a kanamycin-resistance gene into a suicide vector unable to replicate in mycobacteria. The Mycobacterium leprae gene encoding the M. leprae 18 kDa protein was cloned between the two copies of IS900 t
1994 update on health risk behaviors.: Mich Med. 1994 Aug;93(8):12-3. Unique Identifier : AIDSLINE MED/95020772; Lester J
Polio vaccines and the origin of AIDS [see comments]: Med Hypotheses. 1994 Jun;42(6):347-54. Unique Identifier : AIDSLINE MED/95020815; Elswood BF; Stricker RB; University of California San Francisco, Mission Center; 94143-0286.; Although mass vaccination programs have resulted in the eradication of a number of human infectious diseases, vaccine contamination has been a persistent concern. In particular, it is now known that the early polio vaccines were contaminated with at least one monkey virus, SV40. The transfer of monkey viruses to man v
The first Australian case of human T-cell lymphotropic virus type II infection [letter]: Med J Aust. 1994 Oct 3;161(7):451. Unique Identifier : AIDSLINE MED/95020841; Bolton WV; Best SJ; Davis AR; Kenrick KG; Wylie BR
Endobronchial nocardiosis in a patient with AIDS.: Med J Aust. 1994 Oct 17;161(8):498-9. Unique Identifier : AIDSLINE MED/95020866; Pickles RW; Malcolm JA; Sutherland DC; John Hunter Hospital, New Lambton Heights, NSW.
Evidence of HIV transmission in an Australian prison [letter; comment]: Med J Aust. 1994 Oct 17;161(8):508-9. Unique Identifier : AIDSLINE MED/95020871; Liew CY
[Progress in clinical oncology: ECCO-7]: Med Klin. 1994 Jul 15;89(7):397-9. Unique Identifier : AIDSLINE MED/95020973; Steinmetz HT; Medizinische Klinik I, Universitat zu Koln.
FDA considers home AIDS tests [news]: Minn Med. 1994 Aug;77(8):55. Unique Identifier : AIDSLINE MED/95021018
[HIV infection. The risks for health providers and prevention and control measures]: Minerva Stomatol. 1994 Jun;43(6):279-87. Unique Identifier : AIDSLINE MED/95021025; Barberis M; Brenna Betti N; Lauritano D; Salvato A; Spadari F; Villa S; Istituto Scientifico Ospedale S. Raffaele, Polo Odontoiatrico,; Universita degli Studi di Milano.; The odontostomathologist and the dentist expose themselves to pathogenic agents present in the oral cavity. Taking in consideration at the present time the increasing number of seropositive patients, HIV infection and its pathogenic manifestations are of great interest. Considering that the main transmission of the vi
Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-kappa B.: Mol Cell Biol. 1994 Oct;14(10):6443-51. Unique Identifier : AIDSLINE MED/95021172; Kanno T; Brown K; Franzoso G; Siebenlist U; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.; The human T-cell leukemia virus type I (HTLV-I) Tax protein induces the expression of cellular genes, at least in part, by activating the endogenous NF-kappa B transcription factors. Induced expression of cellular genes is thought to be important for transformation of T cells to continued growth, a prelude to the esta
An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation.: Mol Cell Biol. 1994 Oct;14(10):6570-83. Unique Identifier : AIDSLINE MED/95021185; Perkins ND; Agranoff AB; Pascal E; Nabel GJ; Howard Hughes Medical Institute, University of Michigan Medical; Center, Ann Arbor 48109-0650.; Induction of human immunodeficiency virus type 1 (HIV-1) gene expression in stimulated T cells has been attributed to the activation of the transcription factor NF-kappa B. The twice-repeated kappa B sites within the HIV-1 long terminal repeat are in close proximity to three binding sites for Sp1. We have previously s
Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene.: Mol Cell Biol. 1994 Nov;14(11):7377-84. Unique Identifier : AIDSLINE MED/95021266; Sun SC; Elwood J; Beraud C; Greene WC; Gladstone Institute of Virology and Immunology, University of; California, San Francisco 94141-9100.; The tax gene product of human T-cell leukemia virus type I (HTLV-I) is a potent transcriptional activator that both stimulates viral gene expression and activates an array of cellular genes involved in T-cell growth. Tax acts indirectly by inducing or modifying the action of various host transcription factors, includi
The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments.: Mol Cell Biol. 1994 Nov;14(11):7436-44. Unique Identifier : AIDSLINE MED/95021273; Kalland KH; Szilvay AM; Brokstad KA; Saetrevik W; Haukenes G; Department of Microbiology and Immunology, Gade Institute, Bergen; High Technology Centre, University of Bergen, Norway.; A retroviral regulatory protein, Rev (regulator of virion protein expression), is made in cells infected by human immunodeficiency virus (HIV). Rev is essential for the completion of the retroviral life cycle and interacts with the host cell at some posttranscriptional step in order to express the incompletely spliced
Structural characterization of broadly neutralizing human monoclonal antibodies against the CD4 binding site of HIV-1 gp120.: Mol Immunol. 1994 Oct;31(15):1149-60. Unique Identifier : AIDSLINE GENBANK/M88500; Bagley J; Dillon PJ; Rosen C; Robinson J; Sodroski J; Marasco WA; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Harvard Medical School, Boston, MA 02115.; The human monoclonal antibodies (mAbs) 15e and 21h are derived from HIV-1-infected individuals. They block CD4 binding, recognize conformation-dependent discontinuous epitopes on gp120 and neutralize a broad range of laboratory strains and primary isolates of HIV-1. To determine if a structural basis for neutralizatio
Lipophilic multiple antigen peptide system for peptide immunogen and synthetic vaccine.: Mol Immunol. 1994 Oct;31(15):1191-9. Unique Identifier : AIDSLINE MED/95021329; Huang W; Nardelli B; Tam JP; Department of Microbiology and Immunology, Vanderbilt University,; Nashville, TN 37232-2363.; We describe the development and structural requirements of a new lipophilic multiple antigen peptide (lipoMAP) system for immunogens that contains a built-in lipophilic adjuvant and has the ability to elicit cytotoxic T-lymphocytes (CTLs). In addition to the peptide antigens of choice at the amino terminus, the basic
In vitro susceptibility of Candida albicans, Austria 1992.: Mycoses. 1993 Nov-Dec;36(11-12):411-6. Unique Identifier : AIDSLINE MED/95021472; Allerberger F; Fassl A; Niederwieser D; Zangerle R; Lingnau W; Dierich MP; Institute of Hygiene, University of Innsbruck, Austria.; A total of 38 isolates of Candida albicans were collected from clinical specimens and tested for minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) of amphotericin B, flucytosine and fluconazole. For amphotericin B and flucytosine all patients had isolates with MICs
Cutaneous cryptococcosis in AIDS: successful treatment with itraconazole.: Mycoses. 1993 Nov-Dec;36(11-12):433-5. Unique Identifier : AIDSLINE MED/95021477; Bettoli V; Virgili A; Zampino MR; Bedetti A; Montanari P; Istituto di Clinica Dermatologica, Universita di Ferrara, Italy.; A case of cutaneous cryptococcosis in a HIV-positive 46-year-old farmer is presented. The situation could be cured by applying itraconazole 400 mg day-1 for 45 days.
Zygomycosis of the spleen in a patient with the acquired immunodeficiency syndrome.: Mycoses. 1993 Nov-Dec;36(11-12):437-9. Unique Identifier : AIDSLINE MED/95021478; Teira R; Trinidad JM; Eizaguirre B; Ortiz J; Santamaria JM; Seccion de Enfermedades Infecciosas, Hospital Civil de Bilbao,; Spain.
Fluconazole-resistant oral candidosis in a repeatedly treated female AIDS patient.: Mycoses. 1994 Jan-Feb;37(1-2):35-8. Unique Identifier : AIDSLINE MED/95021489; Thomas-Greber E; Korting HC; Bogner J; Goebel FD; Department of Dermatology, Ludwigs-Maximilians-Univeristy,; Munich, Germany.; A 29-year-old female suffering from full-blown AIDS received fluconazole 400 mg day-1 for a long period for treatment of oral candidosis, pseudomembranous type. She had previously received this drug repeatedly for the same reason, yet manifest disease persisted. She was therefore put on parenteral amphotericin B, whic
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group [see comments]: N Engl J Med. 1994 Nov 3;331(18):1173-80. Unique Identifier : AIDSLINE MED/95021559; Connor EM; Sperling RS; Gelber R; Kiselev P; Scott G; O'Sullivan MJ; VanDyke R; Bey M; Shearer W; Jacobson RL; et al; Department of Pediatrics, University of Medicine and Dentistry of; New Jersey, New Jersey Medical School, Newark.; BACKGROUND AND METHODS. Maternal-infant transmission is the primary means by which young children become infected with human immunodeficiency virus type 1 (HIV). We conducted a randomized, double-blind, placebo-controlled trial of the efficacy and safety of zidovudine in reducing the risk of maternal-infant HIV transm
A controlled trial of intravenous immune globulin for the prevention of serious bacterial infections in children receiving zidovudine for advanced human immunodeficiency virus infection. Pediatric AIDS Clinical Trials Group [see comments]: N Engl J Med. 1994 Nov 3;331(18):1181-7. Unique Identifier : AIDSLINE MED/95021560; Spector SA; Gelber RD; McGrath N; Wara D; Barzilai A; Abrams E; Bryson YJ; Dankner WM; Livingston RA; Connor EM; University of California, San Diego, La Jolla 92093-0672.; BACKGROUND. Serious bacterial infections are common in children infected with the human immunodeficiency virus (HIV). Studies performed before zidovudine became standard therapy found that intravenous immune globulin decreases the number of serious bacterial infections in these children. We designed a multicenter stud
Reducing the risk of maternal-infant transmission of HIV: a door is opened [editorial; comment]: N Engl J Med. 1994 Nov 3;331(18):1222-3. Unique Identifier : AIDSLINE MED/95021568; Rogers MF; Jaffe HW
Ethical challenges posed by zidovudine treatment to reduce vertical transmission of HIV [editorial; comment] [published erratum appears in N Engl J Med 1994 Dec 15;331(24):1667] [see comments]: N Engl J Med. 1994 Nov 3;331(18):1223-5. Unique Identifier : AIDSLINE MED/95021569; Bayer R
Postmortem viability of human immunodeficiency virus--implications for the teaching of anatomy [letter]: N Engl J Med. 1994 Nov 10;331(19):1315. Unique Identifier : AIDSLINE MED/95021612; de Craemer D
First reported Nocardia otitidiscaviarum infection in an AIDS patient in Italy.: Mycopathologia. 1994 Jun;126(3):131-6. Unique Identifier : AIDSLINE MED/95021642; Castelli L; Zlotnik H; Ponti R; Vidotto V; Laboratorio Analisi Chimico-Cliniche e Microbiologiche, Ospedale; Amedeo di Savoia, Torino, Italy.; Nocardiosis is a well-described infection in immunocompromised patients, and has been rarely documented in patients with AIDS. Nocardia asteroides is the most frequently isolated etiologic agent. Rare cases are due to N. brasiliensis and N. otitidiscaviarum. This work describes the first case of nocardiosis in
Combating AIDS [letter]: Nature. 1994 Oct 6;371(6497):470. Unique Identifier : AIDSLINE MED/95021671; Whitehead NE
Are there tragedies without villains? [editorial]: Nature. 1994 Oct 13;371(6498):543. Unique Identifier : AIDSLINE MED/95021688
Blood scandal raises spectre of Dreyfus case [news]: Nature. 1994 Oct 13;371(6498):548. Unique Identifier : AIDSLINE MED/95021693; Butler D
Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma.: Nature. 1994 Oct 20;371(6499):674-80. Unique Identifier : AIDSLINE MED/95021735; Ensoli B; Gendelman R; Markham P; Fiorelli V; Colombini S; Raffeld M; Cafaro A; Chang HK; Brady JN; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.; Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi s sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix p
Lung mass and altered immunity. Not always what it seems.: N C Med J. 1994 Jul;55(7):310-1. Unique Identifier : AIDSLINE MED/95021799; Zollinger RW 2nd; Taylor FH; Shenoy VB; Edgerton TA; Harr CD; Charlotte Cardiothoracic Surgical Associates 28211.
Gender bias in HIV screening? [letter; comment]: N C Med J. 1994 Aug;55(8):322-3. Unique Identifier : AIDSLINE MED/95021801; Katz SL
[Analysis of the AIDS epidemic in The Netherlands, 1982-1993 (published errata appear in Ned Tijdschr Geneeskd 1994 Nov 5;138(45):2272 and 1994 Dec 31;138(53):2688)]: Ned Tijdschr Geneeskd. 1994 Sep 24;138(39):1954-9. Unique Identifier : AIDSLINE MED/95021877; Houweling H; Heisterkamp SH; van Wijngaarden JK; Wiessing LG; Coutinho RA; Jager JC; Centrum voor Infectieziekten Epidemiologie, Rijkinstituut voor; Volksgezondheid en Milieuhygiene, Bilthoven.; OBJECTIVE. Description of the epidemiology and transmission categories of AIDS in the Netherlands . DESIGN. Descriptive. SETTING. The Netherlands. METHOD. Analysis of all registered AIDS patients until 31 December 1993. Trends in the composition of this population were studied
Skeletal muscle involvement in HIV-infected patients.: Neuropathol Appl Neurobiol. 1994 Jun;20(3):232-7. Unique Identifier : AIDSLINE MED/95022017; Gherardi RK; Department of Pathology (Neuropathology), Hopital Henri Mondor,; Creteil, France.; Skeletal muscle involvement may occur at all stages of human immunodeficiency virus (HIV)-infection, and represents the first manifestation of the disease in some patients. There have been many controversies about the classification of myopathies related to HIV infection. We usually classify muscle involvement in HIV-
Primary central nervous system malignant non-Hodgkin's lymphomas from HIV-infected and non-infected patients: expression of cellular surface proteins and Epstein-Barr viral markers.: Neuropathol Appl Neurobiol. 1994 Jun;20(3):243-52. Unique Identifier : AIDSLINE MED/95022019; Auperin I; Mikolt J; Oksenhendler E; Thiebaut JB; Brunet M; Dupont B; Morinet F; Department of Bacteriology and Virology, Saint-Louis Hospital,; Paris VII University, France.; The increased incidence of primary central nervous system malignant non-Hodgkin s lymphomas (PCNSL) in HIV- and non-HIV-infected patients and the demonstration of Epstein-Barr virus (EBV) in these tumours may indicate relationships between PCNSL and EBV. Consequently expression of EBV-induced antigens and cellular mar
Oligodendrocyte reactions and cell proliferation markers in human demyelinating diseases.: Neuropathol Appl Neurobiol. 1994 Jun;20(3):272-81. Unique Identifier : AIDSLINE MED/95022022; Morris CS; Esiri MM; Sprinkle TJ; Gregson N; Department of Neuropathology, Radcliffe Infirmary, Oxford, UK.; We have carried out immunocytochemical reactions using antibodies to markers of oligodendrocytes, astrocytes, microglia and proliferating cells (PCNA) in sections of human brain in a variety of demyelinating conditions and human immunodeficiency virus (HIV) infection. In the acute phases of demyelinating diseases we f
Varicella-zoster virus myelitis: an expanding spectrum.: Neurology. 1994 Oct;44(10):1818-23. Unique Identifier : AIDSLINE MED/95022192; Gilden DH; Beinlich BR; Rubinstien EM; Stommel E; Swenson R; Rubinstein D; Mahalingam R; Department of Neurology, University of Colorado School of; Medicine, Denver.; We report four cases of varicella-zoster virus (VZV)-associated myelopathy in adults. Myelopathy was remitting-exacerbating in two remarkable instances, once acute and once chronic. VZV myelopathy was diagnosed based on the close temporal relationship between rash and onset of myelopathy, and for the first time, by po
Temporal trends in the incidence of HIV-1-related neurologic diseases: Multicenter AIDS Cohort Study, 1985-1992.: Neurology. 1994 Oct;44(10):1892-900. Unique Identifier : AIDSLINE MED/95022206; Bacellar H; Munoz A; Miller EN; Cohen BA; Besley D; Selnes OA; Becker JT; McArthur JC; Johns Hopkins University, Baltimore, MD.; OBJECTIVE: To describe temporal trends in the incidence of human immunodeficiency virus (HIV)-related neurologic diseases in the Multicenter AIDS Cohort Study from 1985 to 1992. METHODS: The incidence rates of six neurologic disorders were examined: toxoplasmosis, cryptococcal meningitis, primary
Acute rhabdomyolysis in patients infected by human immunodeficiency virus.: Neurology. 1994 Sep;44(9):1692-6. Unique Identifier : AIDSLINE MED/95022262; Chariot P; Ruet E; Authier FJ; Levy Y; Gherardi R; Department of Pathology, Hopital Henri Mondor, Creteil, France.; To delineate the spectrum of rhabdomyolysis associated with human immunodeficiency virus (HIV) infection, we reviewed the clinical and pathologic data from nine HIV-infected individuals with acute rhabdomyolysis, and pooled data with those of 11 previously reported cases. Patients with rhabdomyolysis were at all stage
AIDS and the Red Cross.: N J Med. 1994 Aug;91(8):508. Unique Identifier : AIDSLINE MED/95022417; George JE; Weisfeld NE
AIDS [news]: N Z Med J. 1994 Sep 28;107(986 Pt 1):384. Unique Identifier : AIDSLINE MED/95022449
Confidential correction [letter; comment] [see comments]: N Y State Dent J. 1994 Aug-Sep;60(7):10-1. Unique Identifier : AIDSLINE MED/95022464; Fischman SL
Oral manifestations of HIV infection in homosexual men and intravenous drug users. Study design and relationship of epidemiologic, clinical, and immunologic parameters to oral lesions.: Oral Surg Oral Med Oral Pathol. 1994 Aug;78(2):163-74. Unique Identifier : AIDSLINE MED/95022570; Lamster IB; Begg MD; Mitchell-Lewis D; Fine JB; Grbic JT; Todak GG; el-Sadr W; Gorman JM; Zambon JJ; Phelan JA; Division of Periodontics, Columbia University, School of Dental; and Oral Surgery, New York, NY 10032.; This article describes the baseline findings from a study designed to compare the oral manifestations of HIV infection in homosexual men and intravenous drug users. Both seropositive and seronegative persons were studied. A standard examination instrument was developed to record indexes of oral disease as well as to r
Willingness of Brazilian dentists to treat an HIV-infected patient.: Oral Surg Oral Med Oral Pathol. 1994 Aug;78(2):175-7. Unique Identifier : AIDSLINE MED/95022571; Sposto MR; Goncalves F; Ferracioli A; Porter SR; Afonso W; el-Maaytah M; Di Alberti L; Scully C; University of The State of Sao Paulo, Joint Department of Oral; Medicine, Eastman Dental Institute.; A study of the willingness of 363 general dental practices in Brazil to accept a patient infected with human immunodeficiency virus for treatment of dental pain and the provision of routine dental care showed only 44% of dental practices to be willing to provide dental care. Willin
Treatment of oral candidiasis in HIV infection.: Oral Surg Oral Med Oral Pathol. 1994 Aug;78(2):211-5. Unique Identifier : AIDSLINE MED/95022577; Greenspan D; Department of Stomatology, Oral Aids Center, University of; California San Francisco.; Oral candidiasis is one of the most common clinical features of HIV infection. The lesion occurs in three predominant forms, and the two intraoral examples, pseudomembranous and erythematous, are equally predictive of the development of AIDS, independent of CD4 counts. The predominant species is C. albicans, although
Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription.: Oncogene. 1994 Nov;9(11):3099-105. Unique Identifier : AIDSLINE MED/95022618; Suzuki T; Hirai H; Yoshida M; Department of Cellular and Molecular Biology, University of; Tokyo, Japan.; Tax protein of human T cell leukemia virus type 1 (HTLV-1) enhances transcription of several cellular genes through activation of a specific enhancer, the NF-kappa B binding site. We found previously that Tax binds to NF-kappa B p50, which is a member of the Rel/NF-kappa B family proteins, and associates with the DNA
[Brief analytical review of additional possible mechanisms in the pathogenesis of AIDS]: Pathologica. 1994 Apr;86(2):119-27. Unique Identifier : AIDSLINE MED/95022769; Legitimo A; Baldini M; Consolini R; Biver P; Crimaldi G; Macchia P; Istituto di Clinica Pediatrica, Universita di Pisa.; It is generally agreed that HIV itself has the primary role in the initiation and propagation of the pathogenic process of the infection. Nonetheless, a number of important issues concerning the pathogenesis of HIV infection remain unresolved. For example, it remains unclear how CD4+ T cells are lost after HIV infecti
Pediatric HIV infection: an imaging update.: Pediatr Radiol. 1994;24(3):224-30. Unique Identifier : AIDSLINE MED/95022825; Haller JO; Cohen HL; Department of Radiology, State University of New York/Health; Science Center at Brooklyn (Downstate Medical Center) 11203.; Infection with the human immunodeficiency virus (HIV) can produce a broad range of illness, including opportunistic infections, lymphoproliferative diseases, and benign and malignant neoplasms. Each conditions has its own spectrum of imaging findings. This paper will highlight those findings in children suffering from
Parenting and early development among children of drug-abusing women: effects of home intervention.: Pediatrics. 1994 Oct;94(4 Pt 1):440-8. Unique Identifier : AIDSLINE MED/95022869; Black MM; Nair P; Kight C; Wachtel R; Roby P; Schuler M; Department of Pediatrics, University of Maryland School of; Medicine, Baltimore 21201.; OBJECTIVE. To evaluate the efficacy of home intervention with drug-abusing women on parenting behavior and attitudes, and on children s development. DESIGN. A randomized, clinical trial of 60 drug-abusing women recruited prenatally and randomized into an intervention (n = 31) or comparison (n = 29) group. There were n
Clinical and pharmacokinetic evaluation of long-term therapy with didanosine in children with HIV infection.: Pediatrics. 1994 Nov;94(5):724-31. Unique Identifier : AIDSLINE MED/95022925; Mueller BU; Butler KM; Stocker VL; Balis FM; Brouwers P; Jarosinski P; Husson RN; Lewis LL; Venzon D; Pizzo PA; Pediatric Branch, Warren Grant Magnuson Clinical Center, National; Cancer Institute, Bethesda, MD 20892.; BACKGROUND. Didanosine has demonstrated promising antiviral activity and a tolerable toxicity profile in short term studies. We describe a cohort of HIV-infected children who were treated for a prolonged period of time with didanosine. METHODS. Children (6 months to 18 years of age) with symptomatic HIV infection or a
Panel advises governor on health care reform.: N J Nurse. 1994 Sep;24(7):11. Unique Identifier : AIDSLINE MED/95023017; Wachter MB
Healing rituals experienced by persons living with AIDS.: NLN Publ. 1994 May;(14-2607):241-51. Unique Identifier : AIDSLINE MED/95023031; Lakomy JM
[Norwegian infection control in modern Europe]: Nord Med. 1994;109(10):259-62. Unique Identifier : AIDSLINE MED/95023044; Dobloug JH; Infeksjonsmedisinsk avdeling, Ulleval sykehus, Oslo.; Infectious diseases are still a major health problem world wide. In Europe, however, and in Norway in particular, infectious diseases have not been a threat to public health for several years. In this paper, some of the major events in the European region which could have an impact
A three-nucleotide helix I is sufficient for full activity of a hammerhead ribozyme: advantages of an asymmetric design.: Nucleic Acids Res. 1994 Sep 25;22(19):3958-65. Unique Identifier : AIDSLINE MED/95023156; Tabler M; Homann M; Tzortzakaki S; Sczakiel G; Institute of Molecular Biology and Biotechnology, Foundation for; Research and Technology Hellas, Heraklion, Crete, Greece.; Trans-cleaving hammerhead ribozymes with long target-specific antisense sequences flanking the catalytic domain share some features with conventional antisense RNA and are therefore termed catalytic antisense RNAs . Sequences 5 to the catalytic domain form helix I and sequences 3 to it form helix III when complexed
RNA tertiary structure of the HIV RRE domain II containing non-Watson-Crick base pairs GG and GA: molecular modeling studies.: Nucleic Acids Res. 1994 Sep 25;22(19):3966-76. Unique Identifier : AIDSLINE MED/95023157; Le SY; Pattabiraman N; Maizel JV Jr; Laboratory of Mathematical Biology, Division of Cancer Biology,; Diagnosis and Centers, National Cancer Institute, NIH, Frederick,; MD 21702.; We have used molecular modeling techniques to model the RNA tertiary structure of the viral RNA element (referred to as domain II of Rev responsive element, RRE) bound by the Rev protein of HIV. In this study, the initial three-dimensional model was built from its established RNA secondary structure, including three n
Formation of a stable complex between the human immunodeficiency virus integrase protein and viral DNA.: Nucleic Acids Res. 1994 Oct 11;22(20):4103-10. Unique Identifier : AIDSLINE MED/95023177; Vink C; Lutzke RA; Plasterk RH; Division of Molecular Biology, Netherlands Cancer Institute,; Amsterdam.; The integrase (IN) protein of the human immunodeficiency virus (HIV) mediates two distinct reactions: (i) specific removal of two nucleotides from the 3 ends of the viral DNA and (ii) integration of the viral DNA into target DNA. Although IN discriminates between specific (viral) DNA and nonspecific DNA in physical i
