CD8+ T-cell memory to viruses. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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CD8+ T-cell memory to viruses.

Curr Opin Immunol. 1994 Aug;6(4):545-52. Unique Identifier : AIDSLINE MED/95032854
Doherty PC; Hou S; Tripp RA; St Jude Children's Research Hospital, Memphis, Tennessee; 38101-0318.

Abstract: Recent experiments show that laboratory mice infected once with an influenza A virus or with the murine parainfluenza type 1 virus, called the Sendai virus, have enhanced numbers of cytotoxic T-lymphocyte precursors ( > 20x background) for life. Neither virus persists at the genome level, and the mice are maintained under conditions where there is no possibility of re-infection. These observations are highly relevant to any understanding of CD8+ cell memory and suggest that the clonal burst size associated with the primary challenge is a key determining factor.
Keywords: Animal CD8-Positive T-Lymphocytes/*IMMUNOLOGY *Immunologic Memory Mice Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes, Cytotoxic/IMMUNOLOGY Virus Diseases/IMMUNOLOGY Viruses/*IMMUNOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDanimalcd8-positivet-lymphocytes/KWDimmunologyKWDimmunologicmemorymicesupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDt-lymphocytes,cytotoxic/immunologyvirusdiseases/immunologyviruses/KWDimmunologyjournalarticlereviewreview,tutorial
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M9521025

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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