1995

The:end of the beginning. [videorecording]
Princeton, N.J. : Films for the Humanities and Sciences, c1993 1 videocassette (60 min.) : sd., col. ; 1/2 in (A time of AIDS) Unique Identifier : AIDSLINE AV/9440042
Barraclough J
(Producer) This program looks at the medical side of AIDS, focusing on the treatments available today and the hope for treatments to come. It profiles the AIDS pioneers, Drs. Fauci, Gallo, and Montagnier, and examines different theories about the two different strains of the virus.


The:HIV substance abuser. [videorecording]
[California] : Regents of the University of California, c1994 3 videocassettes (120 min.) : sd., col. ; 1/2 in. + 1 guide (30 p.) (The Haight-Ashbury training series ; v. 5) Unique Identifier : AIDSLINE AV/9439760
Cohen WE; Services
AIDS research : the story so far. [videorecording]
[Boston] : WGBH Educational Foundation, c1994 1 videocassette (57 min.) : sd., col. ; 1/2 in (The WGBH collection) Unique Identifier : AIDSLINE AV/9440035
Palfreman J
(Producer) In this report from the front lines of the war on AIDS, state-of-the-art computer animation reveals never-before-seen views of the AIDS virus at work, and top AIDS researchers explain how they are marshalling all their resources. Researchers have made some surprising discoveries along the way: people who a


Institute bimonthly AIDS science report. -15th report (Sept. 1988).
[Bethesda, Md.? : s.n., v Unique Identifier : AIDSLINE CAT/9423517
Third International Conference on AIDS and Associated Cancers in Africa : reported as the Second Workshop for the East, Central, and Southern Africa Commonwealth Health Community, held at the Arusha International Conference Centre, Arusha, Tanzania, September 14-16, 1988.
Arusha, Tanzania : Commonwealth Regional Health Community Secretariat, [1988?] 9 leaves Unique Identifier : AIDSLINE CAT/9436996
Institute AIDS science report. 16th (4th quarter 1988)-
[Bethesda, Md.? : s.n., 1988- v Unique Identifier : AIDSLINE CAT/9423516
National HIV serosurveillance summary : results through ... . 1990-
Atlanta, GA : U.S. Dept. of Health and Human Services, Public Health Service, Centers for Disease Control, [1991- v. : ill Unique Identifier : AIDSLINE CAT/9438799
[Sistema immunitari i SIDA.]
Valencia : Universitat de Valencia, Servei de Publicacions, 1990 181 p. : ill (Cultura universitaria popular ; 12) Unique Identifier : AIDSLINE CAT/9403819
Soler i Vazquez C
AIDS : a guide to survival. 3rd updated ed.
London : GMP Publishers, c1990 xvi, 157 p. : ill Unique Identifier : AIDSLINE CAT/9405027
Tatchell P
Looking after people with late HIV disease.
Newmill, Penzance, Cornwall : Patten Press in association with the Lisa Sainsbury Foundation, c1990 ix, 56 p (Lisa Sainsbury Foundation series) Unique Identifier : AIDSLINE CAT/9439909
Welch J; Newbury J
[La:seropositivite au quotidien.]
Paris : O. Jacob, c1991 190 p (La sante au quotidien ; 8) Unique Identifier : AIDSLINE CAT/9406889
Cassuto J
[AIDS e lavoro.] 1. ed.
Torino : Edizioni Gruppo Abele, [1991] 109, [62] p Unique Identifier : AIDSLINE CAT/9403789
Second STD HIV/AIDS Workshop for the Heads of the Pilot Schools.
[Manzini, Swaziland] : SHAPE Project, [1991] 36 leaves Unique Identifier : AIDSLINE CAT/9414799
Ntombela N
[Pharmacologie des analogues nucleosidiques utilises en therapeutique antiretrovirale.]
Paris : Arnette, c1991 102 p : ill Unique Identifier : AIDSLINE CAT/9407094
Pocidalo JJ
[SIDA.] [Ed. 1991]-
Paris : Doin, c1991- v. : ill Unique Identifier : AIDSLINE CAT/9432215
HIV prevention in Native American communities : a manual for Native American health and human service providers.
Oakland, CA : National Native American AIDS Prevention Center, c1992 144 p Unique Identifier : AIDSLINE CAT/9438879
Rush AG
HIV/AIDS prevention project for male sex workers in metro Manila : final report.
Quezon City : Health Action Information Network, 1992 1 v. (various pagings) : ill Unique Identifier : AIDSLINE CAT/9418175
Listening to Albertans at risk of HIV/AIDS : an assessment of risk reduction messages.
Edmonton, Alta. : Provincial AIDS Program, Alberta Health, [1992] x, 118 p. : ill Unique Identifier : AIDSLINE CAT/9438850
Programme and abstracts : venue, Kwacha Conference Centre, Blantyre, Malawi : date, 9th-12th March 1992.
[Malawi] : The Association, [1992?] 20 p Unique Identifier : AIDSLINE CAT/9436045
AIDS surveillance and education project : (492-0473) : project paper.
[Manila?] : USAID/Philippines, [1992] 1 v. (various pagins) : ill Unique Identifier : AIDSLINE CAT/9438853
AIDS prevention : the socio cultural context in India.
Bombay : Tata Institute of Social Sciences, c1992 xiv, 222 p Unique Identifier : AIDSLINE CAT/9421746
Mane PN; Maitra SA
AIDS, action now : information, prevention, and support in Zimbabwe. 2nd. rev. ed.
Harare, Zimbabwe : AIDS Counselling Trust : School of Social Work, 1992 xvii, 334 p. : ill Unique Identifier : AIDSLINE CAT/9421598
Jackson H
Coordination meeting of donor countries and agencies involved in the prevention and control of AIDS in the South Pacific : report : Suva, Fiji 24-26 August 1992.
Pacific Manila, Philippines : World Health Organization, Regional Office for the Western Pacific, [1992] 13 p Unique Identifier : AIDSLINE CAT/9409820
HIV/AIDS in Sweden : an analytical survey for the health and medical care services.
[Stockholm?] : National Board of Health and Welfare, [1992] 61 p. : ill Unique Identifier : AIDSLINE CAT/9442783
Malmquist H
Preventing AIDS in Malawi : a policy maker's information booklet.
[Lilongwe?] : Malawi Govt., Ministry of Health, [1992?] 16 p. : ill Unique Identifier : AIDSLINE CAT/9436035
[S.I.D.A., respuesta del naturismo.]
Buenos Aires : C.S. Ediciones, [1992] 288 p. : ill Unique Identifier : AIDSLINE CAT/9414809
Valles JM
[Sida, sociedad y derechos humanos.]
Madrid : Cruz Roja Espanola, Oficina Central, [1992?] 230 p. : ill (Coleccion Basica ; 13) Unique Identifier : AIDSLINE CAT/9414605
[Boses Blut : die Geschichte eines Medizin-Skandals.] 2. aktualiserte [sic] erw. Neuausg.
Hamburg : Hoffmann und Campe, 1993 336 p. : ill (Campe Paperback) Unique Identifier : AIDSLINE CAT/9432342
Koch ER
Political commitment in combating HIV/AIDS : second medium term plan, 1994-1998 : Zambia National AIDS/STD/TB & Leprosy Programme.
[Lusaka?] : The Ministry, [1993] 11 p Unique Identifier : AIDSLINE CAT/9439788
[Die:Stop AIDS-Story, 1987-1992.] 1. Aufl.
[Bern?] : STOP AIDS-Kampagne der AIDS-Hilfe Schweiz, 1993 117 p. : ill., port Unique Identifier : AIDSLINE CAT/9430953
Kocher KW
[Untersuchungen zur Expression und Funktionalitat der env-Glykoproteine von HIV-1 : Inaugural-Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultat der Heinrich-Heine-Universitat Dusseldorf.]
[Aachen : Verlag Shaker], 1993 xiv, 132 p. : ill (Reihe Medizin) Unique Identifier : AIDSLINE CAT/9420906
Klein M
AIDS and African development.
[Washington, D.C.? : Africa Region, the World Bank, 1993?] 14 p. : ill Unique Identifier : AIDSLINE CAT/9436734
AIDS funding : a guide to giving by foundations & charitable organizations. 3rd ed.
New York, NY : Foundation Center, c1993 xlviii, 196 p Unique Identifier : AIDSLINE CAT/9441380
Murphy CE
[Guide des therapies de l'infection VIH/SIDA : complications opportunistes, traitements anti-VIH, essais cliniques.]
sur le SIDA Quebec : [s.n., 1993?] iv, 147 p. : ill Unique Identifier : AIDSLINE CAT/9414045
[SIDA, juicio a un virus inocente.]
Madrid : Mandala, [1993?] 168 p. : ill Unique Identifier : AIDSLINE CAT/9436088
Costa Vercher E
An:epidemiological review of HIV/AIDS in Sub-Saharan Africa.
Washington, D.C. : Center for International Research, U.S. Bureau of the Census, [1994] ix, 53 p. : ill (CIR staff paper ; no. 72) Unique Identifier : AIDSLINE CAT/9435927
Way PO
Challenge and innovation : methodological advances in social research on HIV/AIDS.
London ; Bristol, PA : Taylor & Francis, 1994 xi, 264 p. : ill (Social aspects of AIDS) Unique Identifier : AIDSLINE CAT/9438859
Boulton M
Sexual politics in Cuba : machismo, homosexuality, and AIDS.
Boulder : Westview Press, 1994 xv, 184 p (Series in political economy and economic development in Latin America) Unique Identifier : AIDSLINE CAT/9432486
Leiner M
AIDS in India.
Jaipur : Rawat Publications, c1994 188 p Unique Identifier : AIDSLINE CAT/9439119
Thomas G
Infectious disease testing for blood transfusions : January 1975 through October 1994 : 1888 citations.
Bethesda, Md. (8600 Rockville Pike, Bethesda 20894) : U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine, Reference Section ; Pittsburgh, PA : Sold by the Supt. of Docs., U.S. G.P.O., 1994 ix, 81 p (Current bibliographies in medicine ; 94-10) Unique Identifier : AIDSLINE CAT/9500173
Glock M; McCurdy PR; for Blood Transfusions
Networking AIDS services.
Ann Arbor, Mich. : Health Administration Press, 1994 xvii, 238 p. : ill Unique Identifier : AIDSLINE CAT/9432996
Mor V
AIDSX. Vol. 1, no. 1 (May 1994)-
Darlinghurst, NSW : AIDSX, 1994- v Unique Identifier : AIDSLINE CAT/9434445
[Pflege bei Haut- und Geschlechtskrankheiten.]
Wien ; New York : Springer-Verlag, c1994 xi, 119 p. : ill Unique Identifier : AIDSLINE CAT/9432385
Deutschmann G
Report of a meeting on the development of vaginal microbicides for the prevention of heterosexual transmission of HIV, Geneva, 11-13 November 1993.
[Geneva?] : World Health Organization, c1994 24 p Unique Identifier : AIDSLINE CAT/9441423
AIDS and Chinese medicine.
New Canaan, Conn. : Keats Pub. ; Long Beach, Calif. : Oriental Healing Arts Institute, 1995 Unique Identifier : AIDSLINE CAT/9500596
Zhang Q; Hsu H
Renal and urologic aspects of HIV infection.
New York : Churchill Livingstone, 1995 xvi, 427 p. : ill (Contemporary issues in nephrology ; v. 29) Unique Identifier : AIDSLINE CAT/9501177
Kimmel PL; Berns JS
Advances in adult T-cell leukemia and HTLV-I research.
Gann Monogr Cancer Res; 39:1-261 1992. 1992. Unique Identifier : AIDSLINE ICDB/95606768
Takatsuki K; Hinuma Y; Yoshida M; No affiliation given
This volume represents a 10-year update to one published in 1982 in the same series. HTLV-I is now recognized as a causative agent of adult T-cell leukemia (ATL) and also of a neurologic disease, HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Japanese workers have been particularly active in this


Biological features of the HTLV-Ip12I protein and its possible role in HTLV-I pathogenesis (Meeting abstract).
Molecular Biology of Hematopoiesis, 8th Symposium. July 9-13, 1993, Basel, Switzerland, p. 44, 1993.. Unique Identifier : AIDSLINE ICDB/95699329
Franchini G; Mulloy J; Koralnik I; Boeri E; Lomonico A; Schlegel R; Leonard W; Gallo RC; Lab. of Tumor Cell Biology, NCI, Bethesda, MD 20892
HTLV-I induces T-cell leukemia and transforms human T-cells in vitro. The p12I protein, encoded by the HTLV-I pX region, exhibits significant amino acid sequence similarity to the E5 oncoprotein of bovine papillomavirus (BPV)-1. The p12I protein cooperates with the BPV-1 E5 oncoprotein in neoplastic transformation in


Epstein-Barr virus DNA and latent gene products in Hodgkin's disease and non-Hodgkin's lymphomas (Meeting abstract).
Molecular Biology of Hematopoiesis, 8th Symposium. July 9-13, 1993, Basel, Switzerland, p. 55, 1993.. Unique Identifier : AIDSLINE ICDB/95699338
Herbst H; Steinbrecher E; Dallenbach F; Niedobitek G; Young LS; Muller-Lantzsch N; Stein H; Inst. of Pathology, Klinikum Steglitz, Free Univ. Berlin, Germany
In recent years, techniques, probes and reagents became available to reliably visualize EBV-infected cells, to assess EBV gene expression, and to characterize the clonal composition of EBV genomes in human tissues. Application of these techniques to lymphoproliferative lesions revealed (1) an association of EBV with v


Effect of lignins on HIV-induced cytopathogenicity and on myeloperoxidase in human myelogenous leukemic cell lines (Meeting abstract).
Molecular Biology of Hematopoiesis, 8th Symposium. July 9-13, 1993, Basel, Switzerland, p. 56, 1993.. Unique Identifier : AIDSLINE ICDB/95699339
Ushijima H; Kunisada T; Kitamura T; Rossol R; Muller WE; AIDS Res. Center, Natl. Inst. of Health, Tokyo 208, Japan
Previously we reported that lignins display potent stimulatory effects on the iodination reaction in myeloperoxidase (MPO)-positive cells. We investigated the antihuman immunodeficiency virus (HIV) activity of lignins in MPO-positive (HL-60) and negative (U-937) human myelogenous leukemic cell lines. Natural lignified


Biological activity of thymopentin in cutaneous T-cell lymphoma (Meeting abstract).
Proc Annu Meet Am Assoc Cancer Res; 35:A1416 1994. Unique Identifier : AIDSLINE ICDB/95603102
Foss F; Sznol M; Urba W; Kopp W; Duffy P; McCaffrey R; Hesketh P; Longo D; Section of Medical Oncology, Boston University Medical Center,; Boston MA 02118
Thymopentin (TP5), a synthetic pentapeptide corresponding to the active site of the human thymic hormone, thymopoietin, has demonstrated immunomodulatory activity in autoimmune diseases, immune deficiencies, and HIV infection. A recent study reported a 75% response rate to TP5 in patients with the Sezary syndrome who


Cancer incidence in a population with high prevalence of HIV-1 infection (Meeting abstract).
Proc Annu Meet Am Assoc Cancer Res; 35:A1497 1994. Unique Identifier : AIDSLINE ICDB/95603183
Rabkin CS; Yellin F; Viral Epidemiology Branch, NCI, Bethesda, MD 20892
To determine the types and rates of cancers occurring in excess in the presence of HIV-1 infection, we examined cancer registration data from San Francisco, California, for never-married men aged 25-54, of whom an estimated 20,000 (24%) were HIV-1 seropositive as of late 1984. Data from 1973-90 were used to calculate


Comparative anabolism of azidothymidine (AZT) and didanosine (ddI) in human T-cell lines sensitive and resistant to AZT and human PBMC cells (Meeting abstract).
Proc Annu Meet Am Assoc Cancer Res; 35:A1982 1994. Unique Identifier : AIDSLINE ICDB/95603668
Periclou AP; Solorzano MM; Avramis VI; Division of Hem./Onc, USC/Childrens Hospital Los Angeles, Los; Angeles, CA 90027
We have investigated the drug synergism between AZT and ddI in PBMC cells from pediatric patients with HIV-1 infection ex vivo and in T-cells in vitro. We investigated whether the drug anabolites, AZTTP and ddATP, could act synergistically intracellul


Overcoming drug/cytokine resistance of AIDS-associated NHL cells following treatment with IFN-gamma in vitro (Meeting abstract).
Proc Annu Meet Am Assoc Cancer Res; 35:A2001 1994. Unique Identifier : AIDSLINE ICDB/95603687
Demidem A; Salahuddin Z; Lam T; Nakamura S; Levine A; Khan RS; Jewett A; Bonavida B; University of California, Los Angeles, CA 90024
Non-Hodgkin s B Lymphomas (NHL) progressively become resistant to conventional chemotherapy. Several new approaches were undertaken to test reversal of resistance of NHL. We have developed B cell lines from the tumor biopsies of AIDS patients with NHL. The NHL cell lines were shown to be resistant to a panel of cytoki


A novel zidovudine-uridine dimer as an anti-HIV agent with increased therapeutic index (Meeting abstract).
Proc Annu Meet Am Assoc Cancer Res; 35:A2011 1994. Unique Identifier : AIDSLINE ICDB/95603697
Lu Q; Gogu SR; Bandara N; Rider B; Garry RF; Agrawal KC; Dept. of Pharmacology, Tulane Univ. Sch. of Medicine, New; Orleans, LA 70112
Zidovudine ( AZT )-induced hematopoietic toxicity remains a major limiting factor in the clinical management of AIDS. Since uridine has been shown to protect the bone marrow cells (BMC) from AZT toxicity, we have synthesized a novel phosphate diester of


A 3D-QSAR study of HIV integrase inhibitors (Meeting abstract).
Proc Annu Meet Am Assoc Cancer Res; 35:A2015 1994. Unique Identifier : AIDSLINE ICDB/95603701
Raghavan K; Buolamwini JK; Myers T; Zaharevitz DW; Paull KD; Fesen M; Mazumder A; Pommier Y; Kohn KW; Grever MR; et al; Developmental Therapeutics Program, Div. of Cancer Treatment,; NCI, Bethesda, MD 20892
Using the comparative molecular field analysis technique, we have studied a set of flavone analogs that inhibit HIV-1 integrase-mediated cleavage and integration in vitro. The results indicate a correlation between the inhibitory activity of these flavones and the steric and electrostatic fields around them. The 3D-QS


Analytical studies and murine pharmacokinetics of cosalane (Meeting abstract).
Proc Annu Meet Am Assoc Cancer Res; 35:A2546 1994. Unique Identifier : AIDSLINE ICDB/95604231
Bigelow J; Mathews L; Chrin L; Horton P; McCormack J; Vermont Cancer Center and Dept. of Pharmacology, Univ. of; Vermont, Burlington, Vermont 05405
Cosalane (NSC 640067; COS) is a steroid derivative that contains two aryl carboxylate functions, and exhibits anti-HIV activity apparently by inhibition of viral attachment to target cells. We have developed an assay that is suitable for detection and determination of COS in biological fluids. Samples are prepared for


Recombinant granulocyte growth factors in the management of HIV-related neoplasms: personal experience (Meeting abstract).
Molecular Biology of Hematopoiesis, 8th Symposium. July 9-13, 1993, Basel, Switzerland, p. 60, 1993.. Unique Identifier : AIDSLINE ICDB/95699340
Torresin A; Guida B; Crisalli MP; Piersantelli N; Infectious Diseases Dept., Galliera Hosp., Genoa, Italy
The aim of our study was to assess the role for recombinant granulocyte growth factors (rG-CSF) in the management of HIV-related malignancies. We treated with chemo and/or radiotherapy 6 patients, all males, mean age 35 years, HIV infected, belonging in the IV class of CDC staging classification, for the following neo


[Why is AIDS spreading so fast in Africa? (letter)]
Duodecim. 1991;107(2):126. Unique Identifier : AIDSLINE MED/95045043
Siirala M
[Radiologic manifestation of AIDS in disorders of thoracic and abdominal organs]
Vestn Rentgenol Radiol. 1991 May-Jun;(3):18-33. Unique Identifier : AIDSLINE MED/95065595
Epshtein DM; Grumbakh K
[Radiologic pulmonary manifestations in patients with HIV virus infection]
Vestn Rentgenol Radiol. 1991 May-Jun;(3):34-9. Unique Identifier : AIDSLINE MED/95065596
Meleshenkov BA; Trutnev PV; Hdaisaba V
Altogether 155 patients with a newly detected positive reaction to HIV (a human immunodeficiency virus) were investigated in the Republic of Burundi . Chest x-ray was done in 80 of them. Pulmonary tuberculosis was diagnosed in 2 of them, pneumonia (chronic, interstitial and bronchi


Hepatitis B virus [letter; comment]
AAOHN J. 1994 Aug;42(8):361. Unique Identifier : AIDSLINE MED/95032336
Sudden appearance of multiple brain lesions in Aids after a cerebral biopsy. Case report.
Bol Asoc Med P R. 1994 Jul-Sep;86(7-9):46-9. Unique Identifier : AIDSLINE MED/95032416
De Jesus O; Inserni J; Acebal P; Rifkinson N; Pacheco H; Section of Neurosurgery, University of Puerto Rico, San Juan; 00936.
A unique case of cerebral toxoplasmosis which had an acute appearance of multiple discrete lesions following a biopsy and its neuroradiological findings are reported in detail. Possible pathophysiological mechanism are presented.


Cytomegalovirus retinitis in AIDS patients: a clinical review.
Bol Asoc Med P R. 1994 Jul-Sep;86(7-9):62-7. Unique Identifier : AIDSLINE MED/95032420
Vendrell CP; Ramirez-Ronda CH; Infectious Diseases Program, University of Puerto Rico School of; Medicine, San Juan.
Cytomegalovirus ( CMV ) retinitis is an ocular condition previously seen in organ transplant recipients, patient on chemotherapy for malignancy, and in infants with congenital infections. As it present in immunocompromised, the AIDS patient has integrated this gro


Synthesis and in vitro anti-HIV activity of novel delta 2-1,2,4-oxadiazoline derivatives.
Farmaco. 1994 Jul-Aug;49(7-8):509-11. Unique Identifier : AIDSLINE MED/95032500
Chimirri A; Grasso S; Monforte AM; Monforte P; Zappala M; Carotti A; Dipartimento Farmaco-Chimico, Universita di Messina, Italy.
The synthesis of 4-adamantyl-5-aryl-3-phenyl-delta 2-1,2,4-oxadiazolines, involving an 1,3-dipolar cycloaddition reaction between 1-[(arylidene)amino]adamantanes and benzonitriloxide, is described. The evaluation of in vitro antiviral activity against human immunodeficiency virus (HIV) of the compounds obtained is als


Neuroleptic treatment of HIV-associated psychosis. HNRC group.
Neuropsychopharmacology. 1994 Jul;10(4):223-9. Unique Identifier : AIDSLINE MED/95032514
Sewell DD; Jeste DV; McAdams LA; Bailey A; Harris MJ; Atkinson JH; Chandler JL; McCutchan JA; Grant I; University of California, San Diego.
The aim of this rater-blinded randomized study was to evaluate the efficacy and side effects of haloperidol and thioridazine in the treatment of new-onset psychosis in HIV-positive individuals. Participants were 13 men who had no history of psychosis prior to infection with HIV, and whose psychosis was not attributabl


Tuberculosis crisis [news]
World Health Forum. 1994;15(3):292-3. Unique Identifier : AIDSLINE MED/95032545
Maternal and child health and AIDS [news]
World Health Forum. 1994;15(3):295-6. Unique Identifier : AIDSLINE MED/95032546
The role of interleukin 12 in the immune response, disease and therapy [see comments]
Immunol Today. 1994 Oct;15(10):460-3. Unique Identifier : AIDSLINE MED/95032551
Trinchieri G; Scott P; Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.
Deceptive imprinting in the immune response against HIV-1.
Immunol Today. 1994 Oct;15(10):475-8. Unique Identifier : AIDSLINE MED/95032554
Kohler H; Muller S; Nara PL; University of Kentucky Medical Center, Markey Cancer Center,; Lexington 40536.
The clonal profile of anti-HIV-1 antibodies is established at the time of infection as part of a vigorous immune response against HIV-1, and remains stable during the infection process. This bias towards antibodies specific for the initially infecting clonal virus population, termed imprinting, is inappropriate for at


Apoptosis, anti-apoptotic compounds and TNF-alpha release [letter; comment]
Immunol Today. 1994 Oct;15(10):495-6. Unique Identifier : AIDSLINE MED/95032558
Famularo G; De Simone C; Tzantzoglou S; Trinchieri V
HIV-1 infection and eosinophilia [letter]
Immunol Today. 1994 Oct;15(10):498-9. Unique Identifier : AIDSLINE MED/95032561
Caterino-de-Araujo A
Specific inhibition of a human papillomavirus E2 trans-activator by intracellular delivery of its repressor.
DNA Cell Biol. 1994 Oct;13(10):1011-9. Unique Identifier : AIDSLINE MED/95032731
Pepinsky RB; Androphy EJ; Corina K; Brown R; Barsoum J; Biogen, Inc., Cambridge, MA 02142.
Papillomaviruses are the causative agents of benign and malignant epithelial tumors of the skin and mucosa. They encode a DNA-binding protein, E2, that regulates viral transcription and replication, making it an important therapeutic target. By deleting the amino-terminal trans-activation domain of human papillomaviru


Stereotaxic brain biopsy in AIDS patients: does it contribute to patient management?
Br J Neurosurg. 1994;8(3):307-11. Unique Identifier : AIDSLINE MED/95032832
Viswanathan R; Ironside J; Bell JE; Brettle RP; Whittle IR; Department of Clinical Neurosciences, Western General Hospital,; Edinburgh, UK.
The authors analysed all cases of brain biopsy done in AIDS or HIV+patients at the Department of Clinical Neurosciences, Western General Hospital, Edinburgh, during the period 1989-92 to determine the clinical utility of the procedure. Thirteen lesions were biopsied revealing toxoplasmosis in five, lymphoma in four, p


Bacterial and protozoal infections in genetically disrupted mice.
Curr Opin Immunol. 1994 Aug;6(4):518-25. Unique Identifier : AIDSLINE MED/95032850
Kaufmann SH; Department of Immunology, University of Ulm, Germany.
Immune gene knock-out mice have provided challenging new opportunities for scientists interested in infection and immunity. This novel experimental approach has made it possible to gain deeper insights into the mechanisms that are operative in defence against, and the pathology of, infectious disease. It has allowed t


Consequences of secondary or co-infections for immunity.
Curr Opin Immunol. 1994 Aug;6(4):539-44. Unique Identifier : AIDSLINE MED/95032853
Mosier DE; Department of Immunology, Scripps Research Institute, La Jolla,; California 92037.
While remarkable progress has been made using genetically altered mice to understand the importance of different cytokines in protecting against experimental infections or co-infections, an examination of the opportunistic infections that occur during HIV infection of humans does not yet show a clear picture of cytoki


CD8+ T-cell memory to viruses.
Curr Opin Immunol. 1994 Aug;6(4):545-52. Unique Identifier : AIDSLINE MED/95032854
Doherty PC; Hou S; Tripp RA; St Jude Children's Research Hospital, Memphis, Tennessee; 38101-0318.
Recent experiments show that laboratory mice infected once with an influenza A virus or with the murine parainfluenza type 1 virus, called the Sendai virus, have enhanced numbers of cytotoxic T-lymphocyte precursors ( > 20x background) for life. Neither virus persists at the genome level, and the mice are maintained u


Mucosal immunity to infection with implications for vaccine development.
Curr Opin Immunol. 1994 Aug;6(4):572-83. Unique Identifier : AIDSLINE MED/95032859
Staats HF; Jackson RJ; Marinaro M; Takahashi I; Kiyono H; McGhee JR; Department of Microbiology, University of Alabama at Birmingham; 35294-2170.
The induction of effective mucosal immunity that also provides systemic immunity is a considerable challenge. Over the past two years, efforts to develop novel mucosal vaccine delivery systems to induce mucosal immunity against bacterial and viral diseases, including HIV, have dramatically increased. Here we cite nove


Tracking HIV during disease progression.
Curr Opin Immunol. 1994 Aug;6(4):600-4. Unique Identifier : AIDSLINE MED/95032863
Pantaleo G; Fauci AS; Laboratory of Immunoregulation, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.
Several recent advances have been made in the delineation of the multiple pathogenic mechanisms involved in the progression of HIV disease. Included among these are the virological and immunological events associated with primary infection and the delineation of the role of lymphoid organs.


Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells?
Curr Opin Immunol. 1994 Aug;6(4):605-15. Unique Identifier : AIDSLINE MED/95032864
Finkel TH; Banda NK; Department of Pediatrics, National Jewish Center for Immunology; and Respiratory Medicine, Denver, Colorado 80206.
Although twelve years have passed since the identification of HIV as the cause of AIDS, we do not yet know how HIV kills its target, the CD4+ T cell, nor how this killing cripples the immune system. Prominent theories include direct killing of infected CD4+ T cells by the action or accumulation of cytopathic viral DNA


Th1 versus Th2 responses in AIDS.
Curr Opin Immunol. 1994 Aug;6(4):616-22. Unique Identifier : AIDSLINE MED/95032865
Romagnani S; Maggi E; Istituto di Clinica Medica 3, University of Florence, Italy.
During the past two years, a simple theory that seeks to explain what causes the progression of HIV-infected individuals to AIDS has been gaining support. The theory holds that HIV-infected people switch from a T-helper type 1 (Th1) to a T-helper type 2 (Th2) state as the disease progresses. However the experimental d


Role of Bruton's tyrosine kinase in immunodeficiency.
Curr Opin Immunol. 1994 Aug;6(4):623-30. Unique Identifier : AIDSLINE MED/95032866
Tsukada S; Rawlings DJ; Witte ON; Department of Microbiology and Molecular Genetics, University of; California, Los Angeles 90024-1662.
The genetic defect associated with human X-linked agammaglobulinemia and murine X-linked immunodeficiency was recently shown to result from lack of function of a new cytoplasmic tyrosine kinase, called Bruton s tyrosine kinase (Btk). The phenotypes associated with these immunodeficiencies indicate that Btk plays a cri


Experience from HIV incidence cohorts in Thailand: implications for HIV vaccine efficacy trials [editorial; comment]
AIDS. 1994 Jul;8(7):1007-10. Unique Identifier : AIDSLINE MED/95032904
Weniger BG
Low level of cell-free virus detected at high frequency in saliva from HIV-1-infected individuals [letter]
AIDS. 1994 Jul;8(7):1011-2. Unique Identifier : AIDSLINE MED/95032905
Phillips J; Qureshi N; Barr C; Henrard DR
Further evidence of the presence of genetically aberrant HIV-1 strains in Cameroon and Gabon [letter]
AIDS. 1994 Jul;8(7):1012-3. Unique Identifier : AIDSLINE GENBANK/X78477
Janssens W; Nkengasong JN; Heyndrickx L; Fransen K; Ndumbe PM; Delaporte E; Peeters M; Perret JL; Ndoumou A; Atende C; et al
Resolution of oral hairy leukoplakia during treatment with foscarnet [letter]
AIDS. 1994 Jul;8(7):1014-6. Unique Identifier : AIDSLINE MED/95032908
Albrecht H; Stellbrink HJ; Brewster D; Greten H
HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro [letter]
AIDS. 1994 Jul;8(7):1016-7. Unique Identifier : AIDSLINE MED/95032909
Hofmann B; Nishanian P; Fan J; Nguyen T; Fahey JL
Anticardiolipin antibody and stroke in an HIV-positive patient [letter]
AIDS. 1994 Jul;8(7):1019-20. Unique Identifier : AIDSLINE MED/95032911
Thirumalai S; Kirshner HS
HIV seroprevalence rates in Benin [letter; comment]
AIDS. 1994 Jul;8(7):1021-2. Unique Identifier : AIDSLINE MED/95032913
Adjovi C; Josse R; Foundohou J; Helynck B; Davo N
Failure of cytarabine and increased JC virus-DNA burden in the cerebrospinal fluid of patients with AIDS-related progressive multifocal leucoencephalopathy [letter]
AIDS. 1994 Jul;8(7):1022-4. Unique Identifier : AIDSLINE MED/95032914
Antinori A; De Luca A; Ammassari A; Cingolani A; Murri R; Colosimo G; Roselli R; Scerrati M; Tamburrini E
Contraceptives and HIV [editorial]
AIDS. 1994 Jul;8(7):861-71. Unique Identifier : AIDSLINE MED/95032915
Howe JE; Minkoff HL; Duerr AC
Evaluation of in vivo and in vitro interactions of feline immunodeficiency virus and feline leukemia virus.
AIDS. 1994 Jul;8(7):873-8. Unique Identifier : AIDSLINE MED/95032916
Beebe AM; Faith TG; Sparger EE; Torten M; Pedersen NC; Dandekar S; Department of Internal Medicine, School of Medicine, University; of California, Davis 95616.
OBJECTIVE: To determine the potential mechanisms for disease potentiation where feline immunodeficiency virus (FIV) infection of persistently feline leukemia virus (FeLV)-infected cats results in more severe FIV disease and increased mortality than FIV infection of specific pathogen-free cats. DESIGN AND METHODS: To d


Comparison of plasma cytokine levels in African patients with HIV-1 and HIV-2 infection.
AIDS. 1994 Jul;8(7):879-84. Unique Identifier : AIDSLINE MED/95032917
Chollet-Martin S; Simon F; Matheron S; Joseph CA; Elbim C; Gougerot-Pocidalo MA; INSERM U294, Department of Immunology and Biological Haematology,; CHU Bichat-Claude Bernard, Paris, France.
OBJECTIVE: To determine plasma cytokine levels [tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6] in African patients infected with HIV-2 relative to values in HIV-1-infected patients, and their relation to immunologic and clinical status. DESIGN: Questions about the observed differences in the path


Saliva-based HIV-antibody testing in Thailand.
AIDS. 1994 Jul;8(7):885-94. Unique Identifier : AIDSLINE MED/95032918
Frerichs RR; Silarug N; Eskes N; Pagcharoenpol P; Rodklai A; Thangsupachai S; Wongba C; Department of Epidemiology, UCLA 90024-1772.
OBJECTIVE: To determine whether saliva could serve as an alternative to serum for HIV-antibody testing in an ongoing sentinel surveillance program in Thailand . METHODS: Serum and saliva specimens were collected from 1955 individuals in four of the 73 sentinel sites of the nationa


Quantitation of HIV-1 in whole blood of infected children.
AIDS. 1994 Jul;8(7):895-900. Unique Identifier : AIDSLINE MED/95032919
Alimenti A; Luzuriaga K; Sullivan JL; Van den Borre C; Zissis G; Levy J; Department of Paediatrics and Microbiology, Hopital; Universitaire Saint-Pierre, Brussels, Belgium.
OBJECTIVE: To validate the technique of HIV-1 culture from whole blood for the quantitation of viral load in infected children. PATIENTS: Forty-three HIV-1-infected children were followed in two paediatric centres. METHODS: Quantitative HIV-1 cultures from unfractionated whole blood using an end-point dilution techniq


Comparison of in vivo plasma and peripheral blood mononuclear cell HIV-1 quasi-species to short-term tissue culture isolates: an analysis of tat and C2-V3 env regions.
AIDS. 1994 Jul;8(7):901-9. Unique Identifier : AIDSLINE GENBANK/U00272
Sabino E; Pan LZ; Cheng-Mayer C; Mayer A; Irwin Memorial Blood Centers, San Francisco, CA 94118.
OBJECTIVE: To determine whether the HIV-1 genomes that grow out in vitro from peripheral blood mononuclear cells (PBMC) better represent the in vivo quasi-species present in plasma or PBMC. RESULTS: For one patient (9606), PBMC culture represented more accurately the plasma rather than the in vivo PBMC quasi-species d


Immunologic markers of AIDS progression: consistency across five HIV-infected cohorts. Multicohort Analysis Project Workshop. Part I.
AIDS. 1994 Jul;8(7):911-21. Unique Identifier : AIDSLINE MED/95032921
OBJECTIVE: To provide background on five HIV-infected cohorts with documented seroconversion times and serum immunoglobulin (Ig) A and beta 2-microglobulin (beta 2M), CD4+ cell count and haemoglobin levels. To give a relative risks (RR) regression summary of the prognostic value of serial CD4+ cell count, IgA, beta 2M


Immunologic marker paths for seroconversion: single determinations of immunoglobulin A and beta 2-microglobulin are not adequate to estimate time of HIV infection. Multicohort Analysis Project Workshop. Part II.
AIDS. 1994 Jul;8(7):923-33. Unique Identifier : AIDSLINE MED/95032922
OBJECTIVE: To investigate the usefulness of single determinations of serum immunoglobulin (Ig) A and beta 2-microglobulin (beta 2M) levels in estimating the time from HIV seroconversion. SUBJECTS: Five cohorts were represented in the workshop. The Multicohort Analysis Project (MAP) workshop database comprised 1744 HIV


Aerosolized pentamidine as primary prophylaxis for Pneumocystis carinii pneumonia: efficacy, mortality and morbidity [see comments]
AIDS. 1994 Jul;8(7):935-9. Unique Identifier : AIDSLINE MED/95032923
Lidman C; Berglund O; Tynell E; Lindback S; Elvin K; Department of Infectious Diseases, Huddinge Hospital, Sweden.
OBJECTIVE: Primary prophylaxis against Pneumocystis carinii pneumonia (PCP) for patients with HIV infection has been recommended by the Centers for Disease Control and Prevention. We evaluated alternatives to routine primary PCP prophylaxis with aerosolized pentamidine. METHODS: A total of 121 HIV-infected patients wi


Pneumococcal and influenza vaccination levels among HIV-infected adolescents and adults receiving medical care in the United States. Adult and Adolescent Spectrum of HIV Disease Project Group.
AIDS. 1994 Jul;8(7):941-4. Unique Identifier : AIDSLINE MED/95032924
Wortley PM; Farizo KM; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, Georgia 30333.
OBJECTIVE: To assess pneumococcal and influenza vaccination coverage among HIV-infected adolescents and adults receiving medical care in the United States . DESIGN: Periodic medical record reviews. SETTING: More than 90 clinics, hospitals, and private medical practices in nine cities. P


Cross-sectional study of the susceptibility of Candida isolates to antifungal drugs and in vitro-in vivo correlation in HIV-infected patients [see comments]
AIDS. 1994 Jul;8(7):945-50. Unique Identifier : AIDSLINE MED/95032925
Chavanet P; Lopez J; Grappin M; Bonnin A; Duong M; Waldner A; Buisson M; Camerlynck P; Portier H; Department of Tropical and Infectious Diseases, Bocage Hospital,; Dijon, France.
OBJECTIVES: To investigate (1) the frequency of clinical resistance to oral polyenes or azole treatment for oral candidiasis, (2) the frequency of resistant in vitro Candida strains, (3) the relationship between the susceptibilities of in vitro Candida species and in vivo status in HIV patients. DESIGN: Prospective cr


The incidence of HIV-1 infections in village populations of northern Thailand [see comments]
AIDS. 1994 Jul;8(7):951-5. Unique Identifier : AIDSLINE MED/95032926
Nelson KE; Suriyanon V; Taylor E; Wongchak T; Kingkeow C; Srirak N; Lertsrimongkol C; Cheewawat W; Celentano D; Department of Epidemiology, Johns Hopkins University, School of; Hygiene and Public Health, Baltimore, MD 21205.
OBJECTIVES: To determine the age- and sex-specific prevalence of HIV-1 infection in a general ambulatory population in northern Thailand in 1990 and 1992, and the incidence of HIV-1 infections between 1990 and 1992. DESIGN: Health fairs were held in five villages in Chiang Mai pr


HIV-1 seroprevalence in chest clinic and hospital tuberculosis patients in New York City, 1989-1991.
AIDS. 1994 Jul;8(7):957-62. Unique Identifier : AIDSLINE MED/95032927
Greenberg BL; Weisfuse IB; Makki H; Adler J; el-Sadr W; Clarke L; Gainey S; Alford T; McFarlane K; Thomas PA; Office of HIV Serosurveys/AIDS Research, New York City Department; of Health, Bronx.
OBJECTIVE: To describe more fully HIV-1 and tuberculosis (TB) coinfection in TB patients attending New York City Department of Health chest clinics (1989-1991) and one inner-city hospital (1990-1991). DESIGN: An unlinked serosurvey using HIV-1-antibody testing of remnant blood specimens collected for routine medical p


Beta 2-microglobulin as a predictor of death in HIV-infected women from Kigali, Rwanda.
AIDS. 1994 Jul;8(7):963-9. Unique Identifier : AIDSLINE MED/95032928
Kerlikowske KM; Katz MH; Allen S; Wolf W; Hudes ES; Karita E; Serufilira A; Van de Perre P; General Internal Medicine Section, Department of Veterans; Affairs, San Francisco, California.
OBJECTIVE: To determine if beta 2-microglobulin (beta 2M) predicts death among HIV-infected African women. DESIGN: Nested case-control study. SETTING: Kigali, Rwanda . PARTICIPANTS: Two hundred and five seroprevalent women known to be HIV-infected since 1986-1987; 67 of whom died of


Prevalence of HIV-1 infection in rural, semi-urban and urban villages in southwest Tanzania: estimates from a blood-donor study.
AIDS. 1994 Jul;8(7):971-6. Unique Identifier : AIDSLINE MED/95032929
Soderberg S; Temihango W; Kadete C; Ekstedt B; Masawe A; Vahlne A; Horal P; Department of Internal Medicine, University Hospital, Umea,; Sweden.
OBJECTIVES: To measure the prevalence of HIV-1 infection in different subgroups of blood donors and to identify groups at high risk of acquiring HIV-1. METHODS: Between March 1988 and April 1991 all blood donors at Ilembula Lutheran Hospital, Tanzania were asked about their age,


The effects of HIV-2 infection in a rural area of Guinea-Bissau.
AIDS. 1994 Jul;8(7):977-82. Unique Identifier : AIDSLINE MED/95032930
Ricard D; Wilkins A; N'Gum PT; Hayes R; Morgan G; Da Silva AP; Whittle H; Medical Research Council Laboratories, Banjul, The Gambia.
OBJECTIVE: To investigate the clinical and immunologic effects, and pattern of mortality associated with HIV-2 infection. SETTING: A rural community in Guinea-Bissau . METHODS: Serologic screening of 2774 subjects aged > 14 years followed by studies of the prevalence of clinical an


Seroincidence of HIV-1 infection in African women of reproductive age: a prospective cohort study in Kigali, Rwanda, 1988-1992.
AIDS. 1994 Jul;8(7):983-6. Unique Identifier : AIDSLINE MED/95032931
Leroy V; Van de Perre P; Lepage P; Saba J; Nsengumuremyi F; Simonon A; Karita E; Msellati P; Salamon R; Dabis F; INSERM U. 330, University of Bordeaux II, France.
OBJECTIVE: To estimate the seroincidence of HIV-1 infection among women of reproductive age in Kigali, Rwanda . DESIGN: Fixed prospective cohort followed for 36 months between November 1988 and June 1992, as part of an ongoing study of mother-to-child transmission of HIV-1. SETTING:


Sexual behaviour survey in a rural area of northwest Tanzania.
AIDS. 1994 Jul;8(7):987-93. Unique Identifier : AIDSLINE MED/95032932
Konings E; Blattner WA; Levin A; Brubaker G; Siso Z; Shao J; Goedert JJ; Anderson RM; Imperial College, Parasite Epidemiology Research Group, London,; UK.
OBJECTIVE: Little is known about variations in patterns of sexual behaviour in different countries, cultures, and subpopulations that determine the spread of HIV-1. Quantitative studies are required to improve understanding. METHODS: To assess reported patterns of sexual behaviour, we administered a standardized quest


The impact of HIV-1 infection on mortality in children under 5 years of age in sub-Saharan Africa: a demographic and epidemiologic analysis.
AIDS. 1994 Jul;8(7):995-1005. Unique Identifier : AIDSLINE MED/95032933
Nicoll A; Timaeus I; Kigadye RM; Walraven G; Killewo J; Communicable Disease Surveillance Centre, Public Health; Laboratory Service, London. UK.
OBJECTIVE: To estimate the effects of the HIV-1 epidemic on mortality in children under 5 years of age in urban and rural populations in eastern and central, and southern Africa. METHODS: A lifetable method that allows for the effects of competing causes (i.e., mortality due to HIV and other causes) was used to estima


Tumour necrosis factor and eicosanoid production from monocytes exposed to HIV in vitro.
APMIS. 1994 Aug;102(8):603-11. Unique Identifier : AIDSLINE MED/95033124
Skot J; Kabrit P; Hansen JE; Nielsen JO; Nielsen L; Lundgren JD; University of Copenhagen, Department of Infectious Diseases,; Hvidovre Hospital, Denmark.
We investigated the hypothesis that exposure of monocytes to human immunodeficiency virus (HIV) augments production of proinflammatory mediators. The production of tumour necrosis factor alpha (TNF-alpha) and the eicosanoids PGE2 and LTB4 from human monocytes was evaluated after exposure to two strains of HIV (SSI-002


Nested primer PCR detection limits of HIV-1 in the background of increasing numbers of lysed cells.
Biotechniques. 1994 Jul;17(1):18-20. Unique Identifier : AIDSLINE MED/95033175
Zimmermann K; Pischinger K; Mannhalter JW; Dept. of Immunological Research, Immuno AG, Vienna, Austria.
Two-step cloning of antibody variable domains in a phage display vector.
Biotechniques. 1994 Jul;17(1):44, 46. Unique Identifier : AIDSLINE MED/95033183
Engelhardt O; Grabherr R; Himmler G; Ruker F; University of Agriculture, Vienna, Austria.
An efficient expression, purification and immunodetection system for recombinant gene products.
Biotechniques. 1994 Jul;17(1):94, 96, 98-9. Unique Identifier : AIDSLINE MED/95033197
Baier G; Baier-Bitterlich G; Couture C; Telford D; Giampa L; Altman A; La Jolla Institute for Allergy and Immunology, CA.
We describe a modification of the mammalian expression vector pRc/ CMV , which drives expression of inserted genes from either the human cytomegalovirus (CMV) immediate-early promoter or the bacteriophage T7 RNA polymerase prom


Intrapulmonary antigen deposition in the human lung: local responses.
Am J Respir Cell Mol Biol. 1994 Nov;11(5):607-14. Unique Identifier : AIDSLINE MED/95033273
Weissman DN; Bice DE; Crowell RE; Schuyler MR; West Virginia University School of Medicine, Morgantown.
We hypothesized that, as in animal models, localized deposition of antigen into the human lung would induce local inflammatory and immune responses in antigen-exposed sites. To test this hypothesis, segmental instillation of a well-characterized, highly immunogenic, soluble antigen, keyhole limpet hemocyanin (KLH) was


Recombinant human granulocyte-macrophage colony-stimulating factor in acquired or chemotherapy-induced neutropenia. An open clinical trial.
Acta Oncol. 1994;33(6):639-43. Unique Identifier : AIDSLINE MED/95033331
Piguet D; Chapuis B; Service d'Oncologie, Hopital des Cadolles, Neuchatel,; Switzerland.
This prospective open trial evaluated the efficacy and tolerability of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) in patients with established neutropenia, considering as the main endpoint the clinical benefit to the patients regarding clearing of infection or resuming chemotherapy a


[If children could decide (interview by Siv Barstad)]
J Sykepleien. 1994 Jan 18;82(1):32-3. Unique Identifier : AIDSLINE MED/95033641
Rogstad A
[Nurse--who are you? (interview by Siv Bartsad)]
J Sykepleien. 1994 Feb 1;82(2):24. Unique Identifier : AIDSLINE MED/95033650
Nygard AK
[It is about being alive (interview by Siv Barstad)]
J Sykepleien. 1994 Feb 1;82(2):26-8. Unique Identifier : AIDSLINE MED/95033652
Kiellerup K
[Malaysia: loser in the fight against AIDS (news)]
J Sykepleien. 1994 Feb 15;82(3):36. Unique Identifier : AIDSLINE MED/95033668
[Russia: lacking condoms in the fight against AIDS (news)]
J Sykepleien. 1994 Feb 15;82(3):36-7. Unique Identifier : AIDSLINE MED/95033669
The pharmacokinetics of fluconazole after a single intravenous dose in AIDS patients.
Br J Clin Pharmacol. 1994 Jul;38(1):77-9. Unique Identifier : AIDSLINE MED/95033889
Yeates RA; Ruhnke M; Pfaff G; Hartmann A; Trautmann M; Sarnow E; Pfizer-Mack Ltd, Illertissen, Germany.
The pharmacokinetics of fluconazole after a single 100 mg i.v. dose were studied in 10 healthy subjects (5 M; 5 F) and 10 HIV-positive patients (8 M; 2 F). The mean value of plasma clearance was 25% lower in the patient groups (17 +/- 6 (s.d.) vs 23 +/- 4 ml min-1; 95% CI of difference -11 to -0.7; P


The epidemiology of non-Hodgkin's lymphoma: why the increased incidence?
Oncology (Huntingt). 1994 Aug;8(8):67-73; discussion 73-8. Unique Identifier : AIDSLINE MED/95033957
Palackdharry CS; Medical College of Ohio, Toledo.
The incidence of non-Hodgkin s lymphoma continues to increase in the United States . Improvements in diagnostic techniques, changes in disease classifications, and the increase in AIDS-related lymphomas account for only a small percentage of the incr


Cervical neoplasia in women with HIV infection.
Oncology (Huntingt). 1994 Aug;8(8):83-9; discussion 89, 93-4. Unique Identifier : AIDSLINE MED/95033958
Maiman M; Department of Obstetrics and Gynecology, State University of New; York Health Science Center at Brooklyn.
HIV infections in women now account for 40% of all HIV infections worldwide, and the majority of new infections are due to heterosexual transmission. In the United States , 12% of AIDS cases occur in women and in certain high prevalence areas such as Brooklyn, New York, 25% of cases are


Pathology of acquired immunodeficiency syndrome in children.
Pediatr Hematol Oncol. 1994 Jul-Aug;11(4):351-5. Unique Identifier : AIDSLINE MED/95033960
Joshi VV; Department of Pathology and Laboratory Medicine, East Carolina; University School of Medicine, Greenville, North Carolina; 27858-4354.
Juvenile classic Kaposi's sarcoma: a report of two cases, one with family history.
Pediatr Hematol Oncol. 1994 Jul-Aug;11(4):409-16. Unique Identifier : AIDSLINE MED/95033966
Zurrida S; Agresti R; Cefalo G; Division of Surgical Oncology B, Istituto Nazionale Tumori,; Milan, Italy.
Two cases of juvenile classic Kaposi s sarcoma (KS), one with family history, are described, and the natural history of KS is briefly reviewed. Case 1a was a child whose disease ran an aggressive course and did not respond to therapy. Case 1b was the mother of the child: She had a relapsed localized form that was trea


The impact of HIV on older people: Part 2.
Nurs Stand. 1994 Aug 17-23;8(47):25-7. Unique Identifier : AIDSLINE MED/95034078
Marr J
This second article of two on HIV infection and its impact on older people concentrates on what type of research needs to be undertaken in this area, and calls for greater awareness of the problems that older people face in dealing with HIV.