Characterization of the minimal DNA-binding domain of the HIV integrase protein.: Nucleic Acids Res. 1994 Oct 11;22(20):4125-31. Unique Identifier : AIDSLINE MED/95023180; Lutzke RA; Vink C; Plasterk RH; Division of Molecular Biology, Netherlands Cancer Institute,; Amsterdam.; The human immunodeficiency virus (HIV) integrase (IN) protein mediates an essential step in the retroviral lifecycle, the integration of viral DNA into human DNA. A DNA-binding domain of HIV IN has previously been identified in the C-terminal part of the protein. We tested truncated proteins of the C-terminal region o
Confronting the stigma of AIDS.: Nurs Times. 1994 Aug 31-Sep 6;90(35):52-3. Unique Identifier : AIDSLINE MED/95023240; O'Keefe C
Midwives and HIV: the case for continuing education.: Nurs Times. 1994 Sep 7-13;90(36):48-9. Unique Identifier : AIDSLINE MED/95023253; Morley D; On a worldwide scale, HIV transmission figures continue to rise dramatically. This paper looks at the impact the pandemic is likely to have on women of childbearing age in the future. The author finds that if current statistical predictions are to become a reality, midwives and perinatal nursing staff are increasingly
WHO's global strategy for leprosy elimination.: Nurs J India. 1994 Feb;85(2):38-41. Unique Identifier : AIDSLINE MED/95023269
Healthcare reform: past and future.: Oncol Nurs Forum. 1994 Jun;21(5):827-32. Unique Identifier : AIDSLINE MED/95023294; McDermott KC; Memorial Sloan-Kettering Cancer Center, New York, NY.; PURPOSE: To review changes in the healthcare delivery system and project the challenges that practitioners and consumers will face in a reformed environment. DATA SOURCES: Professional journals and books, print media, and government releases. DATA SYNTHESIS: Analysis of projected reform plans, discussions of issues re
Pneumocystis carinii pneumonia prophylaxis during pregnancy.: Pharmacotherapy. 1994 Jul-Aug;14(4):424-9. Unique Identifier : AIDSLINE MED/95023330; Connelly RT; Lourwood DL; Department of Infectious Diseases, Rush-Presbyterian-St. Luke's; Medical Center, Chicago, Illinois.; The frequency of human immunodeficiency virus (HIV) infection among pregnant women is increasing. Pneumocystis carinii pneumonia (PCP) is the most common opportunistic infection in HIV-infected patients, and prophylaxis is an important part of decreasing morbidity. Trimethoprim-sulfamethoxazole (TMP-SMX), pentamidine,
Oral and dermatologic manifestations of HIV infection.: Postgrad Med. 1994 Oct;96(5):105-8, 111, 114-6. Unique Identifier : AIDSLINE MED/95023468; Jewell ME; Sweet DE; Department of Internal Medicine, University of Kansas School of; Medicine--Wichita.; Because an estimated 1 million persons in the United States are infected with HIV, all physicians, especially those in primary care, need to be able to recognize the protean manifestations of the disease and make a diagnosis as early as possible. In this article, Drs Jewell and Sweet r
HIV and the work intentions of public health nurses [published erratum appears in Public Health Nurs 1994 Dec;11(6):following 430]: Public Health Nurs. 1994 Aug;11(4):273-80. Unique Identifier : AIDSLINE MED/95023563; Tessaro I; Highriter M; School of Public Health, University of North Carolina at Chapel; Hill.; Studies have examined the association between attitudes about the human immunodeficiency virus (HIV) and nurses willingness or intentions to work with infected persons. However, the relationship between these intentions and perceived concern from nurses family and friends, or factors of professional nursing experien
Percutaneous absorption of 2',3'-dideoxyinosine in rats.: Pharm Res. 1994 Jun;11(6):809-15. Unique Identifier : AIDSLINE MED/95023580; Mukherji E; Millenbaugh NJ; Au JL; College of Pharmacy, Ohio State University, Columbus 43210.; This study explored the topical route for administering of 2 ,3 -dideoxyinosine (ddI), a nucleoside analog used for treating patients with acquired immunodeficiency syndrome. A dose of ddI (approximately 180 mg/kg) dispersed in approximately 1 g ointment base was applied, with or without occlusion, to the back of high
[Teratocarcinoma with pericardial extension in an AIDS patient (letter)]: Presse Med. 1994 May 14;23(18):859-60. Unique Identifier : AIDSLINE MED/95023677; Jacomet C; Maslo C; Boulleuc C; Lebrette MG; Rozenbaum W
[Intracerebral tuberculoma in HIV infection. Epidemiology and contribution of magnetic resonance imaging]: Presse Med. 1994 May 21;23(19):891-5. Unique Identifier : AIDSLINE MED/95023686; Lecuit M; Rogeaux O; Bricaire F; Gentilini M; Service des Maladies infectieuses, parasitaires et tropicales.; Groupe hospitalier Pitie-Salpetriere, Paris.; Intracerebral tuberculomas, observed in two HIV-infected patients, illustrated the diagnostic and therapeutic problems involved when an intracranial formation is discovered in this clinical situation. Both patients had a history of pulmonary tuberculosis. No preventive treatment had been given and disseminated tubercu
[Cerebral toxoplasmosis in AIDS: efficacy and good tolerance of cotrimoxazole (letter) (see comments)]: Presse Med. 1994 May 21;23(19):907. Unique Identifier : AIDSLINE MED/95023689; Smadja D; Lin L; Cidolit E; Neisson-Vernant C; Cabre P; Vernant JC
[Rheumatoid purpura revealing seroconversion in human immunodeficiency virus infection (letter)]: Presse Med. 1994 May 21;23(19):910. Unique Identifier : AIDSLINE MED/95023694; Boissier L; Brousse C; Piette AM; Gepner P; Chapman A
[Pulmonary pneumocystosis revealing HIV infection (letter)]: Presse Med. 1994 May 28;23(20):951. Unique Identifier : AIDSLINE MED/95023703; Luchon L; Couderc LJ; Stern M; Friard S; Caubarrere I
[Streptococcus pneumoniae bacteremia and HIV infection. Retrospective study of 41 episodes in 30 patients]: Presse Med. 1994 Jun 4;23(21):972-5. Unique Identifier : AIDSLINE MED/95023711; Torri O; Mariel C; Veyssier P; Cevallos R; Bouchaud O; Carbon C; Jarousse B; Masson H; Patey O; Fantin B; Service du Dr Veyssier, Hopital de Compiegne.; OBJECTIVES: Pulmonary infections and bacteraemia, essentially due to Streptococcus pneumoniae and Haemophilus influenzae, are frequently reported in patients infected with the human immunodeficiency virus (HIV). We retrospectively analyzed episodes of bacteraemia in HIV-infected patients to determine whether supplemen
[Guillain-Barre syndrome associated with cytomegalovirus infection after kidney transplantation]: Presse Med. 1994 Jun 4;23(21):976-8. Unique Identifier : AIDSLINE MED/95023712; Lloveras JJ; Larrue V; Delisle MB; Tack I; Icart J; Dupre C; Ton That H; Durand D; Suc JM; Service de Nephrologie, CHU Rangueil, Toulouse.; The Guillain-Barre syndrome associated with cytomegalovirus infection is a recognized entity of unknown pathogenesis. We observed two characteristic cases with acute polyradiculoneuropathy which occurred after renal transplantation. Both patients fulfilled the diagnostic criteria f
[Medullary toxoplasmic abscess in an AIDS patient (letter)]: Presse Med. 1994 Jun 4;23(21):995. Unique Identifier : AIDSLINE MED/95023717; Bossi P; Sadik JC; Flament-Saillour M; Hassine D; De Truchis P
[Anti-lymphocyte antibodies in HIV infection (letter)]: Presse Med. 1994 Jun 4;23(21):998. Unique Identifier : AIDSLINE MED/95023722; Ritter J; Monier JC
Analysis of Epstein-Barr virus-encoded small RNA 1 expression in benign lymphoepithelial salivary gland lesions.: Mod Pathol. 1994 Jun;7(5):555-9. Unique Identifier : AIDSLINE MED/95023855; DiGiuseppe JA; Wu TC; Corio RL; Department of Pathology, Johns Hopkins Medical Institutions,; Baltimore, Maryland.; Salivary gland enlargement resulting from benign lymphoepithelial lesions may be seen in patients with Sjogren s syndrome (SS) and in the early stages of human immunodeficiency virus (HIV) infection. Although the pathogenesis of these lesions is thought to differ in SS and HIV infection, Epstein-Barr virus (EBV) has b
Tethering human immunodeficiency virus 1 integrase to a DNA site directs integration to nearby sequences.: Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9233-7. Unique Identifier : AIDSLINE MED/95023885; Bushman FD; Salk Institute for Biological Studies, La Jolla, CA 92037.; Certain retrovirus and retrotransposons display strong biases in the selection of host DNA sites for integration. To probe the possibility that simple tethering of the retroelement integrase protein to a target DNA site is sufficient to direct integration, the activities of a hybrid composed of human immunodeficiency
CD8+ T cells in psoriatic lesions preferentially use T-cell receptor V beta 3 and/or V beta 13.1 genes.: Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9282-6. Unique Identifier : AIDSLINE MED/95023895; Chang JC; Smith LR; Froning KJ; Schwabe BJ; Laxer JA; Caralli LL; Kurland HH; Karasek MA; Wilkinson DI; Carlo DJ; et al; Immune Response Corporation, Carlsbad, CA 92008.; Psoriasis is an inflammatory skin disorder characterized by epidermal keratinocyte hyperproliferation in association with a cellular infiltrate. There is evidence that activated T cells play a role in psoriatic plaque formation. We examined the T-cell receptor beta-chain variable gene segment (V beta) use of epidermal
Transcriptional activation in vitro by the human immunodeficiency virus type 1 Tat protein: evidence for specific interaction with a coactivator(s).: Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9357-61. Unique Identifier : AIDSLINE MED/95023910; Song CZ; Loewenstein PM; Green M; Institute for Molecular Virology, Saint Louis University Health; Sciences Center, MO 63110.; The Tat protein encoded by human immunodeficiency virus type 1 is a strong transcriptional activator of gene expression from the viral long terminal repeat and is essential for virus replication. We have investigated the molecular mechanism of Tat trans-activation by using a cell-free transcription system. We find tha
Programmed cell death and AIDS: significance of T-cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections.: Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9431-5. Unique Identifier : AIDSLINE MED/95023925; Estaquier J; Idziorek T; de Bels F; Barre-Sinoussi F; Hurtrel B; Aubertin AM; Venet A; Mehtali M; Muchmore E; Michel P; et al; Institut National de la Sante et de la Recherche Medicale; (INSERM) U415, Institut Pasteur, Lille, France.; We have proposed that inappropriate induction of programmed cell death (PCD) or apoptosis, a physiological cell-suicide process, may play a role in the pathogenesis of AIDS. This model has been supported by several reports of abnormal levels of PCD in vitro in both CD4+ and CD8+ T cells from human immunodeficiency vir
Killing of primary CD4+ T cells by non-syncytium-inducing macrophage-tropic human immunodeficiency virus type 1.: Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10237-41. Unique Identifier : AIDSLINE MED/95024020; Yu X; McLane MF; Ratner L; O'Brien W; Collman R; Essex M; Lee TH; Department of Cancer Biology, Harvard School of Public Health,; Boston, MA 02115.; Understanding the mechanism by which human immunodeficiency virus type 1 (HIV-1) kills CD4+ T lymphocytes is important to the development of therapeutic and prophylactic strategies. Recent studies have indicated that, in some cases, progression to AIDS is associated with the appearance of syncytium-inducing, T cell li
Ribozyme-mediated suppression of Moloney murine leukemia virus and human immunodeficiency virus type I replication in permissive cell lines.: Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9715-9. Unique Identifier : AIDSLINE MED/95024031; Sun LQ; Warrilow D; Wang L; Witherington C; Macpherson J; Symonds G; R.W. Johnson Pharmaceutical Research Institute-Sydney, New South; Wales, Australia.; Several hammerhead ribozymes targeted to different sites within the retroviral packaging (psi) sequences of the Moloney murine leukemia virus (Mo-MLV) and the human immunodeficiency virus type 1 (HIV-1) were designed and shown to cleave target RNA in vitro at the chosen sites. The engineered ribozymes, as well as anti
Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection.: Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9770-4. Unique Identifier : AIDSLINE MED/95024042; Wild CT; Shugars DC; Greenwell TK; McDanal CB; Matthews TJ; Department of Surgery, Duke University Medical Center, Durham, NC; 27710.; To define the role of the human immunodeficiency virus type 1 (HIV-1) envelope proteins in virus infection, a series of peptides were synthesized based on various regions of the HIV-1 transmembrane protein gp41. One of these peptides, DP-178, corresponding to a region predictive of alpha-helical secondary structure (r
Attenuated Mengo virus as a vector for immunogenic human immunodeficiency virus type 1 glycoprotein 120.: Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9775-9. Unique Identifier : AIDSLINE MED/95024043; Altmeyer R; Escriou N; Girard M; Palmenberg A; van der Werf S; Unite de Virologie Moleculaire, Institut Pasteur, Paris,; France.; Introduction of a sequence encoding 147 amino acids from human immunodeficiency virus type I (HIV-1) strain MN glycoprotein gp120 into the RNA genome of the stably attenuated Mengo virus strain vM16 yielded an infectious recombinant virus, vMLN450, which expressed the heterologous HIV-1 sequence along with the normal
Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.: Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9866-70. Unique Identifier : AIDSLINE MED/95024062; Sedegah M; Hedstrom R; Hobart P; Hoffman SL; Malaria Program, Naval Medical Research Institute, Bethesda, MD; 20889-5607.; Immunization with irradiated sporozoites protects animals and humans against malaria, and the circumsporozoite protein is a target of this protective immunity. We now report that adjuvant-free intramuscular injection of mice with plasmid DNA encoding the Plasmodium yoelii circumsporozoite protein induced higher levels
Role of CD26/dipeptidyl peptidase IV in human immunodeficiency virus type 1 infection and apoptosis.: Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9960-4. Unique Identifier : AIDSLINE MED/95024081; Morimoto C; Lord CI; Zhang C; Duke-Cohan JS; Letvin NL; Schlossman SF; Division of Tumor Immunology, Dana-Farber Cancer Institute,; Boston, MA.; To examine the role of CD26/dipeptidyl peptidase IV (DPPIV; EC 3.4.14.5) in infection by human immunodeficiency virus type 1 (HIV-1), we utilized CD26 cDNA-transfected Jurkat T-cell lines. Both CD26- parental Jurkat cells and mutant CD26+ (DPPIV-) transfected Jurkat cells were readily infected with HIV-1, whereas wild
Activation of the human immunodeficiency virus long terminal repeat in THP-1 cells by a staphylococcal extracellular product.: Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10615-9. Unique Identifier : AIDSLINE MED/95024165; Klebanoff SJ; Kazazi F; Van Voorhis WC; Schlechte KG; Department of Medicine, University of Washington, Seattle 98195.; Staphylococcal strains can release a factor that strongly activates the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in THP-1 cells transfected with the HIV-1 LTR-driven luciferase reporter gene (THP-1 LTRluc). The factor is present in the overnight culture fluid and is readily released from
Interleukin 12 induction of interferon gamma-dependent protection against malaria.: Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10700-2. Unique Identifier : AIDSLINE MED/95024182; Sedegah M; Finkelman F; Hoffman SL; Malaria Program, Naval Medical Research Institute, Bethesda, MD; 20889-5607.; Intraperitoneal injection of recombinant Interleukin 12 (rIL-12) at 30 ng/day for 5 days beginning 1 to 2 days before sporozoite challenge or administration of a single dose of 150 ng of rIL-122 days before challenge protected 100% of BALB/c mice against challenge with 10(2) Plasmodium yoelii sporozoites. rIL-12-induc
Virologic and genetic studies relate Amerind origins to the indigenous people of the Mongolia/Manchuria/southeastern Siberia region.: Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10737-41. Unique Identifier : AIDSLINE MED/95024190; Neel JV; Biggar RJ; Sukernik RI; Department of Human Genetics, University of Michigan Medical; School, Ann Arbor 48109-0618.; A commonly held theory is that the first wave of migrants into the New World was derivative from the ethnic groups then inhibiting eastern Siberia. However, these ethnic groups lack a mtDNA haplogroup (B) that is well represented in Amerindian tribes. Also, the time depth of the other three mtDNA haplogroups found in
Same problems, different system? A UK perspective of infection control in an American hospital.: Prof Nurse. 1994 Sep;9(12):790-7. Unique Identifier : AIDSLINE MED/95024230; Kingston JE; 1. Infection control practitioners are at the forefront of enforcement of infection control procedures in the US. 2. HIV infection is cited as the single most prominent cause of increases in cases of TB in most US health departments. 3. Attention to record keeping is an area in which infection control practitioners in
Molecular mechanism of retroviral DNA integration.: Pharmacol Ther. 1994;61(1-2):185-203. Unique Identifier : AIDSLINE MED/95024344; Kulkosky J; Skalka AM; Institute for Cancer Research, Fox Chase Cancer Center,; Philadelphia, PA 19111.; The integration of retroviral DNA appears to be obligatory for the efficient replication of retroviruses in their respective host cells. During a natural infection, integration takes place in a process that includes biochemically and temporally discrete steps. These are: (1) the removal of two nucleotides from the 3
New phthalocyanines for photodynamic virus inactivation in red blood cell concentrates.: Photochem Photobiol. 1994 Aug;60(2):165-70. Unique Identifier : AIDSLINE MED/95024390; Rywkin S; Ben-Hur E; Malik Z; Prince AM; Li YS; Kenney ME; Oleinick NL; Horowitz B; Lindsay F. Kimball Research Institute, New York Blood Center, NY; 10021.; Cationic phthalocyanines with either aluminum or silicon as the central metal were evaluated for their ability to inactivate viruses in red blood cell concentrates (RBCC) photodynamically. In addition, the virucidal potential of a substituted anionic phthalocyanine, aluminum dibenzodisulfophthalocyanine hydroxide (A1N
HIV prevention in prisons and jails: obstacles and opportunities.: Public Health Rep. 1994 Sep-Oct;109(5):615-25. Unique Identifier : AIDSLINE MED/95024558; Polonsky S; Kerr S; Harris B; Gaiter J; Fichtner RR; Kennedy MG; Public Health Service's Centers for Disease Control and; Prevention, Division of STD/HIV Prevention, Atlanta, GA 30333.; High rates of human immunodeficiency virus (HIV) infection among jail and prison inmates suggest that HIV prevention efforts should focus on incarcerated populations. Overcrowding, the high prevalence of injection drug use, and other high-risk behaviors among inmates create a prime opportunity for public health offici
Perceived versus actual condom skills among clients at sexually transmitted disease clinics.: Public Health Rep. 1994 Sep-Oct;109(5):683-7. Unique Identifier : AIDSLINE MED/95024567; Langer LM; Zimmerman RS; Cabral RJ; Department of Sociology and Anthropology, Florida International; University, Miami 33199.; The primary aim of this study was to investigate whether individual self-reports of perceived ability to use a condom correctly correlated with the actual ability to do so. Participants in the study were 3,059 clients of a sexually transmitted disease clinic. The findings revealed that the participants perceived self
Misdiagnosed HIV infection in pregnant women: implications for clinical care.: Public Health Rep. 1994 Sep-Oct;109(5):694-9. Unique Identifier : AIDSLINE MED/95024569; Sheon AR; Fox HE; Alexander G; Buck A; Higgins A; McDermott SM; Moroso G; Moye J; Pacheco-Acosta E; Division of AIDS, National Institute of Allergy and Infectious; Diseases, National Institutes of Health, Rockville, MD 20892.; Out of nearly 900 women in a research study of human immunodeficiency virus infection in pregnancy, 8 were subsequently found not to be infected. Misdiagnoses could have resulted from (a) laboratory errors or specimen mixups; (b) failure to follow the testing algorithm recommended by the Centers for Disease Control an
Comparison of HIV-risk behaviors and demographics of adolescents tested or not tested for HIV infection.: Public Health Rep. 1994 Sep-Oct;109(5):699-702. Unique Identifier : AIDSLINE MED/95024570; Main DS; Iverson DC; McGloin J; Center for Studies in Family Medicine, University of Colorado; Health Sciences Center, Denver 80220.; In a survey of 2,548 adolescents, 11.5 percent reported ever having had the human immunodeficiency virus (HIV) antibody test. Those who had been tested were significantly more likely to be male, black, and to reside in metropolitan areas than those who had not been tested. Tested adolescents were more than three times
AZT reduces maternal HIV transmission rate [news]: Public Health Rep. 1994 Sep-Oct;109(5):718. Unique Identifier : AIDSLINE MED/95024574
Identification of Mycobacterium avium and Mycobacterium intracellulare isolated in Puerto Rico from clinical samples by the use of a non-radioactive DNA probe.: P R Health Sci J. 1994 Jun;13(2):129-32. Unique Identifier : AIDSLINE MED/95024576; Garcia MT; Pena I; Zlotnik H; Clinical Microbiology Laboratory, Department of Veterans Affairs,; San Juan, P.R. 00927-5800.; The Mycobacterium avium complex (MAC), especially M. avium, is an important opportunistic pathogen of AIDS patients in the United States . In Puerto Rico , the incidence of infections caused by MAC has not been determined. This is due, in part, to
HIV/AIDS risk perception, HIV risk behaviors, and HIV seropositivity among injection drug users in Puerto Rico.: P R Health Sci J. 1994 Jun;13(2):153-8. Unique Identifier : AIDSLINE MED/95024579; Cancel LI; Robles RR; Colon HM; Matos TD; Freeman DH; Research Institute, Mental Health and Anti Addiction Services; Administration, Commonwealth of Puerto Rico, San Juan 00928-1414.; This paper assesses the factors related to self perception of developing AIDS among a group of 1,568 Puerto Rican injection drug users (IDUs). Incarceration history, years of drug injection, sharing needles, renting and borrowing needles, sharing rinse water or cooker, and having an IDU sex partner yielded a moderate
Why do cells die in HIV infection? Potential mechanisms inducing programmed cell death/apoptosis.: P R Health Sci J. 1994 Jun;13(2):79-124. Unique Identifier : AIDSLINE MED/95024581; Del Llano AM; Lavergne JA; Department of Biology, Humacao Campus, University of Puerto Rico.; This work reviews the suggested mechanisms which result in programmed cell death in human HIV infection. Here we present state-of-the-art scientific information related to the newly rediscovered phenomenon of Apoptosis, and to its biological relevance in the pathogenesis of HIV disease. General features of this phenom
Gingival and periodontal alterations associated with infection with human immunodeficiency virus.: Quintessence Int. 1994 Jun;25(6):375-87. Unique Identifier : AIDSLINE MED/95024603; Langford A; Department of Maxillofacial Surgery, Free University of Berlin,; Germany.; Various changes may occur in the gingiva and/or the periodontium as an expression of existing infection with human immunodeficiency virus. Thus, periodontal disease, characterized by unusual course, progress, and resistance to treatment, may occur with increased frequency. Clinically, pseudomembranous or erythematous
Effects of gamma rays, ultraviolet radiation, sunlight, microwaves and electromagnetic fields on gene expression mediated by human immunodeficiency virus promoter.: Radiat Res. 1994 Oct;140(1):91-6. Unique Identifier : AIDSLINE MED/95024638; Libertin CR; Panozzo J; Groh KR; Chang-Liu CM; Schreck S; Woloschak GE; Center for Mechanistic Biology and Biotechnology, Argonne; National Laboratory, Illinois 60439-4833.; Previous work by our group and others has shown the modulation of human immunodeficiency virus (HIV) promoter or long terminal repeat (LTR) after exposure to neutrons and ultraviolet radiations. Using HeLa cells stably transfected with a construct containing the chloramphenicol acetyl transferase (CAT) gene, the trans
[The molecular biology of oral tolerance]: Tanpakushitsu Kakusan Koso. 1994 Sep;39(12):2090-101. Unique Identifier : AIDSLINE MED/95024796; Kaminogawa S; Hisatsune T; Hachimura S; Department of Applied Biological Chemistry, University of Tokyo,; Japan.
