HIV-associated malignancies in children: a survey of the Childrens Cancer Group (Meeting abstract). NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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HIV-associated malignancies in children: a survey of the Childrens Cancer Group (Meeting abstract).

Proc Annu Meet Am Assoc Cancer Res; 36:A1678 1995. Unique Identifier : AIDSLINE ICDB/95609453
Rabkin CS; Robison LL; Buckley J; Meadows AT; Nicholson HS; NCI, Bethesda, MD 20892

Abstract: In adults, HIV infection is known to increase the incidence of non-Hodgkin's lymphoma (NHL) and Kaposi's sarcoma; the incidence of other tumors is relatively unaffected. To determine if children have a different pattern of HIV-associated malignancies, we examined the experience of member institutions of the Childrens Cancer Group (CCG). In a preliminary survey, 93 CCG centers reported treating 62 HIV-infected children, at least 43 of whom were infected before cancer diagnosis. Leiomyosarcomata and benign leiomyomata comprised 10% of the HIV-associated tumors. Conversely, NHL was less common than predicted from studies of adults with HIV infection (31 cases observed vs 100 expected). These data confirm the excess of smooth muscle tumors in pediatric HIV infection, which has not been documented in adults. The epidemiology of HIV-associated malignancy differs between children and adults, suggesting the existence of co-factors related to growth and/or maturation. Detailed data relating to HIV infection, malignancy, treatment, and outcome in pediatric cases of HIV-associated tumors are now being collected.
Keywords: Adult Age Factors Child Cross-Sectional Studies Human HIV Infections/*EPIDEMIOLOGY Incidence Leiomyoma/*EPIDEMIOLOGY Leiomyosarcoma/*EPIDEMIOLOGY Lymphoma, AIDS-Related/*EPIDEMIOLOGY Sarcoma, Kaposi's/*EPIDEMIOLOGY Skin Neoplasms/*EPIDEMIOLOGY Soft Tissue Neoplasms/*EPIDEMIOLOGY United States/EPIDEMIOLOGY ABSTRACTKWDadultagefactorschildcross-sectionalstudieshumanhivinfections/KWDepidemiologyincidenceleiomyoma/KWDepidemiologyleiomyosarcoma/KWDepidemiologylymphoma,aids-related/KWDepidemiologysarcoma,kaposi's/KWDepidemiologyskinneoplasms/KWDepidemiologysofttissueneoplasms/KWDepidemiologyunitedstates/epidemiologyabstract
951230
M95C3238

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