Advice service launched for male prostitutes [news]
Nurs Stand. 1994 Aug 17-23;8(47):8. Unique Identifier : AIDSLINE MED/95034087
Hands-on experience: do teachers need it?
Nurs Stand. 1994 Aug 24-30;8(48):29-31. Unique Identifier : AIDSLINE MED/95034092
McHaffie HE
Discussion on the efficacy of the clinical involvement and credibility of nurse educators has been ongoing for a considerable time. The author sheds new light on the subject by referring to a survey of nurse education on HIV/AIDS in the UK. She concludes that while a measure of clinical experience is desirable in teac


US doctors baffled by HIV-infected baby [news]
Nurs Stand. 1994 Aug 31-Sep 6;8(49):16. Unique Identifier : AIDSLINE MED/95034102
Blank S
Number of AIDS cases reported in Lothian [news]
Nurs Stand. 1994 Sep 7-13;8(50):6. Unique Identifier : AIDSLINE MED/95034126
Call for improved nutritional training to help HIV patients.
Nurs Stand. 1994 Sep 14-21;8(51):13. Unique Identifier : AIDSLINE MED/95034127
Isolated extragenital HPV-thirties-group-positive bowenoid papulosis in an AIDS patient.
Br J Dermatol. 1994 Oct;131(4):577-80. Unique Identifier : AIDSLINE MED/95034181
Fader DJ; Stoler MH; Anderson TF; Department of Dermatology, University of Michigan, Ann Arbor; 48109.
We report a case of extragenital bowenoid papulosis in a man with AIDS. The lesions occurred on the anterolateral aspects of the neck, and were not associated with clinical genital or periungual involvement. In situ hybridization demonstrated abundant HPV DNA within the thirties group (31/33/35), in the absence of HPV


Familial occurrence of LGL leukaemia.
Br J Haematol. 1994 May;87(1):199-201. Unique Identifier : AIDSLINE MED/95034222
Loughran TP Jr; Kidd P; Poiesz BJ; Veterans Administration Hospital, Syracuse, N.Y. 13210.
The aetiology of LGL leukaemia is now known; however, we recently detected HTLV-II from such a patient. We describe here the occurrence of LGL leukaemia in a mother and her son. Serum from the son reacted to HTLV-I/II gag proteins, but not a recombinant HTLV-I env protein p21e; serum from the mother was negative. PCR


Peripheral mononuclear cells of haemophiliacs with chronic liver disease are infected with replicating hepatitis C virus.
Br J Haematol. 1994 May;87(1):215-7. Unique Identifier : AIDSLINE MED/95034227
Henin C; Makris M; Brown J; Peake IR; Preston EF; Section of Molecular Genetics, Royal Hallamshire Hospital,; Sheffield.
Most haemophiliacs treated with non-virally inactivated concentrates have been infected with the hepatitis C virus (HCV). 19/21 (90%) patients with HCV antibody were found to have HCV RNA in their serum and in 16 of these it was also detected in peripheral blood mononuclear cells (PBMC). We used specific primers to de


Possible role of granulocyte-macrophage colony stimulating factor (GM-CSF) on the rapid progression of AIDS-related Kaposi's sarcoma lesions in vivo.
Br J Haematol. 1994 Jun;87(2):413-4. Unique Identifier : AIDSLINE MED/95034274
Hermans P; Gori A; Lemone M; Franchioly P; Clumeck N; Division of Infectious Diseases, Saint-Pierre University; Hospital, Brussels, Belgium.
Drug-related neutropenia is a common observation in AIDS patients. Haematological growth factors are therefore increasingly used in combination with myelotoxic agents to reduce the risk of infection and to improve the haematological tolerance of these regimens. We report a case of an AIDS patient with Kaposi s sarcoma


Increased soluble IL-2 receptor levels in HCV-infected haemophiliacs: a possible indicator of liver disease severity.
Br J Haematol. 1994 Jun;87(2):419-21. Unique Identifier : AIDSLINE MED/95034276
Makris M; Preston FE; Ralph S; University Department of Haematology, Royal Hallamshire Hospital,; Sheffield.
We have measured sIL-2R in 60 haemophiliacs and 20 male control subjects. Haemophiliacs were grouped according to their HIV/HCV antibody status. Group 1 (n = 20) comprised HIV + ve/HCV + ve, group 2 (n = 27) HIV - ve/HCV + ve and group 3 (n = 13) HIV - ve/HCV - ve. Group 4 comprised the normal control subjects. We als


T cell subpopulation phenotypes in filarial infections: CD27 negativity defines a population greatly enriched for Th2 cells.
Int Immunol. 1994 Jul;6(7):1003-9. Unique Identifier : AIDSLINE MED/95034452
Elson LH; Shaw S; Van Lier RA; Nutman TB; Laboratory of Parasitic Diseases, National Institute of Allergy; and Infectious Diseases, Bethesda, MD 20892.
Three-color flow cytometric analysis was used to define surface markers which identify the Th2-type CD4+ cells responsible for the eosinophilia and elevated serum IgE typical of tissue invasive helminth infections. A group of six mAbs to well known cell surface markers were screened for differential expression on CD4+


IL-12 transiently induces IFN-gamma transcription and protein synthesis in human CD4+ allergen-specific Th2 T cell clones.
Int Immunol. 1994 Jul;6(7):1091-6. Unique Identifier : AIDSLINE MED/95034461
Yssel H; Fasler S; de Vries JE; de Waal Malefyt R; DNAX Research Institute for Molecular and Cellular Biology, Human; Immunology Department, Palo Alto, CA 94304-1104.
IL-12 is a cytokine produced by monocytes and Epstein-Barr virus-transformed B cells which initiates Th1 responses by inducing the development of CD4+, IFN-gamma producing Th1 T cells in mouse and human. We have previously reported that allergen-specific CD4+ Th2 T cell clones produce IFN-gamma, following activation b


CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression.
Int Immunol. 1994 Jul;6(7):995-1001. Unique Identifier : AIDSLINE MED/95034470
Shinkai Y; Alt FW; Howard Hughes Medical Institute, Boston, MA.
Recent studies have shown that TCR beta chain expression can effect the differentiation of CD4-CD8- double-negative (DN) thymocytes to CD4+CD8+ double-positive (DP) thymocytes. The TCR beta chain is expressed on the surface of DP thymocytes in association with CD3 gamma, delta and epsilon chains, suggesting a potentia


Treatment of cytomegalovirus retinitis with intravitreal injection of liposome encapsulated ganciclovir in a patient with AIDS.
Br J Ophthalmol. 1994 Sep;78(9):677-80. Unique Identifier : AIDSLINE MED/95034557
Akula SK; Ma PE; Peyman GA; Rahimy MH; Hyslop NE Jr; Janney A; Ashton P; Department of Medicine, Tulane University Medical Center, New; Orleans, LA.
To study its safety and efficacy in treating cytomegalovirus ( CMV ) retinitis, an AIDS patient received an intravitreal injection of liposome encapsulated ganciclovir in the right eye. The left eye served as a control, receivi


HIV: the surgeon's perspective. Part 1. Update of pathogenesis, epidemiology and management and risk of nosocomial transmission.
Br J Oral Maxillofac Surg. 1994 Aug;32(4):222-30. Unique Identifier : AIDSLINE MED/95034577
Porter SR; Scully C; Academic Department of Oral Medicine, Eastman Dental Institute,; London.
HIV: the surgeon's perspective. Part 2. Diagnosis and management of non-malignant oral manifestations.
Br J Oral Maxillofac Surg. 1994 Aug;32(4):231-40. Unique Identifier : AIDSLINE MED/95034578
Porter S; Scully C; Joint Department of Oral Medicine, Eastman Dental Institute,; London.
HIV: the surgeon's perspective. Part 3. Diagnosis and management of malignant neoplasms.
Br J Oral Maxillofac Surg. 1994 Aug;32(4):241-7. Unique Identifier : AIDSLINE MED/95034579
Porter S; Scully C; Joint Department of Oral Medicine, Eastman Dental Institute,; London.
A 19-nucleotide sequence upstream of the 5' major splice donor is part of the dimerization domain of human immunodeficiency virus 1 genomic RNA.
Biochemistry. 1994 Nov 15;33(45):13464-74. Unique Identifier : AIDSLINE MED/95034780
Laughrea M; Jette L; McGill AIDS Centre, Lady Davis Institute for Medical Research,; Sir Mortimer B. Davis-Jewish General Hospital, Montreal, Quebec,; Canada.
The genome of all retroviruses, including human immunodeficiency virus type 1 (HIV-1), consists of two identical RNAs noncovalently linked near their 5 end. Dimerization of genomic RNA is thought to modulate several steps in the retroviral life cycle, such as recombination, translation, and encapsidation. We report t


Sexual communication is associated with condom use by sexually active incarcerated adolescents.
J Adolesc Health. 1994 Jul;15(5):383-8. Unique Identifier : AIDSLINE MED/95034900
Rickman RL; Lodico M; DiClemente RJ; Morris R; Baker C; Huscroft S; University of California, Center for AIDS Prevention Studies; (CAPS), San Francisco 94105.
PURPOSE: Incarcerated adolescents are at increased risk for infection by sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV). Moreover, condom use by this population is extremely low. Although interpersonal variables such as sexual communication have been found to be associated with cond


HIV infection and AIDS in adolescents. A position paper of the Society for Adolescent Medicine.
J Adolesc Health. 1994 Jul;15(5):427-34. Unique Identifier : AIDSLINE MED/95034908
Sex workers and HIV [editorial; comment]
AIDS Care. 1994;6(3):267-8. Unique Identifier : AIDSLINE MED/95035161
Hart G; Whittaker D
HIV prevalence no higher among female drug injectors also involved in prostitution [see comments]
AIDS Care. 1994;6(3):269-76. Unique Identifier : AIDSLINE MED/95035162
Rhodes T; Donoghoe M; Hunter G; Stimson GV; Centre for Research on Drugs and Health Behaviour, Charing Cross; and Westminster Medical School, University of London, UK.
To assess the prevalence of HIV infection among female drug injectors involved in prostitution and female drug injectors not involved in prostitution, survey-based interviews were undertaken with 308 female drug injectors in 1990 and 1991. Confirmed saliva test results show 12.9% HIV prevalence among female drug injec


Male prostitutes and safe sex: different settings, different risks [see comments]
AIDS Care. 1994;6(3):277-88. Unique Identifier : AIDSLINE MED/95035163
de Graaf R; Vanwesenbeeck I; van Zessen G; Straver CJ; Visser JH; Netherlands Institute of Social Sexological Research (NISSO),; Utrecht, The Netherlands.
Twenty-seven male prostitutes were interviewed extensively about their work and considerations relating to safe sex with clients. Important differences were found between street prostitutes and those working at home. Street-workers were more likely to be using hard drugs, to have a heterosexual preference, to have no


Why do men buy sex and what are their assessments of the HIV-related risks when they do? [see comments]
AIDS Care. 1994;6(3):289-301. Unique Identifier : AIDSLINE MED/95035164
McKeganey N; Centre for Drug Misuse Research, University of Glasgow, UK.
The belief that female prostitution might play a key role in the heterosexual spread of HIV infection has led to a great deal of attention being focused on the activities of women who sell sex. By contrast, the activities of men who buy sex has been largely ignored. One of the reasons for this has undoubtedly been the


A comparison of public health care utilization by gay men and intravenous drug users with AIDS in San Francisco.
AIDS Care. 1994;6(3):303-16. Unique Identifier : AIDSLINE MED/95035165
Johnston D; Smith K; Stall R; Joint Program in Medical Anthropology, University of California,; San Francisco.
A group of gay-identified men (n = 81) and intravenous drug users (n = 88) diagnosed with AIDS in San Francisco were surveyed regarding their use and satisfaction with their health care services. The interview contained a mix of qualitative and quantitative questions. The two groups of AIDS patients were not statistic


A bridge too near? Injecting drug users' sexual behaviour.
AIDS Care. 1994;6(3):317-26. Unique Identifier : AIDSLINE MED/95035166
McDonald C; Loxley W; Marsh A; National Centre for Research into the Prevention of Drug Abuse,; Curtin University of Technology, Perth, Western Australia.
One-hundred-and-fifty injecting drug users were interviewed about their sexual behaviour, and types of sexual relationships and partners in the past year. The aims of the study were to assess the extent of changes in sexual HIV-risk behaviour patterns and to understand aspects of respondents sexual relationships, as


Medical student experience with AIDS and needle disposal behaviour.
AIDS Care. 1994;6(3):327-30. Unique Identifier : AIDSLINE MED/95035167
Muskin PR; Goodwin MA; Department of Psychiatry, Columbia University, College of; Physicians and Surgeons, New York, NY 10032.
A survey of medical students at Columbia University, College of Physicians and Surgeons, was conducted to investigate needle-handling behaviour with HIV positive patients. Recapping a used needle increases the students risk of a needle stick. There were 160 responses, yielding a response rate of 27.6%. Students place


Regular partners and risky behaviour: why do gay men have unprotected intercourse?
AIDS Care. 1994;6(3):331-41. Unique Identifier : AIDSLINE MED/95035168
McLean J; Boulton M; Brookes M; Lakhani D; Fitzpatrick R; Dawson J; McKechnie R; Hart G; Academic Department of Public Health, St Mary's Hospital Medical; School, London, UK.
Studies in both the UK and the USA continue to show that gay and bisexual men put themselves at risk of exposure to HIV through unprotected intercourse, most often with regular partners. As part of a larger study of homosexually active men, 310 men who had had unprotected anal intercourse with a man in the previous ye


Community, solidarity and action--Grupo Pela VIDDA, Brazil.
AIDS Care. 1994;6(3):343-8. Unique Identifier : AIDSLINE MED/95035169
Aggleton P; Pedrosa JS; Goldsmiths' College, University of London, England.
Non-governmental community-based organizations have been identified as central to effective HIV/AIDS related prevention and care. This paper reports on the activities and achievement of one such organization--Grupo Pela VIDDA, Brazil . It details the philosophy and commitments which


Whose health is it? Views about decision-making and information-seeking from people with HIV infection and their professional carers.
AIDS Care. 1994;6(3):349-56. Unique Identifier : AIDSLINE MED/95035170
Catalan J; Brener N; Andrews H; Day A; Cullum S; Hooker M; Gazzard B; Department of Psychological Medicine, Charing Cross and; Westminster Medical School, London, UK.
The views of people with HIV and their professional carers about patients views on involvement in decision-making and information-seeking were studied, using a standardized self-report instrument. Patients and staff reported high levels of desire for patients involvement in their care, but there were important diffe


WHO global AIDS statistics.
AIDS Care. 1994;6(3):367-8. Unique Identifier : AIDSLINE MED/95035171
[Campylobacter gastroenteritis in patients with human immunodeficiency virus infection]
Enferm Infecc Microbiol Clin. 1994 Aug-Sep;12(7):332-6. Unique Identifier : AIDSLINE MED/95035194
Leyes M; Vara F; Reina J; Riera M; Siquier B; Villalonga C; Servicio de Medicina Interna, Hospital Son Dureta, Palma de; Mallorca.
BACKGROUND: Campylobacter bacteria are frequent, and usually slight causes of diarrhea in a normal host while in an immunosuppressed host the diarrhea may lead to severe pictures. The aim of this study was to analyze the clinical features of gastroenteritis by Campylobacter spp. in hospitalized seronegative patients a


[Cytomegalovirus colitis simulating neoplasm in a patient with HIV infection]
Enferm Infecc Microbiol Clin. 1994 Aug-Sep;12(7):341-5. Unique Identifier : AIDSLINE MED/95035196
de la Prieta R; Montejo M; Aguirrebengoa K; Ibanez de Maeztu JC; Otermin I; Aguirre C; Servicio de Medicina Interna, Universidad del Pais Vasco,; Hospital de Cruces, Baracaldo, Vizcaya.
AIM: Cytomegalovirus colitis occurs in at least 5-10% of patients with AIDS. The most usual form of clinical presentation is that of a chronic picture of diarrhea, fever and abdominal pain in a patient with AIDS with a CD4 lymphocyte count lower than 100/mm3, although it can be the diagnostic index for AIDS up to in 2


[Lingual tuberculosis in an HIV-positive patient (letter)]
Enferm Infecc Microbiol Clin. 1994 Aug-Sep;12(7):361-2. Unique Identifier : AIDSLINE MED/95035204
de Pablo MA; Lamelas JA
[Schonlein-Henoch purpura assocated with HIV infection (letter)]
Enferm Infecc Microbiol Clin. 1994 Aug-Sep;12(7):363-4. Unique Identifier : AIDSLINE MED/95035206
de la Prieta R; Montejo M; Aguirrebengoa K; Ibanez de Maezta JC; Otermin I; Aguirre C
Retroviral vectors containing chimeric promoter/enhancer elements exhibit cell-type-specific gene expression.
Hum Gene Ther. 1994 Jun;5(6):667-77. Unique Identifier : AIDSLINE MED/95035211
Couture LA; Mullen CA; Morgan RA; National Heart, Lung, and Blood Institute, National Institutes of; Health, Bethesda, MD 20892.
Retroviral vectors were constructed in which the U3 promoter/enhancer of Moloney murine leukemia (Mo-MLV) was replaced by the corresponding region from five related murine retroviruses--AKR murine leukemia virus (AKV), Harvey murine sarcoma virus (HaMSV), myeloproliferative sarcoma virus (MPSV), SL3-3, and the NZB-xen


Recombinant retroviral vector delivered intramuscularly localizes to the site of injection in mice.
Hum Gene Ther. 1994 Jun;5(6):693-9. Unique Identifier : AIDSLINE MED/95035213
Sajjadi N; Kamantigue E; Edwards W; Howard T; Jolly D; Mento S; Chada S; Viagene, Incorporated, San Diego, CA 92121.
A murine retroviral vector encoding the human immunodeficiency virus type 1 (HIV-1) env and rev genes can be used to induce cytotoxic T lymphocyte responses. Immune responses can be induced by an ex vivo treatment, in which autologous cells are transduced in vitro and re-introduced to the donor, or by direct administr


Gene therapy for human immunodeficiency virus infection: genetic antiviral strategies and targets for intervention.
Hum Gene Ther. 1994 Aug;5(8):927-39. Unique Identifier : AIDSLINE MED/95035224
Dropulic B; Jeang KT; Molecular Virology Section, National Institutes of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.
Gene therapeutic strategies for the treatment of human immunodeficiency virus type 1 (HIV-1) infection have received increased attention due to lack of chemotherapeutic drugs or vaccines that show long-term efficacy in vivo. An emerging group, referred to here as genetic antivirals, is reviewed. Genetic antivirals are


A phase I clinical trial to evaluate the safety and biological activity of HIV-IT (TAF) (HIV-1IIIBenv-transduced, autologous fibroblasts) in asymptomatic HIV-1 infected subjects.
Hum Gene Ther. 1994 Aug;5(8):997-1017. Unique Identifier : AIDSLINE MED/95035231
Galpin JE; Casciato DA; Richards SB
Nosocomial transmission of HIV infection [editorial]
Int J STD AIDS. 1994 Jul-Aug;5(4):235-8. Unique Identifier : AIDSLINE MED/95035232
Sherrard JS; Bingham JS
Effective single dose treatment of uncomplicated gonorrhoea [editorial]
Int J STD AIDS. 1994 Jul-Aug;5(4):239-43. Unique Identifier : AIDSLINE MED/95035233
Korting HC; Kollmann M
Chlamydial ocular infection: efficacy of partner notification by patient referral.
Int J STD AIDS. 1994 Jul-Aug;5(4):244-7. Unique Identifier : AIDSLINE MED/95035234
Patel HC; Viswalingam ND; Goh BT; Diagnostic clinic, Moorfield's Eye Hospital, London, UK.
Records on 254 patients with chlamydial ocular infection observed over a period of 67 months at the Moorfield s Eye Hospital were reviewed retrospectively in relation to sexual partners in the 6 months prior to diagnosis. Contactable partners were given an appointment through index patients to attend our clinic. Those


Long-term impact of HIV diagnosis on mood and substance use--St Stephen's cohort study.
Int J STD AIDS. 1994 Jul-Aug;5(4):248-52. Unique Identifier : AIDSLINE MED/95035235
Jadresic D; Riccio M; Hawkins DA; Wilson B; Shanson DC; Thompson C; St Stephen's Clinic, Charing Cross & Westminster Medical School,; London, UK.
Twenty HIV positive and 68 HIV negative subjects were assessed by the Hospital Anxiety and Depression Scale and by the Alcohol and Drugs Frequency Schedule immediately prior to notification of their HIV serostatus and 6 months after serodiagnosis. The 2 groups did not differ significantly in levels of anxiety or depre


The cost effectiveness of treatment of genital warts with podophyllotoxin [see comments]
Int J STD AIDS. 1994 Jul-Aug;5(4):253-6. Unique Identifier : AIDSLINE MED/95035236
Mohanty KC; Department of Genitourinary Medicine, St Luke's Hospital,; Bradford, West Yorkshire, UK.
The cost effectiveness of 25% podophyllin resin and 0.5% podophyllotoxin solution in the treatment of genital warts in Genitourinary Medicine Clinic attenders was studied. Although the average treatment cost for a course of podophyllotoxin was more than that for podophyllin resin (20.75 pounds v. 14.95 pounds respecti


Effect of sexual practices on T cell subsets and delayed hypersensitivity in transsexuals and female sex workers.
Int J STD AIDS. 1994 Jul-Aug;5(4):257-61. Unique Identifier : AIDSLINE MED/95035237
Ratnam KV; National Skin Centre, Singapore.
To determine whether ano-receptive unprotected sexual intercourse (SI) practised by transsexuals produces immunological abnormalities we compared delayed hypersensitivity skin tests (DTH) and T cell helper (CD4) and suppressor (CD8) subsets in 57 transsexuals and 69 female sex worker controls. The populations were mat


Management of STDs and cost of treatment in primary health care centres in Pikine, Senegal.
Int J STD AIDS. 1994 Jul-Aug;5(4):262-7. Unique Identifier : AIDSLINE MED/95035238
Van der Veen FH; Ndoye I; Guindo S; Deschampheleire I; Fransen L; EEC AIDS Task Force, Brussels, Belgium.
We studied the current management of STD-related syndromes by urban health facilities in Pikine ( Senegal ) in 252 consecutive patients presenting with STD-related complaints, to assess the cost and effectiveness of services and to estimate the potential benefit by introducing manag


Evaluation of a safe-sex intervention programme among sex workers in Singapore.
Int J STD AIDS. 1994 Jul-Aug;5(4):268-72. Unique Identifier : AIDSLINE MED/95035239
Archibald CP; Chan RK; Wong ML; Goh A; Goh CL; Department of Community, Occupational and Family Medicine,; National University of Singapore.
The purpose of this study was to evaluate the effects of a brief intervention programme on STD knowledge, condom use and gonorrhoea incidence among sex workers in Singapore . A controlled before-and-after study design with non-random assignment of sex workers was used, supplement


Epidemiological characteristics on human immunodeficiency virus infection and acquired immunodeficiency syndrome in Japan.
Int J STD AIDS. 1994 Jul-Aug;5(4):273-8. Unique Identifier : AIDSLINE MED/95035240
Miyazaki M; Naemura M; Planning Division, Water Supply and Environmental Sanitation; Department, Ministry of Health and Welfare, Tokyo, Japan.
The first case of human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) in Japan was diagnosed in a homosexual male in 1985. The Ministry of Health and Welfare formed the AIDS Surveillance Committee, which published HIV seropositive and AIDS data at


Survival and medical intervention in southern Brazilian AIDS patients.
Int J STD AIDS. 1994 Jul-Aug;5(4):279-83. Unique Identifier : AIDSLINE MED/95035241
Santos B; Beck EJ; Peixoto MF; Servico de Infectologia, Hospital Nossa Senhora da Conceicao,; Porto Alegre, Brazil.
The aim of the study was to describe survival patterns of Southern Brazilian AIDS patients: 224 predominantly working class AIDS patients were treated in an AIDS referral centre in Porto Alegre between October 1986 and September 1991. The caseload increased progressively, as did the number of female AIDS cases treated


Self sampling as part of screening for sexually transmitted diseases in clinic attenders. A preliminary study.
Int J STD AIDS. 1994 Jul-Aug;5(4):284-6. Unique Identifier : AIDSLINE MED/95035242
Markos AR; Wade AA; Walzman M; Shahmanesh M; Department of Genito-Urinary Medicine, Coventry and Warwickshire; Hospital.
Self sampling of the secretions of the female genital tract for microbiological investigations for Neisseria gonorrhoeae, Chlamydia trachomatis and Trichomonas vaginalis was assessed in female attenders of the genitourinary medicine clinic in Coventry and Warwickshire Hospital. The purpose of the study was to evaluate


Condom use among female commercial sex workers and male clients in Hong Kong.
Int J STD AIDS. 1994 Jul-Aug;5(4):287-9. Unique Identifier : AIDSLINE MED/95035243
Wong KH; Lee SS; Lo YC; Lo KK; AIDS Unit, Department of Health, Hong Kong.
The use of condoms is an aid to protection against human immunodeficiency virus (HIV) infection and other sexually transmitted diseases (STDs). In a one-and-a-half month period in mid-1993, 190 commercial female sex workers and 633 male clients of 8 Social Hygiene Clinics in


Prevalence of neurosyphilis at Government Rajaji Hospital, Madurai, India.
Int J STD AIDS. 1994 Jul-Aug;5(4):290-2. Unique Identifier : AIDSLINE MED/95035244
Ganesh R; Stanley A; Ganesh N; Venkatram MK; Alagappan R; Government Rajaji Hospital, Madurai, India.
Forty patients (34 males and 6 females) with neurological complaints/manifestations and with a past history of multiple sexual partners attending the Government Rajaji Hospital, Madurai, India between April 1992 and October 1992 were investigated for neurosyphilis. Metabolic disorde


Invasive multiple sinusitis by Aspergillus fumigatus in a patient with AIDS.
Int J STD AIDS. 1994 Jul-Aug;5(4):293-5. Unique Identifier : AIDSLINE MED/95035245
Libanore M; Pastore A; Frasconi PC; Rossi MR; Bedetti A; Sighinolfi L; Ghinelli F; Department of Infectious Diseases, St. Anna Hospital, Ferrara,; Italy.
Bilateral spontaneous pneumothorax in AIDS--successful treatment with talc pleurodesis following failure with tetracycline sclerotherapy.
Int J STD AIDS. 1994 Jul-Aug;5(4):296-8. Unique Identifier : AIDSLINE MED/95035246
Nageswaran A; Priestley CJ; Patel R; Kyi TT; Kinghorn GR; Department of Genito-urinary Medicine, Royal Hallamshire; Hospital, Sheffield, UK.
An audit of Gynatren (a Lactobacillus acidophilus lyophilisate) vaccination in women with recurrent bacterial vaginosis.
Int J STD AIDS. 1994 Jul-Aug;5(4):299. Unique Identifier : AIDSLINE MED/95035247
Pattman RS; Sankar KN; Watson PG; Wardropper AG; Department of Genito Urinary Medicine, Newcastle General; Hospital, Newcastle upon Tyne, UK.
An audit of the referral of cases of gonococcal infection to a genitourinary medicine clinic [see comments]
Int J STD AIDS. 1994 Jul-Aug;5(4):299-300. Unique Identifier : AIDSLINE MED/95035248
Rodgers C; O'Mahony C; Mannion P; Chester Royal Infirmary, UK.
Amines in semen-free vaginal secretions [letter]
Int J STD AIDS. 1994 Jul-Aug;5(4):301-2. Unique Identifier : AIDSLINE MED/95035249
Jones BM
Prevalence of Cryptosporidium parvum in AIDS and immunocompetent patients in Uganda [letter]
Int J STD AIDS. 1994 Jul-Aug;5(4):302-3. Unique Identifier : AIDSLINE MED/95035250
Ravera M; Reggiori A; Cocozza E
Liquid chromatographic analysis, stability and protein binding studies of the anti-HIV agent benzoic acid, 2-chloro-5[[(1-methylethoxy)thioxomethyl]amino]-,1-methylethyl ester.
J Pharm Biomed Anal. 1994 May;12(5):693-8. Unique Identifier : AIDSLINE MED/95035274
Nomeir AA; McComish MF; Mongan AL; Covey JM; Ferrala NF; Arthur D. Little, Inc., Acorn Park, Cambridge, MA 02140.
A method was developed for the assay of benzoic acid, 2-chloro-5-[[(1-methylethoxyl)thioxomethyl]amino]-,1-meth yle thyl ester (NSC 629243) in hamster, mouse, human and, to a limited extent, dog plasma. Protein in 0.5 ml of plasma was precipitated with four volumes of methanol and the supernatant was analysed for NSC


Importance of primer selection in the application of PCR technology to the diagnosis of bovine leukemia virus.
J Vet Diagn Invest. 1994 Jul;6(3):297-301. Unique Identifier : AIDSLINE MED/95035282
Marsolais G; Dubuc R; Bergeron J; Morrey JD; Kelly EJ; Jackson MK; Ministere de l'Agriculture des Pecheries et de l'Alimentation; du Quebec, Canada.
The polymerase chain reaction (PCR) was used to detect bovine leukemia virus in bovine blood samples. When applied to leucocytes extracted from the blood samples, the standard method of DNA extraction gave good correlation with agar gel immunodiffusion, but a method in which 5 microliters of blood was the starting mat


Histopathology and viral antigen distribution in lymph nodes of cats naturally infected with feline immunodeficiency virus.
J Vet Med Sci. 1994 Jun;56(3):523-8. Unique Identifier : AIDSLINE MED/95035470
Matsumura S; Ishida T; Washizu T; Tomoda I; Department of Clinical Pathology, Nippon Veterinary and Animal; Science University, Tokyo, Japan.
Lymph nodes from cats with natural feline immunodeficiency virus (FIV) infection were examined histopathologically for characterization of lesions in the symptomatic and terminal stages. The localization of viral antigen was also studied in the nodes by immunohistochemistry using a monoclonal antibody to FIV p24. In a


Engraftment of HTLV-I-transformed human T-cell line into SCID mice with NK cell function.
J Vet Med Sci. 1994 Jun;56(3):601-3. Unique Identifier : AIDSLINE MED/95035491
Ohsugi T; Ishibashi K; Shingu M; Nomura T; Department of Virology, Kurume University School of Medicine,; Osaka University Medical School, Japan.
HTLV-I-transformed human T-cell line, MT-2, has been reported to successfully proliferate in only the SCID mice with depletion of NK cell function. However, MT-2 cells could be engrafted into SCID mice possessing normal NK cell function in this study. MT-2 cells (5-7 x 10(7) cells) were intraperitoneally injected into


Dysphoria and immune status in postpartum women.
Biol Psychol. 1994 Jul;37(3):199-206. Unique Identifier : AIDSLINE MED/95035554
Hucklebridge FH; Smith MD; Clow A; Evans P; Glover V; Taylor A; Adams D; Lydyard PM; Division of Biomedical and Health Sciences, University of; Westminster, London, UK.
This study investigated the relationship between psychological factors and circulating immune cell populations in postpartum women. The study group was 75 women who had vaginal deliveries and were free of psychotropic medication. Four days postpartum each subject completed three mood questionnaires, and a small blood


Multiple-drug-resistant tuberculosis.
Clin Infect Dis. 1994 Jul;19(1):1-8; quiz 9-10. Unique Identifier : AIDSLINE MED/95035602
Jacobs RF; Division of Pediatric Infectious Diseases, Arkansas Children's; Hospital, Little Rock.
Diagnosis of Chlamydia pneumoniae infection in patients with community-acquired pneumonia by polymerase chain reaction enzyme immunoassay.
Clin Infect Dis. 1994 Jul;19(1):157-60. Unique Identifier : AIDSLINE MED/95035614
Gaydos CA; Eiden JJ; Oldach D; Mundy LM; Auwaerter P; Warner ML; Vance E; Burton AA; Quinn TC; Division of Infectious Diseases, Johns Hopkins University School; of Medicine, Baltimore, Maryland 21205.
We conducted a prospective study of 385 patients who had community-acquired pneumonia with use of a modified polymerase chain reaction (PCR) assay that detects amplified DNA by enzyme immunoassay (EIA). We used PCR-EIA to improve detection of Chlamydia pneumoniae infection and to differentiate C. pneumoniae infection


Adult respiratory distress syndrome associated with disseminated toxoplasmosis.
Clin Infect Dis. 1994 Jul;19(1):169-71. Unique Identifier : AIDSLINE MED/95035618
Gandhi S; Lyubsky S; Jimenez-Lucho V; Medical Service, Northport Veterans Affairs Medical Center, Stony; Brook, New York.
Diffuse lung injury may result as a complication of disseminated toxoplasmosis in patients with AIDS. We report the case of an AIDS patient who had multiple organ failure associated with disseminated toxoplasmosis. The patient died because of ventilatory failure, and at autopsy findings in regard to the lungs were con


Antiretroviral therapy for infection due to human immunodeficiency virus in children.
Clin Infect Dis. 1994 Jul;19(1):177-96. Unique Identifier : AIDSLINE MED/95035620
Pizzo PA; Wilfert C; Pediatric Branch, National Cancer Institute, National Institutes; of Health, Bethesda, Maryland.
Disseminated infection due to Mycobacterium malmoense in a patient infected with human immunodeficiency virus [letter]
Clin Infect Dis. 1994 Jul;19(1):203-4. Unique Identifier : AIDSLINE MED/95035625
Chocarra A; Gonzalez Lopez A; Breznes MF; Canut A; Rodriguez J; Diego JM
Mycoplasma pneumoniae infection in a child with AIDS [letter]
Clin Infect Dis. 1994 Jul;19(1):207. Unique Identifier : AIDSLINE MED/95035628
Jensen JS; Heilmann C; Valerius NH
Wasting associated with cocaine and heroin use in patients infected with human immunodeficiency virus [letter]
Clin Infect Dis. 1994 Jul;19(1):209-10. Unique Identifier : AIDSLINE MED/95035631
Hoy JF; Flanigan TP
Increased survival of young infants with Pneumocystis carinii pneumonia and acute respiratory failure with early steroid administration [letter]
Clin Infect Dis. 1994 Jul;19(1):212-3. Unique Identifier : AIDSLINE MED/95035634
Barone SR; Aiuto LT; Krilov LR
Pure red cell aplasia, peripheral thrombocytopenic purpura, and parvovirus B19 infection in a women seropositive for human immunodeficiency virus [letter]
Clin Infect Dis. 1994 Jul;19(1):215. Unique Identifier : AIDSLINE MED/95035636
Blanche P; Wyplosz B; Herry I; Salmon D; Sicard D
Infection due to Bacillus cereus in an injection drug user with AIDS: bacteremia without morbidity [letter]
Clin Infect Dis. 1994 Jul;19(1):216-7. Unique Identifier : AIDSLINE MED/95035637
Ball SC; Sepkowitz K
Pyrimethamine/sulfadoxine for prevention of Pneumocystis carinii pneumonia in patients infected with the human immunodeficiency virus [letter]
Clin Infect Dis. 1994 Jul;19(1):218-9. Unique Identifier : AIDSLINE MED/95035639
Jurado R; Garcia-Herola A; Garcia-Lazaro M; Kindelan JM; Villanueva JL; Torre-Cisneros J
Invasive aspergillosis in patients with AIDS [letter]
Clin Infect Dis. 1994 Jul;19(1):222. Unique Identifier : AIDSLINE MED/95035642
Wallace MR; Kanak RJ; Newton JA; Kennedy CA
Delayed-type hypersensitivity anergy in human immunodeficiency virus-infected persons screened for infection with Mycobacterium tuberculosis.
Clin Infect Dis. 1994 Jul;19(1):26-32. Unique Identifier : AIDSLINE MED/95035648
Huebner RE; Schein MF; Hall CA; Barnes SA; Clinical Research Branch, Centers for Disease Control and; Prevention, Atlanta, Georgia 30333.
A total of 479 human immunodeficiency virus (HIV)-infected persons at an HIV clinic in Florida and a tuberculosis clinic in New Jersey were skin-tested with tuberculin, tetanus toxoid, mumps antigen, and Candida antigen in a study of the prevalence of delayed-type hypersensitivity (DTH) anergy and the usefulness of tw


Gastrointestinal leishmaniasis in human immunodeficiency virus-infected patients: report of five cases and review [see comments]
Clin Infect Dis. 1994 Jul;19(1):48-53. Unique Identifier : AIDSLINE MED/95035651
Laguna F; Garcia-Samaniego J; Soriano V; Valencia E; Redondo C; Alonso MJ; Gonzalez-Lahoz JM; Service of Infectious Diseases, Instituto de Salud Carlos III,; Madrid, Spain.
We describe five cases of gastrointestinal leishmaniasis in patients with human immunodeficiency virus infection and review 10 additional cases reported in the literature. All of the patients had CD4+ cell counts of


Efficacy of rifabutin in the treatment of disseminated infection due to Mycobacterium avium complex. The Rifabutin Treatment Group.
Clin Infect Dis. 1994 Jul;19(1):84-6. Unique Identifier : AIDSLINE MED/95035656
Sullam PM; Gordin FM; Wynne BA; Department of Medicine, Veterans Affairs Medical Center, San; Francisco, California 94121.
The incidence of infection with Mycobacterium avium complex (MAC) is increasing among patients with AIDS. Although numerous antimicrobial regimens have been proposed as treatment for this infection, it is unclear which therapy is most effective. For this reason, we prospectively evaluated rifabutin (600 mg/d) vs. a pl


Newer developments in therapy for endemic mycoses.
Clin Infect Dis. 1994 Aug;19 Suppl 1:S28-32. Unique Identifier : AIDSLINE MED/95035662
Kauffman CA; Department of Internal Medicine, University of Michigan Medical; School, Ann Arbor.
In the 1960s and 1970s, amphotericin B was the only effective therapy for serious systemic endemic fungal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Sporothrix schenckii. In the 1980s, ketoconazole was introduced as therapy for endemic mycoses; after this antifungal agent was introduced, s


Invasive aspergillosis in patients with AIDS.
Clin Infect Dis. 1994 Aug;19 Suppl 1:S41-8. Unique Identifier : AIDSLINE MED/95035664
Khoo SH; Denning DW; Department of Infectious Diseases and Tropical Medicine, North; Manchester General Hospital, United Kingdom.
The prolonged survival of profoundly immunocompromised patients with AIDS has contributed to the increasing recognition of aspergillus infections as an emerging problem. Nevertheless, many of these infections continue to be diagnosed only at autopsy. In this article we review details of 293 reported cases. Invasive as


On the development of antifungal agents: perspective of the U.S. Food and Drug Administration.
Clin Infect Dis. 1994 Aug;19 Suppl 1:S54-8. Unique Identifier : AIDSLINE MED/95035666
Wu TC; Division of Antiviral Drug Products, U.S. Food and Drug; Administration, Rockville, Maryland 20857.
As medical advances have prolonged the lives of patients with cancer, recipients of organ transplants, and patients with AIDS, there has been a marked increase in the number of fungal infections. Because of the known toxicity associated with amphotericin B, which has been the mainstay of therapy for systemic fungal in


Evidence for an altered T-cell receptor repertoire in Crohn's disease.
Autoimmunity. 1994;17(4):301-7. Unique Identifier : AIDSLINE MED/95035716
Shalon L; Gulwani-Akolkar B; Fisher SE; Akolkar PN; Panja A; Mayer L; Silver J; Department of Pediatrics, North Shore University Hospital-Cornell; University Medical College, Manhasset, N.Y. 11030.
We have compared the frequencies of T cells expressing each of four different T cell receptor (TCR) V beta segments in lamina propria and peripheral blood lymphocytes of 12 Crohn s disease (CD), six ulcerative colitis (UC), and 10 control patients in an attempt to identify disease-specific changes. The frequencies of


Development of a ceramic matrix system for continuous delivery of azidothymidine.
Biomed Sci Instrum. 1994;30:181-6. Unique Identifier : AIDSLINE MED/95035738
Nagy EA; Bajpai PK; Honors Program, University of Dayton, OH 45469-2320.
A beta-tricalcium phosphate (TCP) ceramic system was designed to deliver azidothymidine ( AZT ) in an aqueous medium (phosphate buffered saline pH 7.4) at 37 degrees C. Since AZT is an analog of thymidine, initial studies were conducted with thymidine.


Molecular dynamics studies of the human CD4 protein.
Biopolymers. 1994 Sep;34(9):1145-53. Unique Identifier : AIDSLINE MED/95035840
Ptaszek LM; Vijayakumar S; Ravishanker G; Beveridge DL; Department of Chemistry, Wesleyan University, Middletown,; Connecticut 06459.
A dynamical model for an N-terminal fragment of the human CD4 protein has been determined by computer simulation. The protein has been studied both in vacuo and in solution. Data from both simulations agree moderately well with each other and with the crystal structure. All elements of secondary structure were retaine


Apoptosis: programmed cell death in health and disease.
Biosci Rep. 1994 Apr;14(2):67-81. Unique Identifier : AIDSLINE MED/95035887
Bright J; Khar J; Khar A; Centre for Cellular and Molecular Biology, Hyderabad, India.
Apoptosis is a normal physiological cell death process of eliminating unwanted cells from living organisms during embryonic and adult development. Apoptotic cells are characterised by fragmentation of nuclear DNA and formation of apoptotic bodies. Genetic analysis revealed the involvement of many death and survival ge


Activation of microglia in HIV-1 infected brains is not dependent on the presence of HIV-1 antigens.
Neuroreport. 1994 Jul 21;5(12):1514-6. Unique Identifier : AIDSLINE MED/95035973
Weis S; Neuhaus B; Mehraein P; Institute of Neuropathology, Ludwig-Maximilians University; Munich, Germany.
The activation pattern of microglia in the cerebral cortex of AIDS patients with the neuropathological diagnosis of HIV-1 encephalitis was investigated by immunohistochemistry and morphometry. The number of activated microglial cells in the grey and white matter of five cortical regions was determined. In the grey and


Central nervous system toxoplasmosis in the AIDS patient.
J Assoc Nurses AIDS Care. 1994 Jul-Aug;5(4):14-8, 27; quiz 19-20. Unique Identifier : AIDSLINE MED/95036098
Cassidy CM; San Francisco General Hospital.
Toxoplasmosis is a central nervous system infection commonly occurring in persons with HIV disease. The disease can manifest as encephalitis and cause neurological damage. The author presents an overview of the epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of toxoplasmosis. The nurse s


Ethnography and AIDS: a methodology for identifying culturally relevant risk-reducing behaviors.
J Assoc Nurses AIDS Care. 1994 Jul-Aug;5(4):21-7. Unique Identifier : AIDSLINE MED/95036099
Cruise PL; Dunn SM; School of Public Administration, Florida Atlantic University, Ft.; Lauderdale.
As the AIDS pandemic enters its second decade, persons most at risk for developing the disease are low-income African-American women and their children. This group has been extremely difficult to reach with traditional top-down risk reduction programs developed by the federal government. The authors describe an ethnog


Wellness spirituality in homosexual men with HIV infection.
J Assoc Nurses AIDS Care. 1994 Jul-Aug;5(4):28-34. Unique Identifier : AIDSLINE MED/95036100
Kendall J; Oregon Health Sciences University School of Nursing, Portland.
The concept of wellness as a spiritual process is examined in this grounded theory study on the role of human relationships in the well-being of gay men with HIV infection. The sample included 29 homosexual men in various stages of HIV illness. Findings reveal a description of the construct, wellness spirituality, in


Megestrol acetate oral suspension.
J Assoc Nurses AIDS Care. 1994 Jul-Aug;5(4):35-6, 44. Unique Identifier : AIDSLINE MED/95036101
Porche DJ
HIV/AIDS clients' satisfaction with selected aspects of clinic nursing services.
J Assoc Nurses AIDS Care. 1994 Jul-Aug;5(4):37-44. Unique Identifier : AIDSLINE MED/95036102
Meeks-Festa L; Uhle SM; Munjas B; Gerszten E; Creger A; Medical College of Virginia Hospital, Richmond.
The authors report findings from a semistructured interview study of a random sample of adult clients (N = 20) receiving care in the infectious disease clinic at a large university-affiliated state-supported teaching hospital. Clients were asked to respond to items designed to measure their satisfaction with nursing a


Single and double drug susceptibility testing of Mycobacterium avium complex and mycobacteria other than the tubercle (MOTT) bacilli by a micro-dilution broth minimum inhibitory concentration (MIC) method.
Tuber Lung Dis. 1994 Aug;75(4):286-90. Unique Identifier : AIDSLINE MED/95036207
Telles MA; Yates MD; Setor de Micobacterias, Instituto Adolfo Lutz, Sao Paulo, Brasil.
SETTING: The incidence of Mycobacterioses is increasing annually, especially in patients with AIDS. There is no clear correlation between in vitro drug susceptibility testing of mycobacteria other than the tubercle (MOTT) bacilli and the in vivo response. Although in vitro, MOTT bacilli appear resistant, some patients


HIV infection and tuberculosis: an epidemiological study from a French register.
Tuber Lung Dis. 1994 Aug;75(4):291-6. Unique Identifier : AIDSLINE MED/95036208
Liard R; Harf R; Korobaeff M; Schwoebel V; Neukirch F; INSERM U 226, Paris, France.
SETTING: The possible impact of the human immunodeficiency virus (HIV) infection on the epidemiology of tuberculosis has never been studied in a general French population. OBJECTIVE: To describe the evolution of tuberculosis incidence from 1983 to 1991 in a French district (Rhone) and to assess its relationships to HI


Tuberculous pericardial effusion associated with HIV infection: a sign of disseminated disease.
Tuber Lung Dis. 1994 Aug;75(4):297-300. Unique Identifier : AIDSLINE MED/95036209
Pozniak AL; Weinberg J; Mahari M; Neill P; Houston S; Latif A; Department of Medicine, University of Zimbabwe, Harare.
OBJECTIVE: To determine whether tuberculous pericardial effusion is associated with HIV infection. DESIGN: Retrospective cohort study. SETTING: Harare, Zimbabwe . SUBJECTS: 61 consecutive patients presenting with tuberculous pericarditis over an 18 month period. RESULTS: Tuberculo


Nocardiosis in HIV-positive patients: an autopsy study in West Africa.
Tuber Lung Dis. 1994 Aug;75(4):301-7. Unique Identifier : AIDSLINE MED/95036210
Lucas SB; Hounnou A; Peacock C; Beaumel A; Kadio A; De Cock KM; Department of Histopathology, University College London Medical; School, UK.
BACKGROUND: There are many reports of nocardiosis associated with HIV infection in industrialized and developing countries, but its true prevalence is unknown. MATERIALS AND METHODS: An autopsy study was performed of HIV-positive and HIV-negative patients dying on the general medical wards of a large hospital in Abidj


Community acquired pneumonia in adults in Addis Ababa: etiologic agents and the impact of HIV infection.
Tuber Lung Dis. 1994 Aug;75(4):308-12. Unique Identifier : AIDSLINE MED/95036211
Aderaye G; Department of Internal Medicine, Addis Ababa University,; Ethiopia.
SETTING: Black Lion Hospital, a tertiary care referral hospital in Addis Ababa, Ethiopia . OBJECTIVE: To determine the prevalence of HIV infection in patients with Community Acquired Pneumonia (CAP) and compare the etiologic agents, clinical and radiographic presentation and outco


Mycobacterium kansasii infection presenting as an endobronchial tumor in a patient with the acquired immune deficiency syndrome.
Tuber Lung Dis. 1994 Aug;75(4):313-5. Unique Identifier : AIDSLINE MED/95036212
Quieffin J; Poubeau P; Laaban JP; Brechot JM; Capron F; Rochemaure J; Department of Respiratory Medicine and Intensive Care,; Hotel-Dieu Hospital, Paris, France.
We report a case of Mycobacterium kansasii endobronchial infection presenting as a tumor obstructing 2 segmental bronchi in a patient with the acquired immune deficiency syndrome. Biopsies of the lesions revealed granuloma with acid-fast organisms. Culture grew M. kansasii. To our knowledge, this is the first case of


Syngeneic adoptive transfer of anti-human immunodeficiency virus (HIV-1)-primed lymphocytes from a vaccinated HIV-seronegative individual to his HIV-1-infected identical twin.
Blood. 1994 Nov 15;84(10):3317-26. Unique Identifier : AIDSLINE MED/95036224
Bex F; Hermans P; Sprecher S; Achour A; Badjou R; Desgranges C; Cogniaux J; Franchioli P; Vanhulle C; Lachgar A; et al; Department of Molecular Biology, University of Brussels, Belgium.
Immunotherapy by adoptive transfer of lymphocytes was attempted in identical twins, one who was virus-free and the other who was infected with human immunodeficiency virus-1 (HIV-1), at the stage of acquired immunodeficiency syndrome. The noninfected twin was vaccinated by priming with a recombinant vaccinia virus exp


Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice.
Blood. 1994 Nov 15;84(10):3540-9. Unique Identifier : AIDSLINE MED/95036251
Fowler DH; Kurasawa K; Smith R; Eckhaus MA; Gress RE; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.
We have recently shown that donor CD4-enriched cells of Th2 cytokine phenotype, generated by treating mice in vivo with a combination of interleukin-2 ( IL-2 ) and IL-4, prevent lipopolysaccharide-induced, tumor necrosis factor-alpha-mediated lethality during graft-versu


Monoclonal antibodies directed against the Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1): immunohistologic detection of EBNA1 in the malignant cells of Hodgkin's disease.
Blood. 1994 Dec 1;84(11):3792-8. Unique Identifier : AIDSLINE MED/95036287
Grasser FA; Murray PG; Kremmer E; Klein K; Remberger K; Feiden W; Reynolds G; Niedobitek G; Young LS; Mueller-Lantzsch N; Abteilung Virologie, Universitatskliniken des Saarlandes,; Homburg, Germany.
Monoclonal antibodies directed against the Epstein-Barr virus nuclear protein 1 (EBNA1) were used to examine conventional paraffin sections from a series of EBV-associated lymphoproliferative disorders by immunohistochemistry. The presence of latent EBV infection in tumor cells was determined by in situ hybridization


CD30 antigen and cellular biology of Reed-Sternberg cells [letter; comment]
Blood. 1994 Dec 1;84(11):3983-4. Unique Identifier : AIDSLINE MED/95036313
Pizzolo G; Vinante F; Chilosi M; Romagnani S; Del Prete G
Targeting of human immunodeficiency virus-infected cells by CD8+ T lymphocytes armed with universal T-cell receptors.
Blood. 1994 Nov 1;84(9):2878-89. Unique Identifier : AIDSLINE MED/95036321
Roberts MR; Qin L; Zhang D; Smith DH; Tran AC; Dull TJ; Groopman JE; Capon DJ; Byrn RA; Finer MH; Cell Genesys Inc, Foster City, CA.
We have developed an immunotherapeutic approach with potential application in the treatment of viral and malignant disease. We show that primary CD8+ T cells isolated from peripheral blood can be genetically modified by retroviral transduction to express high levels of universal (major histocompatibility complex-unres


Transcriptional regulation of the human interleukin-6 gene promoter in human T-cell leukemia virus type I-infected T-cell lines: evidence for the involvement of NF-kappa B.
Blood. 1994 Nov 1;84(9):2904-11. Unique Identifier : AIDSLINE MED/95036324
Mori N; Shirakawa F; Shimizu H; Murakami S; Oda S; Yamamoto K; Eto S; First Department of Internal Medicine, School of Medicine,; University of Occupational and Environmental Health, Kitakyushu,; Japan.
Freshly isolated leukemic cells from patients with adult T-cell leukemia (ATL) and human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines constitutively produce high levels of interleukin-6 (IL-6) protein and mRNA. To clarify the mechanisms that lead to the activation of IL-6 gene in HTLV-I-infected cells,


A novel diagnostic method of adult T-cell leukemia: monoclonal integration of human T-cell lymphotropic virus type I provirus DNA detected by inverse polymerase chain reaction.
Blood. 1994 Nov 1;84(9):3080-5. Unique Identifier : AIDSLINE MED/95036348
Takemoto S; Matsuoka M; Yamaguchi K; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; School of Medicine, Japan.
Adult T-cell leukemia (ATL) is neoplasm of the mature helper T lymphocytes and human T-cell lymphotropic virus type-I (HTLV-I) has been shown to be causative virus of ATL. Because HTLV-I integrates its provirus randomly into host chromosomal DNA, monoclonal integration of HTLV-I provirus indicates the clonal prolifera


[Chagas' disease among blood donors in Bolivia]
Nippon Koshu Eisei Zasshi. 1994 Oct;41(10):1027-31. Unique Identifier : AIDSLINE MED/95036483
Miyoshi C; Tanabe M; Kawai S; Honda S; Sakuma F; Katayama T; Rojas E; Rosado D; Bureau of International Cooperation, International Medical Center; of Japan.
A questionnaire survey of blood donors at Santa Cruz General Hospital, Bolivia , showed that while there were no seropositive cases of syphilis, HBsAg, and HIV, the prevalence of Chagas disease was very high (23%) among the 225 blood donors who responded to this questionnaire. Act


Keloidal Kaposi's sarcoma: report of three patients.
Dermatology. 1994;189(3):271-4. Unique Identifier : AIDSLINE MED/95036758
Schwartz RA; Spicer MS; Janniger CK; Cohen PJ; Melczer MM; Lambert WC; New Jersey Medical School, Newark 07103-2714.
Kaposi s sarcoma is a unique neoplasm which has emerged as an important element of AIDS in homosexuals but not in others at high risk for AIDS. The biology of this important tumor may be related to cytokines secreted by HIV-infected cells and/or by Kaposi s sarcoma cells themselves. We report 3 patients with multiple


Mucocutaneous leishmaniasis and HIV.
Dermatology. 1994;189(3):275-7. Unique Identifier : AIDSLINE MED/95036759
Miralles ES; Nunez M; Hilara Y; Harto A; Moreno R; Ledo A; Servicio de Dermatologia, Universidad de Alcala de Henares,; Hospital Ramon y Cajal, Madrid, Spain.
Mucocutaneous leishmaniasis is a rare disease in Europe. Relapses after treatment are more frequent than in visceral leishmaniasis. HIV patients infected by Leishmania have frequently visceral involvement, and responses to treatment are poor. Mucocutaneous leishmaniasis in HIV-infected patients has rarely been reporte


Pigmentation of Peutz-Jeghers syndrome occurring in psoriatic plaques.
Dermatology. 1994;189(3):297-300. Unique Identifier : AIDSLINE MED/95036765
McKenna KE; Walsh MY; Burrows D; Department of Dermatology, Royal Victoria Hospital, Belfast, UK.
We report a patient with late-onset mucocutaneous pigmentation characteristic of Peutz-Jeghers syndrome, who also developed hyperpigmented macules within pre-existing psoriatic plaques. This has rarely been reported. Macular pigmentation of the forehead and dorsum of the fingers was also a prominent feature. It is imp


Concurrent use of foscarnet and ciprofloxacin may increase the propensity for seizures.
Ann Pharmacother. 1994 Jul-Aug;28(7-8):869-72. Unique Identifier : AIDSLINE MED/95036778
Fan-Harvard P; Sanchorawala V; Oh J; Moser EM; Smith SP; Rutgers College of Pharmacy, Piscataway, NJ.
OBJECTIVE: To report a possible interaction between foscarnet and ciprofloxacin in two patients with AIDS, cytomegalovirus ( CMV ) retinitis, and disseminated Mycobacterium avium complex (MAC) infection and to review the availa


Early single-photon emission computed tomography in mild head trauma. A controlled study.
J Neuroimaging. 1994 Oct;4(4):177-81. Unique Identifier : AIDSLINE MED/95036833
Masdeu JC; Van Heertum RL; Kleiman A; Anselmi G; Kissane K; Horng J; Yudd A; Luck D; Grundman M; Department of Neurology, St. Vincent's Hospital and Medical; Center of New York, NY 10011.
Although computed tomography (CT) and magnetic resonance imaging scans often appear normal after mild head trauma, many patients experience attentional or other cognitive disturbances that are difficult to quantify by neuropsychological testing in the absence of a premorbid profile. Within 2 days of mild head trauma,


Temporal alterations of immunohistochemical findings in polymyositis.
Intern Med. 1994 May;33(5):263-70. Unique Identifier : AIDSLINE MED/95036937
Tajima Y; Moriwaka F; Tashiro K; Department of Neurology, Hokkaido University School of Medicine,; Sapporo.
To investigate the pathological mechanisms of polymyositis, we performed immunohistochemical analyses with biopsied muscles. Comparative studies using specimens obtained from the same patient enabled us to analyze the pathological alterations at different sequential clinical phases without taking into account each imm


A computer-based interview to identify HIV risk behaviors and to assess patient preferences for HIV-related health states.
Proc Annu Symp Comput Appl Med Care. 1994;:20-4. Unique Identifier : AIDSLINE MED/95037239
Sanders GD; Owens DK; Padian N; Cardinalli AB; Sullivan AN; Nease RF; Department of Veterans Affairs Medical Center, Palo Alto, CA.
We developed a computer-based utility assessment tool to assess the preferences of patients towards HIV-related health states and identify risk behaviors (both sexual and drug related) of the patient being interviewed. The reliability of the computer-based interview was assessed through comparison with person-to-perso


The use and impact of a computer-based support system for people living with AIDS and HIV infection.
Proc Annu Symp Comput Appl Med Care. 1994;:604-8. Unique Identifier : AIDSLINE MED/95037319
Gustafson DH; Hawkins RP; Boberg EW; Bricker E; Pingree S; Chan CL; Center for Health Systems Research and Analysis, University of; Wisconsin, Madison.
CHESS (the Comprehensive Health Enhancement Support System) is an interactive, computer-based system to support people facing AIDS/HIV Infection and other health-related crises or concerns. CHESS provides information, referral to service providers, support in making tough decisions and networking to experts and others


Liposomal doxorubicin in AIDS-related Kaposi's sarcoma: long-term experiences.
Clin Investig. 1994 Jun;72(6):417-23. Unique Identifier : AIDSLINE MED/95037472
Wagner D; Kern WV; Kern P; Sektion Infektiologie und Klinische Immunologie, Medizinische; Universitatsklinik und Poliklinik, Ulm, Germany.
Treatment of AIDS-related Kaposi s sarcoma with cytotoxic chemotherapy is limited by toxicities of the various agents. Liposomal doxorubicin is a new treatment option for patients with Kaposi s sarcoma with potentially reduced toxicity. Three AIDS patients with different stages of tumor risk were enrolled in a study e


[Correlation between serum adenosine deaminase, peripheral T lymphocyte subsets and syndrome types of traditional Chinese medicine in liver-cirrhosis patients]
Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 Mar;14(3):148-9, 132. Unique Identifier : AIDSLINE MED/95037504
Deng YQ; Dept. of TCM, 1st Affiliated Hospital, Zhejiang Medical Univ.,; Hangzhou.
Serum adenosine deaminase (ADA) of 74 liver cirrhosis patients and 100 healthy subjects as control were examined with improved Martinek microassay and peripheral T lymphocyte subsets of 38 liver cirrhosis patients and 60 healthy subjects studied by indirect immunofluorescence assay (IFA) for exploring the relationship


[Progress of experimental study on infantile recurrent respiratory infection]
Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 Mar;14(3):184-6. Unique Identifier : AIDSLINE MED/95037513
Zhu SC
[Recent development and prospect of Trichosanthin for clinical application]
Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 May;14(5):319-20. Unique Identifier : AIDSLINE MED/95037542
Zang LJ
[Studies of guben quyu No I combined with chemotherapy in treating cancer]
Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 Jul;14(7):392-5. Unique Identifier : AIDSLINE MED/95037543
Yu RC; Peng XM; Rao XQ; Beijing Hospital of TCM.
Cancer patients with Qi-Deficiency and Blood Stasis (QDBS) syndrome were studied, and stress was put on the observation of the Guben Quyu No. I, which was used in combining with chemotherapy for synergistic effect and attenuation of toxicity. The results: QDBS syndrome often existed in cancer patients, and chemotherap


[Clinical study in treating intractable ulcerative colitis with traditional Chinese medicine]
Chung Kuo Chung Hsi I Chieh Ho Tsa Chih. 1994 Jul;14(7):400-2. Unique Identifier : AIDSLINE MED/95037545
Chen ZS; Nie ZW; Sun QL; 211 Hospital of PLA, Harbin.
Clinical double blind study in treating 153 intractable ulcerative colitis with Chinese medicinal herbs was conducted, the patients were randomly assigned to three groups. Group I is administered with Jian Pi Ling (JPL) tablet with retention-enema of Radix Sophorae Flavescentis and Flos Sophora (RSF-FS) decoction per


Managing change to improve outpatient care.
Br J Nurs. 1994 Oct 27-Nov 9;3(19):1005-11. Unique Identifier : AIDSLINE MED/95037593
Harrow T; Lempp H; McDermott S
By establishing a quality circle and involving clients it is possible to improve many aspects of outpatient care in the multidisciplinary clinic. This article describes the ramifications of change within the multidisciplinary team and offers some suggestions for setting up similar groups in the inpatient, outpatient o


[Prevention of Rhesus incompatibility and viral safety]
Infusionsther Transfusionsmed. 1994 Aug;21(4):281-3. Unique Identifier : AIDSLINE MED/95037617
Kirchebner C; Solder E; Schonitzer D; Zentralinstitut fur Bluttransfusion und Immunologische; Abteilung, Universitatskliniken Innsbruck.
Sporadic reports on hepatitis-B and NANB transmissions via intravenous immunoglobulin preparations (ivIg) and a series of NANB cases after administration of intramuscular immunoglobulin (imIg) for prophylaxis of immunisation against the Rhesus (Rh) antigen D (imIg-D) in the former Eastern


Educating bisexual men about HIV risk [news]
Can Fam Physician. 1994 Oct;40:1870-1. Unique Identifier : AIDSLINE MED/95037826
Ketchum P
How to lose the fight against AIDS among gay men [editorial]
BMJ. 1994 Sep 17;309(6956):685-6. Unique Identifier : AIDSLINE MED/95037899
Stall R
US AIDS activists urge caution on new anti-HIV drugs [news]
BMJ. 1994 Sep 24;309(6957):757. Unique Identifier : AIDSLINE MED/95037943
Roberts J
Knowledge about tests for HIV antibodies among pregnant women [letter]
BMJ. 1994 Oct 1;309(6958):877. Unique Identifier : AIDSLINE MED/95038038
Desmond N; Morgan H; Kell P
Using CD4 lymphocyte count to predict survival with HIV infection [letter; comment]
BMJ. 1994 Oct 1;309(6958):877. Unique Identifier : AIDSLINE MED/95038040
Harindra V
European Union tries to control disease [news]
BMJ. 1994 Oct 22;309(6961):1039. Unique Identifier : AIDSLINE MED/95038157
Watson R
AIDS-related cholangiopancreatographic changes [see comments]
Abdom Imaging. 1994 Sep-Oct;19(5):417-22. Unique Identifier : AIDSLINE MED/95038242
Farman J; Brunetti J; Baer JW; Freiman H; Comer GM; Scholz FJ; Koehler RE; Laffey K; Green P; Clemett AR; Department of Radiology, Columbia-Presbyterian Medical Center,; New York, NY 10032-3284.
The cholangiographic and pancreatographic appearances of the acquired immunodeficiency syndrome (AIDS) associated cholangitis were evaluated in 26 patients. Twenty-four patients were diagnosed by retrograde cholangiography or endoscopic cholangiopancreatography (ERC or ERCP). One patient was diagnosed by T-tube cholan