Study analyzes possible transmission of HIV.: RDH. 1994 Apr;14(4):30. Unique Identifier : AIDSLINE MED/95024879; Miller C; Department of Oral Microbiology, Sterilization and Monitoring; Service, Indiana University.
[Mycoplasmas as pathogenic agents in humans. Current findings. (editorial)]: Rev Clin Esp. 1994 Jul;194(7):519-22. Unique Identifier : AIDSLINE MED/95025025; Meseguer Peinado MA
[Detection of HIV antibodies in saliva using a rapid diagnostic immunoenzyme assay]: Rev Clin Esp. 1994 Jul;194(7):523-5. Unique Identifier : AIDSLINE MED/95025026; Fernandez Rodriguez E; Carcaba Fernandez V; Rodriguez Junquera M; Alfonso Megido J; Garcia Amorin Z; Garcia Alonso S; Servicio de Analisis Clinicos, Hospital Valle del Nalon,; Langreo, Asturias.; The usefulness of an enzyme-immunoassay (EIA) monotest (TESTPACK HIV-1/HIV-2, ABBOTT) was evaluated in the rapid diagnosis of anti-HIV antibodies in whole saliva in an intravenous drug abuser population (IVDA). Anti-HIV antibodies were simultaneous and prospectively measured in serum and whole saliva from 70 IVDA pati
[Human immunodeficiency virus infection in an emergency department]: Rev Clin Esp. 1994 Jul;194(7):526-9. Unique Identifier : AIDSLINE MED/95025027; Echevarria S; Hernandez M; Paz I; Galarraga C; Ledesma F; Martinez Bernal MA; Servicio de Microbiologia, Hospital Universitario Marques de; Valdecilla, Facultad de Medicina, Universidad de Santander.; Unlabeled serum samples from patients attended at the Emergency Department of our Hospital were collected for a 10-week period to measure the presence of anti-HIV antibodies and assess the prevalence of the infection in this population. Both suspected (with warning mark on samples) and non-suspected patients of having
[Study of 164 episodes of infectious endocarditis in drug addicts: comparison of HIV positive and negative patients (see comments)]: Rev Clin Esp. 1994 Jul;194(7):535-9. Unique Identifier : AIDSLINE MED/95025029; Valencia ME; Guinea J; Soriano V; Martinez ML; Moreno V; Laguna F; Enriquez A; Gonzalez Lahoz J; Servicio de Enfermedades Infecciosas, CIC, Instituto de Salud; Carlos III, Madrid.; OBJECTIVE. Intravenous drug-addicts (IVDA) are the most important risk group for acquiring HIV and developing infective endocarditis (IE) in Spain . The clinical and evolutive features of a large series of IE in HIV-infected IVDA are reported and compared with those observed in a sma
[Hodgkin's disease and HIV: relations between CD4/CD8 rate, histology and stage]: Rev Clin Esp. 1994 Jul;194(7):543-6. Unique Identifier : AIDSLINE MED/95025031; Rodriguez JN; Aguayo DM; Martin I; Dieguez JC; Prados D; Pujol E; Servicio de Hematologia, Hospital Juan Ramon Jimenez, Huelva.; Hodgkin s disease (HD) is not currently accepted as an AIDS diagnostic criterion by the Centers for Disease Control (Atlanta), although there are reports on a higher incidence of the disease in HIV infected patients, with the special feature of a marked clinical and histological aggressiveness. A review of the literat
[Rapidly evolving pulmonary bullous degeneration in HIV-infected patients. Description of 4 cases and review of the literature]: Rev Clin Esp. 1994 Jul;194(7):547-50. Unique Identifier : AIDSLINE MED/95025032; Prada Pardal JL; Villanueva Marcos JL; Kindelan Jaquotot JM; Jurado Jimenez R; Escribano Fernandez J; Sanchez Guijo P; Torre-Cisneros J; Unidad de Enfermedades Infecciosas, Hospital Universitario Reina; Sofia, Cordoba.; Cavitary lung lesions are common in intravenous drug-addicts (IVDA) and in AIDS patients. Four cases are reported of IVDA patients with HIV positive serology who developed an initially thick-walled lesion, which grew rapidly and evolved into bullous lesions. The negative results in microbiological investigations for P
[HTLV-I]: Rev Clin Esp. 1994 Jul;194(7):551-7. Unique Identifier : AIDSLINE MED/95025033; Soriano V; Gutierrez M; Tuset C; Calderon E; Servicio de Enfermedades Infecciosas, Instituto de Salud Carlos; III, Madrid.
[Serological diagnosis of HIV-1 infection]: Rev Clin Esp. 1994 Jul;194(7):558-67. Unique Identifier : AIDSLINE MED/95025034; Soriano V; Gutierrez M; Bravo R; Servicio de Enfermedades Infecciosas, Centro de Investigaciones; Clinicas, Instituto de Salud Carlos III, Madrid.
[Porphyria cutanea tarda and human immunodeficiency virus infection. Apropos of 2 further cases (letter)]: Rev Clin Esp. 1994 Jul;194(7):583-4. Unique Identifier : AIDSLINE MED/95025040; Belda Mira A; Rovira Daudi E; Diaz Sanchez F; Michavila Gomez J
[Low ADA levels in pleural tuberculosis in HIV-seropositive patients (letter)]: Rev Clin Esp. 1994 Jul;194(7):585. Unique Identifier : AIDSLINE MED/95025042; Villena MV; Echave-Sustaeta J; Lopez Encuentra A; Martin Escribano P; Navarro JA
[The dentist risk (editorial)]: Recenti Prog Med. 1994 Sep;85(9):413-4. Unique Identifier : AIDSLINE MED/95025078; Bonomo L
[Prevention of AIDS in drug addicts in Switzerland: an encouraging development]: Schweiz Rundsch Med Prax. 1994 Aug 23;83(34):916-20. Unique Identifier : AIDSLINE MED/95025255; Dubois-Arber F; Jeannin A; Meystre-Agostino G; Gruet F; Paccaud F; Institut universitaire de medecine sociale et preventive/UEPP; Lausanne.; Switzerland has adopted a prevention strategy including the promotion of non-sharing injection material and use of condoms. The access to sterile equipment has been made easier, but regional differences still exist. Studies conducted between 1989 and 1992 among drug users in d
[AIDS at the dawn of the 3rd millennium: epidemic of the misliked]: Rev Med Suisse Romande. 1994 Aug;114(8):723-9. Unique Identifier : AIDSLINE MED/95025314; Tarantola D; Programme international sur le SIDA, Francois-Xavier Bagnoud; Center for Health and Human Rights, Harvard School of Public; Health, Cambridge, MA 02138.
Sleep apnea and vigilance performance in a community-dwelling older sample.: Sleep. 1994 Apr;17(3):248-52. Unique Identifier : AIDSLINE MED/95025342; Ingram F; Henke KG; Levin HS; Ingram PT; Kuna ST; Harbourview Sleep Laboratory, League City, Texas 77573.; Impaired vigilance performance has been reported in older subjects with sleep apnea syndrome (SAS). The current study is an attempt to extend these findings and to investigate additional factors that might have implications for vigilance in the older adult. Fifty-nine older adults [age: 62 +/- 5 (mean +/- SD), range 5
Current notions of genotype and phenotype vis-a-vis new experimental evidence in molecular biology. A methodological study instigated by the peculiar nature of the HIV-1.: Riv Biol. 1993;86(2):155-9, 181-96. Unique Identifier : AIDSLINE MED/95025371; Torres JM; Centro de Logica y Filosofia de la Ciencia, Universidad; Nacional del Sur, Bahia Blanca, Argentina.; The strict separation of the biological roles of information and function as if they were two mutually exclusive aspects and the absolute identification of the former with nucleic acids and the latter with coded protein machinery has biased biological thinking to the extent that these notions act as very principles in
[New bacterial infections in the course of AIDS]: Rev Prat. 1994 May 15;44(10):1333-8. Unique Identifier : AIDSLINE MED/95025415; Rousseau MC; Brouqui P; Raoult D; Service des maladies tropicales et infectieuses, hopital; Houphouet-Boigny, Faculte de medecine, Marseille.; The authors reviewed the recent data on unusual or newly described bacterial infection in AIDS. Mycoplasma species are frequently associated with AIDS and hypothesized to play as a cofactor in AIDS evolution (Mycoplasma fermentans and Mycoplasma penetrans). Rochalimea henselea and Rochalimea quintana are the agents of
[Renal involvements in human immunodeficiency virus infection]: Rev Prat. 1994 Jun 1;44(11):1494-9. Unique Identifier : AIDSLINE MED/95025443; Nochy D; Glotz D; Goucha R; Pelletier L; Bariety J; Unite INSERM U28, service d'anatomie pathologique et de; nephrologie, hopital Broussais, Paris.; Two main types of renal disorder may affect the HIV-infected patients. The first type characterized by acute renal failure is not related directly to HIV infection, but results from complications secondary to diagnosis and therapeutic intervention in patients with severe immunodepression. The second type of renal comp
[Human immunodeficiency virus infection in children]: Rev Prat. 1994 Jun 15;44(12):1603-10. Unique Identifier : AIDSLINE MED/95025459; Blanche S; Departement de pediatrie, hopital des Enfants Malades, Paris.; Four hundred to 600 pregnancies have now been carried to full-term by HIV seropositive women in France . The rate of transmission of the virus to the infant is around 20%, and there remains much uncertainty concerning the exact mechanism involved. Early diagnostic methods are based
[New macrolides]: Rev Prat. 1994 Jun 15;44(12):1629-34. Unique Identifier : AIDSLINE MED/95025462; Portier H; Buisson M; Chavanet P; Service des maladies infectieuses et tropicales, CHU du Bocage,; Dijon.; The macrolides are still widely used in general practice and the new 14- or 15 membered-ring compounds-roxithromycin, clarithromycin, dirithromycin, azithromycin -may offer a new development. Their antibacterial activity is similar to erythromycin but azithromycin is more active against Gram negative strams. Roxythrom
[Antiretroviral treatments in human immunodeficiency virus infection]: Rev Prat. 1994 Jun 15;44(12):1635-42. Unique Identifier : AIDSLINE MED/95025463; Dormont J; Aboulker JP; Service de medecine interne et de reanimation, hopital; Antoine-Beclere, Clamart.; Antiretroviral drugs already registered or currently in clinical trials are shortly described, including dideoxynucleosides, non-nucleoside reverse transcriptase inhibitors, protease inhibitors , tat inhibitors and antisens molecules. In a second part, the treatment
[Primary and secondary syphilis. Epidemiology, diagnosis, treatment]: Rev Prat. 1994 Jun 15;44(12):1685-8. Unique Identifier : AIDSLINE MED/95025471; Joly V; Cremieux AC; Carbon C; Service de medecine interne, groupe hospitalier Bichat-Claude; Bernard, Paris.
[A new virus: the human herpesvirus 6]: Rev Prat. 1994 Apr 1;44(7):871-4. Unique Identifier : AIDSLINE MED/95025520; Agut H; Aubin JT; Laboratoire de virologie, CNRS EP 57, CERVI, hopital; Pitie-Salpetriere, Paris.; Human herpesvirus 6 (HHV-6) was discovered in 1986. This novel virus is genetically related to cytomegalovirus . HHV-6 mainly infects T lymphocytes but its tropism appears to be much wider and probably involves some epithelial cells. Two HHV-6 variants, designated as A and B, can be
[A new opportunistic infection: microsporidiosis]: Rev Prat. 1994 Apr 1;44(7):877-81. Unique Identifier : AIDSLINE MED/95025521; Molina JM; Clinique des maladies infectieuses et tropicales, hopital; Saint-Louis, Paris.; Microsporidiosis is a recently identified opportunistic infection in patients with AIDS. Microsporidie usually induce chronic diarrhoeas, cachexia, and cholangitis. Disseminated infection with pulmonary or renal involvement and sinusitis has also been described. Rarely, conjunctivitis can occur. Diagnosis now relies o
[Present status of retroviruses in human infectious disease]: Rev Prat. 1994 Apr 1;44(7):888-93. Unique Identifier : AIDSLINE MED/95025523; Seigneurin JM; Perron H; Laboratoire de virologie, Faculte de medecine de Grenoble,; Domaine de la Merci, La Tronche.; Retroviruses have been shown to be oncogenic in many animals for decades. In humans, retroviruses became worth of interest no sooner than in the early eighties. HIV is at the moment the last one of the well studied human retroviruses. Besides, HTLV-1, the prevalence of which is geographically restricted, is associated
[Virus and human oncogenesis]: Rev Prat. 1994 Apr 1;44(7):900-5. Unique Identifier : AIDSLINE MED/95025525; Bourhis J; Dupuis O; Institut Gustave-Roussy (radiotherapie et pharmacologie; moleculaire), Villejuif.; Only a limited number of human viruses have been shown to have oncogenic properties, including the retrovirus HTLV1 and 2, the hepatitis B virus (HBV), the Epstein-Barr virus (EBV), and some human papillomas virus (HPV). Epidemiologic and molecular biological studies have shown that these viruses were involved as cofa
[The past, present and future of arterial infection]: Rev Prat. 1994 Apr 1;44(7):906-10. Unique Identifier : AIDSLINE MED/95025526; Capron L; Loire R; Service de medecine vasculaire, hopital Broussais, Paris.; Today, the pathology of large and medium-sized arteries is in most part considered as degenerative or inflammatory. The role of infection has been preponderant (syphilis) but has become quite modest now, restricted to infectious aneurysms. According to certain observations, infections may participate in initiating art
[Thoracic imaging in AIDS]: Rev Prat. 1994 Apr 15;44(8):1056-67. Unique Identifier : AIDSLINE MED/95025549; Carette MF; Mayaud C; Bigot JM; Service de radiologie du Pr JM Bigot, hopital Tenon, Paris.; Chest complications were the first known in AIDS; even, Pneumocystis carinii pneumonia was the initial warning light. At the present time lung complications remain the major cause of death in such patients. A better knowledge of these pathologies often allows to pass an acute episode and perhaps to prevent infectious
[HIV infection. Modes of transmission, etiology, detection, prevention, treatment]: Rev Prat. 1994 May 1;44(9):1263-71. Unique Identifier : AIDSLINE MED/95025580; Choutet P; Besnier JM; Service des maladies infectieuses, hopital Bretonneau, CHU,; Tours.
The role of CD4+ T cells in cell-mediated immunity to LCMV: studies in MHC class I and class II deficient mice.: Scand J Immunol. 1994 Oct;40(4):373-82. Unique Identifier : AIDSLINE MED/95025636; Christensen JP; Marker O; Thomsen AR; Institute of Medical Microbiology and Immunology, University of; Copenhagen, Panum Institute, Denmark.; Parameters of the virus-specific T-cell response were analysed in order to dissect the contribution of CD4+ and CD8+ T cells to cell-mediated immunity to lymphocytic choriomeningitis virus. In MHC class II deficient mice, initial T-cell responsiveness was not impaired, but virus clearance was delayed, and virus-specif
Analysis of the capacity to produce IL-3 in murine AIDS.: Scand J Immunol. 1994 Oct;40(4):410-4. Unique Identifier : AIDSLINE MED/95025641; Neuenschwander AU; Marker O; Thomsen AR; Institute of Medical Microbiology and Immunology, University of; Copenhagen, Denmark.; Adult C57BL/6 mice infected with LP-BM5 murine leukaemia virus represent a model of murine AIDS (MAIDS). In this study we have analysed the capacity of CD4+ T cells from infected mice to produce IL-3 following stimulation with ConA for 24-72 h. In contrast to the position with
HIV-related neuropsychological impairment and immunodeficiency. CD8+ lymphocytes and neopterin are related to HIV-encephalopathy.: Scand J Psychol. 1994 Sep;35(3):230-9. Unique Identifier : AIDSLINE MED/95025722; Karlsen NR; Froland SS; Reinvang I; Department of Behavioural and Psychosomatic Medicine,; Rikshospitalet, National Hospital, Oslo, Norway.; The relationship between neuropsychological test performance and immunological parameters was studied in 52 HIV-positive patients within different stages of the infection. All subjects were neuropsychologically tested, the CD4+ and CD8+ lymphocyte count were measured in peripheral blood, and the concentration of neopt
Making drugs count. A new test could customize therapies-and boost profits [news]: Sci Am. 1994 Oct;271(4):132. Unique Identifier : AIDSLINE MED/95025799; Rennie J
Again, army shuns AIDS peer review [news]: Science. 1994 Oct 14;266(5183):207. Unique Identifier : AIDSLINE MED/95025901
New blood charges in Paris [news]: Science. 1994 Oct 14;266(5183):222. Unique Identifier : AIDSLINE MED/95025910; Holden C
Beefing up HIV antibodies [news]: Science. 1994 Oct 21;266(5184):366-7. Unique Identifier : AIDSLINE MED/95025931
WHO favors HIV vaccine tests [news]: Science. 1994 Oct 28;266(5185):547. Unique Identifier : AIDSLINE MED/95025957
An AIDS-like condition induced in baboons by HIV-2.: Science. 1994 Oct 28;266(5185):642-6. Unique Identifier : AIDSLINE MED/95025975; Barnett SW; Murthy KK; Herndier BG; Levy JA; Department of Medicine, School of Medicine, University of; California, San Francisco 94143.; Six baboons (Papio cynocephalus) were intravenously inoculated with the human immunodeficiency virus-type 2 (HIV-2) strain HIV-2UC2. All seroconverted within 6 weeks after inoculation; five animals became persistently infected. Four developed lymphadenopathy, and three of the animals had CD4+ T cell loss within 18 to
Nontropical pyomyositis in adults.: Semin Arthritis Rheum. 1994 Jun;23(6):396-405. Unique Identifier : AIDSLINE MED/95025983; Gomez-Reino JJ; Aznar JJ; Pablos JL; Diaz-Gonzalez F; Laffon A; Unidad de Reumatologia, Hospital Doce de Octubre, Madrid, Spain.; Pyomyositis (PMS) is a primary infection of striated muscle. Recent scanty reports suggest that non-tropical PMS may differ from classical tropical PMS. To address this question, 12 cases of nontropical PMS seen at two hospitals between 1976 and 1992 were reviewed and an English-literature search of similar cases was
A new disease [editorial]: Semin Roentgenol. 1994 Jul;29(3):227. Unique Identifier : AIDSLINE MED/95026058; Miller WT
Epidemiology and clinical manifestations of human immunodeficiency virus infection.: Semin Roentgenol. 1994 Jul;29(3):230-41. Unique Identifier : AIDSLINE MED/95026060; Frank I; Fishman N; Department of Medicine, University of Pennsylvania, Philadelphia; 19104-6073.
Pulmonary manifestations of acquired immunodeficiency syndrome.: Semin Roentgenol. 1994 Jul;29(3):242-74. Unique Identifier : AIDSLINE MED/95026061; Kuhlman JE; Department of Radiology, Johns Hopkins Outpatient Center,; Baltimore, MD 21287.
Gastrointestinal complications of human immunodeficiency virus (HIV) infection.: Semin Roentgenol. 1994 Jul;29(3):275-87. Unique Identifier : AIDSLINE MED/95026062; Feczko PJ; Department of Diagnostic Radiology, William Beaumont Hospital,; Royal Oak, MI 48073.
Neuroradiological manifestations of acquired immunodeficiency syndrome.: Semin Roentgenol. 1994 Jul;29(3):288-302. Unique Identifier : AIDSLINE MED/95026063; Lexa FJ; Department of Radiology, Hospital of the University of; Pennsylvania, Philadelphia 19104.
