Deceptive imprinting in the immune response against HIV-1. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Deceptive imprinting in the immune response against HIV-1.

Immunol Today. 1994 Oct;15(10):475-8. Unique Identifier : AIDSLINE MED/95032554
Kohler H; Muller S; Nara PL; University of Kentucky Medical Center, Markey Cancer Center,; Lexington 40536.

Abstract: The clonal profile of anti-HIV-1 antibodies is established at the time of infection as part of a vigorous immune response against HIV-1, and remains stable during the infection process. This bias towards antibodies specific for the initially infecting clonal virus population, termed imprinting, is inappropriate for attempts of the infected host to control viral variants that subsequently emerge. Here, Heinz Kohler, Sybille Muller and Peter Nara argue that immunodominant epitopes on viral variants or recombinant proteins are selected that induce and maintain this deceptive state, and thereby remain unrecognized through a functional and cross-reactive hole in the B-cell repertoire.
Keywords: Animal Antibody Specificity Human HIV Antibodies/*IMMUNOLOGY HIV Infections/*IMMUNOLOGY HIV-1/*IMMUNOLOGY Immunodominant Epitopes/IMMUNOLOGY Lymphokines/IMMUNOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDanimalantibodyspecificityhumanhivantibodies/KWDimmunologyhivinfections/KWDimmunologyhiv-1/KWDimmunologyimmunodominantepitopes/immunologylymphokines/immunologyjournalarticlereviewreview,tutorial
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