AIDS-related manifestations of the bile duct system: a common finding? [editorial; comment]
Abdom Imaging. 1994 Sep-Oct;19(5):423-4. Unique Identifier : AIDSLINE MED/95038243
Reeders JW; Bartelsman JF; Huibregtse K
Correlates of sexual risk-taking among gay male substance abusers.
Addiction. 1994 Aug;89(8):971-83. Unique Identifier : AIDSLINE MED/95038289
Paul JP; Stall RD; Crosby GM; Barrett DC; Midanik LT; Center for AIDS Prevention Studies, University of California, San; Francisco 94143.
This paper examines sexual risk-taking within a sample of sexually active gay and bisexual men entering substance abuse treatment (n = 383), and identifies correlates of unprotected anal sex within this group. Sexual risk-taking was high, with 55% of these men engaging in anal intercourse without a condom within a 90-


Exploration of mucosal immunity in humans: relevance to vaccine development.
Cell Mol Biol (Noisy-le-grand). 1994;40 Suppl 1:37-44. Unique Identifier : AIDSLINE MED/95038296
Czerkinsky C; Holmgren J; INSERM Unit 80, Hopital Edouard-Herriot, Lyon, France.
Although the immune system is remarkably diverse, there is evidence that certain types of immune responses take place and are restricted to certain anatomic locations within the body. The concept of a common mucosal immune system that provides immune reactivity not only at the site of antigen deposition but also at re


Virus-specific cytotoxic T lymphocyte responses in patients infected with the human immunodeficiency virus, HIV-1.
Cell Mol Biol (Noisy-le-grand). 1994;40 Suppl 1:45-8. Unique Identifier : AIDSLINE MED/95038297
Riviere Y; Unite de Virologie et Immunologie Cellulaire, Institut Pasteur,; Paris, France.
A vigorous virus-specific cytotoxic response has been detected in individuals infected by the human immunodeficiency virus (HIV). ADCC and CTL activities specific to the envelope glycoproteins could be measured at the same time from the same donor. CTL response have been shown directed to most viral structural and non


Phase I trial of a genetically engineered interleukin-2 fusion toxin (DAB486IL-2) as a 6 hour intravenous infusion in patients with hematologic malignancies.
Leuk Lymphoma. 1994 Jul;14(3-4):257-62. Unique Identifier : AIDSLINE MED/95038360
Platanias LC; Ratain MJ; O'Brien S; Larson RA; Vardiman JW; Shaw JP; Williams SF; Baron JM; Parker K; Woodworth TG; Department of Medicine, University of Chicago, Pritzker School of; Medicine, Illinois.
DAB486IL-2 is a recombinant fusion toxin, created by replacement of the receptor binding domain sequences of the diphtheria toxin gene with the sequences for human interleukin-2 (IL-2). It selectively binds to and intoxicates cells expressing the high-affinity IL-2 receptor. A total of 17 patients with refractory hema


Infusional cyclophosphamide, doxorubicin and etoposide in HIV-related non-Hodgkin's lymphoma: a follow-up report of a highly active regimen.
Leuk Lymphoma. 1994 Jul;14(3-4):263-71. Unique Identifier : AIDSLINE MED/95038361
Sparano JA; Wiernik PH; Strack M; Leaf A; Becker NH; Sarta C; Carney D; Elkind R; Shah M; Valentine ES; et al; Department of Oncology, Albert Einstein Cancer Center, Montefiore; Medical Center, Bronx, NY 10467.
Based on our prior data suggesting a therapeutic advantage for infusional administration of cyclophosphamide (C), doxorubicin (D), and etoposide (E) in patients with relapsed and resistant non-Hodgkin s lymphoma (NHL), we administered C (750 mg/m2), D (50 mg/m2), and E (240 mg/m2)


Burkitt's lymphoma in Turkish children: clinical, viral [EBV] and molecular studies.
Leuk Lymphoma. 1994 Jul;14(3-4):323-30. Unique Identifier : AIDSLINE MED/95038369
Cavdar AO; Yavuz G; Babacan E; Gozdasoglu S; Unal E; Ertem U; Pamir A; Yucesan S; Gokcora H; Uluoglu O; et al; Pediatric Hematology and Oncology Research Center, Ankara; University, Turkey.
Eighty-one Turkish children with Burkitt s lymphoma (BL) were observed during a period of 24 years (1968-1992). The diagnosis was established histologically according to WHO criteria. BL represented 48.5% of NHL in this series. The median age of patients was 5 years with a sex (M/F) ratio of 2.3/1. The most common pri


Prostatic tuberculosis and AIDS.
Natl Med J India. 1994 Jul-Aug;7(4):166-7. Unique Identifier : AIDSLINE MED/95038396
Lanjewar DN; Maheshwari MB; Grant Medical College, Sir J. J. Group of Hospitals, Maharashtra,; India.
Tuberculosis of the prostate is rare and is thought to be either due to haematogenous dissemination or secondary to renal infection. We describe, possibly for the first time, two male patients with the acquired immunodeficiency syndrome who had tuberculous abscesses in the prostate discovered at post-mortem examinatio


Sex education in Indian schools [letter]
Natl Med J India. 1994 Jul-Aug;7(4):194-5. Unique Identifier : AIDSLINE MED/95038406
Singh S
Kaposi's sarcoma of the foot in the HIV patient.
J Foot Ankle Surg. 1994 Jul-Aug;33(4):341-5. Unique Identifier : AIDSLINE MED/95038688
Montes C; Luepschen OM; Schmall L; Gomez RR; Department of Podiatry, Westchester General Hospital, Miami,; Florida.
The authors present up-to-date information on AIDS-related Kaposi s sarcoma. Etiology, classifications, histopathology, evaluation, and treatment of the condition are discussed, with a clinical case study presented. The authors stress increased awareness by the podiatrist in the diagnosis and treatment of Kaposi s sar


A model-based approach to estimate the AIDS-free time distribution in homosexual men using longitudinal data.
J Biopharm Stat. 1994 Jul;4(2):129-46. Unique Identifier : AIDSLINE MED/95038782
Dunlop DD; Tamhane AC; Chmiel JS; Phair JP; Center for Health Services and Policy Research, Northwestern; University, Evanston, Illinois 60208.
A model-based approach is developed to estimate the distribution of time from seroconversion to diagnosis with acquired immunodeficiency syndrome (AIDS) as a function of selected time-dependent covariates. The approach is applied to longitudinal data collected over 4 years of follow-up from 450 men seropositive for th


HIV induced systemic lupus erythematosus [letter]
Lupus. 1994 Jun;3(3):205-6. Unique Identifier : AIDSLINE MED/95038822
Itoh K; Nishioka Y; Hirohata S; Inoue T; Ito K; Kimura M; Mori S
Are human genes risk factors for AIDS? [news]
Nat Genet. 1994 Aug;7(4):456-7. Unique Identifier : AIDSLINE MED/95038826
Louie LG
Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep naturally infected by the visna-maedi virus.
Vet Res. 1994;25(5):478-88. Unique Identifier : AIDSLINE MED/95038885
Mornex JF; Lena P; Loire R; Cozon G; Greenland T; Guigen F; Jacquier MF; Cordier G; Laboratoire d'Immunologie et de Biologie Pulmonaire: INSERM CJF; 93-08, Hopital Louis-Pradel, Lyon, France.
Visna-maedi virus is a lentivirus that causes a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar to that in man associated with the infection by the human immunodeficiency virus type-1. We have compared the pathological features of lungs of sheep naturally infected


Modeling the HIV/AIDS epidemic in the English-speaking Caribbean.
Bull Pan Am Health Organ. 1994 Sep;28(3):239-49. Unique Identifier : AIDSLINE MED/95038908
Newton EA; White FM; Sokal DC; King TD; Forsythe SS; Caribbean Epidemiology Center, Trinidad, West Indies.
The study reported here examines the past and potential future impact of HIV/AIDS in 19 nations of the primarily English-speaking Caribbean. The authors use DemProj, a demographic projection model, to explore two different HIV scenarios. In the low scenario adult HIV prevalence stabilizes at 2% in the year 2000, and i


Technical advisory meeting held on newly identified HIV-1 subtype O viruses [news]
Bull Pan Am Health Organ. 1994 Sep;28(3):282-3. Unique Identifier : AIDSLINE MED/95038911
Study: HIV risks low for health care workers [news]
Hosp Health Netw. 1994 Nov 5;68(21):17. Unique Identifier : AIDSLINE MED/95038964
Intravenous methylprednisolone pulse therapy for Graves' ophthalmopathy.
Endocr J. 1993 Feb;40(1):63-72. Unique Identifier : AIDSLINE MED/95039056
Hiromatsu Y; Tanaka K; Sato M; Kuroki T; Nonaka K; Kojima K; Nishimura H; Nishida H; Kaise N; Department of Medicine, Kurume University School of Medicine,; Fukuoka, Japan.
To investigate the efficacy of intravenous methylprednisolone pulse therapy on Graves ophthalmopathy (GO), fifteen patients with severe GO were treated with large dose intravenous methylprednisolone (at a daily dosage of 1 g for 3 successive days). This treatment was repeated 3-5 times for 3-5 weeks. They were monito


Adrenal insufficiency in a patient with acquired immunodeficiency syndrome.
Endocr J. 1994 Feb;41(1):13-8. Unique Identifier : AIDSLINE MED/95039109
Fujii K; Morimoto I; Wake A; Okada Y; Inokuchi N; Ishida O; Nakano Y; Oda S; Eto S; First Department of Internal Medicine, University of Occupational; and Environmental Health, Kitakyushu, Japan.
A 46-year-old man was admitted because of hypotension and consciousness disturbance. He was a patient with hemophilia B, and diagnosed as having an AIDS-related complex 2 years prior to admission. On admission he had severe hyponatremia. Hormonal studies revealed that he had Addison s disease. Serum


[Heterosexual transmission of HIV infection]
Contracept Fertil Sex. 1993 Feb;21(2):145-8. Unique Identifier : AIDSLINE MED/95039169
Coulaud JP; Institut medecine et d'epidemiologie africaines (Fondation; Leon Mba), Paris.
HIV heterosexual transmission is very common in Africa and is overgrowing in western countries. Heterosexual transmission is facilitated by the severity of immunosuppression in contaminating patients, by previous STD, by anal intercourse and age over 45 years in females, by sexual intercourses during menses in males.


[HIV seropositivity and desire for children]
Contracept Fertil Sex. 1993 Mar;21(3):217-21. Unique Identifier : AIDSLINE MED/95039181
Henrion R; Mandelbrot L; Firtion G; Cremieux N; Henrion-Geant E; Clinique Universitaire Port-Royal, Paris.
Growing numbers of women and men who are HIV infected and aware of their serostatus, want to have children. Gynecologists are involved in the dilemmas of counseling those couples about reproductive decisions. For HIV infected women, pregnancy is contra-indicated, mostly because of the risk of transmission to the fetus


[Voluntary screening of AIDS]
Contracept Fertil Sex. 1993 Mar;21(3):267-8. Unique Identifier : AIDSLINE MED/95039191
Merger C; Geraud R
Changing adolescents' HIV-related attitudes and behaviors: the challenge and the opportunity.
Curr Opin Pediatr. 1994 Aug;6(4):428-33. Unique Identifier : AIDSLINE MED/95039250
Brown LK; Lourie KJ; Brown University, Providence, Rhode Island.
Most teenagers have basic knowledge about HIV, although misconceptions about the safety of venipuncture and blood donation persist. By high school age, over half of teens nationally report having had sexual intercourse. Despite adequate knowledge and good intentions to stay safe, which are reinforced by widespread HIV


Activated peripheral blood CD4 and CD8 T-lymphocytes in child asthma: correlation with eosinophilia and disease severity.
Pediatr Allergy Immunol. 1994 Aug;5(3):170-7. Unique Identifier : AIDSLINE MED/95039353
Gemou-Engesaeth V; Kay AB; Bush A; Corrigan CJ; Department of Allergy & Clinical Immunology, National Heart &; Lung Institute, London, England.
There now exists compelling evidence of a role for cell-mediated immunity in the pathogenesis of adult asthma, but little information is available as to what extent this process participates in the pathogenesis of childhood asthma. We hypothesised that asthma in children is associated with the activation of T-lymphocy


[Methodological approaches to the analysis of postradiation impairment of lympho- and hematopoiesis]
Radiats Biol Radioecol. 1994 Jul-Oct;34(4-5):467-73. Unique Identifier : AIDSLINE MED/95039570
Miroshnichenko IV; Riabinina ID; Sharova NI; Mal'tseva VV; Stolpnikova VN; Kochergina NI
Human intrathymic precursors are characterized by mitogenic reaction on thymic hormone, lacking the cortical and medullar thymic membrane markers (CD3, CD4 and/or CD8) and expressing of the common T-cell CD7 and CD5 antigens. Fraction 1.062 g/cm3 of peripheral white blood cells contains cells with analogous characteri


[Clinico-immunological characteristics of people who worked within the 30-kilometer zone of the accident at the Chernobyl Atomic Power Plant 4 years after the accident]
Radiats Biol Radioecol. 1994 Jul-Oct;34(4-5):611-9. Unique Identifier : AIDSLINE MED/95039591
Oradovskaia IV; Ruzybakiev RM; Prokopenko VD; Dmitriev AL; Zakharov GA; Androsov VN; Podobin NN; Mirkamalova LI; Askarova LI; Sevast'ianova EV; et al
Clinical examination with immune status assessment of more than 300 healthy persons, who worked in 30-km Chernobyl NPP zone four years after the accident was carried out. The clinical characters of immune deficiency were detected in 6.67% of examined persons and appeared as repeated respiratory diseases. Significant i


Neuro-ophthalmology and systemic disease. An annual review (1993).
J Neuroophthalmol. 1994 Jun;14(2):105-17. Unique Identifier : AIDSLINE MED/95039627
Newman NJ; Department of Ophthalmology, Emory University School of Medicine,; Atlanta, Georgia.
Successfully treated optic nerve infiltration with adult T-cell lymphoma.
J Neuroophthalmol. 1994 Jun;14(2):81-3. Unique Identifier : AIDSLINE MED/95039632
Yamamoto N; Kiyosawa M; Kawasaki T; Miki T; Fujino T; Tokoro T; Department of Ophthalmology, Tokyo Medical and Dental University,; Japan.
A 45-year-old woman with adult T-cell leukemia had a sudden onset of decreased vision with central scotoma in the right eye. Right optic disc edema and thickening of the optic nerve were observed by magnetic resonance imaging. A diagnosis of leukemic infiltration to the optic nerve was made. A course of oral corticost


Production and simple purification of a protein encoded by part of the gag gene of HIV-1 in the Escherichia coli HB101F+ expression system inducible by lactose and isopropyl-beta-D-thiogalactopyranoside.
J Chromatogr B Biomed Appl. 1994 Jun 3;656(1):127-33. Unique Identifier : AIDSLINE MED/95039724
Liska V; Dyr JE; Suttnar J; Hirsch I; Vonka V; Department of Biochemistry, Institute of Hematology and Blood; Transfusion, Prague, Czech Republic.
The development of the Escherichia coli expression system, which was prepared by transferring the F episome from strain 71/18 to a highly to a transformable F- strain HB101, is described. These new HB101 (F+) cells, which produced high levels of lac repressor, were capable of taking up lactose and grew under strict s


Quantitative determination of CGP 53,437, a new HIV protease inhibitor, in plasma by high-performance liquid chromatography and fluorescence detection.
J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):155-61. Unique Identifier : AIDSLINE MED/95039765
Flesch G; Mann C; Boss E; Lang M; Degen PH; Dieterle W; Ciba-Geigy Ltd, Basle, Switzerland.
A specific and sensitive liquid chromatographic assay for CGP 53,437 (I), a potent HIV protease inhibitor, is described. The method is based on a deproteinization step, followed by a liquid-liquid extraction with diisopropyl ether. Then a deprotection step of the primary amine and derivatization using fluorescamine is


High-performance liquid chromatographic assay for 2'-deoxy-3'-thiacytidine in human serum.
J Chromatogr B Biomed Appl. 1994 Jul 1;657(1):227-32. Unique Identifier : AIDSLINE MED/95039775
Harker AJ; Evans GL; Hawley AE; Morris DM; Drug Metabolism Department, Glaxo Research and Development,; Greenford, Middlesex, UK.
A high-performance liquid chromatographic method for the determination of 2 -deoxy-3 -thiacytidine ( 3TC ), a novel dideoxy-nucleoside analogue, in human serum is described. 3TC was extracted from serum samples using Bond Elut Certify solid-phase extrac


High-performance liquid chromatographic measurement of the novel anti-HIV agent 7,8-dihydrocostatolide (NSC 661123).
J Chromatogr B Biomed Appl. 1994 Aug 5;658(1):129-33. Unique Identifier : AIDSLINE MED/95039817
Newman RA; Costa M; Cisneros A; University of Texas, M.D. Anderson Cancer Center, Department of; Clinical Investigation, Houston 77030.
An HPLC assay was used to determine levels of a promising anti-HIV agent 7,8-dihydrocostatolide (DC; NSC 661123) in human and murine plasma. The structurally related compound costatolide (C) was found to be a suitable internal standard. Drug was extracted from human or murine plasma using a solid-phase C18 cartridge.


Legislative wins for Maryland nurses.
Nurs Spectr (Wash D C). 1994 Oct 3;4(20):12. Unique Identifier : AIDSLINE MED/95039926
Zusy MJ
The Johns Hopkins master's program offers an HIV/AIDS specialty [news]
Nurs Spectr (Wash D C). 1994 Oct 17;4(21):4. Unique Identifier : AIDSLINE MED/95039934
Structure and transcriptional regulation of the GFAP gene.
Brain Pathol. 1994 Jul;4(3):245-57. Unique Identifier : AIDSLINE MED/95039981
Brenner M; Stroke Branch, National Institute of Neurological Disorders and; Stroke, National Institutes of Health, Bethesda, MD 20892.
Transcriptional regulation of the GFAP gene is intimately connected with astrocyte function: its initial activation marks the differentiation of astrocytes, and its up-regulation accompanies the reactive response to CNS injury. Studies of GFAP transcription should thus provide insights into multiple regulatory pathway


[Cryptococcal chorioretinitis and acquired immunodeficiency syndrome: apropos of a case]
Bull Soc Belge Ophtalmol. 1993;250:67-76. Unique Identifier : AIDSLINE MED/95040087
Bibas P; Van Vooren JP; Schakal A; Deworme A; Dargent JL; Zanen A; Service d'Ophthalmologie, Hopital Erasme, Universite Libre de; Bruxelles.
A patient with acquired immune deficiency and antecedents of pancreatitis presented with headaches, fever, dyspnea and bilateral decrease of vision. A diagnosis of disseminated cryptococcosis was made by lumbar puncture, alveolar washing and elevated cryptococcal antigen in blood, urine and stool. Bilateral chorioreti


Thalidomide in oral aphthous ulceration in patients with HIV infection [letter]
Palliat Med. 1994;8(3):255-6. Unique Identifier : AIDSLINE MED/95040101
Henriquet F; Roy MT; Repetto T; Fusco F
Polymerase chain reaction-assisted papillomavirus detection in cervicovaginal smears: stratification by clinical risk and cytology reports.
Virchows Arch. 1994;425(2):157-63. Unique Identifier : AIDSLINE MED/95040231
Kuhler-Obbarius C; Milde-Langosch K; Helling-Giese G; Salfelder A; Peimann C; Loning T; Department of Gynaecological Histopathology and Electron; Microscopy, University of Hamburg, Germany.
Seven hundred and twelve patients from cancer screening, pregnancy care, outpatient clinics for patients at risk for cervical dysplasia and human immunodeficiency virus (HIV) infection were tested simultaneously for cytological aberrations and human papillomavirus (HPV). Classification of these cases, and of all cytol


Changing use of intensive care for HIV-infected patients with Pneumocystis carinii pneumonia.
Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1305-10. Unique Identifier : AIDSLINE MED/95040290
Curtis JR; Greenberg DL; Hudson LD; Fisher LD; Krone MR; Collier AC; Robert Wood Johnson Clinical Scholars Program, Department of; Medicine, University of Washington, Seattle 98105.
Clinicians approach to acute respiratory failure from Pneumocystis carinii pneumonia (PCP) is hypothesized to have gone through three phases: aggressive management due to an absence of data on prognosis (1981-84), withholding of intensive care based on a few small studies showing high case fatality (1985-87), and an


Preventive therapy of tuberculosis with rifapentine in immunocompetent and nude mice.
Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1355-62. Unique Identifier : AIDSLINE MED/95040297
Chapuis L; Ji B; Truffot-Pernot C; O'Brien RJ; Raviglione MC; Grosset JH; Faculte de Medecine, Pitie-Salpetriere, Paris, France.
The effectiveness of intermittent administration of rifapentine (RPT), with or without isoniazid (INH), for preventive therapy of tuberculosis was evaluated in immunocompetent (normal) and nude mice. After infection with a small inoculum of Mycobacterium tuberculosis H37Rv, normal mice developed a chronic and nonfatal


Persistence of Pneumocystis carinii in patients with AIDS receiving chemoprophylaxis.
Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1456-9. Unique Identifier : AIDSLINE MED/95040313
Epstein LJ; Meyer RD; Antonson S; Strigle SM; Mohsenifar Z; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles,; CA 90049.
Pneumocystis carinii organisms have been shown to persist throughout therapy in the majority of patients with Pneumocystis carinii pneumonia (PCP). This study evaluated the relationship between persistence of organisms and recurrence of disease, and the effect of chemoprophylaxis on bronchoalveolar lavage specimens. S


Drug smoking, Pneumocystis carinii pneumonia, and immunosuppression increase risk of bacterial pneumonia in human immunodeficiency virus-seropositive injection drug users.
Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 1):1493-8. Unique Identifier : AIDSLINE MED/95040343
Caiaffa WT; Vlahov D; Graham NM; Astemborski J; Solomon L; Nelson KE; Munoz A; Department of Epidemiology, School of Hygiene and Public Health,; Johns Hopkins University, Baltimore, Maryland 21205.
To examine the risk factors for the first episode of bacterial pneumonia among human immunodeficiency virus (HIV)-seropositive injection drug users (IDUs), medical record review was performed on IDUs participating in a cohort study from January 1988 to June 30, 1992. HIV-seropositive IDUs with a first episode of bacte


A prospective evaluation of antituberculosis therapy in patients with human immunodeficiency virus infection.
Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 1):1499-502. Unique Identifier : AIDSLINE MED/95040344
Jones BE; Otaya M; Antoniskis D; Sian S; Wang F; Mercado A; Davidson PT; Barnes PF; Department of Medicine, University of Southern California School; of Medicine, Los Angeles 90033.
The purpose of this study was to determine the efficacy and toxicity of a standard antituberculosis regimen in patients with human immunodeficiency virus (HIV) infection. We prospectively evaluated 89 patients with tuberculosis and HIV infection at an urban medical center. Eighty-two patients received isoniazid, rifam


A rapid preadmission method for predicting inpatient course of disease for patients with HIV-related Pneumocystis carinii pneumonia.
Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 1):1503-7. Unique Identifier : AIDSLINE MED/95040345
Bennett CL; Weinstein RA; Shapiro MF; Kessler HA; Dickinson GM; Peterson B; Cohn SE; George WL; Gilman SC; Division of Health Services Research, Durham Veterans; Administration Hospital, North Carolina.
Pneumocystis carinii pneumonia (PCP) has been the most common reason for hospitalization and the most common cause of death for persons with HIV infection. Hospital mortality rates for PCP range from 10 to 60%. Studies that evaluate differences in hospital mortality rates must control for differences in patient severi


Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors [published erratum appears in Am J Respir Crit Care Med 1995 Mar;151(3 Pt 1):926]
Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 2):S176-82. Unique Identifier : AIDSLINE MED/95040397
Rose JR; Craik CS; Department of Pharmacology, University of California, San; Francisco.
The discovery of therapeutic agents has, in the past, started primarily with random screening efforts. These screens, although effective, are time-consuming and expensive. Attempts are now being made to design more efficient methods of screening that take into account available information about the three-dimensional


Homosexual erotomania and HIV infection.
Br J Psychiatry. 1994 Jun;164(6):842-6. Unique Identifier : AIDSLINE MED/95040776
Boast N; Coid J; Interim Secure Unit, Hackney Hospital, London.
A case of homosexual erotomania is described in a patient with AIDS-related complex. Direct involvement of the central nervous system was thought an unlikely cause, as specific stressors appeared to have precipitated a reactive psychosis. A psychodynamic understanding of these factors and their interaction with the pa


Risk of HIV for women who inject drugs [letter; comment]
Br J Psychiatry. 1994 Jun;164(6):849. Unique Identifier : AIDSLINE MED/95040780
Porter S; Elander J; Stephens S; Johns A; Edeh J
The european information centre on AIDS and youth.
Promot Educ. 1994 Sep;1(3):22-4. Unique Identifier : AIDSLINE MED/95040883
Reinders J; Department of School Health, Dutch Centre for Health Promotion; and Health Education, Utrecht, The Netherlands.
Analysis of lymphocyte subsets in a renal allograft recipient infected with human immunodeficiency virus.
Br J Urol. 1994 Sep;74(3):283-7. Unique Identifier : AIDSLINE MED/95041042
Hirano A; Yasukawa S; Ohkawa T; Takenaka T; Maeda J; Ooshima A; Department of Urology, Wakayama Medical College, Japan.
OBJECTIVE: To study the change in lymphocyte subsets of a renal allograft recipient who acquired human immunodeficiency virus (HIV) infection. PATIENT AND METHODS: A 53-year-old Japanese man who acquired HIV infection at the time of renal transplantation and died from opportunistic infection 3 years later was studied.


Autoimmune disease. Gadding around the beta cell.
Curr Biol. 1994 Feb 1;4(2):158-60. Unique Identifier : AIDSLINE MED/95041322
Cooke A; Department of Pathology, Cambridge University, UK.
Recent studies shed new light on the process by which T-cell tolerance to pancreatic beta-cell antigens breaks down, leading to the autoimmune disease insulin-dependent diabetes mellitus.


Immunodeficiency viruses. Not enough sans Nef.
Curr Biol. 1994 Jul 1;4(7):618-20. Unique Identifier : AIDSLINE MED/95041338
Littman DR; Howard Hughes Medical Institute, Department of Microbiology and; Immunology, University of California, San Francisco 94143-0414.
The nef genes of HIV and SIV are dispensable in vitro, but are essential for viral spread and disease progression in vivo. Nef-induced down-regulation of CD4, the viral receptor, may be the key to this requirement.


Varicella-zoster virus infection of the central nervous system in the acquired immune deficiency syndrome.
Brain. 1994 Oct;117 ( Pt 5):987-99. Unique Identifier : AIDSLINE MED/95041409
Gray F; Belec L; Lescs MC; Chretien F; Ciardi A; Hassine D; Flament-Saillour M; de Truchis P; Clair B; Scaravilli F; Departement de Pathologie (Neuropathologie), Hopital Henri; Mondor, Faculte de Medecine de Creteil, Universite Paris-Val; de Marne, France.
Productive varicella-zoster virus (VZV) infection of the central nervous system (CNS) was demonstrated in 11 acquired immune deficiency syndrome (AIDS) patients using immunocytochemistry and in situ hybridization. A characteristic zoster skin eruption was seen in only four cases. From our own series and 11 other cases


Community psychiatric nursing: drug-use and HIV-risk characteristics.
J Psychiatr Ment Health Nurs. 1994;1(1):49. Unique Identifier : AIDSLINE MED/95041641
Caan W
[AIDS. The trend of HIV/AIDS and the nurse's role in AIDS care]
Kanhohak Tamgu. 1993;2(2):118-37. Unique Identifier : AIDSLINE MED/95041709
Chang SB
Since the first case of AIDS was found among male homosexuals, the AIDS related problem has been in the male homosexual population, but the AIDS trend is changing from homosexuals to heterosexuals, with the majority of cases in the general population. Even though currently the reported HIV/AIDS cases in Korea are only


[AIDS. The etiologic agent for acquired immunodeficiency syndrome]
Kanhohak Tamgu. 1993;2(2):138-50. Unique Identifier : AIDSLINE MED/95041711
Lee WY
In 1981, an unusual case with immunodeficiency was reported and there after an epidemic fo the similar syndrome in population of homosexuals was recognized by Center for Diseases Control(CDC) U. S. A. Later the disease was characterized as an acquired immunodeficiency syndrome(AIDS). In 1983, virologists found the cau


[AIDS. Management of HIV infection in the hospital]
Kanhohak Tamgu. 1993;2(2):151-66. Unique Identifier : AIDSLINE MED/95041712
Park ES; Kim JM
Nosocomial infection is an infection associated with admission to health care facility. It is not known to be present or incubating at the time of admission. HIV(Human Immunodeficiency Virus) transmission spreads through parenteral exposure, sexual contact and perinatal exposure. HIV virus has been isolated from all b


Paget's disease: complications and controversies [editorial]
Calcif Tissue Int. 1994 Aug;55(2):75-8. Unique Identifier : AIDSLINE MED/95041837
Kaplan FS; Haddad JG; Singer FR
Infectious disease, infection control and the effect of a Florida cluster of cases of HIV infection [editorial]
J Can Dent Assoc. 1994 Oct;60(10):925-6. Unique Identifier : AIDSLINE MED/95041852
Epstein JB
The use of the clinical immunology laboratory.
Clin Rev Allergy. 1994 Summer;12(2):125-49. Unique Identifier : AIDSLINE MED/95042061
Yoshida SH; Veit BC; Mansfield LE; Gershwin ME; Division of Rheumatology, Allergy and Clinical Immunology,; University of California at Davis 95616.
Trends in cancer incidence in Connecticut, 1935-1991.
Cancer. 1994 Nov 15;74(10):2863-72. Unique Identifier : AIDSLINE MED/95042136
Polednak AP; Connecticut Tumor Registry, Connecticut Department of Public; Health and Addiction Services, Hartford 06106.
BACKGROUND. This study used data from the population-based Connecticut Tumor Registry, a unique resource for examining secular trends in cancer incidence rates since 1935. METHODS. Trends in average annual age-standardized incidence rates (ASRs) for invasive cancers in Connecticut residents were examined from 1935-193


Stabilization of the p53 gene product in two bovine leukemia virus infected cell lines.
Cancer Lett. 1994 Oct 28;86(1):33-40. Unique Identifier : AIDSLINE MED/95042250
Dees C; Godfrey VL; Foster JS; Schultz RD; Travis CC; Risk Analysis Section, Oak Ridge National Laboratory, TN; 37831-6109.
Fetal lamb kidney cells (FLK) and bat lung (BAT2CL6) cells that continuously produce bovine leukemia virus (BLV) were found to cause malignant tumors in nude mice. Uninfected bat lung cells (Tb 1 Lu) produced a small benign neoplasm. Pulse chase studies showed that the p53 gene product in BAT2CL6 cells was more stable


Squamous cell cervical lesions in women with and without AIDS. Biochemical risk factors, prevention, and policy.
Cancer Nurs. 1994 Aug;17(4):294-307. Unique Identifier : AIDSLINE MED/95042277
Lovejoy NC; Anastasi JK; Teachers College, Columbia University, New York, New York 10027.
Worldwide, squamous cell cervical cancer and intraepithelial lesions (SIL) are a major source of morbidity and mortality. Compared to women in general, women with human immunodeficiency syndromes (HIV) are at higher risk of developing SIL. With the HIV epidemic escalating among women, prevalence, morbidity, and mortal


Fungal infections associated with malignancies, treatments, and AIDS.
Cancer Nurs. 1994 Oct;17(5):411-7. Unique Identifier : AIDSLINE MED/95042290
Benedict S; Colagreco J; College of Nursing, Medical University of South Carolina,; Charleston 29425-2402.
Severe fungal infections have become increasingly common over the past 10 years, largely due to the greater number of immunocompromised patients, such as those infected with HIV and those undergoing immunosuppressive therapy for malignancies. Between 60% and 80% of people with AIDS, for example, develop at least one f


Vaginal epithelial DNA damage and expression of preneoplastic markers in mice during chronic dosing with tumorigenic levels of 3'-azido-2',3'-dideoxythymidine.
Cancer Res. 1994 Dec 1;54(23):6235-42. Unique Identifier : AIDSLINE MED/95042381
Olivero OA; Beland FA; Fullerton NF; Poirier MC; Laboratory of Cellular Carcinogenesis and Tumor Promotion,; National Cancer Institute, Bethesda, Maryland 20892.
3 -Azido-2 ,3 -dideoxythymidine ( AZT , Retrovir, zidovudine), a nucleoside analogue currently used in the therapy of acquired immunodeficiency syndrome, induces papillomas and carcinomas in vaginal epithelium of mice as a result of lifetime drug admini


Immunomodulation in patients receiving intravenous Bryostatin 1 in a phase I clinical study: comparison with effects of Bryostatin 1 on lymphocyte function in vitro.
Cancer Immunol Immunother. 1994 Oct;39(4):223-30. Unique Identifier : AIDSLINE MED/95042435
Scheid C; Prendiville J; Jayson G; Crowther D; Fox B; Pettit GR; Stern PL; Cancer Research Campaign Department of Immunology, Christie; Hospital, Paterson Institute for Cancer Research, Manchester, UK.
Bryostatin 1 is a protein kinase C activator that inhibits growth of tumour cells and activates lymphocytes in vitro, properties that have encouraged its use in phase 1 clinical studies as an anticancer agent. We investigated interleukin-2( IL-2 )-induced proliferation a


Specific interaction of 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid with human cellular CD4.
Cell Immunol. 1994 Nov;159(1):103-10. Unique Identifier : AIDSLINE MED/95042771
Schroeder K; Bowlin TL; Bridges G; Taylor D; Tyms AS; Cardin AD; Marion Merrell Dow Research Institute, Cincinnati, Ohio 45215.
We recently demonstrated that 4,4 -diisothiocyanatostilbene-2,2 -disulfonic acid (DIDS) prevented the infection of T cells by human immunodeficiency virus type-1 (Cardin et al., J. Biol. Chem. 266, 13355, 1991). In the present study we have used a panel of monoclonal antibodies (mabs) against a variety of human leukoc


Synthesis of immunoadjuvant conjugates with HIV-derived peptide inducing peptide-specific antibody.
Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1709-11. Unique Identifier : AIDSLINE MED/95042886
Maruyama Y; Kurimura M; Achiwa K; School of Pharmaceutical Sciences, University of Shizuoka, Japan.
[AIDS complicated with disseminated toxoplasmosis: a pathological study of 9 autopsy cases]
Chung-hua Ping Li Hsueh Tsa Chih. 1994;23(3):166-9. Unique Identifier : AIDSLINE MED/95042920
Liu DC; Lin CS; Seshan V; Department of Pathology, Bengbu Medical College, Anhui.
Nine autopsy cases of disseminated toxoplasmosis in New York are reported. Brain were involved in 9 cases, heart in 8, lung in 4, and pancreas, GI tract, thyroid, lymph nodes and urogenital organs were also involved. There were toxoplasma encephalitis in 9 cases, myocarditis in 4, pneumonia in 3 and pancreatitis in 2.


In vitro analysis of cell-mediated immunity: clinical relevance.
Clin Chem. 1994 Nov;40(11 Pt 2):2162-5. Unique Identifier : AIDSLINE MED/95043410
Shearer GM; Clerici M; Experimental Immunology Branch, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892.
Cellular immunity, a major component of the immune system, contributes to protection against infections and plays a role in the rejection of foreign allografts. T helper cells and the antigen-presenting cells with which they interact provide important functions for cellular immune responses by generating helper signal


In situ characterization of lymphocytic immunophenotypes and interleukin-2 receptors in cutaneous tuberculosis and leprosy--a comparative evaluation.
Clin Exp Dermatol. 1994 Jul;19(4):312-6. Unique Identifier : AIDSLINE MED/95043489
Sehgal VN; Gupta RP; Karmakar S; Logani KB; Jain S; Department of Dermatology and Venereology, University College of; Medical Sciences, New Delhi, India.
The granulomas of lupus vulgaris (LV) were characterized by preponderance of CD4+ lymphocytes and a raised CD4+/CD8+ ratio. In contrast, in scrofuloderma (SF) the CD8+ T-lymphocyte subpopulation predominated and the CD4+/CD8+ ratio was significantly decreased. A higher percentage of lymphocytes expressed interleukin-2


Chronic verrucous varicella-zoster infection in a patient with AIDS.
Clin Exp Dermatol. 1994 Jul;19(4):327-9. Unique Identifier : AIDSLINE MED/95043493
Vaughan Jones SA; McGibbon DH; Bradbeer CS; St John's Institute of Dermatology, St Thomas' Hospital, London,; UK.
The expression of herpes varicella zoster virus in patients already infected with the human immunodeficiency virus (HIV) provides the perfect illustration of an opportunist microbe at work. There is an increased incidence of herpes zoster which may be more severe, recurrent or disseminated. Likewise, varicella may be


Hairy leucoplakia and HIV-2--a case report and review of the literature.
Clin Exp Dermatol. 1994 Jul;19(4):335-40. Unique Identifier : AIDSLINE MED/95043496
Labandeira J; Peteiro C; Toribio J; Department of Dermatology, General Hospital of Galicia, Faculty; of Medicine, Santiago de Compostela, Spain.
Type 2 human immunodeficiency virus (HIV-2), originally confined to West Africa, has lately appeared with increasing frequency in Europe. Oral lesions affect a large proportion of patients with AIDS. Hairy leucoplakia (HL), a clinical expression of Epstein-Barr virus (EBV), is a lesion of the oral mucosa (usually the


Reiter's disease in a homosexual HIV-positive male.
Clin Exp Dermatol. 1994 Sep;19(5):430-3. Unique Identifier : AIDSLINE MED/95043528
Vaughan Jones SA; McGibbon DH; St John's Institute of Dermatology, St Thomas' Hospital, London,; U.K.
Pemphigus vegetans in an HIV-1-infected man [letter]
Clin Exp Dermatol. 1994 Sep;19(5):447. Unique Identifier : AIDSLINE MED/95043532
Mahe A; Flageul B; Prost C; Intrator L; Bobin P
HIV-1 recombinant gp160 vaccine given in accelerated dose schedules. NIAID AIDS Vaccine Clinical Trials Network.
Clin Exp Immunol. 1994 Nov;98(2):178-84. Unique Identifier : AIDSLINE MED/95043538
Gorse GJ; Schwartz DH; Graham BS; Matthews TJ; Stablein DM; Frey SE; Belshe RB; Clements ML; Wright PF; Eibl M; et al; Department of Internal Medicine, Saint Louis University School of; Medicine, MO.
The purpose of this randomized, double-blind study was to test the safety and immunogenicity of an HIV-1LAI recombinant gp160 (rgp160) vaccine in healthy, uninfected volunteers using accelerated dosing schedules. Thirty volunteers were randomly assigned to receive 50-micrograms doses of rgp160 in one of two immunizati


Analysis of lymphocyte cell death and apoptosis in HIV-2-infected patients.
Clin Exp Immunol. 1994 Nov;98(2):185-9. Unique Identifier : AIDSLINE MED/95043539
Jaleco AC; Covas MJ; Victorino RM; Servico de Medicina 2/Imunologia Clinica, Faculdade de; Medicina, Hospital Universitario de Santa Maria, Lisboa,; Portugal.
Recent evidence suggests that T cell apoptosis could be involved in the pathogenesis of HIV-1 infection. As the progression of HIV-2 associated disease appears to be slower than that of HIV-1, we investigated whether there were differences in the degree of T cell death and apoptosis in peripheral blood mononuclear cel


Interactions between murine AIDS (MAIDS) and toxoplasmosis in co-infected mice.
Clin Exp Immunol. 1994 Nov;98(2):190-5. Unique Identifier : AIDSLINE MED/95043540
Lacroix C; Levacher-Clergeot M; Chau F; Sumuyen MH; Sinet M; Pocidalo JJ; Derouin F; Institut National de la Sante et de la Recherche Medicale,; Unite 13, Paris, France.
We coinfected C57B1/6 mice with LP-BM5 murine leukaemia viruses, responsible for murine AIDS (MAIDS), and an avirulent strain of Toxoplasma gondii. Virus-infected mice were infected perorally on day 30 with 10 cysts of T. gondii, and T. gondii-infected mice were challenged with LP-BM5 on day 20, 30 or 60 after parasit


Characterization of the virulence of Mycobacterium avium complex (MAC) isolates in mice.
Clin Exp Immunol. 1994 Nov;98(2):210-6. Unique Identifier : AIDSLINE MED/95043543
Pedrosa J; Florido M; Kunze ZM; Castro AG; Portaels F; McFadden J; Silva MT; Appelberg R; Centro de Citologia Experimental, University of Porto, Portugal.
The virulence of different isolates of MAC was studied in naturally susceptible BALB/c mice. In preliminary experiments, MAC bacteria forming smooth transparent colonies on solid media (SmT variants) were found to be virulent for BALB/c mice, causing progressive infection; smooth opaque (SmOp) were generally avirulent


Encapsulation of Cryptococcus neoformans regulates fungicidal activity and the antigen presentation process in human alveolar macrophages.
Clin Exp Immunol. 1994 Nov;98(2):217-23. Unique Identifier : AIDSLINE MED/95043544
Vecchiarelli A; Pietrella D; Dottorini M; Monari C; Retini C; Todisco T; Bistoni F; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.
Our previous studies have shown that unstimulated alveolar macrophages (AM) play a predominant role as antigen-presenting cells in Cryptococcus neoformans infections, while the function as effector cells seems to be of minor relevance. The present study focuses on the role of encapsulation of C. neoformans on fungicid


Microglial cells qualify as the stimulators of unprimed CD4+ and CD8+ T lymphocytes in the central nervous system.
Clin Exp Immunol. 1994 Nov;98(2):313-8. Unique Identifier : AIDSLINE MED/95043559
Cash E; Rott O; INSERM U283, Cochin Hospital, Paris, France.
The potential of central nervous system (CNS)-derived cells for initiating T cell responses is not known. Using the capacity of unprimed T cells to respond to allogeneic determinants on antigen-presenting cells (APC), we assessed the ability of microglial cells to act as stimulators of primary T cell responses in vitr


Phenotypic heterogeneity of persistent expansions of CD4+ CD8+ T cells.
Clin Immunol Immunopathol. 1994 Dec;73(3):312-20. Unique Identifier : AIDSLINE MED/95043583
Tonutti E; Sala P; Feruglio C; Yin Z; Colombatti A; Istituto di Chimica Clinica, Ospedale S. Maria della; Misericordia, Udine, Italy.
A group of 18 individuals is described that manifest persistent (follow up between 4 and 57 months) expansions (ranging from 10 to 70%) of CD4+ CD8+ peripheral T cells. In nine individuals there was no apparent underlying disease whereas the remaining displayed a wide range of unrelated diseases. Analysis of the cell


[A family case of HAM and HTLV-I carrier including two sisters presenting with myositis]
Rinsho Shinkeigaku. 1994 Jun;34(6):563-8. Unique Identifier : AIDSLINE MED/95043742
Hokezu Y; Higuchi I; Yanai S; Nagai M; Nagamatsu K; Department of Neurology, Oita Prefectural Hospital.
We reported a family case of HAM and HTLV-I carrier including two sisters presenting with myositis. Both the 65-year-old elder sister and her 53-year-old younger sister initially noted lumbago and developed difficulty in walking several years later. Neurologic examination revealed muscle weakness of the proximal parts


[Hepatitis B virus antibody positive spastic paraparesis]
Rinsho Shinkeigaku. 1994 Jul;34(7):691-5. Unique Identifier : AIDSLINE MED/95043755
Hino H; Ayabe M; Honda J; Shoji H; Oizumi K; First Department of Internal Medicine, Kurume University School; of Medicine.
We present here thirteen patients (5 men and 8 women, aged 31 to 73, mean 55 years) with spastic paraparesis who showed clinical features similar to those of HTLV-1 associated myelopathy without HTLV-1 antibody, but with positive antibody to hepatitis B virus (HBV). All of these patients showed slowly progressive diff


The association between childhood sexual abuse and prevalence of HIV-related risk behaviors.
Clin Pediatr (Phila). 1994 Aug;33(8):498-502. Unique Identifier : AIDSLINE MED/95043827
Lodico MA; DiClemente RJ; Bayview-Hunter's Point Foundation, San Francisco, CA 94124.
AIDS knowledge and high risk behaviors in the chronic mentally ill.
Community Ment Health J. 1994 Aug;30(4):395-402. Unique Identifier : AIDSLINE MED/95044174
Katz RC; Watts C; Santman J; Psychology Dept., University of the Pacific, Stockton, CA 95211.
Chronic mentally ill adults are a high risk group for AIDS. In the present study, we used a questionnaire to assess AIDS knowledge, attitudes, and risk behaviors in 54 men and women who were clients at a drop in center for mentally ill adults. Most of the subjects were suffering from schizophrenia and about one-third


Training HIV specialists for community mental health.
Community Ment Health J. 1994 Aug;30(4):405-13; discussion 415-7. Unique Identifier : AIDSLINE MED/95044175
Knox MD; Friedrich MA; Gaies JS; Achenbach K; Department of Community Mental Health, University of South; Florida's Florida Mental Health Institute.
There is a critical need for trained HIV mental health specialists who possess the knowledge and attitudes necessary to meet the challenges of the HIV epidemic. A model for an intensive and experimental continuing education tutorial is briefly described, and evaluative data are presented. Upon completion of the three-


A qualitative process theory based model of the HIV-1 virus-cell interaction.
Comput Methods Programs Biomed. 1994 Jun;43(3-4):255-9. Unique Identifier : AIDSLINE MED/95044228
Ruggiero C; Giacomini M; Varnier OE; Gaglio S; Department of Communications, Computer and System Sciences,; University of Genova, Italy.
We present a qualitative model of the interaction between the HIV-1 virus and the human cell, based on qualitative process theory. This model takes into account a previous qualitative model of the cell growth. The model presented here can be regarded as a first step for setting up a comprehensive model of the HIV-1 vi


Medicine on wheels: an opportunity for outreach and housestaff education.
Conn Med. 1994 Sep;58(9):535-9. Unique Identifier : AIDSLINE MED/95044261
Barry M; Fleck E; Lentz S; Bell C; O'Connor P; Horwitz R; Department of Internal Medicine, Yale University School of; Medicine, New Haven.
Ambulatory-care teaching programs have been traditionally based in hospital settings. As many patients, in particular the homeless and underinsured, have never reached these settings, we describe a nontraditional outreach health-care program for medical residents. This multidisciplinary program places medical resident


Mice immunosuppressed by murine retrovirus infection (MAIDS) are susceptible to cytomegalovirus retinitis.
Curr Eye Res. 1994 Aug;13(8):587-95. Unique Identifier : AIDSLINE MED/95044373
Dix RD; Cray C; Cousins SW; Department of Ophthalmology, Bascom Palmer Eye Institute, Miami,; FL 33101.
Although various methods of immunosuppression have been used to enhance susceptibility of mice to murine cytomegalovirus (MCMV) retinitis, none reproduce the unique complexity of immune deficiency experienced by patients during the progression of AIDS. C57BL/6 mice are susceptible


Optic nerve morphometry following axonal degeneration from SAIDS in rhesus monkeys.
Curr Eye Res. 1994 Aug;13(8):619-23. Unique Identifier : AIDSLINE MED/95044377
Wurdeman AE; Rao NS; Tenhula WN; Foote T; Sadun AA; Doheny Eye Institute, Los Angeles, CA 90033.
In order to further study AIDS (acquired immunodeficiency syndrome) related neuropathologic findings, specifically progressive diffuse leuko-encephalopathy (PDL) and optic neuropathy, ten macaque monkeys (Macaca mulatta) were infected with simian immunodeficiency virus (SIV), observed for varying periods, and then sac


Mycobacterium marinum infection in a patient with the acquired immunodeficiency syndrome.
Cutis. 1994 Aug;54(2):103-5. Unique Identifier : AIDSLINE MED/95044399
Hanau LH; Leaf A; Soeiro R; Weiss LM; Pollack SS; Department of Medicine, Albert Einstein College of Medicine,; Bronx, New York 10461.
A variety of mycobacterial organisms may infect patients with acquired immunodeficiency syndrome. A patient with acquired immunodeficiency syndrome, lymphoma, and sporotrichoid Mycobacterium marinum is described. The patient responded completely to antimycobacterial therapy but relapsed when he discontinued his medica


Respiratory failure from severe Pneumocystis carinii pneumonia. Entering the third era [editorial]
Chest. 1994 Nov;106(5):1313-5. Unique Identifier : AIDSLINE MED/95044443
Wachter RM; Luce JM
Decreasing frequency but worsening mortality of acute respiratory failure secondary to AIDS-related Pneumocystis carinii pneumonia [see comments]
Chest. 1994 Nov;106(5):1456-9. Unique Identifier : AIDSLINE MED/95044472
Hawley PH; Ronco JJ; Guillemi SA; Quieffin J; Russell JA; Lawson LM; Schechter MT; Montaner JS; Canadian HIV Trials Network, St. Paul's Hospital/University of; British Columbia, Vancouver, Canada.
OBJECTIVE: To describe changes in incidence and outcome of acute respiratory failure (ARF) due to AIDS-related Pneumocystis carinii pneumonia (PCP) at a tertiary care center over the 4-year period starting April 1, 1987 with reference to previously reported data from the preceding 6 years. METHODS: All patients admitt


Clinical features of HIV-seropositive and HIV-seronegative patients with tuberculous pleural effusion in Dar es Salaam, Tanzania.
Chest. 1994 Nov;106(5):1471-5. Unique Identifier : AIDSLINE MED/95044476
Richter C; Perenboom R; Mtoni I; Kitinya J; Chande H; Swai AB; Kazema RR; Chuwa LM; Department of Medicine, Muhimbili Medical Centre, Dar es Salaam,; Tanzania.
In a prospective study, we investigated whether human immunodeficiency virus (HIV) infection alters the clinical presentation in patients with tuberculous pleuritis. One hundred twelve of 118 patients who presented with pleural effusion suffered from tuberculosis (TB); 65 patients (58%) were HIV seropositive. Evidence


Fatal mycobacterial infection in a 32-year-old man with AIDS.
Chest. 1994 Nov;106(5):1577-9. Unique Identifier : AIDSLINE MED/95044493
Whitson BD; George RB; Department of Medicine, Louisiana State University School of; Medicine, Shreveport.
Thoracoscopic findings in spontaneous pneumothorax in AIDS.
Chest. 1994 Nov;106(5):1582-6. Unique Identifier : AIDSLINE MED/95044495
Slabbynck H; Kovitz KL; Vialette JP; Kasseyet S; Astoul P; Boutin C; Department of Pneumology, Hopital de la Conception, Marseille,; France.
Six patients with the acquired immunodeficiency syndrome (AIDS) who suffered eight spontaneous pneumothoraces between January 1990 and January 1993 underwent videothoracoscopy. The predominant macroscopic findings, found in four patients on five occasions, were white-yellow nodules dispersed throughout the lung surfac


Unexplained CD4+ T-lymphocytopenia without evidence of HIV infection.
Chin Med J (Engl). 1994 Jul;107(7):545-7. Unique Identifier : AIDSLINE MED/95044583
Lee SS; Department of Health, Queen Elizabeth Hospital, Hong Kong.
The human immunodeficiency virus, HIV has long been known to be associated with CD4+ T-lymphocytopenia. In clinical practice, a low CD4 count usually implies an underlying HIV infection until proven otherwise. Non-HIV related CD4 depletion is a rare phenomenon, but has caused much public concern. A Chinese lady with u


[Minimally invasive surgery in persistent pneumothorax and pneumocystis carinii infection]
Chirurg. 1994 Aug;65(8):732-5. Unique Identifier : AIDSLINE MED/95044624
Stobernack A; Bach P; Kunze WP; Abteilung fur Thorax- und Gefasschirurgie, Lungenklinik Hemer.
The most frequent pulmological complication of AIDS is pneumocystis carinii pneumonia (PCP), which in 2% of cases will cause a spontaneous pneumothorax. Every AIDS patient who develops a pneumothorax is highly suspicious for a pneumocystis carinii pneumonia too. We describe the case of an AIDS patient who suffered fro


Toxoplasma pneumonia: cytologic diagnosis by bronchoalveolar lavage.
Diagn Cytopathol. 1994;11(1):52-5. Unique Identifier : AIDSLINE MED/95044749
Wheeler RR; Bardales RH; North PE; Vesole DH; Tricot G; Stanley MW; Department of Pathology, University of Arkansas for Medical; Sciences, Little Rock 72205.
Two cases of toxoplasma pneumonia in immunocompromised hosts are reported. The diagnoses were made by the identification of trophozoites in bronchoalveolar lavage material. The organisms were more readily identified in the air-dried Diff-Quik-stained smears. Cytologic findings and correlation with postmortem examinati


[The in vitro potentiation of LAK cell cytotoxicity in cancer and aids patients induced by F3--a fractionated extract of Astragalus membranaceus]
Chung Hua Chung Liu Tsa Chih. 1994 May;16(3):167-71. Unique Identifier : AIDSLINE MED/95044780
Chu DT; Lin JR; Wong W; Cancer Hospital, Chinese Academy of Medical Sciences, Beijing.
The in vitro induction of LAK cell activity was studied in cancer and AIDS patients. F3, an immuno-regulatory component of Astragalus membranaceus was shown capable of potentiating the LAK cell inducing activity of rIL-2. The killing activity against Hs294T melanoma cell line of LAK cells induced by 50 U/ml rIL-2 in t


Condom use rates for specific sexual behaviors among opioid abusers entering treatment.
Drug Alcohol Depend. 1994 Jun;35(3):231-8. Unique Identifier : AIDSLINE MED/95044852
King VL Jr; Brooner RK; Bigelow GE; Schmidt CW; Felch LJ; Gazaway PM; Department of Psychiatry and Behavioral Science, Johns Hopkins; University School of Medicine, Johns Hopkins Bayview Medical; Center, Baltimore, MD.
A structured interview was used to determine the details of high risk sexual behaviors, including number of sexual partners, frequency of condom use, and involvement in commercial sexual activity in 165 opioid abusers (mean age 34 years, 36% minority, 47% female) entering out-patient methadone substitution therapy. Th


[Accidental needle injuries of medical personnel]
Dtsch Med Wochenschr. 1994 Nov 11;119(45):1563-4. Unique Identifier : AIDSLINE MED/95044895
Ritzkowsky A; Institut fur Virologie, Universitat Furst-Puckler, Koln.
Typhoid fever: a review of its impact and diagnostic problems.
East Afr Med J. 1994 Mar;71(3):183-8. Unique Identifier : AIDSLINE MED/95045094
Petit PL; Wamola IA; Department of Microbiology, Academical Hospital Leiden, The; Netherlands.
A retrospective analysis was done on the diagnosis of typhoid fever based on clinical symptoms and available laboratory data over the last 16 years from rural areas of four African countries. This analysis concentrated on the reliability of diagnosis without cultures which cannot be performed in most rural hospitals d


Endoscopic appearance of a duodenal infection by Mycobacterium avium-intracellulare in AIDS.
Endoscopy. 1994 Jun;26(5):506. Unique Identifier : AIDSLINE MED/95045271
Bosch O; Porres JC; Martinez Quesada G; Oliva H; Gonzalez Campos C; Department of Gastroenterology, Fundacion Jimenez Diaz,; Universidad Autonoma de Madrid, Spain.
Realistic acceptance as a predictor of decreased survival time in gay men with AIDS.
Health Psychol. 1994 Jul;13(4):299-307. Unique Identifier : AIDSLINE MED/95045321
Reed GM; Kemeny ME; Taylor SE; Wang HY; Visscher BR; Department of Psychiatry and Biobehavioral Sciences, University; of California, Los Angeles 90024-1759.
Although theoretical accounts of adaptation in the terminally ill suggest that realistic acceptance of one s disease is adaptive, some investigations suggest that such responses are associated with increased mortality. This prospective psychobiological investigation involved 74 gay men with AIDS. Six scores reflecting


Psychosocial correlates and predictors of AIDS risk behaviors, abortion, and drug use among a community sample, of young adult women.
Health Psychol. 1994 Jul;13(4):308-18. Unique Identifier : AIDSLINE MED/95045322
Stein JA; Newcomb MD; Bentler PM; Department of Psychology, University of California, Los Angeles; 90024-1563.
Relations among latent constructs of Social Conformity, Sensation Seeking, Polydrug Use, Sexual Experience, Abortion, and Risky AIDS Behaviors were examined among a community sample of women (N = 438, mean age = 25.5 years) using confirmatory factor analysis (CFA) and predictive structural equation models (SEM). In th