Imaging features of human immunodeficiency virus infection in infants and children.: Semin Roentgenol. 1994 Jul;29(3):303-14. Unique Identifier : AIDSLINE MED/95026064; Harty MP; Markowitz RI; Rutstein RM; Hunter JV; Department of Radiology, Children's Hospital of Philadelphia, PA; 19104.
[The prevention of AIDS in drug addicts superceded by the war on drugs, or what can happen when models to decrease the danger are not used]: Servir. 1994 Jul-Aug;42(4):219-25. Unique Identifier : AIDSLINE MED/95026070; Springer E
Living a responsible life: the impact of AIDS on the social identity of intravenous drug users.: Soc Sci Med. 1994 Aug;39(3):391-400. Unique Identifier : AIDSLINE MED/95026125; Hassin J; Department of Anthropology, University of Arizona, Tucson 85721.; The dominant image of an intravenous (i.v.) drug user in U.S. society is that of the unbridled dope fiend . It is common in treatment literature to refer to users as diseased and pathologically unable to control their lives. Female i.v. drug users, as the bearers of children, even more than males, are faced with the
[Occupational transmission of HIV/AIDS in health personnel and its risks]: Rozhl Chir. 1994 Jul;73(5):209. Unique Identifier : AIDSLINE MED/95026307; Walter G
[Can we consider fibrinogen a marker of human immunodeficiency virus infection progression? (letter)]: Sangre (Barc). 1994 Jun;39(3):226-7. Unique Identifier : AIDSLINE MED/95026335; Diez-Manglano J; Callau Barrio MP; Franco Alcalde L
[The acquired immunodeficiency syndrome and the occupational aspects of medicine]: Ter Arkh. 1994;66(6):81-5. Unique Identifier : AIDSLINE MED/95026678; Gavura VV
HIV/AIDS testing, reporting and practice limitations as required by Texas.: Tex Dent J. 1994 Apr;111(4):43-4. Unique Identifier : AIDSLINE MED/95026696; Hanna MJ
[Clinical aspects and therapy of Herpes simplex and Varicella-Zoster virus infections in practice]: Ther Umsch. 1994 Aug;51(8):538-44. Unique Identifier : AIDSLINE MED/95026707; Nadal D; Vogt M; Abteilung Immunologie/Hamatologie, Universitats-Kinderklinik; Zurich.; Primary infections with herpes simplex virus are usually localized, whereas those with varicella-zoster virus always disseminate. Both viruses persist within the host and may cause recurrent infections. Newborns and immunocompromised individuals have a risk for severe disease. Acycl
[HIV infection--current possibilities in antiviral therapy]: Ther Umsch. 1994 Aug;51(8):545-50. Unique Identifier : AIDSLINE MED/95026708; Hirschel B; Division des maladies infectieuses, Hopital cantonal; universitaire, Geneve.; Three drugs are currently available to treat HIV infection: zidovudine, didanosine, and zalcitabine. They resemble the natural nucleosides and inhibit retrotranscriptase, an enzyme which transforms HIV s genomic RNA into DNA. Indications for treatment are symptomatic HIV infection and, in asymptomatic patients, modera
[Cytomegaloviruses--clinical aspects and therapy]: Ther Umsch. 1994 Aug;51(8):551-7. Unique Identifier : AIDSLINE MED/95026709; Hamprecht K; Jahn G; Abteilung fur Medizinische Virologie und Epidemiologie der; Viruserkrankungen, Hygieneinstitut der Universitat Tubingen.; Human cytomegalovirus (HCMV) is an important pathogen for the fetus, recipients of solid organ transplants, bone marrow allograft patients, individuals infected with human immunodeficiency virus and other immunosuppressed patients. The clinical features of congenital cytomegaloviru
Does analysis of bronchoalveolar lavage fluid provide a tool to monitor disease progression or to predict survival in patients with HIV-1 infection? [editorial] [see comments]: Thorax. 1994 Sep;49(9):848-51. Unique Identifier : AIDSLINE MED/95026716; Agostini C; Semenzato G
Pneumocystis pneumonia in HIV antibody positive patients [letter; comment]: Thorax. 1994 Sep;49(9):940. Unique Identifier : AIDSLINE MED/95026739; Rodriguez-Roisin R; Barbera JA; Roca J
[Infections of the upper gastrointestinal tract--more than Helicobacter pylori?]: Tidsskr Nor Laegeforen. 1994 Sep 10;114(21):2498-500. Unique Identifier : AIDSLINE MED/95026751; Nysaeter G; Medisinsk avdeling, Fylkessjukehuset pa Stord.; Helicobacter pylori infection is a problem frequently handled by the gastroenterologist, but many other infections may cause symptoms and pathological findings which is of great significance for the endoscopist to recognize. Candida infection is the most common infection in the oesophagus. It may signal an underlying
[What advice should we give to prevent HIV infection when travelling abroad? (letter)]: Tidsskr Nor Laegeforen. 1994 Sep 10;114(21):2532-3. Unique Identifier : AIDSLINE MED/95026756; Thorvaldsen J; Moi H; Muniz HP
Vitamin E supplementation at various levels alters cytokine production by thymocytes during retrovirus infection causing murine AIDS.: Thymus. 1994;22(3):153-65. Unique Identifier : AIDSLINE MED/95026956; Wang Y; Watson RR; Department of Family and Community Medicine, University of; Arizona, Tucson.; Female C57BL/6 mice were infected with LP-BM5 retrovirus, causing murine AIDS which is functionally similar to human AIDS. Retrovirus infection targets the thymus producing altered T-cell differentiation via the dysregulation of thymocyte cytokine production. Therefore the effects of dietary vitamin E at various level
Epidemiologic background and long-term course of disease in human immunodeficiency virus type 1-infected blood donors identified before routine laboratory screening. Transfusion Safety Study Group.: Transfusion. 1994 Oct;34(10):858-64. Unique Identifier : AIDSLINE MED/95026970; Busch MP; Operskalski EA; Mosley JW; Stevens CE; Schiff ER; Kleinman SH; Lee H; Lee M; Harris M; Irwin Memorial Blood Center, University of California, San; Francisco.; BACKGROUND: The long-term course of human immunodeficiency virus type 1 (HIV-1)-related disease among seropositive blood donors has not been described. The enrollment and epidemiologic background of HIV-1-infected donors in the Transfusion Safety Study and their immunologic and clinical progression are described. STUD
The effectiveness of the confidential unit exclusion option [see comments]: Transfusion. 1994 Oct;34(10):865-9. Unique Identifier : AIDSLINE MED/95026971; Petersen LR; Lackritz E; Lewis WF; Smith DS; Herrera G; Raimondi V; Aberle-Grasse J; Dodd RY; Division of HIV/AIDS, National Center for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, Georgia.; BACKGROUND: The confidential unit exclusion (CUE) option is intended to reduce human immunodeficiency virus (HIV) transmission by excluding donors newly infected with HIV who have not yet developed HIV antibody (window-period donors); however, its efficacy in excluding window-period donors has not been evaluated. STUD
Demographic characteristics and prevalence of serologic markers among donors who use the confidential unit exclusion process: the Retrovirus Epidemiology Donor Study.: Transfusion. 1994 Oct;34(10):870-6. Unique Identifier : AIDSLINE MED/95026972; Korelitz JJ; Williams AE; Busch MP; Zuck TF; Ownby HE; Matijas LJ; Wright DJ; Westat, Inc., Rockville, Maryland.; BACKGROUND: Most blood centers utilize a confidential unit exclusion (CUE) process, intended to reduce the risk of transfusion-associated infectious diseases by allowing high-risk donors confidentially to exclude their blood from use for transfusion. The effectiveness of this method remains controversial. STUDY DESIGN
Results of 1-year screening of donors in The Netherlands for human T-lymphotropic virus (HTLV) type I: significance of Western blot patterns for confirmation of HTLV infection.: Transfusion. 1994 Oct;34(10):877-80. Unique Identifier : AIDSLINE MED/95026973; Zaaijer HL; Cuypers HT; Dudok de Wit C; Lelie PN; Central Laboratory of the Netherlands, Red Cross Blood; Transfusion Service.; BACKGROUND: Between January 1993 and January 1994, Dutch blood banks screened approximately 674,000 volunteer donors for the presence of antibodies to human T-lymphotropic virus type I (HTLV-I). STUDY DESIGN AND METHODS: Confirmatory testing was performed on samples from 870 different anti-HTLV-I-reactive donors (0.13
Yersinia enterocolitica septicemia in autologous blood transfusion.: Transfusion. 1994 Oct;34(10):907-9. Unique Identifier : AIDSLINE MED/95026979; Haditsch M; Binder L; Gabriel C; Muller-Uri P; Watschinger R; Mittermayer H; Institute for Medical Mikrobiology and Hygiene, Elizabeth; Hospital, Linz, Austria.; BACKGROUND: Increasingly, autologous blood transfusions are used in elective surgical procedures to avoid the risk of infection due to allogeneic blood transfusion. CASE REPORT: A 64-year-old patient had to undergo the implantation of a total right hip endoprosthesis. During the transfusion of 1 unit of autologous pac
Impact of de novo membranous glomerulonephritis on the clinical course after kidney transplantation.: Transplantation. 1994 Sep 27;58(6):650-4. Unique Identifier : AIDSLINE MED/95026997; Schwarz A; Krause PH; Offermann G; Keller F; Department of Nephrology, Klinikum Steglitz, Free University of; Berlin, Germany.; Besides rejection-induced transplant glomerulopathy de novo membranous glomerulonephritis (MGN) is the most frequent cause of nephrotic syndrome after renal transplantation. We evaluated 1029 renal transplantations (271 without and 758 with cyclosporine treatment), performed on 848 patients between 1970 and 1992, whic
Effects of systemic administration of rIL-10 in an in vivo model of alloreactivity.: Transplantation. 1994 Oct 27;58(8):972-4. Unique Identifier : AIDSLINE MED/95027071; Delvaux A; Donckier V; Bruyns C; Florquin S; Gerard C; Amraoui Z; Abramowicz D; Goldman M; Velu T; Department of Medical Genetics, Institut de Recherche; Interdisciplinaire en Biologie Humaine et Nucleaire, Universite; Libre de Bruxelles, Belgium.
Optimal immunosuppressive clinical regimen in liver transplantation.: Transplant Proc. 1994 Oct;26(5):2676-8. Unique Identifier : AIDSLINE MED/95027170; Farges O; Samuel D; Bismuth H; Hepato-biliary Surgery and Liver Transplantation Center, Paul; Brousse Hospital, Villejuif, France.
Effect of cyclosporine on different porcine lymphoid tissues.: Transplant Proc. 1994 Oct;26(5):2865. Unique Identifier : AIDSLINE MED/95027239; Mellert J; Saalmuller A; Hessmer I; Hopt UT; Department of Surgery, University of Tubingen, Germany.
Intake of a cohort study of urban factory workers in northwest Tanzania. Risk factors for HIV-1 infection.: Trop Geogr Med. 1994;46(3):157-62. Unique Identifier : AIDSLINE MED/95027349; Barongo LR; Borgdorff MW; Newell JN; Senkoro KP; Klokke AH; Changalucha J; Deville W; Velema JP; Coutinho RA; Gabone RM; National Institute for Medical Research, Mwanza, Tanzania.; A cohort study has been started of urban factory workers and their spouses in Tanzania , in order to 1) identify risk factors for HIV-1 seroconversion, and 2) document changes over time in risk behaviour, in particular condom use and partner change, and determine whether these are
Incidence and clinical manifestations of HIV-1 infection in multitransfused thalassaemic Indian children.: Trop Geogr Med. 1994;46(3):163-6. Unique Identifier : AIDSLINE MED/95027350; Kumar RM; Uduman S; Hamo IM; Morrison J; Khaurana AK; Department of Obstetrics and Gynaecology, Faculty of Medicine and; Health Sciences, UAE University, Al-Ain.; Four hundred and six multitransfused thalassaemic children attending the paediatric clinic in Manipur, India , were screened for HIV antibodies. There were 46 (8.9%) ELISA antibody-positive children and the diagnosis was reaffirmed by Western blot assay. The immunologic status of the
[Extrapulmonary tuberculosis in Denmark. A review of the incidence, localization and therapy]: Ugeskr Laeger. 1994 Sep 12;156(37):5266-8. Unique Identifier : AIDSLINE MED/95027404; Kok-Jensen A; Viskum K; Lungemedicinsk afdeling P, Bispebjerg Hospital, Kobenhavn.; In Denmark , just under 20% of tuberculosis (TB) cases amongst Danes and 25-30% of cases amongst people of foreign nationalities are made up of isolated extrapulmonary (EP) TB. The incidence among Danes is falling, whereas an increas
[The philosophy of hospices. The St Luke's Hospice establishment in Hellerup, evaluation of the first year]: Ugeskr Laeger. 1994 Sep 12;156(37):5304-7. Unique Identifier : AIDSLINE MED/95027415; Moe C; Sankt Lukas Stiftelsens Hospice, Hellerup.; The purpose of the article is to present collected data from the first year following the establishment of Sankt Lukas Hospice in Hellerup in Denmark and to expound on the philosophy of hospices. Eighty-five patients were admitted t
[Sequelae of imported tropical diseases in Germany]: Versicherungsmedizin. 1994 Aug 1;46(4):135-7. Unique Identifier : AIDSLINE MED/95027583; Nothdurft HD; Loscher T; Abteilung fur Infektions- und Tropenmedizin der Univ., Munchen.; 20-50% of all travellers to tropical and subtropical countries experience health problems during or after travel. Mainly respiratory tract infections or gastrointestinal disorders are predominant. As specific disorders imported from the tropics traveller s diarrhoea is prevailing, however amebic and helminthic infecti
Bovine NK and LAK susceptibility is independent of class I expression on B lymphoblastoid variants.: Vet Immunol Immunopathol. 1994 Jun;41(3-4):189-200. Unique Identifier : AIDSLINE MED/95027664; Li W; Splitter GA; Department of Animal Health and Biomedical Sciences, University; of Wisconsin-Madison 53706.; Numerous tumors express low or no class I molecules, resulting in their avoidance of recognition and destruction by different effector cells of the immune system. Using a parent and two MHC class I mutant cell lines, we have tested the role of MHC class I molecules in natural killer (NK) cells, lymphokine activated ki
Cytotoxic T cell responses in lambs experimentally infected with Border disease virus.: Vet Immunol Immunopathol. 1994 Jun;41(3-4):201-9. Unique Identifier : AIDSLINE MED/95027665; Woldehiwet Z; Hussin AA; University of Liverpool, Department of Veterinary Pathology,; Leahurst, Neston, Wirral, UK.; Mononuclear cells cytotoxic to a noncytopathic strain of Border disease virus (BDV) but not to uninfected cells were detected in the peripheral blood of experimentally infected lambs, 10 days after experimental infection, reaching peak levels of cytotoxicity 15 days post-inoculation. The specificity of the cytotoxic a
Spectral analysis and tryptic susceptibility as probes of HIV-1 capsid protein structure.: Virology. 1994 Nov 1;204(2):515-25. Unique Identifier : AIDSLINE MED/95027680; Ehrlich LS; Agresta BE; Gelfand CA; Jentoft J; Carter CA; Department of Microbiology, S.U.N.Y. at Stony Brook 11794.; The structures of HIV-1 capsid protein (CA, p24) isolated from mature virions and CA protein autoprocessed from a recombinant Gag-Pol precursor expressed in Escherichia coli were compared using circular dichroic (CD) spectral analysis. The spectra obtained for the intact recombinant and viral proteins were indistingui
Interferon-gamma decreases cell surface expression of galactosyl ceramide, the receptor for HIV-1 GP120 on human colonic epithelial cells [published erratum appears in Virology 1995 Feb 20;207(1):343]: Virology. 1994 Nov 1;204(2):550-7. Unique Identifier : AIDSLINE MED/95027683; Yahi N; Spitalnik SL; Stefano KA; De Micco P; Gonzalez-Scarano F; Fantini J; CNRS URA 1455, Faculte de Medecine Nord, Marseille, France.; HT-29-A7, a CD4-negative clonal derivative of the human colonic adenocarcinoma cell line HT-29, is particularly sensitive to infection by several isolates of HIV-1 and, correspondingly, expresses high amounts of galactosylceramide (galactocerebroside, GalCer). GalCer is a neutral glycolipid which binds to the HIV-1 en
Antibodies to the HIV-1 V3 loop in serum from infected persons contribute a major proportion of immune effector functions including complement activation, antibody binding, and neutralization.: Virology. 1994 Nov 1;204(2):609-15. Unique Identifier : AIDSLINE MED/95027690; Spear GT; Takefman DM; Sharpe S; Ghassemi M; Zolla-Pazner S; Department of Immunology/Microbiology, Rush Medical School,; Chicago, Illinois 60612.; Previous studies have shown that the V3 region of the HIV envelope is both critical to viral functions and immunogenic. However, the relative contribution of anti-V3 antibodies in the sera of infected individuals in mediating immune effector functions directed at whole intact virus and infected cells has not been dete
Transactivation of methylated HIV-LTR by a frog virus 3 protein.: Virology. 1994 Nov 1;204(2):651-5. Unique Identifier : AIDSLINE MED/95027695; Spangler CM; Essani K; Department of Biological Sciences, College of Arts and Sciences,; Western Michigan University, Kalamazoo 49008.; DNA methylation has been implicated in the suppression of transcription of a large spectrum of eukaryotic genes. Frog virus 3 (FV3) contains genomic DNA that is the most extensively methylated of all known animal viruses. However, FV3 gene expression is tightly regulated in a sequential fashion in infected cells. Ther
Construction and characterization of infectious human T-cell leukemia virus type 1 molecular clones.: Virology. 1994 Nov 1;204(2):656-64. Unique Identifier : AIDSLINE MED/95027696; Kimata JT; Wong FH; Wang JJ; Ratner L; Department of Medicine, Washington University School of Medicine,; St. Louis, Missouri 63110.; Molecular clones of human T-cell leukemia virus type 1 (HTLV-1) have been constructed and stably propagated in plasmids in Escherichia coli. Expression of Tax could be demonstrated from these clones in fibroblast and epithelial cell lines. HOS cells stably transfected with HTLV-1 clone ACH produced all three classes o
Genome organization of a biologically active molecular clone of the lymphoproliferative disease virus of turkeys.: Virology. 1994 Nov 1;204(2):680-91. Unique Identifier : AIDSLINE GENBANK/U09568; Sarid R; Chajut A; Gak E; Kim Y; Hixson CV; Oroszlan S; Tronick SR; Gazit A; Yaniv A; Department of Human Microbiology, Sackler School of Medicine,; Tel-Aviv University, Israel.; The lymphoproliferative disease retrovirus (LPDV) induces an acute, horizontally transmitted disease of turkeys that is often fatal. Although LPDV cannot be grown in cultured cells, it was possible to isolate molecular clones of biologically active integrated proviral genomes from spleens of infected turkeys. Based up
Subcellular redistribution of HTLV-1 Tax protein by NF-kappa B/Rel transcription factors.: Virology. 1994 Nov 1;204(2):706-16. Unique Identifier : AIDSLINE MED/95027701; Pepin N; Roulston A; Lacoste J; Lin R; Hiscott J; Terry Fox Molecular Oncology Group, Lady Davis Institute for; Medical Research, Jewish General Hospital, Montreal, Quebec,; Canada.; The viral oncogene Tax derived from human T cell leukemia virus type I (HTLV-I) is a positive transcriptional activator of HTLV-1 gene expression. Tax is also able to indirectly stimulate transcription of several growth regulatory genes by an indirect mechanism via association with host transcription factors. One of t
Analysis of the vif gene of feline immunodeficiency virus.: Virology. 1994 Nov 1;204(2):860-7. Unique Identifier : AIDSLINE MED/95027724; Shacklett BL; Luciw PA; Department of Medical Pathology, University of California, Davis; 95616.; We have examined FIV vif function in the context of molecular clone pF34 (GenBank Accession No. M25729). Rabbit antisera directed against the translation product of the vif gene identified a 29-kDa protein in tissue culture cells infected with FIV-pF34; this protein was not present in cultures of uninfected cells. Thu
[The dependence of the biological activity of metal complexes on the structural stability of the initial DNA]: Voen Med Zh. 1994 Jun;(6):38-40, 80. Unique Identifier : AIDSLINE MED/95027816; Vainberg IuP; Nosik DN; Kaplina EN; The authors have formulated the basic principles of the creation of metallo-constructions with DNA which possess biological activity. Thus, the interaction of metal and DNA during formation of metallo-construction must not destabilize the structure of initial DNA. The studies conducted by the authors prove the hypothe
Investigating pediatric HIV research ethics in the field.: West J Nurs Res. 1994 Aug;16(4):404-13. Unique Identifier : AIDSLINE MED/95027894; Twomey JG Jr; College of Nursing, University of Rhode Island, Kingston.; Physician and nurse researchers, Institutional Review Board members, and parents of children with HIV were asked, during interviews, to describe their views on the ethical issues involved in the conduct of clinical drug research that uses as subjects children who are seropositive for HIV. Twenty-eight interviews at fo
The control of tuberculosis in the Caribbean.: West Indian Med J. 1994 Jun;43(2):48-51. Unique Identifier : AIDSLINE MED/95027905; Werker D; Blount S; White FM; Department of Health Care & Epidemiology, University of British; Columbia, Vancouver, Canada.; A survey of the Ministries of Health in the English-speaking Caribbean countries was conducted with the purpose of collecting information about current capacity in the prevention and control of tuberculosis. A response rate of 78.9% was achieved. The results of this survey indicate that tuberculosis control programmes
Continuing medical education about AIDS--a needs assessment.: West J Med. 1994 Jul;161(1):34-8. Unique Identifier : AIDSLINE MED/95027912; Lewis CE; Carlisle D; Center for Health Promotion and Disease Prevention, University of; California, School of Medicine, Los Angeles 90024-1772.; The incidence of the acquired immunodeficiency syndrome (AIDS) among Latinos and African Americans nationally and in Los Angeles has risen substantially. No data exist to indicate which physicians (or groups of physicians) provide care to these groups, however. To better plan AIDS educational programs, efforts were ma
The acquired immunodeficiency syndrome in women.: West J Med. 1994 Aug;161(2):161-3. Unique Identifier : AIDSLINE MED/95027946; MacKay HT; Kamb ML
[Autoimmune phenomena in the course of chronic infections]: Wiad Lek. 1994 Mar;47(5-6):193-7. Unique Identifier : AIDSLINE MED/95027969; Radkowski M; Laskus T; Zakladu Immunopatologii, Instytutu Chorob Zakaznych i; Pasozytniczych Ak. Med. w Warszawie.; Probable mechanisms responsible for the development of autoimmune disorders in the course of acute and chronic infectious diseases are discussed in the paper. The most common infections ongoing with significant symptoms of immune reactions directed against self antigens are also presented.
