Cell cycle kinetics and DNA ploidy in head and neck squamous cell cancer (HNSCC) (Meeting abstract).

Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

Cell cycle kinetics and DNA ploidy in head and neck squamous cell cancer (HNSCC) (Meeting abstract).

Proc Annu Meet Am Soc Clin Oncol; 14:A342 1995. Unique Identifier : AIDSLINE ICDB/95613496
Danova M; DeRenzis MR; Benazzo M; Corbella F; Mazzini G; Riccardi A; Ascari E; Internal Medicine and Medical Oncology, Univ. and IRCCS S.; Matteo, Pavia, Italy

Abstract: Cell cycle kinetics and DNA ploidy may add prognostic information in HNSCC and provide a rationale for improving the results of radio (RT) or chemotherapy (CT). We have addressed these points using the in vivo incorporation of bromodeoxyuridine (BUDR) coupled with bivariate (DNA/BUDR) flow cytometry in a series of 232 pts (median age 62 yr, range 45-74; 60 larynx, 45 oral cavity, 63 oropharynx and 64 nasopharynx) in different clinical stages (40 SI, 64 SII, 68 SIII, 60 SIV). 134/232 (57.7%) pts were aneuploid with a median DNA index of the aneuploid peak of 1.4 (range 1.2-2.2). Median values of BUDR-labeling index (LI) DNA synthesis time and potential doubling time (Tpot) were 8.9% (2-17.6), 11.5 hr (5-28) and 5.5 days (2-30), respectively. DNA ploidy and BUDR-LI were not significantly correlated with tumor site, clinical stage or pathological grading but DNA-aneuploid tumors showed shorter Tpot (4.1 days) than DNA-diploid ones (8 days; p less than 0.05). An analysis of the predictive power of biological and clinical factors with respect to both the tumor response and the relapse-free interval in 2 groups of SIII-SIV pts (74 pts treated with RT and 85 pts treated with RT + DDP/5-FU-based CT) showed a statistical significance only for the lymphonodal status (p less than 0.0005 and p less than 0.005) followed by the Tpot (p less than 0.005 and p less than 0.05). These results should be considered in designing kinetically based clinical trials for HNSCC.

Keywords: Aged Carcinoma, Squamous Cell/GENETICS/*PATHOLOGY *Cell Cycle Flow Cytometry Head and Neck Neoplasms/GENETICS/*PATHOLOGY Human Middle Age *Ploidies ABSTRACT
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