Herpes drug study halted. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023. NLM AIDSLINE Important note: Information in this article was accurate in 1995. The state of the art may have changed since the publication date.

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Herpes drug study halted. Clearinghouse, P.O. Box 6003, Rockville, MD 20849-6003. 800-458-5231 ext. 5023.

Posit Aware. 1995 May/Jun;:5. Unique Identifier : AIDSLINE AIDS/95700392

Abstract: Trial ACTG 204, involving the anti-herpes drug valacyclovir, has been halted by a safety monitoring board after initial data showed that participants have poorer survival rates compared to patients receiving standard medications. Valacycolvir produced more renal toxicity and neutropenia in patients. However, the Johns Hopkins study data do suggest that the drug helped reduce the incidence of cytomegalovirus (CMV) disease. Volunteers in the study are being asked to return to study sites for a final eye exam so that researchers may learn more about the drug's possible effects on CMV.
Keywords: Acyclovir/ANALOGS & DERIVATIVES/ADVERSE EFFECTS/*THERAPEUTIC USE Antiviral Agents/*THERAPEUTIC USE Cytomegalovirus Infections/*DRUG THERAPY Dose-Response Relationship, Drug Human Valine/ANALOGS & DERIVATIVES/ADVERSE EFFECTS/*THERAPEUTIC USE NEWSLETTER ARTICLE RANDOMIZED CONTROLLED TRIAL CLINICAL TRIALKWDacyclovir/analogs&derivatives/adverseeffects/KWDtherapeuticuseantiviralagents/KWDtherapeuticusecytomegalovirusinfections/KWDdrugtherapydose-responserelationship,drughumanvaline/analogs&derivatives/adverseeffects/KWDtherapeuticusenewsletterarticlerandomizedcontrolledtrialclinicaltrial
951230
M95C3202

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