[Clinical aspects of pulmonary tuberculosis]: Wien Med Wochenschr. 1994;144(8-9):146-53. Unique Identifier : AIDSLINE MED/95028009; Wolf K; Internen Lungenabteilung, Pulmologischen Zentrums der Stadt Wien.; The low incidence of pulmonary tuberculosis has led to a decrease of doctors expertise in this field. This review deals with clinical aspects of the disease. This article does not refer to the problem of simultaneous infection with tuberculosis and HIV. Pathogenesis, symptoms and diagnosis are discussed. A classificat
[Current status of tuberculosis in Vienna]: Wien Med Wochenschr. 1994;144(8-9):153-5. Unique Identifier : AIDSLINE MED/95028010; Wallner GW; Zehetner E; Junker E; Gesundheitsamt der Stadt Wien.; The increasing number of HIV infected persons on the one hand, and a continuously increasing number of immigrants from countries with high incidence of active tuberculosis on the other hand have an influence on the incidence of tuberculosis in Vienna in general. Nevertheless people of Austrian origin have a decreasing
[Microbiological diagnosis of tuberculosis]: Wien Med Wochenschr. 1994;144(8-9):156-62. Unique Identifier : AIDSLINE MED/95028011; Allerberger F; Fille M; Streif W; Luef G; Schmutzhard E; Dierich MP; Institut fur Hygiene, Universitat Innsbruck.; The increased incidence of tuberculosis as well as the availability of new diagnostic testing methods clearly have various implications for the routine microbiology laboratory: samples must be sent to the microbiology lab for testing immediately after being taken and microscopically investigated the same day. In other
[Pulmonary manifestations of tuberculosis in childhood]: Wien Med Wochenschr. 1994;144(8-9):174-7. Unique Identifier : AIDSLINE MED/95028014; Hagel E; Internen Kinderabteilung, Wilhelminenspitals der Stadt Wien.; We mention the major pathogenous characteristics of a tuberculosis infection. Immunity to tuberculosis and tuberculin allergy are connected with each other but are not identical reactions of the organism. We describe the well-known complications in primary infections, namely the primary focus and the formation of lymp
[Infections with Mycobacterium tuberculosis and MOTT (Mycobacteria other than tuberculosis) in HIV infected and AIDS patients]: Wien Med Wochenschr. 1994;144(8-9):182-6. Unique Identifier : AIDSLINE MED/95028016; Armbruster C; Internen Abteilung, Pulmologischen Zentrums der Stadt Wien.; AIDS is characterized by a variety of opportunistic infections and malignant tumours. Tuberculosis occurs 500 times more often in HIV-infected patients than in patients with normal immunological function. In contrast to tuberculosis, which is diagnosed before the 1st AIDS defining disease, MOTT-infections are complica
[Comparison of four different methods for respiratory determination of the anaerobic threshold in normal people, and heart- and lung patients]: Z Kardiol. 1994;83 Suppl 3:37-42. Unique Identifier : AIDSLINE MED/95028082; Gitt AK; Winter UJ; Fritsch J; Pothoff G; Sedlak M; Ehmanns S; Ostmann H; Hilger HH; Klinik III fur Innere Medizin, Kardiologie, Universitat zu; Koln.; We analyzed 128 cardiopulmonary exercise tests (CPX), performed in normal subjects (n = 31), in patients with coronary artery disease (n = 41), with chronic heart failure before (n = 14) and after (n = 14) application of oral PDE-inhibitors and in patients with HIV-infection on a bicycle-ergometer in semi-supine posit
Mandatory testing for HIV: part of the solution--or part of the problem? [editorial]: P N G Med J. 1993 Dec;36(4):281-4. Unique Identifier : AIDSLINE MED/95028170; O'Leary MJ
Characteristics of users of syringe vending machines in Berlin.: Soz Praventivmed. 1994;39(4):209-16. Unique Identifier : AIDSLINE MED/95028185; Stark K; Leicht A; Muller R; Landesinstitut fur Tropenmedizin, Berlin.; Vending machines providing sterile injection equipment are part of the AIDS prevention measures for injecting drug users (IDU) in Berlin. A study was carried out to assess characteristics (history of iv drug use, frequency of use of the machines, contact with counselling units for IDU, attitudes towards the machines,
[A system of simulation models of the epidemic process based on a socioecological concept]: Zh Mikrobiol Epidemiol Immunobiol. 1994 May-Jun;(3):44-9. Unique Identifier : AIDSLINE MED/95028308; Zakhar'iashcheva OV; Krut'kov VN; Cherkasskii BL; In this paper different methods of modeling the epidemic process for different types of infectious diseases are discussed. We propose a concept of modeling for an essentially nonhomogeneous human population, taking into account biological, ecological and social factors. The method of an epidemiological tree has been d
Early pathological changes in progressive multifocal leukoencephalopathy: a report of two asymptomatic cases occurring prior to the AIDS epidemic.: Acta Neuropathol (Berl). 1994;88(1):93-105. Unique Identifier : AIDSLINE MED/95028435; Astrom KE; Stoner GL; National Institutes of Health, Bethesda, MD 20892.; Serial sections of formalin-fixed, paraffin-embedded blocks from two asymptomatic, non-AIDS cases of progressive multifocal leukoencephalopathy (PML) were stained with a double-label immunocytochemical method for detection of glial fibrillary acidic protein and JC virus (JCV) capsid proteins and with luxol fast blue/h
Acute thrombocytopenic purpura associated with primary Epstein-Barr virus infection.: Acta Paediatr Jpn. 1994 Aug;36(4):423-6. Unique Identifier : AIDSLINE MED/95028469; Kanegane H; Miyawaki T; Iwai K; Tsuji T; Taniguchi N; Department of Pediatrics, School of Medicine, Kanazawa; University, Ishikawa, Japan.; Acute idiopathic thrombocytopenic purpura (ITP) often appears to be related to the sensitization by some viral infections. However, the causative viral agents are not identified in most cases. Although the primary infection with Epstein-Barr virus (EBV) occurs during early childhood in
Influence of refrain from breast feeding on acquisition of natural cytomegalovirus immunity in an endemic area of HTLV-I.: Acta Paediatr Jpn. 1994 Aug;36(4):457-9. Unique Identifier : AIDSLINE MED/95028478; Fujioka K; Ueda K; Miyazaki C; Okada K; Kusuhara K; Hidaka Y; Tokugawa K; Kashiwagi S; Division of Pediatrics, Karatsu Red Cross Hospital, Saga, Japan.
Caring for the family with acquired immunodeficiency syndrome (AIDS) [editorial]: Acta Paediatr Sin. 1994 Sep-Oct;35(5):353-5. Unique Identifier : AIDSLINE MED/95028480; Cho CT; Belmont JM
Sean's story: the death of a young boy by AIDS.: Acta Paediatr Sin. 1994 Sep-Oct;35(5):373-6. Unique Identifier : AIDSLINE MED/95028482; Voorhees BB
Severe opportunistic infections in AIDS patients with late-stage disease.: J Am Board Fam Pract. 1994 Jul-Aug;7(4):288-91. Unique Identifier : AIDSLINE MED/95028565; Lifson AR; Olson R; Roberts SG; Poscher ME; Drew WL; Conant MA; Department of Epidemiology and Biostatistics, School of Medicine,; University of California, San Francisco.; BACKGROUND: Clinicians caring for patients who have acquired immunodeficiency syndrome (AIDS) need to be aware of the wide variety of infectious diseases that can occur. Although Pneumocystis carinii pneumonia (PCP) is the most common AIDS-defining infection, other opportunistic infections associated with advanced imm
Preventive health care and screening of Latin American immigrants in the United States.: J Am Board Fam Pract. 1994 Jul-Aug;7(4):310-23. Unique Identifier : AIDSLINE MED/95028568; Weissman AM; Brown University Program in Family Medicine, Memorial Hospital of; Rhode Island, Pawtucket 02860.; BACKGROUND: The Central and South American immigrant population in the United States is large and growing. A review of the preventive health care needs of this population has not previously been done but would be helpful to clinicians caring for immigrants in this country. METHODS: Usi
Brain biopsy in AIDS. Diagnostic value and consequence.: Acta Neurochir (Wien). 1994;127(1-2):99-102. Unique Identifier : AIDSLINE MED/95028663; Nielsen CJ; Gjerris F; Pedersen H; Jensen FK; Wagn P; University Clinic of Neurosurgery, Rigshospitalet, Copenhagen,; Denmark.; Nineteen male patients with AIDS were investigated by biopsy of brain lesions. Six patients had progressive multiple leucoencephalopathy and no specific treatment was given. Toxoplasmosis (two patients), bacterial abscesses (two cases), viral encephalitis (two patients) and only gliosis (two cases) accounted for almos
Dermatologic and systemic manifestations of syphilis.: Am Fam Physician. 1994 Oct;50(5):1013-20. Unique Identifier : AIDSLINE MED/95028891; Goens JL; Janniger CK; De Wolf K; Free University of Brussels, Belgium.; The incidence of syphilis is increasing, predominantly among urban heterosexuals. Early recognition is important in preventing progression of the disease and transmission of Treponema pallidum to the fetus. Untreated primary syphilis is characterized by intervals of active disease punctuated by periods of latency. Not
Approval of drugs for HIV infection [news]: Am Fam Physician. 1994 Oct;50(5):1138. Unique Identifier : AIDSLINE MED/95028898
Mechanical compression of the left coronary artery resulting from periannular extension of aortic endocarditis: diagnosis by transesophageal echocardiography.: Am Heart J. 1994 Oct;128(4):823-7. Unique Identifier : AIDSLINE MED/95028949; Vilacosta I; Camino A; Sarriia C; Castillo JA; Rollan MJ; Roman JA; Nieto S; Sanchez-Harguindey L; Department of Cardiology, Hospital Universitario de San Carlos,; Madrid, Spain.
Stavudine (d4T) for HIV [news]: Am Pharm. 1994 Aug;NS34(8):9. Unique Identifier : AIDSLINE MED/95029000
Variation in the enteric distribution of cryptosporidia in acquired immunodeficiency syndrome.: Am J Clin Pathol. 1994 Oct;102(4):420-5. Unique Identifier : AIDSLINE MED/95029097; Clayton F; Heller T; Kotler DP; Department of Pathology, Salt Lake Veterans Affairs Hospital, UT; 84148.; Clinical observation suggests that the natural history of intestinal cryptosporidiosis in patients with acquired immunodeficiency syndrome varies greatly. The relation between clinical, small-bowel functional, and nutritional status and the intestinal distribution of the organism was studied in 41 patients who had acq
Pulmonary malacoplakia associated with Rhodococcus equi infection in a patient with acquired immunodeficiency syndrome.: Am J Clin Pathol. 1994 Oct;102(4):459-63. Unique Identifier : AIDSLINE MED/95029104; de Peralta-Venturina MN; Clubb FJ; Kielhofner MA; Department of Pathology, University of Texas M.D. Anderson Cancer; Center, Houston.; Pulmonary malacoplakia associated with Rhodococcus equi, an opportunistic Gram-positive coccobacillus, is unusual. Although this patient is the ninth reported to have pulmonary malacoplakia, he is only the third patient with the acquired immunodeficiency syndrome who has been reported to have pulmonary malacoplakia as
Plasma cell myeloma in patients who are HIV-positive.: Am J Clin Pathol. 1994 Nov;102(5):633-9. Unique Identifier : AIDSLINE MED/95029137; Kumar S; Kumar D; Schnadig VJ; Selvanayagam P; Slaughter DP; Department of Pathology, University of Texas Medical Branch,; Galveston.; This report describes the occurrence of plasma cell neoplasia in three young HIV-positive males. Two patients presented with massive ascites. On cytologic examination of the fluid, many immature plasma cells were noted. Genotyping of fluid demonstrated clonal rearrangement of immunoglobulin heavy and kappa light chain
Mucormycosis esophagitis in a patient with the acquired immunodeficiency syndrome.: Am J Gastroenterol. 1994 Oct;89(10):1900-2. Unique Identifier : AIDSLINE MED/95029209; Margolis PS; Epstein A; Department of Medicine, Roger Williams Medical Center, Brown; University, Rhode Island Hospital, Providence.
Re: Etiology of human immunodeficiency virus-associated idiopathic esophageal ulcer [letter; comment]: Am J Gastroenterol. 1994 Oct;89(10):1913-4. Unique Identifier : AIDSLINE MED/95029216; Wilcox CM; Hewan-Lowe K
Prevalence of intestinal microsporidiosis in HIV-infected individuals referred for gastroenterological evaluation [see comments]: Am J Gastroenterol. 1994 Nov;89(11):1998-2002. Unique Identifier : AIDSLINE MED/95029239; Kotler DP; Orenstein JM; Department of Medicine, St. Luke's-Roosevelt Hospital Center,; Columbia University, New York.; OBJECTIVES: The reported prevalence of enteric pathogens, especially microsporidiosis , in HIV infection varies greatly. In this study, the prevalence rates for microsporidiosis and other enteric pathogens in HIV-infected individuals referred for gastrointestinal sympto
Esophageal motility in AIDS patients with symptomatic opportunistic infections of the esophagus.: Am J Gastroenterol. 1994 Nov;89(11):2003-5. Unique Identifier : AIDSLINE MED/95029240; Fried RL; Brandt LJ; Kauvar D; Simon D; Division of Gastroenterology, Montefiore Medical Center/Albert; Einstein College of Medicine, Bronx, New York.; OBJECTIVES: In patients with AIDS, esophageal symptoms are commonly due to opportunistic esophageal infection with Candida, cytomegalovirus ( CMV ), herpes simplex virus (HSV), and HIV. Despite apparently appropriate therapy ag
Shingles, allergies, family medical history, oral contraceptives, and other potential risk factors for systemic lupus erythematosus.: Am J Epidemiol. 1994 Oct 1;140(7):632-42. Unique Identifier : AIDSLINE MED/95029279; Strom BL; Reidenberg MM; West S; Snyder ES; Freundlich B; Stolley PD; Center for Clinical Epidemiology and Biostatistics, University of; Pennsylvania School of Medicine, Philadelphia 19104-6095.; The authors undertook a case-control study to explore the many factors that have been postulated to be related to the etiology of systemic lupus erythematosus. A total of 195 cases of systemic lupus diagnosed in the Philadelphia, Pennsylvania, metropolitan area between 1985 and 1987 were compared with 143 controls, fr
Determinants of HIV disease progression among homosexual men registered in the Tricontinental Seroconverter Study.: Am J Epidemiol. 1994 Oct 15;140(8):747-58. Unique Identifier : AIDSLINE MED/95029294; Veugelers PJ; Page KA; Tindall B; Schechter MT; Moss AR; Winkelstein WW Jr; Cooper DA; Craib KJ; Charlebois E; Coutinho RA; et al; Municipal Health Service, Department of Public Health, Amsterdam,; The Netherlands.; Data on 403 homosexual/bisexual men with documented dates of human immunodeficiency virus (HIV) seroconversion were merged. All subjects originated from cohort studies that started between 1982 and 1984 in Amsterdam, The Netherlands ; San Francisco, California; Sydney,
Serum vitamin B12 and transcobalamin levels in early HIV disease.: Am J Hematol. 1994 Nov;47(3):167-71. Unique Identifier : AIDSLINE MED/95029298; Rule SA; Hooker M; Costello C; Luck W; Hoffbrand AV; Department of Haematology, Westminster and Chelsea Hospital,; London, England.; A cohort of asymptomatic human immunodeficiency virus (HIV) seropositive patients was followed over a 2 1/2-year period, to establish changes in serum vitamin B12 (B12) concentrations. Serum B12, CD4 count, and clinical progression to acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) were measure
Gastrointestinal histoplasmosis presenting as hematochezia in human immunodeficiency virus-infected hemophilic patients.: Am J Hematol. 1994 Nov;47(3):229-31. Unique Identifier : AIDSLINE MED/95029309; Becherer PR; Sokol-Anderson M; Joist JH; Milligan T; Department of Internal Medicine, Saint Louis University Health; Sciences Center, Missouri.; Two hemophiliacs infected with human immunodeficiency virus (HIV) presented with hematochezia secondary to gastrointestinal involvement with Histoplasmosis capsulatum. In one patient who was already receiving fluconazole, the diagnosis was obscured. Both patients responded to amphotericin B followed by intraconazole,
Suppression of HTLV-1-induced human leukemia cell infiltration by zidovudine [letter]: Am J Hematol. 1994 Nov;47(3):246-7. Unique Identifier : AIDSLINE MED/95029318; Saito N; Takemori N; Hirai K; Onodera R; Watanabe S; Namiki M
Antineutrophil cytoplasmic autoantibodies in human immunodeficiency virus infection [letter]: Am J Kidney Dis. 1994 Oct;24(4):731. Unique Identifier : AIDSLINE MED/95029356; Sakkas L; Kistis C; Akritidis N
State regulations and the HIV-positive health care professional: a response to a problem that does not exist.: Am J Law Med. 1993;19(4):497-522. Unique Identifier : AIDSLINE MED/95029389; DiMaggio SL; An announcement in July 1990 concerning the possible transmission of the Human Immunodeficiency Virus from an HIV-positive health care professional to a patient launched a public outcry for patient protection from acquiring HIV from health care professionals. As a result of numerous debates, Congress issued a mandate
AIDS: confidentiality of HIV status--in re Doe.: Am J Law Med. 1993;19(4):547-8. Unique Identifier : AIDSLINE MED/95029391
Status of HIV vaccine development.: Am J Hosp Pharm. 1994 Jul 15;51(14):1816-8. Unique Identifier : AIDSLINE MED/95029439; Minor JR; Clinical Center Pharmacy, National Institutes of Health,; Bethesda, MD 20892.
Transmission of HIV in the home.: Am J Hosp Pharm. 1994 Jul 15;51(14):1818-9. Unique Identifier : AIDSLINE MED/95029440; DeChristoforo R; Clinical Center Pharmacy, National Institutes of Health,; Bethesda, MD 20892.
Epidemiology of oral candidiasis in HIV-infected patients: colonization, infection, treatment, and emergence of fluconazole resistance.: Am J Med. 1994 Oct;97(4):339-46. Unique Identifier : AIDSLINE MED/95029463; Sangeorzan JA; Bradley SF; He X; Zarins LT; Ridenour GL; Tiballi RN; Kauffman CA; Department of Internal Medicine, University of Michigan Medical; School, Ann Arbor.; PURPOSE: To study the epidemiology of oral candidiasis and the effect of treatment of thrush in human immunodeficiency virus (HIV)-infected patients. PATIENTS AND METHODS: We conducted a prospective observational study of 92 patients over 1 year, including a nonblinded, randomi
Factors associated with initiation of primary medical care for HIV-infected persons.: Am J Med. 1994 Oct;97(4):347-53. Unique Identifier : AIDSLINE MED/95029464; Samet JH; Retondo MJ; Freedberg KA; Stein MD; Heeren T; Libman H; Section of General Internal Medicine, Boston City Hospital,; Boston University School of Medicine, Massachusetts.; PURPOSE: To examine the degree of immune dysfunction of human immunodeficiency virus (HIV)-infected patients at the time of presentation and to identify factors associated with early and late initial primary medical care for HIV infection as measured by CD4+ lymphocyte count. PATIENTS AND METHODS: Two hundred fifty-on
An 11-month old boy with AIDS [news]: Am J Nurs. 1994 Oct;94(10):67. Unique Identifier : AIDSLINE MED/95029588
Polymerase chain reaction identification of human immunodeficiency virus-1 in preserved human sclera [letter]: Am J Ophthalmol. 1994 Oct 15;118(4):528-30. Unique Identifier : AIDSLINE MED/95029673; Seiff SR; Chang JS Jr; Hurt MH; Khayam-Bashi H
Psychopathology in male and female intravenous drug users with and without HIV infection.: Am J Psychiatry. 1994 Nov;151(11):1662-8. Unique Identifier : AIDSLINE MED/95030040; Lipsitz JD; Williams JB; Rabkin JG; Remien RH; Bradbury M; el Sadr W; Goetz R; Sorrell S; Gorman JM; HIV Center for Clinical and Behavioral Studies, New York State; Psychiatric Institute, New York.; OBJECTIVE: The authors report on results of systematic clinical assessment of psychopathology among HIV-positive and HIV-negative intravenous drug users. METHOD: As part of a multidisciplinary baseline assessment, 147 male (85 HIV-positive and 62 HIV-negative) and 76 female (39 HIV-positive and 37 HIV-negative) intrav
HIV infection among women in prison: an assessment of risk factors using a nonnominal methodology.: Am J Public Health. 1994 Oct;84(10):1637-40. Unique Identifier : AIDSLINE MED/95030068; Hankins CA; Gendron S; Handley MA; Richard C; Tung MT; O'Shaughnessy M; Centre for AIDS Studies, Montreal-Centre Regional Public Health; Team, Quebec, Canada.; The relative contributions of needle use practices and sexual behaviors to human immunodeficiency virus (HIV) antibody seropositivity among 394 women incarcerated in Quebec were determined by risk factor assessment and serology with a nonnominal methodology. HIV positivity was found in 6.9% (95% confidence interval [C
Autopsy rates among patients reported with AIDS [letter]: Am J Public Health. 1994 Oct;84(10):1695-6. Unique Identifier : AIDSLINE MED/95030088; Schable B; Chu SY
Immunodeficiency-associated malignant lymphoma. Three cases showing genotypic evidence of both T- and B-cell lineages.: Am J Surg Pathol. 1994 Nov;18(11):1092-101. Unique Identifier : AIDSLINE MED/95030116; Hollingsworth HC; Stetler-Stevenson M; Gagneten D; Kingma DW; Raffeld M; Jaffe ES; Laboratory of Pathology, National Cancer Institute, Bethesda, MD; 20892.; Dual rearrangement of both immunoglobulin and T-cell receptor (TCR) genes has been described in up to 30% of precursor lymphoid neoplasms, but this phenomenon occurs rarely in lymphomas with a mature phenotype. We describe three cases of immunodeficiency-associated lymphomas, two in patients with acquired immunodefici
Epidemiology of cryptosporidiosis among persons with acquired immunodeficiency syndrome in Los Angeles County.: Am J Trop Med Hyg. 1994 Sep;51(3):326-31. Unique Identifier : AIDSLINE MED/95030139; Sorvillo FJ; Lieb LE; Kerndt PR; Ash LR; HIV Epidemiology Program, Los Angeles County Department of Health; Services, California.; To determine the occurrence and factors associated with Cryptosporidium among persons with acquired immunodeficiency syndrome (AIDS) in Los Angeles County, data were analyzed from the AIDS surveillance registry for the 10-year period 1983-1992. Among 16,953 persons with AIDS, a total of 638 (3.8%) cryptosporidiosis ca
Encephalomyelitis due to a Sarcocystis neurona-like protozoan in a rhesus monkey (Macaca mulatta) infected with simian immunodeficiency virus.: Am J Trop Med Hyg. 1994 Sep;51(3):332-8. Unique Identifier : AIDSLINE MED/95030140; Klumpp SA; Anderson DC; McClure HM; Dubey JP; Yerkes Regional Primate Research Center, Emory University,; Atlanta, Georgia.; A captive-born rhesus monkey (Macaca mulatta) experimentally infected with simian immunodeficiency virus developed neurologic abnormalities approximately seven months postinoculation. A chronic necrotizing encephalomyelitis with intralesional protozoal schizonts was diagnosed histologically. The protozoa was identifie
Low prevalence of human T lymphotropic virus type I in !Kung San in Bushmanland, Namibia.: Am J Trop Med Hyg. 1994 Oct;51(4):460-5. Unique Identifier : AIDSLINE MED/95030161; Steele AD; Bos P; Joubert JJ; Evans AC; Joseph S; Tucker L; Aspinall S; Lecatsas G; Department of Virology, Medical University of Southern Africa,; Pretoria, Republic of South Africa.; Antibodies to human immunodeficiency virus 1 (HIV-1) and human T lymphotropic virus type 1 (HTLV-I) have been identified in various population groups living in southern and central Africa. Sera from 291 !Kung Bushmen in Bushmanland, Namibia were examined for the presence of antibo
Further applications for EMLA cream [letter; comment] [see comments]: Anesth Analg. 1994 Oct;79(4):814. Unique Identifier : AIDSLINE MED/95030406; Nerad JL; O'Connor CJ
Variables influencing worker compliance with universal precautions in the emergency department [see comments]: Am J Infect Control. 1994 Jun;22(3):138-48. Unique Identifier : AIDSLINE MED/95030529; Williams CO; Campbell S; Henry K; Collier P; Fairview Southdale Hospital, Edina, MN.; BACKGROUND: Emergency department health care workers frequently provide care to patients who are in unstable condition, bleeding, or in a crisis situation. To identify the variables described in the Health Belief Model affecting health care workers compliance with practices and devices believed to reduce exposure to
AIDS: problem solving in infection control. Compliance with universal precautions: Getting to Yes [comment]: Am J Infect Control. 1994 Jun;22(3):177-8. Unique Identifier : AIDSLINE MED/95030534; Valenti WM; Community Health Network, Inc., Rochester, New York.
