Cancer incidence in a population with high prevalence of HIV-1 infection (Meeting abstract).

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Cancer incidence in a population with high prevalence of HIV-1 infection (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 35:A1497 1994. Unique Identifier : AIDSLINE ICDB/95603183
Rabkin CS; Yellin F; Viral Epidemiology Branch, NCI, Bethesda, MD 20892

Abstract: To determine the types and rates of cancers occurring in excess in the presence of HIV-1 infection, we examined cancer registration data from San Francisco, California, for never-married men aged 25-54, of whom an estimated 20,000 (24%) were HIV-1 seropositive as of late 1984. Data from 1973-90 were used to calculate standardized incidence rates and ratios of observed to expected cancers, classified by site and by cell type. Kaposi's sarcoma incidence in never-married men plateaued in 1988-90 at 0.5% per year. Non-Hodgkin's lymphoma incidence increased 20-fold between 1973-79 and 1988-90; increases were most pronounced in tumors of higher grade histology and extranodal (especially CNS) primary sites. Hodgkin's disease incidence was 2.0 (95% confidence interval [CI], 1.3-3.0) times expected in 1988-90. Anal cancer incidence was 9.9 (95% CI, 4.5-19) times expected in 1973-79 and 10.1 (95% CI, 5.0-18) times expected in 1988-90. Ratios of observed to expected cancers of most other sites were 2.0 or less; the ratio for leiomyosarcomas (at any site) was 2.5 (95% CI, 0.5-7.4). As the HIV epidemic has progressed, the incidence of AIDS-related Kaposi's sarcoma has plateaued and non-Hodgkin's lymphoma has continued to rise. The effect on other tumors has been minor or absent. In particular, HIV is not related to the increased risk of anal cancer in homosexual men, which antedated the AIDS epidemic.

Keywords: Adult Anus Neoplasms/EPIDEMIOLOGY Brain Neoplasms/EPIDEMIOLOGY Cross-Sectional Studies Human HIV Infections/*EPIDEMIOLOGY *HIV-1 Incidence Lymphoma, AIDS-Related/EPIDEMIOLOGY Male Middle Age Neoplasms/*EPIDEMIOLOGY San Francisco/EPIDEMIOLOGY Sarcoma, Kaposi's/EPIDEMIOLOGY Skin Neoplasms/EPIDEMIOLOGY ABSTRACT
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M9521050

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