EBNA-1, the major nuclear antigen of Epstein-Barr virus, resembles 'RGG' RNA binding proteins.
EMBO J. 1994 Oct 17;13(20):4840-7. Unique Identifier : AIDSLINE MED/95045375
Snudden DK; Hearing J; Smith PR; Grasser FA; Griffin BE; Department of Virology, Royal Postgraduate Medical School,; London, UK.
Nuclear antigen 1 (EBNA-1) is one of the key functions of the oncogenic DNA virus, Epstein-Barr virus (EBV), and is the only viral protein consistently expressed in EBV-associated malignancies. EBNA-1 binds in a site-specific manner to the viral DNA and is essential for viral replication, as well as for maintaining th


Rheumatoid arthritis as a primary manifestation of human immunodeficiency virus (HIV) infection.
Ethiop Med J. 1994 Jul;32(3):199-202. Unique Identifier : AIDSLINE MED/95045465
Addisu A; Gonder College of Medical Sciences.
Rheumatoid arthritis in a 23 year old soldier seen in Gonder, Ethiopia , in 1993 with a severe form of the disease is reported. The patient s serum was positive for human immunodeficiency virus (HIV) by both enzyme-linked immunoadsorbent assay (ELISA) and Western blot tests. Arthr


To test or not to test? [letter]
Ethiop Med J. 1994 Jul;32(3):203-4. Unique Identifier : AIDSLINE MED/95045466
Eshete H
Kex2p: a model for cellular endoprotease processing human immunodeficiency virus type 1 envelope glycoprotein precursor.
Eur J Biochem. 1994 Oct 15;225(2):565-72. Unique Identifier : AIDSLINE MED/95045505
Moulard M; Achstetter T; Kieny MP; Montagnier L; Bahraoui E; Laboratoire de Biochimie, CNRS URA 1455 - Ingenierie des; Proteines, Faculte de Medecine Secteur Nord, Marseille,; France.
The endoproteolytic cleavage of the envelope glycoprotein precursor (gp160) of the human immunodeficiency virus type 1 (HIV-1) by a cellular protease is required for full activation of the virus. In this study, processing of gp160 was analyzed in vitro using the Kex2p endoprotease from the yeast Saccharomyces cerevisi


Antibodies to antigen A60 in cerebrospinal fluid from patients with tuberculous meningitis.
Eur J Clin Microbiol Infect Dis. 1994 Jun;13(6):490-5. Unique Identifier : AIDSLINE MED/95045611
Lopez-Cortes LF; Nogales-Perez MC; Gomez-Mateos J; Jimenez-Hernandez D; Jimenez-Mejias E; Pachon-Diaz J; Infectious Diseases Unit, Hospital Universitario Valme, Seville,; Spain.
Cerebrospinal fluid (CSF) anti-mycobacterial antigen 60 (A60) IgM, IgG and IgA in patients affected by meningitis of different etiologies were assayed as a rapid diagnostic test in cases of tuberculous meningitis. A commercial EIA was used to test 127 CSF samples classified as follows: tuberculous meningitis (n = 27 C


Disseminated Nocardia farcinica infection in an AIDS patient.
Eur J Clin Microbiol Infect Dis. 1994 Jun;13(6):497-500. Unique Identifier : AIDSLINE MED/95045613
Miralles GD; Division of Infectious Diseases, Beth Israel Medical Center, New; York, New York 10003.
This report describes an AIDS patient presenting with disseminated Nocardia farcinica infection diagnosed by percutaneous kidney biopsy. The isolate was initially identified as Nocardia asteroides. Though Nocardia asteroides remains sensitive to most antimicrobial agents, Nocardia farcinica is resistant to gentamicin,


Successful treatment of Toxoplasma gondii myocarditis in an AIDS patient.
Eur J Clin Microbiol Infect Dis. 1994 Jun;13(6):500-4. Unique Identifier : AIDSLINE MED/95045614
Albrecht H; Stellbrink HJ; Fenske S; Schafer H; Greten H; Department of Internal Medicine, University Clinic Eppendorf,; Hamburg, Germany.
Central nervous system disease due to Toxoplasma gondii is a common cause of morbidity and mortality in patients with the acquired immunodeficiency syndrome. Cardiac toxoplasmosis, however, has been described in only a limited number of cases. In a 45-year-old patient with symptoms suggestive of myocarditis, Toxoplasm


Two cases of laryngeal leishmaniasis in patients infected with HIV.
Eur J Clin Microbiol Infect Dis. 1994 Jun;13(6):509-11. Unique Identifier : AIDSLINE MED/95045617
Gonzalez-Anglada MI; Pena JM; Barbado FJ; Gonzalez JJ; Redondo C; Galera C; Nistal M; Vazquez JJ; Department of Internal Medicine, Hospital La Paz, Faculty of; Medicine, Universidad Autonoma, Madrid, Spain.
A high incidence of visceral leishmaniasis has been documented in HIV-infected patients in endemic areas. In these patients, atypical locations and a chronic course of the disease are more frequent. Two AIDS patients with laryngeal leishmaniasis are reported. These cases are believed to be the first of this type docum


Treatment of testicular seminoma in patients with HIV infection. Report of two cases.
Eur Urol. 1994;26(2):184-6. Unique Identifier : AIDSLINE MED/95045825
Krain J; Dieckmann KP; Department of Urology, Free University of Berlin, Klinikum; Steglitz, FRG.
The problem of adequate management of testicular germ cell tumors in patients with AIDS is increasingly important, as reflected by the increasing number of reports on the unclear pathogenetic association of the two conditions. Two HIV-positive patients (32 and 39 years old) at CDC stages II and IIb with pure seminoma


Plasma lipids in HIV-infected patients: a prospective study in 95 patients.
Eur J Clin Invest. 1994 Jun;24(6):416-20. Unique Identifier : AIDSLINE MED/95045843
Constans J; Pellegrin JL; Peuchant E; Dumon MF; Pellegrin I; Sergeant C; Simonoff M; Brossard G; Barbeau P; Fleury H; et al; Service de Medecine Interne et Pathologie Vasculaire, Hopital; Saint-Andre, Bordeaux, France.
The present study aimed to determine plasma lipid levels in 95 HIV-infected patients divided into four groups according to the CD4 lymphocyte counts comparatively to a control group of 20 HIV-negative normolipidaemic subjects. A relationship between lipidic abnormalities and immune or nutritional status was also inves


Viral superantigen-induced hyporesponsiveness of T cells and polyclonal B cell activation in HIV-1 infection.
Eur J Immunol. 1994 Nov;24(11):2595-601. Unique Identifier : AIDSLINE MED/95045902
Scott-Algara D; Lafon M; Vuillier F; Pialoux G; Dauguet C; Dighiero G; Unite d'Immuno-hematologie et d'Immunopathologie, Hopital; Pasteur, Paris, France.
The mechanisms of CD4 depletion and hyporesponsiveness during human immunodeficiency virus (HIV) infection are still unknown. Given the ability of superantigens to stimulate a higher number of lymphocytes than conventional antigens, they may play a major role in this process. Recently, a novel superantigen, the rabies


Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity.
Eur J Immunol. 1994 Nov;24(11):2646-52. Unique Identifier : AIDSLINE MED/95045909
Jabado N; Le Deist F; Fisher A; Hivroz C; INSERM U 132, Hopital, Necker-Enfants Malades, Paris, France.
The membrane glycoprotein CD4 is required for optimal antigen-mediated activation of CD4+ T cells restricted by class II molecules of the major histocompatibility complex (MHC). CD4 cross-linking by anti-CD4 antibodies or binding by human immunodeficiency virus (HIV) gp120 has been shown to inhibit antigen-dependent a


CR1(CD35) and CR2(CD21) complement C3 receptors are expressed on normal human thymocytes and mediate infection of thymocytes with opsonized human immunodeficiency virus.
Eur J Immunol. 1994 Nov;24(11):2784-8. Unique Identifier : AIDSLINE MED/95045928
Delibrias CC; Mouhoub A; Fischer E; Kazatchkine MD; INSERM U28, Hopital Broussais, Paris, France.
The present study demonstrates that the C3b receptor CR1 (CD35) and the C3dg/Epstein-Barr virus receptor CR2 (CD21) are expressed by 25% and 70% of normal human thymocytes, respectively. The expression of CR2 extends to both CD1+ and CD1- cells in the thymus. Two subsets of CR2+ thymocytes were defined expressing low


The mixotope: a combinatorial peptide library as a T cell and B cell immunogen.
Eur J Immunol. 1994 Nov;24(11):2789-95. Unique Identifier : AIDSLINE MED/95045929
Estaquier J; Gras-Masse H; Boutillon C; Ameisen JC; Capron A; Tartar A; Auriault C; Unite mixte INSERM U167-CNRS 624, Lille, France.
We report a new approach in peptide vaccine strategy based on combinatorial synthesis. A library of 7.5 x 10(5) related peptides, termed mixotope, was derived from the sequence of the third hypervariable domain (V3 loop) of the human immunodeficiency virus (HIV) envelope protein. This preparation induced a strong immu


Suppression of the transformed phenotype in hybrids of human T-cell leukemia virus type I tax-transformed rat fibroblasts and normal human fibroblasts.
Exp Cell Res. 1994 Nov;215(1):68-74. Unique Identifier : AIDSLINE MED/95046061
Inoue H; Yamaoka S; Imamura M; Hatanaka M; Institute for Virus Research, Kyoto University, Japan.
We have isolated and characterized hybrid cell lines derived from Rat-2 cells transformed by the human T-cell leukemia virus type-I (HTLV-I) Tax protein fused with WI-38 normal human fibroblasts. These hybrid cells (designated as RTW cells) showed contact inhibition after growing to confluency, loss of anchorage-indep


[Seroprevalence rate of HIV in pregnant women in Bologna]
Epidemiol Prev. 1993 Sep;17:219-22. Unique Identifier : AIDSLINE MED/95046077
Marri E; Bianchi S; Podo O; Calabria MA; Milandri GL; Palareti A; Osservatorio Epidemiologico di Bologna.
The aim of the present study was to estimate the seroprevalence rate of HIV in pregnant women at the moment of labor in order to evaluate the need of a generalized HIV testing on all pregnant women. The research has been accomplished by Epidemiologic Observatory in Bologna in cooperation with the gynaecological divisi


Decrease of heat shock protein 27/28 with heat stress in HTLV-I-transformed cells.
Exp Mol Pathol. 1994 Jun;60(3):147-57. Unique Identifier : AIDSLINE MED/95046169
Sun D; Sauk JJ; Archibald DW; Department of Pathology, School of Dentistry, University of; Maryland, Baltimore 21201.
We have previously reported an increase of human T-lymphotropic leukemia/lymphoma virus type I (HTLV-I) replication after heat treatment of MT-2 cells, an HTLV-I-transformed human lymphoid cell line. In this study, we investigated the effect of heat stress on the expression of Hsp27/28 in MT-2 cells. In contrast with


Clinical and mycological evaluation of fluconazole in the secondary prophylaxis of esophageal candidiasis in AIDS patients. An open, multicenter study.
Eur J Epidemiol. 1994 Feb;10(1):17-22. Unique Identifier : AIDSLINE MED/95046179
Agresti MG; de Bernardis F; Mondello F; Bellocco R; Carosi GP; Caputo RM; Milazzo F; Chiodo F; Giannini V; Minoli L; et al; Istituto Superiore di Sanita, Laboratory of Virology, Rome,; Italy.
A prospective, multicenter, open study of fluconazole prophylaxis was performed in AIDS patients to evaluate the efficacy and toxicity of the drug in preventing relapses of esophageal candidiasis. To this aim, 99 AIDS patients who presented a first episode of clinically and microbiologically confirmed esophageal candi


Epidemiology and clinical manifestation of HIV infection in northern Zaire.
Eur J Epidemiol. 1994 Feb;10(1):95-8. Unique Identifier : AIDSLINE MED/95046195
Strecker W; Gurtler L; Schilling M; Binibangili M; Strecker K; Department of Traumatology, University of Ulm, Germany.
1275 patients were evaluated for HIV-1 + 2 seroprevalence and its association with clinical symptoms of HIV infection. Of 667 apparently healthy subjects, 8.2% had anti-HIV-1 antibodies. In 465 patients with clinical signs of AIDS, 39.4% were seropositive. 143 patients with miscellaneous symptoms had positive predicti


In vitro improvement of bone marrow-derived hematopoietic colony formation in HIV-positive patients by alpha-D-tocopherol and erythropoietin.
Eur J Haematol. 1994 Oct;53(4):201-6. Unique Identifier : AIDSLINE MED/95046199
Geissler RG; Ganser A; Ottmann OG; Gute P; Morawetz A; Guba P; Helm EB; Hoelzer D; University of Frankfurt/Main, Germany.
The majority of patients with progressive HIV infection develop a severe hematopoietic failure which is aggravated by the hematotoxic effect of azidothymidine ( AZT ) treatment. Since it was shown in a mouse model that alpha-D-tocopherol (vitamin E deri


Which is more important to high school students: preventing pregnancy or preventing AIDS? [see comments]
Fam Plann Perspect. 1994 Jul-Aug;26(4):154-9. Unique Identifier : AIDSLINE MED/95046212
Langer LM; Zimmerman RS; Katz JA; Florida International University, Miami.
A sample of about 2,900 high school students in greater Miami, Florida, was surveyed to determine their attitudes toward pregnancy prevention vs. AIDS prevention and how these attitudes affect condom use. Female, Hispanic and black respondents were the most likely to consider pregnancy and AIDS prevention to be equall


Nonsense mutations in the vpr gene of HIV-1 during in vitro virus passage and in HIV-1 carrier-derived peripheral blood mononuclear cells.
FEBS Lett. 1994 Oct 31;354(1):17-22. Unique Identifier : AIDSLINE MED/95046298
Nakaya T; Fujinaga K; Kishi M; Oka S; Kurata T; Jones IM; Ikuta K; Section of Serology, Hokkaido University, Sapporo, Japan.
Long-term, persistent infection by HIV-1 is a prerequisite for the development of AIDS. However, little is known of the determinants required for HIV-1 to cause persistence. We have reported previously that persistent infection of a T cell line by a cytopathogenic strain of HIV-1 became increasingly likely with in vit


Enhancing the recognition of tumour associated antigens.
Folia Biol (Praha). 1994;40(1-2):74-88. Unique Identifier : AIDSLINE MED/95046484
Restifo NP; Minev BR; Taggarse AS; McFarland BJ; Wang M; Irvine KR; Surgery Branch, Division of Cancer Treatment, National Cancer; Institute, National Institutes of Health, Bethesda, Maryland; 20892.
Activated CD8+ T cells (TCD8+) can directly recognize malignant cells because processed fragments of tumour associated antigens (TAA), 8-10 amino acids in length and complexed with MHC class I molecules, are displayed on tumour cell surfaces. Tumour cells have been genetically modified in a variety of ways in efforts


Risk identification for HIV infection in an inner London antenatal population.
Eur J Obstet Gynecol Reprod Biol. 1994 Jun 15;55(2):141-4. Unique Identifier : AIDSLINE MED/95046586
Hawken J; Chard T; Costeloe K; Jeffries D; Grant K; Hudson C; Department of Obstetrics, St. Bartholomew's Hospital, London, UK.
This study was carried out to ascertain whether routine antenatal history taking is an effective means of identifying risk factors for HIV infection. Information about risk obtained at routine booking was compared with answers to selected questions obtained at a research interview. The study was conducted at St. Barth


Safety and immunogenicity of recombinants based on the genetically-engineered vaccinia strain, NYVAC.
Dev Biol Stand. 1994;82:125-9. Unique Identifier : AIDSLINE MED/95046924
Tartaglia J; Cox WI; Pincus S; Paoletti E; Virogenetics Corporation, Rensselaer Technology Park, Troy, NY.
NYVAC-based recombinants expressing pertinent immunogens from equine influenza virus (EIV), pseudorabies virus (PRV), Japanese encephalitis virus (JEV) and human immunodeficiency virus (HIV) were used to evaluate the safety and immunogenicity of this vector. Administration of either NYVAC recombinants or parenteral vi


Expression of human immunodeficiency virus antigens in an attenuated Salmonella typhi vector vaccine.
Dev Biol Stand. 1994;82:159-62. Unique Identifier : AIDSLINE MED/95046928
Hone DM; Lewis GK; Beier M; Harris A; McDaniels T; Fouts TR; Department of Geographic Medicine, School of Medicine, University; of Maryland, Baltimore.
Human immunodeficiency virus is known to enter the host at parenteral and mucosal sites and consequently an effective vaccine should stimulate immunity at both routes of entry. One approach toward stimulating HIV-specific mucosal and systemic immunity is the use of candidate live oral Salmonella typhi vector vaccine,


Towards new mycobacterial vaccines.
Dev Biol Stand. 1994;82:171-8. Unique Identifier : AIDSLINE MED/95046930
Gicquel B; Unite de Genetique Mycobacterienne, Institut Pasteur, Paris,; France.
BCG, the Bacillus of Calmette and Guerin, has been used as a vector for the presentation of foreign antigens. The nef gene of HIV was cloned and expressed in BCG. A specific cellular immune response against Nef was observed following inoculation of mice. As a model system beta-galactosidase has also been expressed in


Adenovirus vectored vaccines.
Dev Biol Stand. 1994;82:71-7. Unique Identifier : AIDSLINE MED/95046945
Natuk RJ; Davis AR; Chanda PK; Lubeck MD; Chengalvala M; Murthy SC; Wade MS; Dheer SK; Bhat BM; Murthy KK; et al; Wyeth-Ayerst Research, Biotechnology & Microbiology Division,; Philadelphia, PA.
Human recombinant adenoviruses (Ad) have been employed to develop experimental vaccines against a number of infectious agents. Ad-vectored vaccines express recombinant proteins, including any post-translational modifications, into functioning replicas of the native proteins capable of eliciting neutralizing antibodies


Functions of glutathione and glutathione disulfide in immunology and immunopathology.
FASEB J. 1994 Nov;8(14):1131-8. Unique Identifier : AIDSLINE MED/95047083
Droge W; Schulze-Osthoff K; Mihm S; Galter D; Schenk H; Eck HP; Roth S; Gmunder H; Department of Immunochemistry, Deutsches Krebsforschungszentrum,; Heidelberg, Germany.
Even a moderate increase in the cellular cysteine supply elevates the intracellular glutathione (GSH) and glutathione disulfide (GSSG) levels and potentiates immunological functions of lymphocytes in vitro. At low GSSG levels, T cells cannot optimally activate the immunologically important transcription factor NF kapp


Resistance to amphotericin B associated with defective sterol delta 8-->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient.
FEMS Microbiol Lett. 1994 Sep 15;122(1-2):39-42. Unique Identifier : AIDSLINE MED/95047248
Kelly SL; Lamb DC; Taylor M; Corran AJ; Baldwin BC; Powderly WG; Krebs Institute for Biomolecular Research, Department of; Molecular Biology and Biotechnology, Sheffield University, UK.
Two Cryptococcus neoformans strains isolated from an AIDS patient were investigated, a pretreatment isolate (CN1) and a second isolate (CN3) following failure of fluconazole and amphotericin B treatment. No difference in fluconazole sensitivity, but relative resistance to amphotericin B was observed for CN3. The stero


An application of population genetic theory to synonymous gene sequence evolution in the human immunodeficiency virus (HIV).
Genet Res. 1994 Aug;64(1):1-9. Unique Identifier : AIDSLINE MED/95047303
Kelly JK; Department of Ecology and Evolution, University of Chicago, IL; 60637.
A population genetic model is developed and then applied to the synonymous gene sequence variation observed in samples of the Human Immunodeficiency Virus Type 1 (HIV-1). The samples, which were taken from several previous studies, contain sequences of the envelope glycoprotein gene (gp 120) of HIV-1. This analysis su


The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.
Genes Dev. 1994 Jul 1;8(13):1538-47. Unique Identifier : AIDSLINE MED/95047313
Meyer BE; Malim MH; Howard Hughes Medical Institute, University of Pennsylvania; School of Medicine, Philadelphia 19104-6148.
The HIV-1 Rev protein is a nuclear trans-activator essential for the transport of unspliced viral transcripts to the cytoplasm. In this paper we demonstrate that Rev, rather than being confined to the nucleus, is constantly shuttling between the nucleus and the cytoplasm. We also show that inactivation of Rev s leucin


An env-like protein encoded by a Drosophila retroelement: evidence that gypsy is an infectious retrovirus.
Genes Dev. 1994 Sep 1;8(17):2046-57. Unique Identifier : AIDSLINE MED/95047354
Song SU; Gerasimova T; Kurkulos M; Boeke JD; Corces VG; Department of Biology, Johns Hopkins University, Baltimore,; Maryland 21218.
The gypsy element of Drosophila differs from most LTR retrotransposons in containing a third open reading frame that resembles retroviral env genes. The protein encoded by ORF3 is glycosylated and processed, like all retroviral envelope proteins. The protein is expressed at high levels in fly strains in which gypsy el


Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I.
Gene. 1994 Oct 21;148(2):371-3. Unique Identifier : AIDSLINE GENBANK/D12902
Nyunoya H; Morita T; Sato T; Honma S; Tsujimoto A; Shimotohno K; Virology Division, National Cancer Center Research Institute,; Tokyo, Japan.
Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes.
Gene. 1994 Nov 4;149(1):33-9. Unique Identifier : AIDSLINE MED/95047468
Zhou C; Bahner IC; Larson GP; Zaia JA; Rossi JJ; Kohn EB; Childrens Hospital Los Angeles, Department of Pediatrics,; University of Southern California School of Medicine, Los Angeles; 90027.
Gene therapy for AIDS requires the identification of genes which effectively inhibit HIV-1 replication coupled to an efficient vector system for gene delivery and expression. Hammerhead ribozymes are RNA molecules capable of catalytic cleavage of complementary RNA molecules. Ribozymes targeted against two portions of


Rapid isolation of highly productive recombinant Chinese hamster ovary cell lines.
Gene. 1994 Nov 18;149(2):341-4. Unique Identifier : AIDSLINE MED/95047500
Miloux B; Lupker JH; Sanofi Recherche, Centre de Labege, France.
An expression system combining a unit for the expression of the gene of interest reinforced by the hepatitis B virus X transactivator and a selectable gene weakened by the insertion of an A+T-rich sequence derived from the 3 -untranslated region of the granulocyte-macrophage colony-stimulating factor mRNA is described


The adequacy of cytology and colposcopy in diagnosing cervical neoplasia in HIV-seropositive women [see comments]
Gynecol Oncol. 1994 Oct;55(1):133-7. Unique Identifier : AIDSLINE MED/95047753
Fink MJ; Fruchter RG; Maiman M; Kelly P; Sedlis A; Webber CA; Chen P; Department of Obstetrics and Gynecology, State University of New; York-Health Science Center at Brooklyn 11203.
The purpose of this study was to compare cytology and colposcopy as predictors of cervical intraepithelial neoplasia (CIN) in women infected with the human immunodeficiency virus (HIV). A cross-sectional analysis of cytology, colposcopy, and colposcopic biopsy results from 51 HIV-seropositive women attending an ambula


Cervical intraepithelial neoplasia in women infected with the human immunodeficiency virus: outcome after loop electrosurgical excision.
Gynecol Oncol. 1994 Nov;55(2):253-8. Unique Identifier : AIDSLINE MED/95047792
Wright TC Jr; Koulos J; Schnoll F; Swanbeck J; Ellerbrock TV; Chiasson MA; Richart RM; Department of Pathology, College of Physicians and Surgeons of; Columbia University, New York, New York 10032.
Our clinical experience with loop electrosurgical excision as therapy for cervical intraepithelial neoplasia (CIN) in women infected with human immunodeficiency virus is described. Information for this analysis was obtained from a retrospective chart review of all women with biopsy-confirmed CIN treated by loop electr


The ex vivo transfer of the anti-HIV nucleoside compound d4T in the human placenta.
Gynecol Obstet Invest. 1994;38(1):1-4. Unique Identifier : AIDSLINE MED/95047817
Bawdon RE; Kaul S; Sobhi S; Department of Obstetrics and Gynecology, University of Texas; Southwestern Medical Center, Dallas 75235-9032.
The purpose of this study was to determine the ex vivo maternal-fetal placental transfer of 2 ,3 -didehydro-3 -deoxythymidine ( d4T ) and to compare it to the perfusion characteristics of 3 -azido-2 ,3-dideoxythymidine (


Frequency and significance of drug resistance in vulvovaginal candidiasis.
Gynecol Obstet Invest. 1994;38(2):130-3. Unique Identifier : AIDSLINE MED/95047842
Spinillo A; Nicola S; Colonna L; Marangoni E; Cavanna C; Michelone G; Department of Obstetrics and Gynecology, University of Pavia,; Italy.
The rates of non-albicans species and susceptibility to the main antimycotic drugs were evaluated in a series of 472 cultures of vulvar or vaginal specimens positive for Candida species. Torulopsis glabrata was associated more frequently than C. albicans with recurrent vulvovaginal candidiasis (18/40 vs. 72/379; p = 0


Clinical significance of monocytosis and human monocytic colony-stimulating factor in patients with adult T-cell leukaemia/lymphoma.
Haematologia (Budap). 1994;26(1):1-9. Unique Identifier : AIDSLINE MED/95047870
Tokioka T; Shimamoto Y; Motoyoshi K; Yamaguchi M; Department of Internal Medicine, Saga Medical School, Japan.
We studied 79 patients with adult T-cell leukaemia/lymphoma (ATL) and 11 human T-lymphotropic virus-type I (HTLV-I-carriers to investigate the clinical significance of absolute monocyte counts in peripheral blood. Monocytosis was observed in 20% of ATL patients, but in none of the HTLV-I carriers. ATL patients with ab


Report on a 3-year follow-up zidovudine (AZT) treatment in a group of HIV-positive patients with congenital clotting disorders.
Haematologia (Budap). 1994;26(1):17-27. Unique Identifier : AIDSLINE MED/95047872
Sartori MT; Mares M; Zerbinati P; Stocco D; Girolami A; Institute of Medical Semeiotics, University of Padua Medical; School, Italy.
Eleven (50%) of 22 HIV-seropositive patients suffering from congenital coagulation defects and followed at the Hemophilia Center of Padua met the eligibility criteria for zidovudine ( AZT ) therapy. A 3-year clinical and laboratory follow up is describe


Product liability for defective blood.
Haematologia (Budap). 1994;26(1):49-53. Unique Identifier : AIDSLINE MED/95047876
Newdick C; Department of Law, University of Reading, England.
Responsibility in transfusion practice. Reflections after the French trials.
Haematologia (Budap). 1994;26(1):55-7. Unique Identifier : AIDSLINE MED/95047877
Soulier JP
[Drinking of tap water and shower in clinics is risky for immunologically compromised patients (news)]
Fortschr Med. 1994 Aug 20;112(22-23):10. Unique Identifier : AIDSLINE MED/95047994
Gurtler L
[Analysis of HAM rat disease developed in HTLV-I carrier rat as an animal model of HAM/TSP in human]
Hokkaido Igaku Zasshi. 1994 Jul;69(4):867-75. Unique Identifier : AIDSLINE MED/95048136
Seto K; Third Department of Internal Medicine, Hokkaido University School; of Medicine, Sapporo, Japan.
Human T cell leukemia virus type I (HTLV-I) can be transmitted into several inbred strains of rats. Adult rats inoculated with HTLV-I immortalized human T cell line MT-2 at 8-37 weeks of age become seropositive HTLV-I carrier rats. Seropositive HTLV-I carrier rats of WKAH strain developed myelopathy similar to HAM/TSP


bcl-2 proto-oncogene and Epstein-Barr virus latent membrane protein-1 expression in AIDS-related lymphoma.
Histopathology. 1994 Jul;25(1):77-82. Unique Identifier : AIDSLINE MED/95048222
Schlaifer D; Brousset P; Attal M; Massip P; Payen C; Marchou B; Huguet F; Muller C; Laurent G; Pris J; et al; Department of Haematology, Clinique Dieulafoy, Toulouse, France.
The expression of bcl-2 protein and Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) was investigated in 18 cases of lymphoma occurring in the acquired immunodeficiency syndrome (AIDS). EBV small RNAs were detectable in tumour cells in all cases by in situ hybridization with EBER oligonucleotides. LMP-1 expr


Gastrointestinal disease in the immunocompromised patient.
Hum Pathol. 1994 Nov;25(11):1123-40. Unique Identifier : AIDSLINE MED/95048256
Rotterdam H; Tsang P; College of Physicians and Surgeons of Columbia University, New; York, NY.
Gastrointestinal (GI) disease is frequent in all types of immunocompromised patients but occurs with greatest frequency in patients with acquired immunodeficiency syndrome (AIDS). Thus, much of this review deals with human immunodeficiency virus (HIV)-related GI diseases. Gastrointestinal diseases in other immunocompr


A case of neural cell adhesion molecule-positive peripheral T-cell lymphoma associated with human T-cell lymphotrophic virus type 1 showing an unusual involvement of the gastrointestinal tract during the course of the disease.
Hum Pathol. 1994 Nov;25(11):1251-3. Unique Identifier : AIDSLINE MED/95048272
Hayashi K; Nakamura S; Koshikawa T; Kitoh K; Koike K; Komatsu H; Kuroda M; Kasahara M; Ueda R; Suchi T; Department of Pathology and Clinical Laboratories, Aichi Cancer; Center Hospital, Nagoya, Japan.
We report a case of neural cell adhesion molecule (NCAM)-positive peripheral T-cell lymphoma (PTCL), pleomorphic, medium and large cell type according to the updated Kiel classification, which was associated with human T-cell lymphotrophic virus type 1 (HTLV-1). The patient showed an unusual involvement of the gastroi


Regional distribution and incidence of human papillomavirus infections among heterosexual men and women with multiple sexual partners: a prospective study.
Genitourin Med. 1994 Aug;70(4):240-6. Unique Identifier : AIDSLINE MED/95048307
Van Doornum GJ; Prins M; Juffermans LH; Hooykaas C; van den Hoek JA; Coutinho RA; Quint WG; Municipal Health Service of Amsterdam, Department of Public; Health, The Netherlands.
OBJECTIVE--To assess prevalence, incidence and potential risk factors of human papillomavirus (HPV) infection among heterosexual men and women with multiple partners and to identify niches of HPV-infection. DESIGN--A prospective study of heterosexual men and women with multiple partners attending an STD clinic as part


Targeted HIV seroprevalence among Vietnamese in southern California.
Genitourin Med. 1994 Aug;70(4):265-7. Unique Identifier : AIDSLINE MED/95048312
Gellert GA; Moore DF; Maxwell RM; Mai KK; Higgins KV; Health Sciences Education Center, Millwood, VA 22646.
OBJECTIVE--The prevalence of HIV among southern California Vietnamese is unknown. We collected seroprevalence data on targeted Vietnamese in Orange County, California who may be at risk for HIV infection. METHODS--The assumption of elevated risk was based on rates of infection reported among other U.S. groups. Vietnam


Clinical and microbiological characteristics of symptomatic vulvovaginal candidiasis in HIV-seropositive women.
Genitourin Med. 1994 Aug;70(4):268-72. Unique Identifier : AIDSLINE MED/95048313
Spinillo A; Michelone G; Cavanna C; Colonna L; Capuzzo E; Nicola S; Department of Obstetrics and Gynaecology, University of Pavia,; IRCCS Policlinico S Matteo, Pavia, Italy.
OBJECTIVES--To evaluate the clinical and microbiological characteristics of symptomatic vaginal candidiasis in Human Immunodeficiency Virus (HIV)-seropositive women attending a gynaecologic outpatient clinic for sexually transmitted diseases (STDs). DESIGN--Vaginal, rectal and oral specimens from cases and controls we


Declining rates of gonorrhoea and syphilis in Strasbourg, France: a 20-year study.
Genitourin Med. 1994 Aug;70(4):273-7. Unique Identifier : AIDSLINE MED/95048314
Cribier B; Asch PH; Tardieu JC; Clinique Dermatologique, Hopitaux Universitaires de Strasbourg,; France.
OBJECTIVE--To report the epidemiology of gonorrhoea and syphilis during the years 1973-1992 in the Strasbourg STD clinic and to discuss the data in the light of changes in STD rates in western countries. DESIGN--Retrospective analysis of gonorrhoea and syphilis cases recorded annually, total number of consultations, H


Survival of men and women with AIDS: a comparative study [letter]
Genitourin Med. 1994 Aug;70(4):290. Unique Identifier : AIDSLINE MED/95048317
Iatrakis GM; Shah PN; Smith JR; Kitchen VS; Barton SE
A new human endogenous DNA sequence homologous to HTLV-I pol.
Genomics. 1994 Jul 1;22(1):244-6. Unique Identifier : AIDSLINE GENBANK/L19438
Fujihara K; Du TL; Selkirk S; Ward P; Rickert M; Hohmann P; Bisaccia E; Greenberg SJ; Department of Neurology, Roswell Park Cancer Institute, Buffalo,; New York.
Remembering Michelle.
Imprint. 1994 Sep-Oct;41(4):72-3. Unique Identifier : AIDSLINE MED/95048430
Baker W
HIV and AIDS education--taking it to the streets.
Imprint. 1994 Nov-Dec;41(5):56-7, 59. Unique Identifier : AIDSLINE MED/95048437
Koyama K
[Wellcome starts model experiment: training for young HIV-physicians]
Immun Infekt. 1994 Apr;22(2):VIII. Unique Identifier : AIDSLINE MED/95048470
[Intravenous immunoglobulin substitution in patients with ARC and AIDS (WR 3-6)]
Immun Infekt. 1994 Apr;22(2):53-5. Unique Identifier : AIDSLINE MED/95048475
Kiehl M; Stoll R; Domschke W; Medizinische Kliniken A, Universitat Munster.
HIV-infected patients acquire a profound dysfunction in humoral and cellular immunity. This immunological impairment causes a markedly increased incidence of recurrent infections. While effective prophylaxis of Pneumocystis carinii pneumonia is available, infections with other microorganisms still cause a high rate of


The role of CD4+ and CD8+ cells in normal F1 hybrid host in the resistance to lethal graft-versus-host disease induction by transfer of parent spleen cells.
Immunol Lett. 1994 Jun;40(3):207-10. Unique Identifier : AIDSLINE MED/95048510
Kitajima T; Iwashiro M; Kuribayashi K; Imamura S; Department of Dermatology, Faculty of Medicine, Kyoto University,; Japan.
Transfer of a certain number of C57BL/6 (B6) spleen cells into (BALB/cxB6)F1 (CB6F1) nu/nu mice, which are deficient in T cells, causes lethal graft-versus-host disease (GVHD) in the recipients. However, when normal CB6F1 mice are used as recipients, lethal GVHD does not occur. Using this lethal GVHD system, we invest


Comparative study of antibodies that are associated with disease progression in HIV disease.
Immunol Lett. 1994 Jun;41(1):33-6. Unique Identifier : AIDSLINE MED/95048527
Toth FD; Susal C; Ujhelyi E; Banhegyi D; Kiss J; Daniel V; Nagy I; Opelz G; Fust G; Institute of Microbiology, University Medical School, Debrecen,; Hungary.
Two types of antibodies which previously were found to be inversely associated with CD4+ cell counts and which may contribute to the progression of HIV disease were measured in parallel in 55 serum samples of 7 longitudinally tested HIV-infected patients (4 homosexual men, 3 haemophilic men) and in 15 serum samples fr


Flow cytometry in clinical pathology: theory and practice of looking beyond morphology.
Indian J Pathol Microbiol. 1994 Apr;37(2):221-33. Unique Identifier : AIDSLINE MED/95048627
Pandey J; Talib VH; Department of Laboratory Medicine, Safdarjung Hospital, New; Delhi.
Depletion of interleukin-4 in BALB/c mice with established Leishmania major infections increases the efficacy of antimony therapy and promotes Th1-like responses.
Infect Immun. 1994 Dec;62(12):5498-504. Unique Identifier : AIDSLINE MED/95048786
Nabors GS; Farrell JP; Department of Pathobiology, University of Pennsylvania School of; Veterinary Medicine, Philadelphia 19104.
Whereas most inbred mouse strains mount a protective Th1 helper T-cell response following infection with Leishmania major, an ineffective Th2 response develops in BALB/c mice, leading to the development of disseminated, ultimately fatal disease. Interleukin-4 (IL-4) production is required for the initiation of the Th2


CD4+ and CD8+ T-cell-dependent and -independent host defense mechanisms can operate to control and resolve primary and secondary Francisella tularensis LVS infection in mice.
Infect Immun. 1994 Dec;62(12):5603-7. Unique Identifier : AIDSLINE MED/95048800
Conlan JW; Sjostedt A; North RJ; Trudeau Institute, Inc., Saranac Lake, New York 12983.
Immunity to experimental infection with the facultative intracellular bacterium Francisella tularensis is generally considered an example of T-cell-mediated, macrophage-expressed immunity. However, the results of the present study indicate that T-cell-independent mechanisms are also important in anti-Francisella defen


Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls.
Infect Immun. 1994 Dec;62(12):5673-8. Unique Identifier : AIDSLINE MED/95048811
Sanchez FO; Rodriguez JI; Agudelo G; Garcia LF; Laboratorio Central de Investigaciones, Facultad de Medicina,; Universidad de Antioquia, Medellin, Colombia.
The aim of the present study was to determine the profile of immune responsiveness that differentiates patients with tuberculosis (TB) from healthy tuberculin-positive controls. Forty-five patients with pulmonary TB and 16 healthy tuberculin-positive controls, all human immunodeficiency virus negative, were studied. P


Adult T-cell leukemia/lymphoma: a working point-score classification for epidemiological studies.
Int J Cancer. 1994 Nov 15;59(4):491-3. Unique Identifier : AIDSLINE MED/95048879
Levine PH; Cleghorn F; Manns A; Jaffe ES; Navarro-Roman L; Blattner WA; Hanchard B; De Oliveira MS; Matutes E; Catovsky D; et al; National Cancer Institute, National Institutes of Health,; Bethesda, MD 20892.
Adult T-cell leukemia/lymphoma (ATL) is a malignancy that occurs most frequently in south-western Japan and the Caribbean basin. The primary etiologic agent for this disease, human T-lymphotropic virus type I (HTLV-I), is endemic in these areas. Only a small percentage of individual


Acculturation, sexual behavior, and alcohol use among Latinas.
Int J Addict. 1994 Jul;29(9):1101-14. Unique Identifier : AIDSLINE MED/95048974
Marin BV; Flores E; Center for AIDS Prevention Studies, University of California, San; Francisco 94105.
We explored the relationship of alcohol use to unsafe sex in Latinas. Telephone interviews were conducted with 523 currently sexually active Latinas aged 18-49 years. Only 7.5% of these women used alcohol half of the time or more prior to sex. Regular alcohol users had more sexual partners, but also had more experienc


The role of cultural and gender values in alcohol use patterns among Chicana/Latina high school and university students: implications for AIDS prevention.
Int J Addict. 1994 Jul;29(9):1149-71. Unique Identifier : AIDSLINE MED/95048977
Flores-Ortiz YG; Chicano Studies Program, University of California, Davis.
This paper presents preliminary findings of two studies conducted with Chicana/Latina secondary and university students. Ninety-four women were surveyed concerning alcohol and drug use, behavioral efficacy, knowledge of HIV infection, and sexual practices. In addition, two focus groups were conducted in the high schoo


Substance use patterns of Latinas: commentary.
Int J Addict. 1994 Jul;29(9):1189-99. Unique Identifier : AIDSLINE MED/95048979
Perez-Arce P; Substance Abuse Services, Ward 93, UCSF San Francisco General; Hospital 94110.
Six papers were presented in the course of a 2-day symposium on the topic of Latinas and Substance Use. The individuals invited to present included established as well as evolving female investigators within the fields of indigenous peoples psychology, sociology, and ethnography. Methodology used in the studies range


Seborrheic dermatitis as a revealing feature of HIV infection in Bamako, Mali [letter]
Int J Dermatol. 1994 Aug;33(8):601-2. Unique Identifier : AIDSLINE MED/95049031
Mahe A; Boulais C; Blanc L; Keita S; Bobin P
Behavioural risk factors and HIV infection of injection drug users at detoxification clinics in Puerto Rico.
Int J Epidemiol. 1994 Jun;23(3):595-601. Unique Identifier : AIDSLINE MED/95049056
Robles RR; Colon HM; Diaz N; Cancel LI; MacGowan R; Cole GE; Allen DM; Research Institute, Puerto Rico Department of Anti Addiction; Services, Rio Piedras 00928-1414.
BACKGROUND. The ethnic and geographical variations of AIDS prevalence among injection drug users (IDU) have highlighted the need to understand the role of the relevant risk factors in specific subpopulations of IDU. In this study we examine the factors related to seropositivity among IDU entering drug detoxification f


Sharing of injection equipment among 3755 intravenous drug users in Valencia, Spain, 1987-1992.
Int J Epidemiol. 1994 Jun;23(3):602-7. Unique Identifier : AIDSLINE MED/95049057
Hernandez-Aguado I; Ruiz I; Bolumar F; Perez-Hoyos S; Fernandez-Garcia E; Santos C; Torrella A; Garcia de la Hera M; Belda J; Avino MJ; Institut Valencia d'Estudis en Salut Publica (IVESP), Valencia,; Spain.
BACKGROUND. In order to identify, in a sample of heroin intravenous drug users (IVDU), those factors associated with the predominant risk behaviour related to the transmission of HIV-1 infection--sharing of injection equipment--a cross-sectional survey was carried out in Valencia, Spain


Screening for psychiatric morbidity in a medical outpatient clinic for HIV infection: the need for a psychiatric presence.
Int J Psychiatry Med. 1994;24(2):103-13. Unique Identifier : AIDSLINE MED/95049087
Lyketsos CG; Hanson A; Fishman M; McHugh PR; Treisman GJ; Johns Hopkins University School of Medicine, Baltimore, Maryland.
OBJECTIVE: To ascertain the prevalence and type of psychiatric morbidity present in HIV infected patients presenting for the first time to a specialty HIV medical clinic. Also, to develop a way of screening for psychiatric cases in this setting using established self-report questionnaires. METHOD: Fifty patients who p


[Social marketing applied to condom promotion: a proposal for intervention in groups at risk for sexually transmitted diseases]
Gac Sanit. 1994 Jul-Aug;8(43):169-79. Unique Identifier : AIDSLINE MED/95049127
Garcia Espana F; March Cerda JC; Gomez Villegas I; Escuela de Salud Publica, Granada.
Sexually transmitted diseases (STDs) are an important worldwide health problem. Their association with AIDS an other insidious viral processes have brought them to the foreground of sanitary authorities and general population concern. Often, health services have to struggle with reinfections, which concentrate in pock


Release hallucinations and tiapride.
Ital J Neurol Sci. 1994 May;15(4):183-7. Unique Identifier : AIDSLINE MED/95049360
Badino R; Trucco M; Caja A; Del Conte I; Guida C; Ivaldi M; Divisione di Neurologia, Ospedale Santa Corona, Pietra Ligure,; Savona.
The authors describe seven patients in whom the administration of tiapride led to the disappearance of visual hallucinatory manifestations with the characteristics of release hallucinations, the results being maintained throughout the period of treatment. The authors also discuss the mechanism and presumed site of act


[HIV-associated dermatoses and their prevalence in 456 HIV-infected patients. Relation to immune status and its importance as a diagnostic marker]
Hautarzt. 1994 Sep;45(9):623-9. Unique Identifier : AIDSLINE MED/95049461
Garbe C; Husak R; Orfanos CE; Universitats-Hautklinik und Poliklinik, Klinikum Steglitz,; Freien Universitat Berlin.
Some 456 patients with HIV-associated skin disorders were documented in the HIV follow-up clinics at the Department of Dermatology, University Medical Center Steglitz, Berlin, during the years 1982-1992. Males comprised 91% of the patients. The most important risk groups for HIV infection were homosexual and bisexual


Universal precautions: an update.
Heart Lung. 1994 Jul-Aug;23(4):352-8. Unique Identifier : AIDSLINE MED/95049562
Gershon RR; Karkashian C; Felknor S; School of Hygiene and Public Health, Johns Hopkins University,; Baltimore, MD 21205.
Universal precautions, the set of work practice recommendations designed to help minimize occupational exposure to bloodborne pathogens, have been shown to be effective. However, lack of compliance with these recommendations has been well documented, both before and after the enactment of the OSHA Bloodborne Pathogens


Ethical dilemmas encountered by home care nurses: caring for patients with acquired immune deficiency syndrome [published erratum appears in Home Healthc Nurse 1994 Nov-Dec;12(6):8]
Home Healthc Nurse. 1994 Sep-Oct;12(5):12-7; quiz 65-6. Unique Identifier : AIDSLINE MED/95049578
Chubon SJ
The results of two ethnographic studies of home care nurses work experiences showed that nurses caring for patients with acquired immune deficiency syndrome encounter a variety of ethical dilemmas. Examples of patients and nurses dilemmas are described. Suggestions are offered for helping nurses recognize these com


Quantitation of soluble HLA class I heterodimers and beta 2-microglobulin in patients with active pulmonary tuberculosis.
Hum Immunol. 1994 Jul;40(3):179-82. Unique Identifier : AIDSLINE MED/95049687
Inostroza J; Munoz P; Espinoza R; Millaqueo L; Diaz P; Leiva L; Sorensen R; Immunology Laboratory, Hospital de Temuco, Chile.
Beta 2m serum levels have been shown to be increased in patients with tuberculosis and HIV infection. We determined the stability of beta 2m and of sHLA-I dimers in serum, and then determined the levels of both molecules in 60 non-HIV-infected patients with active pulmonary tuberculosis and in 55 adult controls. The l


Should healthcare reform be 'color-blind'? Addressing the barriers to improving minority health.
J Am Osteopath Assoc. 1994 Aug;94(8):664-71. Unique Identifier : AIDSLINE MED/95049702
Ross-Lee B; Kiss LE; Weiser MA; Ohio University College of Osteopathic Medicine, Athens; 45701-2979.
The scandalous disparity between the health indicators for minority and nonminority and poor and nonpoor populations is of such long standing that it has lost th power to shock. The authors review the landmark studies of the past year which document discrimination in the healthcare system. They reiterate the most comp


Detection of HTLV-II-seropositive blood donors in South Vietnam but not in North Vietnam.
Jpn J Cancer Res. 1994 Sep;85(9):875-8. Unique Identifier : AIDSLINE MED/95049860
Yamamoto S; Nakata S; Nakasone T; Chosa T; Song P; Duc DD; Hien B; Quang NX; Trinh TN; Ono T; et al; Laboratory of Immunology, National Institute of Health, Tokyo.
Approximately 1% (4/500) of blood donors exhibited seropositivity for HTLV-II in South Vietnam , but none (0/500) did in North Vietnam. Further, all individuals seropositive for HTLV-II were intravenous drug abusers who were seronegative for HIV-1 and HTLV-I. These findings suggest


Expression of tumor-associated glycoantigen, sialyl Lewis(a), in human head and neck squamous cell carcinoma and its application to tumor immunotherapy.
Jpn J Cancer Res. 1994 Sep;85(9):887-91. Unique Identifier : AIDSLINE MED/95049863
Makino K; Ogata T; Miyake H; Habu S; Nishimura T; Department of Otorhinolaryngology, Tokai University School of; Medicine, Isehara.
The glycoantigen sialyl Lewis(a) (sLe(a)) is widely expressed on a variety of gastrointestinal tumor cells. Here, we immunohistochemically demonstrated the expression of sLe(a) antigen in 54% (7 out of 13) of human head and neck squamous cell carcinoma (H-NSCC) samples. Frequent expression of sLe(a antigen was also de


Chloropeptins I and II, novel inhibitors against gp120-CD4 binding from Streptomyces sp. [letter]
J Antibiot (Tokyo). 1994 Oct;47(10):1173-4. Unique Identifier : AIDSLINE MED/95049920
Matsuzaki K; Ikeda H; Ogino T; Matsumoto A; Woodruff HB; Tanaka H; Omura S
Drug intolerance in HIV disease.
J Antimicrob Chemother. 1994 Jul;34(1):1-5. Unique Identifier : AIDSLINE MED/95049954
van der Ven AJ; Koopmans PP; Vree TB; van der Meer JW; Department of General Internal Medicine, Academic Hospital; Nijmegen, The Netherlands.
Bicycle exercise enhances plasma IL-6 but does not change IL-1 alpha, IL-1 beta, IL-6, or TNF-alpha pre-mRNA in BMNC.
J Appl Physiol. 1994 Jul;77(1):93-7. Unique Identifier : AIDSLINE MED/95050050
Ullum H; Haahr PM; Diamant M; Palmo J; Halkjaer-Kristensen J; Pedersen BK; Copenhagen Muscle Research Center, Department of Infectious; Diseases, Rigshospitalet, Denmark.
The present study investigated the effect of concentric exercise on cytokine plasma levels and cytokine pre-mRNA in blood mononuclear cells (BMNCs). Healthy young moderately trained men performed ergometer bicycle exercise for 1 h at 75% of maximal oxygen uptake. The levels of plasma interleukin (IL)-6 increased signi


Applications of in situ hybridization in the study of hematologic malignancies.
Hematol Oncol Clin North Am. 1994 Aug;8(4):771-84. Unique Identifier : AIDSLINE MED/95050070
Uner AH; Hutchison RE; Davey FR; Department of Pathology, State University of New York Health; Science Center, Syracuse, New York.
In situ hybridization is a molecular technique that can be useful in the study of hematologic malignancies. Thus far, the most extensive uses have been in the detection of viral sequences and in the detection of chromosomal alterations. Other applications such as the identification of various cellular gene products ar


Effects of sertraline on mood and immune status in patients with major depression and HIV illness: an open trial.
J Clin Psychiatry. 1994 Oct;55(10):433-9. Unique Identifier : AIDSLINE MED/95050334
Rabkin JG; Wagner G; Rabkin R; New York State Psychiatric Institute, NY 10032.
BACKGROUND: To date, the efficacy of sertraline in treating depression in the context of human immunodeficiency virus (HIV) has not been investigated, despite the agent s advantageous side effect profile, low toxicity with overdose, and lack of adverse effect on the cardiovascular system. This 8-week open trial addres


Intracellular membrane traffic of human immunodeficiency virus type 1 envelope glycoproteins: vpu liberates Golgi-targeted gp160 from CD4-dependent retention in the endoplasmic reticulum.
J Biochem (Tokyo). 1994 May;115(5):1010-20. Unique Identifier : AIDSLINE MED/95050404
Kimura T; Nishikawa M; Ohyama A; Department of Microbiology, Kansai Medical University, Osaka.
The membrane traffic of human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins has been investigated in COS-1 cells transiently expressing the HIV-1 env, vpu, and rev genes. Analysis of oligosaccharide processing revealed that the majority of gp160 remained fully endo-H sensitive throughout a 21-h chase pe


Interaction with the Rev response element along an extended stem I duplex structure is required to complete human immunodeficiency virus type 1 rev-mediated trans-activation in vivo.
J Biochem (Tokyo). 1994 May;115(5):945-52. Unique Identifier : AIDSLINE MED/95050430
Kimura T; Ohyama A; Department of Microbiology, Kansai Medical University, Osaka.
Expression of structural proteins of human immunodeficiency virus type 1 requires the direct interaction of the viral Rev trans-activator with its cis-acting RNA target sequence, the Rev response element (RRE). The originally defined 234-residue RRE, however, failed to show the full HIV-1 regulator of virion expressio


Mutational analysis of the bipartite dimer linkage structure of human immunodeficiency virus type 1 genomic RNA.
J Biol Chem. 1994 Nov 4;269(44):27486-93. Unique Identifier : AIDSLINE MED/95050492
Paillart JC; Marquet R; Skripkin E; Ehresmann B; Ehresmann C; Unite Propre de Recherches No. 9002 du Centre National de la; Recherche Scientifique, Institut de Biologie Moleculaire et; Cellulaire, Strasbourg, France.
The genome of all retroviruses consists in two homologous RNA molecules associated near their 5 end in a region called the dimer linkage structure. Dimerization of genomic RNA is thought to be important for several functions of the retroviral cycle such as encapsidation, reverse transcription, and translation. In hum


Vascular smooth muscle cells express a constitutive NF-kappa B-like activity.
J Biol Chem. 1994 Nov 18;269(46):28913-8. Unique Identifier : AIDSLINE MED/95050706
Lawrence R; Chang LJ; Siebenlist U; Bressler P; Sonenshein GE; Department of Biochemistry, Boston University Medical School,; Massachusetts 02118.
The NF-kappa B/Rel family of transcription factors is commonly expressed in non-hematopoietic cells in an inactive form within the cytoplasm, complexed with an inhibitor I kappa B protein. Thus, it was surprising that NF-kappa B element-driven heterologous promoter-reporter gene constructs were active upon transient t


Biophysical and enzymatic properties of the catalytic domain of HIV-1 integrase.
J Biol Chem. 1994 Nov 18;269(46):29279-87. Unique Identifier : AIDSLINE MED/95050754
Hickman AB; Palmer I; Engelman A; Craigie R; Wingfield P; Laboratory of Molecular Biology, NIDDK, National Institutes of; Health, Bethesda, Maryland 20892.
A deletion derivative of the integrase protein from human immunodeficiency virus type-1 (HIV-1) consisting of the central core domain (amino acids 50-212) has been characterized biophysically and biochemically. This deletion mutant is of particular interest for structural studies as it can carry out the disintegration


HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte.
J Cell Biol. 1994 Nov;127(4):903-14. Unique Identifier : AIDSLINE MED/95050972
Baccetti B; Benedetto A; Burrini AG; Collodel G; Ceccarini EC; Crisa N; Di Caro A; Estenoz M; Garbuglia AR; Massacesi A; et al; Institute of General Biology, Consiglio Nazionale delle Ricerche,; Siena, Italy.
By immunocytochemistry and in situ hybridization at the electron microscopy level, and by the PCR technique, we have shown that HIV-1 binds and enters normal sperm; that viral particles, their antigens, and nucleic acid are present in sperm from HIV-1 infected men; and that such sperm can transfer HIV-1 like particles


Human monoclonal antibodies: recent achievements.
Hosp Pract (Off Ed). 1994 Nov 15;29(11):111, 114-6, 119 passim. Unique Identifier : AIDSLINE MED/95051158
Burton DR; Barbas CF 3rd; Department of Immunology, Scripps Research Institute, La Jolla,; Calif.
The latest developments include an anti-HIV antibody that has 1,000 times the affinity of natural antibody and that neutralizes primary clinical isolates, and an anti-RSV antibody that reduces viral titers in mice by 12,000-fold within 24 hours.