Changing face of AIDS [news]: Am J Infect Control. 1994 Jun;22(3):192. Unique Identifier : AIDSLINE MED/95030537
Factitious HIV infection: the importance of documenting infection [see comments]: Ann Intern Med. 1994 Nov 15;121(10):763-6. Unique Identifier : AIDSLINE MED/95030662; Craven DE; Steger KA; La Chapelle R; Allen DM; Boston University School of Medicine, Massachusetts.; OBJECTIVE: To examine possible causes for factitious human immunodeficiency virus (HIV) infection among patients in an HIV clinic. DESIGN: Retrospective chart review, a case-control study, and a survey of local hospital practices for documenting HIV infection. SETTING: Clinical acquired immunodeficiency syndrome (AIDS
Effect of HIV infection and tuberculosis on hospitalizations and cost of care for young adults in the United States, 1985 to 1990.: Ann Intern Med. 1994 Nov 15;121(10):786-92. Unique Identifier : AIDSLINE MED/95030665; Rosenblum LS; Castro KG; Dooley S; Morgan M; Centers for Disease Control and Prevention, Atlanta, Georgia.; OBJECTIVE: To evaluate the effect of human immunodeficiency virus (HIV) infection and tuberculosis on hospitalizations and the cost of care. DESIGN: National Hospital Discharge Survey, a nationally representative survey of discharges from U.S. nonfederal short-stay hospitals, and statewide billing information. PATIENT
Cyclospora infection in adults infected with HIV. Clinical manifestations, treatment, and prophylaxis.: Ann Intern Med. 1994 Nov 1;121(9):654-7. Unique Identifier : AIDSLINE MED/95030682; Pape JW; Verdier RI; Boncy M; Boncy J; Johnson WD Jr; Division of International Medicine, Cornell University Medical; College, New York, NY 10021.; OBJECTIVE: To determine the prevalence and clinical manifestations of Cyclospora in Haitians infected with human immunodeficiency virus (HIV) who have diarrhea and to evaluate therapy and prophylaxis. DESIGN: Cohort study. From 1990 to 1993, stool samples were collected from adults seropositive for HIV who had had dia
Isospora belli infection associated with acalculous cholecystitis in a patient with AIDS.: Ann Intern Med. 1994 Nov 1;121(9):663-4. Unique Identifier : AIDSLINE MED/95030684; Benator DA; French AL; Beaudet LM; Levy CS; Orenstein JM; Section of Infectious Diseases, Washington Hospital Center,; Washington, DC 20010.
Clinical features of toxoplasmic retinochoroiditis in patients with acquired immunodeficiency syndrome.: Ann Ophthalmol. 1994 May-Jun;26(3):73-84. Unique Identifier : AIDSLINE MED/95030821; Pivetti-Pezzi P; Accorinti M; Tamburi S; Ciapparoni V; Abdulaziz MA; Ocular Immunovirology Service, University of Rome La Sapienza,; Italy.
Medicine in transition--emerging ethical issues in the global village.: Ann Acad Med Singapore. 1994 May;23(3):437-40. Unique Identifier : AIDSLINE MED/95030927; Purtilo RB; Creighton University, Center for Health Policy and Ethics, Omaha,; Nebraska 68178.; Two major shifts in medicine are radically altering the medical profession worldwide: the shift from a professional to a business ethic, and the shift from a hands-one therapeutic approach to one which is technology-dependent. These paradigm shifts affect the traditional medical ethics and principles of professional a
Neurological complications of peripheral and cutaneous T-cell lymphomas.: Ann Neurol. 1994 Oct;36(4):625-9. Unique Identifier : AIDSLINE MED/95030958; Kaufman DK; Habermann TM; Kurtin PJ; O'Neill BP; Department of Neurology, Mayo Clinic, Rochester, MN 55905.; To determine the frequency and pattern of neurological complications of T-cell lymphoma (TCL), we retrospectively reviewed the medical records of 316 patients with TCL diagnosed between January 1984 and May 1991. Disease entities not included in this study were lymphoblastic lymphoma, primary central nervous system ly
Polymyositis in patients infected with human T-cell leukemia virus type I: the role of the virus in the cause of the disease.: Ann Neurol. 1994 Oct;36(4):643-9. Unique Identifier : AIDSLINE MED/95030961; Leon-Monzon M; Illa I; Dalakas MC; Neuromuscular Diseases Section, National Institute of; Neurological Disorders and Stroke, National Institutes of Health,; Bethesda, MD 20892.; To investigate the mechanism of polymyositis in human T-cell leukemia virus type I (HTLV-I) infection, we studied 6 HTLV-I-positive patients, 3 with polymyositis and 3 with adult T-cell leukemia but without clinical signs of muscle disease, by (a) quantitative single or double immunocytochemistry on serial 4-microns-t
Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome [published erratum appears in Ann Neurol 1995 Jan;37(1):140]: Ann Neurol. 1994 Oct;36(4):673-6. Unique Identifier : AIDSLINE MED/95030969; Wiley CA; Achim C; Neuropathology Division, University of Pittsburgh Medical Center,; PA.; While dementia has been observed in approximately one-fourth of terminally ill patients with acquired immunodeficiency syndrome, it has been difficult to attribute this clinical disorder to a single neuropathological substrate. We used a simple and readily reproducible scale for es
Human monoclonal anti-cytomegalovirus (CMV) antibody (MSL 109): enhancement of in vitro foscarnet- and ganciclovir-induced inhibition of CMV replication.: Antiviral Res. 1994 May;24(1):17-26. Unique Identifier : AIDSLINE MED/95030975; Nokta M; Tolpin MD; Nadler PI; Pollard RB; Department of Internal Medicine, University of Texas Medical; Branch, Galveston 77555.; Human CMV causes a number of diseases that cause considerable morbidity and that can be life-threatening in immunocompromised patients, particularly those with AIDS. Ganciclovir (GCV) and Foscarnet (PFA) are currently the drugs of choice for management of CMV di
Synthesis and anti-HIV activity of some novel diaryl phosphate derivatives of AZT.: Antiviral Res. 1994 May;24(1):69-77. Unique Identifier : AIDSLINE MED/95030980; McGuigan C; Davies M; Pathirana R; Mahmood N; Hay AJ; Department of Chemistry, University of Southampton, Highfield,; UK.; Novel diaryl phosphate triester derivatives of the anti-HIV nucleoside analogue AZT have been prepared by phosphorochloridate chemistry. These materials were designed to act as membrane-soluble pro-drugs of the bio-active free nucleotides. In particul
New lipophilic alkyl/acyl dinucleoside phosphates as derivatives of 3'-azido-3'-deoxythymidine: inhibition of HIV-1 replication in vitro and antiviral activity against Rauscher leukemia virus infected mice with delayed treatment regimens.: Antiviral Res. 1994 May;24(1):79-93. Unique Identifier : AIDSLINE MED/95030981; Schwendener RA; Gowland P; Horber DH; Zahner R; Schertler A; Schott H; Department of Internal Medicine, University Hospital, Zurich,; Switzerland.; The antiretroviral activity of two new lipophilic derivatives of azidothymidine ( AZT ), N4-hexadecyl-2 -deoxyribocytidylyl-(3 ,5 )-3 -azido-2 ,3 -deoxyth- y midine (N4-hexadecyldC-AZT) and N4-palmitoyl-2 -deoxyribocytidylyl-(3 ,5 )-3 -azido-2 ,3 -deoxy
Update of legislation reported during the past year [published erratum appears in AORN J 1994 Oct;60(4):543]: AORN J. 1994 Aug;60(2):262, 265-8. Unique Identifier : AIDSLINE MED/95030990; Avery LH
DNA-protein complexes. Natural targets for DNA-hydrolyzing antibodies.: Appl Biochem Biotechnol. 1994 May-Jun;47(2-3):305-14; discussion 314-5. Unique Identifier : AIDSLINE MED/95031011; Gololobov GV; Mikhalap SV; Starov AV; Kolesnikov AF; Gabibov AG; Englehardt Institute of Molecular Biology, Russian Academy of; Sciences.; Sera of patients with different types of leukemia and acquired immune deficiency syndrome (AIDS) have been examined for the presence of the anti-DNA antibodies. DNA-hydrolyzing activity of antibodies was detected in the sera of patients with chronic lymphoid leukemia (CLL), pre-B-cell acute lymphoid leukemia (pre-B-Al
Cytomegalovirus inclusion disease presenting as a cutaneous ulcer in AIDS. Cytomegalovirus (CMV) inclusion disease.: Arch Dermatol. 1994 Oct;130(10):1312-3, 1315. Unique Identifier : AIDSLINE MED/95031202; Husain S; Evans L; Rabinowitz AD; Grossman M; Columbia University College of Physicians and Surgeons, New York,; NY.
Acquired rectovaginal fistula [see comments]: Arch Dis Child. 1994 Aug;71(2):165-6. Unique Identifier : AIDSLINE MED/95031228; Borgstein ES; Broadhead RL; Queen Elizabeth Central Hospital, Blantyre, Malawi.; Nine girls presented with an acquired rectovaginal fistula shortly after birth. All mothers tested were seropositive for HIV. It is suggested that an acquired rectovaginal fistula is an early manifestation of HIV infection in girls.
[Reiter's syndrome and urinary infection in a case of AIDS]: Arch Esp Urol. 1994 Jul-Aug;47(6):623-4. Unique Identifier : AIDSLINE MED/95031296; Angulo Cuesta J; Ullate V; Garcia E; Flores Corral N; Servicio de Urologia, Santo Hospital Civil de Bilbao, Vizcaya,; Espana.; Herein we describe a case of Reiter s syndrome coexisting with HIV infection in a female parenteral drug addict who was also predisposed to multiple genitourinary involvement. In our view. the manifestation of additional autoimmune states could herald the worsening of the prognosis of HIV infection and the nephrologic
Blood lymphocyte subsets in rats with adjuvant arthritis.: Ann Rheum Dis. 1994 Jul;53(7):461-6. Unique Identifier : AIDSLINE MED/95031306; Franch A; Castellote C; Castell M; Unitat de Fisiologia, Facultat de Farmacia, Universitat de; Barcelona, Spain.; OBJECTIVES--To determine the phenotype of peripheral blood lymphocytes during the time-course of adjuvant arthritis (AA) to detect alterations that could be involved in the pathogenesis of the arthritic process. METHODS--Phenotype analysis was performed on days 7, 14, 21, 28, 42, 56 and 70 after arthritis induction us
Tuberculosis susceptibility patterns, predictors of multidrug resistance, and implications for initial therapeutic regimens at a New York City hospital.: Arch Intern Med. 1994 Oct 10;154(19):2161-7. Unique Identifier : AIDSLINE MED/95031533; Weltman AC; Rose DN; Department of Community Medicine, Mount Sinai School of Medicine,; New York, NY.; BACKGROUND: Multidrug resistance has complicated tuberculosis therapy. We studied antibiotic susceptibilities of Mycobacterium tuberculosis and predictors of multidrug resistance to assist in determining initial drug regimens. METHODS: We conducted a case-control study based on chart review of patients with and withou
Isolation of patients with suspected tuberculosis [letter; comment]: Arch Intern Med. 1994 Oct 24;154(20):2366, 2371. Unique Identifier : AIDSLINE MED/95031556; Ashkin D; Pitchenik A
[Clinicopathologic correlation in 50 cases of acquired immunodeficiency syndrome. Retrospective study]: Arq Bras Cardiol. 1994 Feb;62(2):95-8. Unique Identifier : AIDSLINE MED/95031700; Herdy GV; Ramos R; Bazin AR; Herdy AH; Almeida PS; Ramos RG; Carrinho M; Hospital Antonio Pedro, UFF, Niteroi, RJ.; PURPOSE--To analyze myocardial abnormalities in patients of acquired immunodeficiency syndrome with clinical and pathological correlation. METHODS--We selected 50 cases, retrospectively, age ranged from 3 months to 40 years, all of them had myocardial changes and the data of clinical records fulfilled our protocol. Ca
Differences in the perceptions of HIV risk amongst dental care providers in Western Australian clinics.: Aust Dent J. 1994 Aug;39(4):233-7. Unique Identifier : AIDSLINE MED/95031759; Waddell CE; Bennett CL; Davies JL; Department of Anthropology, University of Western Australia.; This paper examines the perceived risk of occupationally contracting HIV among dental care providers. This examination is based upon responses to a mailed questionnaire from all registered dentists (76 per cent response rate, n = 550) and dental therapists (63 per cent response rate, n = 208) in Western
The octamer motif present in the Rex-1 promoter binds Oct-1 and Oct-3 expressed by EC cells and ES cells.: Biochem Biophys Res Commun. 1994 Sep 30;203(3):1795-802. Unique Identifier : AIDSLINE MED/95032062; Rosfjord E; Rizzino A; Eppley Institute for Research in Cancer and Allied Diseases,; University of Nebraska Medical Center, Omaha 68198-6805.; Rex-1 is a zinc finger-containing gene that is expressed in embryonal carcinoma (EC) cells and embryonic stem (ES) cells. Upon differentiation with retinoic acid (RA), transcription of the Rex-1 gene decreases rapidly. Analysis of the 5 -flanking region of the Rex-1 gene identified a consensus motif for the octamer fa
Enzymatic phosphorylation and pyrophosphorylation of 2',3'-dideoxyadenosine-5'-monophosphate, a key metabolite in the pathway for activation of the anti-HIV (human immunodeficiency virus) agent 2',3'-dideoxyinosine.: Biochem Pharmacol. 1994 Sep 15;48(6):1105-12. Unique Identifier : AIDSLINE MED/95032146; Nave JF; Eschbach A; Wolff-Kugel D; Halazy S; Balzarini J; Marion Merrell Dow Research Institute, Strasbourg, France.; 2 ,3 -Dideoxyadenosine-5 -monophosphate (ddAMP) is a key intermediate in the metabolic pathway involved in the activation of the anti-retroviral agent 2 ,3 -dideoxyinosine (ddI) to 2 ,3 -dideoxyadenosine-5 -triphosphate (ddATP). The potential phosphorylation of ddAMP by adenylate kinase (myokinase) and pyrophosphoryla
Phospholipid prodrug inhibitors of the HIV protease. Antiviral activity and pharmacokinetics in rats.: Biochem Pharmacol. 1994 Oct 7;48(7):1399-404. Unique Identifier : AIDSLINE MED/95032183; Hostetler KY; Richman DD; Forssen EA; Selk L; Basava R; Gardner MF; Parker S; Basava C; Department of Medicine, University of California, San Diego, La; Jolla 92093.; The aspartyl protease of the human immunodeficiency virus (HIV) is an important target for chemotherapeutic intervention because of its key role in cleaving the HIV gag-pol polyprotein during viral assembly and budding. Short peptides and peptidomimetics, which bind to the active site of the HIV aspartyl protease and
Effect of anti-HIV 2'-beta-fluoro-2',3'-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production.: Biochem Pharmacol. 1994 Oct 7;48(7):1477-81. Unique Identifier : AIDSLINE MED/95032193; Tsai CH; Doong SL; Johns DG; Driscoll JS; Cheng YC; Department of Pharmacology, Yale University School of Medicine,; New Haven, CT 06510.; Many dideoxynucleosides that are effective against human immunodeficiency virus (HIV) also are potent inhibitors of mitochondrial DNA (mtDNA) synthesis, and the resulting mtDNA decrease could be responsible for the delayed clinical toxicity sometimes observed with these drugs. The following compounds have been examine
Increased frequency of V beta 17-positive T cells in patients with rheumatoid arthritis.: Arthritis Rheum. 1994 Oct;37(10):1431-40. Unique Identifier : AIDSLINE MED/95032213; Zagon G; Tumang JR; Li Y; Friedman SM; Crow MK; Hospital for Special Surgery/Cornell University Medical College,; New York, New York 10021.; OBJECTIVE. To identify the T lymphocytes that mediate disease in rheumatoid arthritis (RA). METHODS. A panel of monoclonal antibodies reactive with T cell receptor (TCR) V beta gene products was used to analyze the RA T cell repertoire. RESULTS. Of 5 TCR V beta gene products studied, only V beta 17-positive T cells we
Characteristics of HPRT-mutant T cell lines in a lupus patient treated with cyclophosphamide.: Arthritis Rheum. 1994 Oct;37(10):1548-52. Unique Identifier : AIDSLINE MED/95032229; Wood GM; Dawisha S; Gourley M; National Institute of Arthritis and Musculoskeletal and Skin; Diseases, NIH, Bethesda, Maryland 20892.; This report describes T cell lines derived from a patient with subacute cutaneous lupus after treatment with intravenous pulse cyclophosphamide. We selected for mitotically active, hypoxanthine-guanine phosphoribosyltransferase-deficient (HPRT-) T cells, by culture in a selective medium containing 6-thioguanine. When
Reconsidering HIV screening in physicians [letter; comment]: N C Med J. 1994 Aug;55(8):321-2. Unique Identifier : AIDSLINE MED/95021800; Meriwether RA; Klimko T; Levine RH
HIV prevention programs [letter; comment]: Science. 1994 Oct 7;266(5182):16. Unique Identifier : AIDSLINE MED/95025884; Holtgrave DR; Qualls NL
HIV infection and the dentist [letter; comment] [see comments]: Aust Dent J. 1994 Aug;39(4):268-9. Unique Identifier : AIDSLINE MED/95031766; Bowell GR
Inclusion of women in AIDS clinical research: a political and legal analysis [published erratum appears in J Am Med Wom Assoc 1994 Sep-Oct;49(5):149] [see comments]: J Am Med Wom Assoc. 1994 Jul-Aug;49(4):102-4, 109. Unique Identifier : AIDSLINE MED/95015574; McGovern T; Davis M; Caschetta MB; Thirteen years into a devastating epidemic that is having a serious impact on women of color, we are only a few steps closer to genuine participation by women in AIDS clinical trials. Those who depend most heavily on research settings not only for the promise of an accessible cure, but also for life-prolonging therapi
HIV vaccines get the green light for Third World trials [news] [see comments]: Nature. 1994 Oct 20;371(6499):644. Unique Identifier : AIDSLINE MED/95021723
Staphylococcal protein A is a novel heterologous substrate for the HIV-1 protease.: J Biotechnol. 1994 Sep 15;37(1):79-83. Unique Identifier : AIDSLINE MED/95000574; Marczinovits I; Molnar J; Patthy A; Institute of Microbiology, Albert Szent-Gyorgyi Medical; University, Szeged, Hungary.; Upon in vitro processing of the recombinant HIV-1/gag p24 protein, expressed in Escherichia coli as a fusion protein, by HIV-1 protease, a cleavage site within the staphylococcal protein A fusion partner was found. N-terminal sequencing of the protein A fragments showed that HIV-1 protease cleavage occurred between ph
Neurologic manifestations of HIV infection [published erratum appears in Ann Intern Med 1995 Feb 15;122(4):317] [see comments]: Ann Intern Med. 1994 Nov 15;121(10):769-85. Unique Identifier : AIDSLINE MED/95030664; Simpson DM; Tagliati M; Mount Sinai Medical Center, New York, New York.; PURPOSE: To review the clinical features, pathogenetic mechanisms, and management of neurologic manifestations of human immunodeficiency virus (HIV) infection. DATA SOURCES: Studies published from 1983 to 1994 identified by MEDLINE literature search; Centers for Disease Control and Prevention reports; recent communica
Prevention of occupational transmission of human immunodeficiency virus and hepatitis B virus among anesthesiologists: a survey of anesthesiology practice [see comments]: Anesth Analg. 1994 Oct;79(4):623-8. Unique Identifier : AIDSLINE MED/95030362; Tait AR; Tuttle DB; Department of Anesthesiology, University of Michigan Medical; Center, Ann Arbor 48109.; In light of the increasing prevalence of the human immunodeficiency virus (HIV) and hepatitis B virus (HBV), anesthesiologists are now likely to see more patients who are at high risk for these viruses. Therefore, it is important that they adopt infection control policies aimed at preventing occupational transmission
[Epidemiology of AIDS and tuberculosis]: Bol Oficina Sanit Panam. 1994 Jun;116(6):546-65. Unique Identifier : AIDSLINE MED/95000301; Garcia Garcia ML; Valdespino Gomez JL; Garcia Sancho MC; Salcedo Alvarez RA; Zacarias F; Sepulveda Amor J; Instituto Nacional de Diagnostico y Referencia Epidemiologicos,; Mexico, DF, Mexico.
