A retrospective review of 56 patients with primary central nervous system lymphoma: Outcomes of radiation alone versus combined modality treatment (Meeting abstract).

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

A retrospective review of 56 patients with primary central nervous system lymphoma: Outcomes of radiation alone versus combined modality treatment (Meeting abstract).

Proc Annu Meet Am Soc Clin Oncol; 14:A297 1995. Unique Identifier : AIDSLINE ICDB/95613451
Kiehl R; Roberts H; Kim J; Cardinale J; Knowlton A; Knisely J; Dept. Therapeutic Radiology, Yale Univ., School of Medicine, New; Haven, CT 06510

Abstract: A total of 56 cases of primary central nervous system lymphoma (PCNSL) were seen at Yale-New Haven Hospital and 2 affiliate teaching hospitals from 1970-1993. Pathologic diagnosis was confirmed by a single neuropathologist. Our charts and hospital records were reviewed to exclude systemic lymphoma and to obtain data on therapy and outcome. Nineteen cases were AIDS-related, 2 were immune suppressed, 35 were non-AIDS PCNSL: 33 males, 23 females. Interestingly, 3 (5.4%) of our non-AIDS patients had previous colon cancer; 8 (14%) had hormonal disorders (hypothyroidism, panhypopituitarism, hypoadrenalism, etc.). Various radiation fractionations (RT), surgery (B: biopsy, CR: complete resection, PR: partial resection) and chemotherapy (C) regimens (CHOP, DHAP, CVPP, intrathecal MTX, Ara-C) were utilized during the analyzed period. AIDS patients were in Group 1; All others: Group 2 (B + RT), Group 3 (CR/PR + RT), Group 4 (B + RT + C), Group 5 (CR/PR + RT + C). Data are shown in a table. Conclusions: (1) Total dose, fraction size had no influence on the survival of AIDS PCNSL; (2) Patients who received some form of chemotherapy after radiotherapy had a significantly longer median survival than with comparable radiation alone; (3) Patients with complete or partial resection of a solitary lesion followed by radiation and chemotherapy had considerable longer median survival than with biopsy followed by radiation and chemotherapy.

Keywords: Adult Aged Antineoplastic Agents, Combined/THERAPEUTIC USE Brain Neoplasms/DRUG THERAPY/*RADIOTHERAPY/SURGERY Combined Modality Therapy Cranial Irradiation Craniotomy Female Follow-Up Studies Human Lymphoma/DRUG THERAPY/*RADIOTHERAPY/SURGERY Lymphoma, AIDS-Related/DRUG THERAPY/*RADIOTHERAPY/SURGERY Male Middle Age Retrospective Studies ABSTRACT
951230
M95C3233

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