Acute nonspecific illness in an AIDS patients with dysphagia.
Hosp Pract (Off Ed). 1994 Nov 15;29(11):39, 43, 47. Unique Identifier : AIDSLINE MED/95051166
Perazella MA; Sadigh M; St. Mary's Hospital, Waterbury, Conn.
Superantigens and their role in disease.
Hosp Pract (Off Ed). 1994 Nov 15;29(11):59-63, 68-70. Unique Identifier : AIDSLINE MED/95051170
Kotzin BL; National Jewish Center for Immunology and Respiratory Medicine,; Denver.
Because superantigens bind to extremely large numbers of T cells, they are useful for investigating the immune system. Moreover, they appear to have diverse pathologic roles. They may be responsible for massive cytokine release in toxic shock, activate self-reactive T cells in Kawasaki disease and rheumatoid arthritis


Analysis of the double-stranded RNA genome segments among avian reovirus field isolates.
J Virol Methods. 1994 Jun;48(1):119-22. Unique Identifier : AIDSLINE MED/95051220
Wu WY; Shien JH; Lee LH; Shieh HK; Department of Veterinary Medicine, National Chung Hsing; University, Taichung, Taiwan.
Nine isolates of avian reovirus (ARV) from both healthy birds and birds with different clinical illness and one commercially available vaccine strain were selected and characterized by analysis of the migration pattern of their genomic double-stranded RNA (dsRNA) segments following separation by polyacrylamide gel ele


Effect of methodology on detection of HIV-1/HIV-2 dual infections in Cote d'Ivoire.
J Virol Methods. 1994 Jun;48(1):23-30. Unique Identifier : AIDSLINE MED/95051221
Peeters M; Fransen K; Gershy-Damet GM; Willems B; Koffi K; Coulibaly M; Piot P; Van der Groen G; Department of Infection and Immunity, Institute of Tropical; Medicine, Antwerp, Belgium.
Dual seroreactivity to the human immunodeficiency virus (HIV) types 1 and 2 is common in Cote d Ivoire . To assess whether dual infection is the reason for dual seroreactivity, different methods for detection of HIV-1 and HIV-2 viruses were compared. PCR on primary uncultured l


Determination of the size of HIV using adenovirus type 2 as an internal length marker.
J Virol Methods. 1994 Jun;48(1):43-52. Unique Identifier : AIDSLINE MED/95051223
Gentile M; Adrian T; Scheidler A; Ewald M; Dianzani F; Pauli G; Gelderblom HR; Istituto di Virologia, Universita degli Studi di Roma La; Sapienza, Italy.
The size of a virion is a key criterion to its proper classification and may have implications in many practical aspects. Size determinations by thin section electron microscopy often result in length aberrations of more than 10% because of a number of preparative and instrumental inaccuracies, e.g. specimen shrinkage


HIV-1 gp120/160 expressing transfected cell clones to evaluate the antibody-dependent cellular cytotoxicity (ADCC) during the course of HIV-1 infection.
J Virol Methods. 1994 Jun;48(1):9-21. Unique Identifier : AIDSLINE MED/95051228
Merzouki A; Patel P; Cassol S; O'Shaughnessy M; Gill J; Arella M; Virology Research Center, Institut Armand-Frappier, Laval,; Quebec, Canada.
Transfection by electroporation of the CEM.NKR cell line with a plasmid containing the HIVNL43 gp160 gene resulted in the establishment of HIV-1 gp120/160 expressing CEM.NKR cell clones. The cell-surface expression of the recombinant viral envelope is stable and does not lead to syncytium formation among a substantial


Longitudinal evaluation of adrenocortical function in patients infected with the human immunodeficiency virus.
J Clin Endocrinol Metab. 1994 Oct;79(4):1091-6. Unique Identifier : AIDSLINE MED/95051245
Findling JW; Buggy BP; Gilson IH; Brummitt CF; Bernstein BM; Raff H; Endocrine Research Laboratory, St. Luke's Medical Center,; Milwaukee, Wisconsin 53215.
Adrenal dysfunction has been reported in patients infected with the human immunodeficiency virus (HIV). To evaluate the prevalence and degree of adrenal dysfunction in HIV-infected patients, we performed a longitudinal study in 53 ambulatory HIV patients. The plasma cortisol, aldosterone, and dehydroepiandrosterone (D


Verbal memory performance of patients with human immunodeficiency virus infection: evidence of subcortical dysfunction. The HNRC Group.
J Clin Exp Neuropsychol. 1994 Aug;16(4):508-23. Unique Identifier : AIDSLINE MED/95051334
Peavy G; Jacobs D; Salmon DP; Butters N; Delis DC; Taylor M; Massman P; Stout JC; Heindel WC; Kirson D; et al; San Diego Veterans Affairs Medical Center.
In the present study, the California Verbal Learning Test (CVLT) was administered to symptomatic HIV+ (n = 31), asymptomatic HIV+ (n = 94), and HIV-normal control (HIV-NC) (n = 40) subjects to assess the prevalence and nature of their verbal memory deficits. Symptomatic HIV+ subjects were significantly impaired relati


Seminal white blood cells and recurrent abortion.
Hum Reprod. 1994 Jun;9(6):1180-3. Unique Identifier : AIDSLINE MED/95051380
Hill JA; Anderson DJ; Polgar K; Abbott AF; Politch JA; Fearing Laboratory, Brigham and Women's Hospital, Harvard Medical; School, Boston, MA 02115.
The incidence of leukocytospermia (> 1 million white blood cells/ml semen) and concentrations of white blood cell populations in semen from men whose partners experience unexplained recurrent spontaneous abortion by conventional testing criteria are described and compared to those of men whose partners have normal rep


Facilitation of experimental allergic encephalomyelitis by irradiation and virus infection: role of inflammatory cells.
J Neuroimmunol. 1994 Nov;55(1):81-90. Unique Identifier : AIDSLINE MED/95051472
Eralinna JP; Soilu-Hanninen M; Roytta M; Ilonen J; Makela A; Salonen R; Department of Virology, University of Turku, Finland.
Infection with an avirulent strain of Semliki Forest virus (SFV-A7) facilitates the development of experimental allergic encephalomyelitis (EAE) in a genetically resistant BALB/c mouse strain. Irradiation which is necessary for EAE induction caused a decrease in the total number of lymphocytes and an increase in CD4+/


HIV-1 macrophage tropism is determined at multiple levels of the viral replication cycle.
J Clin Invest. 1994 Nov;94(5):1806-14. Unique Identifier : AIDSLINE MED/95051522
Fouchier RA; Brouwer M; Kootstra NA; Huisman HG; Schuitemaker H; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam.
The ability of HIV-1 to infect macrophages is thought to be essential in AIDS pathogenesis. We tested the ability of 19 primary virus isolates to infect monocyte-derived macrophages (MDM) from different donors. Two HIV-1 isolates were able to establish a productive infection in MDM from all donors tested, whereas eigh


Clonal expansion of CD8+ cytotoxic T lymphocytes against human T cell lymphotropic virus type I (HTLV-I) genome products in HTLV-I-associated myelopathy/tropical spastic paraparesis patients.
J Clin Invest. 1994 Nov;94(5):1830-9. Unique Identifier : AIDSLINE MED/95051525
Furukawa K; Mori M; Ohta N; Ikeda H; Shida H; Furukawa K; Shiku H; Department of Oncology, Nagasaki University School of Medicine,; Japan.
Short-term culture of peripheral blood mononuclear cells (PBMC) derived from patients with human T cell lymphotropic virus type I-associated myelopathy (HAM)/tropical spastic paraparesis resulted in dominance by DR+ activated CD8+ T cells. Variations in the T cell receptor (TCR) V alpha and V beta chains in these cell


Intercellular adhesion molecule-1 is upregulated on peripheral blood T lymphocyte subsets in dual asthmatic responders.
J Clin Invest. 1994 Nov;94(5):1840-5. Unique Identifier : AIDSLINE MED/95051526
De Rose V; Rolla G; Bucca C; Ghio P; Bertoletti M; Baderna P; Pozzi E; Department of Clinical and Biological Sciences, University of; Turin, Italy.
To examine the role of adhesion molecules in T cell recruitment and activation during allergen-induced late asthmatic response (LAR), we evaluated the expression of lymphocyte function-associated antigen-1 alpha (LFA-1 alpha) and intercellular adhesion molecule-1 (ICAM-1) on peripheral blood T lymphocyte subsets from


Quantitative analysis of CD4+ T cell function in the course of human immunodeficiency virus infection. Gradual decline of both naive and memory alloreactive T cells.
J Clin Invest. 1994 Nov;94(5):1947-52. Unique Identifier : AIDSLINE MED/95051538
Meyaard L; Otto SA; Hooibrink B; Miedema F; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Early in human immunodeficiency virus (HIV) infection CD4+ and CD8+ T cells are qualitatively affected. Loss of responses to recall antigen precedes impaired responses to allogeneic MHC and mitogens. The selective quantitative loss of memory T cells in early infection, only partially explains the observed defects. We


Macrophage-tropic variants initiate human immunodeficiency virus type 1 infection after sexual, parenteral, and vertical transmission.
J Clin Invest. 1994 Nov;94(5):2060-7. Unique Identifier : AIDSLINE MED/95051553
van't Wout AB; Kootstra NA; Mulder-Kampinga GA; Albrecht-van Lent N; Scherpbier HJ; Veenstra J; Boer K; Coutinho RA; Miedema F; Schuitemaker H; Department of Clinical Viro-Immunology, Central Laboratory of the; Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Macrophage-tropic, non-syncytium-inducing, HIV-1 variants predominate in the asymptomatic phase of infection and may be responsible for establishing infection in an individual exposed to the mixture of HIV-1 variants. Here, genotypical and phenotypical characteristics of virus populations, present in sexual, parentera


Inhibition of murine nephritogenic effector T cells by a clone-specific suppressor factor.
J Clin Invest. 1994 Nov;94(5):2093-104. Unique Identifier : AIDSLINE MED/95051557
Meyers CM; Kelly CJ; Renal-Electrolyte Division, University of Pennsylvania School of; Medicine, Philadelphia 19104.
We have used a murine model of organ-specific autoimmunity to characterize therapeutic modalities capable of down-regulating the cellular limb of the autoimmune response. Murine interstitial nephritis is an autoimmune disease mediated by tubular antigen-specific CD8+ nephritogenic effector T cells which are delayed-ty


Rapid diagnosis of cytomegalovirus encephalitis in patients with AIDS using in situ hybridisation.
J Clin Pathol. 1994 Oct;47(10):886-91. Unique Identifier : AIDSLINE MED/95051611
Musiani M; Zerbini M; Venturoli S; Gentilomi G; Borghi V; Pietrosemoli P; Pecorari M; La Placa M; Institute of Microbiology, University of Bologna, Italy.
AIMS--To evaluate the presence of cytomegalovirus ( CMV ) DNA in the cerebrospinal fluid of patients with AIDS and suspected viral encephalitis using an in situ hybridisation assay with digoxigenin labelled CMV DNA probes. METH


Management of pulmonary aspergillosis in AIDS: an emerging clinical problem.
J Clin Pathol. 1994 Sep;47(9):805-9. Unique Identifier : AIDSLINE MED/95051662
Keating JJ; Rogers T; Petrou M; Cartledge JD; Woodrow D; Nelson M; Hawkins DA; Gazzard BG; Department of HIV and Genitourinary Medicine, Chelsea and; Westminster Hospital, London.
AIMS--To review the clinical, radiographic, and therapeutic features of 11 cases of respiratory Aspergillus infection in patients with AIDS. METHODS--All induced sputum and bronchoalveolar lavage samples obtained from HIV seropositive patients between January 1985 and March 1993 were analysed for Aspergillus species.


Use of a monoclonal antibody and a DNA probe for diagnosing acute toxoplasmosis in ambiguous cases.
J Clin Pathol. 1994 Sep;47(9):853-4. Unique Identifier : AIDSLINE MED/95051672
Garberi JC; Angel SO; Paulin P; Pszenny V; Romano L; Fundacion CIMAE, Buenos Aires, Argentina.
An unusual case of cerebral toxoplasmosis in an HIV negative 11 year old child is reported. Central nervous system disease was assessed immunohistochemically in a brain biopsy specimen with TgP8--a specific monoclonal antibody against Toxoplasma gondii antigens--thus confirming IgG and IgM serology, technetium scan fi


Quantification of HIV by PCR in monocytes and lymphocytes in patients receiving antiviral treatment and low dose recombinant human granulocyte macrophage colony stimulating factor.
J Clin Pathol. 1994 Sep;47(9):855-7. Unique Identifier : AIDSLINE MED/95051673
Davison FD; Kaczmarski RS; Pozniak A; Mufti GJ; Sutherland S; Virology Department, Dulwich Hospital, London.
Neutropenia induced by antiviral treatment, in particular AZT , can be improved with recombinant human granulocyte macrophage colony stimulating factor (RHGMCSF) in HIV positive patients. However, there has been concern that this may increase the HIV l


Penicilliosis marneffei infection in AIDS.
J Am Acad Dermatol. 1994 Nov;31(5 Pt 2):843-6. Unique Identifier : AIDSLINE MED/95051753
Borradori L; Schmit JC; Stetzkowski M; Dussoix P; Saurat JH; Filthuth I; Dermatology Clinic, Hopital Cantonal Universitaire.
Penicillium marneffei infection has emerged as a new potential indicator disease for AIDS in Southeast Asia. We report two additional cases of P. marneffei infection in patients infected with HIV who had traveled to endemic areas and review the mucocutaneous features of previously reported cases. Our two patients had


Idiopathic CD4+ T-cell lymphocytopenia with verrucae, basal cell carcinomas, and chronic tinea corporis infection.
J Am Acad Dermatol. 1994 Nov;31(5 Pt 2):889-91. Unique Identifier : AIDSLINE MED/95051764
Ohashi DK; Crane JS; Spira TJ; Courrege ML; Campbell University School of Pharmacy.
Idiopathic CD4+ T lymphocytopenia should be considered in HIV-negative patients with skin lesions commonly associated with HIV infection. Patients with idiopathic CD4+ T lymphocytopenia are presumably rare, often have dermatologic lesions, always have low CD4+ T lymphocyte counts, and lack all evidence of HIV-1 infect


Cutaneous protothecosis and AIDS.
J Am Acad Dermatol. 1994 Nov;31(5 Pt 2):920-4. Unique Identifier : AIDSLINE MED/95051771
Woolrich A; Koestenblatt E; Don P; Szaniawski W; Department of Dermatology, New York Medical College, Metropolitan; Hospital Center, NY 10029.
Cutaneous protothecosis is an uncommon algal infection with a varied clinical presentation that occurs mainly in immunocompromised patients. We describe a 33-year-old Hispanic woman with AIDS who had a verrucous plaque on the dorsum of her hand. A biopsy specimen revealed organisms suggestive of Prototheca. Culture co


Neutrophilic dermatoses in HIV infection.
J Am Acad Dermatol. 1994 Dec;31(6):1045-7. Unique Identifier : AIDSLINE MED/95051775
Berger TG; Dhar A; McCalmont TH; Dermatology Service, San Francisco General Hospital, CA 94110.
Squamous cell carcinoma of the anus and rectum in homosexual men: CT findings.
J Comput Assist Tomogr. 1994 Nov-Dec;18(6):921-4. Unique Identifier : AIDSLINE MED/95051824
Radin DR; Department of Radiology, University of Southern California School; of Medicine, Los Angeles County-USC Medical Center 90033-1084.
OBJECTIVE: Homosexual men are at risk for a variety of infectious and neoplastic diseases of the anus and rectum, many of which have been reported in the radiologic literature. The purpose of this study was to describe the CT findings in homosexual men with squamous cell carcinoma of the anus and rectum, a topic that


HPV-associated epithelial atypia in oral warts in HIV+ patients.
J Cutan Pathol. 1994 Jun;21(3):217-23. Unique Identifier : AIDSLINE MED/95051848
Regezi JA; Greenspan D; Greenspan JS; Wong E; MacPhail LA; Department of Stomatology, School of Dentistry, University of; California, San Francisco 94143-0424.
Reported are oral mucosal warts (HPV common antigen-positive) from 7 adult HIV+ patients in which there was cytologic atypia and disordered growth. Lesions were papillary, white to red in color, and were located on the lip, gingiva, palate, tongue, and buccal mucosa. Histologically, the keratinocytes in the lesions ex


Caregiver burden in HIV-positive and HIV-negative partners of men with AIDS.
J Consult Clin Psychol. 1994 Aug;62(4):746-56. Unique Identifier : AIDSLINE MED/95051907
Folkman S; Chesney MA; Cooke M; Boccellari A; Collette L; Department of Medicine, University of California, San Francisco; 94105.
This study examines factors associated with caregiver burden in 82 HIV-positive (HIV+) and 162 HIV-negative (HIV-) partners of men with AIDS. We expected HIV+ caregivers to report more burden than HIV- caregivers because of the toll of their disease on their resources. HIV+ caregivers did report more burden and, compa


Knowledge of the human immunodeficiency virus among final year dental students.
J Dent. 1994 Aug;22(4):229-35. Unique Identifier : AIDSLINE MED/95051927
Gilbert AD; Nuttall NM; Department of Dental Surgery & Periodontology, University of; Dundee, Scotland, UK.
A sound basis of knowledge about HIV infection and AIDS is essential to allow students to develop as dentists who undertake appropriate measures during clinical practice. In addition, it is also likely that possessing appropriate information may instil confidence in their own ability to diagnose and then manage patien


HIV and AIDS: a survey of nurse education in the United Kingdom.
J Adv Nurs. 1994 Sep;20(3):552-9. Unique Identifier : AIDSLINE MED/95052097
McHaffie HE; Institute of Medical Ethics, University of Edinburgh Department; of Medicine, Royal Infirmary, Scotland.
A survey conducted throughout the United Kingdom examined the current provision being made to train nurses to care safely and sensitively for patients with HIV and AIDS. Problems relating to intolerance and prejudice are still commonly encountered. The study recommends that HIV and AID


The health needs of gay men: a discussion of the literature and implications for nursing.
J Adv Nurs. 1994 Sep;20(3):560-6. Unique Identifier : AIDSLINE MED/95052098
Taylor I; Robertson A; Community Drug Problem Service, Edinburgh, Scotland.
Although there is a general dearth of nursing literature on health issues specific to gay (homosexual) men, the literature reviewed shows that gay men have particular concerns related to anti-homosexual feelings anticipated and experienced from health professionals. The effects of homophobia in wider society may cause


Inhibition of human T-cell responses to house dust mite allergens by a T-cell receptor peptide.
J Allergy Clin Immunol. 1994 Nov;94(5):844-52. Unique Identifier : AIDSLINE MED/95052197
Jarman ER; Hawrylowicz CM; Panagiotopolou E; O'Hehir RE; Lamb JR; Department of Immunology, St Mary's Hospital Medical School,; Imperial College of Science, Technology and Medicine, London.
Recent analysis of the usage of T-cell receptor (TcR) beta chain variable region (V beta) gene elements by house dust mite (HDM)-reactive T cells from an atopic donor suggested that TcR-V beta 3 gene products may form a major component of the human T-cell repertoire reactive to this common allergen. In this study a pe


AIDS enteropathy: what's in a name?
J Clin Gastroenterol. 1994 Sep;19(2):154-7. Unique Identifier : AIDSLINE MED/95052421
Rabeneck L; Veterans Affairs Medical Center, Houston, Texas 77030.
The term acquired immunodeficiency syndrome (AIDS) enteropathy was first used in 1984 to refer to changes in intestinal structure and function in human immunodeficiency virus (HIV)-infected patients. Since then, confusion has arisen regarding the meaning of the term. To identify the sources of this confusion we perfor


The acquired immune deficiency syndrome: an overview for the emergency physician, Part 2.
J Emerg Med. 1994 Jul-Aug;12(4):491-7. Unique Identifier : AIDSLINE MED/95052453
Guss DA; Department of Emergency Medicine, University of California, San; Diego Medical Center 92103-8676.
Human immunodeficiency virus (HIV) affects all organ systems. Infection of the heart can manifest with evidence of myocarditis, pericarditis, or cardiomyopathy. The most common gastrointestinal symptom is diarrhea, which can result from infection with a variety of bacterial, fungal, or protozoal organisms. In about 15


Hepatitis B virus X gene product acts as a transactivator in vivo.
J Hepatol. 1994 Jul;21(1):103-9. Unique Identifier : AIDSLINE MED/95052482
Balsano C; Billet O; Bennoun M; Cavard C; Zider A; Grimber G; Natoli G; Briand P; Levrero M; Laboratoire de Genetique et Pathologie Experimentale, INSERM CJF; 90-03, Institut Cochin de Genetique Moleculaire, Paris, France.
It has previously been shown that the hepatitis B virus X gene product, pX, transactivates homologous and heterologous transcriptional regulatory sequences of viruses and various cellular genes in vitro. However, there is no evidence about the reproducibility and the relevance of this phenomenon in vivo. In this study


Pros and cons of BCG vaccination in countries with low incidence of tuberculosis.
Infect Control Hosp Epidemiol. 1994 Jul;15(7):497-9. Unique Identifier : AIDSLINE MED/95052523
Tala EO; Tala-Heikkila MM; University Central Hospital, Department of Diseases of the Chest,; Turku, Finland.
Preventive bacille Calmette-Guerin (BCG) vaccination, together with case finding and effective chemotherapy, has formed an integral part of the tuberculosis (TB) control program in most countries. In some low-incidence countries the balance of prevention has been more on the side of chemoprophylaxis than of BCG vaccin


Leishmania major-parasitized macrophages augment Th2-type T cell activation.
J Immunol. 1994 Nov 15;153(10):4378-87. Unique Identifier : AIDSLINE MED/95052603
Chakkalath HR; Titus RG; Department of Tropical Public Health, Harvard School of Public; Health, Boston, MA 02115.
We studied the ability of resident peritoneal M phi, parasitized in vitro with Leishmania major, to present Ag to three Th2-type T cell clones that are specific for non-leishmanial Ags. Results indicated that L. major-infected M phi enhanced the proliferation and IL-4 secretion of Th2 T cells in response to stimulatio


Induction by concanavalin A of specific mRNAs and cytolytic function in a CD8-positive T cell hybridoma.
J Immunol. 1994 Nov 15;153(10):4408-17. Unique Identifier : AIDSLINE MED/95052606
Gu JJ; Harriss JV; Ozato K; Gottlieb PD; Department of Microbiology, University of Texas at Austin 78712.
A previous report from this laboratory described the production of CD8+, class I-specific T cell hybridomas which developed specific cytolytic activity and the ability to secrete IL-2 upon Con A or specific Ag stimulation. Unlike normal lymphocytes or long-term CTL lin


Nerve growth factor production by lymphocytes.
J Immunol. 1994 Nov 15;153(10):4488-95. Unique Identifier : AIDSLINE MED/95052614
Santambrogio L; Benedetti M; Chao MV; Muzaffar R; Kulig K; Gabellini N; Hochwald G; Department of Pathology, New York University School of Medicine,; NY 10016.
Nerve growth factor (NGF) is a neurotrophic protein essential for the maintenance and growth of peripheral sympathetic neurons and basal forebrain cholinergic neurons. Recently, NGF has also been shown to have effects on cells of the immune system. In a search for extra neural sources of NGF, we detected NGF-specific


CD8+ T lymphocyte-mediated lysis of Chlamydia-infected L cells using an endogenous antigen pathway.
J Immunol. 1994 Nov 15;153(10):4588-95. Unique Identifier : AIDSLINE MED/95052625
Beatty PR; Stephens RS; Program in Infectious Diseases, University of California at; Berkeley 94720.
Intracellular bacterial pathogens have evolved to either grow in the nutrient-rich cytoplasm or remain sequestered within a vacuole. One potentially important selective advantage for growth within a vacuole may be evasion of cell-mediated detection and cytolysis. To address this question we used the endosomally confin


Toxoplasma gondii oral infection induces specific cytotoxic CD8 alpha/beta+ Thy-1+ gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes.
J Immunol. 1994 Nov 15;153(10):4596-603. Unique Identifier : AIDSLINE MED/95052626
Chardes T; Buzoni-Gatel D; Lepage A; Bernard F; Bout D; CIF INSERM 93-09 Immunology of Infectious Diseases, UFR of; Pharmaceutical Sciences, Tours, France.
The first line of defense of the host after primary infection by Toxoplasma gondii is the intestinal mucosal surface, which consists of epithelial cells, intraepithelial lymphocytes (IEL) (mainly of CD8 phenotype), mucus, and secretory Igs. T. gondii cysts were administered orally to CBA/J mice to determine whether pa


IFN-alpha 1 gene expression into a metastatic murine adenocarcinoma (TS/A) results in CD8+ T cell-mediated tumor rejection and development of antitumor immunity. Comparative studies with IFN-gamma-producing TS/A cells.
J Immunol. 1994 Nov 15;153(10):4604-15. Unique Identifier : AIDSLINE MED/95052627
Ferrantini M; Giovarelli M; Modesti A; Musiani P; Modica A; Venditti M; Peretti E; Lollini PL; Nanni P; Forni G; et al; Laboratory of Virology, Higher Institute of Health, Rome, Italy.
Cells from a spontaneous, invasive, and metastasizing mouse mammary adenocarcinoma (TS/A-pc) were transfected with a retroviral vector containing the mouse IFN-alpha 1 gene. TS/A clones secreting varying amounts of IFN-alpha 1 were isolated and their tumorigenicity was evaluated after s.c. or i.v. injection into immun


Cloned human CD8+ cytotoxic T lymphocytes protect human peripheral blood leukocyte-severe combined immunodeficient mice from HIV-1 infection by an HLA-unrestricted mechanism.
J Immunol. 1994 Nov 15;153(10):4826-33. Unique Identifier : AIDSLINE MED/95052649
van Kuyk R; Torbett BE; Gulizia RJ; Leath S; Mosier DE; Koenig S; Department of Immunology, Scripps Research Institute, La Jolla,; CA 92037.
The ability to infect human peripheral blood leukocyte-reconstituted severe combined immunodeficient (hu-PBL-SCID) mice with HIV has allowed evaluation of several strategies for preventing or treating infection. In one study, hu-PBL-SCID mice derived from HIV gp160-vaccinated donors were shown to resist HIV infection,


In vitro maturation of neonatal human CD8 T lymphocytes into IL-4- and IL-5-producing cells.
J Immunol. 1994 Dec 1;153(11):4862-71. Unique Identifier : AIDSLINE MED/95052652
Byun DG; Demeure CE; Yang LP; Shu U; Ishihara H; Vezzio N; Gately MK; Delespesse G; University of Montreal, Notre Dame Hospital Research Center,; Canada.
Naive CD8 T cells isolated from umbilical cord blood were examined for cytokine production and for surface phenotype before and after priming with anti-CD3 mAb in the presence of selected cytokines. On stimulation with anti-CD3 immobilized on CD32-B7-transfected L cells, naive and primed CD8 T cells release high level


Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.
J Immunol. 1994 Dec 1;153(11):4925-33. Unique Identifier : AIDSLINE MED/95052659
Harding CV; Song R; Institute of Pathology, Case Western Reserve University,; Cleveland, OH 44106.
Exogenous Ags that are processed in vacuolar endocytic compartments are generally presented by class II MHC molecules and not class I MHC (MHC-I) molecules, which conventionally present cytoplasmic or endogenous Ags. Accordingly, i.v. immunization of C57BL/6 mice with soluble OVA did not elicit a CD8 T cell response.


Two forms of the mb-1 gene transcript in cattle.
J Immunol. 1994 Dec 1;153(11):5127-32. Unique Identifier : AIDSLINE GENBANK/D16459
Youn HY; Goitsuka R; Okuda M; Watari T; Tsujimoto H; Hasegawa A; Department of Veterinary Internal Medicine, Faculty of; Agriculture, University of Tokyo, Japan.
We have isolated two forms of bovine mb-1 cDNA clones from a cDNA library of a bovine leukemia virus-infected B-lymphoblastoid cell line. The nucleotide sequence analysis of these cDNA clones indicated that the shorter form of cDNA had a 119-bp deletion that precisely corresponded to the exon III domain of the human a


IL-12 is both required and prognostic in vivo for T helper type 1 differentiation in murine candidiasis.
J Immunol. 1994 Dec 1;153(11):5167-75. Unique Identifier : AIDSLINE MED/95052684
Romani L; Mencacci A; Tonnetti L; Spaccapelo R; Cenci E; Puccetti P; Wolf SF; Bistoni F; Department of Experimental Medicine and Biochemical Sciences,; University of Perugia, Italy.
In murine models of systemic candidiasis, healing and nonhealing patterns of disease are associated with preferential expansion of Th1 and Th2 cells, respectively. As previous studies have shown IL-12 to be expressed transcriptionally in healer mice and to be required for Th1 development in vitro, this cytokine might


Effect of MHC class I and CD8 cell deficiency on experimental autoimmune myasthenia gravis pathogenesis.
J Immunol. 1994 Dec 1;153(11):5330-5. Unique Identifier : AIDSLINE MED/95052701
Shenoy M; Kaul R; Goluszko E; David C; Christadoss P; Department of Microbiology and Immunology, University of Texas; Medical Branch, Galveston 77555.
MHC class I and CD8+ cell deficiency have either prevented systemic lupus erythematosus-like disease in mice or enhanced type I diabetes in nonobese diabetic mice. To study the involvement of MHC class I and class I-restricted CD8+ T cells in the induction of a classical Ab-mediated disease, experimental autoimmune my


Measurement of the anti-HIV agent 2',3'-didehydro-2',3'-dideoxythymidine (D4T) by competitive ELISA.
J Immunol Methods. 1994 Nov 10;176(1):103-10. Unique Identifier : AIDSLINE MED/95052704
Ferrua B; Tran TT; Quaranta JF; Kubar J; Roptin C; Condom R; Durant J; Guedj R; Laboratoire de Pharmacologie Experimentale et Clinique, Faculte; de Medecine, Chemin de Valombrose, Nice, France.
2 ,3 -didehydro-2 ,3 -dideoxythymidine (D4T) is a thymidine analogue with potent anti-HIV activity in vitro and is currently being investigated therapeutically in patients with advanced HIV infection. We describe a first one-step competitive ELISA method developed for D4T measurement. Anti-D4T rabbit antibodies were r


Detection of the products of polymerase chain reaction by an ELISA system based on an ion sensitive field effect transistor.
J Immunol Methods. 1994 Nov 10;176(1):45-52. Unique Identifier : AIDSLINE MED/95052710
Tsuruta H; Matsui S; Hatanaka T; Namba T; Miyamoto K; Nakamura M; Biosensor Research Laboratories Co., Ltd., Okayama, Japan.
An ELISA system was developed using a pH sensitive ISFET (pH-FET) as a detector, a pipette tip as a solid phase, and urease as a detecting enzyme. Double stranded PCR products with digoxigenin and biotin at both terminals were obtained by using digoxigenin- and biotin-labeled primers. 1 microliters of the PCR solution


Primary in vitro immunization with multimeric synthetic peptides of HIV-1 envelope glycoproteins: generation of neutralizing human monoclonal antibodies.
J Immunol Methods. 1994 Nov 10;176(1):9-22. Unique Identifier : AIDSLINE MED/95052714
Fraisier C; Ebersold A; Blomberg J; Desgranges C; INSERM U271, Unite de Recherche sur les Hepatites, le SIDA et; les Retrovirus humains, Lyon, France.
Peripheral blood lymphocytes from healthy HIV-1 seronegative donors were immunized in vitro with the following synthetic peptides: (i) an octameric poly-L-lysine conjugated peptide of the HIV-1MN V3 loop and (ii) a resin bound synthetic peptide aa642-665 of HIV-1 gp41. Lymphoblastoid cell lines (LCL) were obtained by


HIV makes its way in the islands of the Bay of Bengal (Andaman and Nicobar), India [letter]
J Infect. 1994 Jul;29(1):116-8. Unique Identifier : AIDSLINE MED/95052747
Sarkar K; Sarkar S; Deb BC; Shah WA; Rashid M; Nagra JS; Panda S; Naik TN; Manna B
Mother-to-child transmission of human immunodeficiency virus type 1: report from the Nairobi Study [see comments]
J Infect Dis. 1994 Nov;170(5):1134-40. Unique Identifier : AIDSLINE MED/95052830
Datta P; Embree JE; Kreiss JK; Ndinya-Achola JO; Braddick M; Temmerman M; Nagelkerke NJ; Maitha G; Holmes KK; Piot P; et al; World Health Organization Collaborating Centre for Research and; Training in Sexually Transmitted Diseases, Department of Medical; Microbiology, University of Nairobi, Kenya.
Mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) is a significant problem in countries with endemic HIV-1 infection. Between 1986 and 1991, 365 children of HIV-1-infected mothers and 363 control children were studied in Kenya . The overall risk of transmiss


Neutralizing antibodies against sequential autologous human immunodeficiency virus type 1 isolates after seroconversion.
J Infect Dis. 1994 Nov;170(5):1141-7. Unique Identifier : AIDSLINE MED/95052831
Tsang ML; Evans LA; McQueen P; Hurren L; Byrne C; Penny R; Tindall B; Cooper DA; Centre for Immunology, St. Vincent's Hospital, Sydney, Australia.
The emergence of human immunodeficiency virus type 1 (HIV-1) variants with different sensitivities to serum neutralization and biologic phenotype was studied for 2-5 years after primary HIV-1 infection in 5 subjects. In 3 subjects, the initial virus isolate from seroconversion could be neutralized by autologous serum,


B and T cell function parameters during zidovudine treatment of human immunodeficiency virus-infected patients.
J Infect Dis. 1994 Nov;170(5):1148-56. Unique Identifier : AIDSLINE MED/95052832
Zamarchi R; Panozzo M; Del Mistro A; Barelli A; Borri A; Amadori A; Chieco-Bianchi L; Institute of Oncology, University of Padova, Italy.
The aim of this study was to assess the effects of zidovudine on B cell dysregulation in human immunodeficiency virus (HIV)-infected patients and the phenomenon of gp 120/anti-gp 120 antibody complex adhesion to CD4+ cells. Compared with pretherapy figures, zidovudine treatment was not associated with a change in spon


Genotypic and phenotypic analysis of human immunodeficiency virus type 1 isolates from patients on prolonged stavudine therapy.
J Infect Dis. 1994 Nov;170(5):1157-64. Unique Identifier : AIDSLINE MED/95052833
Lin PF; Samanta H; Rose RE; Patick AK; Trimble J; Bechtold CM; Revie DR; Khan NC; Federici ME; Li H; et al; Department of Virology and Antiviral Clinical Research,; Bristol-Myers Squibb Pharmaceutical Research Institute,; Wallingford, Connecticut 06492.
Development of stavudine resistance was studied using human immunodeficiency virus type 1 isolates from 13 patients treated with stavudine for 18-22 months. Drug sensitivity testing on 11 of these pre- and posttherapy isolates identified only 2 posttr


Zidovudine and dideoxycytidine differ in their effects on human immunodeficiency virus-induced pathologic activation of the immune system. AIDS Clinical Trial Research Group 047.
J Infect Dis. 1994 Nov;170(5):1165-71. Unique Identifier : AIDSLINE MED/95052834
Liu M; Fahey JL; Aziz N; Cumberland WG; Skowron G; Merigan T; Center for Interdisciplinary Research in Immunology and Disease,; School of Medicine, UCLA 90024-1747.
When zidovudine and dideoxycytidine ( ddC ) were given on schedules of 1 week on drug and 1 week off, results differed substantially in effects on HIV (human immunodeficiency virus type 1)-induced immune activation. Zidovudine (200 mg every 4 h) caused


Application of branched DNA signal amplification to monitor human immunodeficiency virus type 1 burden in human plasma.
J Infect Dis. 1994 Nov;170(5):1172-9. Unique Identifier : AIDSLINE MED/95052835
Dewar RL; Highbarger HC; Sarmiento MD; Todd JA; Vasudevachari MB; Davey RT Jr; Kovacs JA; Salzman NP; Lane HC; Urdea MS; Department of Microbiology, Georgetown University Medical Center,; Washington, DC.
A branched DNA (bDNA)-based quantitation of plasma human immunodeficiency virus type 1 (HIV-1) RNA was used to monitor the virologic status of 102 patients (29-906 CD4 cells/mm3) enrolled in clinical trials of antiretroviral and immune-based therapies. Virion-associated RNA was measurable in plasma of 74% of patients


Use of recombinant soluble CD4 Pseudomonas exotoxin, a novel immunotoxin, for treatment of persons infected with human immunodeficiency virus.
J Infect Dis. 1994 Nov;170(5):1180-8. Unique Identifier : AIDSLINE MED/95052836
Davey RT Jr; Boenning CM; Herpin BR; Batts DH; Metcalf JA; Wathen L; Cox SR; Polis MA; Kovacs JA; Falloon J; et al; National Institute of Allergy and Infectious Diseases, National; Institutes of Health, Bethesda, Maryland 20892.
Single and multiple doses of sCD4-PE40, a soluble recombinant fusion toxin selectively toxic to gp120-expressing cells, were evaluated in persons infected with human immunodeficiency virus type 1 (HIV-1). Seventeen of 24 patients who completed a single-dose safety trial were given either 1, 5, 10, or 15 micrograms/kg


Hypertriglyceridemic serum, very low density lipoprotein, and iron enhance Mycobacterium avium replication in human macrophages.
J Infect Dis. 1994 Nov;170(5):1248-55. Unique Identifier : AIDSLINE MED/95052845
Douvas GS; May MH; Pearson JR; Lam E; Miller L; Tsuchida N; Department of Basic Sciences and Oral Research, School of; Dentistry, University of Colorado Health, Sciences Center, Denver; 80262.
The growth of Mycobacterium avium 7497, serovar 4, in cultured human macrophages is enhanced by Fe3+ and serum lipids over 7 days. Iron (1-80 micrograms/mL) added to macrophages cultured in normal serum resulted in 10-fold increases in growth. If iron-supplemented macrophages were cultured in serum from hypertriglycer


Detection of cytomegalovirus DNA in serum correlates with clinical cytomegalovirus retinitis in AIDS [see comments]
J Infect Dis. 1994 Nov;170(5):1271-4. Unique Identifier : AIDSLINE MED/95052850
Hansen KK; Ricksten A; Hofmann B; Norrild B; Olofsson S; Mathiesen L; Department of Infectious Diseases, Hvidovre Hospital, Denmark.
The high sensitivity of nested polymerase chain reaction (PCR) offers the possibility of rapid detection of cytomegalovirus ( CMV ) DNA in serum. Five consecutive serum samples were examined from 52 human immunodeficiency virus


Diagnosis of human cytomegalovirus infection of the nervous system by pp65 detection in polymorphonuclear leukocytes of cerebrospinal fluid from AIDS patients.
J Infect Dis. 1994 Nov;170(5):1275-9. Unique Identifier : AIDSLINE MED/95052851
Revello MG; Percivalle E; Sarasini A; Baldanti F; Furione M; Gerna G; Virus Laboratory, Institute of Infectious Diseases, University of; Pavia, Italy.
Detection of human cytomegalovirus (HCMV) pp65 in cerebrospinal fluid (CSF) polymorphonuclear leukocytes (PMNL) was investigated in 32 CSF samples from 25 AIDS patients with neurologic symptoms. HCMV pp65-positive PMNL were detected in 9 CSF samples from 3 patients with polyradicul


Rapid increases in load of human immunodeficiency virus correlate with early disease progression and loss of CD4 cells in vertically infected infants.
J Infect Dis. 1994 Nov;170(5):1279-84. Unique Identifier : AIDSLINE MED/95052852
Dickover RE; Dillon M; Gillette SG; Deveikis A; Keller M; Plaeger-Marshall S; Chen I; Diagne A; Stiehm ER; Bryson Y; Department of Pediatrics, UCLA School of Medicine.
The relationship between viral burden, timing of transmission, and clinical progression was investigated in 110 children at risk for vertical human immunodeficiency virus (HIV) infection using quantitative polymerase chain reaction, coculture, and immune complex-dissociated p24 antigen assay. In a cross-sectional stud


Incidence of clinical AIDS conditions in a cohort of homosexual men with CD4+ cell counts < 100/mm3. Multicenter AIDS Cohort Study.
J Infect Dis. 1994 Nov;170(5):1284-7. Unique Identifier : AIDSLINE MED/95052853
Bacellar H; Munoz A; Hoover DR; Phair JP; Besley DR; Kingsley LA; Vermund SH; Johns Hopkins School of Public Health, Baltimore, MD 21205.
Incidence rates of AIDS illnesses are described among patients with


Clinical and immunologic responses to human immunodeficiency virus (HIV) type 1SF2 gp120 subunit vaccine combined with MF59 adjuvant with or without muramyl tripeptide dipalmitoyl phosphatidylethanolamine in non-HIV-infected human volunteers.
J Infect Dis. 1994 Nov;170(5):1288-91. Unique Identifier : AIDSLINE MED/95052854
Kahn JO; Sinangil F; Baenziger J; Murcar N; Wynne D; Coleman RL; Steimer KS; Dekker CL; Chernoff D; AIDS Program, San Francisco General Hospital, CA 94110.
A phase 1 study of 42 non-human immunodeficiency virus type 1 (HIV)-infected volunteers was initiated to determine the safety and immunogenicity of an HIV subunit vaccine consisting of recombinant envelope gp120 derived from HIVSF2 (rgp120SF2) combined with a novel adjuvant, MF59, with or without the immunomodulator m


Detection of drug resistance mutations in the human immunodeficiency virus type 1 (HIV-1) pol gene: differences in semen and blood HIV-1 RNA and proviral DNA.
J Infect Dis. 1994 Nov;170(5):1292-5. Unique Identifier : AIDSLINE MED/95052855
Kroodsma KL; Kozal MJ; Hamed KA; Winters MA; Merigan TC; Center for AIDS Research, Stanford University Medical Center,; California 94305.
Different tissues or body fluids in which human immunodeficiency virus type 1 (HIV-1) can reside may contain viruses with distinct characteristics. Sixteen HIV-1-infected patients receiving zidovudine or didanosine were studied cross-sectionally and 1 patient who switched from zidovudine to didanosine was followed seq


Occurrence of human immunodeficiency virus type 1 (HIV-1)-specific cytolytic T cell activity in apparently uninfected children born to HIV-1-infected mothers.
J Infect Dis. 1994 Nov;170(5):1296-9. Unique Identifier : AIDSLINE MED/95052856
De Maria A; Cirillo C; Moretta L; Department of Infectious Diseases, University of Genoa, Italy.
Human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) activity against different viral antigens, including env, gag/pol, and nef, was detected in peripheral blood lymphocytes of as many as 25% of uninfected children born to HIV-1-infected mothers. The relatively high frequency of this findi


Effectiveness of aminosidine (paromomycin) sulfate in chronic Cryptosporidium diarrhea in AIDS patients: an open, uncontrolled, prospective clinical trial.
J Infect Dis. 1994 Nov;170(5):1349-50. Unique Identifier : AIDSLINE MED/95052871
Scaglia M; Atzori C; Marchetti G; Orso M; Maserati R; Orani A; Novati S; Olliaro P
[Phase III clinical trial of KRN8601 (rhG-CSF) for neutropenia in patients with human immunodeficiency virus infection]
Kansenshogaku Zasshi. 1994 Sep;68(9):1093-104. Unique Identifier : AIDSLINE MED/95052975
Kimura S; Shimada K; Matsuda J; Gohchi K; Fukutake K; Fukue H; Okubo T; Ishigatsubo Y; Yamada K; Koitabashi Y; et al; Department of Infection Diseases and Applied Immunology,; University of Tokyo.
The efficacy of KRN8601 for neutropenia associated with HIV infection was evaluated in 24 patients. KRN8601 was infused intravenously at a dosage of 200 micrograms/m2 for 14 consecutive days. Neutrophil counts recovered in 19 (90.5%) out of 21 evaluable patients by KRN8601 treatment. The concomitant myelosuppressive a


[Detection of cytomegalovirus (CMV) antigen for rapid diagnosis and monitoring of CMV diseases in AIDS]
Kansenshogaku Zasshi. 1994 Sep;68(9):1105-12. Unique Identifier : AIDSLINE MED/95052976
Hanabusa H; Matsuda F; Tanaka Y; Uesugi T; Ota T; Sato T; Nomori H; Minematsu T; Minamishima Y; Mori R; Department of Pediatrics, Ogikubo Hospital.
Ten to forty percent of the patients with acquired immunodeficiency syndrome (AIDS) develop sight- or life-threatening cytomegalovirus ( CMV ) infections. In some patients with AIDS, CMV is detected in the bronchoalveolar lavag


[Role of cellular proteases in virus infection: influenza virus and HIV infection]
Seikagaku. 1994 Aug;66(8):1130-4. Unique Identifier : AIDSLINE MED/95053031
Kido H; Division of Enzyme Chemistry, Institute for Enzyme Research,; University of Tokushima.
[Quantitation of HTLV-I proviral copies of infected cells in pregnant HTLV-I carriers and its correlation with vertical infection]
Nippon Sanka Fujinka Gakkai Zasshi. 1994 Sep;46(9):867-74. Unique Identifier : AIDSLINE MED/95053066
Tanigawa T; Department of Obstetrics and Gynecology, Nara Medical University.
Using colony formation in poly-L-lysine chamber slides and the polymerase chain reaction (PCR), we quantitated the number of human T lymphotropic virus type-I (HTLV-I) infected cells and proviral copies in peripheral blood lymphocytes from 25 pregnant HTLV-I carriers. The number of HTLV-I proviral copies in 0.25 micro


Phenotype and cytokine expression of intralesional cells in borderline leprosy.
Int J Lepr Other Mycobact Dis. 1994 Sep;62(3):380-8. Unique Identifier : AIDSLINE MED/95053091
McClean K; G/Yesus E; Cenini P; Demissie A; Amare G; Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
We studied the cytokine profiles and cellular compositions in the lesions of borderline lepromatous (BL) and borderline tuberculoid (BT) leprosy patients in order to ascertain the immunological distinctions between these two groups. Using a modified, reliable, noninvasive, suction-induced blister technique to sample l


[Malignant proliferative disorders of the lymphatic systems and viruses]
Nippon Naika Gakkai Zasshi. 1994 Jun 10;83(6):885-9. Unique Identifier : AIDSLINE MED/95053235
Taguchi H; Miyoshi I
[Aids-related lymphoma]
Nippon Naika Gakkai Zasshi. 1994 Jun 10;83(6):954-7. Unique Identifier : AIDSLINE MED/95053248
Mori S
[Infection and management: AIDS]
Nippon Naika Gakkai Zasshi. 1994 Jul 10;83(7):1133-40. Unique Identifier : AIDSLINE MED/95053270
Mori H
[Infections likely to develop in immunocompromised hosts: Pneumocystis carinii pneumonia]
Nippon Naika Gakkai Zasshi. 1994 Jul 10;83(7):1157-62. Unique Identifier : AIDSLINE MED/95053274
Nakata K; Shimada K
Small intestinal HIV-associated enteropathy: evidence for panintestinal enterocyte dysfunction.
J Lab Clin Med. 1994 Nov;124(5):652-9. Unique Identifier : AIDSLINE MED/95053329
Carlson S; Yokoo H; Craig RM; Department of Medicine, Northwestern University Medical School,; Chicago, IL.
To characterize the absorptive defect of AIDS enteropathy, we have used a D-xylose kinetic model of proximal absorption and correlated these findings with Schilling s test for cobalamin absorption, measurements of distal intestinal function. In addition, we compared findings between duodenal and jejunal biopsy and asp


Neopterin production by HIV-1-infected mononuclear phagocytes.
J Leukoc Biol. 1994 Nov;56(5):650-3. Unique Identifier : AIDSLINE MED/95053384
Dukes CS; Matthews TJ; Rivadeneira ED; Weinberg JB; Department of Medicine, Duke University Medical Center, Durham,; North Carolina.
Neopterin is a pteridine produced by human mononuclear phagocytes, usually in response to interferon-gamma (IFN-gamma) stimulation. Increasing serum levels of neopterin correlate with clinical progression to AIDS in HIV-infected people, but the factors that contribute to these elevated levels are not established. We p


Cellular composition of Corynebacterium pseudotuberculosis pyogranulomas in sheep.
J Leukoc Biol. 1994 Nov;56(5):666-70. Unique Identifier : AIDSLINE MED/95053387
Pepin M; Pittet JC; Olivier M; Gohin I; CNEVA Sophia Antipolis, Laboratoire de Pathologie des Petits; Ruminants et des Abeilles, Biot, France.
The cellular composition of 46 pyogranulomas experimentally induced with Corynebacterium pseudotuberculosis in sheep was determined by immunohistochemistry. Lesions localized in inoculation sites or draining lymph nodes consisted of macrophage and lymphocyte layers distributed around a necrotic center and surrounded b


Disseminated cutaneous cytomegalic inclusion disease resembling prurigo nodularis in a HIV-infected patient: a case report and literature review.
J Med Assoc Thai. 1993 Oct;76(10):581-4. Unique Identifier : AIDSLINE MED/95053453
Chiewchanvit S; Thamprasert K; Siriunkgul S; Department of Internal Medicine, Faculty of Medicine, Chiang Mai; University, Thailand.
Cytomegalovirus infection is common disease but most of the healthy patients are asymptomatic. Cytomegalovirus infection is a serious problem in immunocompromised patients particularly in acquired immunodeficiency syndrome. About 90 per cent of patients with AIDS develop active cytomeg


Pneumocystis carinii pneumonia in infants born to anti HIV positive mothers.
J Med Assoc Thai. 1993 Nov;76(11):641-6. Unique Identifier : AIDSLINE MED/95053465
Mingvanish S; Pediatrics Department, Saraburi Hospital, Thailand.
Infants generally acquire HIV form mother during gestation, or delivery by contact with maternal blood and body fluids or breast feeding. At Saraburi Hospital, from January 1989 to December 1992, there were 17,766 mothers who gave birth, 80 anti HIV positive mothers were included. Up to now, four cases of PCP have bee


AIDS in Spain: lessons learned from a public health disaster [editorial]
J Epidemiol Community Health. 1994 Aug;48(4):331-2. Unique Identifier : AIDSLINE MED/95053568
Alvarez-Dardet C; Hernandez Aguado I
Slow progression to AIDS in intravenous drug users infected with HIV in Norway.
J Epidemiol Community Health. 1994 Aug;48(4):383-7. Unique Identifier : AIDSLINE MED/95053578
Eskild A; Magnus P; Sohlberg C; Kittelsen P; Olving JH; Teige B; Skullerud K; Department of Epidemiology, National Institute of Public Health,; Oslo, Norway.
STUDY OBJECTIVE--To study the rate of progression to AIDS and to death, and the causes of death among intravenous drug users in Norway . DESIGN--This was a prospective study. The study population was followed from diagnosis of HIV seropositivity until death or the end of the study p


AIDS and behavioural risk factors in women in inner city Baltimore: a comparison of telephone and face to face surveys.
J Epidemiol Community Health. 1994 Aug;48(4):412-8. Unique Identifier : AIDSLINE MED/95053583
Nebot M; Celentano DD; Burwell L; Davis A; Davis M; Polacsek M; Santelli J; Division of Behavioural Sciences and Health Education, Johns; Hopkins School of Hygiene and Public Health, Baltimore, MD.
STUDY OBJECTIVE--The study aimed to investigate the influence the mode of administration of a questionnaire (telephone or face to face) on reports of sexual behaviour and attitudes of HIV risk among woman of reproductive age. DESIGN--Two cross sectional surveys--one, a modified random digit dialing telephone survey, t


IV drug users: changes in risk behaviour according to HIV status in a national survey in Spain.
J Epidemiol Community Health. 1994 Oct;48(5):459-63. Unique Identifier : AIDSLINE MED/95053595
Delgado-Rodriguez M; de la Fuente L; Bravo MJ; Lardelli P; Barrio G; Department of Preventive Medicine, School of Medicine, Avenida de; Madrid, Granada, Spain.
STUDY OBJECTIVE--To determine whether HIV positive intravenous drug users (IVDUs) who were receiving outpatient treatment for opiate and cocaine abuse or dependence used practices aimed at reducing the spread of HIV. DESIGN--Cross sectional study of behaviour and HIV serostatus in IVDUs. SETTING--A nationwide sample,


Heterosexual transmission of hepatitis C virus and the possible role of coexistent human immunodeficiency virus infection in the index case. A multicentre study of 423 pairings.
J Intern Med. 1994 Nov;236(5):515-9. Unique Identifier : AIDSLINE MED/95053671
Soto B; Rodrigo L; Garcia-Bengoechea M; Sanchez-Quijano A; Riestra S; Arenas JI; Andreu J; Rodriguez M; Emparanza JI; Torres Y; et al; Viral Hepatitis and AIDS Study Group, Virgen del Rocio University; Hospital, Seville, Spain.
OBJECTIVES. To define the role that sexual transmission plays in the spread of hepatitis C virus (HCV) infection, and to examine the influence of coexistent human immunodeficiency virus (HIV) infection on this mode of transmission. DESIGN. A multicentre, seroprevalence study of anti-HCV performed in the stable heteros


Fever of unknown origin in HIV-infected patients: a critical analysis of a retrospective series of 57 cases.
J Intern Med. 1994 Nov;236(5):529-35. Unique Identifier : AIDSLINE MED/95053673
Bissuel F; Leport C; Perronne C; Longuet P; Vilde JL; Department of Infectious and Tropical Diseases, Bichat-Claude; Bernard Hospital, Paris, France.
OBJECTIVES. The aim of the study was to assess the incidence and aetiology of fever of unknown origin in human immunodeficiency virus (HIV)-infected patients, and to evaluate the usefulness of the main diagnostic procedures. DESIGN. A retrospective study. SETTING AND SUBJECTS. We reviewed the records of 270 HIV-infect


Human T cell lymphotropic virus type I and cutaneous T cell leukemia/lymphoma [published erratum appears in J Exp Med 1995 Jan 1;181(1):441]
J Exp Med. 1994 Nov 1;180(5):1581-5. Unique Identifier : AIDSLINE MED/95053689
Hall WW; Laboratory of Medical Virology, Rockefeller University, New York.
Altered glycosylation of leukosialin, CD43, in HIV-1-infected cells of the CEM line.
J Exp Med. 1994 Nov 1;180(5):1609-17. Unique Identifier : AIDSLINE MED/95053693
Lefebvre JC; Giordanengo V; Limouse M; Doglio A; Cucchiarini M; Monpoux F; Mariani R; Peyron JF; Laboratoire de Virologie, Faculte de Medecine, Hopital de; Cimiez, France.
CD43 (leukosialin, gpL115, sialophorin) is a major sialoglycoprotein widely expressed on hematopoietic cells that is defective in the congenital immunodeficiency Wiskott-Aldrich syndrome. It is thought to play an important role in cell-cell interactions and to be a costimulatory molecule for T lymphocyte activation. U


Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis.
J Exp Med. 1994 Nov 1;180(5):1649-63. Unique Identifier : AIDSLINE GENBANK/L19437
Banki K; Colombo E; Sia F; Halladay D; Mattson DH; Tatum AH; Massa PT; Phillips PE; Perl A; Department of Pathology, State University of New York College of; Medicine, Syracuse 13210.
Although the etiology of multiple sclerosis (MS) is unknown, there is compelling evidence that its pathogenesis is mediated through the immune system. Molecular mimicry, i.e., crossreactivity between self-antigens and viral proteins, has been implicated in the initiation of autoimmunity and MS. Based on homology to hu


Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras.
J Exp Med. 1994 Nov 1;180(5):1817-27. Unique Identifier : AIDSLINE MED/95053712
Tary-Lehmann M; Lehmann PV; Schols D; Roncarolo MG; Saxon A; Hart and Louise Lyon Laboratory, Department of Medicine,; University of California at Los Angeles 90024.
Injecting human peripheral blood mononuclear cells into severe combined immunodeficient (SCID) mice results in long-term engraftment of human lymphocytes, of which > 98% are phenotypically mature, activated T cells. Here we have characterized the human T cells that populate such hu-PBL-SCID chimeras. We report that th


Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function.
J Exp Med. 1994 Nov 1;180(5):1911-20. Unique Identifier : AIDSLINE MED/95053720
Yeung RS; Penninger JM; Kundig TM; Law Y; Yamamoto K; Kamikawaji N; Burkly L; Sasazuki T; Flavell R; Ohashi PS; et al; Department of Immunology, Ontario Cancer Institute, University of; Toronto, Canada.
To reconstitute the human immune system in mice, transgenic mice expressing human CD4 and human major histocompatibility complex (MHC) class II (DQw6) molecules in an endogenous CD4- and CD8-deficient background (mCD4/8-/-), after homologous recombination, have been generated. We report that expression of human CD4 mo


The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells.
J Exp Med. 1994 Nov 1;180(5):1937-42. Unique Identifier : AIDSLINE MED/95053723
Gray JD; Hirokawa M; Horwitz DA; Department of Medicine, University of Southern California School; of Medicine, Los Angeles 90033.
CD8+ T cells have suppressor effector functions, but the mechanisms involved in the generation of this activity are poorly understood. We report that natural killer (NK) cells have an important role in the acquisition of this function. CD8+ cells induce NK cells to produce transforming growth factor-beta (TGF-beta) wh


The specific recognition by macrophages of CD8+,CD45RO+ T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections.
J Exp Med. 1994 Nov 1;180(5):1943-7. Unique Identifier : AIDSLINE MED/95053724
Akbar AN; Savill J; Gombert W; Bofill M; Borthwick NJ; Whitelaw F; Grundy J; Janossy G; Salmon M; Department of Clinical Immunology, Royal Free Hospital School of; Medicine, London, United Kingdom.
During viral infections, CD8+,CD45RO+ T populations expand. These primed cells express abundant levels of cytoplasmic granules that contain perforin and TIA-1. Recent work has suggested that the majority of this CD8+ population downregulates Bcl-2 protein expression and is destined to undergo apoptosis. In this study


Persistence of human T cell lymphotropic virus type 1 (HTLV-1) sequences in peripheral blood mononuclear cells from patients with mycosis fungoides [published erratum appears in J Exp Med 1995 Jan 1;181(1):441]
J Exp Med. 1994 Nov 1;180(5):1973-8. Unique Identifier : AIDSLINE MED/95053729
Manca N; Piacentini E; Gelmi M; Calzavara P; Manganoni MA; Glukhov A; Gargiulo F; De Francesco M; Pirali F; De Panfilis G; et al; Institute of Microbiology of Brescia University, Spedali Civili; of Brescia, Italy.
Mycosis fungoides (MF) is a rare form of cutaneous T cell lymphoma suspected of having a viral etiology. As in adult T cell leukemia, the virus involved may be human T lymphotropic virus type 1 (HTLV-1). We cultured the peripheral blood mononuclear cells (PBMC) of 29 patients with MF HTLV-1 seronegative by enzyme-link


Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.
J Exp Med. 1994 Dec 1;180(6):2089-99. Unique Identifier : AIDSLINE MED/95053743
Zal T; Volkmann A; Stockinger B; Department of Molecular Immunology, National Institute for; Medical Research, Mill Hill, London, United Kingdom.
Transgenic mice expressing a major histocompatibility complex class II-restricted T cell receptor with specificity for a natural self-antigen, the fifth component of complement, were generated to analyze the mechanism of tolerance induction to a blood-borne self-protein. In the absence of C5 protein thymocytes from T


In vivo treatment with interleukin 12 protects mice from immune abnormalities observed during murine acquired immunodeficiency syndrome (MAIDS).
J Exp Med. 1994 Dec 1;180(6):2199-208. Unique Identifier : AIDSLINE MED/95053754
Gazzinelli RT; Giese NA; Morse HC 3rd; Section of Immunobiology and Cell Biology, National Institute of; Allergy and Infectious Diseases, National Institutes of Health,; Bethesda, Maryland 20892.
Lymphoproliferation, chronic B cell activation resulting in hypergammaglobulinemia, and profound immunodeficiency are prominent features of a retrovirus-induced syndrome designated murine acquired immunodeficiency syndrome (MAIDS). In vivo treatment of infected mice with recombinant interleukin 12 (IL-12) beginning at


Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes.
J Exp Med. 1994 Dec 1;180(6):2209-18. Unique Identifier : AIDSLINE MED/95053755
Ikonomidis G; Paterson Y; Kos FJ; Portnoy DA; Department of Microbiology, University of Pennsylvania School of; Medicine, Philadelphia 19104-6076.
Listeria monocytogenes is a facultative intracellular pathogen that grows in the cytoplasm of infected host cells. We examined the capacity of L. monocytogenes to introduce influenza nucleoprotein (NP) into the class I pathway of antigen presentation both in vitro and in vivo. Recombinant L. monocytogenes secreting a


Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression.
J Exp Med. 1994 Dec 1;180(6):2371-6. Unique Identifier : AIDSLINE MED/95053774
Matsuda M; Salazar F; Petersson M; Masucci G; Hansson J; Pisa P; Zhang QJ; Masucci MG; Kiessling R; Microbiology and Tumor Biology Center, Karolinska Institute,; Stockholm, Sweden.
Interleukin 10 (IL-10) is a cytokine with a variety of reported effects including inhibition of monocyte major histocompatibility complex (MHC) class II-dependent antigen presentation, type 1 helper T cell cytokine production, and inhibition of T cell proliferation. Herein we report the effect of IL-10 pretreatment on


CD30 expression by CD8+ T cells producing type 2 helper cytokines. Evidence for large numbers of CD8+CD30+ T cell clones in human immunodeficiency virus infection.
J Exp Med. 1994 Dec 1;180(6):2407-11. Unique Identifier : AIDSLINE MED/95053780
Manetti R; Annunziato F; Biagiotti R; Giudizi MG; Piccinni MP; Giannarini L; Sampognaro S; Parronchi P; Vinante F; Pizzolo G; et al; Division of Clinical Immunology and Allergy, University of; Florence, Italy.
A large panel of CD8+ T cell clones generated from peripheral blood lymphocytes (PBL) of healthy donors or human immunodeficiency virus (HIV)-infected individuals were assessed for both cytokine secretion profile and CD30 expression and release. The great majority of CD8+ T cell clones generated from healthy individua


Drugs of abuse and infectious diseases.
J Fla Med Assoc. 1994 Jul;81(7):485-7. Unique Identifier : AIDSLINE MED/95053847
Specter S; Department of Medical Microbiology and Immunology, University of; South Florida College of Medicine.
The association of increased severity of infectious diseases and recreational drug abuse can be traced to the last century with the finding that alcoholics often suffered more severely from bacterial pneumonia than nonalcoholics. More recently there have been numerous associations with use of opiate and other psychoge


Localization of viral protein X in simian immunodeficiency virus macaque strain and analysis of its packaging requirements.
J Gen Virol. 1994 Nov;75 ( Pt 11):2955-62. Unique Identifier : AIDSLINE MED/95053880
Liska V; Spehner D; Mehtali M; Schmitt D; Kirn A; Aubertin AM; Unite INSERM 74, Faculte de Medecine, Universite Louis; Pasteur, Strasbourg, France.
Simian immunodeficiency virus (SIV) and human immunodeficiency virus type 2 (HIV-2) encode the accessory viral protein X (Vpx) known to be incorporated into virions in amounts comparable to those of the Gag proteins. The localization of Vpx within SIVmac-infected HUT-78 cells and SIVmac virions was studied by immunoel


Extensive C-terminal deletion in human immunodeficiency virus type 1 Env glycoprotein arising after long-term culture of chronically infected cells.
J Gen Virol. 1994 Nov;75 ( Pt 11):2963-75. Unique Identifier : AIDSLINE MED/95053881
Zaides V; Yagello M; Veselovskaya T; Schmitt D; Rykova L; Fenouillet E; Gluckman JC; CNRS URA 1463, CERVI, Faculte de Medecine Pitie-Salpetriere,; Paris, France.
Human immunodeficiency virus type 1 (HIV-1) chronically infected (CI) cell lines were established from HIV-1HIB/LAI-infected MT-4 cells that survived acute infection. The HIV env gene expressed in the two long-term cultured cell lines differed from that of the lines cultured for shorter periods, by coding for a glycop


Inhibition of protein synthesis by the human immunodeficiency virus type 1 nef gene product.
J Gen Virol. 1994 Nov;75 ( Pt 11):2977-84. Unique Identifier : AIDSLINE MED/95053882
Poulin L; Fauchon M; Darveau A; Levy JA; Centre de Recherche du CHUL, Universite Laval, Quebec, Canada.
During productive infection of human T lymphocytes in cell culture, the expression of human immunodeficiency virus type 1 is temporally regulated by virus-encoded regulatory proteins. Among these Nef, whose function has not been clearly elucidated, is thought to alter CD4+ T cells. We examined the possibility that the


Comparative morphology of Gag protein structures produced by mutants of the gag gene of human immunodeficiency virus type 1.
J Gen Virol. 1994 Nov;75 ( Pt 11):2985-97. Unique Identifier : AIDSLINE MED/95053883
Hockley DJ; Nermut MV; Grief C; Jowett JB; Jones IM; Electron Microscopy and Photography Section, National Institute; for Biological Standards and Control, Potters Bar. Hertfordshire,; U.K.
Six mutants that differ in the extent of their carboxyterminal sequences and two deletion mutants of the gag gene of HIV-1 have been characterized morphologically following their expression in Spodoptera frugiperda cells using recombinant baculoviruses. Electron microscopy has revealed distinct morphological forms of


Molecular determinants of the V3 loop of human immunodeficiency virus type 1 glycoprotein gp120 responsible for controlling cell tropism.
J Gen Virol. 1994 Nov;75 ( Pt 11):3249-53. Unique Identifier : AIDSLINE MED/95053912
Chavda SC; Griffin P; Han-Liu Z; Keys B; Vekony MA; Cann AJ; Department of Microbiology and Immunology, University of; Leicester, U.K.
We and others have identified the major determinant of cell tropism in human immunodeficiency virus type 1 (HIV-1) as the V3 loop of glycoprotein gp120. We have conducted a detailed study of two molecularly cloned isolates of HIV-1, HIVJR-CSF and HIVNL4-3, that differ in their tropism for immortalized CD4+ cell lines,


Inhibition of human T cell leukaemia virus type I long terminal repeat expression by DNA methylation: implications for latency.
J Gen Virol. 1994 Nov;75 ( Pt 11):3255-9. Unique Identifier : AIDSLINE MED/95053913
Cassens S; Ulrich U; Beimling P; Simon D; Abteilung Virologie, Robert Koch-Institut, Berlin, Germany.
Human T cell leukaemia virus type I (HTLV-I) provirus DNA was found to be methylated in patients with adult T cell leukaemia. We have therefore examined the possibility that DNA methylation might contribute to HTLV-I latency. In vitro methylation of HTLV-I long terminal repeat (LTR)-chloramphenicol acetyltransferase o


Vitreous fluid sampling and viral genome detection for the diagnosis of viral retinitis in patients with AIDS.
J Med Virol. 1994 Aug;43(4):336-40. Unique Identifier : AIDSLINE MED/95053927
Mitchell SM; Fox JD; Tedder RS; Gazzard BG; Lightman S; Department of Clinical Science, Moorfields Eye Hospital, London,; England.
Cytomegalovirus ( CMV ) causes severe necrotizing retinitis in patients with the acquired immune deficiency syndrome (AIDS) and other herpesviruses have been implicated in the acute retinal necrosis syndrome (ARN), seen in both the immunocompetent and the immunosu


The high prevalence of unsafe sexual behaviors among acute psychiatric inpatients. Implications for AIDS prevention.
J Nerv Ment Dis. 1994 Nov;182(11):661-6. Unique Identifier : AIDSLINE MED/95053964
Menon AS; Pomerantz S; Harowitz S; Appelbaum D; Nuthi U; Peacock E; Cohen C; Department of Psychiatry, Albert Einstein Medical Center,; Philadelphia, Pennsylvania.
We conducted a study to determine the prevalence and sociodemographic distribution of unsafe sexual behaviors among psychiatric inpatients and to investigate an association between crack cocaine use and these behaviors. Two hundred thirty-nine patients admitted to two Philadelphia hospitals during a 12-month period we


Electroencephalography.
J Neurol Neurosurg Psychiatry. 1994 Nov;57(11):1308-19. Unique Identifier : AIDSLINE MED/95054103
Binnie CD; Prior PF; Department of Clinical Neurophysiology, The Maudsley Hospital,; Denmark Hill, London, UK.
Notwithstanding recent advances in neuroimaging, EEG remains a major technique for investigation of the brain. Its main applications are in assessment of cerebral function rather than for detecting structural abnormalities. The principal clinical applications are in epilepsy, states of altered consciousness including


Allolymphocytotoxic antibodies in sera from HTLV-I-associated myelopathy/tropical spastic paraparesis patients--putative anti-HLA antibodies.
J Neurol Sci. 1994 Aug;125(1):62-9. Unique Identifier : AIDSLINE MED/95054191
Godoy AJ; Itoyama Y; Tokunaga K; Hara H; Kawaga Y; Kiyokawa H; Maeda Y; Goto I; Department of Neurology, Kyushu University, Fukuoka, Japan.
Thirty-one HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients and 34 asymptomatic carriers were studied in order to investigate the presence of anti-lymphocyte antibodies in their sera. 32% of the patients produced allolymphocytotoxic antibodies reactive to peripheral blood lymphocytes (mainl


Apoptosis of T lymphocytes in the spinal cord lesions in HTLV-I-associated myelopathy: a possible mechanism to control viral infection in the central nervous system.
J Neuropathol Exp Neurol. 1994 Nov;53(6):617-24. Unique Identifier : AIDSLINE MED/95054204
Umehara F; Nakamura A; Izumo S; Kubota R; Ijichi S; Kashio N; Hashimoto K; Usuku K; Sato E; Osame M; Third Department of Internal Medicine, Faculty of Medicine,; Kagoshima University, Japan.
Immunocytochemical staining of spinal cords from five autopsied patients with HAM/TSP was performed using the monoclonal antibody TIA-1, a marker of cytotoxic T lymphocytes (CTL). Many TIA-1+, CD8+ cells are distributed in active inflammatory lesions. The number of TIA-1+ cells is related to the amount of HTLV-I provi


A shape- and chemistry-based docking method and its use in the design of HIV-1 protease inhibitors.
J Comput Aided Mol Des. 1994 Jun;8(3):231-42. Unique Identifier : AIDSLINE MED/95054226
DesJarlais RL; Dixon JS; Department of Physical and Structural Chemistry, SmithKline; Beecham Pharmaceuticals, King of Prussia, PA 19406-0939.
The program DOCK [1,2] has been used successfully to identify molecules which will bind to a specified receptor [3]. The original method ranks molecules based on their shape complementarity to the receptor site and relies on the chemist to bring the appropriate electrostatic or hydrogen bond properties into the molecu


Proficiency of internal medicine residents in outpatient care of patients with HIV infection.
J Gen Intern Med. 1994 Aug;9(8):459-61. Unique Identifier : AIDSLINE MED/95054569
Schultz P; Bindman AB; Cooke M; Division of General Internal Medicine, San Francisco General; Hospital, California 94110.
To determine internal medicine residents knowledge of HIV care, the authors conducted a survey of residents from four internal medicine programs in the San Francisco Bay area. On a knowledge test, the mean score was 42.4/55, 77% correct. The residents performed relatively worse on questions regarding didanosine and z


Care of patients with acquired immune deficiency syndrome in rural areas.
J Intraven Nurs. 1994 Jul-Aug;17(4):206-9. Unique Identifier : AIDSLINE MED/95054703
Lockman-Samkowiak J
Providing home intravenous care to patients with acquired immune deficiency syndrome (AIDS) in rural areas can be quite a challenge. The possibility of poor access to care, limited hospital resources, or a shortage of pertinent education available to the nursing staff may combine to make this specialized form of care


Passive hyperimmune therapy: a viable treatment option for the patient with acquired immune deficiency syndrome.
J Intraven Nurs. 1994 Jul-Aug;17(4):214-6. Unique Identifier : AIDSLINE MED/95054705
Raven NC
New drugs and therapies are continually emerging in an effort to delay the progression of human immunodeficiency virus (HIV)-positive status to acquired immune deficiency syndrome (AIDS). One such treatment is passive hyperimmune therapy (PHT), which was first researched and subsequently published in 1988. Passive hyp


Update on mycobacterial issues for the acquired immune deficiency syndrome era.
J Intraven Nurs. 1994 Jul-Aug;17(4):217-9. Unique Identifier : AIDSLINE MED/95054706
Batt MD
Patients with immunosuppression are especially susceptible to Mycobacterium tuberculosis and Mycobacterium avium-intracellularae, (also known as Mycobacterium avium Complex). Mycobacterium tuberculosis is the causative agent of pulmonary and extrapulmonary manifestations of tuberculosis, whereas the M. avium-intracell


Growth as a prognostic indicator in children with human immunodeficiency virus infection treated with zidovudine. AIDS Clinical Trials Group Protocol 043 Study Group.
J Pediatr. 1994 Nov;125(5 Pt 1):728-33. Unique Identifier : AIDSLINE MED/95054776
McKinney RE Jr; Wilfert C; Department of Pediatrics, Duke University Medical School, Durham,; North Carolina 27710.
OBJECTIVE: To assess measures of growth as prognostic indicators in response to zidovudine treatment in children with symptomatic human immunodeficiency virus infection. METHODS: We retrospectively assessed data from AIDS Clinical Trials Group Protocol 043, an open-label, phase II study of oral zidovudine therapy (180


Benefit of early fitting of hearing aids [letter; comment]
J Pediatr. 1994 Nov;125(5 Pt 1):844. Unique Identifier : AIDSLINE MED/95054799
Sutton GJ; Stokes J
Primary versus secondary and central versus consequence-related control in HIV-positive men.
J Pers Soc Psychol. 1994 Sep;67(3):540-7. Unique Identifier : AIDSLINE MED/95054960
Thompson SC; Nanni C; Levine A; Department of Psychology, Pomona College, Claremont, California; 91711.
Two dimensions of perceived control (primary vs. secondary and central vs. consequence-related) were examined in a sample of 104 HIV-positive men. Two hypotheses regarding the use of primary control (acting to achieve specific outcomes) and secondary control (acceptance) were supported: The use of both primary and sec


Nucleotide binding by the HIV-1 integrase protein in vitro.
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1215-23. Unique Identifier : AIDSLINE MED/95054988
Lipford JR; Worland ST; Farnet CM; Dana-Farber Cancer Institute, Department of Pathology, Harvard; Medical School, Boston, Massachusetts 02115.
Recombinant human immunodeficiency virus type 1 (HIV-1) integrase was shown to bind ATP and other nucleoside triphosphates and nucleotide analogs in vitro. Cross-linking of ATP and the photoaffinity analog 8-azido-ATP to integrase occurred in a UV dose-dependent manner. Covalent binding of ATP to integrase was also ac


A rapid and reliable assay to enumerate CD4+ T lymphocytes in whole blood.
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1224-7. Unique Identifier : AIDSLINE MED/95054989
Ferreira OC Jr; Suleiman G; Brites C; Novoa P; Piovesana M; Suleiman J; Kanayama RH; Russel TR; Zwerner R; Harrington W Jr; et al; Instituto de Infectologia Emilio Ribas, Sao Paulo, Brazil.
We compared the performance of a rapid and simple anti-CD4 antibody-coated microsphere assay with flow cytometry and immunofluorescence for quantitation of absolute count of CD4+ T lymphocytes. A longitudinal evaluation of CD4+ T lymphocytes by flow cytometry and microsphere assay in 10 human immunodeficiency virus (H


Effects of vif mutations on cell-free infectivity and replication of simian immunodeficiency virus.
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1228-36. Unique Identifier : AIDSLINE MED/95054990
Park IW; Myrick K; Sodroski J; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, MA 02115.
To investigate the function of the Vif protein of the simian immunodeficiency virus (SIV), mutations were introduced into the SIVmac239 vif gene without affecting the reading frames of other overlapping genes. The phenotypes of these mutant viruses were examined with respect to viral replication and the expression and


Antiretroviral therapy is associated with a decrease in unintegrated HIV-1 DNA in pediatric patients.
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1237-41. Unique Identifier : AIDSLINE MED/95054991
Donovan RM; Bush CE; Smereck SM; Moore E; Cohen F; Saravolatz LD; Department of Infectious Diseases, Henry Ford Hospital, Detroit,; Michigan 48202.
Good markers for monitoring the efficacy of antiretroviral therapy in children do not currently exist. This study examined the effect of antiretroviral therapy on human immunodeficiency virus (HIV-1) unintegrated DNA (uDNA), integrated DNA (iDNA), percent uDNA, immune complex dissociated (ICD) p24 antigenemia, and pla


Thrush and fever as measures of immunocompetence in HIV-1-infected men.
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1242-9. Unique Identifier : AIDSLINE MED/95054992
Kirby AJ; Munoz A; Detels R; Armstrong JA; Saah A; Phair JP; Johns Hopkins School of Public Health, Baltimore, Maryland.
The occurrence of Pneumocystis carinii pneumonia (PCP) in human immunodeficiency virus type 1 (HIV-1)-infected individuals with high CD4+ counts indicates poor immunologic function. Thrush and persistent fever, easily recognized clinically, are potential measures of immunocompetence. This analysis establishes the comp


Health care delivery, zidovudine use, and survival of women and men with AIDS.
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1250-62. Unique Identifier : AIDSLINE MED/95054993
Turner BJ; Markson LE; McKee LJ; Houchens R; Fanning T; Center for Research in Medical Education and Health Care, Thomas; Jefferson University, Philadelphia, PA.
The aim of this study was to define predictors of survival for women and men after AIDS diagnosis. We examined health care delivery and drug therapy in the year before AIDS diagnosis for continuously enrolled New York State Medicaid beneficiaries with AIDS in 1988-1990. We examined the association of these factors wit


Resistance to HIV-1 infection. Multicenter AIDS Cohort Study.
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1263-9. Unique Identifier : AIDSLINE MED/95054994
Detels R; Liu Z; Hennessey K; Kan J; Visscher BR; Taylor JM; Hoover DR; Rinaldo CR Jr; Phair JP; Saah AJ; et al; University of California, Los Angeles, School of Public Health; 90024-1772.
Men from the Multicenter AIDS Cohort Study were classified as susceptible and resistant to HIV infection. Resistant men were still HIV antibody negative in 1993 and were estimated to have had > 45 different anal intercourse partners (median, 92; range, 46-504) in the 2.5 years before visit 2 (1985). Susceptible men we


Incidence of HIV-1 infection among young men in Thailand.
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1270-5. Unique Identifier : AIDSLINE MED/95054995
Carr JK; Sirisopana N; Torugsa K; Jugsudee A; Supapongse T; Chuenchitra C; Nitayaphan S; Singharaj P; McNeil JG; Henry M. Jackson Foundation, Rockville, Maryland 20852.
Royal Thai Army (RTA) enlistees were tested for HIV-1 seropositivity prospectively in order to explore their feasibility as a cohort in an HIV-1 preventive vaccine efficacy trial. The 17,615 seronegative enlistees, virtually all 21-year-old men, contributed 10,409 person-years (p-y) of follow-up. Cohorts were enlisted


Trends in risk behavior and HIV seroprevalence in heterosexual injection drug users in San Francisco, 1986-1992.
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1276-81. Unique Identifier : AIDSLINE MED/95054996
Watters JK; Department of Family and Community Medicine, School of Medicine,; University of California, San Francisco 94143-1304.
We examine changes and stability in risk behaviors and HIV-1 seroprevalence among heterosexual injection drug users (IDUs) over 13 cross-sectional surveys, 1986-1992. Interviews (n = 5,956) were conducted with IDUs in street settings and drug detoxification clinics over 6.5 years, and respondents were tested for HIV-1


Seroprevalence of HIV-1 and syphilis antibodies in blood donors in Gonder, Ethiopia, 1989-1993.
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1282-5. Unique Identifier : AIDSLINE MED/95054997
Assefa A; Rahlenbeck S; Molla K; Alemu S; Department of Microbiology, Gonder College of Medical Sciences,; Addis Abeba University, Ethiopia.
Data are presented from serologic screening for human immunodeficiency virus type 1 (HIV-1) in all blood donors (n = 3,696) in Gonder, Ethiopia , between 1989 and 1993. The crude seroprevalence was 10.6% in men (326 of 3,066) and 11.9% in women (75 of 630). Seroprevalence in male


Autoantibodies to nucleosomes in HIV-1-infected patients [letter]
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1286-7. Unique Identifier : AIDSLINE MED/95054998
Viard JP; Chabre H; Bach JF
HTLV-I-associated myelopathy in Venezuela [letter]
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1289-90. Unique Identifier : AIDSLINE MED/95055000
Zabaleta M; Peralta J; Birges J; Bianco N; Echeverria de Perez G
Changes in HIV risk behavior among French heterosexuals: patterns of sexual monogamy and condom use between 1988 and 1991 [letter]
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1290-1. Unique Identifier : AIDSLINE MED/95055001
Guiguet M; LePont F; Retel O; Valleron AJ
Improved detection of HTLV-II antibody using a whole viral lysate-based EIA [letter]
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1291-2. Unique Identifier : AIDSLINE MED/95055002
Kline RL; Vlahov D; Quinn TC
T lymphocyte homeostasis after HIV seroconversion [letter; comment]
J Acquir Immune Defic Syndr. 1994 Dec;7(12):1292-3. Unique Identifier : AIDSLINE MED/95055003
Phillips AN; Sabin CA; Elford J; Bofill M; Janossy G; Lee CA
Clinical consensus on the management of HIV infection and disease. Proceedings of a roundtable. San Francisco, California, March 18-19, 1994.
J Acquir Immune Defic Syndr. 1994;7 Suppl 2:S1-49. Unique Identifier : AIDSLINE MED/95055004
Initiation of antiretroviral therapy in HIV infection: a review of interstudy consistencies.
J Acquir Immune Defic Syndr. 1994;7 Suppl 2:S12-22; discussion S22-3. Unique Identifier : AIDSLINE MED/95055005
Volberding PS; Graham NM; University of California, San Francisco.
A number of clinical trials have explored the optimal dosage for antiretroviral therapy and, in various ways, the optimal time, in terms of stage of human immunodeficiency virus (HIV) disease, at which treatment should begin. Some studies have shown that treatment with zidovudine results in a delay in progression to m


Pathogenicity and diversity of HIV and implications for clinical management: a review.
J Acquir Immune Defic Syndr. 1994;7 Suppl 2:S2-10; discussion S10-1. Unique Identifier : AIDSLINE MED/95055006
Saag MS; Hammer SM; Lange JM; UAB AIDS Outpatient Clinic, University of Alabama at Birmingham; 35294-2050.
Genetic variation of human immunodeficiency virus (HIV) over time is an important consideration in long-term antiretroviral therapy, in all likelihood affecting the course of HIV disease and its response to antiretroviral therapy. Viral replication persists throughout HIV disease, and viral burden is correlated with d


Issues in combination antiretroviral therapy: a review.
J Acquir Immune Defic Syndr. 1994;7 Suppl 2:S24-35; discussion S35-7. Unique Identifier : AIDSLINE MED/95055007
Hammer SM; Kessler HA; Saag MS; Research Virology Laboratory, New England Deaconess Hospital,; Boston, MA 02215.
High viral burden and replication persist during all phases of human immunodeficiency virus (HIV) disease. Although monotherapy has yielded considerable benefits, these benefits are neither absolute nor durable. Combination therapy has multiple goals: to reduce viral replication and burden; to relieve drug toxicity; t


AIDS dementia complex: a review.
J Acquir Immune Defic Syndr. 1994;7 Suppl 2:S38-48; discussion S48-9. Unique Identifier : AIDSLINE MED/95055008
Portegies P; Department of Neurology, Academisch Medisch Centrum, Amsterdam,; The Netherlands.
AIDS dementia complex (ADC) is a constellation of cognitive, motor, and behavioral dysfunctions frequently observed in persons with AIDS. Estimates of its prevalence vary. ADC may occur at any stage of AIDS but is usually associated with later stages of disease. Its severity varies


Cocaine interacts with macrophages to modulate mesangial cell proliferation.
J Pharmacol Exp Ther. 1994 Oct;271(1):311-8. Unique Identifier : AIDSLINE MED/95055094
Mattana J; Gibbons N; Singhal PC; Department of Medicine, Long Island Jewish Medical Center, New; Hyde Park, New York.
Human immunodeficiency virus infection is associated with the development of focal segmental glomerulosclerosis (FSGS). The majority of these patients with renal disease, however, are also cocaine abusers, but it is unknown what role cocaine may play in the development of focal segmental glomerulosclerosis. We underto


Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. I. Cell differentiation determines sensitivity to prostaglandins and virus infection.
J Pharmacol Exp Ther. 1994 Nov;271(2):1086-95. Unique Identifier : AIDSLINE MED/95055146
Lacal PM; Puglianiello A; Bonmassar E; D'Onofrio C; Department of Experimental Medicine and Biochemical Sciences,; University of Rome Tor Vergata, Italy.
Human myeloid cell lines at different stages of differentiation (K562, HL60 and U937) were used to analyze the permissivity of the myelomonocytic lineage to acute infection with human T-cell leukemia virus type-I (HTLV-I) after cell-to-cell transmission and to evaluate the effect of cyclopentenone prostaglandins (PG)A


Effects of cyclopentenone prostaglandins on myeloid cells during early infection with HTLV-I. II. Regulation of synthesis of inducible p72 heat shock protein.
J Pharmacol Exp Ther. 1994 Nov;271(2):1096-102. Unique Identifier : AIDSLINE MED/95055147
Lacal PM; Amici C; Bonmassar E; D'Onofrio C; Department of Experimental Medicine and Biochemical Sciences,; University of Rome Tor Vergata, Italy.
Differentiation of cells of myelomonocitic lineage influences both cellular permissivity to infection with human T-cell leukemia virus type I after cell-to-cell virus transmission and sensitivity to the antiproliferative effect of cyclopentenone prostaglandins (PG)A1 and PGJ2. Growth inhibition and control of infectio


In situ hybridization and the polymerase chain reaction (PCR) in the analysis of biopsies and exfoliative cytology specimens for definitive diagnosis of oral hairy leukoplakia (OHL).
J Oral Pathol Med. 1994 Aug;23(7):302-8. Unique Identifier : AIDSLINE MED/95055274
Mabruk MJ; Flint SR; Toner M; Balluz I; Coleman D; Sullivan D; Atkins GJ
The definitive diagnosis of oral hairy leukoplakia (OHL) demands that Epstein-Barr virus (EBV) is demonstrated in the lesional tissue, since the histopathological features on conventional light microscopy are not pathognomonic. We have investigated the possible use of polymerase chain reaction (PCR) technology in reac


Anticardiolipin antibodies in pediatric patients with human immunodeficiency virus.
J Rheumatol. 1994 Jul;21(7):1344-6. Unique Identifier : AIDSLINE MED/95055480
Carreno L; Monteagudo I; Lopez-Longo FJ; Gonzalez C; Perez T; Rodriguez Mahou M; Samson J; Lapointe N; Servicio de Reumatologia, Hospital Universitario Gregorio; Maranon, Madrid, Spain.
OBJECTIVE. To study the presence of IgG and IgM anticardiolipin antibodies (aCL) in children with human immunodeficiency virus (HIV) infection and to determine their prevalence and clinical significance. METHODS. We studied 34 children with HIV infection: 26 patients were classified P-2, and 8 were P-1 according to th


TCR V beta selection from a DRB1*401*0101 patient with rheumatoid arthritis complicated by a CD8+ T cell infiltrated rheumatoid pericarditis [letter]
J Rheumatol. 1994 Jul;21(7):1373-5. Unique Identifier : AIDSLINE MED/95055493
Travaglio-Encinoza A; Anaya JM; d'Angeac AD; Sany J; Reme T
Design, synthesis, and conformational analysis of a novel macrocyclic HIV-protease inhibitor.
J Med Chem. 1994 Oct 28;37(22):3684-92. Unique Identifier : AIDSLINE MED/95055535
Podlogar BL; Farr RA; Friedrich D; Tarnus C; Huber EW; Cregge RJ; Schirlin D; Marion Merrell Dow Research Institute, Cincinnati, Ohio; 45215-6300.
Design modifications to the lead HIV-PR inhibitor 1 (MDL 73,669, Ki = 5 nM) have been postulated based on a computational model of the 1/HIV-PR complex. A novel macrocyclic inhibitor 8 (MDL 104,168) wherein the P1 and P3 side chains of the original acyclic inhibitor have been joined retains good biological activity (K


Synthesis and structure-activity relationships of a series of penicillin-derived HIV proteinase inhibitors: heterocyclic ring systems containing P1' and P2' substituents.
J Med Chem. 1994 Oct 28;37(22):3707-16. Unique Identifier : AIDSLINE MED/95055538
Kitchin J; Bethell RC; Cammack N; Dolan S; Evans DN; Holman S; Holmes DS; McMeekin P; Mo CL; Nieland N; et al; Department of Medicinal Chemistry, Glaxo Research and Development; Limited, Greenford, Middlesex, United Kingdom.
As an extension of our earlier work based upon a single penicillin-derived thiazolidine moiety we have found that the decahydroisoquinoline grouping, also present in Ro 31-8959, is an effective replacement for one of the thiazolidine units in C2 symmetric penicillin-derived dimers. Reaction of racemic epoxide 6 with [


Candida krusei: biology, epidemiology, pathogenicity and clinical manifestations of an emerging pathogen.
J Med Microbiol. 1994 Nov;41(5):295-310. Unique Identifier : AIDSLINE MED/95055614
Samaranayake YH; Samaranayake LP; Department of Pathology (Oral), Faculty of Medicine, University; of Hong Kong.
Early reports of Candida krusei in man describe the organism as a transient, infrequent isolate of minor clinical significance inhabiting the mucosal surfaces. More recently it has emerged as a notable pathogen with a spectrum of clinical manifestations such as fungaemia, endophthalmitis, arthritis and endocarditis, m


Early activation of PBMC and appearance of antiviral CD8+ cells influence the prognosis of SIV-induced disease in rhesus macaques.
J Med Primatol. 1994 Feb-May;23(2-3):108-16. Unique Identifier : AIDSLINE MED/95055638
Joag SV; Adams RJ; Foresman L; Galbreath D; Zink MC; Pinson DM; McClure H; Narayan O; Laboratory of Viral Pathogenesis, Marion Merrell Dow Foundation,; Kansas University Medical Center, Kansas City 66160-7424.
We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen-stimulated PBMC, while in phase 3, virus was recovered from


Kinetics of primary SIV infection in lymph nodes.
J Med Primatol. 1994 Feb-May;23(2-3):117-24. Unique Identifier : AIDSLINE MED/95055639
Chakrabarti L; Cumont MC; Montagnier L; Hurtrel B; Unite d'Oncologie Virale, Institut Pasteur, Paris, France.
The very early stages of SIV infection in lymph nodes of rhesus monkeys were characterized by in situ hybridization. Massive viral replication was detected in macrophages and lymphocytes during the first week of infection. In a second phase, SIV RNA concentrated in the developing germinal centers, and colocalized with


Cellular immune responses in rhesus macaques infected rectally with low dose simian immunodeficiency virus.
J Med Primatol. 1994 Feb-May;23(2-3):125-30. Unique Identifier : AIDSLINE MED/95055640
Salvato MS; Emau P; Malkovsky M; Schultz KT; Johnson E; Pauza CD; Dept. of Pathology and Laboratory Medicine, University of; Wisconsin, Madison 53707.
Monkeys infected rectally with low dose simian immunodeficiency virus (SIV) were resistant to high dose challenge with SIV. Peripheral blood mononuclear cells (PBMC) from two of four challenged monkeys were unable to support SIV replication in vitro unless cultures were depleted of CD8+ lymphocytes. Monkeys that had s


Antiviral activity of primate gamma delta T lymphocytes isolated by magnetic cell sorting.
J Med Primatol. 1994 Feb-May;23(2-3):131-5. Unique Identifier : AIDSLINE MED/95055641
Wallace M; Gan YH; Pauza CD; Malkovsky M; Department of Medical Microbiology and Immunology, University of; Wisconsin Medical School, Madison 53706.
The exposure of human or rhesus monkey peripheral blood mononuclear cells (PBMCs) to interleukin 2 ( IL-2 ) in vitro resulted in a selective outgrowth of gamma delta lymphocytes. Using positive selection by monoclonal antibodies and magnetic beads, gamma delta T lymphocy


Viral genetic determinants in SIVsmmPBj pathogenesis.
J Med Primatol. 1994 Feb-May;23(2-3):136-45. Unique Identifier : AIDSLINE MED/95055642
Novembre FJ; Saucier MM; Hirsch VM; Johnson PR; McClure HM; Division of Pathobiology and Immunobiology, Yerkes Regional; Primate Research Center, Emory University, Atlanta, GA.
A variant simian immunodeficiency virus (SIV) from sooty mangabeys, SIVsmmPBj, induces an acutely lethal disease in pigtailed macaques (Macaca nemestrina). This study further characterizes the viral genetic determinants involved in this acutely lethal disease. We have generated chimeric molecular clones constructed be


Cell type-dependence for Vpu function.
J Med Primatol. 1994 Feb-May;23(2-3):146-50. Unique Identifier : AIDSLINE MED/95055643
Geraghty RJ; Talbot KJ; Callahan M; Harper W; Panganiban AT; McArdle Laboratory for Cancer Research, University of Wisconsin,; Madison 53706.
Human immunodeficiency virus type 1 Vpu has been shown to facilitate virus release from HeLa cells. We demonstrated that Vpu expression is not required for efficient virus release from Cos 1 and CV-1 cells. A yeast GAL4 transcriptional activation system was used to screen for cellular proteins that may interact with V


An Hsp60 related protein is associated with purified HIV and SIV.
J Med Primatol. 1994 Feb-May;23(2-3):151-4. Unique Identifier : AIDSLINE MED/95055644
Bartz SR; Pauza CD; Ivanyi J; Jindal S; Welch WJ; Malkovsky M; Dept. of Medical Microbiology and Immunology, Univ. of Wisconsin,; Madison 53706.
The possible physical association of heat shock proteins (Hsp s) with immunodeficiency viruses (HIV and SIV) has been examined. The virions were purified by a) polyethylene glycol (PEG) precipitation and Sepharose 4B filtration, b) PEG precipitation and centrifugation over a Renografin gradient, or c) PEG precipitatio


Adaptation of HIV-1 to pigtailed macaques.
J Med Primatol. 1994 Feb-May;23(2-3):155-63. Unique Identifier : AIDSLINE MED/95055645
Gartner S; Liu Y; Polonis V; Lewis MG; Elkins WR; Hunter EA; Miao J; Corts KJ; Eddy GA; Henry M. Jackson Foundation Research Laboratory, Rockville, MD; 20850.
In vitro infectivity experiments were performed to assess the susceptibility of cells from various monkey species to HIV-1. T lymphocytes from pigtailed macaques, but not those from rhesus or cynomolgus monkeys, were susceptible to infection, but virus expression was limited. The majority of HIV-1 isolates were unable


Passive immunization of macaques against SIV infection.
J Med Primatol. 1994 Feb-May;23(2-3):164-74. Unique Identifier : AIDSLINE MED/95055646
Gardner MB; Rosenthal A; Jennings M; Yee JA; Antipa L; MacKenzie M; Department of Medical Pathology, UC, Davis.
Passive immunization with plasma from an inactivated-whole SIVmac vaccine protected monkey conferred complete or partial protection to rhesus macaques challenged intravenously 4 or 18 hours later with 10 AID50 of homologous cell-free virus. In contrast, passive immunization with inactivated plasma or purified immunogl


Comparison of the efficacy of AZT and PMEA treatment against acute SIVmne infection in macaques.
J Med Primatol. 1994 Feb-May;23(2-3):175-83. Unique Identifier : AIDSLINE MED/95055647
Tsai CC; Follis KE; Grant R; Sabo A; Nolte R; Bartz C; Bischofberger N; Benveniste R; University of Washington Regional Primate Research Center,; Seattle 99022.
The antiretroviral drugs azidothymidine ( AZT ) and 9-(-2-phosphonyl-methoxyethyl)adenine (PMEA) were individually tested for prevention of simian immunodeficiency virus (SIVmne) infection in macaques (Macaca fascicularis). Macaques were pretreated with


Annual updated survey of worldwide HIV, SIV, and SHIV challenge studies in vaccinated nonhuman primates.
J Med Primatol. 1994 Feb-May;23(2-3):184-225. Unique Identifier : AIDSLINE MED/95055648
Warren JT; Dolatshahi M; EMMES Corporation, Potomac, MD 20854.
Nonhuman Primate Models for AIDS VI. Symposium proceedings. Madison, Wisconsin, 19-22 September 1993.
J Med Primatol. 1994 Feb-May;23(2-3):65-225. Unique Identifier : AIDSLINE MED/95055649
Primary cultures of rhesus placental syncytiotrophoblasts are permissive for SIV infection.
J Med Primatol. 1994 Feb-May;23(2-3):66-74. Unique Identifier : AIDSLINE MED/95055650
Golos TG; Krugner-Higby LA; Williams CS; Fisher JM; Johnson KJ; Durning M; Schultz KT; Wisconsin Regional Primate Research Center, University of; Wisconsin, Madison 53715-1299.
Primary cultures of rhesus syncytiotrophoblasts incubated with SIVdeltaB670, SIVmac251, or SIVmac239 produced readily detectable virus in the supernatant for up to three weeks after infection. At four weeks, cells generally failed to release virus but placental cell lysates and placental cells cocultured for 24 hours


Immunization with whole inactivated vaccine protects from infection by SIV grown in human but not macaque cells.
J Med Primatol. 1994 Feb-May;23(2-3):75-82. Unique Identifier : AIDSLINE MED/95055651
Goldstein S; Elkins WR; London WT; Hahn A; Goeken R; Martin JE; Hirsch VM; Immunodeficiency Viruses Section, NIAID, NIH, Rockville, MD; 20852.
Homologous SIVsm stocks were generated by passage of a macaque isolate of SIVsm (SIVsm/E660) in human CEM x 174 cells or macaque peripheral blood mononuclear cells. Macaques were immunized with whole inactivated SIV vaccine consisting of virus generated by transfection of CEM x 174 cells with the SIVsmH4 clone and wer


Infectivity of titered doses of simian immunodeficiency virus clone E11S inoculated intravenously into rhesus macaques (Macaca mulatta).
J Med Primatol. 1994 Feb-May;23(2-3):83-8. Unique Identifier : AIDSLINE MED/95055652
Benveniste RE; Roodman ST; Hill RW; Knott WB; Ribas JL; Lewis MG; Eddy GA; Laboratory of Viral Carcinogenesis, National Cancer Institute,; Frederick, MD 21702-1201.
The macaque infectious dose (MID) of a single-cell clone of simian immunodeficiency virus isolated from a pig-tailed macaque (SIV/Mne clone E11S) was determined in rhesus macaques (Macaca mulatta). Twenty-one macaques were inoculated with 10-fold dilutions of the virus stock (three or four animals per dose). The virol


Efficacy of inactivated whole HIV-2 vaccines with various adjuvants in cynomolgus monkeys.
J Med Primatol. 1994 Feb-May;23(2-3):89-94. Unique Identifier : AIDSLINE MED/95055653
Putkonen P; Nilsson C; Walther L; Ghavamzadeh L; Hild K; Broliden K; Biberfeld G; Thorstensson R; Department of Immunology, Swedish Institute for Infectious; Disease Control, Karolinska Institute, Stockholm.
Twenty-one cynomolgus monkeys were immunized with whole inactivated HIV-2 preparations administered with various adjuvants (incomplete Freund s adjuvant, Alum, Ribi, MDP, or Iscoms) and challenged with 10 or 100 MID50 of a homologous monkey-cell grown, cell-free HIV-2. Seven animals were completely protected against i


Mucosal immunization with a live, virulence-attenuated simian immunodeficiency virus (SIV) vaccine elicits antiviral cytotoxic T lymphocytes and antibodies in rhesus macaques.
J Med Primatol. 1994 Feb-May;23(2-3):95-101. Unique Identifier : AIDSLINE MED/95055654
Lohman BL; McChesney MB; Miller CJ; Otsyula M; Berardi CJ; Marthas ML; California Regional Primate Research Center, University of; California, Davis 95616.
An effective AIDS vaccine must protect against sexual transmission of human immunodeficiency virus (HIV). Therefore, vaccine regimens which stimulate antiviral immunity in the genital tract as well as in peripheral blood and systemic lymphoid tissues are needed. Here, we describe a method of immunization by direct ino


Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein.
J Mol Biol. 1994 Nov 25;244(2):198-223. Unique Identifier : AIDSLINE MED/95055757
Massiah MA; Starich MR; Paschall C; Summers MF; Christensen AM; Sundquist WI; Howard Hughes Medical Institute, Baltimore, MD.
The HIV-1 matrix protein forms an icosahedral shell associated with the inner membrane of the mature virus. Genetic analyses have indicated that the protein performs important functions throughout the viral life-cycle, including anchoring the transmembrane envelope protein on the surface of the virus, assisting in vir


Fungal virus capsids, cytoplasmic compartments for the replication of double-stranded RNA, formed as icosahedral shells of asymmetric Gag dimers.
J Mol Biol. 1994 Dec 2;244(3):255-8. Unique Identifier : AIDSLINE MED/95055762
Cheng RH; Caston JR; Wang GJ; Gu F; Smith TJ; Baker TS; Bozarth RF; Trus BL; Cheng N; Wickner RB; et al; Department of Biological Sciences, Purdue University, West; Lafayette, IN 47907-1392.
The primary functions of most virus capsids are to protect the viral genome in the extra-cellular milieu and deliver it to the host. In contrast, the capsids of fungal viruses, like the cores of all other known double stranded RNA viruses, are not involved in host recognition but do shield their genomes, and they also


Cancer incidence in a population with a high prevalence of infection with human immunodeficiency virus type 1.
J Natl Cancer Inst. 1994 Nov 16;86(22):1711-6. Unique Identifier : AIDSLINE MED/95055827
Rabkin CS; Yellin F; Epidemiology Branch, National Cancer Institute, Bethesda, Md; 20892.
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) infection is known to increase the incidence of Kaposi s sarcoma and non-Hodgkin s lymphoma . Parallels with other causes of immunodeficiency suggest a possible effect of HIV-1 on additional cancers. PURPOSE: This study was des


On developing careers in trauma and surgical care: report of the ad hoc committee on careers in trauma surgery, Eastern Association for the Surgery of Trauma [see comments]
J Trauma. 1994 Nov;37(5):700-4. Unique Identifier : AIDSLINE MED/95055895
Shackford SR; Gabram SG; Rozycki GS; Rutherford EJ; Johnson SB; Kauder DA; Miller FB; Trask AL; Booth FV; Zeppa R; University of Vermont, Burlington.
Assessment of an AIDS intervention program during drug abuse treatment.
J Subst Abuse Treat. 1994 Jul-Aug;11(4):367-72. Unique Identifier : AIDSLINE MED/95055938
Boatler JF; Knight K; Simpson DD; Institute of Behavioral Research, Texas Christian University,; Fort Worth 76129.
Since 1985, many drug abuse treatment centers and health care providers have implemented special education programs for individuals who inject drugs. They focus primarily on increasing awareness of the threat of the human immunodeficiency virus (HIV) being spread through drug injection equipment and by sexual activiti


Incorporation of excess wild-type and mutant tRNA(3Lys) into human immunodeficiency virus type 1.
J Virol. 1994 Dec;68(12):7676-83. Unique Identifier : AIDSLINE MED/95055990
Huang Y; Mak J; Cao Q; Li Z; Wainberg MA; Kleiman L; Lady Davis Institute for Medical Research, Jewish General; Hospital, Montreal, Quebec, Canada.
Human immunodeficiency virus (HIV) particles produced in COS-7 cells transfected with HIV type 1 (HIV-1) proviral DNA contain 8 molecules of tRNA(3Lys) per 2 molecules of genomic RNA and 12 molecules of tRNA1,2Lys per 2 molecules of genomic RNA. When COS-7 cells are transfected with a plasmid containing both HIV-1 pro


A naturally occurring single basic amino acid substitution in the V3 region of the human immunodeficiency virus type 1 env protein alters the cellular host range and antigenic structure of the virus.
J Virol. 1994 Dec;68(12):7689-96. Unique Identifier : AIDSLINE MED/95055992
Shioda T; Oka S; Ida S; Nokihara K; Toriyoshi H; Mori S; Takebe Y; Kimura S; Shimada K; Nagai Y; et al; Department of Viral Infection, University of Tokyo, Japan.
Human immunodeficiency virus type 1 circulates in vivo as a mixture of heterologous populations (quasispecies). We previously analyzed the quasispecies of the third hypervariable region (V3) in the viral envelope glycoprotein gp120 in an infected individual and found that the species with a basic amino acid substituti


Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14.
J Virol. 1994 Dec;68(12):7800-9. Unique Identifier : AIDSLINE MED/95056004
Dollard SC; Gummuluru S; Tsang S; Fultz PN; Dewhurst S; Department of Microbiology and Immunology, University of; Rochester Medical Center, New York 14642.
Infection with a variant of simian immunodeficiency virus, SIVsmmPBj14, leads to severe acute disease in macaques. This study was designed to investigate the functional significance of previously described mutations in the viral long terminal repeat (LTR) and to elucidate their contribution to the unique phenotype of


DNA substrate requirements for different activities of the human immunodeficiency virus type 1 integrase protein.
J Virol. 1994 Dec;68(12):7825-32. Unique Identifier : AIDSLINE MED/95056007
van den Ent FM; Vink C; Plasterk RH; Division of Molecular Biology, The Netherlands Cancer Institute,; Amsterdam.
The integrase protein (IN) of human immunodeficiency virus type 1 removes two nucleotides from both 3 ends of the viral DNA (donor cleavage) and subsequently couples the newly generated 3 OH groups to phosphates in the target DNA (integration). The sequence requirements of IN for cleavage as well as for integration


Chinese hamster ovary cells contain transcriptionally active full-length type C proviruses.
J Virol. 1994 Dec;68(12):7840-9. Unique Identifier : AIDSLINE GENBANK/U09104
Lie YS; Penuel EM; Low MA; Nguyen TP; Mangahas JO; Anderson KP; Petropoulos CJ; Molecular Virology Laboratory, Genentech, Inc., South San; Francisco, California 94080.
We have isolated a genomic locus from Chinese hamster ovary (CHO) cells that contains a full-length provirus. Nucleotide sequence analysis indicates that it is a defective member of the rodent type C retrovirus family with an env region that is similar to those of mouse amphotropic retrovirus and subgroup B feline leu


Juxtaposition of two viral DNA ends in a bimolecular disintegration reaction mediated by multimers of human immunodeficiency virus type 1 or murine leukemia virus integrase.
J Virol. 1994 Dec;68(12):7869-78. Unique Identifier : AIDSLINE MED/95056012
Chow SA; Brown PO; Department of Pediatrics, Stanford University Medical Center,; California 94305-5428.
Integration of retroviral DNA involves a coordinated joining of the two ends of a viral DNA molecule into precisely spaced sites on target DNA. In this study, we designed an assay that requires two separate oligonucleotides to be brought together via interactions between integrase promoters to form a crossbones substr


An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences.
J Virol. 1994 Dec;68(12):7879-90. Unique Identifier : AIDSLINE MED/95056013
Vicenzi E; Dimitrov DS; Engelman A; Migone TS; Purcell DF; Leonard J; Englund G; Martin MA; Laboratory of Molecular Microbiology, National Institute of; Allergy and Infectious Diseases, National Cancer Institute,; Bethesda, Maryland 20892.
Nonoverlapping deletions that eliminated the 5 (HIV-1US/603del), middle (HIV-1U5/206del), and 3 (HIV-1U5/604del) thirds of the U5 region of the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) were studied for their effects on virus replication (transient transfection of HeLa cells) and infecti


Epstein-Barr virus intrastrain recombination in oral hairy leukoplakia.
J Virol. 1994 Dec;68(12):7909-17. Unique Identifier : AIDSLINE MED/95056016
Walling DM; Raab-Traub N; Division of Infectious Diseases, University of North Carolina,; Chapel Hill 27599.
In laboratory lymphoblastoid cell lines and in natural human infections, Epstein-Barr virus (EBV) strains have been identified by DNA restriction fragment length polymorphisms of the BamHI H fragment. Multiple, heterogeneous BamHI H fragments have been detected in oral hairy leukoplakia (HLP), raising the question of


The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: strain variation, genetic recombination, and transcriptional expression.
J Virol. 1994 Dec;68(12):7918-26. Unique Identifier : AIDSLINE MED/95056017
Walling DM; Perkins AG; Webster-Cyriaque J; Resnick L; Raab-Traub N; Division of Infectious Diseases, University of North Carolina,; Chapel Hill 27599.
Oral hairy leukoplakia (HLP) lesions frequently contain defective Epstein-Barr virus (EBV) genomes with deletions in the EBNA-2 gene that abundantly replicate and persist within the lesion. To characterize these viral strains and recombinant variants, the EBNA-2 gene in EBV DNA from several different HLP biopsy specim


The activated Mlvi-4 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas encodes an env/Mlvi-4 fusion protein.
J Virol. 1994 Dec;68(12):7927-32. Unique Identifier : AIDSLINE GENBANK/S74213
Patriotis C; Tsichlis PN; Department of Medical Oncology, Fox Chase Cancer Center,; Philadelphia, Pennsylvania 19111.
A genomic DNA probe derived from the region immediately 3 of the clusters of integrated proviruses in the Mlvi-4 locus detects a 5.5-kb mRNA transcript which is specifically expressed in normal rat thymus and spleen. The same probe detects two tumor-specific mRNA transcripts 2.5 and 10 kb long, both of which are expr


Continuous propagation of RRE(-) and Rev(-)RRE(-) human immunodeficiency virus type 1 molecular clones containing a cis-acting element of simian retrovirus type 1 in human peripheral blood lymphocytes.
J Virol. 1994 Dec;68(12):7944-52. Unique Identifier : AIDSLINE GENBANK/S74214
Zolotukhin AS; Valentin A; Pavlakis GN; Felber BK; Human Retrovirus Pathogenesis Group, National Cancer; Institute--Frederick Cancer Research and Development Center,; Maryland 21702-1201.
Molecular clones of human immunodeficiency virus type 1 that contained either 37 point mutations in the Rev-responsive element (RRE) that did not affect the overlapping env reading frame or both a mutated RRE and two mutations that eliminated Rev were constructed. The mutations in the RRE were shown to remove both neg


The p2 domain of human immunodeficiency virus type 1 Gag regulates sequential proteolytic processing and is required to produce fully infectious virions.
J Virol. 1994 Dec;68(12):8017-27. Unique Identifier : AIDSLINE MED/95056028
Pettit SC; Moody MD; Wehbie RS; Kaplan AH; Nantermet PV; Klein CA; Swanstrom R; UNC Lineberger Comprehensive Cancer Center, Chapel Hill.
The proteolytic processing sites of the human immunodeficiency virus type 1 (HIV-1) Gag precursor are cleaved in a sequential manner by the viral protease. We investigated the factors that regulate sequential processing. When full-length Gag protein was digested with recombinant HIV-1 protease in vitro, four of the fi


Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.
J Virol. 1994 Dec;68(12):8035-44. Unique Identifier : AIDSLINE MED/95056030
Munoz E; Courtois G; Veschambre P; Jalinot P; Israel A; Unite de Biologie Moleculaire de l'Expression Genique, Institut; Pasteur, France.
The activity of the NF-kappa B transcription factor is controlled through cytoplasmic retention by either of two types of molecules: the inhibitor I kappa B alpha/MAD3 or the p105 and p100 precursors of the p50 and p52 DNA-binding subunits. Treatment of cells with classical NF-kappa B inducers such as tumor necrosis f


CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection.
J Virol. 1994 Dec;68(12):8056-63. Unique Identifier : AIDSLINE MED/95056032
Matloubian M; Concepcion RJ; Ahmed R; Department of Microbiology and Immunology, University of; California at Los Angeles School of Medicine 90024.
In this study, we have examined the relative contributions of CD4+ and CD8+ T cells in controlling an acute or chronic lymphocytic choriomeningitis virus (LCMV) infection. To study acute infection, we used the LCMV Armstrong strain, which is cleared by adult mice in 8 to 10 days, and to analyze chronic infection, we u


Functional domains of the capsid protein of human immunodeficiency virus type 1.
J Virol. 1994 Dec;68(12):8180-7. Unique Identifier : AIDSLINE MED/95056046
Dorfman T; Bukovsky A; Ohagen A; Hoglund S; Gottlinger HG; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115.
A series of deletions was introduced into the CA domain of the human immunodeficiency virus type 1 Gag polyprotein to examine its role in virus particle and core formation. The mutations resulted in two phenotypes, indicating the existence of two functionally distinct regions within the CA domain. Deletions within a c


Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse.
J Virol. 1994 Dec;68(12):8188-92. Unique Identifier : AIDSLINE MED/95056047
Kaneshima H; Su L; Bonyhadi ML; Connor RI; Ho DD; McCune JM; HIV Group, SyStemix, Inc., Palo Alto, California 94304.
Clinical deterioration in human immunodeficiency virus type 1 (HIV-1) disease is associated with an increased viral burden in the peripheral blood and a loss of circulating CD4+ T cells. HIV-1 isolates obtained prior to this stage of disease often have a slow-low, non-syncytium-inducing (NSI) phenotype, whereas those


Neurovirulent simian immunodeficiency virus replicates productively in endothelial cells of the central nervous system in vivo and in vitro.
J Virol. 1994 Dec;68(12):8202-8. Unique Identifier : AIDSLINE MED/95056049
Mankowski JL; Spelman JP; Ressetar HG; Strandberg JD; Laterra J; Carter DL; Clements JE; Zink MC; Division of Comparative Medicine, Johns Hopkins School of; Medicine, Baltimore, Maryland 21205.
The perivascular location of human immunodeficiency virus-infected cells suggests that the virus enters the central nervous system (CNS) by traversing the blood-brain barrier (BBB). In this study, the simian immunodeficiency virus (SIV) macaque model was used to determine whether SIV infects CNS endothelial cells. SIV


Inhibition of human immunodeficiency virus type 1 in human T cells by a potent Rev response element decoy consisting of the 13-nucleotide minimal Rev-binding domain.
J Virol. 1994 Dec;68(12):8254-64. Unique Identifier : AIDSLINE MED/95056055
Lee SW; Gallardo HF; Gilboa E; Smith C; Program of Molecular Biology, Memorial Sloan-Kettering Cancer; Center, New York, New York 10021.
Intracellular immunization is an anti-viral gene therapy strategy based on the introduction of DNA templates into cells to stably express genetic elements which inhibit viral gene expression and replication. We have recently developed an intracellular immunization strategy for human immunodeficiency virus (HIV) infect


A neutralizing antibody-inducing peptide of the V3 domain of feline immunodeficiency virus envelope glycoprotein does not induce protective immunity.
J Virol. 1994 Dec;68(12):8374-9. Unique Identifier : AIDSLINE MED/95056069
Lombardi S; Garzelli C; Pistello M; Massi C; Matteucci D; Baldinotti F; Cammarota G; da Prato L; Bandecchi P; Tozzini F; et al; Department of Biomedicine, University of Pisa, Italy.
Specific-pathogen-free cats, immunized with a 22-amino-acid synthetic peptide designated V3.3 and derived from the third variable region of the envelope glycoprotein of the Petaluma isolate of feline immunodeficiency virus (FIV), developed high antibody titers to the V3.3 peptide and to purified virus, as assayed by e


Effect of a single amino acid substitution in the V3 domain of the human immunodeficiency virus type 1: generation of revertant viruses to overcome defects in infectivity in specific cell types.
J Virol. 1994 Dec;68(12):8380-5. Unique Identifier : AIDSLINE MED/95056070
Morris JF; Sternberg EJ; Gutshall L; Petteway SR Jr; Ivanoff LA; Department of Molecular Virology and Host Defense, SmithKline; Beecham Pharmaceuticals, King of Prussia, Pennsylvania; 19406-0939.
Proviral clones of human immunodeficiency virus type 1 which contained single amino acid changes in the envelope V3 region were constructed. PCR amplification of Sup-T1 T cells transfected with one such mutant, G312T, revealed low levels of virus that resulted in the generation of a revertant virus, in which an alanin


Isolation of a novel simian T-cell lymphotropic virus from Pan paniscus that is distantly related to the human T-cell leukemia/lymphotropic virus types I and II.
J Virol. 1994 Dec;68(12):8392-5. Unique Identifier : AIDSLINE GENBANK/S74220
Giri A; Markham P; Digilio L; Hurteau G; Gallo RC; Franchini G; Laboratory of Tumor Cell Biology, National Cancer Institute,; Bethesda, Maryland 20892.
An unusual serological profile against human T-cell leukemia/lymphotropic virus type I and II (HTLV-I and -II) proteins was reported in several human Pygmy tribes in Zaire and Cameroon with serum antibodies reactive with gp21 and p24. Here we


Orientation-specific cis complementation by bulge- and loop-mutated human immunodeficiency virus type 1 TAR RNAs.
J Virol. 1994 Dec;68(12):8396-400. Unique Identifier : AIDSLINE MED/95056073
Braddock M; Powell R; Sutton J; Kingsman AJ; Kingsman SM; Department of Biochemistry, University of Oxford, United Kingdom.
Tat activates human immunodeficiency type 1 gene expression by binding to TAR RNA. TAR comprises a partially base paired stem and hexanucleotide loop with a tripyrimidine bulge in the upper stem. In vitro, Tat binds to the bulge and upper stem, with no requirement for the loop. However, in vivo, loop sequences are cri


Integrase mutants of human immunodeficiency virus type 1 with a specific defect in integration.
J Virol. 1994 Dec;68(12):8401-5. Unique Identifier : AIDSLINE MED/95056074
Taddeo B; Haseltine WA; Farnet CM; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts 02115.
A previous genetic analysis of the human immunodeficiency virus type 1 integrase protein failed to identify single amino acid substitutions that only block the integration of viral DNA (C.-G. Shin, B. Taddeo, W.A. Haseltine, and C.M. Farnet, J. Virol. 68:1633-1642, 1994). Additional substitutions of amino acids that a


Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys: evidence for cross-species transmission in the wild.
J Virol. 1994 Dec;68(12):8454-60. Unique Identifier : AIDSLINE GENBANK/U10899
Jin MJ; Rogers J; Phillips-Conroy JE; Allan JS; Desrosiers RC; Shaw GM; Sharp PM; Hahn BH; Department of Medicine, University of Alabama at Birmingham; 35294.
Many African primates are known to be naturally infected with simian immunodeficiency viruses (SIVs), but only a fraction of these viruses has been molecularly characterized. One primate species for which only serological evidence of SIV infection has been reported is the yellow baboon (Papio hamadryas cynocephalus).


