Effect of lignins on HIV-induced cytopathogenicity and on myeloperoxidase in human myelogenous leukemic cell lines (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Effect of lignins on HIV-induced cytopathogenicity and on myeloperoxidase in human myelogenous leukemic cell lines (Meeting abstract).

Molecular Biology of Hematopoiesis, 8th Symposium. July 9-13, 1993, Basel, Switzerland, p. 56, 1993.. Unique Identifier : AIDSLINE ICDB/95699339
Ushijima H; Kunisada T; Kitamura T; Rossol R; Muller WE; AIDS Res. Center, Natl. Inst. of Health, Tokyo 208, Japan

Abstract: Previously we reported that lignins display potent stimulatory effects on the iodination reaction in myeloperoxidase (MPO)-positive cells. We investigated the antihuman immunodeficiency virus (HIV) activity of lignins in MPO-positive (HL-60) and negative (U-937) human myelogenous leukemic cell lines. Natural lignified compounds and their dehydrogenated polymers effectively inhibit the cytopathic effect of HIV-1 infection in HL-60, U-937 cells, MT-4 and MOLT-4 cells. HIV infection results in a strong reduction of MPO activity in HL-60 cells, regardless of the presence or absence of lignins. From the experiments described, we conclude that the lignin-mediated anti-HIV activity is not correlated with the intracellular MPO activity, but has to be attributed to other mechanisms. One possibility might be a direct inactivation of HIV by lignins. Moreover, it appears to be plausible that the lignins display their anti-HIV activity by inhibiting the expression of virus genome, integrated into host DNA.
Keywords: *Cytopathogenic Effect, Viral/*DRUG EFFECTS Enzyme Induction Human HIV/*PATHOGENICITY Leukemia, Myeloid/ENZYMOLOGY/*MICROBIOLOGY Lignin/*PHARMACOLOGY Peroxidase/*BIOSYNTHESIS Tumor Cells, Cultured ABSTRACTKWDcytopathogeniceffect,viral/KWDdrugeffectsenzymeinductionhumanhiv/KWDpathogenicityleukemia,myeloid/enzymology/KWDmicrobiologylignin/KWDpharmacologyperoxidase/KWDbiosynthesistumorcells,culturedabstract
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M9521052

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