Th1 versus Th2 responses in AIDS. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Th1 versus Th2 responses in AIDS.

Curr Opin Immunol. 1994 Aug;6(4):616-22. Unique Identifier : AIDSLINE MED/95032865
Romagnani S; Maggi E; Istituto di Clinica Medica 3, University of Florence, Italy.

Abstract: During the past two years, a simple theory that seeks to explain what causes the progression of HIV-infected individuals to AIDS has been gaining support. The theory holds that HIV-infected people switch from a T-helper type 1 (Th1) to a T-helper type 2 (Th2) state as the disease progresses. However the experimental data do not support the concept that a Th1/Th2 switch occurs in the majority of HIV-infected subjects, although it is conceivable that HIV-infected individuals who mount sustained and chronic Th2-type responses, as a result of allergic disorders and helminthic infestations, may undergo more active HIV replication and therefore progress faster to full-blown disease.
Keywords: Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Human HIV Infections/IMMUNOLOGY HIV-1/GROWTH & DEVELOPMENT Support, Non-U.S. Gov't Th1 Cells/*IMMUNOLOGY Th2 Cells/*IMMUNOLOGY Virus Replication JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDacquiredimmunodeficiencysyndrome/KWDimmunologyhumanhivinfections/immunologyhiv-1/growth&developmentsupport,non-uKWDsKWDgov'tth1cells/KWDimmunologyth2cells/KWDimmunologyvirusreplicationjournalarticlereviewreview,tutorial
950228
M9521021

Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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