Angiocentric lymphoma of the kidney in the acquired immunodeficiency syndrome.
J Urol. 1995 Jan;153(1):137-9. Unique Identifier : AIDSLINE MED/95056204
Thiel R; Sarbia M; Gerharz CD; Ebert T; Schmitz-Drager B; Ackermann R; Department of Urology, Heinrich-Heine-University, Dusseldorf,; Germany.
Angiocentric lymphoma, which is the malignant counterpart of angiocentric immunoproliferative lesions, comprises a rare group of non-Hodgkin s lymphomas of T-cell origin. It is characterized by marked invasion and destruction of small vessels by lymphomatoid cells, predominantly in the lungs. The prognosis is poor and


HIV infection in Thailand: the use of condoms [letter; comment]
JAMA. 1994 Nov 16;272(19):1478-9. Unique Identifier : AIDSLINE MED/95056292
VanLandingham M
December 1, 1994--World AIDS Day [news]
JAMA. 1994 Nov 23-30;272(20):1568. Unique Identifier : AIDSLINE MED/95056320
[An autopsy case of AIDS with hemophilia A who died of DIC and gastrointestinal bleeding associated with gastric carcinoma (signet ring cell carcinoma)]
Rinsho Ketsueki. 1994 Sep;35(9):886-91. Unique Identifier : AIDSLINE MED/95056534
Ishikawa M; Suzuki S; Akutu Y; Toyota T; Nose M; Sakai H; Mori K; Third Department of Internal Medicine, Tohoku University School; of Medicine.
We describe a 39 years-old male hemophilia A patient with acquired immunodeficiency syndrome (AIDS) developing to disseminated intravascular coagulation (DIC) due to gastric carcinoma. He had been diagnosed as human immunodeficiency virus (HIV) sero-positive in 1990. Since then, he has been treated by the oral adminis


A multicenter case-control study of HTLV-I associated uveitis. Study Group for HTLV-I Associated Ocular Diseases.
Jpn J Ophthalmol. 1994;38(2):162-7. Unique Identifier : AIDSLINE MED/95056687
Ohba N; Nakao K; Isashiki Y; Osame M; Sonoda S; Yashiki S; Yamaguchi K; Tajima K; Department of Ophthalmology, Kagoshima University Faculty of; Medicine, Japan.
To elucidate the epidemiology of human T-lymphotropic virus type I (HTLV-I) associated uveitis (HAU), a multicenter case-control study was carried out by the collaboration of university hospitals throughout Kyushu and Okinawa in southwestern Japan where HTLV-I is endemic; two instit


Clinical features of HTLV-I associated uveitis determined in multicenter collaborative study. Study Group for HTLV-I Associated Ocular Diseases.
Jpn J Ophthalmol. 1994;38(2):168-74. Unique Identifier : AIDSLINE MED/95056688
Ohba N; Nakao K; Isashiki Y; Kaminagayoshi T; Sonoda S; Yashiki S; Osame M; Department of Ophthalmology, Kagoshima University Faculty of; Medicine, Japan.
The elucidation of the clinical features of human T-lymphotropic virus type I (HTLV-I) associated uveitis (HAU) was advanced by the results of a multicenter study performed by the collaboration of university hospitals throughout Kyushu and Okinawa and two institutions in the Tokyo-Yokohama metropolitan areas of


HTLV-I seroprevalence in patients with undefined uveitis in central Japan.
Jpn J Ophthalmol. 1994;38(2):175-7. Unique Identifier : AIDSLINE MED/95056689
Goto K; Saeki K; Kurita M; Iijima Y; Miyake A; Ohno S; Division of Ophthalmology, Odawara Municipal Hospital, Japan.
Recently, human T-lymphotropic virus type I (HTLV-I) has been shown to cause endogenous uveitis, HTLV-I associated uveitis. To investigate the association of hereditary or environmental factors with the incidence of this uveitis, HTLV-I seroprevalence was studied in patients with undefined uveitis in central


Establishment of HIV-1-producing cells from peripheral mononuclear cells cultured with normal human serum.
Kitasato Arch Exp Med. 1993 Apr;65 Suppl:37-45. Unique Identifier : AIDSLINE MED/95056876
Kawashima H; Hoshika A; Fukutake K; Fujimaki M; Mizuno F; Iino T; Tsukamoto T; Tada T; Nozaki-Renard J; Department of Pediatrics, Tokyo Medical College, Japan.
Normal human serum (NHS) contributed to the establishment of cells producing HIV-1 under the conditions of coculture of peripheral mononuclear cells (PMC) from HIV-1 seropositive patients and of PHA-prestimulated or -non-stimulated PMC from seronegative healthy donors. No addition of


[Varicella zoster virus infections of the retina in patients with and without immune suppression]
Klin Monatsbl Augenheilkd. 1994 Aug;205(2):103-8. Unique Identifier : AIDSLINE MED/95056901
Helbig H; Bornfeld N; Bechrakis NE; Kellner U; Foerster MH; Universitats-Augenklinik, Klinikum Steglitz, Freie Universitat; Berlin.
BACKGROUND. Infections of the retina with the varicella-zoster virus can lead to severe visual impairment. Patients with immunodeficiency are particularly predisposed to viral infections, and the alterations of the immune system may lead to a modified clinical picture. PATIENTS. Two cases of infections of the retina w


The effect of L-carnitine on the AZT-induced destruction of human myotubes. Part II: Treatment with L-carnitine improves the AZT-induced changes and prevents further destruction.
Lab Invest. 1994 Nov;71(5):773-81. Unique Identifier : AIDSLINE MED/95057042
Semino-Mora MC; Leon-Monzon ME; Dalakas MC; Neuromuscular Diseases Section, National Institutes of; Neurological Diseases and Stroke, National Institutes of Health,; Bethesda, Maryland.
BACKGROUND: Zidovudine ( AZT ) as used in the treatment of AIDS causes a mitochondrial myopathy characterized by enzymatic defects in the respiratory chain system, accumulation of lipid droplets, and carnitine deficiency. Human myotubes treated with AZT


Th1/Th2 cross regulation.
J Theor Biol. 1994 Sep 7;170(1):25-56. Unique Identifier : AIDSLINE MED/95057182
Fishman MA; Perelson AS; Theoretical Biology and Biophysics, Theoretical Division, Los; Alamos National Laboratory, NM 87545.
We present and analyze a model for the cross-regulation of the Th1 and Th2 helper cell subsets during an immune response by the regulatory cytokines interferon-gamma (IFN)-gamma) and interleukin-10 (IL-10). IFN-gamma, secreted by Th1 cells, can inhibit the proliferation of Th2 cells. Interleukin-10, secreted by Th2 ce


A new classification of clinical stages of adult T-cell leukemia based on prognosis of the disease.
Leukemia. 1994 Nov;8(11):1834-7. Unique Identifier : AIDSLINE MED/95057290
Shirono K; Hattori T; Takatsuki K; Division of Clinical Hematology and Immunology, Kumamoto City; Hopital, Japan.
Adult T-cell leukemia (ATL) has been classified into three clinical subtypes: acute, chronic, and smoldering type. However, these clinical subtypes of ATL do not always correlate with prognosis. We propose a new criterion for classification of clinical stages of ATL, based on the expression of Ki-67 antigen in periphe


CD4+ CD8+ granular lymphocytic leukemia arising in a patient with acute myeloblastic leukemia.
Leukemia. 1994 Nov;8(11):1884-9. Unique Identifier : AIDSLINE MED/95057298
Suzushima H; Asou N; Eto K; Nishimura S; Okubo T; Fujimoto T; Yamasaki H; Osato M; Takeya M; Takatsuki K; Second Department of Internal Medicine, Kumamoto University; School of Medicine, Japan.
A 59-year-old woman who had an 8-year history of acute myeloblastic leukemia (AML) developed granular lymphocytic leukemia (GLL). She had a small number of granular lymphocytes (GL) in her bone marrow (BM) at the onset of AML. The GL increased during complete remission (CR) of AML, but not at the relapse. During the t


Children's knowledge and affective response to AIDS.
Matern Child Nurs J. 1994 Apr-Jun;22(2):65-72. Unique Identifier : AIDSLINE MED/95057321
Dear MR; Moore JB; George Mason University, College of Nursing and Health Science,; Fairfax, VA.
Given the urgency of the AIDS crisis, the current emphasis is on prevention of the disease. School-age children may be considered a vulnerable population at risk for future development of HIV infection. Prevention needs to involve educational programs founded on children s knowledge and beliefs about AIDS. Scant liter


Therapy for fungal infections.
Mayo Clin Proc. 1994 Nov;69(11):1111-7. Unique Identifier : AIDSLINE MED/95057336
Sarosi GA; Davies SF; Department of Medicine, Santa Clara Valley Medical Center, San; Jose, California.
In the past, few pharmacologic agents were available for management of fungal disease. After the early introduction of amphotericin B and miconazole, the more recent advent of several new antifungal agents, including ketoconazole, fluconazole, and itraconazole has expanded the options for treatment of fungal infection


[Acute abdomen due to cytomegalovirus in AIDS patients. Apropos 2 cases]
Med Clin (Barc). 1994 Jul 9;103(6):219-21. Unique Identifier : AIDSLINE MED/95057439
Ferre C; Mascaro J; Benasco C; Ramos E; Perez JL; Podzamczer D; Servicio de Enfermedades Infecciosas, Ciutat Sanitaria i; Universitaria de Bellvitge, L'Hospitalet de Llobregat,; Barcelona.
Two cases of acute abdomen--because of acute appendicitis and paralytic ileus--due to cytomegalovirus infection in AIDS patients are reported. In both patients evolution was subacute and cytomegalic inclusions were seen in the histologic examination of the surgical samples. The two


[Bacteremia due to Campylobacter sp. in patients with HIV infection (letter)]
Med Clin (Barc). 1994 Jul 9;103(6):239. Unique Identifier : AIDSLINE MED/95057447
Pigrau C; Almirante B; Bartolome R; Pahissa A
[Unusual forms of bacteremia due to Campylobacter jejuni in patients with HIV infection (letter)]
Med Clin (Barc). 1994 Jul 9;103(6):239. Unique Identifier : AIDSLINE MED/95057448
Knobel H; Lopez-Colomes J; Saballs P; Drobnic L
[Vitiligo associated with the acquired immunodeficiency syndrome (letter)]
Med Clin (Barc). 1994 Sep 24;103(9):358. Unique Identifier : AIDSLINE MED/95057473
Garcia-Patos Briones V; Rodriguez Cano L; Capdevila Morell JA; Costells Rodellas A
[An atrioventricular block secondary to pentamidine treatment (letter)]
Med Clin (Barc). 1994 Sep 24;103(9):359. Unique Identifier : AIDSLINE MED/95057475
Santos Gil I; Jaras Hernandez M
AIDS pathogenesis and prevention [news]
Lancet. 1994 Nov 5;344(8932):1287-8. Unique Identifier : AIDSLINE MED/95057568
Gozlan M
Russia's anti-AIDS law [news]
Lancet. 1994 Nov 5;344(8932):1289-90. Unique Identifier : AIDSLINE MED/95057569
Rich V
Behavioural science in the AIDS epidemic.
Lancet. 1994 Nov 12;344(8933):1312-3. Unique Identifier : AIDSLINE MED/95057603
Watters JK; Institute for Health Policy Studies, School of Medicine,; University of California, San Francisco.
Sensitivity of United States HIV antibody tests for detection of HIV-1 group O infections.
Lancet. 1994 Nov 12;344(8933):1333-4. Unique Identifier : AIDSLINE MED/95057609
Schable C; Zekeng L; Pau CP; Hu D; Kaptue L; Gurtler L; Dondero T; Tsague JM; Schochetman G; Jaffe H; et al; Division of HIV/AIDS, National Centre for Infectious Diseases,; Centers for Disease Control and Prevention, Atlanta, GA 30333.
Infections by highly divergent strains of HIV-1, first detected in central Africa and grouped provisionally as group O, have not been reliably detected by certain European HIV screening tests. Serum specimens from eight probable group O infections from Cameroon were tested by ten


HIV-1 subtype C in Brazil [news]
Lancet. 1994 Nov 12;344(8933):1354. Unique Identifier : AIDSLINE MED/95057615
Csillag C
Learning about HIV-2 [published erratum appears in Lancet 1995 Jan 14;345(8942):136]
Lancet. 1994 Nov 19;344(8934):1380-1. Unique Identifier : AIDSLINE MED/95057656
O'Shaughnessy MV; Schechter MT; British Columbia Centre for Excellence in HIV/AIDS, University of; British Columbia, St. Paul's Hospital, Vancouver, Canada.
Approaches to AIDS vaccines [news]
Lancet. 1994 Nov 19;344(8934):1425. Unique Identifier : AIDSLINE MED/95057670
Rowe PM
Postnatal transmission of HIV-1 through pooled breast milk [letter] [published erratum appears in Lancet 1994 Dec 17;344(8938):1712]
Lancet. 1994 Nov 19;344(8934):1432. Unique Identifier : AIDSLINE MED/95057676
Nduati RW; John GC; Kreiss J
HIV-1 in blister fluid of a patient with toxic epidermal necrolysis and AIDS [letter]
Lancet. 1994 Nov 19;344(8934):1432-3. Unique Identifier : AIDSLINE MED/95057677
Correia O; Delgado L; Santos C; Miranda AM
Association between hepatitis E virus and HIV infection in homosexual men [letter] [see comments]
Lancet. 1994 Nov 19;344(8934):1433. Unique Identifier : AIDSLINE MED/95057678
Montella F; Rezza G; Di Sora F; Pezzotti P; Recchia O
Use of living wills in HIV infection and AIDS [letter] [see comments]
Lancet. 1994 Nov 26;344(8935):1509. Unique Identifier : AIDSLINE MED/95057743
Meadows P
Proton spectroscopy in HIV infection: relaxation times of cerebral metabolites.
Magn Reson Imaging. 1994;12(6):951-7. Unique Identifier : AIDSLINE MED/95057899
Wilkinson ID; Paley M; Chong WK; Sweeney BJ; Shepherd JK; Kendall BE; Hall-Craggs MA; Harrison MJ; Department of Medical Physics and Bioengineering, University; College and Middlesex School of Medicine, London, UK.
In vivo proton spectroscopy has demonstrated abnormalities in the cerebral metabolite ratios from subjects with acquired immunodeficiency syndrome (AIDS). Some of the sequences employed are subject to T1 or T2 weighting, which may affect spectroscopic interpretation. The relaxation times of choline (Cho), creatine (Cr


Medicolegal problems arising from AIDS and health care personnel with special reference to Spanish law.
Med Law. 1994;13(3-4):241-9. Unique Identifier : AIDSLINE MED/95057904
Gallego Riestra S; Martinez Jarreta B; Hinojal Fonseca R; Sanchez Caro J; Catedra de Medicina Legal, Facultad de Medicina, Universidad de; Oviedo, Asturias, Spain.
The ethical and judicial problems that surround the risk of HIV occupational transmission among health care workers are considered. Problems concerning the continued employment of the health providers once they are infected are also taken into account. The relevant Spanish legislation is analysed.


[Diagnosis of major depression in HIV-infected patients]
Minerva Psichiatr. 1994 Sep;35(3):129-38. Unique Identifier : AIDSLINE MED/95058049
Bellini M; Bruschi C; Babini P; Capannini D; Scaramelli AR; Taruschio G; Raise E; Cannella B; De Marco P; Orsini N; et al; Istituto di Psichiatria, Universita degli Studi di Bologna.
A survey of current mood disorders (and especially major depression) is performed after considering quoted literature over the last five years. The sample includes all the HIV-infected-patients continuously referred to the Outpatient Service of the Infectious Diseases dept. of Bologna s Ospedale Maggiore General Hospi


Radioimmune western blotting in comparison with conventional western blotting, second and third generation ELISA assays for the serodiagnosis of HIV-1 infection.
New Microbiol. 1994 Jul;17(3):169-76. Unique Identifier : AIDSLINE MED/95058324
Portincasa P; Conti G; Zannino T; Visalli S; Chezzi C; Istituto di Microbiologia, Facolta di Medicina e Chirurgia,; Universita degli Studi di Parma, Italy.
We compared the performance of second and third generation ELISA assays to detect antibodies to HIV-1 virus with conventional Western blotting (WB) and radioimmune Western blotting (RIWB). Both sera from commercial seroconversion panels and serial dilutions of a serum for HIV-1 antibodies were tested with Murex HIV Re


Modified western blot with recombinant antigens for serological differentiation between HTLV-I and HTLV-II.
New Microbiol. 1994 Jul;17(3):177-85. Unique Identifier : AIDSLINE MED/95058325
Chironna M; Quarto M; Germinario C; Fontana A; Institute of Hygiene-University of Bari, Policlinico, Italy.
Some epidemiological and clinical features of HTLV-I and HTLV-II infections remain unclear due to the inability to confirm and distinguish between the two retroviruses. Since HTLV-I and HTLV-II have a high degree of genomic and aminoacid sequence homology, serologic crossreactions are frequent, making it difficult to


Presence of murine retroviral sequences in human cell line transplanted in immunosuppressed SCID-mice.
New Microbiol. 1994 Jul;17(3):195-202. Unique Identifier : AIDSLINE MED/95058327
Cavallo R; Valente G; Jemma C; Gribaudo G; Landolfo S; Cavallo G; Institute of Microbiology, University of Torino, Italy.
The SCID-hu mouse, a severe combined immunodeficient mouse transplanted with human hematopoietic cells, has been proposed as an experimental model for HIV-1 infection. However, like other animal models for infectious diseases, the SCID-hu mouse should provide the replication of the experimental agent without conferrin


Rapid detection of mycobacteria by combining a radiometric detection system with DNA probes.
New Microbiol. 1994 Jul;17(3):249-53. Unique Identifier : AIDSLINE MED/95058334
Mascellino MT; Rossi F; Iegri F; Iona E; Institute of Infectious Diseases, La Sapienza University, Rome,; Italy.
Forty-four Mycobacterium-spp. were isolated in 33 patients from an infectious diseases ward. All patients were HIV-positive and most of them were drug-abusers. M. avium-intracellulare was the most common type of MOTT (Mycobacteria other than tuberculosis) detected and the only microorganism isolated in patients with m


Human T cell leukemia virus type 1 (HTLV-1) antibodies in healthy populations and renal transplanted patients in the north-east of Brazil.
Microbiol Immunol. 1994;38(6):475-8. Unique Identifier : AIDSLINE MED/95058368
Linhares MI; Eizuru Y; de Andrade GP; Fonseca IB; Carvalho Junior LB; Moreira IT; Minamishima Y; Laboratorio de Imunopatologia Keizo Asami, Setor de Virologia,; Universidade Federal de Pernambuco, Recife, Brazil.
The seroprevalence of human T cell leukemia virus type 1 (HTLV-1) infection was investigated in Brazilians (570): native inhabitants (298) and descendants from Japanese (272) living in Recife and its neighborhoods--North-east of Brazil. Furthermore, polytransfused renal transplanted patients (54) were also examined fo


Disseminated cutaneous nocardiosis as a presenting illness of HIV infection.
Med J Aust. 1994 Nov 21;161(10):609-11. Unique Identifier : AIDSLINE MED/95058422
Patel A; Heath TC; Bowden FJ; Fisher DA; Currie BJ; AIDS/STD Unit, Northern Territory Department of Health and; Community Services, Darwin, NT.
Heterosexual transmission of HIV [letter; comment]
Med J Aust. 1994 Nov 7;161(9):573-4. Unique Identifier : AIDSLINE MED/95058467
Dinnen AH
Gay teens not avoiding risk [news]
Minn Med. 1994 Sep;77(9):52. Unique Identifier : AIDSLINE MED/95058661
Ophthalmology quiz #9. Acquired immunodeficiency syndrome (AIDS).
Mo Med. 1994 Oct;91(10):619-20. Unique Identifier : AIDSLINE MED/95058694
Hagan JC 3rd; Midwest Eye Institute of Kansas City, Inc., Missouri.
Update: trends in AIDS diagnosis and reporting under the expanded surveillance definition for adolescents and adults--United States, 1993.
MMWR Morb Mortal Wkly Rep. 1994 Nov 18;43(45):826-31. Unique Identifier : AIDSLINE MED/95058704
The expansion of the surveillance case definition for acquired immunodeficiency syndrome (AIDS) in January 1993 (1) resulted in a large increase in reported AIDS cases. This increase has primarily reflected reports of human immunodeficiency virus (HIV)-infected persons in whom severe immunosuppression (CD4+ count


Sexual behaviors and drug use among youth in dropout-prevention programs--Miami, 1994.
MMWR Morb Mortal Wkly Rep. 1994 Dec 2;43(47):873-6. Unique Identifier : AIDSLINE MED/95058712
Youth who have dropped out of school have higher frequencies than youth who remain in school of behaviors that increase risk for sexually transmitted diseases (STDs) and human immunodeficiency virus (HIV) infection (1). Youth identified as potential dropouts may be likely to take increased risks, but their STD/HIV ris


Anti-human immunodeficiency virus type 1 activity of hydroxyurea in combination with 2',3'-dideoxynucleosides.
Mol Pharmacol. 1994 Oct;46(4):767-72. Unique Identifier : AIDSLINE MED/95058946
Gao WY; Johns DG; Mitsuya H; Experimental Retrovirology Section, National Cancer Institute,; Bethesda, Maryland 20892.
The effects of hydroxyurea (HU), an inhibitor of ribonucleotide reductase, on the replication of human immunodeficiency virus type 1 (HIV-1) in activated peripheral blood mononuclear cells were studied. The inhibition of HIV-1 replication by HU alone was dose dependent, with a 90% inhibitory concentration of 0.4 mM, a


Enhancement by 2'-deoxycoformycin of the 5'-phosphorylation and anti-human immunodeficiency virus activity of 2',3'-dideoxyadenosine and 2'-beta-fluoro-2',3'-dideoxyadenosine.
Mol Pharmacol. 1994 Nov;46(5):1002-8. Unique Identifier : AIDSLINE MED/95058950
Ahluwalia GS; Cooney DA; Shirasaka T; Mitsuya H; Driscoll JS; Johns DG; Laboratory of Medicinal Chemistry, National Cancer Institute,; National Institutes of Health, Bethesda, Maryland 20892.
The anti-human immunodeficiency virus agents 2 ,3 -dideoxyadenosine (ddAdo) and 2 -beta-fluoro-2 ,3 -dideoxyadenosine (2 -beta-F-ddAdo) are rapidly converted, both in vitro and in vivo, to the corresponding inosine analogs by the widely distributed enzyme adenosine deaminase (EC 3.5.4.4). We have determined the effect


Minimal requirements for peptide mediated activation of CD8+ CTL.
Mol Immunol. 1994 Nov;31(16):1285-93. Unique Identifier : AIDSLINE MED/95059086
Brower RC; England R; Takeshita T; Kozlowski S; Margulies DH; Berzofsky JA; Delisi C; Department of Electrical, Computer and Systems Engineering,; Boston University, MA 02215.
A physical chemical model of T cell stimulation by class I-peptide complexes was developed and used to analyse in vitro studies of gamma-interferon release as a function of the number of peptide and MHC molecules. The analysis provided reasonable estimates of well identified parameters, including equilibrium constants


Competitive polymerase chain reaction for quantitating feline immunodeficiency virus load in infected cat tissues.
Mol Cell Probes. 1994 Jun;8(3):229-34. Unique Identifier : AIDSLINE MED/95059094
Pistello M; Menzo S; Giorgi M; Da Prato L; Cammarota G; Clementi M; Bendinelli M; Department of Biomedicine, University of Pisa, Italy.
To quantitate FIV provirus copy numbers present in tissue of infected cats, we have applied a competitive polymerase chain reaction (cPCR) recently described for HIV. The method consists in coamplifying a fixed amount of the DNA to be examined with graded copy numbers of a DNA competitor incorporating a short deletion


Detection of HIV-1 DNA by polymerase chain reaction incorporation of digoxigenin-11-dUTP and hybridization to immobilized probes.
Mol Cell Probes. 1994 Jun;8(3):235-40. Unique Identifier : AIDSLINE MED/95059095
Taveira NC; Gomes PC; Ferreira MO; Pereira JM; Faculdade de Farmacia da Universidade de Lisboa, Departamento de; Microbiologia, Portugal.
We have developed a new non-isotopic polymerase chain reaction (PCR) based method for the detection of the human immunodeficiency virus type 1 (HIV-1) DNA in clinical samples. In this method a two step PCR is used to amplify and label HIV-1 DNA segments by incorporation of digoxigenin-11-dUTP (dig-dUTP). Digoxigenin l


Two-stage tuberculin skin testing in an HIV-infected population: a preliminary report.
Mt Sinai J Med. 1994 Sep;61(4):337-40. Unique Identifier : AIDSLINE MED/95059127
Goldstein S; Perlman DC; Salomon N; Division of Chemical Dependency and Infectious Diseases, Beth; Israel Medical Center, New York, NY 10003.
To identify differences in purified protein derivative (PPD) tuberculin positivity rates and to assess the utility of sequential PPD testing among persons with HIV infection, we performed two sequential administrations of 5 tuberculin units of PPD in a group of persons with HIV infection. Eligible patients were skin-t


Drug-resistant tuberculosis: factors associated with rise in resistance in an HIV-infected urban population.
Mt Sinai J Med. 1994 Sep;61(4):341-8. Unique Identifier : AIDSLINE MED/95059128
Salomon N; Perlman DC; DePalo VA; Kolokathis A; Wilets I; Department of Medicine, Beth Israel Medical Center, New York, NY; 10003.
Our objective was to characterize the population with tuberculosis (TB) and to identify factors predictive of resistance to anti-TB agents in an area of high prevalence of human immunodeficiency virus infection. We reviewed microbiology and clinical records from 1988 to 1991 at Beth Israel Medical Center, New York Cit


Epidural abscess in the cervical spine.
Mt Sinai J Med. 1994 Sep;61(4):357-62. Unique Identifier : AIDSLINE MED/95059130
Rigamonti D; Liem L; Wolf AL; Fiandaca MS; Numaguchi Y; Hsu FP; Nussbaum ES; Department of Neurosurgery, Johns Hopkins University, Baltimore,; MD 21287.
A ten-year retrospective review of 23 cases of documented spinal epidural abscess in the cervical spine was undertaken to define the clinical features and establish current diagnostic and therapeutic criteria. Diagnosis was made by magnetic resonance imaging or myelography. Risk factors included intravenous drug abuse


Selective tuberculin anergy: case report and review.
Mt Sinai J Med. 1994 Sep;61(4):363-5. Unique Identifier : AIDSLINE MED/95059131
Montecalvo MA; Wormser GP; Department of Medicine, New York Medical College, Valhalla.
Because of the human immunodeficiency virus epidemic, skin testing for Mycobacterium tuberculosis is now performed in conjunction with control skin tests to assess anergy and thus provide information to aid in the interpretation of a negative tuberculin test. However, anergy can occur selectively to purified protein d


Intersecting epidemics--crack cocaine use and HIV infection among inner-city young adults. Multicenter Crack Cocaine and HIV Infection Study Team [see comments]
N Engl J Med. 1994 Nov 24;331(21):1422-7. Unique Identifier : AIDSLINE MED/95059231
Edlin BR; Irwin KL; Faruque S; McCoy CB; Word C; Serrano Y; Inciardi JA; Bowser BP; Schilling RF; Holmberg SD; Division of HIV/AIDS, Centers for Disease Control and Prevention,; Atlanta, GA 30333.
BACKGROUND AND METHODS. The smoking of crack cocaine is thought to be associated with high-risk sexual practices that accelerate the spread of infection with the human immunodeficiency virus (HIV). We studied 2323 young adults, 18 to 29 years of age, who smoked crack regularly or who had never smoked crack. The study


Targeted HIV-prevention programs.
N Engl J Med. 1994 Nov 24;331(21):1451-3. Unique Identifier : AIDSLINE MED/95059237
Des Jarlais DC; Padian NS; Winkelstein W Jr; Beth Israel Medical Center, New York, NY 10013.
An effective program to prevent HIV infection must have both universal and targeted components. The universal component includes reducing HIV-related discrimination, removing commercial restrictions on the materials necessary for safer behavior, and providing information about the risk of HIV. The targeted component i


The response of symptomatic neurosyphilis to high-dose intravenous penicillin G in patients with human immunodeficiency virus infection [see comments]
N Engl J Med. 1994 Dec 1;331(22):1469-73. Unique Identifier : AIDSLINE MED/95059250
Gordon SM; Eaton ME; George R; Larsen S; Lukehart SA; Kuypers J; Marra CM; Thompson S; Department of Medicine, Grady Memorial Hospital, Emory University; School of Medicine, Atlanta.
BACKGROUND. Infection with the human immunodeficiency virus (HIV) may affect both the natural course of syphilis and the response to treatment. We examined the response to treatment with high-dose penicillin G in HIV-infected patients with symptomatic neurosyphilis. METHODS. Neuro


Brief report: cerebral syphilitic gumma confirmed by the polymerase chain reaction in a man with human immunodeficiency virus infection [see comments]
N Engl J Med. 1994 Dec 1;331(22):1488-91. Unique Identifier : AIDSLINE MED/95059253
Horowitz HW; Valsamis MP; Wicher V; Abbruscato F; Larsen SA; Wormser GP; Wicher K; Department of Medicine, New York Medical College, Valhalla, NY.
Neurosyphilis in HIV-infected persons [editorial; comment]
N Engl J Med. 1994 Dec 1;331(22):1516-7. Unique Identifier : AIDSLINE MED/95059259
Musher DM; Baughn RE
Heterosexual transmission of HIV [letter; comment]
N Engl J Med. 1994 Dec 22;331(25):1717-8; discussion 1718-9. Unique Identifier : AIDSLINE MED/95059339
Ambati J; Ambati BK; Rao AM
Heterosexual transmission of HIV [letter; comment]
N Engl J Med. 1994 Dec 22;331(25):1718; discussion 1718-9. Unique Identifier : AIDSLINE MED/95059340
Brody S
Heterosexual transmission of HIV [letter; comment]
N Engl J Med. 1994 Dec 22;331(25):1718; discussion 1718-9. Unique Identifier : AIDSLINE MED/95059341
Morrison E
Heterosexual transmission of HIV [letter; comment]
N Engl J Med. 1994 Dec 22;331(25):1718; discussion 1718-9. Unique Identifier : AIDSLINE MED/95059342
Padian NS; Vittinghoff E; Shiboski S
AIDS 'czar' favours basic research [news]
Nature. 1994 Nov 17;372(6503):211. Unique Identifier : AIDSLINE MED/95059438
Macilwain C
Hopes and doubts greet Paris AIDS 'summit' [news]
Nature. 1994 Nov 24;372(6504):308. Unique Identifier : AIDSLINE MED/95059460
Butler D
The WHO and why of HIV vaccine trials [comment]
Nature. 1994 Nov 24;372(6504):313-4. Unique Identifier : AIDSLINE MED/95059464
Moore J; Anderson R; Aaron Diamond AIDS Research Center, New York, New York 10016.
A World Health Organization (WHO) advisory committee meeting in Geneva at the end of last month approved phase III trials for HIV vaccines in developing countries. What is the justification for this decision?


Specific incorporation of cyclophilin A into HIV-1 virions [see comments]
Nature. 1994 Nov 24;372(6504):359-62. Unique Identifier : AIDSLINE MED/95059477
Franke EK; Yuan HE; Luban J; Department of Medicine, Columbia University, College of; Physicians and Surgeons, New York, New York 10032.
Little is known about host factors necessary for retroviral virion assembly or uncoating. We have previously shown that the principal structural protein of the human immunodeficiency virus HIV-1, the Gag polyprotein, binds the cyclophilin peptidyl-prolyl isomerases; cyclophilins catalyse a rate-limiting step in protei


Functional association of cyclophilin A with HIV-1 virions [see comments]
Nature. 1994 Nov 24;372(6504):363-5. Unique Identifier : AIDSLINE MED/95059478
Thali M; Bukovsky A; Kondo E; Rosenwirth B; Walsh CT; Sodroski J; Gottlinger HG; Division of Human Retrovirology, Dana-Farber Cancer Institute,; Boston, Massachusetts.
Cyclophilins are a family of proteins that bind the immunosuppressant cyclosporin A, possess peptidyl-prolyl cis-trans isomerase activity, and assist in the folding of proteins. Human cyclophilins A and B are host cell proteins that bind specifically to the HIV-1 Gag polyprotein p55gag in vitro. Here we report that vi


The economic impact of AIDS: a challenge for nursing.
Nurs Econ. 1994 Sep-Oct;12(5):266-71, 286. Unique Identifier : AIDSLINE MED/95059551
Peri TA
Estimates to determine the cost of financing AIDS care have been uncertain. Current policies governing private insurance as well as Medicaid/Medicare eligibility have created a number of barriers for people with AIDS (PWA). As the number of AIDS cases increase, nursing will play a crucial role in developing necessary


[Exogenous reinfection with Mycobacterium tuberculosis caused by nosocomial transmission by a patient with AIDS]
Ned Tijdschr Geneeskd. 1994 Oct 22;138(43):2152-4. Unique Identifier : AIDSLINE MED/95059572
van Deutekom H; Claessen FA; Koeleman JG; de Haas PE; Gemeentelijke Geneeskundige en Gezondheidsdienst, afd.; Tuberculosebestrijding, Amsterdam.
A 55-year-old AIDS patient relapsed with tuberculosis as a result of exogenous reinfection, 1.5 years after a prior diagnosis of tuberculosis, for which he had been treated. He was reinfected after exposure to another AIDS patient, a 25-year-old man with tuberculosis, when they were hospitalized together during 5 days


[Sexually transmissible diseases, HIV and AIDS in migrants]
Ned Tijdschr Geneeskd. 1994 Oct 29;138(44):2188-92. Unique Identifier : AIDSLINE MED/95059583
van den Hoek JA; Coutinho RA; Gemeentelijke Geneeskundige en Gezondheidsdienst, Amsterdam.
[The role of superantigens in infections]
Ned Tijdschr Geneeskd. 1994 Nov 5;138(45):2235-8. Unique Identifier : AIDSLINE MED/95059593
Groeneveld PH; Academisch Ziekenhuis, afd. Infectieziekten, Leiden.
Symmetrical external capsule lesions in a patient with herpes simplex encephalitis.
Neuropediatrics. 1994 Jun;25(3):162-4. Unique Identifier : AIDSLINE MED/95059818
Kimura S; Nezu A; Osaka H; Saito K; Department of Pediatrics, Urafune Hospital of Yokohama City; University, Japan.
A 7-year-old boy had symmetrical transient high signal lesions in the external capsules on T2-weighted image during the recovery phase of herpes simplex virus (HSV) encephalitis. Although this finding has never been reported in HSV or other viral encephalitis, a postinfectious allergic mechanism is suspected in this p


Clinicopathologic correlations of HIV-1-associated vacuolar myelopathy: an autopsy-based case-control study.
Neurology. 1994 Nov;44(11):2159-64. Unique Identifier : AIDSLINE MED/95060009
Dal Pan GJ; Glass JD; McArthur JC; Department of Neurology, Johns Hopkins University, Baltimore, MD.
To determine the clinical correlates of HIV-1-associated vacuolar myelopathy (VM), we designed a case-control study based on 215 AIDS autopsies in which we examined the spinal cord. We defined a case as an individual dying with AIDS and with VM present at autopsy; we defined a control as an individual dying with AIDS


Cytomegalovirus multifocal neuropathy in AIDS: analysis of 15 consecutive cases.
Neurology. 1994 Nov;44(11):2174-82. Unique Identifier : AIDSLINE MED/95060011
Roullet E; Assuerus V; Gozlan J; Ropert A; Said G; Baudrimont M; el Amrani M; Jacomet C; Duvivier C; Gonzales-Canali G; et al; Department of Neurology, Hopital Saint-Antoine, France.
A severe multifocal neuropathy caused by cytomegalovirus (CMV-MN) can occur in the late stage of human immunodeficiency virus (HIV) infection. In a retrospective study, we identified 15 consecutive HIV-positive patients with a diagnosis of CMV-MN based on (1) markedly asymmetric ne


Speech motor control disorder after HIV infection [see comments]
Neurology. 1994 Nov;44(11):2187-9. Unique Identifier : AIDSLINE MED/95060014
Lopez OL; Becker JT; Dew MA; Banks G; Dorst SK; McNeil M; Department of Neurology, School of Medicine, University of; Pittsburgh, PA.
We examined the clinical characteristics of six right-handed patients who developed speech motor control disorders after human immunodeficiency virus (HIV) infection. They exhibited an ataxic dysarthria, characterized by irregular articulatory breakdowns in consonant and vowel timing; were slow in timed decision-makin


HIV dementia [letter; comment]
Neurology. 1994 Nov;44(11):2214. Unique Identifier : AIDSLINE MED/95060029
Brew BJ
Zinc supplementation and cellular and humoral immune function in chronic haemodialysis patients [letter; comment]
Nephrol Dial Transplant. 1994;9(6):736-7. Unique Identifier : AIDSLINE MED/95060146
Brodersen HP; Holtkamp W; Larbig D
Intracerebral injection of human immunodeficiency virus type 1 coat glycoprotein GP120 does not produce neurodegeneration in rats.
Neurosci Lett. 1994 Jul 18;176(1):97-100. Unique Identifier : AIDSLINE MED/95060316
Bagetta G; Finazzi-Agro A; Palma E; Nistico G; Faculty of Pharmacy, Calabria University, Cosenza, Italy.
The human immunodeficiency virus type 1 (HIV-1) coat glycoprotein, GP120 has been reported to cause death of several neuronal cell types maintained in vitro. In the present experiments the gross behavioural, electrocortical (ECoG) and neuropathological effects of GP120 were studied in rats chronically microinfused int


AZT and perinatal transmission--the real scoop for health care professionals.
Nurs Health Care. 1994 Oct;15(8):398-9. Unique Identifier : AIDSLINE MED/95060345
Meredith L
Idiopathic CD4+ lymphocytopenia in New Jersey.
N J Med. 1994 Sep;91(9):604-6. Unique Identifier : AIDSLINE MED/95060354
Laraque F; Sosin D; Division of AIDS Prevention and Control, DOH, Trenton, NJ 08625.
Ten persons with idiopathic CD4+ lymphocytopenia (ICL) were reported in 1992. No common clinical or epidemiologic characteristics or evidence of HIV infection were found. It is unclear whether ICL is a syndrome of undetermined etiology or an immunologic manifestation of various diseases.


Discontinuation of total parenteral nutrition in a patient with acquired immunodeficiency syndrome: a Canadian perspective.
Nutr Rev. 1994 Aug;52(8 Pt 1):271-4. Unique Identifier : AIDSLINE MED/95060360
Knowles JB; Gilmore N; Nutrition Support Service, Deaconess Hospital, Evansville, IN.
Provision of nourishment to terminally ill patients has been a controversial topic in clinical medicine. Determination of the limits of palliative care requires an understanding of the disease process, as well as the boundaries of patient self-determination. With the advent of living wills, the determination of the pa


Maternal vitamin A deficiency is associated with increased mother-to-child transmission of the human immunodeficiency virus (HIV).
Nutr Rev. 1994 Aug;52(8 Pt 1):281-2. Unique Identifier : AIDSLINE MED/95060363
Children generally acquire human immunodeficiency virus (HIV) infection through mother-to-child transmission. Currently, an estimated 1 million children are infected with HIV. A recent study in Malawi has shown that vitamin A status is an important risk factor for mother-to-child t


Antiretroviral therapy [news]
Nurse Pract. 1994 Aug;19(8):12-4. Unique Identifier : AIDSLINE MED/95060381
Klaus BD
Providing primary care to the HIV-at-risk and infected child.
Nurse Pract. 1994 Aug;19(8):48-52. Unique Identifier : AIDSLINE MED/95060389
Kellinger KG; Pediatric AIDS Program, University of Maryland at Baltimore.
Pediatric HIV disease is a growing epidemic in the United States . As the incidence of pediatric HIV disease increases, so will the need for primary care providers knowledgeable in pediatric HIV disease. Primary care providers must have the knowledge and expertise to identify those infa


AIDS knowledge and condom use in a birth cohort of 16 year olds.
N Z Med J. 1994 Nov 23;107(990):480-3. Unique Identifier : AIDSLINE MED/95060436
Fergusson DM; Lynskey MT; Horwood LJ; Christchurch Health and Development Study, Christchurch School of; Medicine.
AIMS. The aims of this study were to examine levels of AIDS knowledge and contraceptive practices in a birth cohort of 16 year old Christchurch born children. METHODS. The study was based on the birth cohort of young people participating in the Christchurch Health and Development Study. At age 16 years 953 subjects we


Maternal transmission of human immunodeficiency virus-1.
Obstet Gynecol Surv. 1994 Aug;49(8):577-84. Unique Identifier : AIDSLINE MED/95060524
Paz I; Seidman DS; Mashiach S; Stevenson DK; Department of Pediatrics, Stanford University School of Medicine,; California.
The dramatic increase in the number of women of childbearing age infected with human immunodeficiency virus (HIV) has led to the revelation of another terrible consequence of the human immunodeficiency virus (HIV) pandemic; maternal transmission of HIV to the fetus. Over 90 per cent of the children who are infected wi


Cytologic-histologic discrepancy in human immunodeficiency virus-positive women referred to a colposcopy clinic.
Obstet Gynecol. 1994 Dec;84(6):1016-20. Unique Identifier : AIDSLINE MED/95060529
Boardman LA; Peipert JF; Cooper AS; Cu-Uvin S; Flanigan T; Raphael SI; Department of Obstetrics and Gynecology, Women and Infants'; Hospital, Providence, Rhode Island.
OBJECTIVE: To evaluate the rate of discrepancy between cytology and histology in a referral-based population of human immunodeficiency virus (HIV)-positive women compared to HIV-negative women and women whose HIV status was unknown. METHODS: From January 1, 1990 to December 31, 1993, approximately 830 women underwent


Blood transfusion for radical hysterectomy before and after the discovery of transfusion-related human immunodeficiency virus infection.
Obstet Gynecol. 1994 Dec;84(6):974-8. Unique Identifier : AIDSLINE MED/95060556
Benjamin I; Barakat RR; Curtin JP; Jones WB; Lewis JL Jr; Hoskins WJ; Department of Surgery, Memorial Sloan-Kettering Cancer Center,; New York, New York.
OBJECTIVE: To compare the patterns of perioperative blood transfusion in patients undergoing radical hysterectomy in time periods before and after the discovery of transfusion-related human immunodeficiency virus (HIV) infection. METHODS: We reviewed the medical records of all patients who underwent radical hysterecto


Randomized trials of megestrol acetate for AIDS-associated anorexia and cachexia.
Oncology. 1994 Oct;51 Suppl 1:19-24. Unique Identifier : AIDSLINE MED/95060581
Von Roenn JH; Department of Internal Medicine, Northwestern University,; Chicago, IL 60611.
Involuntary weight loss is a frequent complication of acquired immune deficiency syndrome (AIDS) and ultimately affects the majority of patients. The deleterious effects of weight loss on immune function and the physical and psychological sequelae of severe weight loss are well recognized. Megestrol acetate induces ap


Oral histoplasmosis in HIV-infected patients [letter; comment]
Oral Surg Oral Med Oral Pathol. 1994 Sep;78(3):277-8. Unique Identifier : AIDSLINE MED/95060676
Cohen PR
Percutaneous and mucous membrane exposure protocol in a southeastern dental school.
Oral Surg Oral Med Oral Pathol. 1994 Sep;78(3):401-7. Unique Identifier : AIDSLINE MED/95060698
Stewart CM; Jones AC; Bates RE; Boeff D; Migliorati C; Bentrup K; Department of Oral Diagnostic Sciences, University of Florida,; College of Dentistry, Gainesville.
A southeastern dental educational institution formalized a Percutaneous and Mucous Membrane Exposure Protocol in 1990. This article outlines the development, implementation, and administration of the protocol including risk assessment and rationale for testing health care workers and source persons. Pretest and postte


A cellular protein which is coprecipitated with HTLV-I rex protein in the presence of the target mRNA.
Oncogene. 1994 Dec;9(12):3535-44. Unique Identifier : AIDSLINE MED/95060811
Katahira J; Siomi H; Ishizaki T; Umemoto T; Tanaka Y; Shida H; Institute for Virus Research, Kyoto University, Japan.
We examined the cellular protein(s) which can associate with Rex protein of human T cell leukemia virus type I (HTLV-I), using Rex-maltose binding protein (MBP) fusion protein. Immunoprecipitation of RexMBP with anti-MBP antibody revealed that a 24 kD protein (p24) associated with RexMBP only in the presence of Rex-re


[A report from the XVth World Congress of Otolaryngology, Head and Neck Surgery , Istambul]
Otolaryngol Pol. 1994;48(1):104-9. Unique Identifier : AIDSLINE MED/95060856
Pietruski J
Kaposi's sarcoma of the head and neck in patients with acquired immunodeficiency syndrome.
Otolaryngol Head Neck Surg. 1994 Nov;111(5):618-24. Unique Identifier : AIDSLINE MED/95060903
Singh B; Har-el G; Lucente FE; Department of Otolaryngology, State University of New York Health; Science Center at Brooklyn.
Kaposi s sarcoma is the most common neoplastic process in patients infected with the human immunodeficiency virus. Moreover, the occurrence of Kaposi s sarcoma in human immunodeficiency virus-infected patients advances their classification to having the acquired immunodeficiency syndrome. We reviewed the medical recor


PNA statement in opposition to routine testing of health care workers for human immunodeficiency virus antibody.
Pa Nurse. 1994 Oct;49(10):7. Unique Identifier : AIDSLINE MED/95060935
The effects of parallel bars, body weight support and speed on the modulation of the locomotor pattern of spastic paretic gait. A preliminary communication.
Paraplegia. 1994 Aug;32(8):540-53. Unique Identifier : AIDSLINE MED/95060964
Visintin M; Barbeau H; School of Physical and Occupational Therapy, McGill University,; Montreal, Quebec, Canada.
The effects of walking with and without parallel bars, providing 40% body weight support (BWS) and increasing speed on the gait pattern of spastic paretic subjects during treadmill locomotion were investigated. In asymmetrically involved subjects, walking without parallel bars led to a more symmetrical gait pattern wi


Mechanisms of innate and acquired resistance to Cryptosporidium parvum infection in SCID mice.
Parasite Immunol. 1994 Jun;16(6):315-20. Unique Identifier : AIDSLINE MED/95060974
McDonald V; Bancroft GJ; London School of Hygiene and Tropical Medicine, Department of; Clinical Sciences, UK.
SCID mice, which lack T and B cells, were used as hosts to investigate the nature of both T cell-independent and T-cell-dependent immune responses to infection with Cryptosporidium parvum. We found previously that SCID mice developed chronic infections in which the level of oocyst excretion was low up to about eight w


The role of CD4 cells in protective immunity to Brugia pahangi.
Parasite Immunol. 1994 Jul;16(7):385-7. Unique Identifier : AIDSLINE MED/95060984
Bancroft AJ; Grencis RK; Else KJ; Devaney E; Liverpool School of Tropical Medicine, UK.
The BALB/c mouse immunized sub-cutaneously (s.c.) with 45 kRad attenuated third stage larvae (L3) of the lymphatic filarial nematode Brugia pahangi is strongly immune to a challenge infection (75-100% reduction in recovery at day six post challenge). Analysis of spleen cell supernatants from immunized mice re-stimulat


Septata intestinalis frequently isolated from stool of AIDS patients with a new cultivation method.
Parasitology. 1994 Sep;109 ( Pt 3):281-9. Unique Identifier : AIDSLINE MED/95060992
van Gool T; Canning EU; Gilis H; van den Bergh Weerman MA; Eeftinck Schattenkerk JK; Dankert J; Department of Medical Microbiology, University of Amsterdam, The; Netherlands.
Two species of microsporidia, Enterocytozoon bieneusi and Septata intestinalis have been reported as intestinal parasites of AIDS patients. In attempts to establish E. bieneusi in vitro, spores were concentrated from stool samples from 4 AIDS patients with biopsy-proven E. bieneusi infections. After sterilization of t


Improved outcome for young children with AIDS, Pneumocystis carinii pneumonia, and acute respiratory failure.
Pediatr Pulmonol. 1994 Aug;18(2):114-8. Unique Identifier : AIDSLINE MED/95061027
Wong HR; Chundu KR; Division of Pediatric Medicine, Children's National Medical; Center, Washington, District of Columbia.
OBJECTIVE: To describe the clinical course of children with acquired immunodeficiency syndrome, requiring mechanical ventilation secondary to Pneumocystis carinii pneumonia, with respect to intensive care unit outcome, long-term survival after intensive care unit discharge, and possible predictors of outcome. DESIGN:


Human immunodeficiency virus type 1 IgA antibody in breast milk and serum.
Pediatr Infect Dis J. 1994 Jul;13(7):603-8. Unique Identifier : AIDSLINE MED/95061060
Duprat C; Mohammed Z; Datta P; Stackiw W; Ndinya-Achola JO; Kreiss JK; Holmes KK; Plummer FA; Embree JE; Department of Medical Microbiology, University of Manitoba,; Winnipeg, Canada.
Breast-feeding plays a potentially significant role in mother to child transmission of human immunodeficiency virus type 1 (HIV-1). The additional transmission risk attributable to breast-feeding and the factors that enhance or inhibit transmission are presently unknown. One mechanism by which breast milk might inhibi


Virus-induced neutrophil dysfunction: role in the pathogenesis of bacterial infections.
Pediatr Infect Dis J. 1994 Jul;13(7):643-52. Unique Identifier : AIDSLINE MED/95061068
Abramson JS; Wheeler JG; Department of Pediatrics, Bowman Gray School of Medicine of Wake; Forest University, Winston-Salem, NC 27157.
Evaluation of prophylaxis against invasive pneumococcal infections in human immunodeficiency virus-infected children [published erratum appears in Pediatr Infect Dis J 1994 Nov;13(11):958]
Pediatr Infect Dis J. 1994 Jul;13(7):667-9. Unique Identifier : AIDSLINE MED/95061077
Peters VB; Hyatt AC; Schechter C; Diamant EP; Hodes DS; Department of Pediatrics, Mount Sinai School of Medicine, New; York, NY.
Canadian street youth: correlates of sexual risk-taking activity.
Pediatr Infect Dis J. 1994 Aug;13(8):690-7. Unique Identifier : AIDSLINE MED/95061082
MacDonald NE; Fisher WA; Wells GA; Doherty JA; Bowie WR; Department of Pediatrics, University of Ottawa, Canada.
The purpose of this study was to develop a national perspective on the sexual activity of street youth in Canada and to determine the correlates of risky sexual behavior according to street youth s link to the street. Five categories of street youth (sex industry workers, heavy dru


Streptococcus pneumoniae in human immunodeficiency virus type 1-infected children.
Pediatr Infect Dis J. 1994 Aug;13(8):697-703. Unique Identifier : AIDSLINE MED/95061083
Gesner M; Desiderio D; Kim M; Kaul A; Lawrence R; Chandwani S; Pollack H; Rigaud M; Krasinski K; Borkowsky W; Division of Infectious Disease and Immunology, New York; University Medical Center, NY.
The purpose of this study was to characterize systemic Streptococcus pneumoniae disease in human immunodeficiency virus type 1 (HIV-1)-infected children. All cases of bacteremia and meningitis caused by S. pneumoniae among children less than 18 years old were collected by review of the Microbiology Laboratory records


Megestrol acetate for treatment of anorexia associated with human immunodeficiency virus infection in children.
Pediatr Infect Dis J. 1994 Aug;13(8):754-6. Unique Identifier : AIDSLINE MED/95061100
Brady MT; Koranyi KI; Hunkler JA; Ohio State University College of Medicine and Children's; Hospital, Columbus.
Annual summary of vital statistics--1993.
Pediatrics. 1994 Dec;94(6 Pt 1):792-803. Unique Identifier : AIDSLINE MED/95061107
Wegman ME; School of Public Health, University of Michigan, Ann Arbor; 48109-2029.
A new low in the infant mortality rate was reached again in 1993, at 828.8 deaths per 100,000 live births, a decline of 2% from 848.7 in 1992. Births, marriages, and divorces were all lower, both in number and rate. Deaths and the death rate, however, both increased and, more significantly, the age-adjusted death rate


Natural history of vertically acquired human immunodeficiency virus-1 infection. The European Collaborative Study.
Pediatrics. 1994 Dec;94(6 Pt 1):815-9. Unique Identifier : AIDSLINE MED/95061110
OBJECTIVE. To describe the natural history of vertically acquired human immunodeficiency virus (HIV) infection. DESIGN. This was a prospective follow-up study. SETTING. Ten centers of the European Collaborative Study participated. SUBJECTS. One hundred twenty-four HIV-infected children were born to women known to be i


Perseverance pays off: health care providers' impact on HIV testing decisions by adolescent females.
Pediatrics. 1994 Dec;94(6 Pt 1):878-82. Unique Identifier : AIDSLINE MED/95061120
Goodman E; Tipton AC; Hecht L; Chesney MA; Health Institute, New England Medical Center, Boston,; Massachusetts.
BACKGROUND AND OBJECTIVE. Although HIV counseling and testing of adolescents has increased rapidly in recent years due to increasing HIV seroprevalence rates, little is known about adolescents use of HIV testing services. The aims of this study were to determine what proportion of high risk adolescent girls would use


Effect of perinatally acquired human immunodeficiency virus infection on neurodevelopment in children during the first two years of life.
Pediatrics. 1994 Dec;94(6 Pt 1):883-91. Unique Identifier : AIDSLINE MED/95061121
Nozyce M; Hittelman J; Muenz L; Durako SJ; Fischer ML; Willoughby A; Bronx Lebanon Hospital Center, Department of Pediatrics, New York; 10457.
OBJECTIVE. To determine the timing, extent, and magnitude of neurodevelopmental problems in children with perinatal HIV infection compared to similar uninfected children of HIV-infected women and controls. METHODS. Neurodevelopmental assessments during the first 24 months of life for 21 HIV-infected children born to H


Acquired rectovaginal fistula in human immunodeficiency virus-positive children.
Pediatrics. 1994 Dec;94(6 Pt 1):940-1. Unique Identifier : AIDSLINE MED/95061133
Hyde GA Jr; Sarbah S; Department of Surgery, University of Zimbabwe, Harare, Zimbabwe.
Reducing the risk of human immunodeficiency virus infection associated with illicit drug use. American Academy of Pediatrics. Provisional Committee on Pediatric AIDS.
Pediatrics. 1994 Dec;94(6 Pt 1):945-7. Unique Identifier : AIDSLINE MED/95061135
New policy on HIV and hepatitis B infected health care workers.
N J Nurse. 1994 Oct;24(8):1-2. Unique Identifier : AIDSLINE MED/95061322
Wurmser T
The Denver Nursing Project in Human Caring.
NLN Publ. 1994 Jul;(42-2647):19-37. Unique Identifier : AIDSLINE MED/95061355
Astorino G; Hecomovich K; Jacobs T; Laxson L; Mauro P; Neil RM; Talley S
[Heart involvement in HIV infection]
Nord Med. 1994;109(11):298-9. Unique Identifier : AIDSLINE MED/95061366
Thuesen L; Moller A; Kardiologisk afd, Skejby Sygehus, Arhus N.
Postmortal examinations have shown cardiac involvement in more than 50 percent of patients with AIDS. Echocardiographic studies have shown exudative pericarditis in 18-38 percent of patients with AIDS. The pericardial effusion is usually without haemodynamic consequence, but may be associated with cardiac tamponade. D


