Consequences of secondary or co-infections for immunity.

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Consequences of secondary or co-infections for immunity.

Curr Opin Immunol. 1994 Aug;6(4):539-44. Unique Identifier : AIDSLINE MED/95032853
Mosier DE; Department of Immunology, Scripps Research Institute, La Jolla,; California 92037.

Abstract: While remarkable progress has been made using genetically altered mice to understand the importance of different cytokines in protecting against experimental infections or co-infections, an examination of the opportunistic infections that occur during HIV infection of humans does not yet show a clear picture of cytokine imbalance. Opportunistic infections appear to result from impairments in cells mediating innate resistance, such as natural killer cells, macrophages, and neutrophils. Some of these defects may not be corrected even if CD4+ T cells were suddenly restored to normal. The lessons from immunodeficient and gene knockout mice now need to be put to the test in the clinic.

Keywords: Animal AIDS-Related Opportunistic Infections/*IMMUNOLOGY Cytokines/IMMUNOLOGY CD4-Positive T-Lymphocytes/IMMUNOLOGY Human HIV Infections/*IMMUNOLOGY Immunity Killer Cells, Natural/IMMUNOLOGY Mice JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
950228
M9521026

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