Role of Bruton's tyrosine kinase in immunodeficiency. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Role of Bruton's tyrosine kinase in immunodeficiency.

Curr Opin Immunol. 1994 Aug;6(4):623-30. Unique Identifier : AIDSLINE MED/95032866
Tsukada S; Rawlings DJ; Witte ON; Department of Microbiology and Molecular Genetics, University of; California, Los Angeles 90024-1662.

Abstract: The genetic defect associated with human X-linked agammaglobulinemia and murine X-linked immunodeficiency was recently shown to result from lack of function of a new cytoplasmic tyrosine kinase, called Bruton's tyrosine kinase (Btk). The phenotypes associated with these immunodeficiencies indicate that Btk plays a critical role in B-lymphocyte development. The distinctive protein structure of Btk and preliminary functional studies suggest that Btk may act in a novel manner in a variety of signaling pathways.
Keywords: Agammaglobulinemia/*IMMUNOLOGY Animal B-Lymphocytes/IMMUNOLOGY Human Linkage (Genetics) Mice Murine Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Protein-Tyrosine Kinase/*PHYSIOLOGY Signal Transduction Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. X Chromosome JOURNAL ARTICLE REVIEW REVIEW, TUTORIALKWDagammaglobulinemia/KWDimmunologyanimalb-lymphocytes/immunologyhumanlinkage(genetics)micemurineacquiredimmunodeficiencysyndrome/KWDimmunologyprotein-tyrosinekinase/KWDphysiologysignaltransductionsupport,non-uKWDsKWDgov'tsupport,uKWDsKWDgov't,pKWDhKWDsKWDxchromosomejournalarticlereviewreview,tutorial
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Copyright © 1995 - National Library of Medicine. Reproduced under license with the National Library of Medicine, Bethesda, MD.

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