V3 region polymorphisms in HIV-1 from Brazil: prevalence of subtype B strains divergent from North American/European prototype and detection of subtype F.: AIDS Res Hum Retroviruses. 1994 May;10(5):569-76. Unique Identifier : AIDSLINE GENBANK/U00427; Morgado MG; Sabino EC; Shpaer EG; Bongertz V; Brigido L; Guimaraes MD; Castilho EA; Galvao-Castro B; Mullins JI; Hendry RM; et al; Department of Immunology, Instituto Oswaldo Cruz, FIOCRUZ, Rio de; Janeiro, Brazil.; Viral DNA sequences were determined over the V3 region of env from 28 infected individuals living in the high HIV-1 prevalence Brazilian cities of Rio de Janeiro and Sao Paulo. Twenty-six belonged to envelope sequence subtype B, prevalent in North America and Europe, and one was classified as subtype F, found recently
Reactions of Ugandan antisera with peptides encoded by V3 loop epitopes of human immunodeficiency virus type 1.: AIDS Res Hum Retroviruses. 1994 May;10(5):577-83. Unique Identifier : AIDSLINE MED/95000930; Smith JD; Bruce CB; Featherstone AS; Downing RG; Biryahawaho B; Clegg JC; Carswell JW; Oram JD; Division of Pathology, Centre for Applied Microbiology and; Research, Porton Down, Salisbury, England.; The specificities of antibodies reacting with peptides encoded by V3 loop apical epitopes were determined for sera from 230 seropositive Ugandans, including asymptomatic persons and AIDS patients, sampled between 1986 and 1992. Most (71%) of the sera reacted with the peptide encoded by HIV-MN, 59% reacted with a pepti
Interaction of the reverse transcriptase of human immunodeficiency virus type 1 with DNA.: Biochemistry. 1994 Oct 11;33(40):12222-8. Unique Identifier : AIDSLINE MED/95001939; Bakhanashvili M; Hizi A; Department of Cell Biology and Histology, Sackler School of; Medicine, Tel Aviv University, Israel.; During DNA synthesis, the binding of human immunodeficiency virus (HIV) reverse transcriptase (RT) to the template-primer precedes its binding to nucleotide triphosphates. The interaction of oligonucleotide DNA with HIV-1 RT was investigated by using a gel retardation assay. Both homodimeric (p66/p66) and heterodimeri
Characterization of an RNase H deficient mutant of human immunodeficiency virus-1 reverse transcriptase having an aspartate to asparagine change at position 498.: Biochim Biophys Acta. 1994 Oct 18;1219(2):380-8. Unique Identifier : AIDSLINE MED/95002151; DeStefano JJ; Wu W; Seehra J; McCoy J; Laston D; Albone E; Fay PJ; Bambara RA; Department of Biochemistry, University of Rochester, NY 14642.; It has been proposed that Asp-443, Glu-478, and Asp-498 are important in RNase H mediated catalysis by human immunodeficiency virus-1 reverse transcriptase (Davies J.F., Hostomska, Z. Hostomsky, Z., Jordan , S.R. and Matthews, D.A. (
Changes in the level of blood suppressor CD8+CD57+ lymphocytes, when HIV-1 p24 antigen reappears in the blood.: Biomed Pharmacother. 1994;48(1):3-5. Unique Identifier : AIDSLINE MED/95002655; Mathe G; Morette C; Hallard M; Sala M; Orbach-Arbouys S; Institut de Cancerologie et d'Immunologie Hopital Suisse de; Paris, Issy-les-Moulineaux, France.; Using the marker Leu2 + Leu7 + to detect the CD8 suppressor cells (CD88+CD57+), we have observed that their blood level, which increases after primoinfection, during the latent period, increases still further just before and when the p24 antigen returns and is present in the blood. Its ratio over cytotoxic CD8+ cells
Lovastatin inhibits HIV-1 expression in H9 human T lymphocytes cultured in cholesterol-poor medium.: Biomed Pharmacother. 1994;48(2):63-7. Unique Identifier : AIDSLINE MED/95002662; Maziere JC; Landureau JC; Giral P; Auclair M; Fall L; Lachgar A; Achour A; Zagury D; Laboratoire de Biochimie, Faculte de Medecine Saint-Antoine,; Paris, France.; The effects of the HMG-Coenzyme A reductase inhibitor lovastatin on HIV-1 expression and sterol synthesis have been investigated in the human H9 lymphocytic cell line. To this purpose, sterol synthesis from 14C-acetate, cell multiplication and reverse transcriptase activity have been measured in parallel at various ti
Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion.: Blood. 1994 Oct 15;84(8):2622-31. Unique Identifier : AIDSLINE MED/95002983; Oyaizu N; McCloskey TW; Than S; Hu R; Kalyanaraman VS; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, NY.; We have recently shown that, in unfractioned peripheral blood mononuclear cells (PBMCs), the cross-linking of CD4 molecules (CD4XL) is sufficient to induce T-cell apoptosis. However, the underlying mechanism for the CD4XL-mediated T-cell apoptosis is largely unknown. Several recent studies have shown that Fas antigen
Human T-cell leukemia virus type I tax/rex DNA and RNA in cutaneous T-cell lymphoma.: Blood. 1994 Oct 15;84(8):2663-71. Unique Identifier : AIDSLINE MED/95002987; Ghosh SK; Abrams JT; Terunuma H; Vonderheid EC; DeFreitas E; Department of Medicine, University of Miami, School of Medicine,; FL 33101.; Peripheral blood mononuclear cells (PBMCs) and T-cell lines from patients with Sezary syndrome (SS) and skin lesions from patients with mycosis fungoides (MF) were examined by polymerase chain reaction (PCR) for DNA sequences homologous to the human retroviruses human T-lymphotropic virus (HTLV)-I and -II. Results obt
Identification and culture of Kaposi's sarcoma-like spindle cells from the peripheral blood of human immunodeficiency virus-1-infected individuals and normal controls.: Blood. 1994 Oct 15;84(8):2711-20. Unique Identifier : AIDSLINE MED/95002992; Browning PJ; Sechler JM; Kaplan M; Washington RH; Gendelman R; Yarchoan R; Ensoli B; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.; We examined 26 patients with human immunodeficiency virus-1 (HIV-1)-associated Kaposi s sarcoma (KS), and 76 HIV-1-infected (HIV-1+) people without KS or uninfected (HIV-1-) controls for the presence of circulating KS-like spindle cells. Adherent cells that had spindle morphology and several characteristics of spindle
Polymorphonuclear neutrophils from human immunodeficiency virus-infected patients show enhanced activation, diminished fMLP-induced L-selectin shedding, and an impaired oxidative burst after cytokine priming.: Blood. 1994 Oct 15;84(8):2759-66. Unique Identifier : AIDSLINE MED/95002998; Elbim C; Prevot MH; Bouscarat F; Franzini E; Chollet-Martin S; Hakim J; Gougerot-Pocidalo MA; INSERM U294, Paris, France.; Impaired polymorphonuclear neutrophil (PMN) function may contribute to the onset of certain life-threatening bacterial and fungal infections in human immunodeficiency virus (HIV)-infected patients. Published data on PMN functional activity in HIV infection are controversial, possibly because most studies have involved
Palliative high-dose octreotide in a case of severe AIDS-related diarrhea [letter]: Ann Pharmacother. 1994 Jun;28(6):806-7. Unique Identifier : AIDSLINE MED/95003262; Kim-Sing A; Yoshida EM; Whittaker JS
Heparin mediates binding of S-protein/vitronectin to the envelope glycoprotein of the human immunodeficiency virus and CD4.: Int Arch Allergy Immunol. 1994 Nov;105(3):238-44. Unique Identifier : AIDSLINE MED/95003753; Su HR; Boackle RJ; Department of Stomatology, Medical University of South Carolina,; Charleston 29425-2230.; Using normal human serum and EDTA-plasma as the two sources of S-protein (vitronectin) in an enzyme-linked immunosorbent assay, we determined that heparin pretreatment of immobilized rgp120 or of immobilized CD4 caused the serum form of S-protein to deposit in a dose-dependent manner. Interestingly, the EDTA-plasma fo
[Immunobiologic characteristics of hybrid proteins consisting of tumor necrosis factor alpha and thymosin alpha 1]: Vestn Ross Akad Med Nauk. 1994;(6):55-61. Unique Identifier : AIDSLINE MED/95003864; Shmelev VA; Khromykh LM; Dudich EI; Sheviakova LIa; Gorbatova EA; Galaktionov VG; The preparations of alpha 1-thymosin (T), alpha-tumor necrotic factor (TNF) and their based hybrid proteins: T-TNF, TNF-T, and T-TNF-T were studied by using a wide spectrum of immunobiological tests. In the L-929 cells, T-TNF preserved cytotoxicity unique to TNF; TNF-T preserved it 10 times less, and T-NTF-T was compl
Specific ligation of the HIV-1 viral envelope protein gp120 on human CD34+ bone marrow-derived progenitors.: Cell Mol Biol (Noisy-le-grand). 1994 May;40(3):319-23. Unique Identifier : AIDSLINE MED/95003953; Arock M; Dedenon A; Le Goff L; Michel A; Missenard G; Debre P; Guillosson JJ; Laboratory of Hematology, Faculty of Pharmacy, Paris, France.; The precise mechanisms of hematologic abnormalities observed during HIV infection remain unknown. In vitro experiments performed by various authors concerning the HIV toxicity on bone marrow-derived precursors did not allow them to determine whether this toxicity could be mediated through direct or non-direct effects,
Strategies to reduce vertical transmission of HIV-1.: Commun Dis Rep CDR Wkly. 1994 Jul 15;4(28):127; 130. Unique Identifier : AIDSLINE MED/95005031
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1994 Jul 15;4(28):131-4. Unique Identifier : AIDSLINE MED/95005032
AIDS and HIV-1 infection in the United Kingdom: monthly report.: Commun Dis Rep CDR Wkly. 1994 Aug 12;4(32):155-6. Unique Identifier : AIDSLINE MED/95005037
High-performance liquid chromatography and photoaffinity crosslinking to explore the binding environment of nevirapine to reverse transcriptase of human immunodeficiency virus.: J Chromatogr A. 1994 Jul 29;676(1):99-112. Unique Identifier : AIDSLINE MED/95005380; Palladino DE; Hopkins JL; Ingraham RH; Warren TC; Kapadia SR; Van Moffaert GJ; Grob PM; Stevenson JM; Cohen KA; Department of Analytical Sciences, Boehringer Ingelheim; Pharmaceuticals, Inc., Ridgefield, CT 06877-0368.; Nevirapine (BI-RG-587) is a potent inhibitor of the polymerase activity of reverse transcriptase of human immunodeficiency virus type-1. Nevirapine, as well as several other non-nucleoside compounds of various structural classes, bind strongly at a site which includes tyrosines 181 and 188 of the p66 subunit of revers
Positive selection of human blood cells using improved high gradient magnetic separation filters.: J Hematother. 1993 Fall;2(3):297-303. Unique Identifier : AIDSLINE MED/95006262; Thomas TE; Richards AJ; Roath OS; Watson JH; Smith RJ; Lansdorp PM; Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver,; Canada.; High gradient magnetic separators (HGMS) create magnetic field gradients that can be used to attract much smaller and less magnetic particles than those required for conventional magnetic separation techniques. As a result cells can be labeled with submicron magnetic particles and still be separated using an HGMS filt
[Prevalence of HIV and HCV among injecting drug users (IDUs) in Yunnan, China]: Chung Hua Liu Hsing Ping Hsueh Tsa Chih. 1994 Apr;15(2):74-5. Unique Identifier : AIDSLINE MED/95007735; Li D; Zheng X; Zhang G; Institute of Epidemiology and Microbiology, Chinese Academy of; Preventive Medicine, Beijing.; Prevalence of HIV and HCV was studied among 507 IDUs in Yunnan Province. The results reveal that sharing needles with other IDUs is one of the primary pathways to transmit both HIV and HCV. The rates of HIV and HCV infection in the IDU group is 66.5% and 94.9% respectively, which is significantly higher than those in
Suppression of cytokine-dependent human T-cell proliferation by intravenous immunoglobulin.: Clin Immunol Immunopathol. 1994 Nov;73(2):180-6. Unique Identifier : AIDSLINE MED/95008390; Amran D; Renz H; Lack G; Bradley K; Gelfand EW; Department of Pediatrics, National Jewish Center for Immunology; and Respiratory Medicine, Denver, Colorado 80206.; Human intravenous immunoglobulin (hIVIG) modifies the course of numerous immune-mediated diseases, but its specific mode of action remains unknown. In order to delineate possible immunoregulatory mechanisms, we studied the effects of hIVIG on the in vitro proliferation of human T cells. Cells from normal donors were s
HIV-1 gp160 as a modifier of Th1 and Th2 cytokine response: gp160 suppresses interferon-gamma and interleukin-2 production concomitantly with enhanced interleukin-4 production in vitro.: Clin Immunol Immunopathol. 1994 Nov;73(2):245-51. Unique Identifier : AIDSLINE MED/95008398; Hu R; Oyaizu N; Kalyanaraman VS; Pahwa S; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, New York, New York 11030.; Disease progression in HIV-1 infection is reported to be associated with a gradual shift in CD4+ T cell function from a Th type 1 to a Th type 2 of response, but the underlying mechanism remains unclear. In this study, the effect of HIV-1 envelope glycoprotein gp160 on secretion of cytokines IFN-gamma/
Development and significance of nucleoside drug resistance in infection caused by the human immunodeficiency virus type 1.: Clin Invest Med. 1994 Jun;17(3):226-43. Unique Identifier : AIDSLINE MED/95008468; Smith M; Salomon H; Wainberg MA; McGill University AIDS Centre, Lady Davis Institute, Jewish; General Hospital, Montreal, Quebec.; Nucleoside antagonists of human immunodeficiency virus (HIV) reverse transcriptase (RT) activity have been commonly used in the therapy of HIV-associated disease. The prolonged use of such drugs has led to the development of HIV variants that display resistance against these compounds. HIV drug resistance has been doc
Clinical application of reverse transcription-polymerase chain reaction for HIV infection.: Clin Lab Med. 1994 Jun;14(2):335-49. Unique Identifier : AIDSLINE MED/95008669; Holodniy M; Division of Infectious Diseases, Department of Veterans Affairs; Medical Center, Palo Alto, California.; This article describes the current knowledge of the various RT-PCR assays and their clinical application in HIV disease. The importance of assay precision and sample handling is emphasized. A review of quantification techniques is also presented. Finally, the relevant literature describing the application of RT-PCR fo
Therapy other than reverse transcriptase inhibitors for HIV infection.: Clin Lab Med. 1994 Jun;14(2):367-91. Unique Identifier : AIDSLINE MED/95008671; Kaplan JC; Hirsch MS; Infectious Disease Unit, Massachusetts General Hospital, Boston.; Antiretroviral drugs against HIV infection have been developed that inhibit various stages of the HIV replication cycle. Agents other than reverse transcriptase inhibitors are reviewed with particular attention to those under study in clinical trials, including inhibitors of the virus-encoded protease enzyme. In addit
HIV-1 drug resistance. Molecular pathogenesis and laboratory monitoring.: Clin Lab Med. 1994 Jun;14(2):393-422. Unique Identifier : AIDSLINE MED/95008672; D'Aquila RT; Infectious Disease Unit, Masschusetts General Hospital, Boston.; Molecular and clinical aspects of HIV-1 pathogenesis are described, including the turnover of the HIV-1 population in vivo, the clinical significance of resistance to HIV-1 reverse transcriptase (RT) inhibitors, and the inter-relationship between virus replication and RT inhibitor resistance. The molecular genetics of
Envelope sequence variation, neutralizing antibodies, and primate lentivirus persistence.: Curr Top Microbiol Immunol. 1994;188:185-219. Unique Identifier : AIDSLINE MED/95008914; Burns DP; Desrosiers RC; New England Regional Primate Research Center, Harvard Medical; School, Southborough, MA 01772-9102.; Studies in ungulate lentivirus systems clearly indicate that neutralization escape variants emerge over time in chronically infected animals. Studies in the EIAV system, in particular, have provided strong evidence that the humoral branch of the immune system is at least one selective force acting on an array of viral
Cytotoxic T lymphocytes in human immunodeficiency virus infection: responses to structural proteins.: Curr Top Microbiol Immunol. 1994;189:35-63. Unique Identifier : AIDSLINE MED/95008926; Johnson RP; Walker BD; Infectious Disease Unit, Massachusetts General Hospital, Harvard; Medical School, Boston 02114.
Induction of HIV-1 envelope (gp120)-specific cytotoxic T lymphocyte responses in mice by recombinant CHO cell-derived gp120 is enhanced by enzymatic removal of N-linked glycans.: Eur J Immunol. 1994 Oct;24(10):2369-76. Unique Identifier : AIDSLINE MED/95010251; Doe B; Steimer KS; Walker CM; Department of Virology, Chiron Corporation, Emeryville, CA 94608.; Priming of CD8+ cytotoxic T lymphocyte (CTL) responses with recombinant proteins has been facilitated by the development of novel adjuvants that deliver antigens into the class I major histocompatibility complex (MHC) pathway. However, the extent to which secondary structure or glycosylation of these proteins prevents
Increased Fas antigen expression in murine retrovirus-induced immunodeficiency syndrome, MAIDS.: Eur J Immunol. 1994 Oct;24(10):2446-51. Unique Identifier : AIDSLINE MED/95010262; Hiromatsu K; Aoki Y; Makino M; Matsumoto Y; Mizuochi T; Gotoh Y; Nomoto K; Ogasawara J; Nagata S; Yoshikai Y; Laboratory of Germfree Life, Research Institute for Disease,; Nagoya University School of Medicine, Japan.; The Fas antigen (Fas), which is a cell surface protein belonging to the tumor necrosis factor receptor family, mediates apoptosis. To assess the contribution of Fas to the pathogenesis of retrovirus-induced immunodeficiency, we examined the kinetics of Fas expression on the lymphocytes during the course of murine acqu
Seasonal variation in peripheral blood leukocyte subsets and in serum interleukin-6, and soluble interleukin-2 and -6 receptor concentrations in normal volunteers.: Experientia. 1994 Sep 15;50(9):821-9. Unique Identifier : AIDSLINE MED/95010577; Maes M; Stevens W; Scharpe S; Bosmans E; De Meyer F; D'Hondt P; Peeters D; Thompson P; Cosyns P; De Clerck L; et al; Department of Psychiatry, Case Western Reserve University,; Cleveland, Ohio.; This study has been carried out in order to investigate seasonal variation in peripheral blood immune cells, such as leukocytes, monocytes, neutrophils, lymphocytes, CD3+ T, CD4+ T, CD8+ T, CD25+ T, CD20+ B, and serum interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R) and sIL-2R levels in normal volunteers. Toward t
Immunoreactivity of chimeric proteins carrying the HIV-1 epitope IGPGRAF. Correlation between predicted conformation and antigenicity.: FEBS Lett. 1994 Oct 10;353(1):1-4. Unique Identifier : AIDSLINE MED/95010750; Tisminetzky SG; Scodeller EA; Evangelisti P; Chen Y; Schiappacassi M; Porro F; Bizik F; Zacchi T; Lunazzi G; Miertus S; et al; International Centre for Genetic Engineering and Biotechnology,; Trieste, Italy.; Sera from HIV-1 infected individuals were examined for their reactivity to the principal neutralizing domain, IGPGRAF sequence, of the V3-loop of HIV-1. Four hybrid proteins carrying this sequence inserted in four different outer loops of a protein that makes up the capsid of an insect virus were used as antigen in a
Management of a tracheoesophageal fistula with a silicone-covered self-expanding metal stent.: Gastrointest Endosc. 1994 Jul-Aug;40(4):497-9. Unique Identifier : AIDSLINE MED/95011347; Nelson DB; Silvis SE; Ansel HJ; Minneapolis VA Medical Center, Minnesota.
Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase.: J Biol Chem. 1994 Sep 30;269(39):24195-202. Unique Identifier : AIDSLINE MED/95014157; Zinnen S; Hsieh JC; Modrich P; Department of Biochemistry, Duke University Medical Center,; Durham, North Carolina 27710.; Pre-steady-state methods were used to study the fidelity of human immunodeficiency virus reverse transcriptase. Fidelity of DNA-directed DNA synthesis can be attributed to a 1-2 order of magnitude reduction in affinity for noncomplementary dNTPs, and a 1-4 order of magnitude reduction in the rate of the conformational
Nitric oxide reduces early growth response-1 gene expression in rat lung macrophages treated with interferon-gamma and lipopolysaccharide.: J Biol Chem. 1994 Oct 14;269(41):25239-42. Unique Identifier : AIDSLINE MED/95014308; Henderson SA; Lee PH; Aeberhard EE; Adams JW; Ignarro LJ; Murphy WJ; Sherman MP; Department of Physiological Science, UCLA 90024.; Since early growth response-1 (Egr-1) is required for macrophage differentiation and nitric oxide (NO) is immunosuppressive, we hypothesized that NO would reduce Egr-1 expression in rat lung macrophages. The inflammatory stimuli interferon-gamma and lipopolysaccharide induced an early, transient increase in Egr-1 mRNA
Resistance of HIV-1 reverse transcriptase against [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'- ',2''- oxathiole-2'',2''-dioxide)] (TSAO) derivatives is determined by the mutation Glu138-->Lys on the p51 subunit.: J Biol Chem. 1994 Oct 14;269(41):25255-8. Unique Identifier : AIDSLINE MED/95014312; Jonckheere H; Taymans JM; Balzarini J; Velazquez S; Camarasa MJ; Desmyter J; De Clercq E; Anne J; Rega Institute for Medical Research, Katholieke Universiteit; Leuven, Belgium.; Determination of the three-dimensional structure of the human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) has indicated a totally different folding for the 51-kDa subunit (p51) than for the 66-kDa subunit (p66). The polymerase catalytic site is located on the p66 subunit. Moreover, the HIV-1-speci
Structure-specific cleavage of the RNA primer from Okazaki fragments by calf thymus RNase HI.: J Biol Chem. 1994 Oct 14;269(41):25922-7. Unique Identifier : AIDSLINE MED/95014406; Huang L; Kim Y; Turchi JJ; Bambara RA; Department of Biochemistry, University of Rochester, School of; Medicine and Dentistry, New York 14642.; Cleavage specificity of RNase HI was examined on model Okazaki fragments, to determine the likely role of this nuclease in lagging strand DNA replication. Each substrate was prepared by annealing a short RNA primer, made by transcription in vitro, to a single-stranded synthetic DNA template, and subsequently extending
Mutating the primer grip of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization.: J Biol Chem. 1994 Oct 21;269(42):26472-8. Unique Identifier : AIDSLINE MED/95014489; Jacques PS; Wohrl BM; Ottmann M; Darlix JL; Le Grice SF; Department of Biochemistry, Case Western Reserve University; School of Medicine, Cleveland, Ohio.; BcgI cassette mutagenesis was used to prepare variants of p66 human immunodeficiency virus (HIV)-1 reverse transcriptase with amino acid substitutions between residues Glu224 and Trp229. Mutant polypeptides were reconstituted in vitro with wild type p51 to generate the selectively mutated heterodimer series p66(224A)/
Exogenous tat protein activates central nervous system-derived endothelial cells.: J Neuroimmunol. 1994 Oct;54(1-2):19-28. Unique Identifier : AIDSLINE MED/95014981; Hofman FM; Dohadwala MM; Wright AD; Hinton DR; Walker SM; Department of Pathology, University of Southern California School; of Medicine, Los Angeles 90033.; Tat protein, an HIV gene product known to be secreted extracellularly, was tested to determine its role in the dissemination of HIV into the central nervous system (CNS). Tat was shown to activate human CNS-derived endothelial cells (CNS-EC) by the increase in the expression of E-selectin, the synthesis of IL-6, and t
Characterization of the activation-associated isoform of CD43 on murine T lymphocytes.: J Immunol. 1994 Oct 15;153(8):3426-39. Unique Identifier : AIDSLINE MED/95015830; Jones AT; Federsppiel B; Ellies LG; Williams MJ; Burgener R; Duronio V; Smith CA; Takei F; Ziltener HJ; Biomedical Research Center, Vancouver, Canada.; A rat mAb termed 1B11 recognizes a 130-kDa cell surface glycoprotein expressed on T lymphocytes. Transfection studies using the Cd43 gene transfected into murine L cells, and immunoblots using anti-peptide Abs specific for the CD43 polypeptide identified the 1B11 Ag as the 130-kDa isoform of murine CD43. mAb 1B11 fail
Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.: J Immunol. 1994 Oct 15;153(8):3603-10. Unique Identifier : AIDSLINE MED/95015849; Young HA; Ghosh P; Ye J; Lederer J; Lichtman A; Gerard JR; Penix L; Wilson CB; Melvin AJ; McGurn ME; et al; Laboratory of Experimental Immunology, NCI-FCRDC, MD.; Th1 and Th2 CD4+ T cell clones have been defined by their ability to produce different lymphokines. However, the processes by which CD4+ T cells differentially regulate lymphokine gene expression have not been well defined. In this report, we demonstrate that the methylation status of a CpG dinucleotide contained with
Clonal expansion but lack of subsequent clonal deletion of bacterial superantigen-reactive T cells in murine retroviral infection.: J Immunol. 1994 Oct 15;153(8):3611-21. Unique Identifier : AIDSLINE MED/95015850; Aoki Y; Hiromatsu K; Usami J; Makino M; Igarashi H; Ogasawara J; Nagata S; Yoshikai Y; Laboratory of Host Defense, Nagoya University School of Medicine,; Japan.; Several studies have suggested that activation-induced apoptosis of Ag-specific CD4+ T cells leads to depletion of this subset during HIV infection. The bacterial superantigen, staphylococcal enterotoxin A (SEA), is known to induce activation-induced apoptosis in the TCR V beta-bearing CD4+ T cells in the periphery af
A region of the third variable loop of HIV-1 gp120 is recognized by HLA-B7-restricted CTLs from two acute seroconversion patients.: J Immunol. 1994 Oct 15;153(8):3822-30. Unique Identifier : AIDSLINE MED/95015873; Safrit JT; Lee AY; Andrews CA; Koup RA; Aaron Diamond AIDS Research Center and the Department of Medicine; and Microbiology, New York University, School of Medicine, New; York 10016.; HIV-1 envelope-specific CTL clones were isolated from the peripheral blood of two patients from within weeks of seroconversion. These clones were CD8+ and restricted by the HLA-B7 molecule. The minimum epitope recognized by the clones was determined to be the 30-amino acid (aa) sequence RPNNNTRKSI within the third var
Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis.: J Immunol. 1994 Nov 1;153(9):4142-8. Unique Identifier : AIDSLINE MED/95015904; Corry DB; Reiner SL; Linsley PS; Locksley RM; Department of Medicine, UCSF 94143.; Infection of inbred strains of mice with Leishmania major is a well-characterized model for analysis of the development of effector CD4+ subsets of the Th1 and Th2 types in vivo. We co-administered a fusion protein, CTLA4Ig, that blocks the CD28-B7 costimulatory pathway important for optimal T cell activation, to asse
HIV-1 suppression of hematopoiesis in vitro mediated by envelope glycoprotein and TNF-alpha.: J Immunol. 1994 Nov 1;153(9):4303-10. Unique Identifier : AIDSLINE MED/95015920; Maciejewski JP; Weichold FF; Young NS; Hematology Branch, National Heart, Lung and Blood Institute,; National Cancer Institute, Bethesda, MD. 20892.; Dysmorphic marrow morphology and bone marrow failure are common in AIDS patients, but the mechanism of HIV-1 effects on blood cell production is unclear. Experiments to test the susceptibility of hematopoietic progenitor cells to HIV-1 infection have led to conflicting results. We found that hematopoietic colony forma
Enzyme immunoassay (ELISA) for the evaluation of antibodies directed to the CD4 receptor-binding site of the HIV gp120 molecule.: J Immunol Methods. 1994 Sep 30;175(1):37-46. Unique Identifier : AIDSLINE MED/95015933; Hinkula J; Gidlund M; Persson C; Osterhaus A; Wahren B; Swedish Institute for Infectious Disease Control, Department of; Virology, Stockholm.; The interaction between the HIV envelope glycoprotein gp120 and the CD4 molecule is probably the most important primary event determining HIV infection. Reactivity with the native viral envelope has been difficult to measure due to the lack of gp120 ligand purified directly from primary virus cultures. We have develop
Bacillary angiomatosis: investigation of the unusual interactions between Rochalimaea bacilli and endothelial cells [editorial; comment]: J Lab Clin Med. 1994 Oct;124(4):475-7. Unique Identifier : AIDSLINE MED/95016211; Koehler JE
Naturally processed viral peptides recognized by cytotoxic T lymphocytes on cells chronically infected by human immunodeficiency virus type 1.: J Exp Med. 1994 Oct 1;180(4):1283-93. Unique Identifier : AIDSLINE MED/95016420; Tsomides TJ; Aldovini A; Johnson RP; Walker BD; Young RA; Eisen HN; Center for Cancer Research, Massachusetts Institute of; Technology, Cambridge 02139.; We have established long-term cultures of several cell lines stably and uniformly expressing human immunodeficiency virus type 1 (HIV-1) in order to (a) identify naturally processed HIV-1 peptides recognized by cytotoxic T lymphocytes (CTL) from HIV-1-seropositive individuals and (b) consider the hypothesis that natur
A rodent cell line permissive for entry and reverse transcription of human immunodeficiency virus type 1 has a pre-integration block to productive infection.: J Gen Virol. 1994 Oct;75 ( Pt 10):2615-23. Unique Identifier : AIDSLINE MED/95016513; Simon JH; Schockmel GA; Illei P; James W; Sir William Dunn School of Pathology, University of Oxford, U.K.; Replication of human immunodeficiency virus type 1 (HIV-1) is restricted to CD4-expressing primate cells. This tropism may be due partly to the absence from nonprimate cells of a species-specific factor which has an accessory role to CD4 during virus penetration. In this study we describe a rat B lymphocyte cell line
Diagnosis of HIV-1 infection by detection of antibody IgG to HIV-1 in urine with ultrasensitive enzyme immunoassay (immune complex transfer enzyme immunoassay) using recombinant proteins as antigens.: J Clin Lab Anal. 1994;8(4):237-46. Unique Identifier : AIDSLINE MED/95017266; Hashida S; Hashinaka K; Saitoh A; Takamizawa A; Shinagawa H; Oka S; Shimada K; Hirota K; Kohno T; Ishikawa S; et al; Department of Biochemistry, Medical College of Miyazaki, Japan.; Anti-HIV-1 IgG in urine was detected by an ultrasensitive enzyme immunoassay (immune complex transfer enzyme immunoassay) using recombinant reverse transcriptase (RT), p17 and p24 as antigens, and beta-D-galactosidase from Escherichia coli as label. Anti-HIV-1 IgG in urine was reacted simultaneously with 2,4-dinitroph
Co-expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells.: J Pathol. 1994 May;173(1):23-31. Unique Identifier : AIDSLINE MED/95017285; Uccini S; Ruco LP; Monardo F; Stoppacciaro A; Dejana E; La Parola IL; Cerimele D; Baroni CD; II Pathological Anatomy, University La Sapienza, Roma, Italy.; The histopathogenesis of Kaposi s sarcoma (KS) was investigated using immunocytochemistry in 12 skin biopsies obtained from two AIDS patients, nine patients with the classic form, and one organ-transplant patient. KS cells revealed a peculiar antigenic profile, being characterized by co-expression of endothelial and m
Preferential antibody recognition of structurally distinct HIV-1 gp120 molecules.: J Acquir Immune Defic Syndr. 1994 Nov;7(11):1103-15. Unique Identifier : AIDSLINE MED/95017541; VanCott TC; Bethke FR; Kalyanaraman V; Burke DS; Redfield RR; Birx DL; Department of Retroviral Research, Walter Reed Army Institute of; Research, Rockville, Maryland.; We have developed an assay, using a biosensor matrix and surface plasmon resonance, that rapidly and reproducibly measures antibody reactivity to human immunodeficiency virus type 1 (HIV-1) gp120 in various structural conformations. In particular, antibodies displaying preferential reactivity to a CD4-binding competen
Synthesis and evaluation of the anti-HIV activity of aza and deaza analogues of isoddA and their phosphates as prodrugs.: J Med Chem. 1994 Oct 14;37(21):3534-41. Unique Identifier : AIDSLINE MED/95018071; Franchetti P; Cappellacci L; Grifantini M; Messini L; abu Sheikha G; Loi AG; Tramontano E; de Montis A; Spiga MG; La Colla P; Dipartimento di Scienze Chimiche, Universita di Camerino, Italy.; Some aza and deaza analogues of the anti-HIV agent 2 ,3 -dideoxy-3 -oxoadenosine (isoddA) (8-aza-, 8-aza-1-deaza, 8-aza-3-deaza-, 1-deaza-, and 3-deaza-isoddA) were synthesized and found inactive against HIV in vitro. The hypothesis that the inactivity of these isonucleosides might be due to their poor affinity for ce
Crystals of HIV-1 reverse transcriptase diffracting to 2.2 A resolution.: J Mol Biol. 1994 Sep 30;242(4):586-8. Unique Identifier : AIDSLINE MED/95018222; Stammers DK; Somers DO; Ross CK; Kirby I; Ray PH; Wilson JE; Norman M; Ren JS; Esnouf RM; Garman EF; et al; Wellcome Research Laboratories, Beckenham, Kent, U.K.; Reverse transcriptase (RT) from the human immunodeficiency virus type 1 has been crystallized in four closely related forms, the best of which diffract X-rays to 2.2 A resolution. The RT was crystallized as a complex with a non-nucleoside inhibitor, either
Structural mimicry and enhanced immunogenicity of peptide epitopes displayed on filamentous bacteriophage. The V3 loop of HIV-1 gp120.: J Mol Biol. 1994 Oct 21;243(2):167-72. Unique Identifier : AIDSLINE MED/95018258; di Marzo Veronese F; Willis AE; Boyer-Thompson C; Appella E; Perham RN; Advanced BioScience Laboratories Inc., Kensington, MD 20895.; The principal neutralizing determinant of the human immunodeficiency virus type 1 (HIV-1) is an intra-chain disulphide-bridged loop, designated V3, in the third hypervariable region of the surface glycoprotein gp120. Peptide sequences from the V3 loop of gp120 from HIV-1 strain MN (HIV-1MN) were engineered into the N-
Scanning mutagenesis of the arginine-rich region of the human immunodeficiency virus type 1 Rev trans activator.: J Virol. 1994 Nov;68(11):7329-35. Unique Identifier : AIDSLINE MED/95018645; Hammerschmid M; Palmeri D; Ruhl M; Jaksche H; Weichselbraun I; Bohnlein E; Malim MH; Hauber J; SANDOZ Research Institute, Vienna, Austria.; The structural proteins of human immunodeficiency virus type 1, for example, Gag and Env, are encoded by unspliced and incompletely spliced viral transcripts. The expression of these mRNAs in the cytoplasm, along with their commensurate translation, is absolutely dependent on the virally encoded Rev trans activator. P
Identification of multirestricted immunodominant regions recognized by cytolytic T lymphocytes in the human immunodeficiency virus type 1 Nef protein [published erratum appears in J Virol 1995 Jan;69(1):618]: J Virol. 1994 Nov;68(11):7336-43. Unique Identifier : AIDSLINE MED/95018646; Culmann-Penciolelli B; Lamhamedi-Cherradi S; Couillin I; Guegan N; Levy JP; Guillet JG; Gomard E; Laboratoire d'Immunologie des Interactions Cellulaires et; Moleculaires, Institut National de la Sante et de la Recherche; Medicale U152. Institut Cochin de Genetique Moleculaire,; Paris, France.; Peripheral blood mononuclear cells from a large number of human immunodeficiency virus (HIV)-seropositive donors were used to analyze the CD8+ T-cell response to each part of the Nef protein of HIV-1/LAI. This report identifies an immunodominant region (amino acids 73 to 144) in the Nef protein that was recognized by
Risperidone in HIV-related manic psychosis [letter; comment]: Lancet. 1994 Oct 8;344(8928):1029-30. Unique Identifier : AIDSLINE MED/95020091; Singh AN; Catalan J
Quantitative analysis of RNA cleavage during RNA-directed DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases.: Nucleic Acids Res. 1994 Sep 11;22(18):3793-800. Unique Identifier : AIDSLINE MED/95023129; DeStefano JJ; Mallaber LM; Fay PJ; Bambara RA; Department of Microbiology, University of Maryland, College Park; 20742.; We have determined the extent of RNA cleavage carried out during DNA synthesis by either human immunodeficiency virus (HIV) or avian myeloblastosis virus (AMV) reverse transcriptases (RTs). Conditions were chosen that allowed the analysis of the cleavage and synthesis performed by the RT during one binding event on a
Extension of helix II of an HIV-1-directed hammerhead ribozyme with long antisense flanks does not alter kinetic parameters in vitro but causes loss of the inhibitory potential in living cells.: Nucleic Acids Res. 1994 Sep 25;22(19):3951-7. Unique Identifier : AIDSLINE MED/95023155; Homann M; Tabler M; Tzortzakaki S; Sczakiel G; Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches; Krebsforschungszentrum, Heidelberg, Germany.; When designed to cleave a target RNA in trans, the hammerhead ribozyme contains two antisense flanks which form helix I and helix III by pairing with the complementary target RNA. The sequences forming helix II are contained on the ribozyme strand and represent a major structural component of the hammerhead structure.
Solid phase assays for the detection of inhibitors of HIV reverse transcriptase.: Nucleic Acids Res. 1994 Sep 25;22(19):4018-9. Unique Identifier : AIDSLINE MED/95023165; Gause GG; Gonda MA; Laboratory of Cell and Molecular Structure, Program Resources,; Inc./DynCorp, National Cancer Institute-Frederick Cancer Research; and Development Center, MD 21702.
Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms.: Nucleic Acids Res. 1994 Oct 11;22(20):4307-14. Unique Identifier : AIDSLINE MED/95023205; Zelphati O; Imbach JL; Signoret N; Zon G; Rayner B; Leserman L; Centre d'Immunologie, Institut National de la Sante et de la; Recherche Medicale-Centre National de la Recherche Scientifique; de Marseille-Luminy Case 906, France.; Phosphodiester and phosphorothioate oligonucleotides in alpha and beta configurations directed against the initiation codon region of the HIV-1 rev gene were evaluated for their ability to inhibit HIV-1 replication in acutely and chronically infected human CEM cells. Encapsulation in antibody-targeted liposomes (immun
Utility of Gomori methenamine silver stains in bronchoalveolar lavage specimens.: Mod Pathol. 1994 Jun;7(5):599-604. Unique Identifier : AIDSLINE MED/95023863; Raab SS; Cheville JC; Bottles K; Cohen MB; Department of Pathology, University of Iowa, Iowa City.; Bronchoalveolar lavage (BAL) with Gomori methenamine silver (GMS) stain is commonly used to detect Pneumocystis carinii and fungal organisms as causes of infectious pulmonic disease in immunosuppressed patients. However, several reports have indicated that GMS stains are not any more sensitive than conventional cytolo
[A new bacterium: Rochalimaea]: Rev Prat. 1994 Apr 1;44(7):865-9. Unique Identifier : AIDSLINE MED/95025519; Maurin M; Stein A; Raoult D; Unite des rickettsies, CNRS EP J 0054, faculte de medecine,; Marseille.; Originally limited to trench fever, infections due to Rochalimaea now comprise manifestations particular to patients with human immunodeficiency virus ( bacillary angiomatosis and hepatic peliosis), but also manifestations as diverse as isolated fever, septicaemia, endocarditi
Expression of CD43 epitopes on NK and T cells.: Scand J Immunol. 1994 Oct;40(4):437-42. Unique Identifier : AIDSLINE MED/95025645; Hoysaeter S; Jensen W; Fossum S; Immunobiological Laboratory, Institute of Basic Medical Sciences,; University of Olso, Norway.; CD43 epitope expression was studied with a panel of monoclonal antibodies (MoAbs) by immunohistochemistry on freeze sections of lymphoid tissues. The MoAb WEN3 stained most cells weakly in the T areas and scattered splenic red pulp cells strongly, whereas the other MoAbs strongly stained the majority of the cells in t
Individual susceptibility to cyclosporine: possible involvement of the CD28/CD80 (B7/BB1) pathway.: Transplant Proc. 1994 Oct;26(5):2846-8. Unique Identifier : AIDSLINE MED/95027231; Masy E; Labalette-Houache M; Dessaint JP; Service d'Immunologie, Centre Hospitalier et Universitaire de; Lille, France.
HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes.: Virology. 1994 Nov 1;204(2):823-7. Unique Identifier : AIDSLINE MED/95027716; Maitra RK; McMillan NA; Desai S; McSwiggen J; Hovanessian AG; Sen G; Williams BR; Silverman RH; Department of Cancer Biology, Cleveland Clinic Foundation, Ohio; 44195.; The TAR sequence at the 5 -termini of all HIV-1 mRNA species forms a stable structure that is responsible for both transcriptional and translational regulation of HIV-1. Previously we and others reported that purified TAR RNA synthesized by in vitro transcription could activate two interferon-induced enzymes, the prot
[Rochalimaea henselae, Afipia felis and cat-scratch disease]: Acta Clin Belg. 1994;49(3-4):158-67. Unique Identifier : AIDSLINE MED/95028372; Thonnard J; Carreer FM; Delmee M; Universite Catholique de Louvain, Unite de Microbiologie,; Bruxelles.; Several years ago, Rochalimaea henselae has emerged as an agent of bacillary angiomatosis , bacillary peliosis and recurrent septicaemia that generally occur in patients infected with human immunodeficiency virus. An aetiologic role in cat scratch disease is also suspected wid
Th1-like cell responses to peripheral nerve myelin components over the course of experimental allergic neuritis in Lewis rats.: Acta Neurol Scand. 1994 Jul;90(1):19-25. Unique Identifier : AIDSLINE MED/95028405; Zhu J; Link H; Mix E; Olsson T; Huang WX; Department of Neurology, Karolinska Institute, Huddinge Hospital,; Stockholm, Sweden.; Experimental allergic neuritis (EAN) is a T cell-mediated animal model of Guillain-Barre syndrome characterized by inflammation and demyelination of peripheral nerves. EAN can be induced by immunization of rats with bovine peripheral nerve myelin (BPM) or the myelin proteins P2 or P0, but the extent of T cell response
S-adenosylmethionine levels in psychiatric and neurological disorders: a review.: Acta Neurol Scand Suppl. 1994;154:19-26. Unique Identifier : AIDSLINE MED/95028415; Bottiglieri T; Hyland K; Metabolic Disease Center, Baylor Research Institute, Dallas, TX; 75226.; INTRODUCTION--S-adenosylmethionine (SAMe) is an important methyl donor in over 35 methylation reactions involving DNA, proteins, phospholipids and catechol- and indole- amines. MATERIAL AND METHODS--This article reviews the studies that have examined brain and blood levels of SAMe in several psychological, neurologica
The effects of human recombinant MIP-1 alpha, MIP-1 beta, and RANTES on the chemotaxis and adhesion of T cell subsets.: Adv Exp Med Biol. 1993;351:139-46. Unique Identifier : AIDSLINE MED/95028773; Taub DD; Lloyd AR; Wang JM; Oppenheim JJ; Kelvin DJ; Laboratory of Molecular Immunoregulation, NCI-FCRDC, MD 21702.
The cleavage of the bait region of alpha 2-macroglobulin by human immunodeficiency virus proteinases and by astacin.: Ann N Y Acad Sci. 1994 Sep 10;737:431-3. Unique Identifier : AIDSLINE MED/95030789; Meier UC; Boetzel J; Kellermann J; Mann K; Billich A; Stocker W; Schramm HJ; Max-Planck-Institute for Biochemistry, Martinsried, Germany.
Enzymatic properties and sensitivity to inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with Glu-138-->Arg and Tyr-188-->His mutations.: Antiviral Res. 1994 May;24(1):43-57. Unique Identifier : AIDSLINE MED/95030978; Zhang H; Vrang L; Backbro K; Unge T; Noreen R; Oberg B; Medivir AB, Huddinge, Sweden.; Two mutants of HIV-1 reverse transcriptase (RT), Tyr-188-->His and Glu-138-->Arg have been prepared and their catalytic properties and sensitivities to inhibitors studied. As compared to wild type RT, a reduction in catalytic efficiency and turn over number was observed, especially for the Tyr-188-->His mutant. The no
Using Markov processes to describe the prognosis of HIV-1 infection.: Med Decis Making. 1994 Jul-Sep;14(3):266-72. Unique Identifier : AIDSLINE MED/95020416; Lu Y; Stitt FW; Department of Epidemiology and Public Health, University of Miami; School of Medicine, FL.; In 1989, Turner and colleagues proposed a new method for automated classification and prediction of outcomes for hospitalized patients with AIDS, based on severity of illness. The authors have confirmed this system, which includes three main stages and 20 substages, in a cohort of HIV-1-infected symptomatic patients a
In re application of Milton S. Hershey Medical Center.: Atlantic Reporter, 2d Series. 1993 Nov 4 (date of decision);634:159-163. Unique Identifier : AIDSLINE KIE/43452; The Supreme Court of Pennsylvania determined that a compelling need existed for partial disclosure of a physician s HIV-positive status. The decision affirmed two lower court holdings that permitted two Harrisburg hospitals to release information concerning the HIV status of a resident physician who had cut himself wi
Ethical pitfalls and benefits of disclosure of HIV-positive status.: Monagle, John F.; Thomasma, David C., eds. Health Care Ethics: Critical Issues. Gaithersburg, MD: Aspen Publishers, 1994 :188-198. Unique Identifier : AIDSLINE KIE/43717; Thomasma DC; Marshall P
How AIDS activists are changing research.: Monagle, John F.; Thomasma, David C., eds. Health Care Ethics: Critical Issues. Gaithersburg, MD: Aspen Publishers, 1994 :199-209. Unique Identifier : AIDSLINE KIE/43718; Kopelman LM
Doe v. City of New York.: Federal Reporter, 3d Series. 1994 Jan 28 (date of decision);15:264-270. Unique Identifier : AIDSLINE KIE/43807; The plaintiff, John Doe, together with other former Pan Am Airlines employees, interviewed for a position with Delta Airlines. When he was refused a job, Doe filed a complaint with New York City s human rights commission charging that Delta discriminated against him because he was a single gay male suspected of being
Consent evades consensus.: Hosp Ethics. 1994 Sep-Oct;10(5):5-6. Unique Identifier : AIDSLINE AHA/95001784; A problem area certain to become a tough nut to crack in years to come i