D-dimer levels in the cerebrospinal fluid: a marker of central nervous system involvement in neoplastic disease.
Nouv Rev Fr Hematol. 1994 Aug;36(4):321-4. Unique Identifier : AIDSLINE MED/95061383
Eclache V; Vu T; Le Roux G; Laboratoire d'Hematologie, Hopital Avicenne, Bobigny, France.
D-dimer assay was performed on 145 cerebrospinal fluid (CSF) samples from patients with or without neoplastic diseases. Levels of D-dimers were significantly higher in carcinoma and lymphoid malignancies with clinical or biological evidence of central nervous system (CNS) involvement than in diseases without such comp


Exon2 of HIV-2 Tat contributes to transactivation of the HIV-2 LTR by increasing binding affinity to HIV-2 TAR RNA.
Nucleic Acids Res. 1994 Oct 25;22(21):4405-13. Unique Identifier : AIDSLINE MED/95061401
Rhim H; Rice AP; Division of Molecular Virology, Baylor College of Medicine,; Houston, TX 77030.
Human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) express related Tat proteins that are encoded in two exons. Tat proteins bind directly to the TAR RNA element contained in the 5 ends of viral transcripts and thereby stimulate transcription through an as yet unidentified mechanism. We have investigated the


Methylphosphonodiester substitution near the conserved CA dinucleotide in the HIV LTR alters both extent of 3'-processing and choice of nucleophile by HIV-1 integrase.
Nucleic Acids Res. 1994 Oct 25;22(21):4441-8. Unique Identifier : AIDSLINE MED/95061405
Mazumder A; Gupta M; Pommier Y; Laboratory of Molecular Pharmacology, National Cancer Institute,; Bethesda, MD 20892.
We present evidence suggesting that the 3 -processing activity of HIV-1 integrase is dramatically affected by electrostatic and/or steric perturbations 3 to the conserved CA dinucleotide. When the phosphodiester bond 3 to the scissile phosphodiester is replaced by a methylphosphonodiester linkage, 3 -processing decr


Family caregivers of people with AIDS: negotiating partnerships with professional health care providers.
Nurs Res. 1994 Nov-Dec;43(6):324-30. Unique Identifier : AIDSLINE MED/95061430
Powell-Cope GM; College of Nursing, Health Sciences Center, University of South; Florida, Tampa.
The purpose of this grounded theory study was twofold: (a) to examine AIDS family caregivers interactions with professional health care providers, and (b) to evaluate the applicability of Swanson s middle-range theory of caring to characterize these interactions. The sample consisted of 12 family caregivers including


Do nurses' views affect care of i.v. drug users? [news]
Nurs Times. 1994 Sep 21-27;90(38):11-2. Unique Identifier : AIDSLINE MED/95061459
Carroll J
Double versus single glove protection [news]
Nurs Times. 1994 Sep 28-Oct 4;90(39):11-2. Unique Identifier : AIDSLINE MED/95061474
Korniewicz D
Therapy of opportunistic infections.
Pol Arch Med Wewn. 1994 Jun;91(6):483-90. Unique Identifier : AIDSLINE MED/95061612
Drinovec J; KRKA, Marketing and Sales Division, Ljubljana, Slovenia.
Opportunistic infections are becoming really or apparently more frequent because of improved diagnostic techniques, increased age of the people in the developed world, better medical therapy, and higher number of patients living with transplanted organs and on immunosuppressive and glucocorticoid therapy, and also bec


Sexual health: education and counseling perspectives on contraceptive use, HIV and sexuality [editorial]
Patient Educ Couns. 1994 Jul;23(3):141-5. Unique Identifier : AIDSLINE MED/95061696
Visser AP; Ketting E
Modelling and modifying young heterosexuals' HIV-preventive behaviour; a review of theories, findings and educational implications.
Patient Educ Couns. 1994 Jul;23(3):173-86. Unique Identifier : AIDSLINE MED/95061699
Abraham C; Sheeran P
Studies applying social cognitive frameworks such as the health belief model and the theory of reasoned action to HIV-prevention are reviewed. These models suggest that appropriate beliefs, attitudes, social norms, intentions and perceived self-efficacy are sufficient psychological conditions for safer sexual behaviou


Changing adolescents' sexual behaviour: perceived risk, self-efficacy and anticipated regret.
Patient Educ Couns. 1994 Jul;23(3):187-96. Unique Identifier : AIDSLINE MED/95061700
van der Pligt J; Richard R
This article focuses on determinants of adolescent AIDS-related behaviour. First, we will focus on the perception of risk for AIDS and possible optimistic biases in perceived risk. The behavioural consequences of optimism or perceived invulnerability will be briefly discussed. Next, we will focus on other determinants


[Contribution of endothelial cells to the immune processes. Influence of viral infections]
Postepy Hig Med Dosw. 1994;48(3):243-57. Unique Identifier : AIDSLINE MED/95061758
Zaczynska E; Zaklad Immunologii Chorob Zakaznych, Instytutu Immunologii i; Terapii Doswiadczaonej PAN im. L. Hirszwelda, Wroclawiu.
Contribution of endothelial cells to normal immune processes (circulation of leukocytes, immune diapedesis, presentation of antigens) as well as to pathology caused by viral diseases is described. Cytokine secretion and expression of adhesion molecules, particularly during viral infections are described. Permissivenes


Meaning and purpose in the lives of persons with AIDS.
Public Health Nurs. 1994 Oct;11(5):331-6. Unique Identifier : AIDSLINE MED/95061865
Coward DD; School of Nursing, University of Texas at Austin 78701.
Little research has been reported that explores meaning-discovery and meaning-making in persons with AIDS. Self-transcendence experiences, as proposed by Reed (1991), may lead to maintenance or restoration of mental health in persons facing end-of-life issues. Nurses who work with persons with life-threatening illness


[Double neoplastic localization and HTLV-1 infection in Martinique (letter)]
Presse Med. 1994 Jun 11;23(22):1041. Unique Identifier : AIDSLINE MED/95061989
Bois JL; Grolier-Bois L; Grossat-Bernadou N; Le Mab G; Zimmermann S; Escarmant P
Clinical applications of cytokines.
Presse Med. 1994 Jun 18;23(23):1083-91. Unique Identifier : AIDSLINE MED/95062000
Peschel C; Huber C; Aulitzky WE; IIIrd Department of Internal Medicine, Johannes Gutenberg; University Mainz School of Medicine, Germany.
Cytokines are multifunctional signaling peptide molecules which regulate a plethora of cellular activities in the immune system. Cytokines provide a means of communication between the immune system and its non-immune neighbours. Several clinical entities have been recognized as targets for clinical applications includ


[Tuberculosis: a new priority]
Presse Med. 1994 Jul 2-9;23(25):1166-71. Unique Identifier : AIDSLINE MED/95062027
Molimard M; Hirsch A; Chretien J; Service de Pneumologie, Hopital Saint-Louis, Paris.
Tuberculosis is one of the most widespread diseases affecting more than 8 million subjects. The death toll has been estimated at 3 million persons annually. In France , the incidence in 1991 was 15 per 100,000 inhabitants with wide regional variation (37 per 100,000 in Paris and sur


[Multicenter French cohort of adults with HIV infection. Description and course after 4 years of follow-up. SEROCO]
Presse Med. 1994 Sep 17;23(27):1247-51. Unique Identifier : AIDSLINE MED/95062039
Bucquet D; Deveau C; Belanger F; Boufassa F; Desmoulins C; Jadand C; Carre N; Leibovici D; Vilde JL; Rouzioux C; et al; INSERM U292, Le Kremlin-Bicetre.
OBJECTIVES: A prospective multicentric epidemiological study (SEROCO) of subjects with a diagnosis of human immunodeficiency virus (HIV) infection was started on January 1, 1988 in order to better understand the natural history of HIV infection and factors related to outcome. Observations after 4 years of follow-up ar


[Spastic tropical paraplegia associated with HTLV-1 in Central African Republic (letter)]
Presse Med. 1994 Sep 17;23(27):1272. Unique Identifier : AIDSLINE MED/95062048
Herve V; Di Costanzo B; Galmiche J; Kassa Kelembho E; Gessain A; Mathiot C
Preventing HIV infection among adolescents: evaluation of a school-based education program.
Prev Med. 1994 Jul;23(4):409-17. Unique Identifier : AIDSLINE MED/95062049
Main DS; Iverson DC; McGloin J; Banspach SW; Collins JL; Rugg DL; Kolbe LJ; Department of Family Medicine, University of Colorado Health; Sciences Center, Denver 80220.
BACKGROUND. This article reports the results of the impact of a school-based HIV prevention intervention on students knowledge, attitudes, and behavior related to HIV infection. METHODS. Seventeen schools within six Colorado school districts were assigned to either intervention or comparison conditions. Students in 1


[Immune status of patients with non-insulin-dependent diabetes mellitus]
Probl Endokrinol (Mosk). 1994 Jul-Aug;40(4):7-8. Unique Identifier : AIDSLINE MED/95062101
Frolov VM; Peresadin NA; Petrunia AM; Pinskii LL
Immune status of 48 patients with noninsulin-dependent diabetes mellitus (NIDDM) was studied by the cytotoxic test with monoclonal antibodies. The majority of NIDDM patients were found to develop secondary immunodeficiency of the relative hyposuppressor type, the degree of immune shifts augmenting with the disease dur


Induced gene expression of the hypusine-containing protein eukaryotic initiation factor 5A in activated human T lymphocytes.
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10829-33. Unique Identifier : AIDSLINE MED/95062158
Bevec D; Klier H; Holter W; Tschachler E; Valent P; Lottspeich F; Baumruker T; Hauber J; Sandoz Research Institute, Vienna, Austria.
The hypusine-containing protein eukaryotic initiation factor 5A (eIF-5A) is a cellular cofactor critically required for the function of the Rev transactivator protein of human immunodeficiency virus type 1 (HIV-1). eIF-5A localizes in the nuclear and cytoplasmic compartments of mammalian cells, suggesting possible act


Autoantibodies to the alpha/beta T-cell receptors in human immunodeficiency virus infection: dysregulation and mimicry.
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10849-53. Unique Identifier : AIDSLINE MED/95062162
Lake DF; Schluter SF; Wang E; Bernstein RM; Edmundson AB; Marchalonis JJ; College of Medicine, University of Arizona, Tucson 85724.
Autoimmune reactivity is a consequence of infection with human immunodeficiency virus (HIV). We studied serological cross-reactions of purified pooled IgG from sera of HIV-infected individuals by using nested sets of synthetic overlapping peptides duplicating the covalent structures of T-cell receptors (TCRs) and immu


Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1.
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10873-7. Unique Identifier : AIDSLINE MED/95062167
Levy DN; Refaeli Y; MacGregor RR; Weiner DB; Department of Pathology and Laboratory Medicine, University of; Pennsylvania, Philadelphia 19104.
In human immunodeficiency virus (HIV)-positive individuals, the vast majority of infected peripheral blood cells and lymph node cells may be latently or nonproductively infected. The vpr open reading frame of HIV-1 encodes a 15-kDa virion-associated protein, Vpr. The vpr gene has been shown to increase virus replicati


Down-regulation of Rous sarcoma virus long terminal repeat promoter activity by a HeLa cell basic protein.
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11002-6. Unique Identifier : AIDSLINE MED/95062193
Yeh CH; Shatkin AJ; Center for Advanced Biotechnology and Medicine, Piscataway, NJ; 08854.
We have previously isolated a HeLa cell cDNA encoding a 21-kDa polypeptide that is 48% similar to transcription factor IIS. To explore the possibility that p21 plays a role in transcriptional regulation in vivo, we tested the effect of p21 expression on the synthesis of reporter chloramphenicol acetyltransferase (CAT)


Synergistic anti-human immunodeficiency virus type 1 effect of hydroxamate compounds with 2',3'-dideoxyinosine in infected resting human lymphocytes.
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11017-21. Unique Identifier : AIDSLINE MED/95062196
Malley SD; Grange JM; Hamedi-Sangsari F; Vila JR; Compagnie de Developpement Aguettant Societe Anonyme, Lyon,; France.
The cellular models generally used in the in vitro evaluation of anti-human immunodeficiency virus compounds are dividing cells. A model constituted by resting lymphocytes may more accurately reflect a drug s future efficacy in humans, since viral DNA synthesis is known to take place in quiescent cells, creating a res


Human immunodeficiency virus type 1 strains in the lungs of infected individuals evolve independently from those in peripheral blood and are highly conserved in the C-terminal region of the envelope V3 loop.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11378-82. Unique Identifier : AIDSLINE MED/95062271
Itescu S; Simonelli PF; Winchester RJ; Ginsberg HS; Department of Pediatrics, Columbia University, College of; Physicians and Surgeons, New York, NY 10032.
To determine whether human immunodeficiency virus type 1 (HIV-1) strains in the lungs of infected individuals are derived from proviral forms contemporaneously present in the peripheral blood or whether they evolve independently as an autonomous pool of viral quasispecies, HIV-1 envelope V3 domain structures at these


Certain HLA-DR5 and -DR6 major histocompatibility complex class II alleles are associated with a CD8 lymphocytic host response to human immunodeficiency virus type 1 characterized by low lymphocyte viral strain heterogeneity and slow disease progression.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11472-6. Unique Identifier : AIDSLINE MED/95062290
Itescu S; Rose S; Dwyer E; Winchester R; Department of Pediatrics, Columbia University, College of; Physicians and Surgeons, New York, NY 10032.
Either of two structurally related major histocompatibility complex class II alleles, DRB1*1102, which encodes a DR5 specificity, or DRB1*1301, which encodes a DR6 specificity, was found in 67% of individuals responding to human immunodeficiency virus type 1 (HIV-1) infection with a syndrome characterized by persisten


The peptide p2Ca is immunodominant in allorecognition of Ld by beta chain variable region V beta 8+ but not V beta 8- strains.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11482-6. Unique Identifier : AIDSLINE MED/95062292
Connolly JM; Department of Genetics, Washington University School of Medicine,; St. Louis, MO 63110.
An explanation for the vigorous allograft rejection that results from the recognition by CD8+ T cells of allogeneic major histocompatibility complex (MHC) molecules has long eluded immunologists. Recent evidence has demonstrated that alloreactivity involves recognition of both the allogeneic MHC molecule and its assoc


High-affinity reactions between antigen-specific T-cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11487-91. Unique Identifier : AIDSLINE MED/95062293
Sykulev Y; Brunmark A; Tsomides TJ; Kageyama S; Jackson M; Peterson PA; Eisen HN; Center for Cancer Research, Massachusetts Institute of; Technology, Cambridge 02139.
We report here that the intrinsic affinities of the antigen-specific T-cell receptors (TCR) of two unrelated CD8+ T-cell clones for their respective peptide-major histocompatibility complex (MHC) ligands are higher than the values generally thought to prevail for TCR. The TCR of one clone (2C) binds an allogeneic clas


Nonviral and viral delivery of a human immunodeficiency virus protective gene into primary human T cells.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11581-5. Unique Identifier : AIDSLINE MED/95062312
Woffendin C; Yang ZY; Udaykumar; Xu L; Yang NS; Sheehy MJ; Nabel GJ; Howard Hughes Medical Institute, University of Michigan Medical; Center, Ann Arbor.
Because AIDS has been refractory to traditional pharmacologic interventions, alternative approaches have been developed. Although the introduction of specific antiviral genes into T leukemia cells can provide relative resistance to human immunodeficiency virus (HIV) replication, the testing of such genes against prima


Evidence for a single-niche model of positive selection.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11694-8. Unique Identifier : AIDSLINE MED/95062335
Merkenschlager M; Benoist C; Mathis D; Laboratoire de Genetique Moleculaire des Eukaryotes, Centre; National de la Recherche Scientifique, Strasbourg, France.
Thymocyte maturation depends on interactions with thymic stromal elements expressing major histocompatibility complex (MHC) molecules. Mutant mouse strains lacking MHC class I (beta 2-microglobulin-null) or class II (A beta-null) expression fail to generate normal CD8 or CD4 T-cell populations and provide model system


Antigenic implications of human immunodeficiency virus type 1 envelope quaternary structure: oligomer-specific and -sensitive monoclonal antibodies.
Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11699-703. Unique Identifier : AIDSLINE MED/95062336
Broder CC; Earl PL; Long D; Abedon ST; Moss B; Doms RW; Laboratory of Viral Diseases, National Institute of Allergy and; Infectious Diseases, National Institutes of Health, Bethesda, MD; 20892.
A majority of monoclonal antibodies (mAbs) raised against soluble oligomeric human immunodeficiency virus type 1 isolate IIIB (HIV-1IIIB) envelope (env) glycoprotein reacted with conformational epitopes within the gp120 or gp41 subunits. Of 35 mAbs directed against gp41, 21 preferentially reacted with oligomeric env.


[World AIDS Day 1994: AIDS and the family (news)]
Prof Inferm. 1994 Jul-Sep;47(3):55. Unique Identifier : AIDSLINE MED/95062384
Is the message getting across? Effectiveness of health education at informing young people about HIV and AIDS.
Prof Nurse. 1994 Aug;9(11):765-9. Unique Identifier : AIDSLINE MED/95062408
Gilbert S
1. The knowledge base of young people about Aids is improving, but slowly. 2. Young people gain more of their information about Aids from TV and friends than from parents and health professionals. 3. Young people still do not feel vulnerable to Aids, and fail to see it as a disease affecting heterosexual people. 4. Ma


Hypocrellin, from Hypocrella bambuase, is phototoxic to human immunodeficiency virus.
Photochem Photobiol. 1994 Sep;60(3):253-5. Unique Identifier : AIDSLINE MED/95062597
Hudson JB; Zhou J; Chen J; Harris L; Yip L; Towers GH; Department of Pathology, University of British Columbia,; Vancouver, Canada.
Hypocrellin, a photodynamic perylene quinonoid isolated from the Chinese medicinal fungus Hypocrella bambuase, was evaluated for antiviral activity against the human immunodeficiency virus (HIV-1). Hypocrellin was phototoxic to HIV-1, almost as good as the structurally similar plant pigment hypericin, and like hyperic


Cardiovascular reactivity and the course of immune response to an acute psychological stressor.
Psychosom Med. 1994 Jul-Aug;56(4):337-44. Unique Identifier : AIDSLINE MED/95062840
Herbert TB; Cohen S; Marsland AL; Bachen EA; Rabin BS; Muldoon MF; Manuck SB; Department of Psychology, Carnegie Mellon University, Pittsburgh,; PA 15213.
This study evaluated the temporal nature of cellular immune responses, as well as the effects of cardiovascular reactivity on immune responses after exposure to an acute psychological stressor. Lymphocyte subsets and lymphocyte proliferative response to phytohemagglutinin were assessed at baseline and at 5 and 21 minu


Mortality before AIDS: a review of causes of death in young men in the city of Edinburgh (1979-88).
Public Health. 1994 Sep;108(5):357-65. Unique Identifier : AIDSLINE MED/95062900
Ryan DH; Beverley Community Mental Health Centre, North Humberside.
Mortality in young Edinburgh males aged 20-34 years was analysed over the period 1979-88. Proportional mortality was calculated from cause of death data: 23% of deaths were caused by accidents, 16% by infection, 15% by suicide and 9% of deaths were due to cancer. Area mortality rates were measured, and rates were sign


Pulmonary mycobacterial infections in AIDS: characteristic pattern of thallium and gallium scan mismatch.
Radiology. 1994 Nov;193(2):389-92. Unique Identifier : AIDSLINE MED/95062974
Lee VW; Cooley TP; Fuller JD; Ward RJ; Farber HW; Department of Radiology, Boston University School of Medicine,; Boston City Hospital, Mass.
PURPOSE: To evaluate the diagnostic specificity of thallium and gallium scan mismatch as a sign of mycobacterial infection in immunodeficient patients. MATERIALS AND METHODS: Thallium and gallium scans obtained in 56 immunodeficient patients between January 1989 and March 1994 were retrospectively reviewed, with speci


Clival marrow changes in AIDS: findings at MR imaging.
Radiology. 1994 Dec;193(3):623-7. Unique Identifier : AIDSLINE MED/95063025
Eustace S; McGrath D; Albrecht M; Fogt F; Buff B; Longmaid HE; Department of Radiological Sciences, Deaconess Hospital, Harvard; Medical School, Boston, MA 02215.
PURPOSE: To determine the prevalence and clinical significance of marrow changes in the clivus identified at magnetic resonance (MR) imaging in patients with the acquired immunodeficiency syndrome (AIDS). MATERIALS AND METHODS: MR images of the head of 119 patients with AIDS and 119 control subjects were retrospective


[Apoptosis affected by viral genes]
Tanpakushitsu Kakusan Koso. 1994 Oct;39(13):2222-32. Unique Identifier : AIDSLINE MED/95063106
Hashimoto S; Fujiki Y; Meiji Institute of Health Science, Odawara, Japan.
[Human chronic chagasic myocarditis: quantitative study of CD4+ and CD8+ lymphocytes in inflammatory exudates]
Rev Soc Bras Med Trop. 1994 Jul-Sep;27(3):127-34. Unique Identifier : AIDSLINE MED/95063179
Tostes Junior S; Lopes ER; Pereira FE; Chapadeiro E; Patologia Humana da Faculdade de Medicina do Triangulo Mineiro,; Uberaba, MG.
Myocardial exsudate CD4+ and CD8+ lymphocytes were counted in transmural left ventricular free wall frozen sections taken from 10 necropsied chronic cardiac chagasic patients. The cells were labeled with monoclonal antibodies using a streptavidin-biotin technique. We counted: 1) lymphocytes in the total exsudate (LTE)


[Lesions of the gastrointestinal tract in acquired immunodeficiency syndrome: study of 45 consecutive necropsies]
Rev Soc Bras Med Trop. 1994 Jul-Sep;27(3):135-41. Unique Identifier : AIDSLINE MED/95063180
de Carvalho MG; Rodrigues MA; Marques ME; Franco M; Montenegro MR; Departamento de Patologia, Faculdade de Medicina da Universidade; Estadual Paulista (UNESP) Botucatu, SP.
This study was designed to evaluate retrospectively the frequency and etiology of the gastrointestinal (GI) lesions in 45 consecutive necropsies of adult patients with Acquired Immunodeficiency Syndrome (AIDS). Gross descriptions and histological sections of the GI tract, from mouth to anus, were reviewed. The slides


[Skin lesions in progressive disseminated histoplasmosis associated with AIDS]
Rev Soc Bras Med Trop. 1994 Jul-Sep;27(3):171-4. Unique Identifier : AIDSLINE MED/95063185
Lopes JO; Streher LA; Schopf LF; Benevenga JP; Fenalte AA; Righi RA; Servico de Micologia, Hospital Universitario, Universidade; Federal de Santa Maria, RS, Brasil.
The protean manifestations of progressive disseminated histoplasmosis in AIDS patients (PDH/AIDS) specially the cutaneous lesions, may confuse the clinician or the pathologist. A case of PDH/AIDS diagnosed by direct and histologic examination and cultures of subcutaneous nodule aspirate and skin biopsy is reported. Th


[Evaluation of risks related to blood transfusions in industrialized countries]
Rev Epidemiol Sante Publique. 1994;42(5):408-15. Unique Identifier : AIDSLINE MED/95063239
Salamon R; Lawson-Ayayi S; Salmi LR; INSERM U-330, Universite de Bordeaux II, France.
Although numerous progresses have been accomplished, transfusion of labile blood products still has side effects. Transfusion-associated risks are related to the complex environment of the transfusion chain which goes from volunteers for blood collection to receivers of products. Severe hemolytic accidents remain very


[Specific iatrogenic risks to patients with HIV infection]
Rev Epidemiol Sante Publique. 1994;42(5):434-43. Unique Identifier : AIDSLINE MED/95063242
De Tournemire R; Yeni P; Service de Medecine Interne, Hopital Bichat, Paris.
Human immunodeficiency virus-infected patients are exposed to more or less specific iatrogenic diseases. The main characteristics of the risks encountered in this field are described: drug intolerance, mostly to sulfamethoxazole-trimethoprim, is extremely frequent; nucleoside analogue antiviral toxicity is reminiscent


[Residual risk of infections transmitted by blood component transfusion]
Rev Epidemiol Sante Publique. 1994;42(5):463-6. Unique Identifier : AIDSLINE MED/95063245
Courouce AM
[Sacral tuberculous osteitis]
Rev Mal Respir. 1994;11(4):418-20. Unique Identifier : AIDSLINE MED/95063288
Meurice JC; Dore P; Lamotte F; Bataille B; Levard G; Castets M; Patte F; Service de Pneumologie, Centre Hospitalier Universitaire de; Poitiers.
The authors report a case of a 5 year old child suffering from isolated sacral tuberculosis which presented as sudden and total loss of function of the left leg. The rarity of this bony site, and the recurrence at nine months of a presacral abscess after 9 months of anti-tuberculous treatment in an HIV negative child,


[Current methods of anti-infectious prophylaxis in patients with HIV infection]
Rev Mal Respir. 1994;11(4):433-5. Unique Identifier : AIDSLINE MED/95063293
Mayaud C; Parrot A; Cadranel J; Service de Pneumologie, Hopital Tenon, Paris.
Retinal toxicity of high dose intravitreal ganciclovir [see comments]
Retina. 1994;14(3):248-52. Unique Identifier : AIDSLINE MED/95063369
Saran BR; Maguire AM; Retina Service, Scheie Eye Institute, Philadelphia, Pennsylvania; 19104.
BACKGROUND: Intravitreal administration of ganciclovir has been used to treat cytomegalovirus ( CMV ) retinitis in patients with acquired immune deficiency syndrome (AIDS) who are unable to tolerate systemic antiviral therapy.


[The changing spectrum of fever of unknown origin: trends and comparison with previous series at the Salvador Zubiran National Institute of Nutrition]
Rev Invest Clin. 1994 May-Jun;46(3):177-85. Unique Identifier : AIDSLINE MED/95063390
Molina-Gamboa J; Rivera-Morales I; Camacho-Mezquita E; Ponce-de-Leon S; Departamento de Infectologia, INNSZ, Mexico, D.F.
We reviewed 400 medical records of patients admitted because of fever at the National Institute of Nutrition Salvador Zubiran between January 1, 1988 to December 31, 1992. Patient characteristics, diagnostic methods, final diagnosis and patient progress were analyzed, comparing these data with the previous series of t


Clinical patterns of diarrhea in AIDS: etiology and prognosis.
Rev Invest Clin. 1994 May-Jun;46(3):187-96. Unique Identifier : AIDSLINE MED/95063391
Sanchez-Mejorada G; Ponce-de-Leon S; Infectious Diseases Department, National Institute of Nutrition,; Mexico City, Mexico.
OBJECTIVE. To define the etiology and prognosis of diarrhea (acute, intermittent or chronic) in AIDS patients. DESIGN. A retrospective analysis of patients with AIDS and diarrhea. Patterns of diarrhea were defined a priori. Endpoints of interest were etiology, rate of response to therapy, development of chronic diarrh


Drug-resistant tuberculosis: etiology, management and prevention.
Semin Respir Infect. 1994 Jun;9(2):104-12. Unique Identifier : AIDSLINE MED/95063419
O'Brien RJ; Tuberculosis Programme, World Health Organization, Geneva,; Switzerland.
Drug-resistant Mycobacterium tuberculosis inevitably arises from inadequate or inappropriate drug taking or drug prescribing, effectively resulting in monotherapy. This may occur in the patient being treated (acquired resistance) or in a patient who has been infected by another patient with drug resistant tuberculosis


Surrogate markers in AIDS and cancer trials.
Stat Med. 1994 Jul 15-30;13(13-14):1423-35; discussion 1437-40. Unique Identifier : AIDSLINE MED/95063472
Fleming TR; Department of Biostatistics, University of Washington, Seattle; 98195.
There is significant need for rapid yet reliable evaluation of promising new interventions for the treatment of patients with cancer or HIV infection. Considerable attention has been given to identifying replacement or surrogate endpoints for the true clinical efficacy endpoints, in order to reduce the cost, size an


On closed test procedures for dose-response analysis.
Stat Med. 1994 Aug 15;13(15):1583-96. Unique Identifier : AIDSLINE MED/95063486
Rom DM; Costello RJ; Connell LT; Rhone-Poulenc Rorer Central Research, Collegeville, Pennsylvania; 19426.
This paper concerns the testing of a dose-response effect in medical studies. We consider two situations. The first is when the drug effect on a parameter of interest is likely to increase (or decrease) with increasing doses. We propose a procedure based on the closure principle of Peritz combined with an application


[Vaccines against AIDS. It will be a long wait (news)]
Schweiz Rundsch Med Prax. 1994 Oct 18;83(42):1195-7. Unique Identifier : AIDSLINE MED/95063519
[Monitoring of pregnancy in HIV seropositive women]
Rev Fr Gynecol Obstet. 1994 Jul-Sep;89(7-9):387-92. Unique Identifier : AIDSLINE MED/95063593
Bongain A; Ibghi W; Lange AC; Daoudi K; Gillet JY; Service de Gynecologie-Obstetrique et Medecine de la; Reproduction, Hopital Saint-Roch, Nice.
The management of pregnancy in a seropositive woman implies awareness of the effects of the disease on pregnancy and, inversely, of the pregnancy on HIV infection. It is important to be aware of the risk of materno-fetal transmission, as well as of the recent positive results of therapeutic trials of


Search for AIDS vaccine suffers setback [news]
RN. 1994 Oct;57(10):17. Unique Identifier : AIDSLINE MED/95063631
Expression of CD28 on CD8+ and CD4+ lymphocytes during HIV infection.
Scand J Immunol. 1994 Nov;40(5):485-90. Unique Identifier : AIDSLINE MED/95063714
Caruso A; Cantalamessa A; Licenziati S; Peroni L; Prati E; Martinelli F; Canaris AD; Folghera S; Gorla R; Balsari A; et al; Institute of Microbiology, University of Brescia, Italy.
CD28 interaction with B7 molecules, expressed on the membranes of antigen-presenting cells, co-stimulates cytokine production, T-cell proliferation and generation of cytotoxic lymphocytes. The expression of CD28 markers on CD4+ and CD8+ lymphocytes was studied in a group of subjects at various stages of HIV infection.


Human Th0-type T helper-cell clone supports antigen-specific immunoglobulin production in scid/beige-hu mice.
Scand J Immunol. 1994 Nov;40(5):529-34. Unique Identifier : AIDSLINE MED/95063720
Chin LT; Ifversen P; Kristensson K; Wahren B; Carlsson R; Borrebaeck CA; Department of Immunotechnology, Lund University, Sweden.
Tetanus toxoid-specific T cells have been generated from human splenic lymphocytes by an initial 6-day stimulation period with antigen, followed by a proliferation period with recombinant IL-2 and human feeder cells. Proliferating T cells were subsequently cloned by li


[Perception of anxiety in patients requesting anonymous HIV testing]
Schweiz Med Wochenschr. 1994 Nov 5;124(44):1941-4. Unique Identifier : AIDSLINE MED/95063790
Vannotti M; Samaniego M; Guex P; Rossi I; Policlinique medicale universitaire, Lausanne.
To determine the manifestations of anxiety in subjects seeking anonymous HIV testing and the aptitude of professionals to perceive it, we administered a semi-structured questionnaire to 481 persons, 281 before and 200 after instructing the practitioners to better decode anxiety during the consultation. The perception


[True aneurysm of the ascending aorta in HIV disease]
Schweiz Med Wochenschr. 1994 Nov 19;124(46):2083-7. Unique Identifier : AIDSLINE MED/95063815
Boggian K; Leu HJ; Schneider J; Turina M; Oertle D; Medizinische Klinik A, Kantonsspital St. Gallen.
A 31-year-old male who presented with a true aneurysm of the ascending aorta had for 5 years been seropositive for HIV-1 following intravenous drug abuse. Elective aneurysmectomy was refused. Controls by computerized tomography and echocardiography gave evidence of a progressive dilatation during the following 8 month


[Sulfadiazine nephrolithiasis and nephropathy]
Schweiz Med Wochenschr. 1994 Nov 19;124(46):2100-5. Unique Identifier : AIDSLINE MED/95063818
Furrer H; von Overbeck J; Jaeger P; Hess B; Medizinische Universitatspoliklinik, Inselspital Bern.
Sulfadiazine-nephropathy and -nephrolithiasis were well known complications of high dose sulfadiazine therapy 50 years ago. In the last few years high dose sulfadiazine therapy has been widely used for treatment of toxoplasmic encephalitis in AIDS patients. As a consequence sulfadiazine-nephropathy and -nephrolithiasi


On consumption [letter; comment]
S D J Med. 1994 Sep;47(9):326. Unique Identifier : AIDSLINE MED/95063881
Welty TK; Volmer L
Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication.
Science. 1994 Nov 4;266(5186):801-5. Unique Identifier : AIDSLINE MED/95063915
Lori F; Malykh A; Cara A; Sun D; Weinstein JN; Lisziewicz J; Gallo RC; Laboratory of Tumor Cell Biology, National Cancer Institute,; National Institutes of Health, Bethesda, MD 20892-4255.
Hydroxyurea, a drug widely used in therapy of several human diseases, inhibits deoxynucleotide synthesis--and, consequently, DNA synthesis--by blocking the cellular enzyme ribonucleotide reductase. Hydroxyurea inhibits human immunodeficiency virus-type 1 (HIV-1) DNA synthesis in activated peripheral blood lymphocytes


Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody.
Science. 1994 Nov 11;266(5187):1024-7. Unique Identifier : AIDSLINE MED/95063934
Burton DR; Pyati J; Koduri R; Sharp SJ; Thornton GB; Parren PW; Sawyer LS; Hendry RM; Dunlop N; Nara PL; et al; Department of Immunology, Scripps Research Institute, La Jolla,; CA 92037.
The ability of antibodies to neutralize diverse primary isolates of human immunodeficiency virus-type 1 in vitro has been questioned, with implications for the likely efficacy of vaccines. A recombinant human antibody to envelope glycoprotein gp120 was generated and used to show that primary isolates are not refractor


Xenotransplants set to resume [news]
Science. 1994 Nov 18;266(5188):1148-51. Unique Identifier : AIDSLINE MED/95063974
Nowak R
AIDS vaccines. At conference, hope for success is further attenuated [news]
Science. 1994 Nov 18;266(5188):1154. Unique Identifier : AIDSLINE MED/95063976
Cohen J
UN readies new global AIDS plan [news]
Science. 1994 Nov 25;266(5189):1312-3. Unique Identifier : AIDSLINE MED/95063999
Balter M
AIDS. CDC reorganization prompts concern [news]
Science. 1994 Nov 25;266(5189):1313. Unique Identifier : AIDSLINE MED/95064000
Thompson L
The next steps toward a global AIDS vaccine.
Science. 1994 Nov 25;266(5189):1335-7. Unique Identifier : AIDSLINE MED/95064010
Koff WC; United Biomedical, Hauppauge, NY 11790.
Sexual activity before marriage in sub-Saharan Africa.
Soc Biol. 1994 Spring-Summer;41(1-2):44-60. Unique Identifier : AIDSLINE MED/95064133
Gage AJ; Meekers D; Demographic and Health Surveys, Macro International Inc.,; Calverton, Maryland 20705.
Throughout sub-Saharan Africa there is notable concern about the consequences of premarital sexual intercourse, such as illegal abortions and pregnancy-related school dropouts, and the potential risk of HIV infection. Using data from the Demographic and Health Surveys, the authors investigated sexual activity among ne


What is a chronic disease? The effects of a re-definition in HIV and AIDS.
Soc Sci Med. 1994 Aug;39(4):591-7. Unique Identifier : AIDSLINE MED/95064152
Clarke A; Department of Public Health and Policy, London School of Hygiene; and Tropical Medicine, England.
HIV disease has recently come to be defined as a chronic disease from both policy and clinical points of view. This paper investigates the meaning and some possible implications of the redefinition. The first section examines the features identifiable from medical texts used to define a disorder as either acute or chr


Dapsone therapy causing sulfone syndrome and lethal hepatic failure in an HIV-infected patient.
South Med J. 1994 Nov;87(11):1145-6. Unique Identifier : AIDSLINE MED/95064197
Chalasani P; Baffoe-Bonnie H; Jurado RL; Department of Medicine, Emory University School of Medicine,; Atlanta, Ga.
A 34-year-old woman with HIV infection and no other opportunistic infections presented a classic sulfone syndrome, manifested by fever, rash, hemolytic anemia, and fulminant hepatitis due to dapsone hypersensitive reaction, with a fatal outcome. We believe this is the first reported fatal complication of dapsone in an


Does the HIV/AIDS campaign deserve a larger slice of the health budget? [editorial]
S Afr Med J. 1994 Apr;84(4):191. Unique Identifier : AIDSLINE MED/95064335
Ncayiyana DJ
Is the 1993/4 AIDS programme budget adequate?
S Afr Med J. 1994 Apr;84(4):191-3. Unique Identifier : AIDSLINE MED/95064336
Schneider H; McIntyre J; Department of Community Health, University of the Witwatersrand,; Johannesburg.
National HIV surveillance--South Africa, 1990-1992.
S Afr Med J. 1994 Apr;84(4):195-200. Unique Identifier : AIDSLINE MED/95064338
Kustner HG; Swanevelder JP; Van Middelkoop A; Department of National Health and Population Development,; Pretoria.
The findings of three annual surveys of women attending antenatal clinics (at the end of 1990, 1991 and 1992) are presented here. These surveys form part of the National HIV Surveillance Programme. This programme is probably the most useful means of monitoring the trend and distribution of the epidemic. In all strata,


HIV-associated nephropathy--an initial presentation in an HIV-positive patient.
S Afr Med J. 1994 Apr;84(4):223-4. Unique Identifier : AIDSLINE MED/95064345
Bates WD; Muller N; van de Wal BW; Jacobs JC; Department of Anatomical Pathology, University of Stellenbosch.
The lesions of HIV-associated nephropathy occur in patients with AIDS, AIDS-related complex and in individuals clinically asymptomatic for HIV infection. We report on a 35-year-old black South African woman who presented with nephrotic syndrome and renal failure. The renal biopsy appearance suggested HIV infection and


Paediatric HIV infection in a rural Zululand hospital [letter]
S Afr Med J. 1994 Apr;84(4):234-6. Unique Identifier : AIDSLINE MED/95064359
Wilkinson D; Habgood LC; Scrace M
Isolation of herpes simplex virus from sexually transmitted disease patients in Ibadan, Nigeria.
Sex Transm Dis. 1994 Jul-Aug;21(4):187-90. Unique Identifier : AIDSLINE MED/95064367
Oni AA; Adu FD; Ekweozor CC; Department of Virology, College of Medicine, University College; Hospital, Ibadan, Nigeria.
BACKGROUND AND OBJECTIVES: Despite the public health importance of herpes simplex virus infection in Nigeria , attempts have not been made to isolate and identify the virus. GOAL OF THE STUDY: To isolate, identify, and type the virus from patients attending a sexually transmitted d


The association between lack of male circumcision and risk for HIV infection: a review of the epidemiological data.
Sex Transm Dis. 1994 Jul-Aug;21(4):201-10. Unique Identifier : AIDSLINE MED/95064370
Moses S; Plummer FA; Bradley JE; Ndinya-Achola JO; Nagelkerke NJ; Ronald AR; Department of Community Health, University of Nairobi, Kenya.
BACKGROUND AND OBJECTIVES: Whether male circumcision reduces the risk of acquiring human immunodeficiency virus (HIV) infection remains controversial. STUDY DESIGN: As there have now been a number of studies conducted that have examined this issue, we undertook to review their findings. Thirty epidemiological studies


Condom use by Norplant users at risk for sexually transmitted diseases.
Sex Transm Dis. 1994 Jul-Aug;21(4):217-9. Unique Identifier : AIDSLINE MED/95064373
Humphries HO; Bauman KE; Department of Health Behavior and Health Education, School of; Public Health, University of North Carolina at Chapel Hill 27599.
BACKGROUND: Norplant is highly effective for long-term pregnancy prevention. Norplant users might not use condoms, and they may acquire human immunodeficiency virus (HIV) and other sexually transmitted diseases as a consequence. GOAL OF THIS STUDY: The goal of this study was to assess condom use among Norplant users a


Alcohol and other substance use in STD clinic patients: relationships with STDs and prevalent HIV infection.
Sex Transm Dis. 1994 Jul-Aug;21(4):220-5. Unique Identifier : AIDSLINE MED/95064374
Zenilman JM; Hook EW 3rd; Shepherd M; Smith P; Rompalo AM; Celentano DD; Division of Infectious Diseases, Johns Hopkins University School; of Medicine, Baltimore.
BACKGROUND AND OBJECTIVES: Sexually transmitted diseases have been epidemiologically linked to a variety of high-risk behaviors, including substance abuse. However, the relationship between alcohol consumption and risk for specific STDs has not been explored previously. GOAL OF THIS STUDY: We hypothesized that alcohol


Single dose azithromycin for the treatment of chancroid: a randomized comparison with erythromycin.
Sex Transm Dis. 1994 Jul-Aug;21(4):231-4. Unique Identifier : AIDSLINE MED/95064376
Tyndall MW; Agoki E; Plummer FA; Malisa W; Ndinya-Achola JO; Ronald AR; WHO Collaborating Centre for Research and Training in Sexually; Transmitted Diseases, Department of Medical Microbiology,; University of Nairobi, Kenya.
BACKGROUND AND OBJECTIVES: Chancroid is endemic in sub-Saharan Africa and enhances the sexual transmission of the human immunodeficiency virus Type 1 (HIV-1). Azithromycin is an orally absorbed macrolide antibiotic that is active against Haemophilus ducreyi, the causative agent of chancroid, and has pharmacokinetic pr


Detection of human immunodeficiency virus antibody among homosexual men from Bombay.
Sex Transm Dis. 1994 Jul-Aug;21(4):235-6. Unique Identifier : AIDSLINE MED/95064377
Nandi J; Kamat H; Bhavalkar V; Banerjee K; National Institute of Virology, Pune, India.
BACKGROUND AND OBJECTIVES: In India , heterosexual transmission of HIV-infection is considered to be the major mode of transmission. However, no report is available on transmission of HIV-infection among homosexually active men. The prevalence of human immunodeficiency virus-1 (HIV-1


The hazards of oral sex [letter]
Sex Transm Dis. 1994 Jul-Aug;21(4):241-2. Unique Identifier : AIDSLINE MED/95064379
Carlin E; Miller L; Boag F
HIV status does not affect microbiologic spectrum or neurologic outcome in spinal infections.
Surg Neurol. 1994 Nov;42(5):417-23. Unique Identifier : AIDSLINE MED/95064455
Heary RF; Hunt CD; Krieger AJ; Vaid C; Section of Neurological Surgery, University of Medicine and; Dentistry of New Jersey, New Jersey Medical School, Newark.
The impact of human immunodeficiency virus (HIV) on the clinical presentations, causative organisms, and neurologic outcomes of patients with spinal infections is reviewed. Thirty-two patients with spinal epidural abscesses, vertebral osteomyelitis, or both were treated at an urban hospital over a 42-month period. Thi


Spinal subdural abscess: successful treatment with limited drainage and antibiotics in a patient with AIDS.
Surg Neurol. 1994 Nov;42(5):424-7. Unique Identifier : AIDSLINE MED/95064456
Sathi S; Schwartz M; Cortez S; Rossitch E Jr; Division of Neurosurgery, Brigham and Women's Hospital, Harvard; Medical School, Boston.
The authors present a case of Staphylococcus aureus spinal subdural abscess in a patient with AIDS. Although complete surgical drainage has been strongly advocated in the literature, this patient made a complete neurologic and symptomatic recovery and radiographically demonstrated resolution of the abscess with only l


Ophthalmoplegia associated with AIDS.
Surv Ophthalmol. 1994 Jul-Aug;39(1):43-51. Unique Identifier : AIDSLINE MED/95064499
Hedges TR 3rd; Department of Ophthalmology, Tufts University, New England Eye; Center, Boston, Massachusetts.
A 34-year-old man with AIDS was admitted to the hospital with a one-week history of cough, chest pain, and fever. Radiography revealed a cavitating left upper lobe lesion. Two weeks later he developed a headache associated with a contrast enhancing lesion in the right parietal lobe. The patient had a progressive downh


Pulmonary pathology in AIDS: atypical Pneumocystis carinii infection and lymphoid interstitial pneumonia.
Thorax. 1994;49 Suppl:S46-55. Unique Identifier : AIDSLINE MED/95064641
Saldana MJ; Mones JM; University of Miami School of Medicine, Florida.
Impact of replacement therapy on the evolution of HIV infection in hemophiliacs.
Thromb Haemost. 1994 Jun;71(6):678-83. Unique Identifier : AIDSLINE MED/95064645
Berntorp E; Department of Coagulation Disorders, University of Lund, Malmo; General Hospital, Sweden.
Immune tolerance in hemophilia-principal results from the International Registry. Report of the factor VIII and IX Subcommittee.
Thromb Haemost. 1994 Jul;72(1):155-8. Unique Identifier : AIDSLINE MED/95064682
Mariani G; Ghirardini A; Bellocco R; Department of Human Biopathology, University of Rome, Italy.
40 Hemophilia Centers from the USA, Canada , Europe and Japan referred to the International Registry 204 patients with haemophilia A, treated by Immune Tolerance (IT) Protocols over the past two decades because of the presence of an inhibitor to F


Clinical factors associated with progression to AIDS in the Italian cohort of HIV-positive hemophiliacs. G.I.C.C. Gruppo Italiano Coagulopatie Congenite.
Thromb Haemost. 1994 Jul;72(1):33-8. Unique Identifier : AIDSLINE MED/95064691
Schinaia N; Ghirardini AM; Mazzucconi MG; Tagariello G; Morfini M; Chiarotti F; National AIDS Operational Center, Istituto Superiore di Sanita,; Roma, Italy.
This study updates estimates of the cumulative incidence of AIDS among Italian patients with congenital coagulation disorders (mostly hemophiliacs), and elucidates the role of age at seroconversion, type and amount of replacement therapy, and HBV co-infection in progression. Information was collected both retrospectiv


[Infection control legislation. On infection control legislation and participation of the Helsedirektoratet/Helsetilsynet in the legislative process]
Tidsskr Nor Laegeforen. 1994 Oct 20;114(25):2983-4. Unique Identifier : AIDSLINE MED/95064733
Lerche C; Alvik A; Tveitan K; Statens helsetilsyn, Oslo.
[The extent of HIV testing in the Norwegian population seen in relation to sex behavior]
Tidsskr Nor Laegeforen. 1994 Oct 30;114(26):3064-7. Unique Identifier : AIDSLINE MED/95064744
Magnus P; Samuelsen SO; Eskild A; Stigum H; Seksjon for epidemiologi, Statens Institut for Folkehelse, Oslo.
To estimate the incidence of clinical HIV-testing and the association between testing and sexual habits, data from a 1992 population-based, anonymous survey of sexual behaviour were analysed. The sample size was 10,000 subjects between 18 and 60 years of age and the response rate was 48%. 15% of the males and 13% of t


Fetal hematopoietic alterations after maternal exposure to ethylene glycol monomethyl ether: prolymphoid cell targeting.
Toxicol Appl Pharmacol. 1994 Nov;129(1):53-60. Unique Identifier : AIDSLINE MED/95064817
Holladay SD; Comment CE; Kwon J; Luster MI; Department of Biomedical Sciences, Virginia-Maryland Regional; College of Veterinary Medicine, Blacksburg, Virginia 24061-0442.
Ethylene glycol monomethyl ether (EGME), which is extensively used in the chemical industries, has been associated with hematologic disorders in both humans and experimental animals. EGME is metabolized to the active compound methoxy-acetic acid (MAA), which readily crosses the placenta and impairs fetal development.


Care of the patient with AIDS and cytomegalovirus retinitis.
Todays OR Nurse. 1994 Sep-Oct;16(5):36-40. Unique Identifier : AIDSLINE MED/95064975
Frederick MC
1. The most common intraocular infection of persons with AIDS is cytomegalovirus ( CMV ) retinitis, affecting an estimated 20%. Untreated, CMV retinitis is a progressive and destructive infection that results in blindness. 2. I


Excess morbidity related to HIV infection.
Trans R Soc Trop Med Hyg. 1994 May-Jun;88(3):295. Unique Identifier : AIDSLINE MED/95064991
King R; Fox E; Twagirakristu JB; Karita E; Allen S; Project San Francisco, Kigali, Rwanda.
Contribution of serological tests to the diagnosis of visceral leishmaniasis in patients infected with the human immunodeficiency virus.
Trans R Soc Trop Med Hyg. 1994 May-Jun;88(3):301-2. Unique Identifier : AIDSLINE MED/95064995
Gari-Toussaint M; Lelievre A; Marty P; Le Fichoux Y; Laboratoire de Parasitologie-Mycologie, Hopital de Cimiez, Nice,; France.
Type 1 reactions in leprosy, neuritis and steroid therapy: the impact of the human immunodeficiency virus.
Trans R Soc Trop Med Hyg. 1994 May-Jun;88(3):315-6. Unique Identifier : AIDSLINE MED/95065002
Bwire R; Kawuma HJ; St Francis Leprosy Centre, Buluba, Finja, Uganda.
The incidence of type 1 reactions and neuritis among HIV seronegative and HIV seropositive leprosy patients was investigated. HIV seropositivity was associated with an increased incidence of type 1 reactions among multibacillary (MB) patients, which were observed in 9 of 12 seropositive MB patients and in 8 of 40 HIV


Error contributes to the risk of transmissible disease [letter]
Transfusion. 1994 Nov-Dec;34(11):1016. Unique Identifier : AIDSLINE MED/95065028
Linden JV
Rejection of rat skin xenografts by either murine CD4 or CD8 T cells.
Transplantation. 1994 Nov 15;58(9):1020-6. Unique Identifier : AIDSLINE MED/95065061
Click RE; Weisberg D; White J; Reichenbach D; Jamieson SW; Department of Biology, University of Wisconsin, River Falls; 54022.
Although xenografts can be rejected by humoral or cellular mechanisms, the relative contribution of each remains unknown for any given recipient-donor combination. Moreover, the cells involved in cell-mediated events, as well as the mechanisms by which these cells recognize xenoantigens, remain controversial. It would


[Is a current HIV test necessary in insurance related medical examinations?]
Versicherungsmedizin. 1994 Oct 1;46(5):177. Unique Identifier : AIDSLINE MED/95065384
Kuhn T
Viral diseases as a threat to free-living wild cats (Felis silvestris) in continental Europe.
Vet Rec. 1994 Jun 18;134(25):651-2. Unique Identifier : AIDSLINE MED/95065451
Artois M; Remond M; Laboratoire d'Etudes sur la Rage et la Pathologie des Animaux; Sauvages, Malzeville, France.
Putative bovine B cell lineage tumor in sporadic bovine leukosis.
Vet Immunol Immunopathol. 1994 Aug;42(2):185-97. Unique Identifier : AIDSLINE MED/95065626
Ishiguro N; Shinagawa T; Matsui T; Shinagawa M; Department of Veterinary Public Health, Obihiro University of; Agriculture and Veterinary Medicine, Hokkaido, Japan.
Two calves (C924 and C928) clinically identified as suffering from the calf type of sporadic bovine leukosis (SBL) were examined for immunophenotypical distribution of their peripheral blood lymphocytes (PBL) with T cell or B cell specific monoclonal antibodies (mAbs). Flow cytometric profile analysis indicated that b


The role of Nef in the replication cycle of the human and simian immunodeficiency viruses.
Virology. 1994 Nov 15;205(1):1-6. Unique Identifier : AIDSLINE MED/95065640
Cullen BR; Howard Hughes Medical Institute, Duke University Medical Center,; Durham, North Carolina 27710.
Activity and cleavage site specificity of an anti-HIV-1 hairpin ribozyme in human T cells.
Virology. 1994 Nov 15;205(1):121-6. Unique Identifier : AIDSLINE MED/95065643
Yamada O; Kraus G; Leavitt MC; Yu M; Wong-Staal F; Department of Medicine and Biology, University of California, San; Diego 92093-0665.
Human CD4+ T cells (Molt-4) were transduced with retroviral vectors containing a hairpin ribozyme which targets the rev/env coding region of HIV-1 RNA (HXB2: 8629-8644). This target sequence is conserved among many HIV-1 clones, including the prototype virus HXB2, but the infectious clone SF2 contains a single nucleot


Isolation and envelope sequence of a highly divergent HIV-1 isolate: definition of a new HIV-1 group.
Virology. 1994 Nov 15;205(1):247-53. Unique Identifier : AIDSLINE GENBANK/X80020
Charneau P; Borman AM; Quillent C; Guetard D; Chamaret S; Cohen J; Remy G; Montagnier L; Clavel F; CNRS URA 1157, Departement Sida et Retrovirus, Institut; Pasteur, Paris, France.
We report here the isolation and envelope sequence of a divergent HIV-1 isolate from a French woman with AIDS. This virus, HIV-1VAU, is closely related to the recently described Cameroonian viral isolates HIV-1ANT70 and HIV-1MVP5180, until now designated HIV-1 subtype O. Phylogenetic analysis reveals that the three vi


Substitution mutations affecting a small region of the Moloney murine leukemia virus MA gag protein block assembly and release of virion particles.
Virology. 1994 Nov 15;205(1):336-44. Unique Identifier : AIDSLINE MED/95065669
Granowitz C; Goff SP; Department of Biochemistry and Molecular Biophysics, College of; Physicians and Surgeons, Columbia University, New York, New York; 10032.
A series of substitution mutations affecting the Moloney murine leukemia virus MA protein were introduced into a cloned proviral DNA, and the mutant DNAs were tested for their biological activity in NIH/3T3 cells and COS cells. Many of the mutant viruses were viable and replicated with kinetics indistinguishable from


Pseudotyped REV/SRV retroviruses reveal restrictions to infection and host range within members of the same receptor interference group.
Virology. 1994 Nov 15;205(1):345-51. Unique Identifier : AIDSLINE MED/95065671
Koo HM; Parthasarathi S; Ron Y; Dougherty JP; Department of Molecular Genetics and Microbiology, Robert Wood; Johnson Medical School, University of Medicine and Dentistry of; New Jersey, Piscataway 08854-5635.
The reticuloendotheliosis virus (REV) group of retroviruses and type D simian retroviruses (SRV) belong to the same receptor interference group. The cellular receptor for these viruses has not yet been identified. In order to study the distribution of the receptor and to identify a receptor negative cell line, vector


CD4 expressing human 293 cells as a tool for studies in HIV-1 replication: the efficiency of translational frameshifting is not altered by HIV-1 infection.
Virology. 1994 Nov 15;205(1):371-5. Unique Identifier : AIDSLINE MED/95065675
Reil H; Hoxter M; Moosmayer D; Pauli G; Hauser H; GBF-Gesellschaft fur Biotechnologische Forschung mbH,; Braunschweig, FRG.
An adherent human cell line (293) was made susceptible for HIV-1 infection by transfer of a CD4 expression plasmid. These cells could be infected with HIV-1 and produced infectious virus up to a titer of 10(6) TCID50/ml releasing p24 protein up to 1 micrograms/ml. Since they can be efficiently transfected with reporte


2-LTR circular viral DNA as a marker for human immunodeficiency virus type 1 infection in vivo.
Virology. 1994 Dec;205(2):470-8. Unique Identifier : AIDSLINE MED/95065692
Pauza CD; Trivedi P; McKechnie TS; Richman DD; Graziano FM; Department of Pathology and Laboratory Medicine, University of; Wisconsin, Madison 53706.
The unintegrated viral DNA found in human immunodeficiency virus type 1 infection includes linear and circular forms. We targeted the circular form containing two copies of the viral long terminal repeat (2-LTR circle) and developed specific assays to detect this molecule in peripheral blood mononuclear cells from HIV


Mapping of functional domains for HIV-2 gag assembly into virus-like particles.
Virology. 1994 Dec;205(2):496-502. Unique Identifier : AIDSLINE MED/95065695
Luo L; Li Y; Dales S; Kang CY; Department of Zoology, Faculty of Science, University of Western; Ontario, London, Canada.
The human immunodeficiency virus type 2 gag precursor protein, pr41, self assembles as virus-like particles (VLP) when the gag gene is expressed in insect cells. To map the functional domains for HIV-2 gag VLP formation, a series of deletion mutants was constructed by removing sequentially the C-terminal region of HIV


Infection of cats with molecularly cloned and biological isolates of the feline immunodeficiency virus.
Virology. 1994 Dec;205(2):546-53. Unique Identifier : AIDSLINE MED/95065702
Sparger EE; Beebe AM; Dua N; Himathongkam S; Elder JH; Torten M; Higgins J; Department of Medicine